[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Firat University\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":619},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,38,0,25,[9,46,72,104,130,151,167,193,215,235,264,287,312,339,364,385,408,431,456,481,504,531,552,578,600],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":4,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":32,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100638571","hfno-flow-rates-and-cerebral-oxygenation-during-deep-sedation-for-cystoscopy-100638571",false,"NCT07630038","HFNO Flow Rates and Cerebral Oxygenation During Deep Sedation for Cystoscopy","Effect of Different Flow Rates of High-Flow Nasal Oxygen on Peripheral and Cerebral Oxygenation and Ventilation During Procedural Sedation for Cystoscopy: A Prospective Randomized Controlled Trial","Inclusion Criteria:\n\n* Age ≥18 years\n* Scheduled to undergo elective cystoscopy under procedural sedation in an operating room setting\n* American Society of Anesthesiologists (ASA) physical status classification I-III\n* Ability to provide written informed consent\n\nExclusion Criteria:\n\n* Known neurological disorders\n* History of ischemic or hemorrhagic stroke\n* Peripheral artery disease\n* Vasculitis\n* Severe heart failure\n* Uncontrolled hypertension\n* Uncontrolled diabetes mellitus\n* Advanced-stage chronic obstructive pulmonary disease\n* Severe anemia (hemoglobin \\\u003C8 g\u002FdL)\n* Skin lesions that could interfere with near-infrared spectroscopy (NIRS) measurements\n* History of head trauma\n* History of cranial surgery\n* Nasal deformity or nasal obstruction",true,"ALL","18 Years",{"count":21,"type":22},200,"ESTIMATED","INTERVENTIONAL",[25],"NA","For Patients and Families\n\nThis study aims to investigate how high-flow oxygen therapy affects oxygen levels, especially brain oxygenation, during cystoscopy procedures performed under sedation. The goal is to improve patient safety and comfort by ensuring better oxygen delivery during the procedure. Different oxygen flow rates will be compared, while patients' breathing, oxygen levels, and vital signs are continuously monitored throughout the procedure. All methods used in the study are consistent with routine anesthesia practices, and patient safety remains the highest priority.\n\nFor Healthcare Professionals\n\nThis prospective randomized controlled study evaluates the effects of different high-flow nasal oxygen (HFNO) flow rates on cerebral oxygenation, peripheral oxygenation, and ventilation parameters in patients undergoing cystoscopy under procedural sedation. The primary aim is to determine the contribution of HFNO to sedation safety and to provide clinical evidence regarding the optimal flow rate. In addition, hypoxemia incidence, airway intervention requirements, hemodynamic variables, and sedation depth are being analyzed.",[28,29,30,31],"Deep Sedation","High Flow Nasal Canula","Cerebral Oxygenation","PSI",[29,28,33,31],"rSO2","NOT_YET_RECRUITING","2026-06-01",{"date":37,"type":38},"2026-06-05","ACTUAL",{"date":35,"type":22},{"date":41,"type":22},"2026-10-01",{"name":43,"class":44},"Firat University","OTHER",1,{"id":47,"slug":48,"hasResults":12,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":54,"enrollmentInfo":55,"targetDuration":4,"studyType":23,"phases":57,"briefSummary":58,"conditions":59,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":71},"100636210","diet-and-wb-ems-effects-in-obesity-100636210","NCT07562724","Diet and WB-EMS Effects in Obesity","Effects of Energy-Restricted Diet and Whole-Body Electromyostimulation (WB-EMS) on Myokine-Adipokine Interaction, Appetite Regulation, and Body Composition in Obese Individuals: A Randomized Controlled Trial","DEMO-OB","Inclusion Criteria:\n\n* Age between 18 and 65 years\n* Body mass index (BMI) ≥ 30 kg\u002Fm²\n* Sedentary lifestyle (less than 2 hours of structured exercise per week)\n* Willingness to participate and provide written informed consent\n\nExclusion Criteria:\n\n* Presence of pacemaker or implantable cardioverter-defibrillator\n* Known cardiovascular disease or severe chronic illness\n* Pregnancy or breastfeeding\n* Uncontrolled diabetes or severe metabolic disorders\n* Active malignancy or cancer treatment\n* Severe renal or hepatic failure\n* Acute infection or inflammatory disease\n* Orthopedic conditions limiting physical activity\n* Use of medications affecting body composition or appetite (e.g., corticosteroids, weight-loss drugs)\n* Regular resistance training within the last 3 months\n* Substance abuse, including alcohol or drug dependency\n* Psychiatric or cognitive conditions affecting adherence to the study protocol","65 Years",{"count":56,"type":22},40,[25],"Obesity is a major global health problem associated with metabolic dysfunction, altered adipokine signaling, and impaired appetite regulation. Conventional weight loss strategies such as calorie restriction often result in compensatory physiological adaptations, including increased appetite and loss of lean body mass, which may limit long-term effectiveness.\n\nWhole-body electromyostimulation (WB-EMS) is an emerging, time-efficient intervention that induces simultaneous muscle activation and may improve metabolic health. However, the underlying molecular mechanisms, particularly the interaction between myokines and adipokines, remain insufficiently understood.\n\nThis randomized controlled trial aims to investigate the effects of an energy-restricted diet combined with WB-EMS on myokine-adipokine interaction, appetite regulation, and body composition in obese individuals. Participants will be randomly assigned to either a diet-only group or a diet plus WB-EMS group for 8 weeks.\n\nPrimary outcomes include changes in serum irisin levels. Secondary outcomes include myostatin, leptin, adiponectin, FGF-21, ghrelin, GLP-1, body composition parameters, and eating behavior. The findings of this study are expected to provide novel insights into the physiological and molecular effects of WB-EMS as a complementary strategy in obesity management.",[60,61,62],"Obesity & Overweight","Metabolic Disorders","Electrotherapy","2026-05-11",{"date":65,"type":38},"2026-05-14",{"date":67,"type":22},"2026-09-01",{"date":69,"type":22},"2027-06-20",{"name":43,"class":44},2,{"id":73,"slug":74,"hasResults":12,"nctId":75,"briefTitle":76,"officialTitle":77,"acronym":78,"eligibilityCriteria":79,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":80,"enrollmentInfo":81,"targetDuration":4,"studyType":23,"phases":83,"briefSummary":84,"conditions":85,"keywords":88,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":45},"100636187","effects-of-isometric-isotonic-and-eccentric-vmo-exercises-in-patellofemoral-pain-syndrome-100636187","NCT07562425","Effects of Isometric, Isotonic, and Eccentric VMO Exercises in Patellofemoral Pain Syndrome","Comparison of the Effects of Isometric, Isotonic, and Eccentric Vastus Medialis Oblique Strengthening Exercises Applied in Terminal Knee Extension Range on Pain, Function, and Muscle Architecture in Individuals With Patellofemoral Pain Syndrome: A Randomized Controlled Trial","VMO-PFPS","Inclusion Criteria:\n\n* Aged between 18 and 40 years\n* Clinically diagnosed with patellofemoral pain syndrome\n* Presence of anterior knee pain for at least 3 months\n* Pain during activities such as stair climbing, squatting, running, or prolonged sitting\n* Pain intensity of at least 3\u002F10 on the Visual Analog Scale (VAS)\n* Willingness to participate and provide written informed consent\n\nExclusion Criteria:\n\n* History of knee trauma or surgery\n* Meniscal injury, ligament injury, or knee instability\n* Advanced osteoarthritis\n* Neurological disorders\n* Rheumatologic diseases\n* Participation in a structured knee rehabilitation program within the last 6 months\n* Pregnancy","50 Years",{"count":82,"type":22},90,[25],"Patellofemoral pain syndrome (PFPS) is a common musculoskeletal condition characterized by anterior knee pain, especially during activities such as stair climbing, squatting, running, and prolonged sitting. Weakness or delayed activation of the vastus medialis oblique (VMO) muscle is considered an important contributing factor in the development of PFPS.\n\nThis study aims to compare the effects of three different types of VMO strengthening exercises (isometric, isotonic, and eccentric) applied within the terminal knee extension range (0-30°) on pain, functional performance, and muscle architecture in individuals with PFPS.\n\nParticipants will be randomly assigned to one of three exercise groups. All participants will receive a standardized physiotherapy program, including heat therapy, TENS, and therapeutic ultrasound, followed by group-specific VMO strengthening exercises. The intervention will be performed three times per week for 8 weeks.\n\nOutcomes will be assessed before and after the intervention and will include pain intensity (Visual Analog Scale), functional performance (WOMAC, 30-second sit-to-stand test, and stair test), and muscle architecture parameters measured by ultrasound imaging.\n\nThe results of this study are expected to provide evidence for optimizing rehabilitation strategies in individuals with PFPS.",[86,87],"Patellofemoral Pain Syndrome","Anterior Knee Pain",[89,90,91,92,93,94,95],"Vastus Medialis Oblique","Knee Pain","Exercise Therapy","Isometric Exercise","Isotonic Exercise","Eccentric Exercise","Muscle Architecture","2026-05-07",{"date":98,"type":38},"2026-05-12",{"date":100,"type":22},"2026-05-20",{"date":102,"type":22},"2026-08",{"name":43,"class":44},{"id":105,"slug":106,"hasResults":12,"nctId":107,"briefTitle":108,"officialTitle":109,"acronym":110,"eligibilityCriteria":111,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":54,"enrollmentInfo":112,"targetDuration":4,"studyType":23,"phases":114,"briefSummary":115,"conditions":116,"keywords":120,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":125,"startDateStruct":126,"completionDateStruct":127,"leadSponsor":129,"locationsCount":45},"100638286","concentric-vs-eccentric-full-can-exercise-in-partial-rotator-cuff-tears-100638286","NCT07587931","Concentric vs Eccentric Full Can Exercise in Partial Rotator Cuff Tears","Comparison of the Effects of Concentric and Eccentric Full Can Exercises on Supraspinatus Muscle Architecture in Individuals With Partial Rotator Cuff Tears","FULLCAN-PRCT","Inclusion Criteria:\n\n* Aged between 18 and 65 years\n* Diagnosed with partial supraspinatus tendon tear confirmed by ultrasound or magnetic resonance imaging\n* Shoulder pain lasting at least 3 months\n* Pain intensity ≥3 on the Visual Analog Scale (VAS)\n* Willing to participate and provide informed consent\n\nExclusion Criteria:\n\n* Full-thickness rotator cuff tear\n* History of shoulder surgery\n* Shoulder instability\n* Neurological disorders\n* Rheumatological diseases\n* Corticosteroid injection within the last 3 months\n* Inability to adhere to the exercise program",{"count":113,"type":22},60,[25],"This study aims to compare the effects of concentric and eccentric full can exercises on supraspinatus muscle architecture in individuals with partial rotator cuff tears.\n\nRotator cuff tears are a common cause of shoulder pain and functional limitation. The supraspinatus muscle plays a key role in shoulder movement and stability, and its structure may be affected in individuals with partial tears.\n\nExercise-based rehabilitation is widely used in the conservative management of these conditions. The full can exercise is commonly prescribed to selectively activate the supraspinatus muscle. However, the effects of different contraction types, specifically concentric and eccentric exercises, on muscle structure and clinical outcomes are not fully understood.\n\nIn this study, participants will be randomly assigned to either a concentric or eccentric full can exercise group. Both groups will receive a standard physiotherapy program, including therapeutic ultrasound and transcutaneous electrical nerve stimulation (TENS), in addition to the assigned exercise protocol.\n\nThe intervention will last for 6 weeks, with sessions performed three times per week. Outcomes will be assessed before and after the intervention.\n\nThe primary outcome is the change in supraspinatus muscle pennation angle measured by ultrasound imaging. Secondary outcomes include muscle architecture parameters, pain intensity, range of motion, muscle strength, functional status, and kinesiophobia.\n\nThe findings of this study may help improve exercise selection in the rehabilitation of individuals with rotator cuff tears.",[117,118,119],"Partial Rotator Cuff Tears","Rotator Cuff Injuries","Shoulder Pain Syndrome",[121,122,94,123,124,95],"Supraspinatus Muscle","Full Can Exercise","Concentric Exercise","Shoulder Rehabilitation",{"date":65,"type":38},{"date":100,"type":22},{"date":128,"type":22},"2027-01-20",{"name":43,"class":44},{"id":131,"slug":132,"hasResults":12,"nctId":133,"briefTitle":134,"officialTitle":135,"acronym":4,"eligibilityCriteria":136,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":137,"enrollmentInfo":138,"targetDuration":4,"studyType":23,"phases":139,"briefSummary":140,"conditions":141,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":143,"lastUpdatePostDateStruct":144,"startDateStruct":146,"completionDateStruct":148,"leadSponsor":150,"locationsCount":45},"100632985","the-effect-of-mindfulness-based-breathing-exercises-on-dyspnea-symptom-control-and-quality-of-life-in-lung-cancer-patients-undergoing-chemotherapy-100632985","NCT07520799","The Effect of Mindfulness-Based Breathing Exercises on Dyspnea, Symptom Control, and Quality of Life in Lung Cancer Patients Undergoing Chemotherapy","The Effect of Mindfulness-Based Breathing Exercises in Lung Cancer Patients Undergoing Chemotherapy","Inclusion Criteria:\n\n* Being over 18 years of age\n* Being able to communicate adequately\n* Not having a psychiatric problem\n* Those whose physical condition preventing them from exercising has been determined by a physician\n* Patients who have completed at least 4 courses\n\nExclusion Criteria:\n\n* Individuals with communication problems\n* Individuals with psychiatric problems\n* Patients who engage in any kind of exercise\n* Will not be included in Phase 4 studies","80 Years",{"count":113,"type":22},[25],"This research is designed to determine the effect of mindfulness-based breathing exercises on dyspnea, symptom control, and quality of life in lung cancer patients undergoing chemotherapy. Lung cancer is a disease with a high mortality rate and a heavy symptom burden, and symptoms such as dyspnea, fatigue, pain, anxiety, and sleep problems are frequently observed during chemotherapy. Dyspnea, in particular, is one of the main symptoms that has both physical and emotional dimensions and significantly negatively affects patients' daily living activities, adherence to treatment, and quality of life. Therefore, integrating non-pharmacological and complementary nursing interventions into the care process in addition to pharmacological approaches is important. Mindfulness-based breathing exercises are a structured application that aims to regulate the respiratory rhythm, increase relaxation, and reduce symptom perception by enabling the individual to focus on their breath and bodily sensations without judgment. The research will be conducted using a pre-test-post-test control group experimental design. The study will be carried out with lung cancer patients receiving chemotherapy at Gazi Yaşargil Training and Research Hospital between April 2026 and September 2026. The study sample will consist of a total of 60 patients (30 experimental, 30 control) who meet the inclusion criteria and voluntarily agree to participate. Randomization will be used to determine the groups. Patients in the intervention group will receive a mindfulness-based breathing exercise program for eight weeks. The first four weeks will consist of 20-30 minute face-to-face individual training sessions once a week, followed by four weeks of 15-20 minute exercises at home twice a week. The control group will receive no intervention other than routine care. Data will be collected before and eight weeks after the intervention using a Personal Information Form, the Edmonton Symptom Assessment Scale, the EORTC QLQ-C30 Quality of Life Scale, and the Dyspnea-12 TR Scale. Frequency, percentage, mean, and standard deviation will be calculated for data analysis; chi-square test, independent samples t-test, and dependent samples t-test will be used for intergroup comparisons. This study is expected to provide evidence-based contributions to nursing care by demonstrating the effectiveness of mindfulness-based breathing exercises in reducing dyspnea and symptom burden and improving quality of life in lung cancer patients undergoing chemotherapy.",[142],"Lung Cancer","2026-04-09",{"date":145,"type":38},"2026-04-14",{"date":147,"type":22},"2026-05-01",{"date":149,"type":22},"2026-11-01",{"name":43,"class":44},{"id":152,"slug":153,"hasResults":12,"nctId":154,"briefTitle":155,"officialTitle":156,"acronym":4,"eligibilityCriteria":157,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":137,"enrollmentInfo":158,"targetDuration":4,"studyType":23,"phases":159,"briefSummary":160,"conditions":161,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":143,"lastUpdatePostDateStruct":163,"startDateStruct":164,"completionDateStruct":165,"leadSponsor":166,"locationsCount":45},"100632983","therapeutic-touch-on-sleep-comfort-and-physiological-parameters-in-intensive-care-patients-100632983","NCT07520773","Therapeutic Touch on Sleep, Comfort, and Physiological Parameters in Intensive Care Patients","The Effect of Therapeutic Touch on Sleep, Comfort, and Physiological Parameters in Intensive Care Patients: A Randomized, Placebo-Controlled Study","Inclusion Criteria:\n\n1. Adults aged 18 and over.\n2. Patients who can communicate verbally.\n3. Patients monitored in the intensive care unit for at least 3 days.\n4. Patients who can give informed consent.\n5. Hemodynamically stable patients.\n\nExclusion Criteria:\n\n1. Patients under deep sedation.\n2. Patients on mechanical ventilation.\n3. Patients with psychiatric problems.\n4. Patients with skin diseases or conditions such as open wounds, infections, or burns that would prevent therapeutic touch.\n5. Patients with excessive sedation or delirium due to sedative\u002Fanalgesic use.\n6. Patients experiencing sudden, life-threatening clinical changes during intensive care (e.g., sudden cardiac arrest or shock).",{"count":82,"type":22},[25],"Intensive care units are critical clinical areas where patients in life-threatening conditions receive care under advanced technology and continuous monitoring. In this environment, patients' sleep patterns and comfort levels are frequently disrupted, which can negatively affect physiological stability and the recovery process. The aim of this thesis proposal is to examine the effects of therapeutic touch applied to intensive care patients on sleep quality, comfort level, and physiological parameters. The research is planned as a randomized experimental study with intervention, placebo, and control groups. The study will be conducted in the Coronary Intensive Care Unit of Fırat University Hospital between April 2026 and January 2027, and a total of 90 patients meeting the research criteria will be randomized into intervention (n=30), placebo (n=30), and control (n=30) groups. The research materials consist of the Patient Identification Form, VAS-Comfort Scale, Sleep Scale, and measurements of physiological parameters (heart rate, blood pressure, body temperature, respiratory rate, oxygen saturation). The intervention group will receive therapeutic touch, the placebo group will receive superficial contact, and the control group will receive routine care. The applications will be performed daily at 8:00 PM, and comfort scale and physiological parameters will be measured before and 30 minutes after the application. Sleep quality, as an outcome variable occurring throughout the night, will be assessed the following day using the Sleep Scale. This process will be repeated for 3 days. The obtained data will be analyzed using appropriate statistical methods. In addition to descriptive statistics, One-Way Analysis of Variance (ANOVA) will be used for intergroup comparisons, and Repeated Measures ANOVA will be used to evaluate changes over time. In case of a significant difference, Bonferroni corrected post-hoc tests will be applied. If parametric assumptions are not met, appropriate non-parametric tests will be preferred. The significance level will be accepted as p\\\u003C0.05. This study aims to contribute to the development of evidence-based practices in nursing care by revealing the effects of therapeutic touch on sleep quality, comfort level, and physiological parameters of intensive care patients.",[162],"Intensive Care Patients",{"date":145,"type":38},{"date":147,"type":22},{"date":67,"type":22},{"name":43,"class":44},{"id":168,"slug":169,"hasResults":12,"nctId":170,"briefTitle":171,"officialTitle":172,"acronym":4,"eligibilityCriteria":173,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":174,"targetDuration":4,"studyType":23,"phases":176,"briefSummary":177,"conditions":178,"keywords":180,"overallStatus":184,"whyStopped":4,"lastUpdateSubmitDate":185,"lastUpdatePostDateStruct":186,"startDateStruct":188,"completionDateStruct":190,"leadSponsor":192,"locationsCount":45},"100633249","evaluation-of-the-effects-of-laughter-yoga-100633249","NCT07524231","Evaluation of the Effects of Laughter Yoga","Evaluation of the Effects of Laughter Yoga on Pain Intensity, Stress, and Beta-endorphin Levels in Patients With Multiple Sclerosis","Inclusion Criteria:\n\n* • Being over 18 years old\n\n  * Being able to communicate adequately\n  * Volunteering to participate in the research\n\nExclusion Criteria:\n\n* Unwillingness to participate in the study\n\nHaving severe cognitive impairment that prevents understanding or participation in the intervention\n\nHaving a psychiatric disorder that may affect participation in the study\n\nExperiencing an acute MS relapse during the study period\n\nHaving another serious neurological or chronic disease that may affect the study outcomes\n\nRegular participation in another complementary therapy program similar to laughter yoga\n\nCommunication problems that prevent participation in the intervention sessions",{"count":175,"type":22},72,[25],"This randomized controlled study aims to evaluate the effects of laughter yoga on pain intensity, fatigue, and beta-endorphin levels in patients with Multiple Sclerosis. Laughter yoga, a complementary therapy combining breathing exercises and laughter techniques, may help improve symptom management and psychological well-being in individuals with MS.",[179],"Multiple Sclerosis",[179,181,182,183],"pain","Laughter Yoga,","fatigue","RECRUITING","2026-04-06",{"date":187,"type":38},"2026-04-13",{"date":189,"type":38},"2026-03-10",{"date":191,"type":22},"2026-08-10",{"name":43,"class":44},{"id":194,"slug":195,"hasResults":12,"nctId":196,"briefTitle":197,"officialTitle":198,"acronym":4,"eligibilityCriteria":199,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":54,"enrollmentInfo":200,"targetDuration":4,"studyType":23,"phases":202,"briefSummary":203,"conditions":204,"keywords":207,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":210,"lastUpdatePostDateStruct":211,"startDateStruct":212,"completionDateStruct":213,"leadSponsor":214,"locationsCount":45},"100633077","impact-of-exercise-training-on-serum-glial-fibrillary-acidic-protein-gfap-brain-volumetry-and-functional-outcomes-in-multiple-sclerosis-100633077","NCT07521995","Impact of Exercise Training on Serum Glial Fibrillary Acidic Protein (GFAP), Brain Volumetry, and Functional Outcomes in Multiple Sclerosis","The Effect of an Exercise Intervention on Serum Glial Fibrillary Acidic Protein (GFAP), Brain Volumetry and and Functional Outcomes in Patients With Multiple Sclerosis: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Clinically confirmed relapsing-remitting multiple sclerosis (RRMS) diagnosis according to revised McDonald criteria (2017)\n* Mild-to-moderate disability (EDSS score 1.0-5.5)\n* No corticosteroid treatment within the previous 3 months\n\nExclusion Criteria:\n\n* Acute MS relapse within 90 days before enrollment\n* Regular participation in structured exercise programs (\\>3 hours\u002Fweek)\n* Comorbid conditions that may limit exercise participation, including significant orthopedic impairments, unstable cardiopulmonary conditions, and other systemic disorders affecting physical activity\n* Standard MRI contraindications (metallic implants, claustrophobia, etc.)\n* Concurrent neurological disorders (other than MS)\n* Initiation or modification of disease-modifying therapy within 6 months\n* Severe spasticity (Modified Ashworth Scale ≥3 in any major muscle group)",{"count":201,"type":22},30,[25],"This single-blind, randomized controlled trial will employ a two-arm parallel design (exercise group vs. control group) with a 12-week intervention period. Randomization will be implemented using SPSS 25.0 (IBM Corporation, Armonk, NY, USA) to ensure balanced group allocation. All outcome measures will be assessed at baseline and post-intervention.",[179,205,206],"Exercise","Function",[205,208,209],"Glial Fibrillary Acidic Protein","Brain Volume","2026-04-03",{"date":187,"type":38},{"date":147,"type":22},{"date":67,"type":22},{"name":43,"class":44},{"id":216,"slug":217,"hasResults":12,"nctId":218,"briefTitle":219,"officialTitle":220,"acronym":4,"eligibilityCriteria":221,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":54,"enrollmentInfo":222,"targetDuration":4,"studyType":23,"phases":224,"briefSummary":203,"conditions":225,"keywords":227,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":210,"lastUpdatePostDateStruct":229,"startDateStruct":230,"completionDateStruct":232,"leadSponsor":234,"locationsCount":45},"100632986","impact-of-exercise-training-on-serum-neurofilament-light-chain-nfl-brain-volumetry-and-functional-outcomes-in-multiple-sclerosis-100632986","NCT07520812","Impact of Exercise Training on Serum Neurofilament Light Chain (NfL), Brain Volumetry, and Functional Outcomes in Multiple Sclerosis","The Effect of an Exercise Intervention on Serum Neurofilament Light Chain and Brain Volumetry in Patients With Multiple Sclerosis: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Clinically confirmed relapsing-remitting multiple sclerosis (RRMS) diagnosis according to revised McDonald criteria (2017)\n* Mild-to-moderate disability (EDSS score 1.0-5.5)\n* No corticosteroid treatment within the previous 3 months\n\nExclusion Criteria:\n\n* Acute MS relapse within 90 days prior to enrollment\n* Regular participation in structured exercise programs (\\>3 hours\u002Fweek)\n* Comorbid conditions that may limit exercise participation, including; significant orthopedic impairments, unstable cardiopulmonary conditions and other systemic disorders affecting physical activity\n* Standard MRI contraindications (metallic implants, claustrophobia, etc.)\n* Concurrent neurological disorders (other than MS)\n* Initiation or modification of disease-modifying therapy within 6 months\n* Severe spasticity (Modified Ashworth Scale ≥3 in any major muscle group)",{"count":223,"type":22},26,[25],[179,205,226],"Neurofilament Light Chain",[205,228,209],"Neurofilament light chain",{"date":143,"type":38},{"date":231,"type":22},"2026-04-15",{"date":233,"type":22},"2026-08-15",{"name":43,"class":44},{"id":236,"slug":237,"hasResults":12,"nctId":238,"briefTitle":239,"officialTitle":240,"acronym":4,"eligibilityCriteria":241,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":54,"enrollmentInfo":242,"targetDuration":4,"studyType":23,"phases":244,"briefSummary":245,"conditions":246,"keywords":250,"overallStatus":184,"whyStopped":4,"lastUpdateSubmitDate":256,"lastUpdatePostDateStruct":257,"startDateStruct":259,"completionDateStruct":261,"leadSponsor":263,"locationsCount":45},"100628872","spsip-block-vs-sap-block-for-post-vats-pain-100628872","NCT07467291","SPSIP Block vs SAP Block for Post-VATS Pain","Comparison of Serratus Posterior Superior Intercostal Plane Block and Serratus Anterior Plane Block for Pain Management Following Video-Assisted Thoracoscopic Surgery","Inclusion Criteria:\n\n* aged 18-65 years,\n* with American Society of Anesthesiologists (ASA) physical status classification I-III,\n* Body Mass Index (BMI) \\\u003C 35 kg\u002Fm²,\n* and who read and signed the informed consent form were included.\n\nExclusion Criteria:\n\n* inability to communicate in Turkish, refusal to consent,\n* inability to use the numerical pain rating scale (NRS),\n* allergy to local anesthetics or study-specific analgesics;\n* pregnancy or breastfeeding;\n* uncontrolled anxiety or substance dependence;\n* history of thoracic surgery,\n* trauma,\n* neuromuscular or peripheral nerve disorders;\n* diabetes mellitus,\n* hepatic or renal insufficiency,\n* coagulation disorders;\n* chronic opioid or steroid use;\n* widespread pain;\n* anticoagulant therapy;\n* infection at the block application site;\n* early termination of surgery;\n* absence of planned postoperative extubation.",{"count":243,"type":22},70,[25],"Comparison of Superior Serratus Posterior Intercostal Plane Block and Serratus Anterior Plane Block for Pain Management Following Video-Assisted Thoracoscopic Surgery: A Randomized Prospective Study\n\nIntroduction Video-assisted thoracoscopic surgery (VATS) is associated with lower postoperative pain, shorter hospital stays, and better preservation of pulmonary function compared with conventional thoracotomy, owing to its minimally invasive nature. Although VATS was initially performed using a multi-port technique, it has evolved into a single-port approach, reflecting advances in surgical techniques and equipment. In Uniportal VATS, limiting surgical trauma to a single intercostal space may reduce the risk of chronic postoperative pain by decreasing intercostal nerve damage.\n\nBecause inadequate pain control after VATS may predispose patients to developing chronic post-thoracotomy pain syndrome (PTPS), effective postoperative analgesia is critically important. Therefore, regional analgesic techniques are recommended as part of multimodal analgesia. PROSPECT guidelines do not recommend the routine use of thoracic epidural analgesia for VATS, despite its effectiveness, because of its invasiveness; instead, they emphasize peripheral blocks such as paravertebral block and erector spinae plane block.\n\nAlthough not included among first-line analgesic interventions in PROSPECT guidelines, the serratus anterior plane block (SAPB) is a widely used and well-established technique in thoracic surgery. In addition, the superior serratus posterior intercostal plane block (SPSIPB) is gaining attention in VATS surgery because of its analgesic effect covering the C3-T10 dermatomes.\n\nAlthough there are studies in the literature comparing SAPB with different regional techniques, there is no randomized controlled trial directly comparing it with SPSIPB. Therefore, this planned study aimed to evaluate whether SPSIPB is noninferior to SAPB for postoperative analgesia and to compare the postoperative analgesic efficacy of the two techniques performed under ultrasound guidance.",[247,248,249],"Applying SPSIP Block With Ultrasound Guidance After VATS","Applying SAP Block With Ultrasound Guidance After VATS","Comparing the Effectiveness of Blocks Using Postoperative NRS Pain Scores",[251,252,253,254,255],"VATS","Serrratus Posterior Superior İnterfascial Plane Block","Serratus Anterior Plane Block","Postoperative Analgesia","Numeric Rating Scale","2026-03-11",{"date":258,"type":38},"2026-03-12",{"date":260,"type":38},"2026-01-20",{"date":262,"type":22},"2026-08-01",{"name":43,"class":44},{"id":265,"slug":266,"hasResults":12,"nctId":267,"briefTitle":268,"officialTitle":269,"acronym":4,"eligibilityCriteria":270,"healthyVolunteers":12,"sex":271,"minAge":19,"maxAge":4,"enrollmentInfo":272,"targetDuration":4,"studyType":23,"phases":273,"briefSummary":274,"conditions":275,"keywords":277,"overallStatus":184,"whyStopped":4,"lastUpdateSubmitDate":256,"lastUpdatePostDateStruct":282,"startDateStruct":284,"completionDateStruct":285,"leadSponsor":286,"locationsCount":45},"100629412","the-effect-of-mindfulness-based-breathing-exercises-on-symptom-control-100629412","NCT07474337","The Effect of Mindfulness-Based Breathing Exercises on Symptom Control","The Effect of Mindfulness-Based Breathing Exercises on Symptom Control and Salivary Cortisol Levels in Breast Cancer Patients Undergoing Chemotherapy","Inclusion Criteria:\n\n* Being over 18 years of age\n\n  * Knowing their diagnosis\n  * Receiving chemotherapy for the first time due to a breast cancer diagnosis\n  * Having breast cancer stages I, II, or III (stage 4 patients were not included in the study as metastatic spread would increase symptoms and make communication with the patient difficult),\n  * Not receiving treatment for another cancer,\n  * Not having a physical disability that would prevent telephone interviews (hearing, speech),\n  * Not having any psychiatric disorder that would impair comprehension and understanding,\n  * Patients who have verbally and in writing consented to participate in the study will be included in the research.\n\nExclusion Criteria:\n\n* Patients with communication problems • Patients with psychiatric problems","FEMALE",{"count":175,"type":22},[25],"This randomized controlled experimental study aims to evaluate the effect of mindfulness-based breathing exercises on symptom management and salivary cortisol levels in breast cancer patients receiving chemotherapy. The study population will consist of breast cancer patients undergoing chemotherapy treatment in the Oncology Department of Fırat University Hospital. A total of 72 patients who meet the inclusion criteria and volunteer to participate will be included in the study, with 36 patients in the experimental group and 36 in the control group. Data will be collected using the Personal Information Form and the Edmonton Symptom Assessment Scale. The findings of this study are expected to provide evidence regarding the effectiveness of mindfulness-based breathing exercises in improving symptom management and reducing stress levels in breast cancer patients receiving chemotherapy.",[276],"Breast Cancer",[278,279,280,281],"Mindfulness-Based Breathing","Symptom Management","Salivary Cortisol","Non-Pharmacological Intervention",{"date":283,"type":38},"2026-03-16",{"date":189,"type":38},{"date":233,"type":22},{"name":43,"class":44},{"id":288,"slug":289,"hasResults":12,"nctId":290,"briefTitle":291,"officialTitle":292,"acronym":4,"eligibilityCriteria":293,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":54,"enrollmentInfo":294,"targetDuration":4,"studyType":23,"phases":295,"briefSummary":296,"conditions":297,"keywords":299,"overallStatus":184,"whyStopped":4,"lastUpdateSubmitDate":305,"lastUpdatePostDateStruct":306,"startDateStruct":308,"completionDateStruct":310,"leadSponsor":311,"locationsCount":45},"100626789","comparison-of-spsip-block-and-sap-block-in-non-intubated-uniportal-vats-100626789","NCT07440199","Comparison of SPSIP Block and SAP Block in Non-Intubated Uniportal VATS.","Comparison of Serratus Posterior Superior Intercostal Plane Block and Serratus Anterior Plane Block in Uniportal Video-Assisted Thoracoscopic Surgery Without Intubation","Inclusion Criteria:\n\nThe study included patients who:\n\n* were aged 18-65 years,\n* had an American Society of Anaesthesiologists (ASA) physical status classification of I-III,\n* had a body mass index (BMI) \\\u003C 35 kg\u002Fm²,\n* read and signed the informed consent form.\n\nExclusion Criteria:\n\nPatients;\n\n* Unable to communicate in Turkish or refusing to participate in the study,\n* Unable to use the numerical pain rating scale (NRS),\n* History of allergy to local anaesthetics or analgesics used in the study,\n* Pregnant or breastfeeding,\n* History of uncontrolled anxiety disorder or substance dependence,\n* Previous thoracic surgery or history of thoracic trauma,\n* Widespread pleural adhesions detected during preoperative assessment,\n* Neuromuscular or peripheral nervous system disease,\n* Diabetes mellitus, hepatic or renal insufficiency, or coagulation disorder,\n* Chronic opioid or steroid use,\n* Widespread pain syndrome,\n* Receiving anticoagulant therapy,\n* Patients with infection detected in the area where the block will be applied were excluded.",{"count":243,"type":22},[25],"Comparison of Serratus Posterior Superior Intercostal Plane Block and Serratus Anterior Plane Block in Uniportal Video-Assisted Thoracoscopic Surgery Without Intubation Single-port video-assisted thoracoscopic surgery without intubation (NI-UniVATS) is a technique in which video-assisted thoracoscopic surgery is performed through a single port without intubating the patient. It differs significantly from traditional VATS. The literature reports that the uniportal approach provides surgical efficiency comparable to the multiportal approach, reduces postoperative pain scores, improves patient comfort due to shorter surgery, reduced chest tube use, and reduced hospital stay, and offers superior cosmetic results.\n\nBeyond the limited surgical trauma associated with single-port delivery, NI-UniVATS allows maintenance of physiological ventilation by preventing positive pressure on the lungs while preserving spontaneous breathing. This feature helps reduce postoperative pulmonary complications, especially in patients with impaired lung function. Avoiding intubation reduces the risk of local complications such as postoperative sore throat, mucosal ulceration, laryngeal or tracheal injuries, and bronchospasm due to mechanical irritation, while not using neuromuscular blocking agents eliminates curare-related complications.\n\nIn addition, the administration of hypnotic and opioid agents in limited doses supports faster recovery and reduces the frequency of postoperative sedation, nausea, and vomiting. Consistent with these physiological and pharmacological advantages, NIVATS stands out as an effective, patient-centered surgical approach associated with shorter hospital stays and accelerated recovery.\n\nIn the transition from aggressive surgical approaches to minimally invasive methods for treating pleural, mediastinal, and pulmonary diseases, advancements in surgical techniques and progress in anesthesia have played a decisive role. In video-assisted thoracoscopic surgery (NI-VATS), which does not require intubation, the safe performance of the procedure requires the use of appropriate anesthetic techniques to protect patients from severe hypoxia and hypercapnia, to effectively control pain during surgical resection, and to suppress the cough reflex so that the lung can be manipulated more stably and safely.\n\nAdequate and effective analgesia is a fundamental requirement for the success of this approach. Although thoracic epidural anesthesia and paravertebral blocks provide effective analgesia, facial plane blocks such as the serratus anterior plane block, rhomboid intercostal block, and erector spinae plane block can be used alone or in combination as the primary anesthetic method in NI-VATS procedures because of their ease of application and relatively low risk of complications.\n\nThe serratus posterior superior intercostal plane block (SPSIPB), described by Tulgar et al. in 2023, has been reported to provide effective analgesia in the anterolateral hemithorax, including the C3-T10 dermatomes. Consistent with these findings, it is increasingly used for postoperative analgesia in VATS surgery. In addition, one case reports successful NI-VATS without complications after SPSIPB application. Given these features, SPSIPB has the potential to be an effective anesthetic and analgesic option in NI-VATS patients.\n\nIn light of this data, identifying an effective, safe, and easily applicable regional analgesic technique for NI-VATS procedures is clinically important. Evidence comparing the efficacy of SPSIPB, a technique recently described and gaining increasing attention in thoracic surgery, with SAPB, a facial plane block commonly used in NI-VATS procedures, is limited. The aim of this study is to evaluate the perioperative anesthetic and analgesic efficacy of ultrasound-guided SPSIPB in patients undergoing NI-VATS, compared with SAPB. The hypothesis of this study is that the serratus posterior superior intercostal plane block is non-inferior to the serratus anterior plane block in terms of intraoperative anesthetic requirements, pain control, and perioperative analgesic requirements.\n\nMaterials and Methodology Study Design and Patient Selection This study was designed as a single-center, prospective, randomized, double-blind trial. The study protocol was approved by the Ethics Committee for Clinical Research at Fırat University Faculty of Medicine (Approval No: 2023-181). After approval, a total of 70 patients scheduled to undergo elective non-intubated uniportal video-assisted thoracoscopic surgery (NI-UniVATS) were included in the study. The research was conducted between 20 January 2026 and 15 August 2026.\n\nInclusion Criteria\n\nThe study included patients who:\n\n* were aged 18-65 years,\n* had an American Society of Anaesthesiologists (ASA) physical status classification of I-III,\n* had a body mass index (BMI) \\\u003C 35 kg\u002Fm²,\n* read and signed the informed consent form. Exclusion Criteria",[298],"This Study Evaluates the Effects of Different Fascial Plane Blocks on Intraoperative Anesthesia and Analgesic Consumption in Non-intubated VATS Procedures",[300,301,302,303,304],"NIVATS","Bullectomy","pleural biopsy","Serratus Posterior Superior Intercostal Block","Serratus Anterior Plan Block","2026-02-23",{"date":307,"type":38},"2026-02-27",{"date":309,"type":38},"2026-01-16",{"date":233,"type":22},{"name":43,"class":44},{"id":313,"slug":314,"hasResults":12,"nctId":315,"briefTitle":316,"officialTitle":317,"acronym":4,"eligibilityCriteria":318,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":319,"enrollmentInfo":320,"targetDuration":4,"studyType":23,"phases":322,"briefSummary":323,"conditions":324,"keywords":329,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":332,"lastUpdatePostDateStruct":333,"startDateStruct":335,"completionDateStruct":336,"leadSponsor":338,"locationsCount":4},"100597823","fake-coughing-during-bone-marrow-aspiration-and-biopsy-100597823","NCT07063498","Fake Coughing During Bone Marrow Aspiration and Biopsy","The Effect of Fake Coughing and Stress Ball Application on Pain During Bone Marrow Aspiration and Biopsy","Inclusion Criteria:\n\n* Diagnosed with cancer at least 3 months ago\n* Over 18 years of age\n* Able to communicate adequately\n* No psychiatric problems\n* Willing to participate in the study\n\nExclusion Criteria:\n\n* Patients with communication problems\n* Patients with psychiatric problems","75 Years",{"count":321,"type":22},80,[25],"Hematology patients go through many difficult periods during the diagnosis process. One of the most commonly used methods in the diagnosis of hematological diseases is bone marrow aspiration and biopsy (BMAB). BMAB is an invasive procedure and may cause pain in patients. For this purpose, a local anesthetic agent is used during the procedure. However, no effective method has been developed to prevent pain in patients. Both pharmacological and non-pharmacological methods are used to manage pain. Among non-pharmacological methods, cognitive distraction techniques such as feigned coughing and stress balls are used to reduce pain and stress. Some studies have reported that \"fake coughing\" reduces pain during procedures that cause temporary, sharp pain, such as parenteral injections or venipuncture. A literature review revealed that patients undergoing bone marrow aspiration and biopsy experience intense stress and pain, but there are insufficient studies examining these concepts. This study is expected to contribute to the nursing literature. The aim of this study is to determine the effect of fake coughing and stress ball application on pain during bone marrow aspiration and biopsy.",[325,326,327,328],"Bone Marrow Aspiration and Biopsy","Pain","Feigned Cough","Stress Ball",[330,326,331],"bone marrow aspiration and biopsy","Stress","2026-01-22",{"date":334,"type":38},"2026-01-23",{"date":332,"type":22},{"date":337,"type":22},"2026-09-20",{"name":43,"class":44},{"id":340,"slug":341,"hasResults":12,"nctId":342,"briefTitle":343,"officialTitle":344,"acronym":4,"eligibilityCriteria":345,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":319,"enrollmentInfo":346,"targetDuration":4,"studyType":23,"phases":347,"briefSummary":348,"conditions":349,"keywords":351,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":356,"lastUpdatePostDateStruct":357,"startDateStruct":359,"completionDateStruct":361,"leadSponsor":363,"locationsCount":45},"100597657","the-effect-of-therapeutic-touch-on-agitation-pain-and-cortisol-levels-in-intensive-care-patients-100597657","NCT07061340","The Effect of Therapeutic Touch on Agitation, Pain, and Cortisol Levels in Intensive Care Patients","The Effect of Therapeutic Touch on Agitation, Pain, and Cortisol Levels in Intensive Care Patients: A Randomized Controlled Study","Inclusion Criteria:\n\n* Adults aged 18 years and above.\n* Patients who can communicate verbally.\n* Patients who have been monitored in the intensive care unit for at least 4 days.\n* Patients who are able to give informed consent.\n* Patients who are hemodynamically stable.\n* Richmond Agitation-Sedation Scale 1 and above.\n* Visual Analog Scale 1 and above.\n\nExclusion Criteria:\n\n1. Patients under deep sedation.\n2. Patients on mechanical ventilation.\n3. Patients with psychiatric problems.\n4. Patients with skin diseases or open wounds, infections, burns that would prevent therapeutic touch.\n5. Patients using sedative\u002Fanalgesic drugs (excessive sedation or delirium).\n6. Patients using corticosteroids or drugs that affect adrenal hormone levels (because these drugs can affect cortisol measurements).\n7. Patients who have sudden life-threatening clinical changes during intensive care (e.g. sudden cardiac arrest, shock).",{"count":113,"type":22},[25],"Intensive care units (ICU) are special clinical areas where advanced monitoring and treatment of patients with life-threatening organ failure or those at risk of developing organ failure are carried out, with high technological equipment and a multidisciplinary approach is adopted. Agitation, pain, anxiety and hormonal imbalances are frequently observed due to hospitalization in ICU. In this stressful environment, patients often experience pain and agitation. Both situations trigger a physiological stress response in the patient and increase cortisol secretion. This increase in cortisol levels can suppress the immune system, delay wound healing and negatively affect the patient's general prognosis. Today, in addition to modern medicine, complementary\u002Falternative therapies are increasingly used. One of these alternative therapies is therapeutic touch application. Therapeutic touch is based on the therapeutic effect of the act of touching. Therapeutic touch, alternatively known as healing touch, is a complementary\u002Falternative treatment method applied by touching energy points on the body. Therefore, this study was planned to examine the effects of therapeutic touch applied to patients in intensive care on pain, agitation and cortisol levels. This study, planned as a randomized experimental study with a pre-test-post-test intervention control group, will consist of patients in the Intensive Care Unit of Fırat University Hospital. The sample will consist of 60 intensive care patients, 30 in the intervention group and 30 in the control group, who meet the research criteria on the specified dates and accept the research. The patients in the intervention and control groups will first be informed about the application before starting the application and their verbal and written consents will be obtained. Then, the intervention group will be given the Patient Identification Form, Richmond Agitation-Sedation Scale (RASS), Visual Analog Scale (VAS), cortisol levels from laboratory data will be recorded and therapeutic touch will be applied and after the application, the RASS and VAS scales will be filled again and the blood cortisol levels will be checked. This process will be done before and after each application and a total of 8 measurements will be taken. The application will take approximately 15-30 minutes every four days for the patients in the intervention group. During this period, no application will be made to the patients in the control group and RASS, VAS scales will be filled every four days and blood cortisol levels will be checked. Thus, a total of 8 measurements will be obtained. In the analysis of the data; frequency and percentage analyses, chi-square analysis, standard deviation, t-test in dependent groups, t-test analysis in independent groups will be performed.",[350],"Therapeutic Touch",[350,352,326,353,354,355],"İntensive Care","Agitation","Cortisol","Nursing","2025-11-14",{"date":358,"type":38},"2025-11-17",{"date":360,"type":22},"2025-12-31",{"date":362,"type":22},"2026-07-01",{"name":43,"class":44},{"id":365,"slug":366,"hasResults":12,"nctId":367,"briefTitle":368,"officialTitle":369,"acronym":4,"eligibilityCriteria":370,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":319,"enrollmentInfo":371,"targetDuration":4,"studyType":23,"phases":372,"briefSummary":373,"conditions":374,"keywords":376,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":356,"lastUpdatePostDateStruct":380,"startDateStruct":382,"completionDateStruct":383,"leadSponsor":384,"locationsCount":45},"100597658","effect-of-therapeutic-touch-on-perceived-stress-and-comfort-levels-in-hemodialysis-patients-100597658","NCT07061353","Effect of Therapeutic Touch on Perceived Stress and Comfort Levels in Hemodialysis Patients","Effect of Therapeutic Touch on Perceived Stress and Comfort Levels in Hemodialysis Patients: A Randomized Controlled Trial","Inclusion Criteria:\n\n* At least 3 months of hemodialysis treatment • Cognitive function is in place\n\nExclusion Criteria:\n\n* Those with communication problems\n* Those who do not agree to participate in the study\n* Patients who receive traditional treatment for the disease",{"count":113,"type":22},[25],"Hemodialysis is a treatment method used in the treatment of acute or chronic renal failure, the main function of which is based on the cleaning of accumulated waste materials in the blood, and is rapidly developing and spreading in parallel with today's technology. Patients undergoing hemodialysis treatment are trying to cope with social and physical problems that may develop due to chronic disease. At the same time, their quality of life is affected due to the psychosocial, economic problems and complications brought about by machine dependency. From past to present, individuals have used various methods to protect\u002Fimprove their health. Today, in addition to modern medicine, complementary\u002Falternative therapies are increasingly used. One of these alternative therapies is the therapeutic touch application, which has recently gained popularity. Therapeutic touch is based on the therapeutic effect of the act of touching. Therapeutic touch, alternatively known as healing touch, is a complementary\u002Falternative treatment method applied by touching energy points in the body. Therefore, this study was planned to examine the effect of therapeutic touch applied to hemodialysis patients on perceived stress and comfort levels. This study, planned as a randomized experimental study with a pre-test-post-test intervention control group, will be a study on dialysis patients receiving treatment at the hemodialysis unit of Fırat University Hospital between June 2025-June 2026. The sample will consist of a minimum of 60 dialysis patients (30 intervention, 30 control) who meet the research criteria and accept the study. The patients in the intervention and control groups will first be informed about the application before starting the application and their verbal and written consents will be obtained. Then, the Patient Identification Form, Visual Analog Scale-Comfort (VAS-Comfort), Hemodialysis Comfort Scale (HKS) and Perceived Stress Scale (PSS) will be applied and the 1st measurement will be obtained. The application will last approximately 15-30 minutes for the patients in the intervention group every three days. After three days of alternate application, data forms will be filled in again for patients and 2nd measurements will be obtained. During this period, no intervention will be made to patients in the control group and only the normal treatment protocol will be applied. At the end of three days, data forms will be filled in again and 2nd measurements will be obtained. In the analysis of data; frequency and percentage analyses, chi-square analysis, standard deviation, t-test in dependent groups, t-test analysis in independent groups will be performed.",[350,375],"Hemodialysis Patients",[377,378,331,379,355],"Therapeutic touch","Hemodialysis Patient","Comfort",{"date":381,"type":38},"2025-11-18",{"date":360,"type":22},{"date":35,"type":22},{"name":43,"class":44},{"id":386,"slug":387,"hasResults":12,"nctId":388,"briefTitle":389,"officialTitle":389,"acronym":4,"eligibilityCriteria":390,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":80,"enrollmentInfo":391,"targetDuration":4,"studyType":393,"phases":4,"briefSummary":394,"conditions":395,"keywords":398,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":400,"lastUpdatePostDateStruct":401,"startDateStruct":403,"completionDateStruct":405,"leadSponsor":407,"locationsCount":4},"100608482","investigation-of-the-relationship-between-upper-extremity-function-in-string-instrument-performers-and-shoulder-proprioception-posture-hypermobility-and-performance-anxiety-100608482","NCT07202130","Investigation of The Relationship Between Upper Extremity Function in String Instrument Performers and Shoulder Proprioception, Posture, Hypermobility and Performance Anxiety","Inclusion Criteria:\n\n* Be aged between 18 and 50\n* Not play any musical instrument\n* Be a sedentary individual (individuals without regular exercise habits)\n\nExclusion Criteria:\n\n* Being pregnant\n* Having undergone surgery involving the shoulder, arm, forearm or hand region within the last 6 months\n* Having any psychological diagnosis or regularly taking antidepressant medication\n* Having any chronic illness that could affect upper limb function",{"count":392,"type":22},68,"OBSERVATIONAL","Work-related musculoskeletal problems are seen in many professions, including musicians. Musculoskeletal problems related to playing are defined as any weakness, numbness, pain, tingling, or other symptoms that affect a musician's ability to play a musical instrument at their usual level. Given the high workload on the upper extremities, it is likely that neurological and musculoskeletal changes and\u002For dysfunctions are more common in musicians. Prolonged static activity and overuse of the trunk and proximal upper extremity muscles in musicians also frequently affect upper extremity function. Nerve compression syndromes affecting the median and ulnar nerves or thoracic outlet affect many musicians. Focal dystonias seen in musicians can affect the muscles that make up part or all of one hand. Studies evaluating musculoskeletal problems and upper extremity function in instrumentalists are limited in the literature. The aim of our study is to investigate the factors affecting upper extremity function in stringed instrument performers within a group of musicians, to compare them with a group that does not play any musical instrument, and to contribute the results to the literature. A total of 68 participants will be included in the study on a voluntary basis, comprising a stringed instrument performer group (n=34) and a control group not playing any musical instrument (n=34). Upper extremity function will be assessed using the Health Throw Test, the Disability of the Arm, Shoulder, and Hand (DASH) Questionnaire and hand dynamometer, musculoskeletal system with the Nordic Musculoskeletal System Questionnaire, performance anxiety with the Kenny Music Performance Anxiety Inventory, pain with the Visual Analogue Scale (VAS), hypermobility with the Beighton Scoring System for Hypermobility and the Upper Extremity Hypermobility Questionnaire, reaction time with the Nelson Hand Reaction Test, coordination using the Touching Discs Test, posture using the Apecs-AI Posture Assessment and Correction System® (Apecs) application, shoulder proprioception using a goniometer, upper extremity balance using the Y Balance Test, and shoulder girdle endurance and stabilisation using the Closed Kinetic Chain Upper Extremity Stability Test.",[396,397],"Upper Extremity Function","Shoulder Proprioception",[399],"Hypermobility, Performance Anxiety, Shoulder Proprioception, Stringed Instrument Performer, Upper Extremity Function","2025-09-23",{"date":402,"type":38},"2025-10-01",{"date":404,"type":22},"2025-09-25",{"date":406,"type":22},"2026-02-05",{"name":43,"class":44},{"id":409,"slug":410,"hasResults":12,"nctId":411,"briefTitle":412,"officialTitle":413,"acronym":4,"eligibilityCriteria":414,"healthyVolunteers":12,"sex":271,"minAge":19,"maxAge":54,"enrollmentInfo":415,"targetDuration":4,"studyType":393,"phases":4,"briefSummary":416,"conditions":417,"keywords":419,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":424,"lastUpdatePostDateStruct":425,"startDateStruct":427,"completionDateStruct":428,"leadSponsor":430,"locationsCount":45},"100606982","investigation-of-the-effects-of-anti-tnf--and-non-tnf--drugs-n-patients-with-rheumatoid-arthritis-100606982","NCT07182630","Investigation Of The Effects Of Anti-Tnf-Α And Non-Tnf-Α Drugs İn Patients With Rheumatoid Arthritis","Investigation Of The Effects Of Anti-Tnf-Α And Non-Tnf-Α Drugs On Aerobic Capacity, Muscle Strength, Fatigue, Cardiovascular Disease Risk Factors, And Disease Activity İn Patients With Rheumatoid Arthritis","Inclusion Criteria:\n\n* Diagnosed with RA according to the 2010 American College of Rheumatology (ACR-2010) criteria\n* Be between 18 and 65 years of age\n* Be literate\n* Have been using one of the anti-TNF-α or non-TNF-α drugs for a period of 1-3 years\n\nExclusion Criteria:\n\n* Being pregnant or having a diagnosis of malignancy\n* Having a dysfunction that would limit physical activity (cycling for aerobic capacity assessment), such as severe neurological involvement, immobility, or incooperation\n* Having a regular exercise habit (reporting a habit of exercising 3 or more days per week)\n* Having another chronic disease\n* Having cardiac symptoms according to the New York Heart Association\n* Having mental problems that prevent participation in assessments",{"count":56,"type":22},"In RA, joint structure is damaged due to destructive inflammation in the synovium. This condition negatively affects the patient's level of physical activity. As the patient becomes more immobile, their muscle mass and strength decrease and their aerobic capacity declines. One of the drug groups used in the pharmacological treatment of RA is anti-TNF-α drugs. The aim of this study is to investigate the effects of anti-TNF-α and non-TNF-α drug treatments on aerobic capacity, muscle strength, fatigue, cardiorespiratory risk factors, and disease activity in RA patients.",[418],"Rheumatoid Arthritis (RA",[420,421,422,423],"Anti TNF-α","Non TNF-α","Rheumatoid arthritis","Aerobic Capacity","2025-09-18",{"date":426,"type":38},"2025-09-19",{"date":402,"type":22},{"date":429,"type":22},"2026-01-30",{"name":43,"class":44},{"id":432,"slug":433,"hasResults":12,"nctId":434,"briefTitle":435,"officialTitle":436,"acronym":4,"eligibilityCriteria":437,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":319,"enrollmentInfo":438,"targetDuration":4,"studyType":23,"phases":440,"briefSummary":441,"conditions":442,"keywords":443,"overallStatus":184,"whyStopped":4,"lastUpdateSubmitDate":448,"lastUpdatePostDateStruct":449,"startDateStruct":451,"completionDateStruct":453,"leadSponsor":455,"locationsCount":45},"100599389","effects-of-reiki-and-self-acupressure-applications-100599389","NCT07083856","Effects of Reiki and Self-Acupressure Applications","Comparison of the Effects of Reiki and Self-Acupressure Applications on Functionality and Quality of Life in Patients With Multiple Sclerosis: A Randomized Controlled Trial","Inclusion Criteria:\n\n1. Patients who are willing to participate\n2. Patients who have no communication problems\n3. Patients who are 18 years of age or older\n4. Patients who live in the center\n5. Patients who have no scratches or deformities in the treatment area\n6. Patients who do not smoke, use drugs, or use tranquilizers, and are not pregnant\n7. Patients who have been receiving MS treatment for more than three months\n\nExclusion Criteria:\n\n1. Patients who smoke, use substances, or use tranquilizers\n2. Have dyspnea\n3. Have anemia\n4. Have diabetes\n5. Have received corticosteroid treatment in the last three months\n6. Have had an MS attack in the last three months\n7. Have an autoimmune disease other than multiple sclerosis\n8. Have signs of infection\n9. Have a thyroid problem\n10. Are taking psychostimulant medications\n11. Have anxiety or depression detected in outpatient clinic screenings\n12. Refuse to participate in the study\n13. Have another known neurological system disease (dementia, Alzheimer's, etc.)\n14. Have a communication barrier will not be included in the study.",{"count":439,"type":22},50,[25],"Reiki, the subject of our research, is a complementary medicine practice within energy approaches. Discovered in Sanskrit texts by Dr. Usui in Japan in the late 19th century, it was demonstrated through studies demonstrating its effectiveness in symptoms of pain, depression, insomnia, and fatigue. Everything in the universe, including the human body, is composed of energy; any disruption in this energy can lead to illness. There are seven chakras where Reiki is applied. The main chakra centers are located along the spine. During Reiki treatments, the hands are held in each position, touching the head, neck, chest, abdominal cavity, and groin for 3-5 minutes. This period may extend to 10-20 minutes in problematic areas. The average treatment duration is 30-90 minutes. During the treatment, the patient lies down or reclines, and there is no need to remove clothing. During Reiki treatment, individuals may report a slight warming sensation under or near the therapist's hand. The only rule in Reiki practice is that the individual gives the practitioner permission to facilitate the flow of energy. The person receiving Reiki does not need to believe in Reiki during the treatment. Reiki is a universal life energy present in everyone. Reiki is generally safe, and no serious side effects have been reported. Over the last 10 years, Reiki practice has been increasing among physicians, nurses, and other healthcare professionals. This study will compare the effects of acupressure and Reiki treatments on functionality and quality of life in patients with multiple sclerosis.",[179],[444,445,446,447],"Reiki","Self-Acupressure","Functionality","Quality of Life","2025-07-17",{"date":450,"type":38},"2025-07-24",{"date":452,"type":38},"2025-04-20",{"date":454,"type":22},"2025-09-20",{"name":43,"class":44},{"id":457,"slug":458,"hasResults":12,"nctId":459,"briefTitle":460,"officialTitle":460,"acronym":4,"eligibilityCriteria":461,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":462,"targetDuration":4,"studyType":23,"phases":463,"briefSummary":464,"conditions":465,"keywords":468,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":473,"lastUpdatePostDateStruct":474,"startDateStruct":476,"completionDateStruct":478,"leadSponsor":480,"locationsCount":4},"100596486","effects-of-a-20-minute-mindfulness-based-breathing-exercise-on-dyspnea-fatigue-and-sleep-quality-in-patients-with-heart-failure-100596486","NCT07046091","Effects of a 20-Minute Mindfulness-Based Breathing Exercise on Dyspnea, Fatigue, and Sleep Quality in Patients With Heart Failure","Inclusion Criteria\n\n* Over 18 years of age\n* Able to communicate effectively\n* No psychiatric disorders Exclusion Criteria\n* Patients with communication problems\n* Patients with psychiatric disorders",{"count":175,"type":22},[25],"Heart failure (HF) is a chronic condition that leads to incapacity. Despite significant progress in optimizing pharmacological treatment for HF patients, the personal and social burden of this disease is still characterized by debilitating symptoms and rehospitalizations. Today, many patients with heart failure use non-pharmacological methods for managing common symptoms. Due to the increased interest in non-pharmacological methods among individuals in society, it has become essential for healthcare professionals, including nurses as part of the healthcare team, to play a role in these methods to meet the health needs of the community.\n\nOne of the interventions nurses can offer for symptom management is mindfulness-based breathing exercises. In this mind-body-based practice, attention is focused on the breath, helping individuals develop awareness of their negative thoughts and emotions.\n\nThe study population will consist of patients admitted to the Cardiology Department of Firat University Hospital. The sample size was determined by a power analysis, with a 0.05 margin of error, a 0.95 confidence interval, and a 0.5 effect size, representing 80% of the population, resulting in 72 patients for both the experimental and control groups. Data collection tools for the study will include a Personal Information Form, the Dyspnea-12 Scale, the Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F) Scale, and the Richard-Campbell Sleep Scale. SPSS (Statistical Programme for Social Sciences) software will be used to analyze the data obtained from the study.\n\nThe aim of this study is to determine the effects of a 20-minute mindfulness-based breathing exercise on dyspnea, fatigue, and sleep quality in patients with heart failure.",[466,467],"Heart Failure","Heart Failure - NYHA II - IV",[469,470,471,183,472],"heart failure","mindfulness","dsypnea","sleep quality","2025-06-23",{"date":475,"type":38},"2025-07-01",{"date":477,"type":22},"2025-08-15",{"date":479,"type":22},"2026-06-20",{"name":43,"class":44},{"id":482,"slug":483,"hasResults":12,"nctId":484,"briefTitle":485,"officialTitle":486,"acronym":4,"eligibilityCriteria":487,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":137,"enrollmentInfo":488,"targetDuration":4,"studyType":23,"phases":489,"briefSummary":490,"conditions":491,"keywords":493,"overallStatus":184,"whyStopped":4,"lastUpdateSubmitDate":496,"lastUpdatePostDateStruct":497,"startDateStruct":499,"completionDateStruct":501,"leadSponsor":503,"locationsCount":45},"100559578","the-effect-of-carer-training-on-pressure-ulcers-in-palliative-patients-100559578","NCT06565949","The Effect of Carer Training on Pressure Ulcers in Palliative Patients","The Effect of Carer Training on Pressure Ulcers in Palliative Care Patients","Inclusion Criteria:\n\n* Over 18 years of age\n* Being the sole informal caregiver of the palliative care patient\n* Being able to use physical abilities such as sight and hearing\n* No cognitive and communication problems\n\nExclusion Criteria:\n\n* Palliative care patient is not the only informal caregiver\n* Cognitive and communication problems",{"count":175,"type":22},[25],"The aim of this article is to examine the effect of the training of carers caring for palliative care patients on the prevention and management of pressure ulcers. In this context, how the training affects the level of knowledge and practices of the carers will be evaluated. The findings obtained will contribute to improving the quality of patient care by providing strategic recommendations for the improvement of palliative care services.",[492],"Public Health Nursing",[494,495],"Palliative Care","Pressure Ulcers","2025-03-11",{"date":498,"type":38},"2025-03-12",{"date":500,"type":38},"2024-07-25",{"date":502,"type":22},"2025-09-15",{"name":43,"class":44},{"id":505,"slug":506,"hasResults":12,"nctId":507,"briefTitle":508,"officialTitle":509,"acronym":4,"eligibilityCriteria":510,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":511,"targetDuration":4,"studyType":23,"phases":513,"briefSummary":514,"conditions":515,"keywords":519,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":524,"lastUpdatePostDateStruct":525,"startDateStruct":527,"completionDateStruct":528,"leadSponsor":530,"locationsCount":45},"100582150","chester-step-test-is-it-effective-in-scleroderma-patients-100582150","NCT06859567","Chester Step Test: is It Effective in Scleroderma Patients?","Proving the Efficacy of the Chester Step Test in Scleroderma Patients Compared with the 6-Minute Walk Test","Inclusion Criteria:\n\n* Over 18 years old\n* Patients who can walk independently without an assistive device\n\nExclusion Criteria:\n\n* Chronic obstructive pulmonary disease\n* Myocardial infarction history\n* Congestive heart failure\n* Serious or unstable illness that may limit exercise tolerance\n* Presence of severe musculoskeletal and joint disorders that may interfere with the conduct of the test\n* Inability to perform the simplest level of the Chester step test\n* Arthroplasty or major operations on knee and hip joints\n* Uncontrolled hypertension\n* Lack of ability to understand and implement all recommended procedures",{"count":512,"type":22},45,[25],"Systemic sclerosis (SSC) is a chronic autoimmune disease in which autoimmune features are associated with vascular manifestations. Patients with SSC experience many problems such as interstitial lung disease (ILD), pulmonary arterial hypertension (PAH), heart failure, severe gastrointestinal tract (GIT) involvement and scleroderma renal crisis (SRC). Because of these problems, SSC patients may develop an abnormal pulmonary hemodynamic response during exercise. In this situation, measuring the aerobic capacity of SSC patients can be a useful tool for health promotion. There are many different methods for measuring aerobic capacity tests. The most commonly used aerobic capacity test in SSC patients is the 6-minute walk test (6 MWT). However, although the 6 MWT is a commonly used test, it has some disadvantages. Because SSC affects multiple organs, there are doubts about the 6 MWT's ability to accurately assess these diseases. These disadvantages of the 6MWT have led to the search for new tests. The Chester step test (CST) is a submaximal test and a good option to assess aerobic capacity. An adapted version of the CST for non-healthy individuals can be used to assess aerobic capacity. There are some studies conducted with CST. As a result of my research, no study evaluating CST in individuals with SSC was found.",[516,517,518],"Systemic Sclerosis (SSc)","Chester Step Test","6 Minutes Walk Test",[520,521,522,523],"Chester step test","Systemic Sclerosis","6 minutes walk test","Modified Borg Scale","2025-02-28",{"date":526,"type":38},"2025-03-05",{"date":496,"type":22},{"date":529,"type":22},"2025-07-15",{"name":43,"class":44},{"id":532,"slug":533,"hasResults":12,"nctId":534,"briefTitle":535,"officialTitle":535,"acronym":4,"eligibilityCriteria":536,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":54,"enrollmentInfo":537,"targetDuration":4,"studyType":393,"phases":4,"briefSummary":538,"conditions":539,"keywords":541,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":545,"lastUpdatePostDateStruct":546,"startDateStruct":548,"completionDateStruct":549,"leadSponsor":551,"locationsCount":4},"100581993","the-relationship-of-hand-sensory-and-strength-assessments-with-functionality-and-kinesiophobia-in-individuals-with-rheumatoid-arthritis-100581993","NCT06857526","The Relationship of Hand Sensory and Strength Assessments with Functionality and Kinesiophobia in Individuals with Rheumatoid Arthritis","Inclusion Criteria:\n\n* Female patients between 18-65 years of age\n* Patients whose medical treatment has been stable for the last 3 months\n\nExclusion Criteria:\n\n* Patients who have undergone surgery on the hand and wrist\n* Patients with prosthesis\n* Patients with neurological or orthopedic diseases\n* Patients with another accompanying rheumatic disease\n* Patients with malignancy\n* Pregnant patients",{"count":439,"type":22},"Rheumatoid arthritis (RA) is a systemic inflammatory disease that can involve all tissues with synovium. The wrist and hand, which are of great importance in our daily activities, are involved early and specifically because they are rich in synovium, which is the target tissue in RA.In many patients with rheumatoid arthritis, hand and wrist involvement is seen from the early stages of the disease. Pain, stiffness and swelling in the joint are accompanied by decreased range of motion and muscle strength.Hand functions have a very important place due to the fact that the hand must be used in countless daily life activities.Kinesiophobia is defined as a state of fear and avoidance of activity and physical movement caused by painful injury and sensitivity to repeated injury.The aim of this study was to investigate the relationship between hand sensory and strength assessment, functionality and kinesiophobia in individuals with rheumatoid arthritis.",[540],"Disease",[542,543,544],"hand force assessment","hand sensory evaluation","romatoid artrit","2025-02-26",{"date":547,"type":38},"2025-03-04",{"date":526,"type":22},{"date":550,"type":22},"2025-06-05",{"name":43,"class":44},{"id":553,"slug":554,"hasResults":12,"nctId":555,"briefTitle":556,"officialTitle":557,"acronym":4,"eligibilityCriteria":558,"healthyVolunteers":17,"sex":18,"minAge":559,"maxAge":560,"enrollmentInfo":561,"targetDuration":4,"studyType":393,"phases":4,"briefSummary":563,"conditions":564,"keywords":569,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":545,"lastUpdatePostDateStruct":571,"startDateStruct":573,"completionDateStruct":575,"leadSponsor":577,"locationsCount":45},"100581744","comparison-of-the-impact-of-physical-activity-attitude-between-different-department-university-students-100581744","NCT06854289","Comparison of the Impact of Physical Activity Attitude Between Different Department University Students","Comparison of the Impact of Physical Activity Attitude on Physical Activity Level and Postural Awareness Between Physiotherapy and Rehabilitation Department Students and Software Engineering Department Students","Inclusion Criteria:\n\n* Physiotherapy and Rehabilitation department or software engineering department is progressing in the 3rd or 4th year undergraduate degree\n\nExclusion Criteria:\n\n* Having any chronic disease that prevents regular physical activity\n* Having a congenital or acquired disease that causes postural disorders and\u002For having received postural treatment.","20 Years","25 Years",{"count":562,"type":22},300,"In recent years, the level of physical activity among university students has been steadily decreasing, and young people are leading a sedentary lifestyle. The aim of this study is to evaluate and compare the perspectives and attitudes towards physical activity of students from the Physiotherapy and Rehabilitation department, who are expected to have awareness of physical activity due to their undergraduate education, with students from the Software Engineering department, who do not receive education on this subject. The study will also investigate how these perspectives and attitudes affect their level of physical activity and postural awareness.Software Engineering students and Physiotherapy and Rehabilitation department students between the ages of 20-25, studying in the 3rd and 4th grades at Fırat University, will be included in the study. A questionnaire regarding the sociodemographic characteristics of the participants, Physical Activity Attitude Scale, International Physical Activity Survey Short Form, Postural Awareness Scale Turkish Version will be used as data collection tools.",[565,566,567,568],"Physical Activity Level","Postural Awareness","Physical Activity Attitude","University Students",[570,566,567,568],"Physical activity level",{"date":572,"type":38},"2025-03-03",{"date":574,"type":22},"2025-02-23",{"date":576,"type":22},"2025-06-20",{"name":43,"class":44},{"id":579,"slug":580,"hasResults":12,"nctId":581,"briefTitle":582,"officialTitle":583,"acronym":4,"eligibilityCriteria":584,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":585,"targetDuration":4,"studyType":23,"phases":586,"briefSummary":587,"conditions":588,"keywords":590,"overallStatus":184,"whyStopped":4,"lastUpdateSubmitDate":593,"lastUpdatePostDateStruct":594,"startDateStruct":595,"completionDateStruct":597,"leadSponsor":599,"locationsCount":45},"100580560","an-alternative-assessment-in-patients-with-rheumatoid-arthritis-6-minute-step-test-100580560","NCT06838884","An Alternative Assessment in Patients with Rheumatoid Arthritis: 6 Minute Step Test","An Alternative Assessment in Patients with Rheumatoid Arthritis: Comparing Bicycle Ergometer and 6 Minute Step Test and Proving the Validity of the 6 Minute Step Test","Inclusion Criteria:\n\n* RA patient\n* Over 18 years of age\n* 100 kilos or less\n* Patients who can walk independently without an assistive device\n\nExclusion Criteria:\n\n* History of serious heart and lung disease\n* Presence of severe musculoskeletal and joint disorders that may interfere with the conduct of the test\n* Arthroplasty or major operations on knee and hip joints\n* Uncontrolled hypertension\n* Inability to participate in physical tests involving walking and cycling",{"count":113,"type":22},[25],"Although joint involvement is predominant, RA is a systemic disease that can affect many organs. RA is a disease that includes changes such as inflammation, joint pain, fatigue, increased risk of coronary and heart disease. In patients with RA, exercises should be planned for decreased muscle strength, endurance, aerobic capacity and affected normal joint movements. Aerobic exercise capacity should be measured for individualized exercise planning in rehabilitation. Bicycle ergometer, one of the aerobic capacity tests, has been used in rehabilitation for a long time. Although it is frequently used in rehabilitation, it has some disadvantages. Therefore, other tests such as the step test can be used to eliminate these disadvantages of the bicycle ergometer and to assess functional capacity. The 6-minute step test (6MST), which requires less time and space, can be used as an alternative to assess exercise capacity. Patients will be evaluated at Firat University Hospital. Patients diagnosed with RA, older than 18 years of age and with a body weight of 100 kg or less (maximum weight supported by the stepper) will be included in the study.",[418,589],"6 Minutes Stepper Test",[422,591,592],"6 minutes stepper test","Bicycle ergometer","2025-02-25",{"date":545,"type":38},{"date":596,"type":22},"2025-02-18",{"date":598,"type":22},"2025-06-10",{"name":43,"class":44},{"id":601,"slug":602,"hasResults":12,"nctId":603,"briefTitle":604,"officialTitle":605,"acronym":4,"eligibilityCriteria":606,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":54,"enrollmentInfo":607,"targetDuration":4,"studyType":23,"phases":608,"briefSummary":609,"conditions":610,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":612,"lastUpdatePostDateStruct":613,"startDateStruct":614,"completionDateStruct":616,"leadSponsor":618,"locationsCount":4},"100574265","the-effect-of-laughter-yoga-on-hope-and-well-being-levels-of-earthquake-victim-mothers-100574265","NCT06757036","The Effect of Laughter Yoga on Hope and Well-Being Levels of Earthquake Victim Mothers","Effect of Laughter Yoga on Hope and Well-Being Levels of Earthquake Victim Mothers","Inclusion Criteria:\n\n* Having experienced the Kahramanmaraş earthquakes in any of the 11 provinces\n* Being willing to participate in the Laughter Yoga practice\n* Having a Post-Earthquake Trauma Symptoms Scale score above the threshold value\n\nExclusion Criteria:\n\n* Those with chronic illnesses that require medical treatment\n* Those who report receiving psychiatric treatment",{"count":82,"type":22},[25],"In Turkey, on February 6, 2023, an earthquake measuring 7.7 in magnitude centered in the Pazarcık district of Kahramanmaraş Province, followed by a second earthquake measuring 7.6 in magnitude centered in Elbistan, caused the deaths of 50,783 people in the provinces of Kahramanmaraş, Gaziantep, Şanlıurfa, Diyarbakır, Adana, Adıyaman, Osmaniye, Hatay, Kilis, Malatya and Elazığ. The magnitude of the cost impact of the 2023 Kahramanmaraş earthquake, which is described as the \"disaster of the century\" and calculated as 103.6 billion dollars, is as disturbing as the devastating effect of the disaster on individuals' levels of hope and well-being.\n\nIn line with previous studies, the high probability that socio-psychological effects will continue for a long time after the February 6, 2023 earthquakes necessitates physical and mental self-care activities to support the health and well-being of those affected by the disaster.\n\nIn order for the child's first teacher and guide to be his\u002Fher mother and for the widespread impact of our project to reach a wider audience directly and indirectly, the project will address the suitability of laughter yoga as a relaxing practice that will benefit earthquake-stricken mothers living in the provinces of Elazığ and Malatya, which were affected by the 2023 Kahramanmaraş Earthquakes.\n\nLaughter yoga, which has become increasingly popular worldwide and has recently been recognized as a low-cost, risk-free and less time-consuming practice for improving mental health, is a group-based laughter exercise that includes real-life laughter, light movement, stretching, rhythmic breathing and meditation. When articles evaluating the psychological and physiological effects of laughter yoga on individuals are examined, it is observed that promising results are obtained. A recent meta-analysis of 45 interventions that encourage laughter with 2,500 randomized participants found significant positive mental and physical health effects. Although challenging, laughing when sad can be \"a great way to balance sadness.\"\n\nHope is considered as a situation that includes the individual's high positive expectations for the future, their belief in the world, and the idea that life is worth living. High hope also has a positive effect on coping with traumatic experiences. It is known that individuals' well-being decreases as a result of traumatic life events and that they have difficulty coping with the current situation. In a study conducted on 188 adults who experienced the earthquake that occurred in the Pazarcık and Elbistan districts of Kahramanmaraş on February 6, 2023, it was pointed out that having positive resources such as hope and well-being is important for individuals to cope with post-traumatic symptoms.\n\nAlthough laughter yoga is expected to support hope and well-being, no study has revealed this relationship after a disaster. Therefore, evidence-based studies are needed to evaluate the effect of laughter yoga on hope and well-being in mothers, who are important building blocks of society after an earthquake. The aim of this study is to clarify the relationship between hope and well-being and laughter yoga after the Kahramanmaraş earthquakes.",[611],"Laughter Yoga","2025-02-24",{"date":593,"type":38},{"date":615,"type":22},"2025-04-01",{"date":617,"type":22},"2025-08",{"name":43,"class":44},""]