[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Florida Institute for Human and Machine Cognition\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":116},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,43,66,93],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100636944","adjuvant-nitrate-to-boost-exercise-induced-health-benefits-in-older-adults-100636944",false,"NCT07572266","Adjuvant Nitrate to Boost Exercise-induced Health Benefits in Older Adults","BOOST-X","Inclusion Criteria:\n\n1. Male or female aged 60 years or older\n2. Free of chronic disease or disorder that would preclude full participation or have the potential to confound results\n3. No structured exercise program (2 or more bouts\u002Fwk) within previous 12 months\n4. Cognitively capable of providing informed consent\n\nExclusion Criteria:\n\n1. BMI ≥ 30.0 kg\u002Fm2\n2. Neurodegenerative disease\n3. Neuromuscular, musculoskeletal or orthopedic disorder or condition that would limit ability to perform the exercise prescription and\u002For physical performance testing\n4. Diagnosed orthostatic hypotension, i.e., a drop in systolic blood pressure of at least 20 mmHg or a drop in diastolic blood pressure of at least 10 mmHg within three minutes of standing up from a sitting or lying position.\n5. Resting blood pressure \\\u003C90\u002F60 mmHg or \\>160\u002F95 mmHg\n6. Uncontrolled hypertension\n7. Any current cardiovascular disease or cardiopulmonary instability\n8. Recent cardiovascular event or procedure within the preceding 6 months\n\n   1. If valve replacement has been performed, patient may not be enrolled for 12 months after the procedure\n   2. Any mechanical valve replacement that requires continuous warfarin anti-coagulation\n9. Anemia: Hgb \\\u003C11.0 (♂),10.0 (♂) gm\u002Fdl\n10. Diabetes with HgbA1c \\>7.0% or fasting blood glucose ≥ 130 mg\u002Fdl\n11. Liver disease with ALT \\> 52 U\u002Fl)\n12. Chronic kidney disease (eGFR \\\u003C 45)\n13. Any current infectious disease\n14. Any other disease or disorder that could influence exercise response, preclude full participation or have the potential to confound results (e.g., chronic lung disease, cognitive impairment, current cancer diagnosis or within 2 yr remission, cerebrovascular disease, pain)\n15. Life expectancy \\\u003C 1 year Medications \u002F lifestyle\n16. Insulin sensitizing\u002Fblood glucose lowering agents such as metformin\n17. Currently on or have used GLP-1 agonist or other metabolic \u002F weight loss drug in previous 12 weeks\n18. Use of nitrate medications\n19. High dose statin (≥40 mg\u002Fd simvastatin equivalence)\n20. Chronic corticosteroids\n21. Testosterone or other anabolic\u002Fandrogenic hormone therapy\n22. Lidocaine allergy\n23. Regular tobacco use and\u002For vaping \\> 1\u002Fwk\n24. Use of cannabis \\> 1\u002Fwk\n25. Excessive alcohol consumption (3 drinks\u002Fd or 7 drinks\u002Fwk for females; 4 drinks\u002Fd or 14 drinks\u002Fwk for males)\n26. Use of illicit drugs (e.g., cocaine, opioids)\n27. Unable to commit to \\~4 months required to complete the study",true,"ALL","60 Years",{"count":20,"type":21},226,"ESTIMATED","INTERVENTIONAL",[24],"NA","Aging-related functional declines are thought to be caused by hallmark biological processes that ultimately manifest in physical, mental, and metabolic impairments to compromise intrinsic capacity and healthspan. Exercise is the only multipotent treatment with promise to mitigate many of the aging hallmarks, but there is substantial variability in individual exercise responsiveness. Thus, the investigators approach to boosting exercise responsiveness in aging is to combine an exercise training prescription containing both endurance and resistance training (in alignment with DHHS guidelines) with a nitrate-enriched dietary supplement to augment the cellular, tissue, and systemic adaptations that induce myriad health benefits of exercise in older adults.",[27,28,29],"Aging","Aging Well","Healthy Aging","NOT_YET_RECRUITING","2026-04-30",{"date":33,"type":34},"2026-05-07","ACTUAL",{"date":36,"type":21},"2026-05",{"date":38,"type":21},"2031-05",{"name":40,"class":41},"Florida Institute for Human and Machine Cognition","OTHER",1,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":49,"eligibilityCriteria":50,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":51,"targetDuration":4,"studyType":22,"phases":53,"briefSummary":54,"conditions":55,"keywords":4,"overallStatus":56,"whyStopped":4,"lastUpdateSubmitDate":57,"lastUpdatePostDateStruct":58,"startDateStruct":60,"completionDateStruct":62,"leadSponsor":64,"locationsCount":65},"100555061","multidimensional-predictive-modeling-to-understand-mechanisms-of-exercise-response-heterogeneity-in-older-adults-m3ax-100555061","NCT06507189","Multidimensional Predictive Modeling to Understand Mechanisms of Exercise Response Heterogeneity in Older Adults (M3AX)","Multidimensional Predictive Modeling to Understand Mechanisms of Exercise Response Heterogeneity in Older Adults","M3AX","Inclusion Criteria:\n\n1. Male or female aged 60 or above\n2. Free of chronic disease\n3. No structured exercise program (2 or more bouts\u002Fwk) within previous 12 months\n4. Cognitively capable of providing informed consent\n\nExclusion Criteria:\n\n1. Neuromuscular or musculoskeletal disorder that would limit ability to perform the exercise and\u002For testing bouts\n2. Cardiopulmonary disorders or reduced breathing capacity\n3. Metabolic diseases including markers of liver disease (ALT \\> 52 U\u002Fl) and type 2 diabetes (HbA1C ≥ 6.5, fasting blood glucose ≥ 126 mg\u002Fdl)\n4. Any other disease or disorder that would influence exercise response (e.g., chronic kidney disease, dementia, current cancer diagnosis or within 2 yr remission, cerebrovascular disease)\n5. History of chemotherapy within 5 years\n6. Any current infectious disease\n7. Life expectancy \\\u003C 1 year\n8. Insulin sensitizing\u002Fblood glucose lowering agents such as metformin\n9. High dose statin (dose equivalent to ≥40 mg\u002Fd simvastatin)\n10. Lidocaine allergy\n11. Regular tobacco use and\u002For vaping\n12. Excessive alcohol consumption (3 drinks\u002Fd or 7 drinks\u002Fwk for females; 4 drinks\u002Fd or 14 drinks\u002Fwk for males)\n13. BMI \\\u003C 35.0 kg\u002Fm2\n14. Unable to commit to \\~6 months required to complete the study",{"count":52,"type":21},250,[24],"Aging-related functional declines are thought to be caused by hallmark biological processes that ultimately manifest in physical, mental, and metabolic impairments that compromise healthspan and quality of life. Exercise is a multipotent treatment with promise to mitigate most aging hallmarks, but there is substantial variability in exercisƒe responsiveness. Combining endurance and resistance training in alignment with public health guidelines will be used to better understand variable exercise responsiveness in older adults with the ultimate goal of improving each older adult's capacity to attain the many health benefits of exercise.",[27,28],"RECRUITING","2026-04-17",{"date":59,"type":34},"2026-04-22",{"date":61,"type":34},"2025-01-27",{"date":63,"type":21},"2029-08-31",{"name":40,"class":41},2,{"id":67,"slug":68,"hasResults":11,"nctId":69,"briefTitle":70,"officialTitle":70,"acronym":4,"eligibilityCriteria":71,"healthyVolunteers":11,"sex":17,"minAge":72,"maxAge":73,"enrollmentInfo":74,"targetDuration":4,"studyType":22,"phases":76,"briefSummary":77,"conditions":78,"keywords":81,"overallStatus":56,"whyStopped":4,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":42},"100561562","innovative-multi-variable-biofeedback-for-improving-gait-performance-in-individuals-with-diabetic-peripheral-neuropathy-100561562","NCT06591780","Innovative Multi-Variable Biofeedback for Improving Gait Performance in Individuals With Diabetic Peripheral Neuropathy","Inclusion Criteria:\n\n* Able to walk 10-meters independently without an assistive device\n* Sufficient cardiovascular and musculoskeletal health to walk on a treadmill for 6 minutes at a self-selected speed\n* Diagnosis of diabetes mellitus\n* Diagnosis of diabetic peripheral neuropathy by a physician\n* Foot examination within the past 6 months documenting ambulatory status\n* Physician clearance\n\nExclusion Criteria:\n\n* History of amputation\n* Active ulceration\n* Medial column deformity\n* Severe cognitive impairment (MoCA \\< 10)\n* Severe visual impairment\n* History of Charcot osteoarthropathy\n* History of posterior muscle group lengthening\n* History of lower extremity joint replacement\n* History of lower extremity and\u002For foot surgery affecting walking mechanics\n* Orthopaedic problems of the lower limbs or spine due to other medical conditions (not diabetes or DPN) that limit walking or cause pain during walking\n* Improper footwear for walking and community ambulation\n* Cardiovascular or medical condition affecting ability to walk safely\n* History of unexplained dizziness or fainting in the past 2 months\n* Allergy to adhesive tape or rubbing alcohol","45 Years","90 Years",{"count":75,"type":21},25,[24],"This study aims to collect data to improve gait function in individuals with Diabetic Peripheral Neuropathy (DPN).\n\nThe primary goals are to evaluate:\n\n* Biomechanical mechanisms contributing to abnormal plantar pressure and propulsion during gait in individuals with DPN\n* Biofeedback-induced changes in plantar pressure, propulsion, and biomechanics during gait in individuals with DPN\n\nThe participants will be required to complete\n\n* Questionnaires\n* Clinical examination\n* 3-Dimensional gait analysis on an instrumented treadmill\n* Visual and auditory biofeedback on the participant's propulsion and plantar pressure metrics provided by a projector screen during walking",[79,80],"Diabetic Peripheral Neuropathy","Diabetes Mellitus",[82,83,84],"anterior ground reaction force","biofeedback-induced changes in plantar pressure","diabetic peripheral neuropathy","2026-03-09",{"date":87,"type":34},"2026-03-11",{"date":89,"type":34},"2025-10-20",{"date":91,"type":21},"2027-06-01",{"name":40,"class":41},{"id":94,"slug":95,"hasResults":11,"nctId":96,"briefTitle":97,"officialTitle":98,"acronym":4,"eligibilityCriteria":99,"healthyVolunteers":16,"sex":17,"minAge":72,"maxAge":4,"enrollmentInfo":100,"targetDuration":4,"studyType":22,"phases":102,"briefSummary":103,"conditions":104,"keywords":105,"overallStatus":56,"whyStopped":4,"lastUpdateSubmitDate":108,"lastUpdatePostDateStruct":109,"startDateStruct":111,"completionDateStruct":113,"leadSponsor":115,"locationsCount":42},"100513428","walking-function-in-diabetic-peripheral-neuropathy-100513428","NCT05965336","Walking Function in Diabetic Peripheral Neuropathy","Walking Function in Individuals With Diabetic Peripheral Neuropathy: Biomechanical Mechanisms and Implications for Clinical Outcomes and Gait Retraining","Inclusion Criteria for All Participants:\n\n1. Age 45+ years\n2. Able to walk 10-meters independently without an assistive device\n3. Sufficient cardiovascular and musculoskeletal health to walk on a treadmill for 1-minute at self-selected speed\n\nInclusion Criteria for Participants with DPN:\n\n1. Diagnosis of DM\n2. Diagnosis of DPN by a physician\n3. Foot examination within the past 6 months to document ambulatory status\n4. Physician's clearance\n\nExclusion Criteria for Healthy Able-Bodied Individuals:\n\n1. History of neurologic disease\n2. History of orthopaedic disease affecting the lower extremities\n3. History of injury or pain affecting the lower extremity or walking function within the past 6 months\n\nExclusion Criteria for All Participants:\n\n1. History of amputation\n2. Active ulceration\n3. Medial column deformity\n4. History of Charcot osteoarthropathy\n5. History of posterior muscle group lengthening\n6. History of lower extremity joint replacement\n7. History of lower extremity and\u002For foot surgery affecting walking mechanics\n8. Orthopaedic problems of the lower limbs or spine due to other medical conditions (not DM or DPN) that limit walking or cause pain during walking\n9. Improper footwear for walking and community ambulation\n10. Cardiovascular or medical condition affecting ability to walk safely\n11. History of unexplained dizziness or fainting in the past 2 months\n12. Allergy to adhesive tape or rubbing alcohol\n13. Individuals who are pregnant, prisoners, or not yet adults\n14. Inability to communicate with the investigators\n15. Inability to provide written informed consent",{"count":101,"type":21},50,[24],"The purpose of this study is to 1) examine the differences in walking function and movement patterns between individuals with diabetic peripheral neuropathy and healthy adults with no known conditions; 2) examine if receiving feedback on walking form will help change walking patterns; and 3) examine the feasibility, safety, and preliminary effects of walking training with feedback on walking function in individuals with diabetic peripheral neuropathy.",[79],[106,107],"Diabetes","Biofeedback-induced changes","2025-07-21",{"date":110,"type":34},"2025-07-24",{"date":112,"type":34},"2024-12-05",{"date":114,"type":21},"2027-03",{"name":40,"class":41},""]