[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Exosystems\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":65},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,46],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":4},"100644034","clinical-trial-to-evaluate-the-efficacy-of-neuromuscular-electrical-stimulation-therapy-in-patients-with-sarcopenia-100644034",false,"NCT07668258","Clinical Trial to Evaluate the Efficacy of Neuromuscular Electrical Stimulation Therapy in Patients With Sarcopenia","A Single-Center, Randomized, Double-Blind, Sham-Controlled Clinical Trial to Evaluate the Efficacy of Neuromuscular Electrical Stimulation Therapy for Improving Lower-Limb Strength and Physical Performance in Patients With Sarcopenia","NMES","Inclusion Criteria:\n\n1. Diagnosed with sarcopenia according to the Asian Working Group for Sarcopenia (2019) criteria\n2. Able to perform the exercise program provided by the investigators, with sufficient physical and cognitive function\n3. Able to understand the study explanation and provide voluntary informed consent\n4. Able to operate a mobile phone independently or with assistance from a caregiver\n\nExclusion Criteria:\n\n1\\) History of Knee Surgery\n\n* Any prior surgical procedure on either knee (right or left) 2) Recent Knee Injection or Procedure\n* Receipt of any injection or interventional procedure in either knee within the past 3 months 3) Ongoing Treatment for Knee Pain\n* Currently receiving medication or physical therapy for knee pain 4) Implanted Electrical Devices\n* Presence of an implanted electrical device (e.g., pacemaker, electrical stimulator) 5) Seizure Disorder\n* Current or past history of seizures requiring medication 6) Severe Peripheral Arterial Disease\n* Significant arterial circulatory disorder in the lower extremities 7) Hernia\n* Presence of abdominal or inguinal hernia 8) Difficulty Operating Devices\n* Difficulty operating medical devices or mobile phones 9) Metal Allergy\n* Known metal allergy that interferes with device application 10) Skin Lesions on Thigh\n* Skin conditions on the thigh (e.g., burns, scars) that interfere with electrical stimulation 11) Suspected Infection on Thigh\n* Signs suggestive of infection on the thigh (e.g., erythema, warmth) 12) Impaired Sensation at Patch Site\n* Reduced sensation at the patch site preventing adequate self-reporting 13) End-stage Organ Failure\n* Diagnosis of end-stage heart failure or end-stage renal disease requiring dialysis 14) Abnormal Laboratory Findings\n* Any of the following (based on the most recent test within 6 months; if unavailable, a screening CBC will be performed):\n\n  * Platelet count \\\u003C 50,000\u002FμL\n  * Hemoglobin \\\u003C 8.0 g\u002FdL\n  * Absolute neutrophil count \\\u003C 1,000\u002FμL 15) Impaired Ambulation\n* Difficulty walking due to visual impairment, fracture, severe muscle paralysis, dizziness, or other causes 16) Inability to Participate in Rehabilitation Exercise\n* Judged by the investigator as unable to participate in rehabilitation exercise For example, diagnosis of Cachexia, defined as: Unintentional weight loss ≥ 5% within the past 6 months, or BMI \\\u003C 20 kg\u002Fm² with ≥ 2% weight loss 17) Withdrawal or Lack of Consent 18) Other Reasons\n* Any other condition deemed by the investigator to make the participant unsuitable for participation in this clinical trial","ALL","50 Years","85 Years",{"count":21,"type":22},40,"ESTIMATED","INTERVENTIONAL",[25],"NA","The goal of this clinical trial is to exploratorily evaluate the safety and efficacy of a home-based lower extremity muscle strengthening and physical performance enhancement program using Neuromuscular Electrical Stimulation (NMES) devices.\n\nParticipants will apply NMES stimulation to both thighs for 8 weeks, at a frequency of at least 4 times per week.",[28],"Sarcopenia",[30,31,32,33],"sarcopenia","muscle mass","knee strength","Physical Performance","NOT_YET_RECRUITING","2026-06-21",{"date":37,"type":38},"2026-06-25","ACTUAL",{"date":40,"type":22},"2026-06-09",{"date":42,"type":22},"2027-02",{"name":44,"class":45},"Exosystems","INDUSTRY",{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":4,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":53,"targetDuration":4,"studyType":23,"phases":55,"briefSummary":56,"conditions":57,"keywords":4,"overallStatus":58,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":59,"startDateStruct":60,"completionDateStruct":62,"leadSponsor":64,"locationsCount":5},"100617496","evaluation-of-safety-and-efficacy-of-a-digital-therapeutic-device-to-improve-strength-in-sarcopenia-sarc-dtx-100617496","NCT07319377","Evaluation of Safety and Efficacy of a Digital Therapeutic Device to Improve Strength in Sarcopenia (Sarc-DTx)","A Multicenter, Prospective, Randomized, Parallel-Group, Double-blinded, Confirmatory Clinical Trial to Evaluate the Safety and Efficacy of a Digital Therapeutic Device for Improving Muscle Strength in Patients With Sarcopenia","Inclusion Criteria\n\n* Individuals diagnosed with sarcopenia according to both the European Working Group on Sarcopenia in Older People (EWGSOP) criteria and the Asian Working Group for Sarcopenia 2019 (AWGS 2019) criteria\n* Individuals with reduced muscle strength, defined as at least one of the following:\n* Handgrip strength \\\u003C 28 kg for men or \\\u003C 18 kg for women\n* Five-times Sit-to-Stand Test time \\> 12 seconds without arm support\n* Individuals with reduced muscle mass, defined as at least one of the following:\n* Skeletal Muscle Mass Index (SMI) \\\u003C 7.0 kg\u002Fm² for men or \\\u003C 5.4 kg\u002Fm² for women measured by DXA\n* Skeletal Muscle Mass Index (SMI) \\\u003C 7.0 kg\u002Fm² for men or \\\u003C 5.7 kg\u002Fm² for women measured by BIA\n* Individuals able to independently perform sit-to-stand movements\n* Individuals with sufficient physical and cognitive capacity to participate in the exercise program\n* Individuals able and willing to provide written informed consent\n* Individuals able to operate a mobile phone independently or with assistance from a caregiver\n\nExclusion Criteria\n\n* Individuals with cognitive impairment, defined as a Mini-Mental State Examination (MMSE) score \\\u003C 20, or those unable to participate due to cognitive decline\n* Individuals with an implanted cardiac pacemaker or other implanted electronic medical device\n* Individuals with uncontrolled cardiovascular disease despite appropriate medical management\n* Individuals who have undergone lower-limb surgery within the past 6 months and are unable to ambulate independently\n* Individuals with moderate-to-severe musculoskeletal pain or functional limitations that interfere with objective functional assessments\n* Individuals with severe obesity, defined as a body mass index (BMI) \\> 50 kg\u002Fm²\n* Individuals currently receiving active cancer treatment or experiencing severe systemic frailty\n* Individuals with hemiplegia that prevents participation in the prescribed exercise program\n* Individuals who are anticipated by the investigator to be unable to complete the study procedures or follow-up assessments\n* Individuals unable to understand or comply with study instructions provided in Korean\n* Individuals considered unsuitable for study participation at the discretion of the investigator for any other reason",{"count":54,"type":22},130,[25],"This clinical trial aims to demonstrate that the use of a digital therapeutic device (exoDTx) in patients with sarcopenia is superior to self-exercise in terms of muscle strength improvement and safety.",[28],"RECRUITING",{"date":37,"type":38},{"date":61,"type":38},"2025-11-28",{"date":63,"type":22},"2026-12-30",{"name":44,"class":45},""]