[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Fatihhan Zeytun\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":40},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":27,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":5},"100642483","pocd-after-major-gynecologic-surgery-100642483",false,"NCT07589348","POCD After Major Gynecologic Surgery","Early Postoperative Cognitive Dysfunction After Major Gynecological Surgery: Incidence and Perioperative Risk Factors in a Prospective Cohort Study","POCD-GYN","Inclusion Criteria:\n\n* Female patients aged ≥18 years\n* Scheduled for elective major gynecological surgery under general anesthesia\n* Total abdominal hysterectomy and\u002For bilateral salpingo-oophorectomy\n* Open or laparoscopic surgical approach\n* Ability to complete the Turkish version of the Montreal Cognitive Assessment (MoCA)\n* Ability to understand and provide written informed consen\n\nExclusion Criteria:\n\n* Pre-existing dementia or major neurocognitive disorder\n* History of cerebrovascular event within the previous 3 months\n* Severe visual or hearing impairment preventing cognitive assessment\n* Emergency or hemodynamically unstable surgery\n* Planned postoperative sedation or mechanical ventilation longer than 72 hours\n* Postoperative delirium detected during assessment\n* Inability to communicate or cooperate\n* Refusal to participate","FEMALE","18 Years",{"count":20,"type":21},72,"ESTIMATED","OBSERVATIONAL","This prospective observational cohort study aims to determine the incidence of early postoperative cognitive dysfunction (POCD) in patients undergoing major gynecological surgery. Cognitive function will be assessed using the Montreal Cognitive Assessment (MoCA) preoperatively and on postoperative day 3. POCD will be defined as a ≥20% relative decline or ≥2-point decrease in MoCA score. The study will also evaluate the association between POCD and perioperative clinical, surgical, and inflammatory parameters.",[25,26],"Postoperative Cognitive Dysfunction","Perioperative Neurocognitive Disorder",[25,26],"RECRUITING","2026-06-11",{"date":31,"type":32},"2026-06-12","ACTUAL",{"date":34,"type":32},"2026-05-06",{"date":36,"type":21},"2026-09-15",{"name":38,"class":39},"Fatihhan Zeytun","OTHER_GOV",""]