[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Federal University of Health Science of Porto Alegre\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":252},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,9,0,[8,41,75,103,131,150,181,202,222],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":40},"100610844","analysis-of-the-effect-of-a-fine-manual-skills-intervention-in-a-specific-context-on-the-linguistic-processing-of-healthy-young-adults-100610844",false,"NCT07232862","Analysis Of The Effect Of A Fine Manual Skills Intervention In A Specific Context On The Linguistic Processing of Healthy Young Adults","Inclusion Criteria:\n\n* Right-handed young people between 19 and 24 years old;\n* Accept participation in the study and sign the free and informed consent form.\n\nExclusion Criteria:\n\n* Presence of previously diagnosed neurological and\u002For psychiatric disorders;\n* History of traumatic brain injuries;\n* Pregnant women or women suspected of being pregnant.",true,"ALL","19 Years","24 Years",{"count":20,"type":21},40,"ESTIMATED","INTERVENTIONAL",[24],"NA","This is a randomized, single-blind clinical trial that will include healthy individuals between the ages of 19 and 24. Participants with previously diagnosed neurological and\u002For psychiatric disorders, a history of traumatic brain injury, use of psychoactive substances or medications that may affect cognition, and pregnant women or women suspected of being pregnant will be excluded. The sample will be a convenience sample, with participants randomly allocated to intervention and control groups (1:1), and the sample size calculation will be based on a pilot study. Participants will be assessed at two different time points, before and after the intervention, for fine manual dexterity and syntactic language processing. The intervention group will undergo fine manual dexterity training in a specific context, while the control group will undergo an intervention with a less complex task and without a specific context. Both protocols will consist of 20-minute sessions, held five times a week over two weeks, in a synchronous online format, via the Google Meet videoconferencing platform.",[27],"Healthy Participants","RECRUITING","2026-04-08",{"date":31,"type":32},"2026-04-09","ACTUAL",{"date":34,"type":32},"2025-11-13",{"date":36,"type":21},"2026-12-31",{"name":38,"class":39},"Federal University of Health Science of Porto Alegre","OTHER",2,{"id":42,"slug":43,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":45,"acronym":4,"eligibilityCriteria":46,"healthyVolunteers":11,"sex":16,"minAge":47,"maxAge":4,"enrollmentInfo":48,"targetDuration":4,"studyType":22,"phases":50,"briefSummary":51,"conditions":52,"keywords":59,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":74},"100626167","prediction-of-infectious-agents-in-the-biofire-filmarray-biomrieux-meningitisencephalitis-panel-based-on-clinical-syndrome-and-cerebrospinal-fluid-parameters-a-diagnostic-stewardship-proposal-100626167","NCT07432113","Prediction of Infectious Agents in the Biofire® FilmArray bioMérieux Meningitis\u002FEncephalitis Panel Based on Clinical Syndrome and Cerebrospinal Fluid Parameters: a Diagnostic Stewardship Proposal.","Inclusion Criteria:\n\nPatients aged 18 years or older, of any gender.\n\nPresence of at least two of the following symptoms: fever, lethargy, altered level of consciousness, seizures, acute focal deficit, signs of meningeal irritation, or headache.\n\nSymptoms must have started within the last 30 days.\n\nObligatory presence of pleocytosis (CSF white blood cell count ≥ 5 cells\u002Fmm³).\n\nProvision of written Informed Consent (TCLE) by the patient or their legal representative.\n\nExclusion Criteria:\n\n* Failure to sign the Informed Consent Form.\n\nClinical manifestations lasting more than 30 days.\n\nPatients under 18 years of age.\n\nPatients who have undergone neurosurgery within 30 days prior to the onset of symptoms (applies to both prospective and control groups).","18 Years",{"count":49,"type":21},182,[24],"Background: Infections of the central nervous system (CNS) are associated with high morbidity, mortality, and high resource consumption. The BioFire FilmArray is a molecular diagnostic panel capable of identifying 14 pathogens in approximately one hour, including bacteria, viruses, and fungi. However, it is not yet widely available in the Brazilian public health system.\n\nObjective: The primary objective of this study is to evaluate the pre-test probability of positivity of the Biofire FilmArray bioMérieux Meningitis\u002FEncephalitis panel in patients with clinical syndrome of meningitis and\u002For encephalitis and pleocytosis (CSF ≥ 5 cells).\n\nAs secondary objectives, the study aims to:\n\nDetermine the clinical impact of using the panel through variables such as total hospital stay and length of stay in the intensive care unit.\n\nCompare the duration of antibiotic use in non-bacterial cases between groups. Compare the time to reduction of acyclovir use in etiologies without proven benefit.\n\nCompare the time for identification of the causative pathogen and mortality rates between the study groups.\n\nPerform a cost-effectiveness analysis of the test. Compare the request for imaging exams, such as brain MRI and CT scan, between the groups.\n\nMethods: This is a prospective, transversal, and multicenter study conducted at Santa Casa de Porto Alegre and Hospital Dom João Becker. Patients will be compared with a retrospective cohort used as a control group.",[53,54,55,56,57,58],"Meningitis","Encephalitic Infection","Encephalitis","Meningitis, Fungal","Meningitis, Viral","Meningitis, Bacterial",[60,61,62,63,64],"filmarray","biofire","biofire filmarray","meningits","encephalitis","NOT_YET_RECRUITING","2026-02-18",{"date":68,"type":32},"2026-02-25",{"date":70,"type":21},"2026-03-16",{"date":72,"type":21},"2029-10-31",{"name":38,"class":39},1,{"id":76,"slug":77,"hasResults":11,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":4,"eligibilityCriteria":81,"healthyVolunteers":15,"sex":16,"minAge":82,"maxAge":83,"enrollmentInfo":84,"targetDuration":4,"studyType":22,"phases":86,"briefSummary":87,"conditions":88,"keywords":90,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":74},"100515279","different-intervention-models-of-premature-infants-based-on-the-icf-biopsychosocial-model-100515279","NCT05989438","Different Intervention Models of Premature Infants Based on the ICF Biopsychosocial Model","Analysis of the Impact of Different Intervention Models on the Neuropsychomotor Development of Premature Infants Based on the ICF Biopsychosocial Model","Inclusion Criteria:\n\n* 1\\. Gestational age less than 37 weeks, corrected age between 4 and 12 months (one and a half month window) and at 24 months (four months window)\n* Babies from the High Risk Outpatient Clinic of the UCS Clinical Center, registered there;\n* Authorization of those responsible for the minor consenting to participation in the study by signing the Free and Informed Consent Form (TCLE).\n\nExclusion Criteria:\n\n* All those subjects who do not follow the items mentioned above;\n* Presenting neurological diseases;\n* Presence of acute diseases (eg pneumonia, bronchiolitis, trauma)\n* Musculoskeletal alterations;\n* Genetic syndromes;\n* In genetic investigation;\n* Heart diseases with indication for surgical intervention;\n* Untreated congenital torticollis;\n* Congenital clubfoot;\n* Cerebral hemorrhage grade IV\n* Those who do not undergo the first and\u002For last evaluation;\n* Incomplete evaluation;\n* Convulsive crisis during study period;\n* Participants from other intervention programs.","4 Months","2 Years",{"count":85,"type":21},60,[24],"Prematurity is an important risk factor for delayed neuropsychomotor development. The main objective of this study is to analyze the impact of different intervention models on the neuropsychomotor development of premature babies based on the ICF biopsychosocial model.",[89],"Prematurity",[89,91,92,93,94],"Physiotherapy","CIF","Child development","Early Intervention","2025-06-19",{"date":97,"type":32},"2025-06-25",{"date":99,"type":32},"2023-08-01",{"date":101,"type":21},"2026-01-11",{"name":38,"class":39},{"id":104,"slug":105,"hasResults":11,"nctId":106,"briefTitle":107,"officialTitle":107,"acronym":4,"eligibilityCriteria":108,"healthyVolunteers":11,"sex":16,"minAge":47,"maxAge":109,"enrollmentInfo":110,"targetDuration":4,"studyType":22,"phases":112,"briefSummary":113,"conditions":114,"keywords":117,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":123,"lastUpdatePostDateStruct":124,"startDateStruct":126,"completionDateStruct":128,"leadSponsor":130,"locationsCount":40},"100585694","effects-of-eccentric-training-in-the-rehabilitation-of-patients-undergoing-anterior-cruciate-ligament-reconstruction-a-randomized-controlled-trial-100585694","NCT06905691","Effects of Eccentric Training in the Rehabilitation of Patients Undergoing Anterior Cruciate Ligament Reconstruction: a Randomized Controlled Trial","Inclusion Criteria:\n\n\\- Individuals of both genders, aged between 18 and 40 years, scheduled for ACL reconstruction surgery during the data collection period.\n\nExclusion Criteria:\n\n* Delay of more than 7 days after surgery to initiate the rehabilitation program proposed by the study;\n* Presence of injuries related to the rupture of the ACL that hinder partial weight-bearing in the first week after surgery, either due to medical recommendation or the patient inability\u002Fdisposition.","40 Years",{"count":111,"type":21},34,[24],"This study aims to investigate the effects of eccentric training on the functional rehabilitation of patients undergoing Anterior Cruciate Ligament Reconstruction (ACL-R). Thirty-four participants undergoing ACL-R will be randomly assigned to two groups: the Conventional Training Group (CTG) and the Eccentric Training Group (ETG). Both groups will adhere to the same post-surgical rehabilitation program, commencing in the first week after ACL-R and continuing until the criteria for sports resumption are achieved. The rehabilitation program will be structured into four phases: immediate post-operative, preparatory, general acquisition, and specific acquisition. The key distinction between the groups lies in their exercise regimen: ETG will prioritize the eccentric phase of movement, whereas CTG will engage in conventional exercises, maintaining uniform load across both movement phases. Assessment procedures will be conducted at three intervals for all participants: immediately post-operative, at 12 weeks post-ACL-R surgery (before the initiation of the training protocol), and at 25 weeks post-ACL-R surgery (upon completion of the training protocol). The primary outcome measure will be the maximum isometric strength of knee extensors. Secondary outcomes will encompass functional status, maximum isometric strength of knee flexors, peak dynamic strength during leg press, quadriceps muscle atrophy, performance in jump tests, and psychological readiness.",[115,116],"Anterior Cruciate Ligament Reconstruction Rehabilitation","Anterior Cruciate Ligament Reconstruction",[118,91,119,120,121,122],"Knee","Quadriceps","Anterior cruciate ligament reconstruction","Eccentric Exercise","Eccentric","2025-04-22",{"date":125,"type":32},"2025-04-24",{"date":127,"type":32},"2025-03-01",{"date":129,"type":21},"2026-12",{"name":38,"class":39},{"id":132,"slug":133,"hasResults":11,"nctId":134,"briefTitle":135,"officialTitle":135,"acronym":4,"eligibilityCriteria":136,"healthyVolunteers":11,"sex":16,"minAge":47,"maxAge":109,"enrollmentInfo":137,"targetDuration":4,"studyType":22,"phases":138,"briefSummary":139,"conditions":140,"keywords":141,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":143,"lastUpdatePostDateStruct":144,"startDateStruct":146,"completionDateStruct":148,"leadSponsor":149,"locationsCount":40},"100536064","neuromuscular-electrical-stimulation-superimposed-or-not-on-voluntary-contraction-after-reconstruction-of-the-anterior-cruciate-ligament-a-randomized-controlled-trial-100536064","NCT06259968","Neuromuscular Electrical Stimulation Superimposed or Not on Voluntary Contraction After Reconstruction of the Anterior Cruciate Ligament: a Randomized Controlled Trial","Inclusion Criteria:\n\n\\- Individuals of both genders, aged between 18 and 40 years, scheduled for ACL reconstruction surgery during the data collection period.\n\nExclusion Criteria:\n\n* Failure to attend the pre-surgery assessment session;\n* Delay of more than 7 days after surgery to initiate the rehabilitation program proposed by the study;\n* Presence of injuries related to the rupture of the ACL that hinder partial weight-bearing in the first week after surgery, either due to medical recommendation or the patient inability\u002Fdisposition.",{"count":20,"type":21},[24],"This study aims to evaluate the effectiveness of neuromuscular electrical stimulation with superimposed voluntary contraction (NMES+ group) compared to NMES without voluntary contraction (NMES group) during the initial month of rehabilitation post anterior cruciate ligament reconstruction (ACLR). Forty patients will be randomly assigned to either the NMES group or the NMES+ group. Both groups will follow an identical rehabilitation regimen in the first month after surgery, which includes interventions for symptom management, inflammation control, edema reduction, improved joint motion range, and restoration of muscle function.\n\nAll participants will undergo identical assessment protocols at four time points: pre-surgery evaluation, and assessments at 2, 15, and 30 days post-ACLR. The primary outcome of the study is the maximal isometric strength of knee extensors. Secondary outcomes encompass thigh muscle atrophy, self-reported functional impairments, knee pain, knee edema, joint range of motion, and quadriceps activation status.",[115,116],[142,118,91,119,120],"Neuromuscular Electrical Stimulation","2025-03-31",{"date":145,"type":32},"2025-04-01",{"date":147,"type":32},"2024-05-01",{"date":36,"type":21},{"name":38,"class":39},{"id":151,"slug":152,"hasResults":11,"nctId":153,"briefTitle":154,"officialTitle":155,"acronym":4,"eligibilityCriteria":156,"healthyVolunteers":11,"sex":16,"minAge":47,"maxAge":4,"enrollmentInfo":157,"targetDuration":4,"studyType":22,"phases":159,"briefSummary":161,"conditions":162,"keywords":167,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":172,"lastUpdatePostDateStruct":173,"startDateStruct":175,"completionDateStruct":177,"leadSponsor":179,"locationsCount":180},"100501836","phase-3-efficacy-and-safety-of-high-dose-liposomal-amphotericin-b-for-disseminated-histoplasmosis-in-aids-100501836","NCT05814432","Efficacy and Safety of High-dose Liposomal Amphotericin B for Disseminated Histoplasmosis in AIDS","Efficacy and Safety of High-dose Liposomal Amphotericin B (10 Mg\u002Fkg) for Disseminated Histoplasmosis in AIDS: a Randomized Phase III Trial (INDUCTION Trial)","Inclusion Criteria:\n\n* Adult patients admitted to the centers that will be part of the study\n* Infected by the HIV, regardless of the use of antiretroviral therapy\n* Patients diagnosed with disseminated histoplasmosis, confirmed by classical mycological methods (microscopy, culture or histopathology) or urinary Histoplasma antigen detection\n* Patients with central nervous system (CNS) infection may be included if they have an alternative diagnosis suggestive of another CNS infection\n* Patients using fluconazole for oroesophageal candidiasis may be included\n\nExclusion criteria:\n\n* Refusal to participate in the trial\n* Previous diagnosis of histoplasmosis\n* Pregnant or lactating women\n* Patients with renal failure at any given time (serum creatinine \\> 2x or upper limit of normality (KDIGO, 2012)\n* Previous severe reaction to a polyene antifungal\n* Receipt of more than one dose of a polyene antifungal in the last 48 h\n* Suspected histoplasmosis involving the central nervous system\n* Patients who, in the judgment of the attending physician, have the prospect of death within the next 48 hours after selection, will also be excluded\n* Patients with suspected histoplasmosis involving the central nervous system (CNS), as this condition requires high doses of amphotericin B\n* Patients with the prospect of death in the next 48 hours after selection\n* Patients with a concomitant diagnosis of cryptococcus will be excluded, as will patients with leishmaniasis in treatment or in secondary prophylaxis with amphotericin\n* Patients without the capacity to administer enteral medication-at the discretion of the principal investigator of each center-considering that these patients will not be able to use itraconazole orally or through a feeding tube",{"count":158,"type":21},279,[160],"PHASE3","Phase III trial evaluating the safety and efficacy of a single high dose (10 mg\u002Fkg) of liposomal amphotericin B for disseminated histoplasmosis in AIDS patients, in comparison to standard therapy (3 mg\u002Fkg of liposomal amphotericin B for two weeks) (INDUCTION trial).",[163,164,165,166],"Disseminated Histoplasma Capsulatum Infection","AIDS and Infections","Immunosuppression","Fungal Infection",[168,169,170,171],"Disseminated Histoplasmosis","AIDS","Liposomal amphotericin B","Fungal infection","2025-01-31",{"date":174,"type":32},"2025-02-04",{"date":176,"type":32},"2025-01-16",{"date":178,"type":21},"2026-11-28",{"name":38,"class":39},5,{"id":182,"slug":183,"hasResults":11,"nctId":184,"briefTitle":185,"officialTitle":185,"acronym":4,"eligibilityCriteria":186,"healthyVolunteers":11,"sex":16,"minAge":47,"maxAge":187,"enrollmentInfo":188,"targetDuration":4,"studyType":22,"phases":190,"briefSummary":191,"conditions":192,"keywords":4,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":194,"lastUpdatePostDateStruct":195,"startDateStruct":197,"completionDateStruct":199,"leadSponsor":201,"locationsCount":4},"100574644","chronic-effect-of-whole-body-electrical-stimulation-in-copd-patients-100574644","NCT06761963","Chronic Effect of Whole-body Electrical Stimulation in COPD Patients","Inclusion Criteria:\n\n* Diagnosis of COPD GOLD 3 and 4;\n* Age between 18 and 80 years;\n* Ability to ambulate.\n\nExclusion Criteria:\n\n* Cognitive dysfunction that prevents assessments from being carried out, as well as inability to understand and sign the informed consent form (ICF);\n* Intolerance to the electrostimulator and\u002For change in skin sensitivity;\n* Patients with stroke sequelae;\n* Recent acute myocardial infarction (two months);\n* Uncontrolled hypertension;\n* New York Heart Association grade IV heart failure or decompensated;\n* Unstable angina or arrhythmia;\n* Peripheral vascular changes in lower limbs such as deep vein thrombosis;\n* Disabling osteoarticular or musculoskeletal disease;\n* Uncontrolled diabetes (glycemia \\> 300mg\u002FdL);\n* Patients with cancer and\u002For undergoing cancer treatment;\n* Patients with systemic lupus erythematosus or other autoimmune disease;\n* Artificial cardiac pacemaker;\n* Epilepsy;\n* Hemophilia;\n* Liver and kidney diseases.","80 Years",{"count":189,"type":21},16,[24],"Randomized clinical trial. Patients with chronic obstructive pulmonary disease (COPD) GOLD III or IV will undergo 16 sessions of Whole-body Electrical Stimulation (WB-EMS) or pulmonary rehabilitation (PR), twice a week. WB-EMS will be performed in association with squats, biceps and triceps exercises, climbing up and down a step, and abdominal exercises. There will be a progression in the number of muscle contractions after the fourth (from 64 to 96) and tenth sessions (96 to 120). PR will consist of upper and lower limb strengthening exercises. Both groups will perform aerobic exercise (essential component of the pulmonary rehabilitation program). Peripheral muscle strength (dynamometry), respiratory muscle strength (maximum inspiratory and expiratory pressure), muscle thickness (ultrasound), functional capacity (6MWT), quality of life (Saint George's Respiratory Questionnaire), inflammatory profile (PCR, IL-6 e IL-10, TNFα), oxidative stress (protein oxidation, superoxide dismutase and catalase, total hydrogen sulfides, dichlorofluorescein diacetate) will be assessed before and after the 16 sessions.",[193],"Chronic Obstructive Pulmonary Disease (COPD)","2025-01-06",{"date":196,"type":32},"2025-01-07",{"date":198,"type":21},"2025-01-20",{"date":200,"type":21},"2025-04-10",{"name":38,"class":39},{"id":203,"slug":204,"hasResults":11,"nctId":205,"briefTitle":206,"officialTitle":207,"acronym":4,"eligibilityCriteria":208,"healthyVolunteers":11,"sex":16,"minAge":47,"maxAge":187,"enrollmentInfo":209,"targetDuration":4,"studyType":22,"phases":211,"briefSummary":212,"conditions":213,"keywords":4,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":215,"lastUpdatePostDateStruct":216,"startDateStruct":218,"completionDateStruct":220,"leadSponsor":221,"locationsCount":4},"100554702","effects-of-whole-body-electrostimulation-on-patients-with-chronic-kidney-disease-100554702","NCT06502522","Effects of Whole-body Electrostimulation on Patients With Chronic Kidney Disease","Effects of Whole-body Electrostimulation on Kidney Function and Physical Capacity of Patients With Chronic Kidney Disease: Randomized Clinical Trial","Inclusion Criteria:\n\n* Patients diagnosed with CKD (≥ 3 months) in stages 3-4 (GFR between 59 and 15 ml\u002Fmin\u002F1.73m2);\n* Age between 18 and 80 years old;\n* Functional capacity ≥ 300 meters in the six-minute walk test.\n\nExclusion Criteria:\n\n* Cognitive dysfunction that prevents assessments from being carried out or inability to understand and sign the informed consent form;\n* Intolerance to electrical stimulator and\u002For changes in skin sensitivity;\n* Skin injuries or burns where the electrodes are positioned;\n* Patients with stroke sequelae;\n* Recent acute myocardial infarction (two months);\n* Uncontrolled hypertension (SBP\\>230 mmHg and DBP\\>120 mmHg);\n* New York Heart Association grade IV heart failure or decompensated;\n* Unstable angina or arrhythmia;\n* Artificial cardiac pacemaker or implantable cardioverter defibrillator;\n* Peripheral vascular changes in the lower limbs such as deep vein thrombosis;\n* Disabling osteoarticular or musculoskeletal disease;\n* Uncontrolled diabetes (glycemia \\> 300mg\u002FdL);\n* Patients with cancer and\u002For undergoing oncological treatment;\n* Epilepsy;\n* Hemophilia;\n* Chronic obstructive pulmonary disease;\n* Grade II obesity (BMI≥35).",{"count":210,"type":21},30,[24],"Chronic kidney disease (CKD) consists of kidney damage, with consequent progressive and irreversible loss of kidney function. In the early stages of the disease, a reduction in circulating levels of the α-klotho protein is already observed, which is related to worsening renal function. Therapeutic strategies that increase serum levels of α-klotho may be of great value in the treatment of CKD. Electrical stimulation contributes to the reduction of reactive oxygen species, DNA damage and improves the effectiveness rate of dialysis, suggesting a systemic effect in patients with terminal CKD. The objective of this study is to evaluate the effects of whole body electrical stimulation on renal function and physical capacity in patients with CKD not dependent on dialysis.",[214],"Renal Insufficiency, Chronic","2024-07-16",{"date":217,"type":32},"2024-07-18",{"date":219,"type":21},"2024-08-01",{"date":127,"type":21},{"name":38,"class":39},{"id":223,"slug":224,"hasResults":11,"nctId":225,"briefTitle":226,"officialTitle":226,"acronym":4,"eligibilityCriteria":227,"healthyVolunteers":11,"sex":228,"minAge":47,"maxAge":229,"enrollmentInfo":230,"targetDuration":4,"studyType":22,"phases":232,"briefSummary":233,"conditions":234,"keywords":238,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":244,"lastUpdatePostDateStruct":245,"startDateStruct":247,"completionDateStruct":249,"leadSponsor":251,"locationsCount":74},"100551463","effects-of-photobiomodulation-on-pain-and-sexual-function-in-women-with-dyspareunia-randomized-clinical-trial-100551463","NCT06460415","Effects of Photobiomodulation on Pain and Sexual Function in Women With Dyspareunia: Randomized Clinical Trial","Inclusion Criteria:\n\n* Women, aged between 18 and 45 years classified with dyspareunia criteria, according to the guidelines of the European Association of Urology guideline (2022)2, who report pain in relationship greater than 3 on the visual numeric pain scale at the beginning of participation in the research , who present sensitivity to unidigital palpation of the pelvic muscular wall (e.g., levator ani, coccygeus, obturator) and who report feeling pain during penetration for at least 6 months.\n\nExclusion Criteria:\n\n* Women with a history of neurological or oncological diseases or bone fractures in the pelvic region, in addition to radiculopathies, decompensated heart disease or metabolic disorders, pregnant women, lactating women, women in menopause, women with difficulties in understanding written or spoken language, in use of photosensitizing drugs, who present an inflammatory condition or have used anti-inflammatories on the day of the evaluation, red flags (post-coital bleeding, abrupt unexplained weight loss, presence of a mass visible on ultrasound, macroscopic or microscopic hematuria), who have a diagnosis of painful bladder syndrome, irritable bowel syndrome, interstitial cystitis, fibromyalgia. Who have a history of spine surgery or have undergone any surgical intervention with general anesthesia in the last 120 days. Who is currently undergoing pelvic physiotherapy treatment.","FEMALE","45 Years",{"count":231,"type":21},52,[24],"The goal of this clinical trial is to compare the effects of vulvar and intravaginal application of PBM compared to the sham group on pain and sexual function in women with dyspareunia . The main question \\[s\\] it aims to answer are:\n\n* What are the effects of vulvar and intravaginal application of photobiomodulation (PBM) compared to the sham group on the sexual function of women with dyspareunia in the immediate post-intervention moments and in follow-ups of 15, 30, 90 and 180 days?\n* What are the effects of vulvar and intravaginal application of photobiomodulation (PBM) compared to the sham group on pain in women with dyspareunia in the immediate post-intervention moments and in follow-ups of 15, 30, 90 and 180 days?\n\nParticipants will The GPBM photobiomodulation group will receive, during the 8 days of intervention, application in 8 points (4 red and 4 infrared) in the vulvar region and 8 points (4 red and 4 infrared) in the intravaginal pelvic floor region of PBM while the GS group will receive simulation application of PBM in the same number of vulvar and intravaginal points, in the same places where it was applied in the GPBM group. To see if 8 applications of photobiomodulation are really capable of reducing pain and improving sexual function in women with dyspareunia",[235,236,237],"Dyspareunia","Pain","Sexual Dysfunction",[239,240,241,242,243],"photobiomodulation","dyspareunia","sexual dysfunction","physiotherapy","pelvic pain","2024-06-11",{"date":246,"type":32},"2024-06-14",{"date":248,"type":21},"2024-06",{"date":250,"type":21},"2027-08",{"name":38,"class":39},""]