[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Esther Dupont-Versteegden\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":45},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":29,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100480539","muscle-recovery-after-critical-illness-100480539",false,"NCT05537298","Muscle Recovery After Critical Illness","Cellular and Physical Function Outcomes Leading to Failed Muscle Recovery After Critical Illness\u002FMuscle and Physical Functional Recovery After Acute Critical Illness","TRACER","Inclusion Criteria:\n\n* adult (\\>18 y\u002Fo)\n* admission for sepsis or acute respiratory failure with at least 72 hour stay in ICU\n\nExclusion Criteria:\n\n* patients who were not ambulatory prior to ICU admission\n* experienced \\>2 ICU admissions in the past year (chronic or recurrent critical illness due to the same or different reason\n* patients not expected to survive \\~6months after admission\n* acute or chronic neurologic condition\n* acute or chronic orthopedic condition preventing strength\u002Ffunctional testing\n* morbid obesity \\>50 kg\u002Fm2 due to distortion of muscle ultrasonography","MALE","18 Years",{"count":20,"type":21},209,"ESTIMATED","OBSERVATIONAL","The overarching goal of the proposed study is to determine the trajectories of physical recovery and cellular markers involved with the underlying failure to recover muscle after critical illness, while exploring which characteristics are associated with sustained physical disability. This proposal will examine muscle pathophysiology carefully aligned with physical function outcomes in order to longitudinally assess the recovery, or failed recovery, of muscle function in participants after critical illness:\n\n1. to examine the recovery of muscle and physical function in ICU survivors through longitudinal assessments\n2. to investigate the underlying cellular markers and mechanisms of muscle recovery in ICU survivors\n3. to determine which cellular markers contribute to physical disability in ICU survivors up to 1 year after hospital admission",[25,26,27,28],"ICU Acquired Weakness","Post Intensive Care Unit Syndrome","Muscle Weakness","Critical Illness",[30,31],"skeletal muscle","physical function","RECRUITING","2026-06-23",{"date":35,"type":36},"2026-06-26","ACTUAL",{"date":38,"type":36},"2022-10-18",{"date":40,"type":21},"2027-08-01",{"name":42,"class":43},"Esther Dupont-Versteegden","OTHER",3,""]