[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Essilor International\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":361},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,14,0,[8,42,71,95,120,145,168,190,211,233,257,285,310,334],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100628535","evaluation-of-the-effectiveness-of-a-new-generation-of-myopia-control-lens-on-the-progression-of-myopia-in-children-aged-6-to-14-years-100628535",false,"NCT07462897","Evaluation of the Effectiveness of a New Generation of Myopia Control Lens on the Progression of Myopia in Children Aged 6 to 14 Years","Evaluation of the Effectiveness of a New Generation of Myopia Control Lens, Producing a Higher Myopic Control Signal Than That Produced by a Previous Generation Lens, on the Progression of Myopia in Children Aged 6 to 14 Years","VERCORS","Inclusion Criteria:\n\n* Refractive error in spherical equivalent (SE) ≤ -0.5 D and ≥ -4.5 D on each eye (autorefraction under cycloplegia)\n* Astigmatism ≤ 2.00 D for each eye\n* Anisometropia (difference in SE between the 2 eyes) ≤ 1.00 D\n* Corrected maximum distance visual acuity in each eye≥ 8\u002F10 (equivalent to +0.1 LogMAR)\n* Written consent of the 2 holders of parental authority (or only one in the case of exclusive parental authority) and agreement of the participant\n\nExclusion Criteria:\n\n* Past or current use of any type of myopic control solution (braking lenses, atropine, orthokeratology, multifocal contact lenses, etc\n* Strabismus (in the test of masking near or far with the best correction)\n* Amblyopia\n* Any ocular or systemic condition known to affect refractive status (e.g., keratoconus, diabetes, Down syndrome, etc.)\n* Presence of trauma in at least one eye - Presence of inflammatory pathologies in at least one eye\n* History of intraocular surgery (cataracts, filtering surgery, intravitreal surgery) in at least one eye\n* Past or current use of growth hormones\n* Use of ocular or systemic drugs that, in the opinion of the investigator, may significantly affect pupil size, accommodation, or refractive status.\n* Wearing contact lenses\n* Allergy or intolerance to cycloplegic eye drops (cyclopentolate 0.5%)\n* Known allergy or intolerance to eyeglass frame materials\n* Children with specific visual disorders requiring personalized treatments other than conventional corrective lenses.\n* Intolerance to conventional optical corrections\n* Lack of cooperation in wearing corrective lenses","ALL","6 Years","14 Years",{"count":21,"type":22},76,"ESTIMATED","INTERVENTIONAL",[25],"NA","The goal of this clinical investigation is to learn how much a new generation of myopia control lens (MCL1 - Myopia Control Lens 1) is helpful in reducing myopia progression in children from 6 to 14 yo. The main questions it aims to answer is: How much this new generation of lens, called MCL1, slows down the growth of the eye? Researchers will compare MCL1 to a former generation of myopia control lens (i.e. MCL2) but with better vision quality.\n\nParticipants will:\n\n* Wear MCL1 on right eye and MCL2 on left eye for 6 months and MCL2 on rigth eye and MCL1 on left eye for the next 6 months;\n* Visit the hospital at 6 and 12 months for tests;\n* Answer weekly questionnaires on compliance wearing glasses, quality of vision and out-of-school activities.",[28],"Myopia Progression","RECRUITING","2026-04-20",{"date":32,"type":33},"2026-04-23","ACTUAL",{"date":35,"type":33},"2026-03-18",{"date":37,"type":22},"2028-05",{"name":39,"class":40},"Essilor International","INDUSTRY",1,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":4,"eligibilityCriteria":48,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":49,"enrollmentInfo":50,"targetDuration":4,"studyType":23,"phases":52,"briefSummary":53,"conditions":54,"keywords":57,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":41},"100633935","targeted-lens-intervention-for-myopic-anisometropia-in-children-100633935","NCT07533149","Targeted Lens Intervention for Myopic Anisometropia in Children","Clinical Investigation of Targeted Lens Intervention in the Management of Myopic Anisometropia in Children","Inclusion Criteria:\n\n1. Voluntary\n2. Informed consent of parent\u002Fguardian and assent of participant\n3. Age equal to or greater than 6 years old and less than 13 years at the time of signing informed consent and assent\n4. SER equal or less than -0.50 D and equal or greater than .5.00 D with astigmatism not more than 2.50 D\n5. Difference in SER (anisometropia) between two eyes .1.00 D\n6. Best corrected visual acuity (BCVA) better than or equal to +0.20 LogMAR in each eye\n7. Agree to wear study spectacles for .12 hours\u002Fday and 7 days\u002Fweek\n8. Willingness and ability to participate in investigation for 12 months and attend scheduled visits punctually\n9. Agree for no concurrent involvement in other myopia control treatment\n\nExclusion Criteria:\n\n1. History or presence of an ocular disease affecting refractive status\n2. History or presence of strabismus\n3. Presence of amblyopia\n4. Current or previous use of atropine and\u002For orthokeratology\n5. Known allergy to cycloplegic agents\n6. Contraindication to cycloplegic agents\n7. Cognitive or psychological vulnerability","13 Years",{"count":51,"type":22},20,[25],"The goal of this clinical trial is to learn if our research spectacles will lower the difference in prescription (spectacles degree) between the eyes in children between 6 to 13 years old with anisometropic myopia. Anisometropic myopia is when the difference in myopia prescription between the two eyes are more than 1 diopter. The main question it aims to answer is:\n\n* How the eye responds to the research spectacles over time by measuring:\n\n  1. Change in axial length: the physical length of the eye from front to back.\n  2. Change in cycloplegic spherical equivalent refraction: an accurate measurement of the eye's prescription taken while the focusing muscles are temporarily relaxed with eye drops.\n\n     Participants will:\n* Wear the study spectacles\n* Visit Essilor R\\&D Centre and an eye clinic for follow-up sessions",[55,56],"Anisometropia","Myopia",[58,59,60,61],"myopia control","anisometropia","axial length","spherical equivalent refraction","NOT_YET_RECRUITING","2026-04-09",{"date":65,"type":33},"2026-04-16",{"date":67,"type":22},"2026-04",{"date":69,"type":22},"2027-07",{"name":39,"class":40},{"id":72,"slug":73,"hasResults":11,"nctId":74,"briefTitle":75,"officialTitle":76,"acronym":77,"eligibilityCriteria":78,"healthyVolunteers":79,"sex":17,"minAge":80,"maxAge":81,"enrollmentInfo":82,"targetDuration":4,"studyType":23,"phases":84,"briefSummary":85,"conditions":86,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":91,"completionDateStruct":92,"leadSponsor":94,"locationsCount":41},"100631323","a-study-on-body-posture-and-eye-movements-during-screen-usage-on-adults-aged-18-to-65-wearing-various-types-of-eyeglasses-100631323","NCT07499180","A Study on Body Posture and Eye Movements During Screen Usage on Adults Aged 18 to 65 Wearing Various Types of Eyeglasses","Etude Des Comportements Posturaux et Oculomoteurs Durant l'Utilisation d'Outils Digitaux","POEM","Inclusion Criteria:\n\n* Distance refractive error (equivalent sphere) between -3D and +3D\n* Astigmatism inferior or equal to 1D\n* Anisometropia inferior or equal to 1.5D\n* Addition (for presbyopes) between 0.75D and 2.75D\n* Minimum corrected visual acuity : 8\u002F10\n* Stable binocular vision\n\nExclusion Criteria:\n\n* Employee of Essilor, Luxottica, GrandVision and their subsidiaries\n* Aphakia, pseudophakia or ocular surgery\n* Reported systemic pathology that affects vision\n* Medical treatment or taking medications that affect vision\n* Severe ocular pathology declared, involving a loss of visual field as in glaucoma, a loss of acuity\n* Reported neurological deficit, including a history of seizure or sensorimotor coordination disorders, vestibular or cerebellar pathology\n* Binocular vision problems such as amblyopia, strabismus, or double vision\n* Vertebral or cervical troubles\n* Difficulty to move, vertigo, ocular migraine",true,"18 Years","65 Years",{"count":83,"type":22},69,[25],"The goal of this clinical study is to evaluate how adults aged 18 to 65 move their bodies and eyes when they use screens, with various eyeglasses. The main questions it aims to answer are :\n\n* How the behaviour between young and presbyopes is different while performing visual tasks on digital devices ?\n* How the behaviour while performing visual tasks changes according to different types of eyeglasses ? Participants will be asked to take part in an eye exam and do simple visual tasks on digital devices.",[87],"Healthy Adults","2026-04-07",{"date":90,"type":33},"2026-04-13",{"date":88,"type":33},{"date":93,"type":22},"2026-10",{"name":39,"class":40},{"id":96,"slug":97,"hasResults":11,"nctId":98,"briefTitle":99,"officialTitle":100,"acronym":101,"eligibilityCriteria":102,"healthyVolunteers":79,"sex":17,"minAge":103,"maxAge":104,"enrollmentInfo":105,"targetDuration":4,"studyType":23,"phases":107,"briefSummary":108,"conditions":109,"keywords":111,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":113,"lastUpdatePostDateStruct":114,"startDateStruct":116,"completionDateStruct":117,"leadSponsor":119,"locationsCount":41},"100626784","visual-and-postural-behavior-in-myopic-and-non-myopic-teenagers-100626784","NCT07440134","Visual and Postural Behavior in Myopic and Non-Myopic Teenagers","Comportement Visuo-postural Des Adolescents Myopes et Non Myopes (CALYPSO)","CALYPSO","Inclusion Criteria:\n\n* Volunteer adolescent, fluent in French, able to follow protocol and read and write\n* Aged between 12 and 17 years and 6 months\n* Adolescent with no history, according to the participant and\u002For their legal representatives, of any pathology, deficit, or disorder that could interfere with visual or cognitive functions.\n* If the subject wears glasses, they must have an ophthalmic prescription dated within the last year, certifying that a consultation was carried out during the previous year\n* If the subject wears Essilor® Stellest® 1.0 lenses, they must have worn them for at least two (2) consecutive months prior to inclusion in the study.\n* If the subject is nearsighted: -6.5D ≤ equivalent sphere ≤ -0.5D with usual correction\n* If the subject is not nearsighted: -0.5 \\\u003C equivalent sphere ≤ +2.5\n\nExclusion Criteria:\n\n* Age ≤ 12 years\n* Age \\> 17 years and 6 months\n* Pregnant or breastfeeding women (Article L1121-5)\n* Persons (legal representatives or subjects) deprived of their liberty by a judicial or administrative decision and persons hospitalized without consent pursuant to Articles L. 3212-1 and L. 3213-1 who are not covered by the provisions of Article L. 1121-8 and persons admitted to a health or social care facility for purposes other than research\n* Participants who are currently excluded from another study\n* All categories of persons who are particularly protected under French law are excluded from this research (Articles L1121-5 to L1121-9 of the Public Health Code)\n* Declared neurological deficit, in particular a history of epileptic pathology or sensorimotor coordination disorders, vestibular or cerebellar pathology (e.g., balance disorders)\n* Severe declared eye disease involving loss of visual field, such as glaucoma, involving loss of acuity and severe discomfort in low-light or overly bright environments, such as retinitis pigmentosa, or declared and treated dry eye syndrome.\n* Gougerot-Sjögren syndrome or declared dry eye syndrome\n* Declared aphakia or pseudophakia (intraocular implant)\n* Declared systemic pathology, medical treatment, or medication with an effect on vision\n* People with declared muscle paralysis\n* Binocular vision problems such as amblyopia, strabismus, or nystagmus\n* Children of employees or employees of Essilor International, Luxottica, GrandVision, and their subsidiaries\n* Individuals who have undergone previous refractive surgery, have a history of strabismus surgery, or have a history of any type of eye surgery","12 Years","17 Years",{"count":106,"type":22},100,[25],"The goal of this observational study is to learn whether different types of eyeglasses prescription and different types of lenses change how close teenagers hold objects when looking at them up close. The study includes adolescents who are non-myopic and adolescents who are myopic and wear either single-vision lenses or lenses slowing down myopia progression.\n\nThe main questions it aims to answer are:\n\nDo teenagers in these three groups use different average working distances (eye-to-object distance) during everyday tasks?\n\nDoes wearing Essilor® Stellest® lenses change working distance compared with wearing single-vision lenses?\n\nResearchers will compare the three groups to see if their working distances differ.\n\nParticipants will:\n\nComplete an initial optometric eye examination.\n\nCome for a second visit where they perform everyday activities while wearing a motion-capture system that measures how they move and how far they hold objects.",[110,56],"Teenagers",[56,112],"Ophthalmological measurements","2026-04-02",{"date":115,"type":33},"2026-04-03",{"date":115,"type":22},{"date":118,"type":22},"2027-05",{"name":39,"class":40},{"id":121,"slug":122,"hasResults":11,"nctId":123,"briefTitle":124,"officialTitle":125,"acronym":126,"eligibilityCriteria":127,"healthyVolunteers":79,"sex":17,"minAge":18,"maxAge":103,"enrollmentInfo":128,"targetDuration":4,"studyType":23,"phases":129,"briefSummary":130,"conditions":131,"keywords":133,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":137,"lastUpdatePostDateStruct":138,"startDateStruct":140,"completionDateStruct":142,"leadSponsor":144,"locationsCount":41},"100618709","eye-imaging-for-the-study-of-childhood-myopia-100618709","NCT07335146","Eye Imaging for the Study of Childhood Myopia","Modélisation de l'œil Myope Infantile Par IRM et OCT","SELENA","Inclusion Criteria:\n\n* Spherical equivalent under cycloplegia greater -6.5 D and less than 2 D\n* Beneficiary of social security\n* Written consent from both holders of parental authority (or from one in case of exclusive parental authority)\n\nExclusion Criteria:\n\n* Declared neurological deficit, including history of epileptic pathology or sensory-motor coordination disorders, vestibular or cerebellar pathology (for example, balance disorders)\n* Current or progressive pathology of the eyes or their appendages that may affect vision, other than myopia (examples: glaucoma, retinitis pigmentosa…)\n* Declared aphakia or pseudophakia (intraocular implant)\n* Ocular motility problem such as strabismus or nystagmus\n* Contraindication to MRI (claustrophobia, implanted devices such as pacemaker, etc.)",{"count":106,"type":22},[25],"Myopia (nearsightedness) is increasing worldwide and is becoming a serious public health problem. Studies estimate that by 2050, if no action is taken, almost half of the world's population will be myopic. About 10% of people could develop severe myopia, which increases the risk of serious eye problems such as retinal detachment, damage to the macula, or glaucoma.\n\nChildren are particularly affected because myopia often worsens as they grow. Several treatments are now available to slow the progression of myopia in children, but these treatments are not equally effective for everyone. Some children respond better than others, and the reasons for these differences are not yet well understood. One possible explanation is that differences in eye anatomy may influence the effectiveness of a treatment. This suggests that myopia treatments may need to be tailored to each child. By studying the anatomy of the eye, researchers could improve and personalize myopia control strategies.\n\nThe study entitled \"Eye imaging for the study of childhood myopia\" aims to better understand the structure of children's eyes. The study will collect clinical data, including images of the eye taken with MRI and measurements of the eye obtained using standard eye examination devices. The data will then be analyzed using image-processing and statistical methods to allow a detailed study of children's eye anatomy.",[132],"Hyperopia and Myopia",[134,135,136],"myopia","eye anatomy","ophthalmological measurements","2026-03-27",{"date":139,"type":33},"2026-03-30",{"date":141,"type":33},"2026-02-18",{"date":143,"type":22},"2027-12",{"name":39,"class":40},{"id":146,"slug":147,"hasResults":11,"nctId":148,"briefTitle":149,"officialTitle":150,"acronym":151,"eligibilityCriteria":152,"healthyVolunteers":79,"sex":17,"minAge":80,"maxAge":81,"enrollmentInfo":153,"targetDuration":4,"studyType":23,"phases":155,"briefSummary":156,"conditions":157,"keywords":159,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":161,"lastUpdatePostDateStruct":162,"startDateStruct":163,"completionDateStruct":165,"leadSponsor":167,"locationsCount":41},"100631324","study-of-blinking-as-a-function-of-tear-film-quality-100631324","NCT07499193","Study of Blinking as a Function of Tear Film Quality","Etude Des Clignements en Fonction de la Qualité du Film Lacrymal","WINK","Inclusion Criteria:\n\n* Volunteer, fluent in French, willing to follow the protocol, able to read and understand the information sheet and provide free and informed consent\n* Covered by a social security\n* Aged between 18 and 65 years inclusive\n* Binocular near visual acuity ≤ 0.3 LogMAR (≥ 5\u002F10) (corrective glasses accepted)\n\nExclusion Criteria:\n\n* Employees of Essilor International, Luxottica, or GrandVision and their subsidiaries\n* Pregnant or breastfeeding women (Article L1121-5)\n* Individuals deprived of liberty by judicial or administrative decision, or hospitalized without consent under Articles L.3212-1 and L.3213-1, who do not fall under Article L.1121-8, and individuals admitted to a health or social care facility for purposes other than research\n* Adults unable or incapable of giving informed consent (Article L1121-8)\n* Participants currently in an exclusion period from another study\n* Participants deemed unfit to participate by the investigator for any reason that may affect subject safety or study integrity All categories of individuals particularly protected under French law are excluded from this research (Articles L1121-5 to L1121-9 of the French Public Health Code).\n* Use of eye drops or ophthalmic solutions within the last 2 hours\n* Wearing contact lenses within the last 48 hours\n* Reported history of severe ocular pathology such as glaucoma, retinitis pigmentosa, diabetic retinopathy, macular involvement, resulting in visual field loss or acuity loss (especially aphakia), except for dry eye (which is not an exclusion criterion)\n* Reported history of eye surgery or trauma to the eye or its adnexa excepted refractive surgery and cataract surgery\n* Reported history of eyelid abnormalities (ptosis)\n* Reported history of neurological deficits, including epilepsy or sensory-motor coordination disorders, vestibular or cerebellar pathology (e.g., balance disorders, nystagmus, Parkinson's disease)\n* Reported history of musculoskeletal disorders preventing maintenance of a fixed head position",{"count":154,"type":22},60,[25],"The goal of this study is to better understand how eye blinking behavior is linked to the stability of the tear film, in adults aged 18 to 65 years, with or without symptoms of dry eye.\n\nThe main questions are:\n\n* Do the results of a New Blink Task reflect tear film stability ?\n* How are the blink related metrics in relation with each other? Researchers will compare two groups of participants-those without dry eye symptoms and those with dry eye symptoms-to see if blinking measures differ between them and whether these measures relate differently to tear film quality.\n\nParticipants will:\n\n* Answer a questionnaire about dry eye symptoms\n* Have their visual correction measured (if they wear glasses)\n* Undergo non-invasive assessments of tear film quality using an imaging device\n* Complete three types of blink tasks, each repeated three times, including measurements of blinking and of tear film stability",[158],"Dry Eye",[160],"dry eye","2026-03-23",{"date":139,"type":33},{"date":164,"type":22},"2026-03",{"date":166,"type":22},"2026-06",{"name":39,"class":40},{"id":169,"slug":170,"hasResults":11,"nctId":171,"briefTitle":172,"officialTitle":173,"acronym":174,"eligibilityCriteria":175,"healthyVolunteers":79,"sex":17,"minAge":80,"maxAge":176,"enrollmentInfo":177,"targetDuration":4,"studyType":23,"phases":178,"briefSummary":179,"conditions":180,"keywords":4,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":182,"lastUpdatePostDateStruct":183,"startDateStruct":185,"completionDateStruct":187,"leadSponsor":189,"locationsCount":41},"100623419","understanding-how-young-adults-perceive-blurred-image-quality-and-creating-a-model-predicting-their-quality-ratings-100623419","NCT07396389","Understanding How Young Adults Perceive Blurred Image Quality and Creating a Model Predicting Their Quality Ratings","Modèle de Performance Subjective Généralisé","GESUVIPE","Inclusion Criteria:\n\n* Distance refractive error (equivalent sphere) between -7 D and +5 D\n* Astigmatism below 4D\n* Minimum corrected visual acuity: 10\u002F10\n\nExclusion Criteria:\n\n* Aphakic or pseudophakic eye surgery\n* Reported systemic pathology that affects vision\n* Medical treatment or taking medications that affect vision\n* Severe ocular pathology declared, involving a loss of visual field as in glaucoma, a loss of acuity\n* Reported neurological deficit, including a history of seizure or sensorimotor coordination disorders, vestibular or cerebellar pathology\n* Binocular vision problems such as amblyopia, strabismus, or double vision","30 Years",{"count":51,"type":22},[25],"This clinical study wants to understand how blurred images look to young adults.\n\nThe main question is: How do different kinds of images and different kinds of blur change the way people think those images look? Participants will get an eye exam, then look at several blurred images and rate how good or bad each one looks on a quality scale from 1 (very bad) to 10 (very good).",[181],"Healthy Young Adults","2026-02-09",{"date":184,"type":33},"2026-02-11",{"date":186,"type":22},"2026-02",{"date":188,"type":22},"2026-05",{"name":39,"class":40},{"id":191,"slug":192,"hasResults":11,"nctId":193,"briefTitle":194,"officialTitle":195,"acronym":4,"eligibilityCriteria":196,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":103,"enrollmentInfo":197,"targetDuration":4,"studyType":23,"phases":199,"briefSummary":200,"conditions":201,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":203,"lastUpdatePostDateStruct":204,"startDateStruct":206,"completionDateStruct":208,"leadSponsor":210,"locationsCount":41},"100620232","an-evaluation-of-myopia-control-lenses-on-wearing-experience-in-myopic-children-100620232","NCT07354945","An Evaluation of Myopia Control Lenses on Wearing Experience in Myopic Children","An Evaluation of Visual Comfort, Adaptation and Overall Satisfaction in Myopic Children Using A.M.L. Series of Lenses","Inclusion Criteria:\n\n* Volunteer participant\n* Informed consent of parent\u002Fguardian and assent of participant\n* Age equal to or greater than 6 years and not older than 12 years at the time of signing informed consent and assent\n* Spherical equivalent refraction (SER) by cycloplegic autorefraction equal or less than -0.50 D and equal or greater than -4.75D with astigmatism not more than 2.00 D on both eye\n* Difference in SER (anisometropia) between two eyes should not exceed 1.50 D\n* Best corrected visual acuity (BCVA) better than or equal to +0.10 LogMAR in each eye\n* Be in good general health, based on the participant and the parent's\u002Fguardian's knowledge\n* Willingness and ability to participate in study and comply with all scheduled visits\n\nExclusion Criteria:\n\n* History of Atropine, Orthokeratology, or Red Light treatment\n* Strabismus by cover test at near or distance wearing correction\n* Amblyopia\n* Any ocular or systemic condition known to affect refractive status (e.g. keratoconus, diabetes, Downs syndrome, or other developmental disorders, etc.)\n* Current use of ocular or systemic medications which, in the investigator's opinion, may significantly affect pupil size, accommodation or refractive state\n* History of ocular injury or surgery\n* Participation in any clinical study within 30 days of the Baseline visit\n* Study participants deemed inappropriate for the study by the investigator\n* The inherent ocular\u002Fsystemic discomfort (dry eyes, visual fatigue, headaches, etc.) that may affect the evaluation of the study lens wearing experience, from the investigator's perspective",{"count":198,"type":22},40,[25],"The goal of this research study is to understand the wearing experience of A.M.L. series of lenses in myopic children. The main questions it aims to answer are:\n\n* How quickly and effectively children adapt to the A.M.L. series of lenses?\n* The proportion of children who adapted to the A.M.L. series of lenses within 4 to 6 days?\n\n  40 myopic children aged 6 to 12 years will be recruited as participants, and all of them will be wearing A.M.L. series of lenses.\n\nParticipants will:\n\n* Wear A.M.L. series of lenses for a period of 2 weeks\n* Visit at day 4-6, week 1 and week 2.",[56,202],"Refractive Error","2026-01-22",{"date":205,"type":33},"2026-01-23",{"date":207,"type":33},"2026-01-02",{"date":209,"type":22},"2026-04-27",{"name":39,"class":40},{"id":212,"slug":213,"hasResults":11,"nctId":214,"briefTitle":215,"officialTitle":216,"acronym":217,"eligibilityCriteria":218,"healthyVolunteers":79,"sex":17,"minAge":80,"maxAge":219,"enrollmentInfo":220,"targetDuration":4,"studyType":23,"phases":222,"briefSummary":223,"conditions":224,"keywords":4,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":225,"lastUpdatePostDateStruct":226,"startDateStruct":228,"completionDateStruct":230,"leadSponsor":232,"locationsCount":41},"100615838","development-of-a-new-device-and-method-to-assess-the-degree-of-myopia-andor-astigmatism-in-myopic-people-100615838","NCT07297810","Development of a New Device and Method to Assess the Degree of Myopia and\u002For Astigmatism in Myopic People","Development of a New Device and Method for Determining Refractive Errors in a Myopic Population","MDSW_DiVA2Rx","Inclusion Criteria:\n\n* Volunteers, fluent in French, willing to follow the protocol, able to read and understand the information form and give free and informed consent\n* Aged between 18 and 39 years at the time of study inclusion\n* Wear corrective glasses\n* With an ophthalmologist's prescription for corrective eyewear less than 3 years old\n* Spherical error of each meridian within the range of \\[-5.00 ; -0.50 D\\]\n* Cylindrical defect included in interval \\[-4.50 ; 0.00 D\\]\n* Corrected monocular visual acuity ≤ 0.0 logMAR for distance vision (≥10\u002F10)\n* French Social Security beneficiary\n\nExclusion Criteria:\n\nGeneral criteria for non-inclusion:\n\n* Essilor International employee\n* Pregnant, or breast-feeding women (Article L1121-5)\n* Persons deprived of their liberty by a judicial or administrative decision and persons hospitalized without consent under Articles L. 3212-1 and L. 3213-1 who are not covered by the provisions of Article L. 1121-8 and persons admitted to a health or social establishment for purposes other than research\n* Adults incapable or unable to express consent (Article L1121-8)\n* Participant included in another ongoing study or in a period of exclusion\n* All categories of persons particularly protected under French law are excluded from this research (Articles L1121-5 to L1121-9 of the French Public Health Code)\n* Amblyopia, strabismus, nystagmus\n* Wearing progressive lenses\n\nThe following elements are considered based on the participant's declaration :\n\n* Declared cataract, Aphakia (without lens) or pseudophakia (with intraocular implant)\n* Ocular surgery (iridectomy, refractive surgery, corneal transplant)\n* Ocular trauma (corneal deformation, contusion, chemical burn, foreign body intrusion, perforation, orbital fracture, enucleation)\n* Severe ocular pathology, involving loss of visual field as in glaucoma or retinitis pigmentosa, involving loss of acuity and severe discomfort in dimly or brightly lit environments as in Age related macular degeneration (AMD) or overt and treated dry eye.\n* Systemic pathology affecting vision (diabetes, uncontrolled blood pressure, myasthenia gravis, etc.).\n* Medication that may affect vision or interfere with study measures (antidepressants, medication with atropine-like effects).\n* Declared neurological deficits, in particular a history of epileptic pathology or sensory-motor coordination disorders, vestibular or cerebellar pathology (e.g. balance disorders).","39 Years",{"count":221,"type":22},30,[25],"The purpose of this clinical investigation is to check whether the new device can correctly measure a person's degree of myopia and astigmatism.\n\nTo evaluate and improve the device's performance, the results (optical correction values and the associated visual acuity) obtained with the investigational device will be compared with the results obtained using standard instruments commonly used by eye care professionals.",[56],"2025-12-09",{"date":227,"type":33},"2025-12-22",{"date":229,"type":22},"2025-12",{"date":231,"type":22},"2027-09",{"name":39,"class":40},{"id":234,"slug":235,"hasResults":11,"nctId":236,"briefTitle":237,"officialTitle":237,"acronym":4,"eligibilityCriteria":238,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":239,"enrollmentInfo":240,"targetDuration":4,"studyType":23,"phases":242,"briefSummary":243,"conditions":244,"keywords":245,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":250,"lastUpdatePostDateStruct":251,"startDateStruct":253,"completionDateStruct":255,"leadSponsor":256,"locationsCount":41},"100581427","clinical-investigation-of-a-novel-spectacle-lens-on-slowing-down-juvenile-myopia-progression-100581427","NCT06850168","Clinical Investigation of a Novel Spectacle Lens on Slowing Down Juvenile Myopia Progression","Inclusion Criteria:\n\n* Children equal to or greater than 6 years old and less than 11 years at the time of signing informed consent.\n* Corrected spherical equivalent refraction (SER) between -0.75 D and -5.00 D with astigmatism not more than 2.50 D.\n* Difference in SER (Anisometropia) between two eyes should not exceed 1.00 D.\n* Best corrected visual acuity better than or equal to +0.10 log MAR (20\u002F25 or better with Snellen).\n* Be in good general health, based on his\u002Fher and parent's\u002Fguardian's knowledge.\n* Agree to wear spectacles for \\>12 hours\u002Fday and at least 6 days\u002Fweek.\n* Willingness and ability to participate in investigation for 2 years and attend scheduled visits.\n\nExclusion Criteria:\n\n* Any ocular or systemic pathologies known to affect refractive status (e.g. keratoconus, diabetes, Down's syndrome etc.)\n* Any binocular vision anomalies\n* Amblyopia\n* Use of prior myopia control treatment like specialized myopia control spectacles and contact lenses at least in the previous one month.\n* Current use of ocular or systemic medications which, in the investigator's opinion, may significantly affect pupil size, accommodation or refractive state.\n* Participation in any clinical investigation within 30 days of the baseline visit.","11 Years",{"count":241,"type":22},35,[25],"The goal of this exploratory clinical trial is to evaluate the efficacy and safety of a test spectacle lens (standard single vision lens (SVL) during first year, and standard myopia control lens (MCL) in second year), designed with passive red-light emission, for the control of myopia progression in myopic children age 6 to 11 years old, both male and female, with no systemic or ocular anomalies. The main question it aims to answer is:\n\nDoes the test spectacle lens designed with passive red-light emission provide significant myopia control effect to children?\n\nResearchers will compare the standard SVL designed with passive red-light emission to SVL (first year) and MCL designed with passive red-light emission to MCL (second year) to see if the test spectacle lens work to slow down myopia progression.\n\nParticipants will:\n\n* Wear the study spectacles\n* Visit Essilor R\\&D Centre for follow-up sessions",[56],[246,247,248,249],"Refractive error","Eye disease","Axial length","Myopia control","2025-08-04",{"date":252,"type":33},"2025-08-07",{"date":254,"type":33},"2025-06-26",{"date":143,"type":22},{"name":39,"class":40},{"id":258,"slug":259,"hasResults":11,"nctId":260,"briefTitle":261,"officialTitle":261,"acronym":4,"eligibilityCriteria":262,"healthyVolunteers":79,"sex":17,"minAge":18,"maxAge":103,"enrollmentInfo":263,"targetDuration":4,"studyType":23,"phases":265,"briefSummary":266,"conditions":267,"keywords":273,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":277,"lastUpdatePostDateStruct":278,"startDateStruct":280,"completionDateStruct":282,"leadSponsor":284,"locationsCount":41},"100596484","algorithm-assisted-subjective-refraction-program-dedicated-to-children-100596484","NCT07046065","Algorithm-assisted Subjective Refraction Program Dedicated to Children","Inclusion Criteria:\n\n1. Age between 6 and 12 years\n2. Subject able to recognize and name the letters of the Latin alphabet\n3. Pupillary distance (PD) not less than 49mm\n4. Distance refractive error for spherical equivalence (SE) within the range of \\[-6.00 to +6.00 D\\] maximum of the two absolute values RE and LE; Cyl ≤ 3.00 D\n5. Monocular Visual acuity ≥ +0.30 LogMAR (0.5 Decimal VA) in each eye at distance\n6. Visual acuity difference \\\u003C 0.20 logMAR between right and left eyes at distance\n\nExclusion Criteria:\n\n1. Vulnerability of the subject\n2. Amblyopia\n3. Strabismus\n4. Any current or evolving pathology manifested in the eye or the appendages which might have an influence on vision, or interfere with refractive state\n5. Any previous ocular surgery, which might have an influence on vision or interfere with study assessments (e.g. iridectomy, refractive surgery…)\n6. Any ocular or systemic condition known to affect refractive status (e.g., keratoconus, diabetes, Down's syndrome, etc.)\n7. Any neurological or speech disorders that might interfere with the ability to understand and answer questions or communicate with the ECP\n8. Any untreated and\u002For uncontrolled systemic condition which might have an influence on vision or interfere with study assessments\n9. Current use of ocular or systemic medications, which, in the Investigator's opinion, may significantly affect pupil size, accommodation or refractive state\n10. History of myopia control intervention that may affect refractive assessment (e.g., atropine, orthokeratology, rigid gas permeable lenses (RGP) etc.) except myopia control spectacles\n11. Contraindications of cycloplegia (e.g. high Intra-ocular pressure - more than 22mmHg in either eye, narrow anterior angle, history of allergy to cycloplegic agents or seizures, etc)\n12. Aphakic or pseudoaphakic (intraocular lens),\n13. Prismatic prescription in either Right or Left eye (horizontal or vertical). -",{"count":264,"type":22},166,[25],"Current refraction assessment in children is dependent on the Eye Care Specialist and lacks standardization. Essilor has developed new algorithm assisted subjective refraction software dedicated to children of 6-12 years old and suitable for use with Vision-S™ and Vision-R™ phoropters, in addition to existing software.\n\nTwo different versions of the software have been developed: the first incorporating only the steps needed to perform an entire subjective refraction process (vA), and the second, identical to the first but incorporating additional steps useful for managing the child's attention and cooperation (vB).\n\nThe software performance in terms of subjective refraction results will be compared to a conventional subjective refraction method performed with the Vision-R™700 phoropter in manual mode.",[268,269,132,270,271,272],"Refractive Assessment","Refractive Disorders","Astigmatism","Refractive Error Correction","Children",[274,275,276],"cycloplegic refraction","non-cycloplegic refraction","subjective refraction","2025-06-23",{"date":279,"type":33},"2025-07-01",{"date":281,"type":33},"2025-05-23",{"date":283,"type":22},"2025-12-31",{"name":39,"class":40},{"id":286,"slug":287,"hasResults":11,"nctId":288,"briefTitle":289,"officialTitle":290,"acronym":4,"eligibilityCriteria":291,"healthyVolunteers":79,"sex":17,"minAge":292,"maxAge":293,"enrollmentInfo":294,"targetDuration":4,"studyType":23,"phases":296,"briefSummary":297,"conditions":298,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":302,"lastUpdatePostDateStruct":303,"startDateStruct":305,"completionDateStruct":307,"leadSponsor":308,"locationsCount":309},"100583905","the-objective-of-this-study-is-to-evaluate-the-perfomance-of-a-photorefraction-device-for-screening-ametropia-in-children-eligible-participants-will-undergo-multiple-refractive-error-measurements-visual-acuity-and-strabismus-assessments-during-a-single-evaluation-visit-100583905","NCT06882408","The Objective of This Study is to Evaluate the Perfomance of a Photorefraction Device for Screening Ametropia in Children. Eligible Participants Will Undergo Multiple Refractive Error Measurements, Visual Acuity and Strabismus Assessments During a Single Evaluation Visit.","Evaluation of the Photorefraction Screener Snapsight in Comparison With Cycloplegia Table-top Autorefractor in Ametropia in Pediatric Population Between 3 and 8yo, Multicenter French Study.","Inclusion Criteria:\n\n* Aged between 3-8 years when included in the study\n* All skin phototypes (I to VI according to the Fitzpatrick classification)\n* Wearing glasses or not\n* Capacity to give valid consent\n* Capacity to follow the protocol to obtain reliable measure\n* Under French medical insurance\n\nExclusion Criteria:\n\n* Under myopia control solution that may have an impact on refractive error (such as: atropine, orthokeratology,..)\n* Wearing contact lenses\n* Ocular or systemic pathology that may have an impact on vision or may interfere with the study measures (except strabismus)\n* Under medication that may have an impact on vision or may interfere with study measurements\n* Known contraindication to the active substance or to one of the excipients of eye drops (Mydriaticum 0.5%, Skiacol 0.5%)\n* Known risk of angle-closure glaucoma\n* Participation to another study that may have an impact on vision or may interfere with the study measures","3 Years","8 Years",{"count":295,"type":22},315,[25],"The goal of this clinical trial is to evaluate the performance of a photorefraction screener in terms of sensibility, sensitivity and accuracy on children aged 3 to 8 y.o. The main objectives of the study are:\n\n* Evaluate the performances of the device in comparison with the gold standard, i.e. a tabletop refractometer.\n* Assess the agreement of the measures obtained with the device with those obtained with the gold standard.",[299,300,301],"Ametropia","Myopia; Refractive Error","Myopia; Astigmatism","2025-04-28",{"date":304,"type":33},"2025-04-29",{"date":306,"type":22},"2025-04",{"date":229,"type":22},{"name":39,"class":40},2,{"id":311,"slug":312,"hasResults":11,"nctId":313,"briefTitle":314,"officialTitle":315,"acronym":316,"eligibilityCriteria":317,"healthyVolunteers":79,"sex":17,"minAge":80,"maxAge":81,"enrollmentInfo":318,"targetDuration":4,"studyType":23,"phases":319,"briefSummary":320,"conditions":321,"keywords":323,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":326,"lastUpdatePostDateStruct":327,"startDateStruct":329,"completionDateStruct":331,"leadSponsor":333,"locationsCount":41},"100570033","study-on-the-effect-of-filters-on-discomfort-glare-on-healthy-adults-100570033","NCT06701981","Study on the Effect of Filters on Discomfort Glare on Healthy Adults","Etude De L'Effet De Filtres Sur L'Eblouissement D'Inconfort","PREVIS","Inclusion Criteria:\n\n* A willing person, fluent in French, inclined to follow protocol, capable of reading and understanding the information form, and able to give their free and informed consent.\n* Beneficiary of the French Social Security system\n* Aged 18 to 65 years\n* No or moderate ocular correction (Spherical prescription for distance vision: in the range \\[-8.00 to +6.00 D\\]\\* (negative cylinder) for each eye; Cylindrical prescription for distance vision: in the range \\[0 to -4.00 D\\] for each eye; Anisometropia ≤ 2.00 D on the equivalent sphere)\n* Correct vision with prescription glasses (Corrected visual acuity +0.10 logMAR or better (distance vision \u002F high contrast \u002F photopic luminance)\n* Regular user of sunglasses at least in bright light conditions\n\nExclusion Criteria:\n\n* Age \\\u003C 18 years (i.e., no minors in accordance with Article L1121-7 of the Public Health Code of \"Code de Santé Publique\")\n* Pregnant, parturient, or breastfeeding women (Article L1121-5 of the Public Health Code of \"Code de Santé Publique\")\n* Persons deprived of liberty by judicial or administrative decision and persons hospitalized without consent under Articles L. 3212-1 and L. 3213-1 who do not fall under the provisions of Article L. 1121-8, and persons admitted to a health or social institution for purposes other than research\n* Adults incapable or unable to express their consent (Article L1121-8 of the Public Health Code of \"Code de Santé Publique\")\n* Participant in the exclusion period of another biomedical research study\n* Participant who cannot be contacted in case of emergency\n* All categories of persons particularly protected under French law are excluded from this research (Articles L1121-5 to L1121-9 of the Public Health Code)\n* Employees at the Institut des Sciences de la Vision or EssilorLuxottica\n* Ocular pathology that may affect vision (e.g., glaucoma involving visual field loss, maculopathy involving visual acuity loss, or retinitis pigmentosa causing significant discomfort in poorly or overly lit environments)\n* Neurological deficit, including a history of epileptic pathology or regular or severe migraines\n* Ocular surgery affecting vision (e.g., refractive surgery, cataract surgery, or iridectomy)\n* Ocular or head trauma",{"count":154,"type":22},[25],"The goal of this clinical trial is to evaluate the glare protection provided by two filters compared to no filter. Using the Lumiz 100™ device (a headset with gradually increasing light), participants will measure their discomfort thresholds under three different conditions (one per filter). Each measurement will be repeated three times. The study requires a single visit of 2 hours for each participant. Glare protection will be quantified by comparing discomfort thresholds across the no-filter condition and the two studied filters.",[322],"Glare",[324,325],"glare","filter","2024-11-20",{"date":328,"type":33},"2024-11-22",{"date":330,"type":22},"2024-12-02",{"date":332,"type":22},"2025-03-31",{"name":39,"class":40},{"id":335,"slug":336,"hasResults":11,"nctId":337,"briefTitle":338,"officialTitle":339,"acronym":4,"eligibilityCriteria":340,"healthyVolunteers":79,"sex":17,"minAge":341,"maxAge":4,"enrollmentInfo":342,"targetDuration":4,"studyType":23,"phases":344,"briefSummary":345,"conditions":346,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":353,"lastUpdatePostDateStruct":354,"startDateStruct":356,"completionDateStruct":358,"leadSponsor":360,"locationsCount":41},"100559512","clinical-investigation-for-a-multifunction-ophthalmic-measurement-device-100559512","NCT06565091","Clinical Investigation for a Multifunction Ophthalmic Measurement Device","Development Clinical Investigation for a Multifunction Ophthalmic Measurement Device","Inclusion Criteria:\n\nAdults ≥ 18 years old and Healthy children\\* ≥ 4 years and \\\u003C18 of age.\n\nParticipants initially coming to the center for a routine consultation\n\nParticipants who are affiliated to a social security scheme or beneficiaries of such a scheme (L. 1121-8-1 of the Public Health Code of \"Code de Santé Publique\"),\n\nParticipants able to sit upright in front of the investigational device.\n\nInclusion Criteria\\* (for Healthy children):\n\nHealthy children ≥ 4 years and \\\u003C18 of age. The parents must have consented to their child's participation.\n\nChildren who are affiliated to parent's social security scheme or beneficiaries of such a scheme (L. 1121-8-1 of the Public Health Code of \"Code de Santé Publique\")\n\nChildren initially coming to the center for a routine consultation\n\nChildren able to sit upright in front of the instrument.\n\nExclusion Criteria:\n\nParticipants with implanted electronic medical device such as pacemaker, insulin pump, cochlear implant, electrostimulator or hearing aid,\n\nParticipants not able to sit upright in front of the instrument or subjects with forehead or chin injuries which prevent the head from being supported on the forehead \u002F chin rest.\n\nParticipants who are deprived of their liberty by judicial or administrative decision and persons hospitalized without their consent (Article L. 1121-6 of \"Code de Santé Publique\"),\n\nParticipants who are subject to a legal protection measure (curatorship, guardianship, safeguard of justice ...) or unable to express their consent (Article L1121-8 of \"Code de Santé Publique\"),\n\nParticipants who are not affiliated to a social security scheme or beneficiaries of such a scheme (L. 1121-8-1 of the Public Health Code of \"Code de Santé Publique\"),\n\nParticipants under exclusion period from another investigation,\n\nWomen who are pregnant or breastfeeding women; (Article L1121-5 of \"Code de Santé Publique\"). No additional risk had been identified for pregnant woman in participating in the investigation. Nevertheless, pregnancy induces ocular changes: in case of AE, the causality with the device or with pregnancy may be difficult to establish, justifying the non-inclusion of this population.\n\nParticipants with neurologic disorder, particularly epileptic or sensory motor troubles,\n\nParticipants with history of recent ocular surgeries (including refractive surgery less than 2 weeks),\n\nParticipants who are ESSILOR International\u002FESSILOR Luxottica employees,\n\nParticipants with monophthalmia,\n\nParticipants with obvious fixation disorder, strabismus, or nystagmus,\n\nFor tonometry measurements: subjects who have: Edematous\u002Fulcerated cornea, following keratoplasty or ocular surgery, following penetrating trauma, severe Keratoconus with risk of hydrops and in case of retinal detachment. Anterior and posterior chamber sulcus IOL, intrastromal rings or lens (type Kamra).\n\nParticipants with pupil \\\u003C 2 mm,\n\nParticipants who are with spherical equivalent refraction out of the range -20.00 to + 20.00 D (frontofocometer measurement),\n\nParticipants with an astigmatism greater than 8.00 D (\\\u003C8.00 D) (frontofocometer measurement),\n\nParticipants with corneal power out of the range \\[35-55D\\],\n\nParticipants with axial length out of the range \\[18-34 mm\\],\n\nParticipants with Intraocular pressure out of \\[7-50 mm Hg\\] range,\n\nParticipants to a previous phase of this clinical investigation.\n\nExclusion Criteria (for Healthy children):\n\nChildren with neurologic disorders, particularly epileptic or sensory motor troubles,\n\nChildren with history of recent ocular surgeries (including refractive surgery less than two weeks)\n\nChildren with monophthalmia,\n\nChildren with obvious fixation disorder, strabismus, or nystagmus,\n\nChildren with pupil \\\u003C 2 mm\n\nChildren with a spherical equivalent refraction out of the range \\[-20.00 to + 20.00 D\\] (frontofocometer measurement),\n\nChildren with an astigmatism higher than 8.00 D (\\>8.00 D)\n\nChildren with axial length out of the range \\[18-34 mm\\]","4 Years",{"count":343,"type":22},378,[25],"The purpose of this clinical investigation is to evaluate the clinical utility of a multifunctional measuring device for Ophtalmology.\n\nThe results of this clinical investigation will be used to refine and validate the device design.\n\n378 participants total will be included in the trial, each having only one visit at the investigation center.",[347,348,158,349,350,351,352],"Accommodation Disorder","Keratoconus","Refractive Errors","Accommodative Fatigue","Accommodative Inertia","Aberration, Corneal Wavefront","2024-08-19",{"date":355,"type":33},"2024-08-21",{"date":357,"type":33},"2024-06-10",{"date":359,"type":22},"2025-08",{"name":39,"class":40},""]