[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Federal University of Piaui\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":155},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,47,71,99,129],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":4},"100598736","effect-of-an-exercise-program-on-clinical-aspects-of-people-with-diabetic-peripheral-neuropathy-100598736",false,"NCT07075367","Effect of an Exercise Program on Clinical Aspects of People With Diabetic Peripheral Neuropathy","Effect of a Trunk, Hip, Knee and Ankle Exercise Program on Clinical Aspects of People With Diabetic Peripheral Neuropathy: a Randomized Clinical Trial","Inclusion Criteria:\n\n* Adult individuals aged between 45 and 75 years, male or female, diagnosed with DM2;\n* DPN diagnosis based on vibration sensitivity tests assessed by a 128 Hz tuning fork and tactile sensitivity measured by a 10 g monofilament\n* Sedentary or irregularly active individuals (level A) according to the Physical Activity Level Classification - IPAQ\n* Score of at least 5 points on the Functional Independence Measure (FIM), i.e., requires supervision, but without physical contact\n* Absence of diabetic foot ulcer (DFU) for at least one month\n* No amputation or at most amputation of fingers, except for the hallux\n\nExclusion Criteria:\n\n* Individuals involved in physical training programs simultaneously with the intervention\n* History of surgical intervention in the lower limbs or spine\n* Use of walking assistance devices\n* Diagnosis of severe cardiovascular disorder\n* Diagnosis of other neurological impairments in addition to DPN\n* Presence of dementia or inability to provide consistent information\n* Severe retinopathy","ALL","45 Years","75 Years",{"count":20,"type":21},64,"ESTIMATED","INTERVENTIONAL",[24],"NA","Diabetic Peripheral Neuropathy (DPN) is one of the most prevalent and debilitating complications of type 2 diabetes mellitus (DM2), especially affecting the distal region of the lower limbs. Such changes affect clinical aspects, such as quality of life. Several pieces of evidence point to therapeutic exercises as an effective way to minimize these deficits. This is a single-blind randomized clinical trial in which participants will be randomly assigned to two groups. The stipulated sample size was 64 participants. The experimental group will receive a distal\u002Fproximal exercise program and the control group will receive a distal exercise program available in the literature and previously tested. The intervention will last 12 weeks and will take place twice a week, with an average time of 50 minutes. Neuropathic symptoms will be considered primary outcomes. The secondary outcomes evaluated will be: capillary blood glucose, Mini-BESTest, Falls Efficacy Scale (FES), EQ-5D and HADS (depression and anxiety). This study was approved by the local research ethics committee (Opinion 6.802.243), conducted in accordance with the Declaration of Helsinki and in accordance with the CONSORT guidelines.",[27],"Diabetic Peripheral Neuropathy",[29,30,31,32,33,34],"Diabetic peripheral neuropathy","Exercise therapy","Neuropathy symptoms","Quality of life","Depression","Anxiety","NOT_YET_RECRUITING","2025-10-01",{"date":38,"type":39},"2025-10-02","ACTUAL",{"date":41,"type":21},"2026-01-10",{"date":43,"type":21},"2028-01",{"name":45,"class":46},"Federal University of Piaui","OTHER",{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":54,"targetDuration":4,"studyType":22,"phases":55,"briefSummary":56,"conditions":57,"keywords":58,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":4},"100600654","effect-of-an-exercise-program-on-motor-dysfunctions-caused-by-diabetic-peripheral-neuropathy-100600654","NCT07100301","Effect of an Exercise Program on Motor Dysfunctions Caused by Diabetic Peripheral Neuropathy","Effect of a Trunk, Hip, Knee, and Ankle Exercise Program on Motor Dysfunctions Caused by Diabetic Peripheral Neuropathy: a Randomized Clinical Trial","Inclusion Criteria:\n\n* Adult individuals aged between 45 and 75 years, male or female, diagnosed with DM2\n* DPN diagnosis based on vibration sensitivity tests assessed by a 128 Hz tuning fork and tactile sensitivity measured by a 10 g monofilament\n* Sedentary or irregularly active individuals (level A) according to the Physical Activity Level Classification - IPAQ\n* Score of at least 5 points on the Functional Independence Measure (FIM), i.e., requires supervision, but without physical contact\n* Absence of diabetic foot ulcer (DFU) for at least one month\n* No amputation or at most amputation of fingers, except for the hallux\n\nExclusion Criteria:\n\n* Individuals involved in physical training programs simultaneously with the intervention\n* History of surgical intervention in the lower limbs or spine\n* Use of walking assistance devices\n* Diagnosis of severe cardiovascular disorder\n* Diagnosis of other neurological impairments in addition to DPN\n* Presence of dementia or inability to provide consistent information\n* Severe retinopathy",{"count":20,"type":21},[24],"Diabetic Peripheral Neuropathy (DPN) affects approximately half of people with Diabetes Mellitus (DM). Its repercussions on the musculoskeletal system and biomechanics mainly impact balance and locomotor function. Therefore, this study is justified by the need to design effective treatment alternatives for the motor alterations observed in people with DPN. The objective of this study will be to evaluate the effectiveness of an exercise program for the trunk, hip, knee and ankle, consisting of muscle strengthening and sensorimotor training, in the treatment of motor deficits caused by DPN. This will be a single-blind randomized clinical trial in which 64 individuals with type 2 DM and DPN will be randomly distributed between the experimental and control groups. The primary outcome will be the kinematic analysis of gait. The secondary outcomes will be: muscle strength assessed by dynamometry and the 30-second sit-to-stand test (30STS), and functional mobility through the Timed Up and Go (TUG) test. Assessments will be performed before the start of the intervention, at the end of the intervention, and at the one-month follow-up. The experimental group will perform a 12-week proximal\u002Fdistal exercise program (trunk, hip, knee, and ankle). The control group will perform a distal exercise program (ankle and foot). The proposed exercise program is expected to show consistently positive results compared to the control group.",[27],[29,59,60,61,62],"Biomechanic","Gait","Muscle strength","Kinematics","2025-07-27",{"date":65,"type":39},"2025-08-03",{"date":67,"type":21},"2025-08",{"date":69,"type":21},"2028-08",{"name":45,"class":46},{"id":72,"slug":73,"hasResults":11,"nctId":74,"briefTitle":75,"officialTitle":76,"acronym":4,"eligibilityCriteria":77,"healthyVolunteers":11,"sex":16,"minAge":78,"maxAge":4,"enrollmentInfo":79,"targetDuration":4,"studyType":22,"phases":81,"briefSummary":82,"conditions":83,"keywords":88,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":95,"completionDateStruct":96,"leadSponsor":98,"locationsCount":4},"100596316","effects-and-feasibility-of-photobiomodulation-at-830nm-nanometers-in-the-treatment-of-diabetic-ulcers-100596316","NCT07043868","Effects and Feasibility of Photobiomodulation at 830nm Nanometers in the Treatment of Diabetic Ulcers","Effects and Feasibility of Photobiomodulation at 830 Nanometers in the Treatment of Diabetic Ulcers: a Randomized, Double-blind Clinical Trial","Inclusion Criteria:\n\n* Volunteers of both sexes\n* Age over 18 years\n* Medical diagnosis of diabetes mellitus (DM)\n* Presence of diabetic ulcer\n\nExclusion Criteria:\n\n* Autoimmune diseases\n* Infected diabetic ulcers\n* Osteomyelitis\n* Ischemia\n* Concomitant psychiatric disorders\n* Contraindications to treatment methods","18 Years",{"count":80,"type":21},136,[24],"Diabetic foot ulcers (DFU) are among the late complications of DFU, defined as skin lesions that involve the dermis to deeper structures, such as muscles and bones. Although preclinical studies have demonstrated the effects of GaAs 830 nm in diabetic wounds, no clinical studies have been performed, revealing the need for more in-depth analyses to identify the effects and ideal parameterization of PBM with GaAs 830 nm wavelength in the treatment of diabetic ulcers, improving quality of life, as well as to understand the therapeutic feasibility, time required for healing and recurrence rates of these lesions. Experimental, randomized, controlled, double-blind study, with blinding applied to the evaluator and participants. A total of 136 volunteers will be recruited for the research, carried out at the Integrated Center of Medical Specialties (CIEM) - Polyclinic. LLLT GaAs 830nm will be used with three dosages of low, medium and high intensity (4 J\u002Fcm², 8 J\u002Fcm², 12 J\u002Fcm²). The study will have three intervention groups using LLLT with GaAs 830nm and a control group, in which LLLLT will be performed with a GaAs 904nm wavelength and a dose of 10 J\u002Fcm², according to Saura et al (2024). This study was approved by the local Research Ethics Committee (Opinion 7,488,044), conducted in accordance with the Declaration of Helsinki and in accordance with the CONSORT (Consolidated Standards of Reporting Trials) guidelines.",[84,85,86,87],"Diabete Type 2","Diabetic Foot Ulcer","Photobiomodulation","Low Level Laser Therapy",[89,90,91],"diabetic foot ulcer","photobiomodulation","low level laser therapy","2025-07-05",{"date":94,"type":39},"2025-07-10",{"date":41,"type":21},{"date":97,"type":21},"2028-01-10",{"name":45,"class":46},{"id":100,"slug":101,"hasResults":11,"nctId":102,"briefTitle":103,"officialTitle":104,"acronym":105,"eligibilityCriteria":106,"healthyVolunteers":11,"sex":16,"minAge":78,"maxAge":4,"enrollmentInfo":107,"targetDuration":4,"studyType":22,"phases":109,"briefSummary":110,"conditions":111,"keywords":115,"overallStatus":119,"whyStopped":4,"lastUpdateSubmitDate":120,"lastUpdatePostDateStruct":121,"startDateStruct":123,"completionDateStruct":125,"leadSponsor":127,"locationsCount":128},"100517659","pedicle-screw-malposition-in-spine-arthrodesis-surgeries-with-o-arm-guided-navigation-100517659","NCT06020417","Pedicle Screw Malposition in Spine Arthrodesis Surgeries With O-ARM-guided Navigation","Occurrence of Pedicle Screw Malposition in Spine Arthrodesis Surgeries Performed With O-ARM-guided Navigation at a University Hospital: a Randomized Controlled Trial","NoHARM","Inclusion Criteria:\n\n* spine deformities (spinal cord trauma, osteoarthritis, intervertebral disc degeneration, degenerative or isthmic spondylolisthesis, intervertebral disc degeneration, spinal stenosis and degenerative scoliosis).\n\nExclusion Criteria:\n\n* anatomical abnormalities that can not be used the neuronavigation.",{"count":108,"type":21},124,[24],"Background: Throughout the history of spinal deformity there have been continuous advances in the surgical treatment. Although many techniques have been successfully developed despite the anatomy complex, screw placement still remains difficult with a significant risk of misplaced implants. The O-ARM guided Navigation is a scanner that allows imaging of screws intraoperatively and could be a tool to facilitate screw revision and reduce the occurrence of misplaced implants. Methods: This is a prospective and randomized clinical study that will be carried out at the University Hospital of the Federal University of Piaui, which provides exclusive assistance to patients of the Unified Health System (UHS), in northeastern Brazil.",[112,113,114],"Spinal Fusion","Spinal Deformity","Spine Injury",[116,117,118],"neuronavigation","spinal deformity","Spine injury","RECRUITING","2024-09-24",{"date":122,"type":39},"2024-09-25",{"date":124,"type":39},"2024-08-01",{"date":126,"type":21},"2025-12-31",{"name":45,"class":46},1,{"id":130,"slug":131,"hasResults":11,"nctId":132,"briefTitle":133,"officialTitle":134,"acronym":4,"eligibilityCriteria":135,"healthyVolunteers":11,"sex":16,"minAge":78,"maxAge":4,"enrollmentInfo":136,"targetDuration":138,"studyType":139,"phases":4,"briefSummary":140,"conditions":141,"keywords":145,"overallStatus":119,"whyStopped":4,"lastUpdateSubmitDate":120,"lastUpdatePostDateStruct":149,"startDateStruct":150,"completionDateStruct":152,"leadSponsor":154,"locationsCount":128},"100396116","accuracy-of-cardiac-arrhythmias-and-conduction-disorders-diagnosis-using-a-smartwatch-100396116","NCT04437914","Accuracy of Cardiac Arrhythmias and Conduction Disorders Diagnosis Using a Smartwatch","Accuracy of Cardiac Arrhythmias and Conduction Disorders Diagnosis Using Smartwatch in Comparison to Conventional Electrocardiogram in Patients With Cardiovascular Disease","Inclusion Criteria:\n\n* Age ≥ 18 years;\n* Presence of one or more of the following diagnoses: systemic arterial hypertension, heart failure, valve disease, coronary atherosclerotic disease, myocardial infarction, endocarditis, myocarditis, diabetes, cardiac arrhythmias and patients with cardiac pacemakers or implantable automatic defibrillators.\n\nExclusion Criteria:\n\n* Patients who have electrocardiographic tracings, whether obtained from the watch or the conventional method, of poor quality that make it impossible or that makes the diagnosis difficult due to the technical aspect of the performance.\n* Withdrawal of the consent form at the request of the patient or guardian.",{"count":137,"type":21},110,"6 Months","OBSERVATIONAL","Implantable devices increase the detection of silent atrial fibrillation in high-risk populations, being a useful tool in the early diagnosis of these patients, allowing monitoring for a longer time. Currently, these devices can be used for monitoring and possible early diagnosis of abnormalities in order to prevent health complications and bring about better outcomes, as well as monitor the user's progress and thus prevent more serious developments. Objective: to analyze, in patients with cardiovascular disease, the electrocardiographic aspects detected from the device in comparison to the conventional electrocardiogram, identifying aspects of similarity between the tracings obtained and automatic diagnostic accuracy by the device and by the visual assessment of the tracing. Method: a cross-sectional observational study of diagnostic accuracy will be carried out at the University Hospital of the Federal University of Piaui. The following parameters were considered: significance level of 95%, test power of 80%, value of the disease diagnosis rate of 84%, area under the receiver operating characteristic curve of 94% and an equal proportion of the number of positive and negative cases. The minimum sample size consisted of 100 patients, and an additional 10% will be added to compensate for possible losses. A total of 110 patients will be invited to participate in the study. Patients aged ≥ 18 years will be included, with the presence of one or more diagnoses below: systemic arterial hypertension, heart failure, valvular disease, coronary atherosclerotic disease, myocardial infarction, endocarditis, myocarditis, diabetes, cardiac arrhythmias and patients with cardiac pace or implantable automatic defibrillator. The variables analyzed will be: clinical-demographic data of the patients, including age, sex, race, socioeconomic profile; comorbidities and electrocardiographic findings as measured by the clock and conventional ECG. The data will be analyzed comparatively between the groups: 1 = EKG on the clock; 2 = 12-lead conventional EKG and DI (single lead). The primary outcome will be the positive diagnostic correlation of the data obtained in group 1 in relation to group 2. Secondary outcomes: successful measurement of the electrocardiographic record by the clock; diagnostic accuracy of atrial fibrillation and other heart rhythm disorders.",[142,143,144],"Cardiovascular Diseases","Cardiac Arrhythmia","Conduction Disturbance",[146,143,147,148],"Artificial Intelligence","Smartwatch","Cardiac Conduction System Disturbance",{"date":122,"type":39},{"date":151,"type":39},"2021-06-07",{"date":153,"type":21},"2025-06-30",{"name":45,"class":46},""]