[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Federal Research and Clinical Centre of Intensive Care Medicine and Rehabilitology\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":131},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,45,78,105],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":28,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100529986","comparing-fluid-responsiveness-assessment-methods-in-patients-with-impaired-consciousness-100529986",false,"NCT06180902","Comparing Fluid Responsiveness Assessment Methods in Patients With Impaired Consciousness","Comparing Fluid Responsiveness Assessment Methods in Patients With Impaired Consciousness: A Comprehensive Crossover Study Examination","Inclusion Criteria:\n\n* Age ≥ 18 years.\n* Hospitalization in an intensive care unit\n* Level of consciousness on the FOUR scale ≤ 12 points\n* Planned infusion therapy\n* Presence of a central venous catheter or direct indication for catheterization\n* The decision of the medical council to include the patient in the study\n\nExclusion Criteria:\n\n* Pulmonary edema\n* Absence of one or both lower extremities\n* Chronic kidney disease according to KDIGO classification ≥ stage 3b\n* Acute kidney injury grade 3\n* Documented or suspected increased intracranial pressure (cerebral edema, brain compression, hydrocephalus, etc.).\n* Presence of mitral valve regurgitation \\> grade 1\n* Presence of aortic valve regurgitation \\> grade 1\n* Patients previously enrolled in the \"COMPASS\" study in the period of 12 preceding hours","ALL","18 Years",{"count":19,"type":20},222,"ESTIMATED","INTERVENTIONAL",[23],"NA","Hypotension is a significant precursor to unfavorable clinical outcomes. To determine whether infusion therapy can positively impact the management of hypotension, several evaluative tests can be utilized. These include assessing the collapsibility and distensibility indices of the inferior vena cava, conducting a passive leg raising (PLR) test, and performing a fluid challenge (FC).\n\nTechnologically advanced methods leveraging dynamic testing are capable of real-time prediction of a patient's response to infusion therapy. Nonetheless, the use of systolic pressure variability (SPV), pulse pressure variability (PPV), and stroke volume variability (SVV) is often limited by the prohibitive costs of the necessary equipment. In contrast, the PLR test and FC are not subject to this limitation.\n\nDespite being deemed unreliable by numerous clinical protocols, static measurements of central venous pressure (CVP) or pulmonary capillary wedge pressure (PCWP) persist in usage among certain traditionalists within the medical community. It must be noted that the patient's baseline state and the unique clinical context are pivotal in determining the precision of these methodologies. For example, the PLR test may yield limited information in fully conscious patients, and the prognostic value of CVP measurements is significantly diminished in cases of pneumothorax and hydrothorax.\n\nRegrettably, there is a paucity of data on the prognostic utility of these tests in patients with altered levels of consciousness, despite their growing presence in intensive care units. This gap underscores the necessity for comprehensive studies that evaluate the predictive efficacy of infusion therapy responsiveness in patients with concurrent hypotension and impaired consciousness.\n\nPurpose of the study: to investigate the sensitivity and specificity of methods for assessing fluid responsiveness in patients with hypotension and decreased level of consciousness.",[26,27],"Hypotension","Cognitive Impairment",[26,27,29,30,31],"Fluid Responsiveness","Intensive Care","Fluid Infusion","RECRUITING","2026-01-22",{"date":35,"type":36},"2026-01-23","ACTUAL",{"date":38,"type":36},"2024-01-16",{"date":40,"type":20},"2026-05-20",{"name":42,"class":43},"Federal Research and Clinical Centre of Intensive Care Medicine and Rehabilitology","OTHER",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":4,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":52,"targetDuration":4,"studyType":21,"phases":54,"briefSummary":56,"conditions":57,"keywords":64,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":44},"100598327","phase-4-continuous-vs-bolus-administration-of-nsaids-after-laparoscopic-surgery-for-multimodal-analgesia-100598327","NCT07070050","Continuous vs. Bolus Administration of NSAIDs After Laparoscopic Surgery for Multimodal Analgesia","Continuous vs. Bolus Administration of NSAIDs After Laparoscopic Surgery for Multimodal Analgesia: Pilot Randomized Controlled Trial","Inclusion Criteria:\n\n* Age \\> 18 years old\n* Elective laparoscopic surgery\n* General anesthesia\n* Signed informed consent from the patient to participate in the study\n* RASS scale from -2 to +1 on admission to a surgical department or ICU\n\nExclusion Criteria:\n\n* History of ibuprofen allergy\n* Active erosive or ulcerative lesions of the gastrointestinal tract\n* Chronic use of opioid analgesics or NSAIDs prior to enrollment\n* Chronic kidney disease ≥ 3b stage according to the KDIGO classification\n* Liver dysfunction (three times exceeding the upper reference limit of ALT or AST)\n* A history of bronchial asthma\n* A history of hereditary coagulopathies\n* A history of use of anticoagulants",{"count":53,"type":20},100,[55],"PHASE4","Currently the prevalent approach to perioperative management of patients is ERAS (Enhanced Recovery After Surgery) concept. This approach includes numerous aspects, among which the perioperative use of multimodal analgesia takes one of the leading places. Within the ERAS guidelines all sorts of minimization of opioid analgesics use in schemes of postoperative analgesia are appreciated. Thus, new pharmacological approaches are being actively developed currently in order to achieve adequate analgesia and to minimize the use of this group of drugs.\n\nOne of the most perspective trends within the multimodal analgesia concept is continuous infusion of non-steroidal anti-inflammatory drugs (NSAID). Up to date there are papers that both confirm the effectiveness of this method for maintaining adequate postoperative analgesia and show its limitations and deny the advantages of the continuous use of NSAID.\n\nUp to this time the main attention of the medical community was paid for such drugs as paracetamol and ketoprofen. Nevertheless, one of the most common and safe NSAID is ibuprofen. In spite of this, there are no studies that explore the effectiveness of the continuous infusion of this drug. Thus, the lack of even low-quality evidence led to setting up a study of effectiveness and safety of continuous infusion of ibuprofen in comparison to its bolus injection.",[58,59,60,61,62,63],"Analgesic Drugs","Analgesic, Nonopioid","Analgesic Efficacy","Analgetic Consumption","Postoperative Care","Pain Management",[65,66,67,68,69],"NSAID","pain management","analgesia","postoperative care","analgesic drug","2025-07-07",{"date":72,"type":36},"2025-07-17",{"date":74,"type":36},"2025-05-05",{"date":76,"type":20},"2026-11-20",{"name":42,"class":43},{"id":79,"slug":80,"hasResults":11,"nctId":81,"briefTitle":82,"officialTitle":83,"acronym":4,"eligibilityCriteria":84,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":85,"targetDuration":4,"studyType":87,"phases":4,"briefSummary":88,"conditions":89,"keywords":95,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":44},"100558028","intraoperative-diagnosis-of-neurocognitive-complications-via-electroencephalographic-analysis-100558028","NCT06545786","Intraoperative Diagnosis of Neurocognitive Complications Via Electroencephalographic Analysis","Intraoperative Diagnosis of Neurocognitive Complications Via Electroencephalographic (IDEA Network)","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Scheduled non-cardiac surgery of intermediate or high risk\n* General anesthesia using inhalational anesthetics\n* Informed consent from the patient to participate in the study\n\nExclusion Criteria:\n\n* Preoperative MMSE score less than 20 points\n* History of any mental illness\n* Use of psychotropic drugs within 1 month prior to inclusion in the study\n* Presence of neuromuscular diseases\n* Neurosurgical procedures\n* Inability to undergo preoperative testing for any reason",{"count":86,"type":20},265,"OBSERVATIONAL","Postoperative neurocognitive disorders (PND) are serious and common complications after surgery, especially in elderly patients. These disorders can affect cognitive functions for years, deteriorating quality of life and increasing hospital stays and medical costs. Diagnosing PND is challenging due to their varied manifestations, such as memory and attention problems, and the lack of standardized criteria and biomarkers.\n\nOne well-studied form of PND is postoperative delirium (POD). According to the ICD-10, POD is an organic cerebral syndrome characterized by disturbances in consciousness, attention, perception, and other cognitive functions. Researchers suggest that POD development involves a combination of predisposing and precipitating factors.\n\nElectroencephalography (EEG) has been used in anesthesiology to assess anesthesia depth and intraoperative awareness. Modern EEG analysis methods, like spectral analysis, offer new ways to evaluate patients' neurophysiological states. Studies show that EEG monitoring can predict complications such as intraoperative stroke and delirium, particularly in cardiothoracic and neurosurgical operations.\n\nThe relationship between EEG patterns and POD is not well understood. Specific EEG patterns may indicate the risk of POD, aiding in the identification of risk factors and prevention methods. This could help anesthesiologists and surgeons optimize their approaches, reducing the risk of cognitive complications.",[90,91,92,93,94],"Surgery","Postoperative Delirium","Anesthesia","Silent Stroke","Emergence Delirium",[96,92,91,93,94],"Non-cardiac surgery","2025-04-04",{"date":99,"type":36},"2025-04-08",{"date":101,"type":36},"2024-09-25",{"date":103,"type":20},"2027-08-20",{"name":42,"class":43},{"id":106,"slug":107,"hasResults":11,"nctId":108,"briefTitle":109,"officialTitle":110,"acronym":4,"eligibilityCriteria":111,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":112,"targetDuration":4,"studyType":87,"phases":4,"briefSummary":114,"conditions":115,"keywords":118,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":123,"lastUpdatePostDateStruct":124,"startDateStruct":126,"completionDateStruct":128,"leadSponsor":130,"locationsCount":44},"100558032","renin-levels-as-prognostic-indicators-of-septic-shock-severity-and-outcome-100558032","NCT06545838","Renin Levels as Prognostic Indicators of Septic Shock Severity and Outcome","Renin Levels as Prognostic Indicators of Septic Shock Severity and Outcome: Prospective Cohort Study (SOS Trial)","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Hospitalization in the intensive care unit\n* Confirmed diagnosis of Sepsis within 24 hours\n* Signed informed consent or a decision by the medical council to include the patient in the study\n\nExclusion Criteria:\n\n* Any surgical intervention on the kidneys and\u002For adrenal glands performed within 28 days prior to the patient's inclusion in the study\n* Patients previously included in this study",{"count":113,"type":20},50,"The Surviving Sepsis Campaign (SSC) of 2021 characterizes sepsis as a life-threatening organ dysfunction caused by a dysregulated host response to infection, with a mortality rate of over 30%, which increases to 40% or more in the case of septic shock. Although concept of sepsis has improved, significant gaps remain in assessing its clinical severity and predicting patient outcomes.\n\nRecognized markers of the severity of septic shock are procalcitonin (PCT), presepsin, and, to a certain extent, lactate. Elevated lactate levels result from a shift to anaerobic glycolysis and indicate inadequate oxygen delivery to tissues. Despite the importance of procalcitonin in the course of sepsis, it has proven to be a suboptimal diagnostic biomarker for the development of sepsis, with sensitivity and specificity below 80%. As a result, the use of procalcitonin in addition to clinical assessment to determine the indications for initiating antibiotic therapy is not recommended. Meanwhile, presepsin, although a potential biomarker for the early diagnosis of sepsis, also has only moderate accuracy according to current data and cannot be used as the only test for the diagnosis of sepsis.\n\nRenin is a crucial enzyme in the renin-angiotensin-aldosterone system (RAAS), which plays an important role in the regulation of blood pressure, tissue perfusion, and the balance of water and electrolytes. Thus, renin may be the sensitive biomarker with good prognostic qualities in the context of sepsis and septic shock. Preliminary studies have indicated that elevated renin levels may act as an indicator of patient severity, and could also be used as a marker for the development of septic shock and mortality prognosis.\n\nThis study aims to address these gaps by investigating the role of renin as a biomarker for the severity of sepsis and septic shock, focusing on its potential for more accurate prediction of clinical outcomes.",[116,117],"Sepsis","Septic Shock",[116,119,120,121,122],"Septic shock","Renin","Lactate","Procalcitonin","2025-03-10",{"date":125,"type":36},"2025-03-12",{"date":127,"type":36},"2025-01-29",{"date":129,"type":20},"2027-07-20",{"name":42,"class":43},""]