[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Federal University of Maranhao\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":100},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,45,74],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":4},"100642857","effects-of-physical-training-on-cardiovascular-capacity-in-patients-undergoing-chemotherapy-for-cancer-100642857",false,"NCT07640087","Effects Of Physical Training On Cardiovascular Capacity In Patients Undergoing Chemotherapy For Cancer","Cancer","* Inclusion Criteria:\n\n  * Patients with a confirmed diagnosis of cancer who are undergoing chemotherapy treatment with anthracyclines;\n  * No physical exercise intervention for the past 3 months;\n  * Patients in the early or intermediate stages of cancer treatment;\n  * Adult patients (e.g., 18 to 59 years old) to avoid extreme variations in response to physical exercise;\n  * Clinically stable patients, without absolute contraindications to physical exercise (e.g., decompensated heart failure, severe arrhythmias);\n  * Patients able to participate in a supervised physical exercise program during the study period\n* Exclusion Criteria:\n\n  * Patients with severe pre-existing cardiac conditions (e.g., advanced cardiomyopathy, unstable angina) that prevent safe exercise practice;\n  * Patients with physical (e.g., inability to walk) or cognitive limitations that prevent participation in the physical exercise program;\n  * Patients undergoing treatments that may interfere with the results (e.g., recent thoracic radiotherapy, use of cardiotoxic agents unrelated to the study);\n  * Patients who already engage in regular and intense physical exercise, as this could interfere with the effects of the intervention.","ALL","18 Years","59 Years",{"count":20,"type":21},60,"ESTIMATED","INTERVENTIONAL",[24],"NA","Introduction: Cancer treatment, especially chemotherapy and radiotherapy, can lead to cardiovascular dysfunctions, such as a decrease in left ventricular ejection fraction and electrical dysfunction of the heart, which may consequently compromise patients' quality of life. In this context, physical exercise is a beneficial and promising tool, as it can prevent and minimize the deleterious effects of oncological therapies and their complications.\n\nObjective: To evaluate the effect of physical exercise on the prevention of cardiovascular diseases (CVD) induced by cancer treatment, analyzing the impact of supervised exercise on cardiovascular function and quality of life.\n\nMaterials and Methods: This is a clinical trial in which the sample will consist of 60 individuals undergoing cancer treatment, who will be stratified and randomized according to cancer stage classification into two groups: Intervention Group (IG) and Control Group (CG). The intervention will last 12 weeks, during which the IG will receive a prescription for physical exercises based on the FITT principle (frequency, intensity, time, and type), three times per week, while the CG will remain under usual care. Data will be presented using descriptive statistics, tests for two independent samples, and multivariate analysis, comparing the intervention effects between the two groups using R software version 4.3.3.\n\nExpected Results: Low incidence of CVD, improved heart rate variability, adherence to the exercise protocol, reduced risk for cardiovascular diseases, improvement in fatigue, functional capacity, and quality of life. Data will be collected at baseline, at the 6th week, and at the 12th week of intervention.",[27,28],"Cardiac Abnormalities","Chemotherapeutic Toxicity",[30,31,32],"QUALITY OF LIFE","PAIN","EXERCISE","NOT_YET_RECRUITING","2026-06-23",{"date":36,"type":37},"2026-06-26","ACTUAL",{"date":39,"type":21},"2026-08-05",{"date":41,"type":21},"2027-12-01",{"name":43,"class":44},"Federal University of Maranhao","OTHER",{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":14,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":52,"minAge":17,"maxAge":4,"enrollmentInfo":53,"targetDuration":4,"studyType":22,"phases":55,"briefSummary":56,"conditions":57,"keywords":61,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":4},"100641043","effects-of-a-pilates-studio-program-on-quality-of-life-and-functional-capacity-of-women-undergoing-breast-cancer-treatment-100641043","NCT07599098","Effects of a Pilates Studio Program on Quality of Life and Functional Capacity of Women Undergoing Breast Cancer Treatment","Effects of a Pilates Studio Program on Quality of Life, Functional Capacity, Pain, Fatigue, Sarcopenia, Flexibility, Strength, Body Composition, Self-Esteem, Anxiety and Depression in Women Undergoing Breast Cancer Treatment","Inclusion Criteria:\n\n* Women aged 18 or older;\n* Being under treatment for breast cancer (chemotherapy, radiotherapy, immunotherapy and\u002For hormone therapy);\n* No previous neurological\u002Fmusculoskeletal disorders that impede active movement;\n* No recent surgeries.\n\nExclusion Criteria:\n\n* Patients with problems secondary to breast cancer that limit active movement;\n* Presence of inflammation or edema in the abdomen, groin, and upper and lower extremities;\n* Having another type of cancer;\n* Having a cognitive impairment or injury that prevents them from performing physical assessments or completing questionnaires.","FEMALE",{"count":54,"type":21},50,[24],"Introduction: Cancer treatment generates undesirable effects, directly affecting the functional and psychosocial capacity faced by breast cancer patients during treatment. In order to evaluate the practical effects of a pilates studio program that aims to promote significant improvements in their quality of life, emotional and social well-being. Objective: To assess quality of life, pain, fatigue, sarcopenia, flexibility of upper limbs, functional capacity, functional independence, general flexibility, strength of upper limbs and lower limbs, muscle mass, self-steem, anxiety and depression in women undergoing breast cancer treatment. Method: This is a cross-sectional study in which the sample will be composed of female individuals undergoing cancer treatment who participated in a Pilates studio program, twice a week lasting 60 minutes with light to moderate exercises, the intervention will last 16 weeks. The primary outcomes of study will be quality of life, pain, fatigue, sarcopenia, flexibility of upper limbs, functional capacity, functional independence. The secondary outcomes of study will be general flexibility, strength of upper limbs and lower limbs, muscle mass, self-steem, anxiety and depression in women undergoing breast cancer treatment. All evaluated using instruments: EORTC-QLQ-30 and EORTC-QLQ-23 questionnaires (European Organization for Research and Treatment of Cancer Quality of Life Questionnaire); Brief Pain Inventory; PIPER Fatigue Scale; SARC -F and SARC-Calf questionnaires; Back Scratch Test; Disabilities of the Arm, Shoulder and Hand Questionnaire - DASH; Six-minute walk test (6MWT) and 6-Minute Step Test; Barthel Index; Schober test; Handgrip Strength and 30-second sit-to-stand test; Bioimpedance; Rosenberg Self-Esteem Scale and Hospital Anxiety and Depression Scale (HADS), respectively. The data will be presented by descriptive statistics, for two independent samples and multivariate analysis, comparing the effects of the intervention between the two groups in the R 4.3.3 software. Expected results: Improvement in primary and secondary outcomes due to adjustments in physical training, Pilates studio.",[58,59,60],"Breasts - Female","Breast Cancer","Breast Cancer in Women",[62,63,64,65],"Neoplasia","Pilates","Quality of life","Functional capacity","2026-05-13",{"date":68,"type":37},"2026-05-20",{"date":70,"type":21},"2026-05-15",{"date":72,"type":21},"2026-11-16",{"name":43,"class":44},{"id":75,"slug":76,"hasResults":11,"nctId":77,"briefTitle":78,"officialTitle":79,"acronym":80,"eligibilityCriteria":81,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":82,"targetDuration":4,"studyType":22,"phases":84,"briefSummary":85,"conditions":86,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":99},"100630898","therapeutic-drug-monitoring-of-mycophenolate-mofetil-in-lupus-nephritis-100630898","NCT07493655","Therapeutic Drug Monitoring of Mycophenolate Mofetil in Lupus Nephritis","Impact of Therapeutic Drug Monitoring of Mycophenolate Mofetil in Patients With Lupus Nephritis: A Randomized Clinical Trial","LUPUS-MONITOR","Inclusion criteria:\n\n* Adults aged ≥18 years, of both sexes\n* Diagnosis of systemic lupus erythematosus (SLE) according to the ACR criteria, with at least four criteria present for the diagnosis of SLE, and active lupus nephritis (class III-V) documented by renal biopsy with histological classification within the last 6 months or presence of urine protein-to-creatinine ratio (UPCR \\> 0.5) or 24-hour proteinuria (\\>500 mg)\n* Use of mycophenolate mofetil (MMF) in the maintenance phase within the first 3 months\n* Residents of the municipalities of São Luís, São José de Ribamar, and Paço do Lumiar, located in the Metropolitan Region of Greater São Luís\n\nExclusion criteria:\n\n* Individuals with contraindications to MMF (known hypersensitivity, pregnancy, or breastfeeding)\n* Active severe infection (e.g., tuberculosis, sepsis)\n* Unstable renal replacement therapy and severe hepatic failure\n* Use of investigational drugs\n* Concomitant use of drugs that strongly modify pharmacokinetics (PK) without the possibility of adjustment, such as rifampicin.",{"count":83,"type":21},100,[24],"Systemic lupus erythematosus (SLE) is an inflammatory, chronic, and multisystem autoimmune disease characterized by periods of activity and remission. Lupus nephritis (LN) is the most frequent renal complication and is associated with high morbidity, manifesting as nephritic or nephrotic syndrome, complement consumption, and positivity for anti-double-stranded DNA antibodies.\n\nMycophenolate mofetil (MMF) is an immunosuppressive agent that modifies the course of LN and is converted into mycophenolic acid (MPA), its measurable active metabolite. However, MMF exhibits complex interindividual and interethnic variability in metabolism, reinforcing the need for personalized strategies through therapeutic drug monitoring (TDM) to ensure renal remission.\n\nThe objective of this study is to determine whether the implementation of MPA TDM results in a higher rate of renal remission over 12 months compared with standard treatment.\n\nThis is a randomized, blinded clinical trial to be conducted at a teaching hospital in Maranhão over a 12-month period. From an estimated population of 187 eligible patients with LN receiving MMF, 100 consecutive participants will be randomized (50 per group).\n\nMPA monitoring will occur at three time points (T1, T2, T5), while clinical and laboratory outcome assessments will be performed quarterly (T1-T5). The primary outcome will be the renal remission rate; secondary outcomes include serum MPA levels, adverse events, hospitalizations, and medication adherence.\n\nThis study will generate evidence on precision therapeutics applied to MMF in LN within the Brazilian public health system (SUS), particularly regarding the pilot use of TDM for dose optimization and maximization of clinical response.",[87,88,89,90],"Systemic Lupus Erythematosus","Lupus Nephritis","Drug Monitoring","Mycophenolic Acid","2026-03-23",{"date":93,"type":37},"2026-03-25",{"date":95,"type":21},"2026-07-01",{"date":97,"type":21},"2028-12-31",{"name":43,"class":44},1,""]