[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"European Society for Trauma and Emergency Surgery\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":73},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,44],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":25,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100636622","snapchole-an-international-time-bound-prospective-platform-study-of-management-strategies-and-outcomes-in-acute-calculous-cholecystitis-100636622",false,"NCT07568080","SnapChole: An International, Time-Bound Prospective Platform Study of Management Strategies and Outcomes in Acute Calculous Cholecystitis","SnapChole","Inclusion Criteria:\n\n* Age ≥18 years\n* Presentation with suspected acute calculous cholecystitis\n* Diagnosis confirmed prospectively according to Tokyo Guidelines 2018 (TG18) diagnostic criteria\n* Classified as severe (TG18 Grade III) disease based on the presence of organ dysfunction\n* Managed at a participating center during the study accrual period\n\nExclusion Criteria:\n\n* Acalculous cholecystitis\n* Isolated choledocholithiasis or acute cholangitis without cholecystitis\n* Primary gallstone pancreatitis without concomitant acute cholecystitis\n* Elective admission for chronic biliary symptoms\n* Prior cholecystectomy","ALL","18 Years",{"count":19,"type":20},1500,"ESTIMATED","OBSERVATIONAL","This study aims to understand how different treatment approaches for acute gallbladder inflammation (acute calculous cholecystitis) affect patient outcomes in real-world hospital settings.\n\nAcute calculous cholecystitis is a common condition that occurs when gallstones block the gallbladder and cause infection or inflammation. In more severe cases, patients may develop organ dysfunction, and doctors must decide quickly how best to treat the condition. Treatment options include early surgery to remove the gallbladder, placement of a drainage tube, or treatment with antibiotics alone. The best approach is not always clear, especially for patients who are older, have other medical conditions, or are very unwell.\n\nThis study will collect information from hospitals around the world about how patients with severe gallbladder inflammation are treated as part of their usual care. No treatments are assigned by the study. All decisions are made by the patient's clinical team.\n\nThe goal is to compare outcomes between different treatment approaches in patients who could reasonably receive more than one option. The study will examine recovery, survival, need for additional procedures, and time spent in the hospital over 90 days.\n\nThe findings are intended to help doctors and patients better understand which treatment strategies may lead to better outcomes in different clinical situations, and to improve decision-making in emergency surgical care.",[24],"Cholecystitis, Acute",[26,27,28,29,30],"cholecystitis","high-risk","cholecystectomy","percutaneous cholecystostomy","target trial emulation","NOT_YET_RECRUITING","2026-04-29",{"date":34,"type":35},"2026-05-05","ACTUAL",{"date":37,"type":20},"2026-08-01",{"date":39,"type":20},"2028-01-01",{"name":41,"class":42},"European Society for Trauma and Emergency Surgery","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":50,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":52,"targetDuration":54,"studyType":21,"phases":4,"briefSummary":55,"conditions":56,"keywords":58,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":4},"100628225","international-multi-center-profile-of-emergency-large-bowel-obstruction-management-and-outcomes-100628225","NCT07458867","International Multi-center Profile of Emergency Large-Bowel Obstruction Management and Outcomes","International Multi-center Profile of Emergency Large-Bowel Obstruction Management and Outcomes (IMPEL)","IMPEL","Inclusion Criteria:\n\n* Age 18 years or older\n* Hospital admission with mechanical large-bowel obstruction, with or without associated perforation\n* Managed operatively or non-operatively according to local standard practice\n\nExclusion Criteria:\n\n* Functional or pseudo-obstruction without a mechanical lesion\n* Pediatric patients (\\\u003C18 years)\n* Patients not admitted to hospital\n* Isolated large-bowel perforation unrelated to obstruction",{"count":53,"type":20},500,"6 Months","Mechanical large-bowel obstruction is a common and high-risk emergency surgical condition with substantial variation in diagnostic evaluation, operative timing, and management strategies across institutions and healthcare systems. Evidence guiding optimal management remains limited and is largely derived from retrospective or single-center studies.\n\nIMPEL is an international, multicenter, time-bound, prospective observational cohort study designed to characterize real-world presentation, diagnostic pathways, operative and non-operative management, and short-term outcomes in adults presenting with mechanical large-bowel obstruction. By capturing standardized patient-level, radiologic, operative, and outcome data across diverse acute care settings, IMPEL aims to describe contemporary practice patterns, quantify variation in care, and identify factors associated with morbidity, mortality, and stoma-related outcomes.",[57],"Large Bowel Obstruction",[59,60,61,62,63,64],"Large-bowel obstruction","stoma","colonic obstruction","bridge to surgery","snapshot audit","observational cohort","2026-03-04",{"date":67,"type":35},"2026-03-09",{"date":69,"type":20},"2026-07-01",{"date":71,"type":20},"2027-07-31",{"name":41,"class":42},""]