[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Fangbiao Tao\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":189},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,7,0,[8,48,76,100,123,143,169],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":31,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100639722","effectiveness-of-an-ai-enabled-mobile-intervention-on-lifestyle-behaviors-and-maternal-infant-health-100639722",false,"NCT07582068","Effectiveness of an AI-Enabled Mobile Intervention on Lifestyle Behaviors and Maternal-Infant Health","Effects of an AI-driven Mobile Health Management Intervention to Prevent Gestational Diabetes Mellitus in High-risk Pregnant Women: A Pragmatic Randomized Controlled Trial","Inclusion Criteria:\n\n* Pregnant women aged ≥18 years\n* Singleton pregnancy\n* Gestational age \\\u003C13+6 weeks at enrollment\n* At least one of the following GDM risk factors:\n\n  1. Age ≥35 years\n  2. Pre-pregnancy BMI ≥24 kg\u002Fm²\n  3. Family history of diabetes (first-degree relatives)\n  4. Previous history of gestational diabetes mellitus\n  5. Prior delivery of a macrosomic infant (birth weight ≥4000 g)\n* Polycystic ovary syndrome\n* Use of an Android smartphone\n* No severe heart, liver, or kidney diseases\n* Voluntary participation and signed informed consent\n\nExclusion Criteria:\n\n* Pre-pregnancy diagnosis of diabetes mellitus (type 1 or type 2)\n* Severe mental illness\n* Confirmed severe pregnancy complications (e.g., preeclampsia, placental abruption, etc.)\n* Inability to complete questionnaires or intervention\n* Participation in other interventional studies",true,"FEMALE","18 Years",{"count":20,"type":21},400,"ESTIMATED","INTERVENTIONAL",[24],"NA","The goal of this pragmatic randomized controlled trial is to evaluate the effectiveness of an AI-enabled mobile health management application (\"Better Pregnancy\" app), grounded in the Theory of Planned Behavior, in preventing gestational diabetes mellitus (GDM) among pregnant women at high risk of GDM, and to assess its impact on maternal and infant health outcomes.\n\nStudy Population: Eligible participants are pregnant women aged 18-49 years, with a singleton pregnancy, gestational age \\\u003C12 weeks at enrollment, and at least one GDM risk factor (age ≥35 years, pre-pregnancy BMI ≥24 kg\u002Fm², family history of diabetes, previous history of GDM, prior delivery of a macrosomic infant \\[birth weight ≥4000 g\\], or polycystic ovary syndrome). Participants must have no heart, liver, or kidney diseases, use an Android smartphone, and provide written informed consent.\n\nThe main questions it aims to answer are:\n\nCan the AI-driven mobile lifestyle intervention reduce the incidence of GDM in high-risk pregnant women?\n\nDoes the intervention improve lifestyle behaviors (diet, physical activity, sleep) and glycemic control (measured by continuous glucose monitoring) in participants?\n\nWhat is the adherence, acceptability, and cost-effectiveness of this intervention in real-world clinical settings?\n\nComparison: Researchers will compare two groups of pregnant women: the intervention group (receiving the AI-enabled \"Better Pregnancy\" app plus routine antenatal care) and the control group (receiving routine antenatal care alone).\n\nParticipants will:\n\nEnroll in the first trimester (\\\u003C12 weeks of gestation) and complete a baseline lifestyle and health status questionnaire\n\nIn the intervention group: watch 7 cognitive-attitudinal videos within the first week, then complete 12 weeks of AI-driven personalized intervention (daily check-ins, receiving tailored recommendations on diet, physical activity, sleep, etc.)\n\nDuring the intervention period, participants in the intervention group will wear a continuous glucose monitoring device for 7 days to assess the impact of the intervention on glycemic fluctuations\n\nComplete the first follow-up lifestyle and health status assessment after the intervention (approximately in the second trimester)\n\nUndergo an oral glucose tolerance test during the second trimester (24-28 weeks)\n\nComplete the second follow-up lifestyle and health status assessment in the third trimester (≥28 weeks)\n\nComplete the third follow-up lifestyle and health status assessment at 42 days postpartum, along with collection of delivery outcomes and infant health information\n\nA subset of participants may voluntarily provide blood and stool samples for mechanistic studies",[27,28,29,30],"Mobile Health Apps","Lifestyle Intervention","Prevention","Multi-component Based Behavioral Intervention",[29,32,33,34],"Gestational diabetes mellitus","Mobile health","Randomized controlled trial","NOT_YET_RECRUITING","2026-05-06",{"date":38,"type":39},"2026-05-12","ACTUAL",{"date":41,"type":21},"2026-08-10",{"date":43,"type":21},"2027-12-31",{"name":45,"class":46},"Fangbiao Tao","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":16,"sex":55,"minAge":56,"maxAge":57,"enrollmentInfo":58,"targetDuration":4,"studyType":22,"phases":60,"briefSummary":61,"conditions":62,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":4},"100629508","effects-of-auricular-point-pressing-with-pellets-in-children-with-insufficient-hyperopia-reserve-100629508","NCT07475585","Effects of Auricular Point Pressing With Pellets in Children With Insufficient Hyperopia Reserve","A Randomized Controlled Trial of Auricular Point Pressing With Pellets for Children With Insufficient Hyperopia Reserve","Inclusion Criteria:\n\n(1) obtaining written informed consent signed by children and legal guardians;(2) children aged 4 to 14 years old;(3) computer optometry after ciliary muscle paralysis detects that the equivalent spherical power of any eye is between -0.50D and 0.75D (4) there are no other organic diseases affecting vision in both eyes;(5) binocular intraocular pressure ≤ 21mmHg.\n\nExclusion Criteria:\n\n(1) subjects who have been diagnosed with myopia (2) subjects who may have eye diseases that affect vision or refractive errors (such as cataract and other lens injury diseases, glaucoma, macular degeneration, keratopathy, retinal detachment, severe vitreous opacity, etc.);(3) systemic diseases: central nervous system diseases, Down syndrome, asthma, severe cardiopulmonary function, 8 severe liver and kidney dysfunction;(4) Binocular or monocular with dominant strabismus or any other pathological changes of the eye or acute inflammatory diseases of the eye;(5) allergic to atropine, compound Tobicamide and other drugs used in this study;(6) those who have participated in clinical trials of other drugs within 3 months before screening;(7) other conditions that the researchers think are not suitable.","ALL","4 Years","14 Years",{"count":59,"type":21},380,[24],"This project aims to address the trend of early onset and high myopia among children in China by focusing on insufficient hyperopia reserve, a key early warning indicator for myopia. A randomized controlled trial (RCT) will be conducted. The study will target children aged 4 to 14 with insufficient hyperopia reserve (equivalent spherical lens -0.50D to +0.75D). Through a prospective RCT design, the efficacy and safety of auricular point pressure therapy, low-concentration atropine eye drops, and their combination in delaying the onset of myopia will be systematically evaluated.",[63,64,65,66,67],"Myopia","Ear Acupressure Pellets","Hyperopia Reserve","Low-concentration Atropine Eye Drops","Eye Axis","2026-03-11",{"date":70,"type":39},"2026-03-16",{"date":72,"type":21},"2026-03-30",{"date":74,"type":21},"2027-07-30",{"name":45,"class":46},{"id":77,"slug":78,"hasResults":11,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":4,"eligibilityCriteria":82,"healthyVolunteers":16,"sex":55,"minAge":83,"maxAge":84,"enrollmentInfo":85,"targetDuration":4,"studyType":22,"phases":87,"briefSummary":88,"conditions":89,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":4},"100615562","intervention-for-preventing-myopia-and-multimorbidity-in-children-100615562","NCT07294222","Intervention for Preventing Myopia and Multimorbidity in Children","Establishment of Appropriate Intervention Methods for Preventing Myopia and Multimorbidity in Children and Conducting a RCT Study","Inclusion Criteria:\n\n* Children in grades 3-4, aged 8-11 years.\n* Informed consent obtained.\n\nExclusion Criteria:\n\n* Presence of systemic diseases (e.g., endocrine, cardiac, psychiatric disorders).\n* Presence of developmental abnormalities.\n* Inability to complete the follow-up.","8 Years","11 Years",{"count":86,"type":21},4000,[24],"This study aims to develop and evaluate a scalable, hybrid intervention model for the co-prevention of myopia, obesity, and mental health issues among children. By integrating cognitive behavioral therapy principles, the model targets key modifiable lifestyle factors-including dietary nutrition, physical activity, screen time, sleep hygiene, light exposure, and psychological adaptation-through coordinated family-school engagement and online-to-offline delivery. Using a cluster randomized controlled trial design in grades 3-4 primary school students, the research will assess the effectiveness of this multi-component strategy in reducing the incidence and burden of these co-occurring conditions.",[63,90,91],"Mental Health","Cardiovascular Health Status","2025-12-18",{"date":94,"type":39},"2025-12-24",{"date":96,"type":21},"2025-12-30",{"date":98,"type":21},"2027-01-30",{"name":45,"class":46},{"id":101,"slug":102,"hasResults":11,"nctId":103,"briefTitle":104,"officialTitle":105,"acronym":4,"eligibilityCriteria":106,"healthyVolunteers":16,"sex":55,"minAge":107,"maxAge":108,"enrollmentInfo":109,"targetDuration":4,"studyType":22,"phases":111,"briefSummary":112,"conditions":113,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":116,"lastUpdatePostDateStruct":117,"startDateStruct":119,"completionDateStruct":121,"leadSponsor":122,"locationsCount":4},"100564022","study-on-the-impact-of-desk-and-chair-adaptation-intervention-on-the-occurrence-and-development-of-myopia-in-primary-school-students-100564022","NCT06623760","Study on the Impact of Desk and Chair Adaptation Intervention on the Occurrence and Development of Myopia in Primary School Students","Intervention Study：Study on the Impact of Desk and Chair Adaptation Intervention on the Occurrence and Development of Myopia in Primary School Students","Inclusion Criteria:\n\n* Students and their families were informed and voluntarily participated in the study, with parents signing the informed consent form.\n* Able to cooperate with eye examinations and questionnaires.\n\nExclusion Criteria:\n\n* Communication barriers, unable to cooperate.\n* Strabismus, amblyopia, or any other ocular or systemic diseases that may affect refractive development.\n* Children currently using orthokeratology lenses or rigid contact lenses.\n* Using other interventions (such as acupuncture, massage, medication, ear acupuncture, etc.) to control myopia, apart from school eye exercises.","6 Years","13 Years",{"count":110,"type":21},2100,[24],"This study is a randomized controlled trial of a desk and chair adaptation intervention involving primary school students and their parents or primary caregivers. We compared the myopia status of students in the intervention and control groups before and after the intervention to confirm the effect of the desk and chair adaptation intervention on the development of myopia in students.",[114,63,115],"Axial Length, Eye","Myopia Progression","2024-09-30",{"date":118,"type":39},"2024-10-02",{"date":120,"type":21},"2024-10-01",{"date":96,"type":21},{"name":45,"class":46},{"id":124,"slug":125,"hasResults":11,"nctId":126,"briefTitle":127,"officialTitle":128,"acronym":4,"eligibilityCriteria":129,"healthyVolunteers":16,"sex":55,"minAge":130,"maxAge":107,"enrollmentInfo":131,"targetDuration":4,"studyType":22,"phases":133,"briefSummary":134,"conditions":135,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":116,"lastUpdatePostDateStruct":137,"startDateStruct":138,"completionDateStruct":140,"leadSponsor":142,"locationsCount":4},"100563752","a-study-of-the-impact-of-digital-intervention-on-parentsprimary-caregivers-myopia-prevention-and-control-health-literacy-on-preschoolers-myopia-and-physical-and-mental-health-100563752","NCT06620250","A Study of the Impact of Digital Intervention on Parents\u002Fprimary Caregivers' Myopia Prevention and Control Health Literacy on Preschoolers' Myopia and Physical and Mental Health","A Randomized Controlled Trial：a Study of the Impact of Digital Intervention on Parents\u002Fprimary Caregivers' Myopia Prevention and Control Health Literacy on Preschoolers' Myopia and Physical and Mental Health","Inclusion Criteria:\n\n* No cognitive impairment and communication impairment\n* Volunteer and sign the informed consent\n* Fill in the questionnaire\n* Skilled in using electronic equipment\n\nExclusion Criteria:\n\n* Children with congenital glaucoma, cataract, strabismus and other congenital eye diseases\n* Children with a history of ocular trauma, eye surgery, or complications of myopia\n* Do not cooperate with the investigation","3 Years",{"count":132,"type":21},882,[24],"The study is a Randomized controlled trial based on digital interventions, involving pre-school children and their parents or major caregivers. To compare the myopia and physical and mental health status of preschool children before and after intervention between intervention group and control group, to confirm the effect of digital intervention on prevention and control of Myopia and physical and mental health of preschool children.",[63,90,136],"Obesity",{"date":120,"type":39},{"date":139,"type":21},"2024-10",{"date":141,"type":21},"2025-12",{"name":45,"class":46},{"id":144,"slug":145,"hasResults":11,"nctId":146,"briefTitle":147,"officialTitle":148,"acronym":4,"eligibilityCriteria":149,"healthyVolunteers":16,"sex":55,"minAge":150,"maxAge":57,"enrollmentInfo":151,"targetDuration":4,"studyType":153,"phases":4,"briefSummary":154,"conditions":155,"keywords":160,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":164,"lastUpdatePostDateStruct":165,"startDateStruct":166,"completionDateStruct":167,"leadSponsor":168,"locationsCount":4},"100563727","the-role-of-after-school-exercise-services-in-promoting-myopia-and-physical-and-mental-health-in-children-100563727","NCT06619925","The Role of After-school Exercise Services in Promoting Myopia and Physical and Mental Health in Children","A Cohort Study of After-school Exercise Services in Promoting Myopia and Physical and Mental Health in Children","Inclusion Criteria:\n\n* ① Those who voluntarily participate in the after-school extended hours service;\n\n  * Those who voluntarily participate in this study and sign the informed consent; ③ Basic reading, writing and comprehension skills to understand the questionnaire and be able to answer it;\n\nExclusion Criteria:\n\n* ① Unfit to participate in sports activities for health or physical reasons; ② Suffering from glaucoma, glaucoma and other diseases.\n\n  * Those who suffer from glaucoma, strabismus, refractive error and other eye diseases that affect vision;","5 Years",{"count":152,"type":21},2000,"OBSERVATIONAL","This project is a prospective cohort study to evaluate the impact of after-school extended physical education services on the visual health, physical health indicators, and mental health of children and adolescents participating in these services over a one-year period. The study collected data on the participation rate, duration, activity content, and organisational form of the after-school extended hours service through a questionnaire; the demographic characteristics, sleeping habits, and dietary habits of the participants through a self-administered questionnaire on the multidisease behaviour of children and adolescents; the intensity of the activities of the students who participated in the after-school extended hours service was investigated through an accelerometer and a physical activity questionnaire; and data on students\\' visual acuity, body mass index, and mental health status were collected through a medical check-up. Students' visual acuity data, body mass index, maximum oxygen uptake, and other indicators of physical health and mental health were collected through physical examination, and data on changes in one year were collected through half-yearly\u002Ffollow-up visits to establish a cohort to evaluate the effects of after-school extended hours services on students' myopia rates, physical health and mental health levels by different types, intensity and duration of exercise.",[156,157,158,159],"Common Diseases","Joint Prevention","Students","After-school Extended Sports Service",[161,162,163],"common diseases","joint prevention","after-school extended sports service","2024-09-28",{"date":120,"type":39},{"date":120,"type":21},{"date":96,"type":21},{"name":45,"class":46},{"id":170,"slug":171,"hasResults":11,"nctId":172,"briefTitle":173,"officialTitle":174,"acronym":4,"eligibilityCriteria":106,"healthyVolunteers":16,"sex":55,"minAge":56,"maxAge":150,"enrollmentInfo":175,"targetDuration":4,"studyType":22,"phases":177,"briefSummary":178,"conditions":179,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":181,"lastUpdatePostDateStruct":182,"startDateStruct":184,"completionDateStruct":186,"leadSponsor":188,"locationsCount":4},"100562782","study-of-the-intervention-effect-of-outdoor-activity-period-patterns-in-promoting-myopia-among-preschool-children-100562782","NCT06607640","Study of the Intervention Effect of Outdoor Activity Period Patterns in Promoting Myopia Among Preschool Children","Study on the Association of Time Pattern of Outdoor Activity With Axial Length and Myopia of Preschool Children and Its Intervention",{"count":176,"type":21},210,[24],"This study is a randomized controlled trial based on outdoor activity interventions at specific time periods, involving preschool children aged 4 to 5 years. It compared the axial length and myopia incidence between the intervention group and the control group at the 6th and 12th months of the intervention to determine the effect of outdoor activities at specific time periods on the prevention of myopia in preschool children. Additionally, the study investigated the association between outdoor activities at specific time periods and axial length and myopia in preschool children.",[180,63],"Axial Length","2024-09-19",{"date":183,"type":39},"2024-09-23",{"date":185,"type":21},"2024-09-21",{"date":187,"type":21},"2025-12-21",{"name":45,"class":46},""]