[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Federal University of Rio Grande do Sul\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":237},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,8,0,[8,48,75,101,132,159,185,215],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":33,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100638363","photobiomodulation-effects-on-fatigue-and-muscle-damage-induced-by-nmes-100638363",false,"NCT07602933","Photobiomodulation Effects on Fatigue and Muscle Damage Induced by NMES","Effects of Photobiomodulation on Fatigue and Muscle Damage Induced by Neuromuscular Electrical Stimulation in Healthy Individuals: a Randomized Clinical Trial","Inclusion Criteria:\n\n* Healthy male and female volunteers.\n* Age between 18 and 45 years.\n* Practice physical activity regularly\n* No history of musculoskeletal injuries in the lower limbs in the last 6 months\n* Ability to tolerate NMES\n\nExclusion Criteria:\n\n* Have sensory intolerable changes due to NMES\n* Consumed coffee or another stimulant in the last 12 hours\n* Have a body mass index (BMI) greater than 30 kg\u002Fm2 (grade I obesity)\n* Present any contraindication for the performance of maximum effort\n* Abnormal increase in blood pressure after maximal exertion",true,"ALL","18 Years","45 Years",{"count":21,"type":22},36,"ESTIMATED","INTERVENTIONAL",[25],"NA","Neuromuscular electrical stimulation (NMES) is widely used to improve muscle strength and mitigate atrophy. However, its clinical efficacy is often limited by early neuromuscular fatigue, muscle damage, and discomfort, which reduce patient tolerance and contraction time. Photobiomodulation (PBM) has emerged as a potential therapy to enhance muscle performance and accelerate recovery by minimizing fatigue and damage. Despite its potential, few studies have investigated the effects of PBM applied specifically before an NMES-evoked fatigue protocol. This randomized, double-blind, placebo-controlled trial aims to evaluate the acute effects of PBM on neuromuscular fatigue, muscle damage, and functional outcomes in healthy young subjects. Participants will receive either active PBM (cluster probe: 5 lasers 810nm\u002F200mW; 4 LEDs 660nm\u002F10mW; Total Energy: 249.6 J per limb) or sham treatment 5 minutes before a fatiguing NMES protocol (80 contractions at 20% MVIC, 80 Hz, 1ms pulse width) applied to the quadriceps muscle. Assessments will be performed at baseline, immediately post-intervention, and at 24h, 48h, and 72h post-intervention. Primary outcomes include maximum and evoked isometric strength, mechanical work, and electrical muscle activity. Secondary outcomes include muscle damage (ultrasound echo-intensity), delayed onset muscle soreness (DOMS), functional performance (unilateral vertical jump), and clinical discomfort. The study seeks to determine if PBM can effectively modulate NMES-induced fatigue and muscle damage, potentially optimizing its clinical application.",[28,29,30,31,32],"Photobiomodulation","Fatigue","Discomfort","Electrical Stimulation","Muscle Damage",[28,29,30,32,34],"Electrical stimulation","RECRUITING","2026-06-24",{"date":38,"type":39},"2026-06-25","ACTUAL",{"date":41,"type":22},"2026-06-01",{"date":43,"type":22},"2026-09-30",{"name":45,"class":46},"Federal University of Rio Grande do Sul","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":17,"minAge":55,"maxAge":4,"enrollmentInfo":56,"targetDuration":4,"studyType":23,"phases":58,"briefSummary":59,"conditions":60,"keywords":63,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":74},"100636425","effects-of-a-multicomponent-exercise-program-in-older-adults-undergoing-cancer-treatment-a-randomized-controlled-trial-100636425","NCT07565519","Effects of a Multicomponent Exercise Program in Older Adults Undergoing Cancer Treatment: A Randomized Controlled Trial","Effects of a Multicomponent Exercise Program on Functional Capacity, Neuromuscular Parameters, Quality of Life, and Disease-Related Symptoms in Older Adults Undergoing Cancer Treatment: A Randomized, Controlled Clinical Trial","Inclusion Criteria: Men and women aged 60 years or older who are undergoing cancer treatment at Hospital Conceição in Porto Alegre, who have the cognitive ability to understand the exercises, are able to walk (even with assistance), and have medical clearance to participate in physical exercise will be included in the study.\n\n\\-\n\nExclusion Criteria: Participants who miss more than two assessments will be excluded.\n\n\\-","60 Years",{"count":57,"type":22},180,[25],"This study aims to understand how a home-based exercise program can help improve strength, mobility, and quality of life in older adults receiving cancer treatment.\n\nParticipants will be randomly divided into two groups:\n\nOne group will follow a one-year multicomponent exercise program based on the ViviFrail model, done safely at home.\n\nThe other group will continue with usual care.\n\nWe will include men and women aged 60 or older treated at Hospital Conceição in Porto Alegre. Assessments will take place at the beginning and after 12, 24, and 48 weeks.\n\nWe will measure walking speed, balance, muscle strength, and ask about quality of life, symptoms, and daily activity.\n\nThe goal is to see whether home-based exercise can help older adults with cancer stay stronger, more independent, and feel better during treatment.",[61,62],"Cancer","Aging",[62,64,65],"Neoplasia","Physical activity","2026-04-27",{"date":68,"type":39},"2026-05-04",{"date":70,"type":39},"2026-03-02",{"date":72,"type":22},"2027-06-01",{"name":45,"class":46},2,{"id":76,"slug":77,"hasResults":11,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":4,"eligibilityCriteria":81,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":82,"targetDuration":4,"studyType":23,"phases":84,"briefSummary":85,"conditions":86,"keywords":90,"overallStatus":93,"whyStopped":4,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":97,"completionDateStruct":98,"leadSponsor":100,"locationsCount":4},"100628381","effectiveness-of-photobiomodulation-for-myofascial-pain-in-temporomandibular-disorders-100628381","NCT07460895","Effectiveness of Photobiomodulation for Myofascial Pain in Temporomandibular Disorders","Photobiomodulation in the Management of Myofascial Pain: A Randomized and Blinded Clinical Trial","Inclusion Criteria:\n\n* Individuals with myofascial TMD (ICD-9 729.1; ICD-10 M79.1) diagnosed according to the DC\u002FTMD criteria;\n* Participants aged 18 years or older;\n* Individuals able to communicate, read, write, and provide written informed consent in Portuguese.\n\nExclusion Criteria:\n\n* Patients with a history of autoimmune connective tissue diseases, such as rheumatoid arthritis, psoriatic arthritis, scleroderma, or systemic lupus erythematosus;\n* History of malignancy in the head and neck region within the past 2 years (except basal cell carcinoma) who have undergone head and neck radiation therapy and\u002For surgery affecting facial muscles;\n* Patients who have undergone temporomandibular joint surgery or orthognathic surgery;\n* Pregnant or breastfeeding women;\n* Patients with poorly adapted prostheses and\u002For prostheses associated with inadequate increase or decrease of the vertical dimension;\n* Patients with a history of tardive dyskinesia or oromandibular\u002Fcervical dystonia; -Patients with maximum mouth opening less than 35 mm;\n* Patients using systemic medications with a potential effect on pain at the time of screening will not be included in the study, including analgesics, anti-inflammatory drugs, muscle relaxants, corticosteroids, or other medications with analgesic and\u002For anti-inflammatory effects.\n\nIf a participant initiates the use of any such medication during the follow-up period, the participant will be excluded from the study.\n\n\\- Patients receiving oral and\u002For intravenous corticosteroid bolus therapy at doses \\> 1 mg\u002Fkg within the past 3 months, and those receiving biologic agents within 1 month or five times the drug half-life, whichever is longer; Individuals with mental or psychological conditions that may prevent participation in the study.",{"count":83,"type":22},140,[25],"This randomized clinical trial aims to evaluate the effectiveness of photobiomodulation therapy (PBM) alone or combined with therapeutic exercises compared with placebo PBM associated with exercises in patients with myofascial temporomandibular disorders (TMD). Participants will be allocated into three groups: PBM alone, PBM combined with exercises, or placebo PBM combined with exercises. The intervention consists of 12 treatment sessions. Outcomes related to pain intensity, mandibular function, and clinical measures will be assessed over time. The study seeks to investigate whether PBM provides additional benefits in pain reduction and functional improvement in individuals with myofascial TMD.",[28,87,88,89],"Temporomandibular Disorder (TMD)","Myofacial Pain","Pain Management",[28,91,92,89],"Myofascial Pain","Temporomandibular Disorder","NOT_YET_RECRUITING","2026-03-05",{"date":96,"type":39},"2026-03-10",{"date":96,"type":22},{"date":99,"type":22},"2030-12",{"name":45,"class":46},{"id":102,"slug":103,"hasResults":11,"nctId":104,"briefTitle":105,"officialTitle":106,"acronym":4,"eligibilityCriteria":107,"healthyVolunteers":16,"sex":108,"minAge":18,"maxAge":109,"enrollmentInfo":110,"targetDuration":4,"studyType":23,"phases":112,"briefSummary":113,"conditions":114,"keywords":118,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":124,"lastUpdatePostDateStruct":125,"startDateStruct":127,"completionDateStruct":129,"leadSponsor":131,"locationsCount":47},"100586199","effects-of-strength-training-on-the-plantar-flexors-properties-after-achilles-tendon-rupture-100586199","NCT06912269","Effects of Strength Training on the Plantar Flexors' Properties After Achilles Tendon Rupture","Effects of Strength Training at Different Intensities on the Plantar Flexors' Functional, Neuromuscular, and Tendon Properties After Achilles Tendon Rupture","Inclusion Criteria:\n\n* Men aged 18 to 64 who have ruptured their Achilles tendon unilaterally no more than 5 years ago;\n* Who are not performing systematic and regular calf strength training.\n\nExclusion Criteria:\n\n* Non-surgical treatment for Achilles tendon rupture;\n* History of postsurgical complications (infection or re-rupture);\n* Presence of any type of ankle injury in the last six month;\n* Participation in a strength training program for plantar flexors in the last six months prior to participation in the study;\n* Having heart failure; autoimmune diseases; and\u002For diabetes;\n* Systematic use of antibiotics or steroids within the last 12 months;\n* Presence of any other clinical contraindication for performing maximum strength tests.","MALE","64 Years",{"count":111,"type":22},67,[25],"Among the injuries that affect the Achilles tendon, rupture is one of the most frequent. This injury can generate functional, neuromuscular, and tendon deficits that can last for long periods or even be permanent. In the long term (i.e., more than a year after the injury), individuals present functional impairments related to the lower limb, deficits in the capacity to produce muscle force, as well as higher levels of muscle activation (as a compensatory response). Such changes may be due to injury adaptations in the plantar flexor muscles' architecture, which may have shorter, more pennate fibers, leading to reduced muscle thickness. Furthermore, the Achilles tendon may be elongated, with a greater cross-sectional area, presenting lower stiffness and quality (i.e., lower Young's modulus). Strength training can play an important role in recovering from Achilles tendon ruptures, as it promotes functional, neuromuscular, and tendon adaptations that can minimize deficits caused by the injury. However, there is a gap in the literature regarding strength training, as well as the dose vs response relationship, regarding functional, neuromuscular, and tendon adaptations after Achilles tendon rupture. Thus, the aim of the present study is to compare the effects of a strength training program of different intensities on plantar flexors' functional, neuromuscular, and tendon outcomes after Achilles tendon rupture. Men aged between 20 and 50 years old who suffered a total unilateral rupture of the Achilles tendon between one and five years after the rupture will be included in the study, as well as healthy men who did not suffer the rupture (control group). Participants who have suffered an Achilles tendon rupture will undergo a progressive lower limb strength training program twice a week for a total duration of 12 weeks, which will be randomized between two groups: low intensity (G55 - 55% of 1-RM) and moderate intensity (G70 - 70% of 1-RM). The following outcomes will be evaluated: a) Achilles tendon's morphological (length and cross-sectional area), mechanical (force-elongation relationship and stiffness) and material (stress-strain relationship and Young's modulus) properties; b) triceps surae muscles' morphological (architecture \\[fascicle length, pennation angle and thickness\\] and quality \\[measured by echointensity and specific tension\\]) properties; c) ankle functionality (maximum height in the heel raise test); d) the plantar flexors' force production capacity (peak and rate of torque development in different joint positions); e) the plantar flexors' muscle voluntary activation; and f) triceps suraes' neuromuscular capacity (i.e., recruitment curves). Assessments will be performed at two times (pre-training; and after 12 weeks of training \\[post-12\\]) through functional tests, ultrasound techniques, isokinetic dynamometry, electromyography, and percutaneous electrical stimulation. An intraclass correlation coefficient will be used to verify the test-retest reproducibility of ultrasound measurements. The Chi-Square test will be used to compare the level of physical activity (pre-training) between the groups. The results of the intervention will be expressed using descriptive statistics (mean, standard deviation, and standard error). The normality and sphericity of the data will be tested using the Shapiro-Wilk and Mauchly tests, respectively. A generalized estimating equation, followed by Bonferroni post-hoc, will be used to compare the effects of groups (G55 and G70) and times (pre-training, Post-6, and Post-12). A one-way ANOVA, followed by a Bonferroni post-hoc, will be used to compare the control group participants' limbs with the healthy and injured limbs from both intervention groups (G55 and G70) in the Pre and Post-12 times. The effect size will be estimated for each outcome. All statistical analyzes will be performed using SPSS software.",[115,116,117],"Achilles Tendon Rupture","Strength Training Adaptations","Neuromuscular Adaptations",[119,120,121,122,123],"Neuromuscular plasticity","Stiffness","Functionality","Triceps surae","Calcaneal tendon rupture","2026-01-28",{"date":126,"type":39},"2026-01-30",{"date":128,"type":39},"2024-10-10",{"date":130,"type":22},"2026-08-30",{"name":45,"class":46},{"id":133,"slug":134,"hasResults":11,"nctId":135,"briefTitle":136,"officialTitle":136,"acronym":4,"eligibilityCriteria":137,"healthyVolunteers":16,"sex":138,"minAge":18,"maxAge":139,"enrollmentInfo":140,"targetDuration":4,"studyType":23,"phases":142,"briefSummary":143,"conditions":144,"keywords":146,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":151,"lastUpdatePostDateStruct":152,"startDateStruct":154,"completionDateStruct":156,"leadSponsor":158,"locationsCount":47},"100600607","perineal-massage-during-labor-for-the-prevention-of-perineal-trauma-100600607","NCT07099690","Perineal Massage During Labor for the Prevention of Perineal Trauma","Inclusion Criteria:\n\n* Patients currently in labor\n* Gestational age between 37 and 42 weeks\n* Fetus presenting in cephalic position\n* No prior perineal massage performed during prenatal care\n\nExclusion Criteria:\n\n* Patients who progress to cesarean delivery\n* Diagnosis of HELLP syndrome\n* Unstable vital signs of the laboring woman or fetus","FEMALE","50 Years",{"count":141,"type":22},466,[25],"The purpose of this study is to evaluate whether perineal massage during labor can help prevent perineal trauma, such as lacerations or episiotomies.\n\nThe study will test two hypotheses:\n\nNull hypothesis: Perineal massage during labor does not prevent perineal trauma.\n\nAlternative hypothesis: Perineal massage during labor helps prevent perineal trauma.\n\nParticipants will be randomly assigned to one of two groups:\n\nPerineal massage group: Participants will receive perineal massage during labor.\n\nControl group: Participants will receive the standard care provided by the labor and delivery unit.\n\nA randomization process will be used to assign participants to each group.",[145],"Obstetric; Injury Pelvic Floor",[147,148,149,150],"Perineal trauma","Episiotomy","Perineal massage","Laceration","2025-08-19",{"date":153,"type":39},"2025-08-26",{"date":155,"type":39},"2024-04-02",{"date":157,"type":22},"2026-12-15",{"name":45,"class":46},{"id":160,"slug":161,"hasResults":11,"nctId":162,"briefTitle":163,"officialTitle":164,"acronym":4,"eligibilityCriteria":165,"healthyVolunteers":11,"sex":17,"minAge":139,"maxAge":166,"enrollmentInfo":167,"targetDuration":4,"studyType":23,"phases":169,"briefSummary":170,"conditions":171,"keywords":173,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":177,"lastUpdatePostDateStruct":178,"startDateStruct":180,"completionDateStruct":182,"leadSponsor":184,"locationsCount":74},"100590444","effects-of-amazonian-dance-on-motor-and-non-motor-symptoms-of-people-with-parkinsons-study-protocol-100590444","NCT06967493","Effects of Amazonian Dance on Motor and Non-motor Symptoms of People With Parkinson's: Study Protocol","\"Amazonian Dance for Parkinson\": a Protocol Study for a Randomized Clinical Trial on Motor and Non-motor Symptoms of People With Parkinson's.","Inclusion Criteria:\n\n* Confirmed diagnosis of PD according to the London Brain Bank Criteria;\n* Able to understand the verbal instructions for the tests;\n* Hoehn and Yahr (H\\&Y) stages I-III\n* ≥ 1 year undergoing medical treatment for PD with regular use of anti-parkinsonian drugs\n* Capability to participate will be based on the Unified Parkinson's Disease Rating Scale -motor examination\n\nExclusion Criteria:\n\n* Recent surgeries,\n* Deep brain stimulation (DBS);\n* Other associated neurological diseases or chronic diseases\n* Fitted with a pacemaker;\n* Prostheses in the lower limbs;","80 Years",{"count":168,"type":22},80,[25],"This randomized controlled trial aims to evaluate the effects of a 12-week Amazonian dance program on cognitive and motor symptoms in people with Parkinson's disease (PD), comparing outcomes between participants in the intervention and those in an alternative control intervention.",[172],"Parkinson Disease",[174,175,176],"Dance","Cognition","Non-motor symptoms","2025-05-02",{"date":179,"type":39},"2025-05-13",{"date":181,"type":22},"2025-08-04",{"date":183,"type":22},"2026-06-30",{"name":45,"class":46},{"id":186,"slug":187,"hasResults":11,"nctId":188,"briefTitle":189,"officialTitle":190,"acronym":191,"eligibilityCriteria":192,"healthyVolunteers":16,"sex":17,"minAge":55,"maxAge":4,"enrollmentInfo":193,"targetDuration":4,"studyType":23,"phases":195,"briefSummary":196,"conditions":197,"keywords":200,"overallStatus":93,"whyStopped":4,"lastUpdateSubmitDate":207,"lastUpdatePostDateStruct":208,"startDateStruct":210,"completionDateStruct":212,"leadSponsor":214,"locationsCount":4},"100565170","crem---clinical-and-functional-outcomes-in-a-controlled-clinical-trial-with-older-adults-100565170","NCT06638697","CREM - Clinical and Functional Outcomes in a Controlled Clinical Trial with Older Adults","CREM - Reference Center for Aging and Movement: Clinical and Functional Outcomes in a Controlled Clinical Trial with Older Adults","CREM","Inclusion Criteria:\n\n* elderly people over 60 years old,\n* sex female our male,\n* presenting medical authorization to practice exercises,\n* being able to understand verbal instructions for carrying out the tests,\n* having accessibility to carry out the training,\n* coming from local Health Units and the community,\n* presenting independent walking and not having participated in any physical activity for at least three months before starting the research.\n\nExclusion Criteria:\n\n* not having a medical certificate indicating that they are fit to perform physical activity,\n* presenting medical comorbidities and\u002For a medical condition that contraindicates participation in the study, severe heart disease, uncontrolled arterial hypertension, myocardial infarction within a period of less than one year or history of physical-cognitive impairment, sequelae of a stroke,\n* having a pacemaker,\n* having undergone recent surgery,\n* prosthetics in the lower limbs or neuropathic pain in the lower limbs.",{"count":194,"type":22},240,[25],"To evaluate and compare the effects of different types of physical exercise on clinical and functional outcomes in the elderly. 240 community-dwelling elderly individuals of both sexes, sedentary, will be recruited for twelve groups of elderly individuals who will receive intervention for 32 weeks of different types of physical exercise (free walking, Nordic walking, dancing, physical exercise for cognition, balance, aquatic physiotherapy, multicomponent gymnastics, water aerobics, hydro-postural exercises, aquatic jogging, weight training, and Pilates mat). The training programs will have a frequency of two sessions per week and will last 50 minutes and will be periodized so that the duration of the sessions is equal among them. In order to evaluate the effects of the training, evaluations will be carried out before, during and after the training period of functional fitness, clinical-functional and biomechanical parameters. It is expected that the intervention groups will present results according to the nature of the modality and that they will be more effective when compared to the control group. As well as improvements in the variables of gait speed, muscle strength, balance and cognition.",[198,199],"Aged","Aged Subject",[201,202,203,204,205,206],"elderly","functionality","physical exercise","cognition","physical fragility","physical fitness","2024-10-11",{"date":209,"type":39},"2024-10-16",{"date":211,"type":22},"2025-01-01",{"date":213,"type":22},"2026-12",{"name":45,"class":46},{"id":216,"slug":217,"hasResults":11,"nctId":218,"briefTitle":219,"officialTitle":220,"acronym":4,"eligibilityCriteria":221,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":222,"targetDuration":4,"studyType":23,"phases":224,"briefSummary":225,"conditions":226,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":229,"lastUpdatePostDateStruct":230,"startDateStruct":232,"completionDateStruct":234,"leadSponsor":236,"locationsCount":47},"100525552","sinus-floor-with-osseodensification-or-lateral-window-100525552","NCT06123221","SINUS FLOOR WITH OSSEODENSIFICATION OR LATERAL WINDOW","COMPARISON OF IMPLANT INSTALLATION USING THE TRANSCRESTAL APPROACH WITH OSSEODENSIFICATION OR THE LATERAL WINDOW TECHNIQUE WITH SINUS LIFT: A RANDOMIZED CONTROLLED TRIAL.","Inclusion Criteria:\n\n* Maxillary sinuses that have residual bone height between at least 3 mm and 5 mm;\n* Width of the residual bone ridge that allows the insertion of an implant with a diameter of 4 mm;\n* Tomographic thickness of Schneider's membrane with a maximum of 5 mm in the region to be operated;\n* Residual ridge with ≥2 mm of medullary bone in the bucco-palatal direction, with a 1\u002F1 ratio of medullary and cortical bone to achieve predictable plastic expansion;\n* Patients with adequate interarch space for placement of the prosthetic crown;\n* Good physical health status (ASA1 and ASA2, according to the Physical Status Classification System - American Society of Anesthesiologists);\n* At least 6 months since the last tooth loss in the region to be operated;\n\nExclusion Criteria:\n\n* \\- Those with sinus pathology;\n* Heavy smokers (more than 10 cigarettes a day);\n* Those with a history of head and neck radiotherapy;\n* Those who have already undergone bone augmentation in any of the targeted surgical areas;\n* Immunodeficiency of any nature;\n* Emotional instability and psychiatric problems;\n* Pregnancy;\n* Current use of oral bisphosphonates or history of using injectable bisphosphonate;\n* Patients with active periodontitis defined by the presence of subgingival bleeding greater than 10%;\n* Documented allergy to drugs or dental materials involved in the experimental protocol.",{"count":223,"type":22},38,[25],"This study will compare patient-reported outcomes, as well as the type and incidence of complications, and bone marginal loss after 12 months in implants installed using the transcrestal approach (tSFE) with an osseodensification system (performed according to the protocol by Huwais et al. 2018), or installed simultaneously using the lateral window technique (lSFE) with sinus lift. A blind, randomized, controlled clinical trial will be carried out with individuals over 18 years old, and with single tooth loss in the posterior maxilla, where the residual bone height (RBH) is 3 to 5 mm. The tSFE will be performed with osseodensification burs (Densa Bur, Versah, USA) using a counterclockwise motion, associated to synthetic biomaterial (hydroxyapatite and beta-tricalcium phosphate). The lSFE technique will require the sinus to be filled with the same biomaterial as the group using the other technique, and the antrostomy to be covered with a polydioxanone-based membrane. The patient's post-operatory perceptions will be evaluated by self-administered questionnaires quantifying social and professional isolation, physical appearance, duration and changes in quality of life, eating and speech, diet variations, and sleep deficiency for 2 weeks after the procedure. Pain will be assessed with the visual analogue scale (VAS). Immediately after prosthetic rehabilitation, cone beam tomography will be performed. Controls at 6 and 12 months will be performed. In these images, the marginal bone level in relation to a fixed reference point on the implants (upper part of the platform) will be measured mesially and distally in each implant, using a specific program (ImageJ - version 1.49v \u002F NIH software - Bethesda, MD, USA). Generalized estimating equations will be used to compare the two treatments overtime. The significance level used will be 0.05.",[227,228],"Sinus Tract","Dental Implant Failed","2023-11-03",{"date":231,"type":39},"2023-11-08",{"date":233,"type":39},"2022-10-01",{"date":235,"type":22},"2026-10-01",{"name":45,"class":46},""]