[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Finis Terrae University\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":70},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,44],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100568993","high-intensity-interval-training-and-insulin-sensitivity-in-type-2-diabetes-100568993",false,"NCT06688461","High Intensity Interval Training and Insulin Sensitivity in Type 2 Diabetes","Effects of High Intensity Interval Training on Skeletal Muscle Insulin Sensitivity in Type 2 Diabetes Patients","T2D-HIIT","Inclusion Criteria:\n\n* Participants are able to provide signed and dated written informed consent prior to any study specific procedures\n* Aged ≥ 45 and ≤ 75 years\n* BMI: 25-35 kg\u002Fm2\n* Diagnosed as T2DM patients for at least 1 year and not longer than 5 years\n* HbA1c ≥ 6.5% and ≤ 8.5%\n* Fasting blood glucose \\\u003C130 mg\u002FdL\n* Women are post-menopausal (\\>1 year cessation of menses),\n* Being stable on medication use of metformin and\u002For sulfonylurea derivatives for the previous 3 months or more and other medication naïve.\n\nExclusion Criteria:\n\n* Type 1 diabetes\n* Patients with congestive heart failure and and\u002For severe renal and or liver insufficiency\n* Contraindications for MRI\u002FMRS examination\n* Active diabetic foot\n* Polyneuropathy or retinopathy\n* Signs of active liver or kidney dysfunction\n* BMI \\>35 kg\u002Fm2\n* Exogeneous insulin therapy\n* Use of antidiabetic medication other than metformin or sulfonylurea derivatives treatment within 3 months before screening\n* Use of SGLT2 inhibitors\n* Unstable body weight (variations \\>5kg in the last 3 months)\n* Ongoing weight loss diet or use of weight loss agents\n* Uncontrolled hypertension\n* Engagement in regular exercise program or any other medical condition that will impede the safe performance of the experiments","ALL","45 Years","75 Years",{"count":21,"type":22},36,"ESTIMATED","INTERVENTIONAL",[25],"NA","A recognized driver for cardiovascular complications of type 2 diabetes mellitus (T2DM) is impaired plasma glucose homeostasis as consequence of skeletal muscle insulin resistance. Insulin-mediated plasma glucose disposal in skeletal muscle comprises oxidative glucose disposal (cellular glucose uptake for oxidation) and non-oxidative glucose disposal (NOGD; cellular glucose uptake for storage as glycogen), both processes being impaired in T2DM patients. Excessive intrahepatic fat accumulation (particularly monounsaturated (MUFA) and saturated (SFA)) is commonly observed in T2DM patients and tightly associates with plasma glucose dysregulation. It has been hypothesized that skeletal muscle insulin resistance redistributes circulating glucose away from muscle which together with hyperinsulinemia promotes intrahepatic lipid accretion via de novo lipogenesis (DNL). As saturated lipids is the final product of DNL, improving skeletal muscle insulin sensitivity, next to enhance plasma glucose homeostasis, might lower intrahepatic lipid content particularly intrahepatic saturated lipids.\n\nRegular exercise is a cornerstone in the treatment of T2DM and to improve skeletal muscle insulin sensitivity. Interestingly, a conventional exercise program (aerobic-type combined with strength-type exercise) restores insulin-stimulated oxidative glucose disposal in T2DM patients to levels observed in age-matched normoglycemic subjects. Non-oxidative glucose disposal (NOGD), however, does not improve upon such conventional exercise programs. In this regard, for full restoration of compromised glucose disposal, it is pivotal to come up with effective training methods to target NOGD. High intensity interval training (HIIT) has the potential to expands the glycogen synthesis capacity in athletes by repetitive cycles of glycogen depletion\u002Frepletion, hence holds promise to improve NOGD in T2DM patients. Of note, HIIT also lowers the intrahepatic fat content in pre-diabetes individuals. Nevertheless, whether HIIT reduces the intrahepatic fat content and modifies its composition in T2DM patients is unknown. In this regard, it is hypothesized that HIIT expands the NOGD capacity in skeletal muscle of overweight\u002Fobese type 2 diabetes patients. By doing so, it is postulated that HIIT improves skeletal muscle insulin sensitivity and therefore benefits the 24 hours glycaemic profile in T2DM patients. In line, it is hypothesized that the HIIT-mediated improvements on NOGD and skeletal muscle insulin sensitivity coexist with the reduction of intrahepatic lipid content -particularly reduced saturated lipids- via lowering DNL.",[28,29,30],"Type 2 Diabetes","Lifestyle-related Condition","Insulin Sensitivity\u002FResistance","RECRUITING","2026-03-13",{"date":34,"type":35},"2026-03-16","ACTUAL",{"date":37,"type":35},"2024-10-01",{"date":39,"type":22},"2026-12-31",{"name":41,"class":42},"Finis Terrae University","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":50,"eligibilityCriteria":51,"healthyVolunteers":52,"sex":17,"minAge":53,"maxAge":54,"enrollmentInfo":55,"targetDuration":4,"studyType":23,"phases":57,"briefSummary":58,"conditions":59,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":43},"100548749","nicotinamide-riboside-supplementation-and-exercise-training-to-promote-healthy-longevity-100548749","NCT06425042","Nicotinamide Riboside Supplementation and Exercise Training to Promote Healthy Longevity","Boosting the NAD+ Levels in Older Individuals Via Nicotinamide Riboside Supplementation and Exercise Training to Promote Metabolic Health","RESTORENAD","Inclusion Criteria:\n\n* Participants are able to provide signed and dated written informed consent prior to any study specific procedures\n* Aged ≥ 60 and ≤ 80 years\n* Body mass index (BMI) 25 - 35 kg\u002Fm2\n* Stable dietary habits (no weight loss or gain \\> 5 kg in the past 3 months)\n* No signs of active cardiovascular disease, liver or kidney malfunction\n\nExclusion Criteria:\n\n* Patients with congestive heart failure and and\u002For severe renal and or liver insufficiency\n* Uncontrolled hypertension\n* Any contra-indication for MRI scanning\n* Alcohol consumption of \\> 3 servings per day for man and \\>2 servings per day for woman\n* Smoking\n* Unstable body weight (weight gain or loss \\> 5kg in the last 3 months)\n* Engagement in structured exercise activities \\> 2 hours a week\n* Previous enrolment in a clinical study with an investigational product during the last 3 months or as judged by the Investigator which would possibly hamper our study results\n* Use of food supplements containing NR or Resveratrol (similar working mechanisms)",true,"60 Years","80 Years",{"count":56,"type":22},28,[25],"The prevalence of age-related chronic diseases (like obesity, type 2 diabetes and cardiovascular diseases) is mounting worldwide, reaching pandemic proportions. These age-related chronic diseases are associated with diminished skeletal muscle mitochondrial function in humans. Nicotinamide adenosine dinucleotide (NAD) is a coenzyme that regulates mitochondrial function, therefore, plays an important role in energy metabolism. Importantly, it has been shown that high cellular NAD+ levels as well as a high NAD+\u002FNADH ratio promote metabolic and mitochondrial health. In contrast, NAD+ bioavailability declines upon aging in humans as well as in animal models of metabolic disorders and type 2 diabetes. These findings fuel the notion of boosting the NAD+ bioavailability in order to improve metabolic disturbances and mitochondrial dysfunction in aged individuals. Supplementation with nicotinamide riboside (NR), a naturally occurring form of vitamin B3, boosts cellular NAD+ levels. However, in contrast to animal studies, NR supplementation in humans has so far been unsuccessful in improving skeletal muscle mitochondrial function, exercise capacity or insulin sensitivity. Interestingly, Recently, it has been suggested that metabolic conditions where NAD+ levels become limited, is needed for NR supplementation to exert beneficial health effects. This metabolic condition could be achieved by exercise. However, studies combining NR and exercise are lacking, and that is why we will perform the present study.",[60,29,61],"Healthy Aging","Metabolic Diseases","2025-07-08",{"date":64,"type":35},"2025-07-11",{"date":66,"type":35},"2024-03-01",{"date":68,"type":22},"2026-03",{"name":41,"class":42},""]