[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Evangelismos Hospital\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":104},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,44,75],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100570467","cpet-guided-rehab-vs-physiotherapy-in-patients-with-dysfunctional-breathing-100570467",false,"NCT06707623","CPET Guided Rehab vs Physiotherapy in Patients With Dysfunctional Breathing","Cardiopulmonary Exercise Testing Guided Physiotherapy During Pulmonary Rehabilitation in Patients With Dysfunctional Breathing, a Randomized Controlled Trial","DB-REHAB","Inclusion Criteria:\n\n* Dysfunctional breathing (DB) diagnosed with CPET.\n* Adult patients (\\>18 years of age)\n* Able and willing to attend an outpatient multidisciplinary, supervised rehabilitation program of a total duration of two months (8 weeks).\n* Able and willing to attend 5 physiotherapy sessions over a period of 9 weeks.\n* Sign an informed consent.\n\nExclusion Criteria:\n\n* No underling pathology explaining dyspnea and DB in CPET (e.g normal dead space to tidal volume ratio (VD\u002FVt) and normal alveolar-arterial (A-a) gradient.)\n* Patients with COPD\n* Patients with uncontrolled asthma\n* Patients with post-exertional malaise (PEM).\n* Patients that cannot attend an outpatient rehabilitation program like suffering from dementia, chronically paralyzed, with paraplegia, multiple injuries, or other serious orthopaedic problems that cause disability or suffer from very serious underlying diseases such as end-stage cancer, and patients with neurological diseases that cause disability, require specialized rehabilitation clinics and special interventions (speech therapy, kinesiotherapy, etc.).","ALL","18 Years",{"count":20,"type":21},78,"ESTIMATED","INTERVENTIONAL",[24],"NA","In this study the efficacy of a pulmonary rehabilitation program tailored to the needs of patients with dysfunctional breathing (DB) will be investigated using cardiopulmonary exercise testing. The pulmonary rehabilitation program will be compared with physiotherapy which is currently the mainstream therapy of DB.",[27],"Dysfunctional Breathing",[27,29,30],"Pulmonary Rehabilitation","Breathing retraining","RECRUITING","2026-04-13",{"date":34,"type":35},"2026-04-14","ACTUAL",{"date":37,"type":35},"2024-11-27",{"date":39,"type":21},"2028-11-30",{"name":41,"class":42},"Evangelismos Hospital","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":48,"acronym":49,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":51,"targetDuration":53,"studyType":54,"phases":4,"briefSummary":55,"conditions":56,"keywords":59,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":43},"100450821","endotyping-prehospital-de-novo-acute-hypoxemic-respiratory-failure-100450821","NCT05150483","EndotyPIng PreHospitAl de Novo Acute hYpoxemic Respiratory Failure","EPIPHANY","Inclusion Criteria:\n\n* Adult patients (aged \\>18 years) presenting in the emergency department\n* De novo acute hypoxemic respiratory failure (requiring oxygen flow rate of 5 liters per minute or more to maintain SpO2 of 90% or more)\n\nExclusion Criteria:\n\n* Age \\\u003C18 years\n* Not admitted to the hospital\n* Postoperative acute respiratory failure (within one week from surgery)\n* Chronic hypoxemic respiratory failure (requiring long term oxygen therapy at home)\n* Hypercapnic respiratory failure\n* Transferred from another hospital or facility\n* Pregnant women\n* Admitted to the hospital purely to facilitate comfort care\n* Lack of informed consent",{"count":52,"type":21},250,"28 Days","OBSERVATIONAL","We attempt to perform dynamic endotyping of critically ill patients presenting in the emergency department with de novo acute hypoxemic respiratory failure (AHRF). We also attempt to identify what clinical, radiological, physiological and biological variables collected early in the course of AHRF correlate with subsequent mortality and\u002For persistent severe hypoxemia.",[57,58],"Acute Hypoxemic Respiratory Failure","Acute Respiratory Distress Syndrome",[60,61,62,63,64,65,66],"critical illness","intensive care unit","endotypes","phenotypes","emergency department","trajectory","mechanical ventilation","2025-08-04",{"date":69,"type":35},"2025-08-07",{"date":71,"type":35},"2021-12-10",{"date":73,"type":21},"2026-04-30",{"name":41,"class":42},{"id":76,"slug":77,"hasResults":11,"nctId":78,"briefTitle":79,"officialTitle":79,"acronym":80,"eligibilityCriteria":81,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":82,"targetDuration":4,"studyType":22,"phases":84,"briefSummary":85,"conditions":86,"keywords":89,"overallStatus":95,"whyStopped":4,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":43},"100599290","effect-of-ventilation-mode-in-the-pupillary-light-reflex-a-crossover-study-100599290","NCT07082569","Effect of Ventilation Mode in the Pupillary Light Reflex: A Crossover Study","EYE-BREATH","Inclusion Criteria\n\n* Adult patients (≥18 years old)\n* Receiving positive-pressure mechanical ventilation\n* Under light or no sedation (e.g., RASS score between -2 and 0)\n* Clinically assessed by the treating physician as not yet ready for weaning from mechanical ventilation\n* Hemodynamically stable at the time of measurement\n* Presence of an arterial catheter in place for blood gas analysis\n* Written informed consent obtained from the patient's legal representative Exclusion Criteria\n* Acute or chronic neurological disease affecting brainstem function or pupillary responses\n* Dyssynchrony with the ventilator or need for high ventilatory support adjustments\n* Facial injuries, edema, or conditions precluding accurate pupillometry\n* Use of neuromuscular blocking agents within the prior 6 hours\n* Severe metabolic or acid-base imbalances that may influence autonomic regulation\n* Concurrent participation in another interventional study that could affect neurological or autonomic outcomes",{"count":83,"type":21},36,[24],"The goal of this clinical trial is to explore whether different modes of mechanical ventilation affect pupillary constriction velocities in critically ill patients without brain injury. The study aims to determine whether the type of mechanical ventilation (volume control, pressure control, or pressure-regulated volume control) influences the maximum and mean constriction velocity measured by automated pupillometry. The trial also investigates whether changes in pupil dynamics reflect subtle alterations in brainstem-autonomic interaction induced by ventilation mode.\n\nThe comparison involves volume control, pressure control, and pressure-regulated volume control in a randomized crossover design to assess whether ventilation mode has a measurable effect on pupil response.\n\nEligible participants will be intubated ICU patients receiving assist control ventilation who are not yet ready for spontaneous breathing trials. Serial pupillometry measurements will be conducted while participants are ventilated with each mode for at least 15 minutes. Sedation and lighting conditions will remain consistent throughout the protocol. Participants with acute or chronic neurologic conditions or ventilator dyssynchrony will be excluded.",[87,88],"Mechanical Ventilation","Critical Illness",[90,91,92,93,94],"Critical illness","Mechanical ventilation","Pupillary light reflex","Automated pupillometry","Neurological Pupil Index","NOT_YET_RECRUITING","2025-07-23",{"date":98,"type":35},"2025-07-24",{"date":100,"type":21},"2025-07-15",{"date":102,"type":21},"2026-09-30",{"name":41,"class":42},""]