[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Evelyn Vanina Re\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":46},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":5},"100625552","remidep-hta-program-for-hypertension-remission-and-medication-deprescription-100625552",false,"NCT07424118","REMIDEP-HTA Program for Hypertension Remission and Medication Deprescription","Efficacy of the REMIDEP-HTA Program in Hypertension Remission and Pharmacological Deprescription: A Multicenter Randomized Clinical Trial","REMIDEP-HTA","Inclusion Criteria \\\u003Cbr\\>\\\u003Cbr\\> Men and women aged 40 to 65 years. \\\u003Cbr\\>\\\u003Cbr\\> Confirmed diagnosis of chronic essential hypertension established at least 6 months prior to enrollment.\n\n\\\u003Cbr\\>\\\u003Cbr\\> Stable antihypertensive pharmacological treatment for at least 3 months prior to enrollment, with no changes in medications or dosages.\n\n\\\u003Cbr\\>\\\u003Cbr\\> Blood pressure at screening ≤ 160\u002F100 millimeters of mercury (mmHg). \\\u003Cbr\\>\\\u003Cbr\\> Ability and willingness to comply with the 12-week behavioral intervention, attend scheduled coaching sessions (60-minute group sessions and 10-minute rescue sessions), perform home blood pressure monitoring, and attend clinical visits according to the study schedule.\n\n\\\u003Cbr\\>\\\u003Cbr\\> Access to an electronic device with internet connectivity sufficient to participate in virtual coaching sessions and to receive and use the program digital materials.\n\n\\\u003Cbr\\>\\\u003Cbr\\> Exclusion Criteria \\\u003Cbr\\>\\\u003Cbr\\> Secondary hypertension. \\\u003Cbr\\>\\\u003Cbr\\> Use of antihypertensive medications for indications other than treatment of hypertension, or use of non-oral antihypertensive therapy.\n\n\\\u003Cbr\\>\\\u003Cbr\\> Medical conditions requiring mandatory continuation of antihypertensive therapy for indications other than blood pressure control, precluding medication reduction or withdrawal.\n\n\\\u003Cbr\\>\\\u003Cbr\\> Physical limitation preventing participation in light-to-moderate intensity physical activity.\n\n\\\u003Cbr\\>\\\u003Cbr\\> Body mass index (BMI) \\\u003C 18.5 kg\u002Fm² or clinical diagnosis of malnutrition. \\\u003Cbr\\>\\\u003Cbr\\> Hospitalization for any cardiovascular cause within 12 months prior to enrollment.\n\n\\\u003Cbr\\>\\\u003Cbr\\> Pregnancy, breastfeeding, or planned pregnancy during the study period. \\\u003Cbr\\>\\\u003Cbr\\> Participation in another interventional clinical study. \\\u003Cbr\\>\\\u003Cbr\\> Cognitive impairment, dementia, severe psychiatric disorder, or other condition that prevents adherence to study procedures or reliable communication with the research team.\n\n\\\u003Cbr\\>\\\u003Cbr\\> Alcohol or illicit substance abuse within the previous 12 months. \\\u003Cbr\\>\\\u003Cbr\\> Any medical condition that, in the investigator's opinion, compromises participant safety or the feasibility of medication deprescribing.","ALL","40 Years","65 Years",{"count":21,"type":22},240,"ESTIMATED","INTERVENTIONAL",[25],"NA","The REMIDEP-HTA trial is a multicenter randomized controlled study designed to evaluate whether a structured approach combining an intensive lifestyle intervention with a systematic deprescribing algorithm can achieve clinical remission of essential hypertension.\n\n\\\u003Cbr\\>\\\u003Cbr\\>\n\nThe intervention integrates a 12-week high-intensity behavioral program focused on whole-food plant-based nutrition, progressive physical activity, sleep hygiene, and stress management, together with a hierarchical, safety-centered medication tapering protocol for antihypertensive therapy.\n\n\\\u003Cbr\\>\\\u003Cbr\\>\n\nThe study aims to determine whether remission can be achieved through a standardized and monitored strategy that prioritizes clinical safety during medication withdrawal.",[28],"Essential Hypertension",[30,31,32,15,33],"Hypertension","Remission","Lifestyle Medicine","Deprescribing Algorithm","NOT_YET_RECRUITING","2026-02-13",{"date":37,"type":38},"2026-02-20","ACTUAL",{"date":40,"type":22},"2026-04",{"date":42,"type":22},"2026-12",{"name":44,"class":45},"Evelyn Vanina Re","OTHER",""]