[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Fondation Ellen Poidatz\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":112},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,41,70,89],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":40},"100614918","intensive-rehabilitation-program-for-upper-limb-in-children-and-adolescents-with-cerebral-palsy-100614918",false,"NCT07285837","Intensive Rehabilitation Program for Upper Limb in Children and Adolescents With Cerebral Palsy","Effect of an Intensive Rehabilitation Protocol Combining Constraint-Induced Movement Therapy and Bimanual Training on Upper Limb Use and Gross Motor Function in Children and Adolescents With Cerebral Palsy","Inclusion Criteria:\n\n* A clinical diagnosis of CP mentioned in the medical record\n* Aged between 3 and 17 years inclusive (\\\u003C18 years)\n* Global Motor Function Classification System (GMFCS) and Manual Ability Classification System (MACS) levels I to IV\n* Ability to cooperate, understand and follow simple instructions\n* Patient affiliated to the French social security system\n* Voluntary patient whose parents have given their consent for their child to participate in the study.\n\nExclusion Criteria:\n\n* Presence of injuries incompatible with participation in the program, or pain rated \\>3 on the Visual Analogue Scale (VAS)\n* Presence of behavioral disorders\n* History of botulinum toxin injections or surgical intervention within six months prior to study enrollment.","ALL","3 Years","17 Years",{"count":20,"type":21},90,"ESTIMATED","INTERVENTIONAL",[24],"NA","Cerebral palsy is the most common motor disability in children. Individuals with CP often experience significant difficulties in the use of their upper limbs, which affects their autonomy and quality of life. Conventional rehabilitation, although essential, is often insufficient to compensate for these deficits in a meaningful way.\n\nThe French National Authority for Health has issued recommendations for intensifying rehabilitation in order to maximize functional gains in children with CP. Among the intensive approaches that have been studied, two techniques have demonstrated efficacy: Constraint-Induced Movement Therapy (CIMT) and Bimanual Intensive Therapy (BIT).\n\nCIMT focuses on restricting the use of the unaffected limb to encourage the use of the affected limb, thereby promoting neuroplasticity and functional improvement. In contrast, BIT emphasizes intensive training of both hands simultaneously to enhance coordination and overall upper limb functionality.\n\nAt the Ellen Poidatz Foundation, an intensive rehabilitation program has been developed that combines these two complementary approaches. This program, which is already in place, is based on the principles of neuromotor rehabilitation and motor learning. It integrates several methods recommended by the HAS, including Bimanual Intensive Therapy (BIT) such as HABIT (Grade A) or HABIT-ILE (Grade B), Modified Constraint-Induced Movement Therapy (mCIMT) (Grade B), and Adapted Physical Activity (APA) (Grade A).\n\nThe aim of this intensive program is to enhance the functional use of the upper limb by improving bimanual coordination, grasping, manipulation, and overall motor function. The program lasts 10 days over a 2-week period and is tailored to the child's age and care setting. It includes approximately 60 hours of rehabilitation for children aged 3 to 8 years and 80 hours for those aged 9 to 17 years, in line with current international recommendations.\n\nThe aim of this study is to evaluate the effectiveness of this existing intensive rehabilitation program in improving manual abilities in children with CP. Specifically, the study seeks to objectively assess the benefits of the Habil'Hand+ program and to contribute to the optimization of rehabilitation protocols for this population.",[27],"Cerebral Palsy (CP)","RECRUITING","2026-01-27",{"date":31,"type":32},"2026-01-29","ACTUAL",{"date":34,"type":32},"2025-11-21",{"date":36,"type":21},"2030-12",{"name":38,"class":39},"Fondation Ellen Poidatz","OTHER",1,{"id":42,"slug":43,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":4,"eligibilityCriteria":47,"healthyVolunteers":11,"sex":16,"minAge":48,"maxAge":49,"enrollmentInfo":50,"targetDuration":4,"studyType":22,"phases":52,"briefSummary":53,"conditions":54,"keywords":57,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":40},"100426753","serious-game-based-intervention-in-gait-rehabilitation-for-children-with-cerebral-palsy-100426753","NCT04837105","Serious Game-based Intervention in Gait Rehabilitation for Children With Cerebral Palsy","Serious Game-based Intervention in Gait Rehabilitation for Children With Cerebral Palsy: Randomized Control Trial","Inclusion Criteria:\n\n* A clinical diagnosis of CP mentioned in the medical record\n* Minor child for the entire duration of the protocol, i.e. between 10 and 17 years of age (the child must be less than 18 years of age at the time of the last check-up scheduled 1 year after inclusion in the study)\n* Global Motor Function Classification System (GMFCS) levels I to III\n* Functional Mobility Scale 50 meters rating superior or equal to 2 (ability to walk on 50m using a walker or frame without help from another person)\n* Ability to cooperate, understand and follow simple instructions to play.\n* Patient affiliated to the French social security system\n* Voluntary patient whose parents have given their consent for their child to participate in the study\n* Patient who has undergone multisite surgery of the lower limbs including bone procedures at least 7 weeks before the start of the procedure\n\nExclusion Criteria:\n\n* A diagnosis of photosensitive epilepsy mentioned in the medical file AND\u002FOR a mention in the child's medical file or by the parents or by the child of a history of epileptic seizures occurring during the practice of a video game\n* A visual, cognitive or auditory impairment at a level that would interfere with playing the game. The patient must have normal or corrected vision and hearing.","10 Years","18 Years",{"count":51,"type":21},14,[24],"Cerebral palsy (CP) is defined as a group of movement and posture disorders that cause activity limitation due to brain damage during fetal development or in the first year of life. Motor activities, and in particular walking, can be affected by many factors including sensory deficits, biomechanical and postural limitations, muscle weakness and spasticity. Theories of gait training guide rehabilitation management strategies. Among these, intensification, variability and specific training of walking parameters (speed, step length, cadence) have shown their effectiveness. Delivering sensory feedback during gait rehabilitation exercises is a complementary approach to improve motor learning during rehabilitation. On the other hand, motivation is a key factor in the success of rehabilitation. The addition of walking exercises performed through a serious game in augmented reality (AR) appears relevant for the rehabilitation of children with CP after surgery.\n\nThe serious game ARRoW-CP is based on the latest advances in the literature in terms of gait rehabilitation protocol but also on the results of a clinical study conducted by our team, to identify the best feedback modalities to be delivered during the serious rehabilitation game.",[55,56],"Cerebral Palsy","Gait Disorders, Neurologic",[58,59,60,61],"physiotherapy","gait rehabilitation","serious game","multi level surgery","2025-08-19",{"date":64,"type":32},"2025-08-24",{"date":66,"type":32},"2021-04-15",{"date":68,"type":21},"2025-12-31",{"name":38,"class":39},{"id":71,"slug":72,"hasResults":11,"nctId":73,"briefTitle":74,"officialTitle":75,"acronym":4,"eligibilityCriteria":76,"healthyVolunteers":77,"sex":16,"minAge":78,"maxAge":49,"enrollmentInfo":79,"targetDuration":4,"studyType":22,"phases":81,"briefSummary":82,"conditions":83,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":84,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":88,"locationsCount":40},"100408313","protocol-validation-of-dynamometric-measurement-of-passive-inter-segmental-stiffness-and-spasticity-in-children-with-cerebral-palsy-100408313","NCT04596852","Protocol Validation of Dynamometric Measurement of Passive Inter-segmental Stiffness and Spasticity in Children With Cerebral Palsy","Protocol Validation of Dynamometric Measurement of Passive Inter-segmental Stiffness and Spasticity in Children With Cerebral Palsy: (DYNA_PC)","The inclusion criteria for PC children are :\n\n* A clinical diagnosis of CP noted in the medical record\n* An age between 7 and 18 years old\n* Levels I to III for the Global Motor Function Classification System (GMFCS)\n* Ability to cooperate, understand and follow simple instructions\n* Patient affiliated to the French social security system\n* Voluntary patient whose parents have given their consent to participate\n\nThe inclusion criteria for healthy children are :\n\n* An age between 7 and 18 years old\n* Ability to cooperate, understand and follow simple instructions\n* Patient affiliated to the French social security system\n* Voluntary patient whose parents have given their consent to participate\n\nExclusion Criteria:\n\n* Medical decision for any reason\n* Child or parent decision for any reason\n* Inability to cooperate, to understand and to follow instructions\n* Surgery or botulinum toxin injection within 6 months prior to the start of the study.\n* A diagnosis of a form of dystonia.",true,"7 Years",{"count":80,"type":21},85,[24],"Cerebral palsy (CP) refers to a group of movement and posture disorders responsible for activity limitation due to brain damage that occurs during fetal development or during the first year of a child's life.\n\nGiven the multitude of treatment options available, the choice of treatment is a key determinant that greatly influences the potential for improvement in motor function. This choice is based in particular on a diagnosis resulting from the comparison of a Clinical Gait Analysis (CGA) and a clinical examination, carried out by a practitioner, aimed at evaluating as accurately as possible the deficiencies present in children with CP.\n\nDuring the latter examination, passive inter-segmental stiffness and spasticity, both limiting factors in the mobility of the child with CP, are assessed. However, there are significant uncertainties in these measurements, which depend, among other things, on the examiner's feelings. The enrichment of this clinical assessment therefore requires the introduction of quantitative and objective measures. Portable dynamometers are increasingly used to measure the resistance of a joint during passive solicitations.\n\nThus, both passive inter-segmental stiffness and spasticity can be characterized using instrumental methods. However, in the majority of studies proposed in the literature, the biomechanical computational model used is not unified with that of the CGA, thus altering the approximation of the parameters measured on the table with those estimated during gait. However, in order to evaluate the extent to which these phenomena occur during gait, it is important to follow the same biomechanical calculation procedure.\n\nThus, our team proposes a new dynamometric measurement protocol for passive inter-segmental stiffness and spasticity adapted to the PC child. Nevertheless, in order to guarantee the reliability of the measurements, manual dynamometric solicitation methods must follow standardized protocols, and their psychometric properties must be defined before they can be used in clinical practice. This is why we wish to study the reliability of this new solution for dynamometric quantification of passive inter-segmental stiffness and spasticity in children with CP.",[55],{"date":64,"type":32},{"date":86,"type":32},"2020-11-02",{"date":68,"type":21},{"name":38,"class":39},{"id":90,"slug":91,"hasResults":11,"nctId":92,"briefTitle":93,"officialTitle":94,"acronym":4,"eligibilityCriteria":95,"healthyVolunteers":11,"sex":16,"minAge":96,"maxAge":18,"enrollmentInfo":97,"targetDuration":4,"studyType":22,"phases":99,"briefSummary":100,"conditions":101,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":103,"lastUpdatePostDateStruct":104,"startDateStruct":106,"completionDateStruct":108,"leadSponsor":110,"locationsCount":111},"100582701","effect-of-using-an-object-handling-serious-game-on-upper-limb-rehabilitation-for-children-with-neurological-disorders-100582701","NCT06866730","Effect of Using an Object Handling Serious Game on Upper Limb Rehabilitation for Children with Neurological Disorders","Effect of Intensive Repetitive Motor Training in Toy Manipulation Supported by Gamified Physical Training Software in Children and Adolescents with Neurological Disorders Impacting Motor Skills","Inclusion Criteria:\n\n* Neurological disorder causing motor impairment\n* Age 4 to 17 years old\n* MACS level I to III\n* Ability to cooperate, understand, and follow simple instructions to play the game.\n* Patient affiliated with the French social security system.\n* Voluntary patient whose parents have given consent for their child to participate in the study.\n\nExclusion Criteria:\n\n* A diagnosis of photosensitive epilepsy mentioned in the medical record AND\u002FOR a note in the child's medical record or reported by the parents of a history of seizures triggered by video game use.\n* Botulinum toxin treatment within the 3 months prior to the study or intensive rehabilitation of manual skills (e.g., mCIMT, HABIT, etc.).\n* Sensory and\u002For cognitive impairments that would interfere with playing the game.","4 Years",{"count":98,"type":21},10,[24],"Cerebral palsy, and more broadly neurological disorders, can lead to significant motor impairments that impact individuals' daily lives. To address these limitations, the French National Authority for Health has issued recommendations for rehabilitative care, highlighting intensive training programs, physical activity, and interactive computer games. Scientific literature has also demonstrated the benefits of therapies that incorporate repetition.\n\nIn this study, the investigators aimed to train patients in producing grasp-and-release movements, and more broadly \\*reach-to-grasp\\* actions, in a manner intensified by movement repetition. To mitigate the boredom inherent to such repetitive tasks, the invesigators developed a device resembling a serious game, equipped with software, a modular physical platform, and two instrumented figurines designed to interact with the software.\n\nIntensive therapy through repetitive movements, supported by the engaging nature of serious games, is expected to improve the manual skills of children with neurological disorders causing motor impairments.\n\nTo test this hypothesis, a cohort of 5 to 10 children aged 4 to 17 years with neurological disorders causing motor impairments will be invited to participate in the protocol. Participants will first undergo a baseline assessment, which will include repeated measurements of their score on the \\*Box and Blocks Test\\* and the active range of motion (AROM) of the wrist in extension and supination. An \\*Assisting Hand Assessment (AHA)\\* test will also be conducted.\n\nFollowing this, a 4-week intervention will be implemented, consisting of three 40-minute sessions per week. During these sessions, the child will play the game and complete the \\*Box and Blocks Test\\* as well as active range of motion assessments.\n\nIn total, approximately 4 hours of gameplay is estimated over the course of the intervention, which will conclude with a repeat of the AHA test.\n\nA follow-up assessment will take place two months after the intervention's end, with a single measurement of the three parameters (\\*Box and Blocks Test\\*, AROM, and AHA).",[102],"Neurologic Disorder","2025-03-11",{"date":105,"type":32},"2025-03-13",{"date":107,"type":32},"2024-11-12",{"date":109,"type":21},"2026-09",{"name":38,"class":39},2,""]