[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Fayoum University Hospital\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":278},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,10,0,[8,46,72,99,126,151,176,204,231,254],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100607342","exora-vs-esp-blocks-in-laparoscopic-cholecystectomy-100607342",false,"NCT07187310","EXORA vs ESP Blocks in Laparoscopic Cholecystectomy","The Analgesic Efficacy of EXORA Block Versus Erector Spinae Plane Block in Patients Undergoing Laparoscopic Cholecystectomy Under General Anesthesia","Inclusion Criteria:\n\n* Elective laparoscopic cholecystectomy\n* ASA physical status I-III\n\nExclusion Criteria:\n\n* Known allergy to local anesthetics\n* Chronic pain or regular opioid use\n* Coagulopathy or anticoagulant therapy\n* Local infection at the block site\n* BMI more than 35 kg\u002Fm2\n* Neurological or psychiatric disorders\n* Refusal to participate","ALL","18 Years","65 Years",{"count":20,"type":21},114,"ESTIMATED","INTERVENTIONAL",[24],"NA","Laparoscopic cholecystectomy is still considered the gold standard for the surgical management of gallbladder disease due to its minimally invasive nature, shorter recovery time, and reduced postoperative complications. Despite these advantages, patients frequently experience moderate to severe postoperative pain, particularly in the early postoperative period, which can impede recovery, delay mobilization, and increase opioid consumption. Excessive opioid use after laparoscopic cholecystectomy is associated with several drawbacks, including nausea, vomiting, sedation, and delayed recovery. It also increases the risk of respiratory depression, especially in vulnerable patients, and may contribute to long-term opioid dependence. These risks highlight the importance of opioid-sparing strategies such as regional anesthesia techniques to improve patient outcomes and enhance recovery. Regional anesthesia techniques have emerged as essential components of multimodal analgesia strategies in abdominal surgeries. Among them, the Erector Spinae Plane (ESP) Block has gained popularity due to its relative ease of administration and favorable safety profile.\n\nRecently, a novel fascial plane block known as the EXORA block has been introduced as a promising alternative for abdominal wall analgesia. This block, which targets a different anatomical plane, is postulated to provide comparable or superior analgesic efficacy to traditional methods while maintaining safety and simplicity in execution. Given the ongoing pursuit of optimal analgesia with minimal side effects, it is essential to compare emerging techniques, such as the EXORA block, with established methods like the ESP block.\n\nThe authors hypothesize that the EXORA and the ESP blocks provide superior postoperative analgesia compared to controls in patients undergoing laparoscopic cholecystectomy and that the EXORA block analgesic profile is superior to that of the ESP block.",[27],"Postoperative Pain",[29,30,31,32],"EXORA block","Erector spinae Plain block","Regional Anesthesia for Laparoscopic Cholecystectomy","Postoperative pain management in abdominal surgeries","RECRUITING","2026-05-30",{"date":36,"type":37},"2026-06-02","ACTUAL",{"date":39,"type":37},"2025-12-30",{"date":41,"type":21},"2026-08-01",{"name":43,"class":44},"Fayoum University Hospital","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":4,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":53,"targetDuration":4,"studyType":22,"phases":55,"briefSummary":56,"conditions":57,"keywords":60,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":45},"100635734","comparison-of-serratus-intercostal-plane-blcok-with-erector-spinae-plane-block-for-open-nephrectomy-100635734","NCT07556536","Comparison of Serratus Intercostal Plane Blcok With Erector Spinae Plane Block for Open Nephrectomy","Analgesic Efficacy of Ultrasound-Guided Serratus Intercostal Plane Block Versus Erector Spinae Plane Block for Postoperative Pain Control After Open Nephrectomy: A Prospective Randomized Controlled Trial","Inclusion Criteria:\n\n1. Patients scheduled for elective open nephrectomy under general anesthesia via flank incision .\n2. Adult patients aged 18-65 years.\n3. Patients with an American Society of Anesthesiologists (ASA) physical status I to III.\n\nExclusion Criteria:\n\n1. Patient refusal.\n2. Allergy to local anesthetics and patient with infection at the injection site of block.\n3. Coagulation disorders or ongoing anticoagulant therapy.\n4. Patients receiving opioids for chronic analgesic therapy (cancer, addiction).\n5. Cognitive impairment preventing pain scoring.\n6. Neurological or psychiatric disorders affecting pain assessment.",{"count":54,"type":21},132,[24],"Effective postoperative pain management following open nephrectomy remains a significant clinical challenge.\n\nInadequate pain control after this procedure may lead to impaired respiratory function, delayed mobilization, prolonged hospital stay, increased opioid consumption, and a higher incidence of postoperative complications. Therefore, optimizing postoperative analgesia while minimizing opioid-related adverse effects is a key objective in perioperative care for patients undergoing open nephrectomy Traditionally, postoperative pain following open nephrectomy has been managed using systemic opioids, epidural analgesia, or paravertebral blocks.\n\nUltrasound-guided fascial plane blocks have emerged as valuable alternatives in modern regional anesthesia due to their simplicity, safety profile, and effectiveness. Among these techniques, the erector spinae plane (ESP) block has gained widespread popularity.\n\nThis block has been shown to provide effective analgesia for thoracic, abdominal, and urologic surgeries, including nephrectomy The ultrasound-guided serratus intercostal plane block (SIPB) is a more recently described regional anesthetic technique targeting the lateral cutaneous branches of the intercostal nerves by injecting local anesthetic between the serratus anterior muscle and the intercostal muscles or ribs By blocking these nerves, SIPB provides analgesia to the lateral thoracic wall and upper abdominal regions, which are particularly relevant to flank incisions used in open nephrectomy.\n\nPatients will be randomly allocated into two equal groups. Patients in group (S) will receive serratus intercostal plane block and those in group (E) will receive Erector spinae plane block . Both of these blocks will be performed after induction of general anaesthesia by an experienced anaesthesiologist The aim of this study is to to compare the analgesic efficacy of ultrasound-guided serratus intercostal plane block and erector spinae plane block in patients undergoing open nephrectomy.",[58,59],"Post Operative Pain","Open Nephrectomy",[61,62,63],"serratus intercostal plane block","Erector spinae plane block","open nephrectomy","2026-04-22",{"date":66,"type":37},"2026-04-29",{"date":68,"type":37},"2026-04-10",{"date":70,"type":21},"2027-06-01",{"name":43,"class":44},{"id":73,"slug":74,"hasResults":11,"nctId":75,"briefTitle":76,"officialTitle":77,"acronym":4,"eligibilityCriteria":78,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":79,"targetDuration":4,"studyType":22,"phases":81,"briefSummary":82,"conditions":83,"keywords":86,"overallStatus":91,"whyStopped":4,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":95,"completionDateStruct":96,"leadSponsor":98,"locationsCount":45},"100631985","low-versus-standard-volume-exora-block-in-laparoscopic-cholecystectomy-100631985","NCT07507799","Low Versus Standard Volume EXORA Block in Laparoscopic Cholecystectomy","Analgesic Efficacy of Low-Volume Versus Standard-Volume 0.25% Bupivacaine for Ultrasound-Guided External Oblique and Rectus Abdominis Plane Block in Laparoscopic Cholecystectomy, A Randomized Non-Inferiority Trial","Inclusion Criteria:\n\n* American Society of Anesthesiologists (ASA) physical status I or II.\n* Scheduled for elective laparoscopic cholecystectomy under general anesthesia.\n\nExclusion Criteria:\n\n* • Patient refusal to participate.\n\n  * Obese patients with a body mass index of more than 35 kg\u002Fm2.\n  * Known cognitive impairment or use of psychiatric drugs\n  * Known allergy to local anesthetics\n  * Infection at the needle insertion site.\n  * Coagulopathy, or bleeding disorders.\n  * Pregnancy\n  * History of chronic pain or chronic opioid use.\n  * Previous major upper abdominal surgery (which alters the fascial planes and anatomy).\n\nCriteria for Withdrawal from Study Analysis (Drop-outs):\n\n* Conversion to open cholecystectomy during surgery.\n* Failed EXORA block",{"count":80,"type":21},96,[24],"The original EXORA block used high local anesthetic volume (50 mL total), raising concerns about local anesthetic systemic toxicity (LAST). In such a bilaterally administered regional technique, evaluating the efficacy of a reduced-volume approach is warranted to maximize patient safety.",[84,85],"Pain, Postoperative","Post Operative Analgesia",[87,88,89,90],"EXORA","analgesic efficacy","low volume","laparoscopic cholecystectomy","NOT_YET_RECRUITING","2026-04-13",{"date":94,"type":37},"2026-04-16",{"date":68,"type":21},{"date":97,"type":21},"2026-11-02",{"name":43,"class":44},{"id":100,"slug":101,"hasResults":11,"nctId":102,"briefTitle":103,"officialTitle":104,"acronym":105,"eligibilityCriteria":106,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":107,"enrollmentInfo":108,"targetDuration":4,"studyType":110,"phases":4,"briefSummary":111,"conditions":112,"keywords":114,"overallStatus":91,"whyStopped":4,"lastUpdateSubmitDate":118,"lastUpdatePostDateStruct":119,"startDateStruct":121,"completionDateStruct":123,"leadSponsor":125,"locationsCount":45},"100626456","analgesia-nociception-index-monitoring-in-trigeminal-cardiac-reflex-during-nasal-septoplasty-100626456","NCT07435870","Analgesia Nociception Index Monitoring in Trigeminal Cardiac Reflex During Nasal Septoplasty","Utility of Analgesia Nociception Index (ANI) Monitoring in Predicting and Preventing Trigeminal Cardiac Reflex During Nasal Septoplasty","ANI","Inclusion Criteria:\n\n* Age 18-60 years.\n* American society of anesthesiologist physical status I-II\n* Indicated for primary septoplasty.\n\nExclusion Criteria:\n\n* Known cardiac arrhythmias or conduction disorders.\n* Use of beta-blockers or antiarrhythmic medications.\n* Previous nasal surgery and Combined nasal procedures.\n* Inability to obtain reliable Analgesia Nociception Index readings.","60 Years",{"count":109,"type":21},90,"OBSERVATIONAL","This study aims to evaluate the utility of Analgesia Nociception Index (ANI) monitoring as a predictive and preventive tool for TCR during septoplasty. By comparing standard anesthetic monitoring with ANI-guided analgesia, this research seeks to determine whether maintaining optimal autonomic balance can reduce the incidence of trigeminal cardiac reflex (TCR) and improve intraoperative cardiovascular stability.",[113],"ENT Disease",[115,116,117],"Analgesia Nociception Index","Trigeminal Cardiac Reflex","Septoplasty","2026-03-02",{"date":120,"type":37},"2026-03-04",{"date":122,"type":21},"2026-04-01",{"date":124,"type":21},"2027-05-01",{"name":43,"class":44},{"id":127,"slug":128,"hasResults":11,"nctId":129,"briefTitle":130,"officialTitle":131,"acronym":4,"eligibilityCriteria":132,"healthyVolunteers":11,"sex":16,"minAge":133,"maxAge":134,"enrollmentInfo":135,"targetDuration":4,"studyType":22,"phases":137,"briefSummary":138,"conditions":139,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":143,"lastUpdatePostDateStruct":144,"startDateStruct":146,"completionDateStruct":148,"leadSponsor":150,"locationsCount":45},"100626983","sacral-espb-vs-peng-block-for-hip-hemiarthroplasty-analgesia-100626983","NCT07442721","Sacral ESPB vs. PENG Block for Hip Hemiarthroplasty Analgesia","Sacral Erector Spinae Plane Block Versus Pericapsular Nerve Group Block For Analgesia In Hip Hemi Arthroplasty: A Randomized Comparative Study","Inclusion Criteria:\n\n* Patients with ages from 50 to 90 years of either gender, with diagnosis of intracapsular neck of femur fracture scheduled for elective hip hemiarthroplasty • Patients with an American Society of Anesthesiologists (ASA) physical status I to III.\n\nExclusion Criteria:\n\n* • Patient refusal.\n\n  * Allergy to local anesthetics and patient with infection at the injection site of block\n  * Patient with contraindication to spinal anesthesia.\n  * Coagulopathy as INR≥1.5 or platelets ≤80\\*103 \u002F microliter)\n  * Patients with body mass index\\>35 kg \u002F m2\n  * Patients with peripheral neuropathy or diabetic neuropathy\n  * Patients receiving opioids for chronic analgesic therapy (cancer, addiction).\n  * Cognitive impairment preventing pain scoring.\n  * Chronic renal failure requiring dose modification.\n  * Bilateral hip fracture or previous ipsilateral hip surgery","50 Years","90 Years",{"count":136,"type":21},80,[24],"Sacral erector spinae plane block(S-ESPB) has been recently described. Case reports are showing that it is useful in various types of surgery. In case presentations, it has been reported as effective in providing analgesia in the posterior branches of the sacral nerves in pilonidal sinus surgery, in the treatment of radicular pain at the L5 - S1 level, after a sex reassignment operation and hypospadias surgery, and its use in combination with lumbar ESPB for analgesia was reported after hip prosthesis surgery . Described in 2018, pericapsular nerve group (PENG) block selectively targets the articular branches of the femoral and accessory obturator nerves thereby providing potential motorsparing analgesia for hip surgery\n\n. Recent studies found that PENG block targets the articular branches of the femoral and accessory obturator nerves, only anesthetizes the anterior hip joint sparing posterior part , as well as there was a motor impairment after block which is from local anesthetic (LA) diffusion to the femoral nerve\n\n. Motor-sparing regional anesthesia techniques have emerged as a safer alternative, balancing effective pain relief with the preservation of quadriceps function . These techniques align with Enhanced Recovery After Surgery (ERAS) protocols, which emphasize multimodal pain control, opioid minimization, and early mobility to reduce complications such as venous thromboembolism (VTE) and postoperative pneumonia\n\n.",[140,141,142,27],"Hip Arthroplasty","Hip Fracture Surgeries","Femoral Neck Fractures","2026-02-28",{"date":145,"type":37},"2026-03-03",{"date":147,"type":37},"2026-02-01",{"date":149,"type":21},"2027-08-01",{"name":43,"class":44},{"id":152,"slug":153,"hasResults":11,"nctId":154,"briefTitle":155,"officialTitle":156,"acronym":4,"eligibilityCriteria":157,"healthyVolunteers":11,"sex":16,"minAge":158,"maxAge":159,"enrollmentInfo":160,"targetDuration":4,"studyType":22,"phases":162,"briefSummary":163,"conditions":164,"keywords":166,"overallStatus":91,"whyStopped":4,"lastUpdateSubmitDate":168,"lastUpdatePostDateStruct":169,"startDateStruct":171,"completionDateStruct":173,"leadSponsor":175,"locationsCount":4},"100618844","adductor-canal-block-and-ipack-block-vs-adductor-canal-block-and-the-gastrosoleus-interfascial-block-after-total-knee-arthroplasty-100618844","NCT07336901","Adductor Canal Block and IPACK Block vs Adductor Canal Block and the Gastrosoleus Interfascial Block After Total Knee Arthroplasty","Comparison of Adductor Canal Block and IPACK Block Versus Adductor Canal Block and the Gastrosoleus Interfascial Plane Block for Postoperative Analgesia After Total Knee Arthroplasty: a Prospective Double Blinded Study","Inclusion Criteria:\n\n* Patients of ASA class I to III of both sexes\n* undergoing unilateral total knee arthroplasty\n* 40-80 years old\n\nExclusion Criteria:\n\n* Patient refusal\n* History of coagulopathies\n* Severe renal insufficiency\n* Preexisting lower limb neurological abnormality\n* Known allergic history to any of the drugs used in this study","40 Years","80 Years",{"count":161,"type":21},86,[24],"Evaluate analgesic efficacy of adductor canal block with IPACK versus that of adductor canal block with gastrosoleus interfascial plane block in total knee arthroplasty surgeries.",[165],"Pain After Knee Arthroplasty",[167],"gastrosoleus interfascial plane block, knee arthroplasty","2026-01-07",{"date":170,"type":37},"2026-01-13",{"date":172,"type":21},"2026-02",{"date":174,"type":21},"2026-10",{"name":43,"class":44},{"id":177,"slug":178,"hasResults":11,"nctId":179,"briefTitle":180,"officialTitle":181,"acronym":4,"eligibilityCriteria":182,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":183,"targetDuration":4,"studyType":22,"phases":185,"briefSummary":187,"conditions":188,"keywords":191,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":196,"lastUpdatePostDateStruct":197,"startDateStruct":199,"completionDateStruct":201,"leadSponsor":203,"locationsCount":45},"100608761","phase-4-adding-lidocaine-to-custodiol-mixture-100608761","NCT07205757","Adding Lidocaine to Custodiol Mixture","Adding Lidocaine to Custodiol® Cardioplegia to Decrease Post-bypass Ventricular Arrhythmias in Adult Patients Undergoing Coronary Artery Bypass Grafting (CABG) Surgery; A Prospective Randomized Double-Blinded Clinical Trial.","Inclusion Criteria:\n\n* patients scheduled for elective Coronary artery bypass grafting surgery\n\nExclusion Criteria:\n\n* Emergency or Redo surgery.\n* Baseline rhythm other than sinus rhythm\n* Any degree of heart block, bundle branch block or hemiblock\n* Known allergy to lidocaine.\n* Chronic kidney disease.\n* Hepatic impairment.\n* Severe psychiatric illness.",{"count":184,"type":21},70,[186],"PHASE4","The Bretschneider solution, also known as Custodiol, has been widely used in open-heart surgery requiring cardiopulmonary bypass (CPB) since its introduction in 1970. Custodiol is widely favored by cardiac surgeons, being administered as a single dose, and is supposed to offer myocardial protection for up to three hours, permitting an uninterrupted surgical time, especially for intricate procedures The literature continues to debate the superiority of custodial and other cardioplegic solutions, such as the Del Nido and St. Thomas solutions, regarding both short-term and long-term outcomes. Clinical trials and daily practice showed that the use of custodial cardioplegic solution is associated with increased incidences of ventricular arrhythmias, and subsequently, the use of a defibrillator after Aortic Cross Clamp (ACC) removal at the end of CPB when compared to other types of cardioplegia solutions .One of the reasons for this difference mentioned in the literature is the lidocaine contained in other types of cardioplegic solutions. Lidocaine acts as a membrane stabilizer by blocking rapid sodium channels in the heart, thus preventing arrhythmias, in addition to its ability to inhibit calcium influx, which is the primary cause of ischemic-reperfusion injury.\n\nBased on these data, the investigators hypothesize that the increased incidence of Ventricular arrhythmias with the use of Custodiol compared to other solutions, such as St Thomas and Del Nido, may be attributed to the absence of lidocaine. Although Custodiol contains tryptophan as a membrane-stabilizing component, it may be beneficial to add lidocaine to the Custodiol mixture to decrease the incidence of VF after cross-clamp removal in adult patients undergoing elective CABG.",[189,190],"CAD","Arrhythmia Ventricular",[192,193,194,195],"Custodiol","lidocaine","Bretschneider solution","Ventricular arrythmia","2025-11-14",{"date":198,"type":37},"2025-11-17",{"date":200,"type":37},"2025-10-03",{"date":202,"type":21},"2026-06-01",{"name":43,"class":44},{"id":205,"slug":206,"hasResults":11,"nctId":207,"briefTitle":208,"officialTitle":209,"acronym":4,"eligibilityCriteria":210,"healthyVolunteers":211,"sex":16,"minAge":17,"maxAge":133,"enrollmentInfo":212,"targetDuration":4,"studyType":22,"phases":214,"briefSummary":215,"conditions":216,"keywords":219,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":223,"lastUpdatePostDateStruct":224,"startDateStruct":226,"completionDateStruct":228,"leadSponsor":230,"locationsCount":45},"100582745","dexmedetomidine-and-agitation-after-nasal-surgery-100582745","NCT06867302","Dexmedetomidine and Agitation After Nasal Surgery","Effectiveness of Single Bolus Versus Continuous Infusion of Dexmedetomidine in Mitigating Agitation in Adults Undergoing Nasal Surgery: a Prospective Randomized Trial","Inclusion Criteria:\n\n* American Society of Anesthesiologist (ASA) Ⅰ or II\n* Adults with body mass index (BMI) \\\u003C 30 Kg\u002Fm\n* Underwent elective nasal surgery.\n\nExclusion Criteria:\n\n* Significant comorbidity like hepatic, renal, or cardiac disease\n* Auditory impairment\n* Cognitive dysfunction\n* Substance abuse\n* Allergy to the studied medicines\n* Planned intensive care admission after the surgery.",true,{"count":213,"type":21},50,[24],"The main objective of study is to compare dexmedetomidine single bolus dose before extubation with continuous infusion as regards their efficacy in mitigating the incidence of emergence agitation in obese adults undergoing nasal surgery.",[217,218],"Nasal Disease","Agitation, Emergence",[220,221,222],"Dexmedetomidine","Emergence agitation","Nasal surgery","2025-03-05",{"date":225,"type":37},"2025-03-10",{"date":227,"type":37},"2025-03-01",{"date":229,"type":21},"2025-10-01",{"name":43,"class":44},{"id":232,"slug":233,"hasResults":11,"nctId":234,"briefTitle":235,"officialTitle":236,"acronym":4,"eligibilityCriteria":237,"healthyVolunteers":11,"sex":16,"minAge":133,"maxAge":134,"enrollmentInfo":238,"targetDuration":4,"studyType":22,"phases":240,"briefSummary":241,"conditions":242,"keywords":243,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":246,"lastUpdatePostDateStruct":247,"startDateStruct":249,"completionDateStruct":251,"leadSponsor":253,"locationsCount":45},"100568160","peng-block-in-comparison-with-anesthetic-infiltration-pai-after-hip-hemiarthroplasty-100568160","NCT06677606","PENG Block in Comparison With Anesthetic Infiltration (PAI) After Hip Hemiarthroplasty","The Analgesic Efficacy of Pericapsular Nerve Group Block (PENG) in Comparison With Periarticular Local Anesthetic Infiltration (PAI) Undergoing Hip Hemiarthroplasty : a Randomized Controlled Study","Inclusion Criteria:\n\nages from 50 to 90 years and undergoing bipolar hemiarthroplasty in Fayoum university hospital American Society of Anesthesiologists (ASA) physical status I to III,.\n\nExclusion Criteria:\n\nPatient refusal. contraindication to spinal anesthesia . clinically significant coagulopathy. infection at the injection site. allergy to local anesthetics. body mass index\\>35 kg m2., diabetic or other neuropathies. patients receiving opioids for chronic analgesic therapy.\n\n\\-",{"count":239,"type":21},54,[24],"The goal of this intervention study is to compare the analgesic efficacy of pericapsular nerve group (PENG) block versus periarticular anesthetic infiltration (PAI) block in patients undergo hemiarthroplasty after spinal anesthesia .\n\nThe main questions it aims to answer are:\n\nwhich block has more analgesic efficacy. which block has more motor-sparing analgesia.\n\nResearchers will compare optimal motor-sparing analgesia between PENG block and PAI after hemiarthroplasty.\n\nParticipants will be divided in two groups :\n\ngroup receive PENG block and other group receive PAI",[58],[244,245],"PENG bock","PAI block","2025-02-19",{"date":248,"type":37},"2025-02-20",{"date":250,"type":37},"2024-11-01",{"date":252,"type":21},"2025-10-31",{"name":43,"class":44},{"id":255,"slug":256,"hasResults":11,"nctId":257,"briefTitle":258,"officialTitle":259,"acronym":4,"eligibilityCriteria":260,"healthyVolunteers":211,"sex":261,"minAge":17,"maxAge":4,"enrollmentInfo":262,"targetDuration":4,"studyType":22,"phases":264,"briefSummary":265,"conditions":266,"keywords":267,"overallStatus":91,"whyStopped":4,"lastUpdateSubmitDate":270,"lastUpdatePostDateStruct":271,"startDateStruct":273,"completionDateStruct":275,"leadSponsor":277,"locationsCount":45},"100576134","rhomboid-intercostal-block-compared-with-thoracic-paravertebral-block-in-breast-cancer-surgeries-100576134","NCT06781346","Rhomboid Intercostal Block Compared With Thoracic Paravertebral Block in Breast Cancer Surgeries","Analgesic Efficacy of Rhomboid Intercostal Block Compared With Thoracic Paravertebral Block in Adult Patients Undergoing Breast Cancer Surgeries: A Randomized Controlled Double-blinded Study","Inclusion Criteria:\n\n* Patients 18 years of age or older .\n* American Society of Anesthesiologists (ASA) II-lll Scheduled for elective breast surgery for modified radical mastectomy, simple mastectomy, breast conservative surgery.\n\nExclusion Criteria:\n\n* Patient refusal.\n* Significant renal, hepatic and cardiovascular diseases.\n* History of allergy to one of the study drugs.\n* Any contraindication to regional anesthesia such as local infection or bleeding disorders.\n* Chronic opioid use, history of chronic pain and cognitive disorders.\n* Emergent surgeries","FEMALE",{"count":263,"type":21},180,[24],"Postoperative pain is a significant problem following breast surgery . If not treated in time, it may lead to delayed wound healing, respiratory depression, hemodynamic disorders, anxiety,other complications, and finally lead to difficult recovery of patients . Therefore, the prevention of postoperative pain is of great importance for patients.\n\nOpioids, while effective in pain management, are linked to a spectrum of adverse effects, including respiratory depression, post-operative nausea and vomiting, pruritus and constipation. The adoption of multimodal analgesia following breast cancer surgery emerges as a pivotal strategy to mitigate the complications associated with opioid use in the postoperative period.\\[4\\] US-guided rhomboid intercostal block (US-RIB) is a new fascial block technique discovered by Elsharkawy et al in 2016.\n\nInjection of local anaesthetic into the fascial plane between rhomboid major and intercostal muscles provided analgesia for both the anterior and posterior hemithorax,targets the lateral cutaneous branches of the ventral rami of the thoracic intercostal nerves from T2 to T9.\n\nSome clinical studies have reported that RIB can effectively reduce postoperative pain, reduce opioid consumption and improve the quality of recovery in patients with breast cancer surgeries .\n\nThe ultrasound guided Thoracic paravertebral (TPV) block in the context of breast cancer surgery has been reported to decrease postoperative pain score up to 72 hours, reduce opioid consumption, improve the quality of recovery, and suppress the development or decrease the severity of chronic pain by anesthetizing the spinal nerves as they emerge from the intervertebral foramina, producing ipsilateral somatosensory, visceral and sympathetic nerve blockade. TPV block involves the injection of local anesthetic (LA) into the wedge-shaped paravertebral space deep to the superior costotransverse ligament (SCTL).\n\nIn our study investigators hypothesized that the Rhomboid Intercostal block (RIB) can provide an effective analgesia comparable with thoracic paravertebral (TPV) block without the necessity to approach the pleura and the attendant risks in adult patients undergoing Breast cancer surgeries.",[84],[268,269],"Rhomboid Intercostal block","Breast surgery","2025-01-13",{"date":272,"type":37},"2025-01-17",{"date":274,"type":21},"2025-02-15",{"date":276,"type":21},"2025-12-15",{"name":43,"class":44},""]