[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Florida State University\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":612},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,50,0,25,[9,46,71,99,118,137,155,194,218,242,268,294,316,337,360,383,405,427,452,463,488,508,533,559,587],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":4,"eligibilityCriteria":16,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100054326","dose-response-effects-of-a-brief-audio-guided-mindfulness-intervention-for-acute-pain-100054326",false,"NCT07562412","Dose-Response Effects of a Brief Audio-Guided Mindfulness Intervention for Acute Pain","Dose-Response Effects of a Brief Audio-Guided Mindfulness Intervention for Acute Pain While Awaiting Orthopedic Care","Inclusion Criteria:\n\n* Receiving treatment at Tallahassee Orthopedic Center\n* Understanding English instructions fluently\n* Being 18 years of age or older\n\nExclusion Criteria:\n\n* Unable to consent because of physical or mental incapacity.","ALL","18 Years",{"count":20,"type":21},300,"ESTIMATED","INTERVENTIONAL",[24],"NA","This project is a single-site, three-arm, randomized controlled trial investigating whether different length audio-recorded mindfulness practices differentially decrease pain among patients in a waiting room awaiting orthopedic care.",[27,28,29,30,31,32],"Pain","Pain Management","Mindfulness","Orthopedic","Acute Pain","Chronic Pain","RECRUITING","2026-07-10",{"date":36,"type":37},"2026-07-13","ACTUAL",{"date":39,"type":37},"2026-04-29",{"date":41,"type":21},"2027-04-30",{"name":43,"class":44},"Florida State University","OTHER",1,{"id":47,"slug":48,"hasResults":12,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":54,"sex":17,"minAge":18,"maxAge":55,"enrollmentInfo":56,"targetDuration":4,"studyType":22,"phases":58,"briefSummary":59,"conditions":60,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":45},"100053624","the-increasing-mindfulness-engagement-project-100053624","NCT07170202","The Increasing Mindfulness Engagement Project","Translating Behavioral Economics Strategies to Culturally Tailor a Mobile Health Mindfulness Intervention to Reduce Risky Drinking Behaviors in Emerging Adult College Student Students","TIMEProject","Inclusion Criteria:\n\n18-29 years old First-generation college student Undergraduate college student Living in the United States Meet criteria for binge drinking (5 drinks in about 2 hours) or heavy drinking (more than 14 drinks per week).",true,"29 Years",{"count":57,"type":21},40,[24],"The goal of this clinical trial is to examine the feasibility and acceptability of different types of text messages and a integrated gaming app to increase engagement in a mindfulness mobile health application.\n\n1. Does receiving text messages increase engagement in a mindfulness app?\n2. Does an integrated gaming app increase engagement in a mindfulness app?\n\nResearchers will examine whether participants engage more in a mindfulness mobile health application if they receive text messages and if they engage in additional gaming app on their smartphone. Participants will:\n\n1. Use a mindfulness and gaming mobile health application for 28-days.\n2. Complete a pre-study survey, post-study survey, follow-up interview, and 3-month follow-up survey in addition to daily brief surveys.",[61,62,63],"Healthy Participants","Feasibility Studies","Acceptability","2026-07-09",{"date":36,"type":37},{"date":67,"type":37},"2025-09-30",{"date":69,"type":21},"2027-08-06",{"name":43,"class":44},{"id":72,"slug":73,"hasResults":12,"nctId":74,"briefTitle":75,"officialTitle":76,"acronym":4,"eligibilityCriteria":77,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":78,"enrollmentInfo":79,"targetDuration":4,"studyType":22,"phases":81,"briefSummary":82,"conditions":83,"keywords":87,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":45},"100624181","respiratory-muscle-training-to-improve-cerebrovascular-and-immune-function-100624181","NCT07406295","Respiratory Muscle Training to Improve Cerebrovascular and Immune Function","Novel Respiratory Muscle Training for Improving Cerebrovascular Function and Immune Status in Adults With Obesity","Inclusion Criteria:\n\n* Body mass index greater than or equal to 30 kg\u002Fm2\n* Waist circumference greater or equal to 88 cm for females and greater than or equal to 102 cm for males\n\nExclusion Criteria:\n\n* Not weight stable (\\\u003C5% change in body mass over the past six months)\n* Overt cardiovascular, neurological, renal, liver, and\u002For metabolic illness (e.g., diabetes mellitus)\n* Current, or history of uncontrolled, Stage 2 hypertension (blood pressure \\>140 \u002F 90 mmHg; anti-hypertensive medications are permitted)\n* Diagnosed obstructive sleep apnea\n* Previous bariatric surgery\n* Diagnosis or signs (e.g., values below the lower limit of normal) of overt airway disease(s)\n* Current or recent (regular use within the past 6 months) use of tobacco or nicotine products (e.g., cigarettes, vaping)\n* Pregnant (self-reported and confirmed via urine pregnancy test), lactating (self-reported), or post-menopausal (self-reported) females\n* Prisoners\n\nPer the POWERbreathe® company:\n\n* Patients who have undergone recent abdominal surgery and those with abdominal hernia.\n* Asthma patients who have a very low symptom perception and suffer from frequent, severe exacerbations or with an abnormally low perception of dyspnea.\n* If a patient is suffering from a ruptured eardrum or any other condition of the ear.\n* Patients with marked elevated left ventricular end-diastolic volume and pressure.\n* Patients with worsening heart failure signs and symptoms after training. If an individual is suffering from a cold, sinusitis or respiratory tract infection, it is advised that they do not use the POWERbreathe device.","45 Years",{"count":80,"type":21},30,[24],"Millions of adults in America have too much body fat, resulting in obesity. Obesity is detrimental to health and causes disease. Obesity reduces brain health, which causes the brain to function less effectively. Additionally, a lack of exercise contributes to poorer brain health. Most individuals feel they do not have time to exercise. There is a need for a quicker type of training that improves brain health. Newly developed breathing exercises could be a time-efficient, cost-effective, and home-based practice to increase brain health. This practice acts as weightlifting for breathing muscles.\n\nThese new breathing exercises have already been shown to increase heart health. Heart health is linked to brain health; if an intervention helps the heart, it is likely to also help the brain. It is currently unknown if breathing training can improve brain health in younger adults with obesity. The investigators will utilize the same 8-week program shown to improve heart health. Testing will be conducted before and after the breathing training. The first part of the study will determine if breathing exercises help brain health.\n\nObesity also causes inflammation. This is measured via blood but affects the entire body. It is thought to cause some of the negative outcomes of obesity. By lowering inflammation, it is likely to improve overall health. Breathing exercises may reduce inflammation, but more research is required. The second part of this study will determine whether breathing exercises help reduce inflammation. This study will determine if brain health can be improved in adults with obesity. This could help 40% of American adults with obesity to live longer and healthier lives.",[84,85,86],"Obesity","Cerebrovascular Function","Immune Cells Activity",[88,89,90],"Transcranial Doppler","Inspiratory Muscle Strength Training","Cerebrovascular Reactivity","2026-06-24",{"date":93,"type":37},"2026-06-26",{"date":95,"type":37},"2026-01-27",{"date":97,"type":21},"2028-05-01",{"name":43,"class":44},{"id":100,"slug":101,"hasResults":12,"nctId":102,"briefTitle":103,"officialTitle":103,"acronym":4,"eligibilityCriteria":104,"healthyVolunteers":54,"sex":17,"minAge":18,"maxAge":105,"enrollmentInfo":106,"targetDuration":4,"studyType":22,"phases":107,"briefSummary":108,"conditions":109,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":111,"startDateStruct":113,"completionDateStruct":115,"leadSponsor":117,"locationsCount":45},"100610135","handgrip-training-and-brain-blood-flow-regulation-100610135","NCT07223645","Handgrip Training and Brain Blood Flow Regulation","Inclusion Criteria:\n\n* 18 to 35 years old\n* Body mass index ≤30 kg\u002Fm2 (without obesity)\n* Physically inactive (not meeting the current recommendations of ≥150 minutes per week of moderate-to-vigorous aerobic exercise and not ≥2 days per week of resistance training) in last 6 months\n* Have a smartphone and are willing to download mobile applications used in this project\n\nExclusion Criteria:\n\n* Having an overt chronic condition (e.g., cardiovascular, cerebrovascular, etc.)\n* Being pregnant, planning to become pregnant, or breastfeeding\u002Flactating\n* Regular use of nicotine products in the past 6 months\n* Recent head injury\u002Ftrauma or concussion","35 Years",{"count":57,"type":21},[24],"This study aims to investigate the effect of isometric handgrip training on brain blood vessel function in physically inactive adults. Isometric handgrip training is a promising strategy for lowering blood pressure and improving vascular health, but no previous investigations have studied the effect of training on markers of brain blood vessel function. Based on previous work showing improvements in vascular function after isometric handgrip training, we hypothesize that isometric handgrip training will improve key markers of cerebrovascular function.",[110],"Inactivity\u002FLow Levels of Exercise",{"date":112,"type":37},"2026-06-25",{"date":114,"type":37},"2025-10-27",{"date":116,"type":21},"2028-10-27",{"name":43,"class":44},{"id":119,"slug":120,"hasResults":12,"nctId":121,"briefTitle":122,"officialTitle":122,"acronym":4,"eligibilityCriteria":123,"healthyVolunteers":54,"sex":17,"minAge":18,"maxAge":78,"enrollmentInfo":124,"targetDuration":4,"studyType":126,"phases":4,"briefSummary":127,"conditions":128,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":131,"startDateStruct":132,"completionDateStruct":134,"leadSponsor":136,"locationsCount":45},"100487846","breathing--blood-pressure-100487846","NCT05632406","Breathing & Blood Pressure","Inclusion Criteria:\n\n• Body mass index values of ≤40 kg\u002Fm\\^2\n\nExclusion Criteria:\n\n* Not weight stable (\\\u003C5% change in body mass over the past six months)\n* Overt cardiovascular, neurological, renal, liver, and\u002For metabolic illness (e.g., diabetes mellitus)\n* Current, or history of uncontrolled, Stage 2 hypertension (blood pressure \\>140 \u002F 90 mmHg; anti-hypertensive medications are permitted)\n* Diagnosed obstructive sleep apnea\n* Previous bariatric surgery\n* Diagnosis or signs (e.g., values below the lower limit of normal) of overt airway disease(s)\n* Current or recent (regular use within the past 6 months) use of tobacco or nicotine products (e.g., cigarettes, vaping)\n* Per the POWERbreathe® company:\n* Patients who have undergone recent abdominal surgery and those with abdominal hernia.\n* Asthma patients who have a very low symptom perception and suffer from frequent, severe exacerbations or with an abnormally low perception of dyspnoea.\n* If a patient is suffering from a ruptured eardrum or any other condition of the ear.\n* Patients with marked elevated left ventricular end-diastolic volume and pressure.\n* Patients with worsening heart failure signs and symptoms after a respiratory\u002Finspiratory muscle training (IMT) session\n* If you are suffering from a cold, sinusitis, or respiratory tract infection, we advise that you do not use your POWERbreathe IMT device.\n* Individuals who are not yet adults (infants, children, teenagers)\n* Pregnant (self-reported and urine pregnancy test conducted), lactating (self-reported), or post-menopausal (self-reported) females\n* Prisoners",{"count":125,"type":21},80,"OBSERVATIONAL","The purpose of this study is to determine the effect of obesity on cardiovascular responses during various breathing maneuvers.",[129,130],"Healthy","Overweight and Obesity",{"date":93,"type":37},{"date":133,"type":37},"2023-10-25",{"date":135,"type":21},"2027-06-30",{"name":43,"class":44},{"id":138,"slug":139,"hasResults":12,"nctId":140,"briefTitle":141,"officialTitle":142,"acronym":4,"eligibilityCriteria":143,"healthyVolunteers":54,"sex":17,"minAge":18,"maxAge":78,"enrollmentInfo":144,"targetDuration":4,"studyType":22,"phases":146,"briefSummary":147,"conditions":148,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":149,"startDateStruct":150,"completionDateStruct":152,"leadSponsor":154,"locationsCount":45},"100474571","inspiratory-muscle-strength-training-in-adults-with-obesity-100474571","NCT05459636","Inspiratory Muscle Strength Training in Adults With Obesity","Time-Efficient Inspiratory Muscle Strength Training as a New Approach to Lower Blood Pressure, Improve Respiratory Function, and Reduce Exertional Dyspnea in Adults With Obesity","Inclusion Criteria:\n\n\\- Body mass index 30 - 40 kg\u002Fm2\n\nExclusion Criteria:\n\n* Not weight stable (\\\u003C5% change in body mass over the past six months)\n* Overt cardiovascular, neurological, renal, liver, and\u002For metabolic illness (e.g., diabetes mellitus)\n* Current, or history of uncontrolled, Stage 2 hypertension (blood pressure \\>140 \u002F 90 mmHg; anti-hypertensive medications are permitted)\n* Diagnosed obstructive sleep apnea\n* Previous bariatric surgery\n* Diagnosis or signs (e.g., values below the lower limit of normal) of overt airway disease(s)\n* Current or recent (regular use within the past 6 months) use of tobacco or nicotine products (e.g., cigarettes, vaping)\n* Pregnant (self-reported and confirmed via urine pregnancy test), lactating (self-reported), or post-menopausal (self-reported) females\n* Prisoners\n* Per the POWERbreathe® company:\n\n  * Patients who have undergone recent abdominal surgery and those with abdominal hernia.\n  * Asthma patients who have a very low symptom perception and suffer from frequent, severe exacerbations or with an abnormally low perception of dyspnea.\n  * If a patient is suffering from a ruptured eardrum or any other condition of the ear.\n  * Patients with marked elevated left ventricular end-diastolic volume and pressure.\n  * Patients with worsening heart failure signs and symptoms after training.\n  * If an individual is suffering from a cold, sinusitis or respiratory tract infection, it is advised that they do not use the POWERbreathe device.",{"count":145,"type":21},44,[24],"The purpose of this study is to determine whether inspiratory muscle strength training reduces blood pressure in adults with obesity.",[84],{"date":93,"type":37},{"date":151,"type":37},"2023-12-07",{"date":153,"type":21},"2027-07-31",{"name":43,"class":44},{"id":156,"slug":157,"hasResults":12,"nctId":158,"briefTitle":159,"officialTitle":160,"acronym":4,"eligibilityCriteria":161,"healthyVolunteers":54,"sex":17,"minAge":162,"maxAge":163,"enrollmentInfo":164,"targetDuration":4,"studyType":22,"phases":166,"briefSummary":167,"conditions":168,"keywords":173,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":186,"lastUpdatePostDateStruct":187,"startDateStruct":189,"completionDateStruct":191,"leadSponsor":193,"locationsCount":45},"100642187","pulse-education-and-children-100642187","NCT07648446","Pulse Education and Children","Enhancing Dietary Perception and Acceptance of Pulses in Children Through an Innovative Nutritional Intervention Program: Bringing Pulses to the Dining Table","Inclusion Criteria:\n\n* Children aged 6-13 years old\n* Ability to speak English\n\nExclusion Criteria:\n\n* Frequent pulse consumers (\\>0.5 cup\u002Fweek for females and \\>1 cup \u002F week for males)\n* Antibiotic use in the past 3 months\n* Diagnosed metabolic\u002Fgut diseases (ulcerative colitis, Crohn's disease, diverticulosis, peptic ulcers, small intestinal bacterial overgrowth, short bowel syndrome, irritable bowel syndrome, gastroesophageal reflux disease), neurological (multiple sclerosis, meningitis, recent stroke) or endocrine disorders (uncontrolled thyroid disorders, growth hormone disorders, adrenal gland disorders, uncontrolled diabetes - A1C \\> 9%).\n* Current use of medications or nutrition supplements\n* Individuals following a specific dietary patten\n* Individuals who gained or lost \\>5% body weight within the past 6 months\n* Those involved in another study concurrently\n* Any allergies to pulses\n* Intake of pre\u002Fpro\u002Fpostbiotics in the past 3 months","6 Years","13 Years",{"count":165,"type":21},60,[24],"This parallel-arm, randomized controlled trial will evaluate the effectiveness of a 6-week pulse-focused nutrition intervention in school-aged children (6-13 years). The study aims to assess adherence to a pulse-based diet providing 1.5 cups of pulses per week and to examine the effects of whole-cooked pulse consumption on gut health, including gut microbiome composition, metabolomic profiles, and gut barrier function. Secondary objectives include evaluating the impact of pulse consumption on markers of metabolic health and inflammation. Forty participants will be randomized to either a pulse-focused nutrition education program with weekly provision of pre-measured pulses (black beans, lentils, and chickpeas) or a pulse-focused nutrition education program in which participants independently procure their own pulses. Participants will follow the assigned intervention for 6 weeks.",[169,170,171,172],"Dysbiosis","Cardiometabolic Health Indicators","Education on Feeding and Health Status","Gut Motility",[174,175,176,177,178,179,180,181,182,183,184,185],"gut","git microbiome","children","pediatric","pulses","beans","metabolomics","nutrition education","dietary adherence","fiber inake","plant-based","pulse consumption","2026-06-11",{"date":188,"type":37},"2026-06-15",{"date":190,"type":21},"2026-08-01",{"date":192,"type":21},"2028-12-31",{"name":43,"class":44},{"id":195,"slug":196,"hasResults":12,"nctId":197,"briefTitle":198,"officialTitle":199,"acronym":4,"eligibilityCriteria":200,"healthyVolunteers":54,"sex":17,"minAge":201,"maxAge":202,"enrollmentInfo":203,"targetDuration":4,"studyType":22,"phases":204,"briefSummary":205,"conditions":206,"keywords":208,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":186,"lastUpdatePostDateStruct":213,"startDateStruct":214,"completionDateStruct":216,"leadSponsor":217,"locationsCount":45},"100642470","interactive-effects-of-sodium-and-potassium-on-vascular-health-in-older-adults-100642470","NCT07649005","Interactive Effects of Sodium and Potassium on Vascular Health in Older Adults","Exploring the Interactive Effects of Sodium and Potassium Intake on Vascular Health in Older Adults","Inclusion Criteria:\n\n* Adults ages 55-75 years\n* At least one-year post-menopause (females)\n* Willing and able to attend laboratory visits\n\nExclusion Criteria:\n\n* BMI ≥35 kg\u002Fm2\n* Seated blood pressure \\>135\u002F85 mmHg\n* Current diagnosis or history of cardiovascular disease, diabetes, renal disease, cancer, or major cardiovascular event (e.g. heart attack or stroke)\n* Taking exogenous hormones or hormone replacement therapy\n* Following a vegan or gluten free diet\n* Significant weight loss (\\>10% of body weight) in the last 6 months, or actively trying to lose weight\n* Current or recent use of a diuretic (within the past 6 months) (e.g. spironolactone, eplerenone)\n* Current or recent use of a potassium binding medication (within the past 6 months)\n* Current use of blood pressure lowering medications (e.g. ACE inhibitors, calcium channel blockers, diuretics, vasodilators, beta blockers, AngII receptor blockers)\n* Current or recent use of the medication trimethoprim\n* Elevated blood lipids (LDL cholesterol ≥190 mg\u002FdL)\n* Elevated serum potassium level (\\>5.1 mmol\u002FL)\n* Elevated BUN (\\>22 mg\u002FdL)\n* Elevated creatinine (\\>1.2 mg\u002FdL)\n* Low eGFR (\\\u003C90 mL\u002Fmin\u002F1.73 m²)\n* Current or recent use of tobacco, nicotine, or illicit drugs\n* Radical hysterectomy or oophorectomy (females)","55 Years","75 Years",{"count":80,"type":21},[24],"The goal of this clinical trial is to determine if a high potassium intake can counteract the harmful effects of excess sodium on endothelial function in older adults with no history of cardiometabolic disease. The main questions it aims to answer are:\n\n1. Can a high potassium intake attenuate dietary sodium-induced endothelial dysfunction in older adults.\n2. Do changes in endothelial function in response to alterations in sodium and potassium intake differ by sex.\n\nParticipants will participants will consume three controlled diets for 10 days each with a minimum 14-day washout between interventions. The order in which participants consume the diets will be randomized. The study diets will vary in sodium and potassium content. Measures of cardiovascular health (blood pressure, arterial stiffness, endothelial function) will be assessed at the end of each diet.",[207],"Healthy Older Adults",[209,210,211,212],"sodium","potassium","endothelial function","cardiovascular disease risk factors",{"date":188,"type":37},{"date":215,"type":37},"2026-03-24",{"date":135,"type":21},{"name":43,"class":44},{"id":219,"slug":220,"hasResults":12,"nctId":221,"briefTitle":222,"officialTitle":223,"acronym":4,"eligibilityCriteria":224,"healthyVolunteers":54,"sex":17,"minAge":162,"maxAge":163,"enrollmentInfo":225,"targetDuration":4,"studyType":22,"phases":227,"briefSummary":228,"conditions":229,"keywords":230,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":236,"lastUpdatePostDateStruct":237,"startDateStruct":239,"completionDateStruct":240,"leadSponsor":241,"locationsCount":45},"100642795","almonds-gut-microbiome-and-kids-100642795","NCT07636850","Almonds, Gut Microbiome and Kids","Nutritional Impact of Almond Butter on Gut Microbiome and Cardiometabolic Health in School-Aged Children: A Novel and Timely Pilot Randomized Controlled Trial","Inclusion Criteria:\n\n* Enrolled in elementary or middle school (grades 1-8)\n* Aged 6-13 years old\n* Ability to speak and read in English\n\nExclusion Criteria:\n\n* Intake of antibiotics in the last 3 months\n* Intake of pre\u002Fpro\u002Fpostbiotics in the last 3 months\n* Food allergy to study foods\n\n  ◦ Any allergy to nuts or almonds\n* Any allergy to the isocaloric snack (chocolate or wheat)\n* Regular consumption of nuts or almonds greater than 2 servings \u002F week\n* Gastrointestinal disease (ulcerative colitis, Crohn's disease, diverticulosis, peptic ulcers, small intestinal bacterial overgrowth, short bowel syndrome, irritable bowel syndrome, gastroesophageal reflux disease), neurological (multiple sclerosis, meningitis, recent stroke) or endocrine disorders (uncontrolled thyroid disorders, growth hormone disorders, adrenal gland disorders, uncontrolled diabetes - A1C \\> 9%).",{"count":226,"type":21},70,[24],"This 8-week parallel-arm randomized controlled trial (N=70; ages 6-13) will determine the impact of daily almond butter consumption on gut microbiome composition and function, intestinal barrier integrity, and cardiometabolic health in school-aged children. Participants will be randomized to either a once-daily snack of personalized-portion almond butter (ALB; 16g, Creamy Natural Almond Butter) or an isocaloric nut-free chocolate spread control (CTL; 16g, Cadbury Milk Chocolate), each served on two plain unsalted saltine crackers, added to their habitual diet. The primary outcomes include oro-gut microbial composition and diversity, gut microbial functional capacity and metabolomics (SCFAs, bile acids, amino acid metabolites), and intestinal barrier integrity. Secondary outcomes include fasting cardiometabolic markers, systemic inflammation, appetite-regulatory and metabolic hormones, and sleep-related biomarkers. Feasibility, adherence (weekly logs; serum α-tocopherol), and precision nutrition potential will also be assessed, with stratified analyses by age, sex, BMI, ethnicity, and pubertal stage.\n\nThis pilot trial will generate the first multi-omics characterization of almond butter's effects on the gut-immune-metabolic axis in children.",[169,170],[174,231,176,177,232,233,234,235,180],"gut microbiome","sleep quality","almonds","nuts","almond butter","2026-06-05",{"date":238,"type":37},"2026-06-09",{"date":190,"type":21},{"date":192,"type":21},{"name":43,"class":44},{"id":243,"slug":244,"hasResults":12,"nctId":245,"briefTitle":246,"officialTitle":247,"acronym":248,"eligibilityCriteria":249,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":250,"targetDuration":4,"studyType":22,"phases":252,"briefSummary":253,"conditions":254,"keywords":257,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":236,"lastUpdatePostDateStruct":261,"startDateStruct":263,"completionDateStruct":265,"leadSponsor":267,"locationsCount":45},"100603761","the-fundamental-adaptive-skills-training-100603761","NCT07140718","The Fundamental Adaptive Skills Training","Piloting and Evaluating the Fundamental Adaptive Skills Training (FAST): a New Digitally Augmented Single-Session Transdiagnostic Resilience Intervention","FAST","Inclusion Criteria:\n\n* Aged 18+\n* At-risk for emotional disorders as indicated by a PANAS-NA Score \\>= 20\n* Ability to use a computer or smartphone\n* Currently enrolled at college\u002Funiversity at the time of study enrollment\n\nExclusion criteria:\n\n* Adults aged 17 and under\n* PANAS-NA Score \\\u003C= 19\n* Inability to use a computer or smartphone\n* Not currently enrolled at college\u002Funiversity at the time of study enrollment",{"count":251,"type":21},105,[24],"The present study seeks to develop, refine, and test a novel psychological treatment for boosting mental health resilience among college students. This Fundamental Adaptive Skills Training (FAST) will be evaluated in a randomized controlled trial. We will seek to recruit 5 undergraduate students as participants for a pilot phase and 100 undergraduate students for a randomized controlled trial. The primary questions we are seeking to answer in this trial are:\n\nDo participants rate the FAST intervention as acceptable? Does FAST improve sleep quality, physical activity, anxiety sensitivity, loneliness, and social isolation for college students?\n\nParticipants will:\n\nReceive the active FAST or a placebo control Relaxation and Mindfulness Training (RMT) and will complete measures at baseline, week 2, and week 4.",[255,256],"Fundamental Adaptive Skills Training","Relaxation and Mindfulness Training",[258,259,260],"Transdiagnostic","Digital Mental Health","Resilience",{"date":262,"type":37},"2026-06-08",{"date":264,"type":37},"2025-09-20",{"date":266,"type":21},"2027-06-05",{"name":43,"class":44},{"id":269,"slug":270,"hasResults":12,"nctId":271,"briefTitle":272,"officialTitle":272,"acronym":4,"eligibilityCriteria":273,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":55,"enrollmentInfo":274,"targetDuration":4,"studyType":22,"phases":276,"briefSummary":277,"conditions":278,"keywords":282,"overallStatus":285,"whyStopped":4,"lastUpdateSubmitDate":286,"lastUpdatePostDateStruct":287,"startDateStruct":289,"completionDateStruct":291,"leadSponsor":293,"locationsCount":45},"100643593","healthy-choices-to-reduce-stigma-and-improve-self-management-of-alcohol-and-hiv-among-young-adults-100643593","NCT07638618","Healthy Choices to Reduce Stigma and Improve Self-Management of Alcohol and HIV Among Young Adults","Inclusion Criteria:\n\n* Aged 18-29 years\n* Have HIV\n* Live in the Dominican Republic\n* Speak Spanish\n* Are unsuppressed\n* Report being stigmatized in the past 6 months\n* Report problem alcohol use in the past 6 months\n* Can provide informed consent\n\nExclusion Criteria:\n\n* Doe not meet the inclusion criteria.",{"count":275,"type":21},45,[24],"The Spanish language Healthy Choices intervention pilot study (N=45) holds direct relevance to the United States and federal priorities related to improving HIV outcomes to reduce transmission using implementation science models. If Healthy Choices is found to have a clinical signal of impact, our team is committed to testing the intervention in the United States and training Spanish speaking HIV care navigators on the intervention, specifically in the southern United States where Spanish speaking populations are concentrated, namely in Alabama, Texas, New Mexico, Arizona, Nevada, and Florida.",[279,280,281],"HIV","Alcohol Misuse","Stigma",[283,284],"Behavioral Intervention","Young Adults with HIV","NOT_YET_RECRUITING","2026-06-04",{"date":288,"type":37},"2026-06-10",{"date":290,"type":21},"2027-10-01",{"date":292,"type":21},"2029-02-28",{"name":43,"class":44},{"id":295,"slug":296,"hasResults":12,"nctId":297,"briefTitle":298,"officialTitle":299,"acronym":4,"eligibilityCriteria":300,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":301,"targetDuration":4,"studyType":22,"phases":303,"briefSummary":304,"conditions":305,"keywords":4,"overallStatus":285,"whyStopped":4,"lastUpdateSubmitDate":308,"lastUpdatePostDateStruct":309,"startDateStruct":311,"completionDateStruct":313,"leadSponsor":315,"locationsCount":45},"100638306","dual-language-b-more-for-hypertension-100638306","NCT07623031","Dual-Language B-MORE for Hypertension","B-MORE for Hypertension","Inclusion Criteria:\n\n* Age ≥18\n* Having self-reported hypertension (BP ≥ 140\u002F90)\n* Understanding English or Spanish instructions fluently\n\nExclusion Criteria:\n\n* Known or planned pregnancy in the next 3 months assessed via self-report\n* Cognitive impairment preventing completion of study procedures.\n* Have previous, formal mindfulness training (e.g., MBSR)\n* Other unstable illness judged by medical staff to interfere with study involvement.",{"count":302,"type":21},20,[24],"This pilot study is a single-arm clinical feasibility trial evaluating the feasibility, acceptability, and preliminary efficacy of a brief adaptation of Mindfulness-Oriented Recovery Enhancement (B-MORE) for reducing stress and high blood pressure in hypertensive English- and Spanish-speaking patients (n=20). The intervention, a 2-hour online training in stress management and hypertension, will be delivered virtually in a small-group format over two 60-minute sessions.",[306,307],"Hypertension (HTN)","Chronic Stress","2026-06-01",{"date":310,"type":37},"2026-06-03",{"date":312,"type":21},"2026-06",{"date":314,"type":21},"2026-12",{"name":43,"class":44},{"id":317,"slug":318,"hasResults":12,"nctId":319,"briefTitle":320,"officialTitle":321,"acronym":4,"eligibilityCriteria":322,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":323,"enrollmentInfo":324,"targetDuration":4,"studyType":22,"phases":325,"briefSummary":326,"conditions":327,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":331,"lastUpdatePostDateStruct":332,"startDateStruct":334,"completionDateStruct":335,"leadSponsor":336,"locationsCount":45},"100637872","safety-behavior-fading-versus-progressive-muscle-relaxation-for-appearance-concerns-100637872","NCT07589621","Safety Behavior Fading Versus Progressive Muscle Relaxation for Appearance Concerns","Safety Behavior Fading Versus Progressive Muscle Relaxation for Appearance Concerns: A Randomized Clinical Trial of Digital Interventions","Inclusion Criteria:\n\n* being between the ages of 18 and 65 years old\n* having an internet-capable smart-phone\n* scoring at or above the empirical cutoff for appearance concerns measured by the Social Appearance Anxiety Scale (i.e., 52)\n\nExclusion Criteria:\n\n* changes in psychotropic medication in the last 4 weeks\n* failing attention checks in baseline data collection","65 Years",{"count":20,"type":21},[24],"The current study aims to explore the efficacy of a text message based safety behavior fading intervention compared to a progressive muscle relaxation intervention for appearance concerns.",[328,329,330],"Body Dysmorphic Disorder","Eating Disorders","Social Anxiety Disorder","2026-05-29",{"date":333,"type":37},"2026-06-02",{"date":331,"type":37},{"date":314,"type":21},{"name":43,"class":44},{"id":338,"slug":339,"hasResults":12,"nctId":340,"briefTitle":341,"officialTitle":342,"acronym":343,"eligibilityCriteria":344,"healthyVolunteers":54,"sex":17,"minAge":345,"maxAge":4,"enrollmentInfo":346,"targetDuration":4,"studyType":126,"phases":4,"briefSummary":348,"conditions":349,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":351,"lastUpdatePostDateStruct":352,"startDateStruct":354,"completionDateStruct":356,"leadSponsor":358,"locationsCount":359},"100592631","medical-marijuana-and-open-road-driving-task-100592631","NCT06995937","Medical Marijuana and Open Road Driving Task","An Open Road Driving Performance Task to Examine Long-term Medical Marijuana Use and Prescription Opioid Positivity in Adults 50 and Older","ROADACE","Inclusion Criteria:\n\n* Age 50 and older who endorse chronic or severe non-malignant pain\n* Resident of Florida with an active and valid Florida Drivers License\n* Can communicate in English\n* Willing and able to complete study procedures\n* Have active medical marijuana card for \\>12 months issued by the state of Florida (MMG group) OR are race-sex match who has not used marijuana in the past 10 years with no history of daily use (NMG group)\n\nExclusion Criteria:\n\n* Have active psychosis\n* Have lost or revoked driving privileges\n* Score of below the cut 24 (out of 30) on the Montreal Cognitive Assessment (MoCA)\n* Are a control participant who urine test positive for marijuana use and\u002For reports any marijuana use in past 10 years","50 Years",{"count":347,"type":21},250,"Medical marijuana use among adults 50 and older has more than doubled in the past decade with exponential increases projected in this demographic by 2050, and prescription opioids are one of the most common treatments for pain management in this population. To date, no studies systematically assess driving performance in a rigorous and ecologically valid manner accounting for long-term medical marijuana use and\u002For the combined effect of prescription opioid use in adults 50 and older who endorse chronic or severe non-malignant pain. Further, studies examining how older adults self-regulate prescription medication use and driving behavior is limited, with none rigorously examining medical marijuana.",[350],"Medical Cannabis","2026-05-18",{"date":353,"type":37},"2026-05-20",{"date":355,"type":37},"2025-05-19",{"date":357,"type":21},"2029-01-30",{"name":43,"class":44},2,{"id":361,"slug":362,"hasResults":12,"nctId":363,"briefTitle":364,"officialTitle":364,"acronym":4,"eligibilityCriteria":365,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":323,"enrollmentInfo":366,"targetDuration":4,"studyType":22,"phases":368,"briefSummary":369,"conditions":370,"keywords":373,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":351,"lastUpdatePostDateStruct":377,"startDateStruct":378,"completionDateStruct":380,"leadSponsor":382,"locationsCount":45},"100557922","rapid-treatment-of-ptsd-with-accelerated-non-invasive-brain-stimulation-100557922","NCT06544408","Rapid Treatment of PTSD With Accelerated Non-Invasive Brain Stimulation","Inclusion:\n\n1. Adults age 18 years to 65 years old.\n2. Meets DSM-5 criteria for PTSD with a PCL-5 score \\> 33\n3. No changes in psychotropic medication (if taking psychotropic medication) and\u002For changes in supportive psychotherapy for 1 month prior to initial visit; and clinically appropriate to maintain stable treatment regimen for duration of trial.\n4. Clinically competent to give informed written consent and ability to understand study procedures and to comply with them for the entire length of the study\n\nExclusion:\n\n1. Medical contraindication for neuromodulation (e.g., ferrous metal in head, seizure disorder, brain tumor, stroke, aneurysm, multiple sclerosis, etc.).\n2. Active substance use disorder in last 3 months or any current substance use that puts the participant at increased risk or significant impairment.\n3. Dementia or other cognitive disorder making unable to engage in treatment.\n4. Any history or diagnosis of Schizophrenia, Schizoaffective Disorder, Delusional Disorder or other psychotic illness that precludes safe participation in trial.\n5. Suicidal risk that precludes safe participation defined as clinical impression that the participant is at significant risk for suicide.\n6. OCD cannot be the primary disorder but can have OCD symptoms.\n7. Inability to stop taking any medication that significantly lowers the seizure threshold (e.g., tricyclic antidepressants, clozapine, etc.)\n8. Current, planned, or suspected pregnancy\n9. Unstable medical conditions or any current medical condition that could preclude being able to safely participate in TMS treatment (e.g., unstable metabolic abnormality, unstable angina, etc.)\n10. Severe Traumatic Brain Injury\n11. We will exclude non-English speakers because of the need for rapid communication during the delivery of treatments.\n12. Significant ongoing litigation or claims that impact research activities, as determined by the research study team. (Research may especially be impacted when mental health or pain is being evaluated for litigation or claims, such as civil and criminal cases, disability claims and worker's compensation).\n13. Prior known active TMS of dorsolateral prefrontal cortex or dorsomedial prefrontal cortex or electroconvulsive therapy (ECT) -",{"count":367,"type":21},132,[24],"This study will test the clinical efficacy of an accelerated TMS (accel-TMS) protocol that rapidly addresses PTSD symptoms with 1 week (25 sessions over 5 days) of condensed treatment.",[371,372],"Post Traumatic Stress Disorder","Traumatic Brain Injury",[374,375,376],"PTSD","TMS","Transcranial Magnetic Stimulation",{"date":353,"type":37},{"date":379,"type":37},"2024-11-06",{"date":381,"type":21},"2028-12-30",{"name":43,"class":44},{"id":384,"slug":385,"hasResults":12,"nctId":386,"briefTitle":387,"officialTitle":388,"acronym":4,"eligibilityCriteria":389,"healthyVolunteers":12,"sex":17,"minAge":390,"maxAge":391,"enrollmentInfo":392,"targetDuration":4,"studyType":22,"phases":394,"briefSummary":395,"conditions":396,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":398,"lastUpdatePostDateStruct":399,"startDateStruct":401,"completionDateStruct":403,"leadSponsor":404,"locationsCount":45},"100615771","youth-emotional-and-behavioral-treatment-study-100615771","NCT07296939","Youth Emotional and Behavioral Treatment Study","Psychological Assessment and Treatment of Youth Emotional and Behavioral Dysregulation","Inclusion Criteria:\n\n* Children between the ages of 4-17 years\n* (a) a principal diagnosis of an anxiety or mood disorder per DSM-5 criteria, OR (b) parent report of clinically impairing irritability, emotional dysregulation, and\u002For disruptive behavior in youth\n* Child and parent must be able to complete consent documents, assessments, and participate in treatment in English without a translator\n* At least one parent must be available and willing to participant in both phases.\n\nExclusion Criteria:\n\n* Gross neurological, sensory, or motor impairment\n* History of seizure disorder, psychosis, or organic brain syndrome\n* Conditions requiring acute intervention, e.g., active suicidality\n* Non-English speaking child or parent","4 Years","17 Years",{"count":393,"type":21},500,[24],"This study aims to characterize key mechanisms underlying the development, maintenance, and treatment of severe irritability in a clinically heterogeneous sample of school-aged youth.",[397],"Depression, Anxiety","2026-05-12",{"date":400,"type":37},"2026-05-14",{"date":402,"type":37},"2026-05-07",{"date":153,"type":21},{"name":43,"class":44},{"id":406,"slug":407,"hasResults":12,"nctId":408,"briefTitle":409,"officialTitle":410,"acronym":4,"eligibilityCriteria":411,"healthyVolunteers":12,"sex":17,"minAge":412,"maxAge":413,"enrollmentInfo":414,"targetDuration":4,"studyType":22,"phases":416,"briefSummary":417,"conditions":418,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":420,"lastUpdatePostDateStruct":421,"startDateStruct":422,"completionDateStruct":424,"leadSponsor":426,"locationsCount":45},"100477089","central-executive-training-and-parent-training-for-adhd-100477089","NCT05492422","Central Executive Training and Parent Training for ADHD","Evaluating the Efficacy of Sequenced Central Executive and Behavioral Parent Training for Children With ADHD","Inclusion:\n\n1. Children ages 8-12 with principal ADHD diagnoses (via K-SADS); and\n2. parent AND teacher ratings in clinical\u002Fborderline range based on age and sex on ADHD Rating Scale (ADHD-5) or Behavior Assessment Scale for Children (BASC-3) Attention Problems\u002FHyperactivity subscales (i.e., 90th percentile or higher based on both informants).\n\nAll DSM-5 ADHD presentations will be eligible.\n\nExclusion:\n\n1. gross neurological, sensory, or motor impairment;\n2. history of seizure disorder, psychosis, bipolar, or severe dysregulation disorders that may interfere with participation (e.g., disruptive mood dysregulation, intermittent explosive, reactive attachment, substance use);\n3. intellectual disability or Wechsler Intelligence Scale for Children (WISC-V) short-form standard score \\\u003C70;\n4. conditions requiring acute intervention, e.g., active suicidality; and\n5. non-English speaking child or parent.","8 Years","12 Years",{"count":415,"type":21},200,[24],"The goal of the current project is to combine two evidence- based treatments for school-aged children with ADHD: Central Executive Training (CET) and Behavioral Parent Training (BPT). CET is a computerized training intervention that improves ADHD symptoms and academic functioning by improving children's working memory abilities. BPT is a therapeutic intervention that improves family functioning and child oppositional-defiant (ODD) symptoms by changing parenting behaviors. Their combined use is expected to provide complementary and additive benefits, particularly if CET is delivered before BPT.",[419],"ADHD","2026-05-05",{"date":402,"type":37},{"date":423,"type":37},"2022-10-03",{"date":425,"type":21},"2027-08-01",{"name":43,"class":44},{"id":428,"slug":429,"hasResults":12,"nctId":430,"briefTitle":431,"officialTitle":432,"acronym":4,"eligibilityCriteria":433,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":323,"enrollmentInfo":434,"targetDuration":4,"studyType":22,"phases":435,"briefSummary":436,"conditions":437,"keywords":441,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":444,"lastUpdatePostDateStruct":445,"startDateStruct":447,"completionDateStruct":449,"leadSponsor":451,"locationsCount":45},"100623006","text-message-safety-behavior-fading-for-pathological-worry-100623006","NCT07391020","Text Message Safety Behavior Fading for Pathological Worry","Safety Behavior Fading Intervention for Pathological Worry","Inclusion Criteria:\n\n\\- Elevated worry as defined by a score of 60 or higher on the PSWQ.\n\nExclusion Criteria:\n\n* Score of 59 or lower on the PSWQ\n* If applicable, unstable psychiatric medication usage any time over the past 4 weeks\n* Failing attention checks in baseline data collection\n* Pregnancy",{"count":20,"type":21},[24],"The current study aims to explore the efficacy of a text message-based Safety Behavior Fading Intervention compared to a PMR control condition.",[438,439,440],"Generalized Anxiety Disorder (GAD)","Worrying","Anxiety",[442,443],"safety behaviors","worry","2026-04-28",{"date":446,"type":37},"2026-04-30",{"date":448,"type":37},"2026-03-01",{"date":450,"type":21},"2027-02",{"name":43,"class":44},{"id":453,"slug":4,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":4,"eligibilityCriteria":16,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":454,"targetDuration":4,"studyType":22,"phases":455,"briefSummary":25,"conditions":456,"keywords":4,"overallStatus":285,"whyStopped":4,"lastUpdateSubmitDate":457,"lastUpdatePostDateStruct":458,"startDateStruct":460,"completionDateStruct":461,"leadSponsor":462,"locationsCount":45},"100636186",{"count":20,"type":21},[24],[27,28,29,30,31,32],"2026-04-27",{"date":459,"type":37},"2026-05-01",{"date":459,"type":21},{"date":41,"type":21},{"name":43,"class":44},{"id":464,"slug":465,"hasResults":12,"nctId":466,"briefTitle":467,"officialTitle":468,"acronym":469,"eligibilityCriteria":470,"healthyVolunteers":54,"sex":471,"minAge":472,"maxAge":4,"enrollmentInfo":473,"targetDuration":4,"studyType":22,"phases":475,"briefSummary":476,"conditions":477,"keywords":4,"overallStatus":285,"whyStopped":4,"lastUpdateSubmitDate":481,"lastUpdatePostDateStruct":482,"startDateStruct":483,"completionDateStruct":485,"leadSponsor":487,"locationsCount":4},"100525913","learning-early-infant-feeding-cues-100525913","NCT06127914","Learning Early Infant Feeding Cues","A Multiphase Project to Improve Use of Responsive Feeding Among Vulnerable Mother-Infant Dyads","LEIFc","Maternal Inclusion Criteria\n\n* Pregnant mother in the 3rd trimester (28 weeks or beyond)\n* Enrolled in a government-funded maternal-child home visiting program\n* Maternal age 18 years or older\n* English or Spanish speaking\n* Anticipated to have custody of infant after birth\n* Healthy pregnancy, no complications that are anticipated to result in a preterm birth or extended hospital stay for mother or infant\n\nMaternal Exclusion Criteria\n\n* Gave birth to multiple fetuses\n* Age less than 18 years\n* Not fluent in English or Spanish\n* Expected to not have custody of the infant after birth\n\nInfant inclusion criteria\n\n* Born as a singleton (not a twin, triplet, etc.) to a mother enrolled in a maternal-child home visiting program\n* Born full term (37 weeks or beyond)\n\nInfant exclusion criteria\n\n* Congenital anomaly that may interfere with infant feeding or growth after birth (i.e., Down Syndrome, cleft lip\u002Fpalate)\n* Born preterm (born prior to 37 weeks)\n* NICU stay beyond 48 hours\n* Infant diagnosis of failure to thrive\n* Supplemental oxygen\n* Enteral feeding device used for feedings","FEMALE","2 Weeks",{"count":474,"type":21},39,[24],"The goal of this clinical trial is to learn more about responsive infant feeding (recognizing baby's signs of hunger and fullness) in mothers and infant enrolled in government-funded maternal-child home visiting programs. The main questions it aims to answer are:\n\n* What are the contributors and barriers to use of responsive infant feeding?\n* How can we refine an intervention focused on responsive infant feeding (the Learning Early Infant Feeding Cues intervention) so that mothers will like it and learn skills to help their baby be healthy.\n* Will the refined intervention improve use of responsive feeding and be feasible and acceptable to mothers and home visiting programs?\n\nParticipants will be asked to:\n\n* Participate in focus groups to talk about their experiences feeding their baby.\n* Participate in a study to learn about responsive feeding and how to use it with their baby. This study will start when mothers are in their final month of pregnancy and finish when their baby is 6 months old. Participation will include:\n\n  * Having someone come to the family home during a time when the baby is eating (either from the breast or the bottle). The mother will receive information on the baby's signs from an experienced coach.\n  * Agreeing to be video recording during the session when the baby is eating.\n  * Completing surveys online.",[478,479,480],"Responsive Feeding","Infants","Weight Gain Trajectory","2026-04-22",{"date":457,"type":37},{"date":484,"type":21},"2027-07-01",{"date":486,"type":21},"2029-06-30",{"name":43,"class":44},{"id":489,"slug":490,"hasResults":12,"nctId":491,"briefTitle":492,"officialTitle":493,"acronym":4,"eligibilityCriteria":494,"healthyVolunteers":54,"sex":17,"minAge":18,"maxAge":78,"enrollmentInfo":495,"targetDuration":4,"studyType":22,"phases":497,"briefSummary":498,"conditions":499,"keywords":500,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":501,"lastUpdatePostDateStruct":502,"startDateStruct":504,"completionDateStruct":505,"leadSponsor":507,"locationsCount":45},"100609966","sodium-vs-potassium-education-to-improve-vascular-health-100609966","NCT07221448","Sodium vs Potassium Education to Improve Vascular Health","Improving Vascular Health Using Nutrition Education Aimed At Increasing Potassium Intake Versus Reducing Sodium Intake","Inclusion Criteria:\n\n* Willing and able to attend in-person laboratory visits\n* Usual sodium intake ≥3,000 mg\u002Fd for females and ≥4,000 mg\u002Fd for males\n* Usual potassium intake ≤2,500 mg\u002Fd in females and ≤3,000 mg\u002Fd in males\n\nExclusion Criteria:\n\n* BMI ≥35 kg\u002Fm2\n* Seated blood pressure ≥130\u002F80 mmHg\n* Current diagnosis or history of diabetes, renal disease, cancer, cardiovascular disease, or major cardiovascular event (e.g. heart attack or stroke)\n* Current or recent use of a diuretic (within the past 6 months)\n* Elevated blood lipids (LDL cholesterol ≥190 mg\u002FdL)\n* Elevated serum potassium level (\\>5.1 mmol\u002FL)\n* Elevated BUN (\\>22 mg\u002FdL)\n* Elevated creatinine (\\>1.2 mg\u002FdL)\n* Low eGFR (\\\u003C90 mL\u002Fmin\u002F1.73 m²)\n* Current or recent use of tobacco, nicotine, or illicit drugs\n* Radical hysterectomy or oophorectomy (females)\\*\n* Pregnant or lactating\n* Following a weight-loss diet, or intending to gain or lose weight during the study period",{"count":496,"type":21},32,[24],"The goal of this clinical trial is to determine if a self-selected high potassium diet is easier to achieve and more effective at improving vascular health than a low sodium diet in generally healthy young adults who typically consume more than the recommended amount of sodium. The main questions it aims to answer are:\n\n1. Is it easier for young adults to increase their potassium intake, rather than reduce their sodium intake?\n2. Is a self-selected high potassium diet better at improving vascular health compared to a self-selected low sodium diet?\n\nResearchers will compare the effectiveness of an education-based intervention centered only on increasing dietary potassium intake against an education-based intervention centered only on reducing dietary sodium intake.\n\nParticipants will be randomly assigned to receive comprehensive dietary education on adopting either a high-potassium diet or a low-sodium diet.\n\nEducation will be delivered in four weekly one-on-one sessions. Following the four-week education period, participants will be encouraged to change their diet based on what they have learned. Measures of dietary compliance (urine samples and diet records) and cardiovascular health (blood pressure, endothelial function) will be assessed at two, four, and six months post-education.",[129],[209,210,181,211,212],"2026-04-20",{"date":503,"type":37},"2026-04-23",{"date":501,"type":37},{"date":506,"type":21},"2027-09-30",{"name":43,"class":44},{"id":509,"slug":510,"hasResults":12,"nctId":511,"briefTitle":512,"officialTitle":512,"acronym":513,"eligibilityCriteria":514,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":515,"targetDuration":4,"studyType":22,"phases":517,"briefSummary":518,"conditions":519,"keywords":520,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":525,"lastUpdatePostDateStruct":526,"startDateStruct":528,"completionDateStruct":530,"leadSponsor":532,"locationsCount":45},"100505483","smarter-weight-loss-management-100505483","NCT05861973","SMARTer Weight Loss Management","SMARTer","Inclusion Criteria:\n\n* Over 18 years old\n* BMI of ≥25, weight \\\u003C396 lbs\n* Must own a Smartphone, and be willing to install the SMARTer app\n* Not enrolled in a formal weight loss program\n\nExclusion Criteria:\n\n* Cerebrovascular accident or myocardial infarction within six months of enrollment\n* Diabetes treated with insulin\n* Pregnancy, lactation or intended pregnancy\n* Active suicidal ideation\n* Anorexia or bulimia\n* Requiring an assistive device for mobility\n* Taking weight loss medications, such as GLP-1 agonists",{"count":516,"type":21},492,[24],"The SMARTer trial will be a three-arm, randomized controlled non-inferiority trial that compares the optimized, adaptive SMARTer intervention, fixed DPP, and Self-Guided (Control). The trial will address whether a scalable, stepped-care intervention can stand up to gold-standard DPP by achieving comparable weight loss at a lower cost. Alongside evaluation of clinical non-inferiority, a comprehensive economic evaluation will inform relative affordability. Cost information is important to inform treatment policy and change standard of care, but is sorely lacking for behavioral interventions. The SMARTer intervention reduces costs by initially offering minimal intervention to all and stepping up to offer more costly treatment components only to non-responders who fail to attain the target weight loss. A rigorous economic evaluation planned and designed alongside the SMARTer trial will provide an accurate, robust head-to-head comparison of costs, cost-effectiveness, and projected lifetime health care costs between the three arms.",[84],[521,522,523,524],"stepped care","adaptive intervention","non-inferiority trial","behavioral obesity treatment","2026-04-10",{"date":527,"type":37},"2026-04-15",{"date":529,"type":37},"2024-06-25",{"date":531,"type":21},"2027-10-31",{"name":43,"class":44},{"id":534,"slug":535,"hasResults":12,"nctId":536,"briefTitle":537,"officialTitle":538,"acronym":4,"eligibilityCriteria":539,"healthyVolunteers":54,"sex":17,"minAge":162,"maxAge":163,"enrollmentInfo":540,"targetDuration":4,"studyType":22,"phases":541,"briefSummary":542,"conditions":543,"keywords":544,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":551,"lastUpdatePostDateStruct":552,"startDateStruct":554,"completionDateStruct":556,"leadSponsor":558,"locationsCount":45},"100586558","effect-of-peanut-butter-on-gut-and-metabolic-health-100586558","NCT06916936","Effect of Peanut Butter on Gut and Metabolic Health","Effect of Peanut Butter on Gut and Metabolic Health in School-Aged Children","Inclusion Criteria:\n\n* Enrolled in elementary or middle school (grades 1-8)\n* Aged 6-13 years old\n* Ability to speak and read in English\n\nExclusion Criteria:\n\n* Intake of antibiotics in the last 3 months\n* Intake of pre\u002Fpro\u002Fpostbiotics in the last 3 months\n* Food allergy to study foods\n\n  * Any allergy to nuts or peanuts\n* Any allergy to the isocaloric snack (chocolate or wheat)\n* Regular consumption of nuts or peanuts greater than 2 servings \u002F week\n* Gastrointestinal disease (ulcerative colitis, Crohn's disease, diverticulosis, peptic ulcers, small intestinal bacterial overgrowth, short bowel syndrome, irritable bowel syndrome, gastroesophageal reflux disease), neurological (multiple sclerosis, meningitis, recent stroke) or endocrine disorders (uncontrolled thyroid disorders, growth hormone disorders, adrenal gland disorders, uncontrolled diabetes - A1C \\> 9%).\n* Known to be pregnant (self-disclosed)",{"count":165,"type":21},[24],"The goal of this is parallel arm, randomized clinical trial is to learn and understand the effect of daily smooth peanut butter consumption on gut and metabolic health of children age 6-13. The main objectives are:\n\nPrimary Objective: To determine the prebiotic effect of daily smooth peanut butter consumption for eight weeks on gut health, including microbiome-metabolome arrays, gut epithelial\u002Fbarrier function, and gut transit time, in school-aged children.\n\nSecondary Objective(s)\n\n1. To determine the effect of daily smooth peanut butter consumption for eight weeks on metabolic and inflammatory health markers, and measures of sleep quality in school-aged children.\n2. To determine the potential mechanisms and feasibility of incorporating peanut butter into the diets of school-aged children as part of healthy, personalized nutrition.\n\nResearch Intervention(s): Researchers compare two groups to see if there really is an effect of daily smooth peanut butter intake on gut and metabolic health. The two groups are:\n\n1. The 1st condition (PB) includes a normal diet supplemented daily with personalized portion of smooth PB, sandwiched between two plain unsalted saltine crackers.\n2. The 2nd condition (CTL) includes a normal diet supplemented daily with an isocaloric amount of a nut-free, vegetable oil-based chocolate spread, sandwiched between two plain unsalted saltine crackers.",[169],[545,174,234,546,547,548,549,232,550,176],"microbiome","peanut butter","metabolic health","dysbiosis","metagenomic","prebiotic","2026-04-08",{"date":553,"type":37},"2026-04-09",{"date":555,"type":37},"2025-02-09",{"date":557,"type":21},"2027-05",{"name":43,"class":44},{"id":560,"slug":561,"hasResults":12,"nctId":562,"briefTitle":563,"officialTitle":564,"acronym":4,"eligibilityCriteria":565,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":566,"enrollmentInfo":567,"targetDuration":4,"studyType":22,"phases":569,"briefSummary":570,"conditions":571,"keywords":573,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":551,"lastUpdatePostDateStruct":582,"startDateStruct":583,"completionDateStruct":585,"leadSponsor":586,"locationsCount":45},"100561288","effect-of-watermelon-on-gut-and-cardiometabolic-health-100561288","NCT06588218","Effect of Watermelon on Gut and Cardiometabolic Health","Effect of Daily Fresh Watermelon Consumption on Gut and Cardiometabolic Health in Young Adults With Overweight and Obesity","Inclusion Criteria:\n\n* Between 18 and 30 years old\n* Ability to speak and read in English\n* Overweight or Obese Class 1 and 2 (BMI ≥ 25 - 39.9 kg\u002Fm2)\n\nExclusion Criteria:\n\n* Intake of antibiotics in the last 3 months\n* Intake of pre\u002Fpro\u002Fpostbiotics in the last 3 months\n* Current or past (within the last 6 months) user of tobacco, marijuana, or E-cigarette products\n* Cardiovascular disease (will not exclude for hypertension), gastrointestinal disease (ulcerative colitis, celiac, Crohn's disease, diverticulosis, peptic ulcers, small intestinal bacterial overgrowth, short bowel syndrome), neurological (multiple sclerosis, meningitis, recent stroke) or endocrine disorders (uncontrolled thyroid disorders, growth hormone disorders, adrenal gland disorders, uncontrolled diabetes - A1C greater than 9%).\n* Food allergy to study foods\n* Any allergy to melon\n* Any allergy to the isocaloric snack (gluten)\n* Regular consumption of watermelon greater than 2 servings \u002F week\n* Current heavy alcohol use (≥ 15 drinks \u002F week for men, ≥ 8 drinks \u002F week for women\n* Class 3 Obesity (BMI \\> 40 kg\u002Fm2)\n* Current user of Citrulline, Arginine, Nitric Oxide or other supplements known to affect nitric oxide synthesis (beet root juice or any beet supplement, Pycnogenol \u002F Pine bark extract)\n* Known to be currently pregnant (self-disclosed)","30 Years",{"count":568,"type":21},36,[24],"The goal of this clinical trial is to evaluate the effect of daily fresh watermelon consumption for 6-weeks on gut health, including microbiome diversity, gut barrier and immune function in young adults with overweight and obesity. The main questions it aims to answer are:\n\n1. Will consuming fresh watermelon daily for 6-weeks will improve intestinal barrier health and increase microbiome diversity such as an increased population of beneficial 'probiotic' bacteria when compared to control participants consuming a low-fat snack?\n2. Will consuming fresh watermelon daily for six-weeks will improve other health measures, including body-composition, blood pressure, blood vessel function, blood lipid profiles, and measures of inflammation, as compared to control participants consuming a low-fat snack for the same time period?",[572,169],"Obesity and Overweight",[574,169,575,576,84,577,578,579,580,581],"Gut Microbiome","Diet","Overweight","Watermelon","Lycopene","Citrulline","Metagenomic","vascular",{"date":553,"type":37},{"date":584,"type":37},"2024-10-13",{"date":314,"type":21},{"name":43,"class":44},{"id":588,"slug":589,"hasResults":12,"nctId":590,"briefTitle":591,"officialTitle":592,"acronym":4,"eligibilityCriteria":593,"healthyVolunteers":12,"sex":471,"minAge":345,"maxAge":202,"enrollmentInfo":594,"targetDuration":4,"studyType":22,"phases":596,"briefSummary":597,"conditions":598,"keywords":601,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":605,"lastUpdatePostDateStruct":606,"startDateStruct":608,"completionDateStruct":610,"leadSponsor":611,"locationsCount":45},"100466264","exercise-training-and-fat-metabolism-in-postmenopausal-women-100466264","NCT05351476","Exercise Training and Fat Metabolism in Postmenopausal Women","Resistance Training Modulation of Fat Metabolism in Obese Postmenopausal Women","Inclusion Criteria:\n\n* Women\n* Postmenopausal (50-75 yrs.)\n* Obese (BMI 30-50 kg\u002Fm2)\n* Prediabetes (HbA1c 5.7 - 6.4% or fasting blood glucose 100 to 125 mg\u002FdL, or 2hr OGTT blood glucose 140 to 199 mg\u002FdL)\n* Sedentary (not performing purposeful exercise training more than 20 minutes per day twice a week)\n* Non-smokers\n* No hormone replacement therapy for at least the past two years.\n\nExclusion Criteria:\n\n* Engaging in purposeful resistance training or endurance training (\\> 20min\u002Fday, \\> 2 days\u002Fweek)\n* Resting blood pressure above 140 mmHg systolic or 90 mmHg diastolic\n* Type 1 or type 2 diabetes\n* Medical problems in which exercise is contraindicated, such as chronic infections\n* History of, or currently presentation with, cancer, cardiovascular or respiratory disease\n* Uncontrolled thyroid dysfunction, liver or renal dysfunction\n* Taking any medication affecting lipid metabolism\n* Musculoskeletal disease or injury that would otherwise prevent engagement in resistance and endurance training\n* Smokers and those with diagnosed eating disorders",{"count":595,"type":21},120,[24],"Adipose tissue turnover plays a critical role in body weight maintenance, and obesity is underscored by the dysregulated balance between fat breakdown and synthesis. Although there are clear health-related benefits of physical activity, little is known about how resistance exercise, as opposed to endurance exercise, can reduce the risk of metabolic disorders, particularly in women. The goal of the proposed study is to investigate the effectiveness of resistance training to improve basal and stimulated fat metabolism in postmenopausal women with obesity and pre-diabetes, potentially serving as a viable and practical approach to prevent the onset of type 2 diabetes.",[599,84,600],"Postmenopausal Symptoms","Prediabetic State",[602,603,604],"Resistance Exercise","Fat Metabolism","Postmenopause","2026-04-07",{"date":607,"type":37},"2026-04-13",{"date":609,"type":37},"2022-05-20",{"date":41,"type":21},{"name":43,"class":44},""]