[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Evidence In Motion\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":119},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,54,80],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":28,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":43,"lastUpdatePostDateStruct":44,"startDateStruct":47,"completionDateStruct":49,"leadSponsor":51,"locationsCount":4},"100614917","virtual-mckenzie-exercises-and-centralization-of-pain-a-pilot-study-100614917",false,"NCT07285824","Virtual McKenzie Exercises and Centralization of Pain: A Pilot Study","Inclusion Criteria:\n\nAge 18 to 65 years\n\nPresenting to outpatient physical therapy with low back pain (LBP)\n\nAble to read and understand English\n\nNo red flags identified during review of systems and initial physical therapy evaluation\n\nNo prior spinal surgery\n\nDemonstrates a positive response to extension-based directional preference testing\n\nWilling and able to provide written informed consent\n\nExclusion Criteria:\n\nAge younger than 18 or older than 65\n\nInability to read or understand English\n\nPresence of red flags during review of systems (e.g., suspected fracture, malignancy, infection, cauda equina symptoms)\n\nHistory of spinal surgery\n\nNo demonstrable directional preference for extension during evaluation\n\nAny condition that the evaluating clinician determines would preclude safe participation\n\nDeclines to participate or is unable to provide informed consent","ALL","18 Years","65 Years",{"count":19,"type":20},40,"ESTIMATED","INTERVENTIONAL",[23],"NA","Low back pain (LBP) is frequently managed in physical therapy using the McKenzie method, in which a patient's directional preference-most commonly extension-is used to guide treatment. Extension-based interventions are associated with symptom improvement and centralization in many individuals with LBP. At the same time, research in pain neuroscience has shown that people with LBP may have altered cortical representations of the low back, which may contribute to pain and disability. For patients who experience high pain levels or significant fear of movement, active directional preference exercises may be difficult to perform.\n\nMotor imagery, the mental simulation of movement without physical execution, has been shown to activate brain regions involved in movement and may help modify altered cortical representations. Preliminary research has suggested that virtual or imagery-based McKenzie extension exercises may improve pain and movement-related outcomes.\n\nThis exploratory study aims to evaluate the immediate effects of a brief motor imagery-based extension protocol in adults with LBP who demonstrate a directional preference for extension. The study will assess changes in pain intensity, disability, fear-avoidance, pain catastrophization, lumbar flexion, straight leg raise, pain distribution, and symptom centralization following a single motor imagery session.",[26,27],"Chronic Pain","Low Back Pain",[27,26,29,30,31,32,33,34,35,36,37,38,39,40,41],"Directional Preference","McKenzie Method","Extension-Based Exercise","Motor Imagery","Virtual Exercise","Pain Centralization","Fear-Avoidance","Pain Catastrophization","Physical Therapy","Cortical Representation","Somatosensory Cortex (S1)","Body Schema","Disability","NOT_YET_RECRUITING","2025-12-03",{"date":45,"type":46},"2025-12-16","ACTUAL",{"date":48,"type":20},"2025-12",{"date":50,"type":20},"2026-11",{"name":52,"class":53},"Evidence In Motion","OTHER",{"id":55,"slug":56,"hasResults":11,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":60,"eligibilityCriteria":61,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":62,"targetDuration":4,"studyType":21,"phases":64,"briefSummary":65,"conditions":66,"keywords":67,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":4},"100612362","pain-neuroscience-education-and-memory-100612362","NCT07252596","Pain Neuroscience Education and Memory","Pain Neuroscience Education's Effect on Memory and Pain Drawings: An Exploratory Study","PNE","Inclusion Criteria:\n\n* Age 18 and above\n* Chronic pain \\> 1 year\n* Provide written consent\n* Proficient in reading and understanding English\n\nExclusion Criteria:\n\n* Not willing to participate in the study\n* Have received PNE as a treatment before",{"count":63,"type":20},50,[23],"Brief Summary:\n\nThe goal of this observational study (case series) is to determine whether Pain Neuroscience Education (PNE) can influence memory function and sensory awareness in adults (18 years and older) experiencing chronic pain lasting more than one year.\n\nThe main questions it aims to answer are:\n\nDoes a single PNE session improve memory performance, as measured by the Montreal Cognitive Assessment (MoCA)?\n\nDoes PNE change sensory awareness, as represented by alterations in body pain drawings using a grid overlay method?\n\nParticipants will:\n\nComplete pre-intervention assessments, including:\n\nNumeric Pain Rating Scale (NPRS)\n\nBody chart drawing to map pain area\n\nMontreal Cognitive Assessment (MoCA)\n\nPain Catastrophization Scale (PCS)\n\nReceive a 10-15 minute standardized PNE session delivered by a licensed clinician trained in pain science\n\nComplete the same assessments immediately after the intervention to identify any changes in memory, sensory awareness, and pain perception\n\nThis study aims to explore whether PNE can positively impact cognitive and sensory functions affected by chronic pain, beyond its already-established effects on movement and pain intensity.",[26],[68,69,70,71],"pain neuroscience education","Memory","Pain drawing","chronic pain","2025-11-24",{"date":74,"type":46},"2025-11-26",{"date":76,"type":20},"2025-11",{"date":78,"type":20},"2026-05",{"name":52,"class":53},{"id":81,"slug":82,"hasResults":11,"nctId":83,"briefTitle":84,"officialTitle":85,"acronym":86,"eligibilityCriteria":87,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":88,"targetDuration":4,"studyType":21,"phases":89,"briefSummary":90,"conditions":91,"keywords":96,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":112,"lastUpdatePostDateStruct":113,"startDateStruct":115,"completionDateStruct":116,"leadSponsor":118,"locationsCount":4},"100612081","contralateral-neural-tissue-mobilization-for-cervical-radiculopathy-100612081","NCT07248943","Contralateral Neural Tissue Mobilization for Cervical Radiculopathy","Contralateral Neural Tissue Mobilization for Cervical Radiculopathy: An Exploratory Study","NTM","Inclusion Criteria:\n\n* Age 18 years or older Presence of unilateral upper-extremity pain in a dermatomal distribution consistent with cervical radiculopathy (with or without neck pain)\n* Able to read and understand English\n* Willing and able to provide written informed consent\n* New patient to the clinic or established patient who meets inclusion criteria and has not previously received neural tissue mobilization as part of treatment\n\nExclusion Criteria:\n\n* Bilateral upper-extremity pain\n* Upper-extremity pain that is non-dermatomal in distribution\n* Presence of contraindications or precautions preventing use of the contralateral limb for neural tissue mobilization (e.g., injury, allodynia, recent surgery, postsurgical complications)\n* Not willing to participate in the study",{"count":19,"type":20},[23],"Cervical radiculopathy (CR) is a common form of peripheral neuropathic pain characterized by neck and upper extremity symptoms in a dermatomal distribution. Neural tissue mobilization (NTM) is an intervention shown to provide benefit for neuropathic pain presentations; however, some patients are unable to tolerate direct treatment of the symptomatic limb due to allodynia, hyperalgesia, or fear of movement. Early evidence from lower-extremity research suggests that contralateral NTM may produce therapeutic effects similar to ipsilateral treatment, but this approach has not been investigated in individuals with upper-extremity symptoms.\n\nThis exploratory case series aims to examine the immediate effects of contralateral NTM in adults presenting to outpatient physical therapy with CR. Participants will undergo pre- and post-treatment assessments of pain intensity, disability, fear-avoidance beliefs, pain distribution, and neurodynamic mechanosensitivity. Findings will provide preliminary evidence regarding whether contralateral NTM may serve as a viable treatment option when direct symptomatic limb treatment is not tolerated.",[92,93,94,95],"Cervical Radiculopathy","Pain","Neuropathic Pain","Radicular Pain",[92,94,97,98,95,99,100,101,102,103,104,105,106,37,107,108,109,110,111],"Peripheral Neuropathic Pain","Upper Extremity Pain","Cervical Spine Disorders","Nerve Root Compression","Neural Tissue Mobilization","Neurodynamic Mobilization","Neurodynamics","Contralateral Treatment","Median Nerve Mobilization","Upper Limb Neurodynamic Test (ULNT1a)","Musculoskeletal Pain","Pain Phenotyping","Manual Therapy","Rehabilitation","Mechanosensitivity","2025-11-18",{"date":114,"type":46},"2025-11-25",{"date":48,"type":20},{"date":117,"type":20},"2026-09",{"name":52,"class":53},""]