[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Fondazione Don Carlo Gnocchi Onlus\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":674},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,47,0,25,[9,43,81,110,144,175,204,234,260,284,303,330,353,380,401,426,452,485,515,537,562,585,605,626,654],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":16,"eligibilityCriteria":17,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100612382","transcultural-digital-solutions-in-phase-iii-cardiac-rehabilitation-100612382",false,"NCT07252856","Transcultural Digital Solutions in Phase III Cardiac Rehabilitation","CrOss-cultural Model for Postdischarge Assistance and Sustainable Digital Solutions in Phase III Cardiac Rehabilitation: a Randomized Controlled Trial","COMPASS","Inclusion Criteria:\n\n* Age ≥ 18, men and women;\n* patients with atherosclerotic cardiovascular disease (ASCVD) (acute coronary syndrome or chronic coronary syndrome and ischemic heart failure);\n* patients who completed phase II CR and are therefore eligible for CR phase III (maintenance).\n\nExclusion Criteria:\n\n* Unable to sign the informed consent;\n* unable or unwilling to use digital devices due to mental\u002Fcognitive issues or without a support person helping them to access the respective technical devices;\n* pregnant, lactating or women planning pregnancy during the course of the trial.","ALL","18 Years",{"count":21,"type":22},306,"ESTIMATED","INTERVENTIONAL",[25],"NA","Multicenter Prospective Controlled Randomized Trial, open-label, in patients with atherosclerotic cardiovascular disease (ASCVD) (acute coronary syndrome or chronic coronary syndrome and ischemic heart failure) and an approved indication for cardiac rehabilitation (CR). Patients completing phase II CR will be randomized 1:1 to usual Phase-III care (standard care) versus standard care plus the Digitally-Enhanced Extended PrEvention \\& Rehabilitation (DEEPER) package (intervention). Primary outcome is 6-month change in composite Life's Crucial 9 (LC9) (LE8 + PHQ-9).",[28,29],"Heart Failure","Myocardial Infarction","RECRUITING","2026-06-26",{"date":33,"type":34},"2026-06-30","ACTUAL",{"date":36,"type":34},"2026-04-20",{"date":38,"type":22},"2027-07-31",{"name":40,"class":41},"Fondazione Don Carlo Gnocchi Onlus","OTHER",6,{"id":44,"slug":45,"hasResults":12,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":49,"eligibilityCriteria":50,"healthyVolunteers":12,"sex":18,"minAge":51,"maxAge":52,"enrollmentInfo":53,"targetDuration":4,"studyType":23,"phases":55,"briefSummary":56,"conditions":57,"keywords":61,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":80},"100637842","effectiveness-of-a-structured-multidimensional-tele-rehabilitation-intervention-in-cardiac-patients-with-post-intensive-care-syndrome-cardio-pics-100637842","NCT07599306","Effectiveness of a Structured Multidimensional Tele-rehabilitation Intervention in Cardiac Patients With Post-Intensive Care Syndrome (CARDIO-PICS)","Effectiveness of a Structured Multidimensional Tele-rehabilitation Intervention in Cardiac Patients With Post-Intensive Care Syndrome (CARDIO-PICS): Impact on Mortality, Rehospitalization, and Clinical-functional Outcomes.","CARDIO-PICS","Inclusion Criteria:\n\n* Adults aged 30-75 years\n* Previous ICU admission ≥48 hours\n* Presence of Post-Intensive Care Syndrome (PICS), defined as at least one of the following objectively assessed impairments at baseline (T0):\n* Neuromotor impairment, defined as Diagnosis of Critical Illness Myopathy (CIM) or Critical Illness Polyneuropathy (CIP), confirmed by electromyography (EMG)\n* Cognitive impairment, defined as Montreal Cognitive Assessment (MoCA) score \\\u003C 26\n* Psychological impairment, defined as Patient Health Questionnaire-9 (PHQ-9) score ≥ 10\n* Nutritional impairment, defined as the presence of malnutrion according to GLIM criteria, requiring at least one phenotypic criterion (non-volitional weight loss \\>5% within 6 months or \\>10% beyond 6 months; BMI \\\u003C20 kg\u002Fm² if \\\u003C70 years or \\\u003C22 kg\u002Fm² if ≥70 years; reduced muscle mass) and at least one etiologic criterion (reduced food intake or assimilation for \\>1 week, or any acute\u002Fchronic inflammatory burden) and\u002For presence of sarcopenia assessed by calf circumference \\\u003C31 cm and reduced muscle strength measured by handgrip strength\n* Metabolic or bone metabolism disorder, defined as altered bone metabolism markers (Bone Turnover Markers outside reference range)\n\nAbility to provide written informed consent\n\nExclusion Criteria\n\n* Prognostically unfavorable malnutrition defined as: CONUT score ≥5.\n* Delirium present at the time of the enrollment, documented by a positive Confusion Assessment Method (CAM or CAM-ICU)\n* Pre-existing severe cognitive impairment or dementia, defined as:\n\ndocumented diagnosis in the medical record prior to ICU admission\n\n\\- Any clinical condition limiting participation in the rehabilitation program, including: severe orthopedic, neurological, or functional limitations not related to PICS","30 Years","75 Years",{"count":54,"type":22},326,[25],"This two-arm, parallel-group randomized clinical trial investigates the effectiveness of an additional telerehabilitation program compared with standard care in patients with Post-Intensive Care Syndrome (PICS). The post-rehabilitation phase is crucial for consolidating recovery and ensuring continuity of care, with telerehabilitation offering a promising tool to enhance long-term adherence and outcomes.\n\nThe primary objective is to evaluate whether a structured, multidisciplinary remote rehabilitation program can reduce the risk of rehospitalization and mortality while improving clinical, functional, and psychosocial recovery. Approximately 326 patients aged 30-75 years will be enrolled after inpatient rehabilitation and randomly assigned to either a four-month structured telerehabilitation program or standard post-discharge follow-up.\n\nAll participants will undergo assessments at 4 and 12 months to monitor physical, cognitive, psychological, and metabolic recovery, with the ultimate aim of promoting a more complete and sustained rehabilitation after critical illness.",[58,59,60],"Critical Illness","Post Intensive Care Syndrome (PICS)","Cardiopathy",[62,63,64,65,66,67,68,69,70,71],"ICU","PICS","Multimodal rehabilitation","critical illness recovery","Polyneuropathies","Sarcopenia","Nutrition Assessment","Cognitive Dysfunction","Metabolic Diseases","tele-rehabilitation","2026-06-03",{"date":74,"type":34},"2026-06-04",{"date":76,"type":34},"2026-04-13",{"date":78,"type":22},"2028-12-31",{"name":40,"class":41},1,{"id":82,"slug":83,"hasResults":12,"nctId":84,"briefTitle":85,"officialTitle":86,"acronym":87,"eligibilityCriteria":88,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":89,"enrollmentInfo":90,"targetDuration":4,"studyType":23,"phases":92,"briefSummary":93,"conditions":94,"keywords":96,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":101,"lastUpdatePostDateStruct":102,"startDateStruct":104,"completionDateStruct":106,"leadSponsor":108,"locationsCount":109},"100565522","evaluation-of-a-haptic-glove-for-assessing-tactile-perception-in-post-stroke-patients-100565522","NCT06643273","Evaluation of a Haptic Glove for Assessing Tactile Perception in Post-Stroke Patients","A Multicenter Randomized Controlled Trial on the Effects of Upper Limb Robotic Rehabilitation on Sensory and Cognitive Impairments in Subjects With Stroke. The SCORES (Sensory and Cognitive Outcomes of Robotic Exercises in Stroke) Study. Evaluation of a Haptic Glove.","SCORES-glove","Inclusion Criteria:\n\n* a single event, verified by MRI or CT;\n* age between 18 and 85 years;\n* time since stroke within six months;\n* a demographically adjusted total score of the Montreal Cognitive Assessment (MoCA) between 15.5 and 22.23\n\nExclusion Criteria:\n\n* behavioural and cognitive disorders and\u002For reduced compliance that would interfere with active therapy;\n* fixed contraction deformity in the affected limb that would interfere with active therapy (ankylosis, Modified Ashworth Scale = 4);\n* severe deficits in visual acuity.","85 Years",{"count":91,"type":22},126,[25],"The aim of the SCORES Haptic Glove Study is to assess the technical features, safety, and reliability of a sensor-equipped glove designed to evaluate tactile perception. This will help guide further technical and functional improvements to finalize the device. The secondary goal is to validate a new tactile sensitivity index based on data collected using the glove. This will be done in a randomized controlled multicenter study (ClinicalTrials.gov ID NCT06109324) aimed to compare the effectiveness of robotic upper limb rehabilitation to conventional treatment in improving cognitive and sensory deficits, as well as evaluating the impact of these deficits on motor recovery.",[95],"Stroke",[97,98,99,100],"tactile perception","haptic glove","robotics","rehabilitation","2026-04-23",{"date":103,"type":34},"2026-04-24",{"date":105,"type":34},"2024-10-04",{"date":107,"type":22},"2027-04",{"name":40,"class":41},3,{"id":111,"slug":112,"hasResults":12,"nctId":113,"briefTitle":114,"officialTitle":115,"acronym":116,"eligibilityCriteria":117,"healthyVolunteers":12,"sex":18,"minAge":118,"maxAge":4,"enrollmentInfo":119,"targetDuration":4,"studyType":23,"phases":121,"briefSummary":122,"conditions":123,"keywords":127,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":136,"lastUpdatePostDateStruct":137,"startDateStruct":139,"completionDateStruct":141,"leadSponsor":143,"locationsCount":80},"100597879","validation-of-a-digital-intervention-to-rehabilitate-cognitive-resources-100597879","NCT07064226","Validation of a Digital Intervention to Rehabilitate Cognitive Resources","Transcultural and Multidimensional Validation of dIgital Rehabilitation Intervention of COgnitive Resources Domain-Oriented - Work Package 4","MI-RICORDO","Inclusion Criteria:\n\n1. Montreal Cognitive Assessment (MoCA) score \\> 17.79;\n2. Clinical Dementia Rating (CDR) Scale score ≤ 1;\n3. Education level \\> 3 years;\n4. Age ≥ 65 years;\n5. Informed consent to participate, confirmed by signing the consent form;\n6. Availability of a caregiver\u002Fstudy partner able to support the participant;\n7. Stable pharmacological treatment (past 3 months) with acetylcholinesterase inhibitors, if applicable.\n\nExclusion criteria:\n\n1. Presence of dysmetria or marked auditory\u002Fvisual or communication disorders preventing the participation to the trial;\n2. Presence of ongoing rehabilitation program at the time of enrollment or in the 3 months prior to enrollment;","65 Years",{"count":120,"type":22},102,[25],"The goal of this clinical trial is to learn if the use of a digital cognitive rehabilitation system named RICORDO, that is flexible and capable of adapting the rehabilitation pathway according to the needs and capacity of the patients will prove effective for subjects with Subjective Memory Complaint or with Mild Cognitive Impairment or with Mild Dementia.\n\nThe main questions it aims to answer are:\n\nWill the RICORDO rehabilitation treatment, lead to an improvement in the global cognitive level? Will the RICORDO rehabilitation treatment lead to improved activation of participants in managing their own health and healthcare? Researchers will compare the multidomain cognitive rehabilitation strategy of RICORDO digital solution, with a standard paper pencil rehabilitation care (usual care).\n\nParticipants will undergo a comprehensive neuropsychological evaluation immediately before, immediately after and six months after the completion of the rehabilitation program.\n\nBoth interventions, the experimental and the usual care, will last 5 weeks, with 3 weekly sessions of 45 minutes each and can be done autonomously by the patient at home.",[124,125,126],"Mild Cognitive Impairment (MCI)","Subjective Memory Complaint","Dementia Alzheimer Type",[128,129,130,131,132,133,134,135],"telerehabilitation","Alzheimer disease","cognitive decline","cognitive rehabilitation","Digital medicine","Dementia","Mild Cognitive Impairment","neuroimaging","2026-02-12",{"date":138,"type":34},"2026-02-13",{"date":140,"type":34},"2025-10-06",{"date":142,"type":22},"2027-09-30",{"name":40,"class":41},{"id":145,"slug":146,"hasResults":12,"nctId":147,"briefTitle":148,"officialTitle":148,"acronym":149,"eligibilityCriteria":150,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":151,"targetDuration":4,"studyType":153,"phases":4,"briefSummary":154,"conditions":155,"keywords":160,"overallStatus":166,"whyStopped":4,"lastUpdateSubmitDate":167,"lastUpdatePostDateStruct":168,"startDateStruct":170,"completionDateStruct":172,"leadSponsor":174,"locationsCount":109},"100615254","tridimensional-robotic-assessment-of-neglect-in-brain-injured-patients-100615254","NCT07290218","Tridimensional Robotic Assessment of Neglect in Brain Injured Patients","NEGLECTARM3D","Inclusion Criteria:\n\n* Age \\> 18 years;\n* Diagnosis of ischemic or hemorrhagic stroke;\n* Diagnosis of Unilateral Spatial Neglect (assessed by The Hearts Test, Oxford Cognitive Screen, cut-off ± 2);\n* Signed informed consent form.\n\nExclusion Criteria:\n\n* Presence of language deficits (inability to complete the OCS test);\n* Presence of cognitive decline prior to the stroke event;\n* Presence of severe visual and\u002For hearing impairments;\n* Language barriers;\n* Orthopedic, neurological, or psychiatric conditions that could interfere with the study or with the assessment of motor and cognitive function;\n* Uncontrolled epilepsy despite antiepileptic treatment;\n* Behavioral disorders that may interfere with study participation;\n* Presence of medical devices whose functioning could be compromised (e.g., pacemaker, etc.);\n* Object-centered neglect (assessed by the OCS Hearts Test; object asymmetry ± 2).",{"count":152,"type":22},15,"OBSERVATIONAL","The goal of this clinical trial is to assess the usability and feasibility of a robotic and virtual reality-based system called NeglectARm 3D for the three-dimensional assessment of unilateral spatial neglect (USN) in patients with brain injury due to ischemic or hemorrhagic stroke.\n\nThe main questions it aims to answer are:\n\n* Is the NeglectARm 3D system usable and feasible for patients with USN?\n* Do the robotic measurements show preliminary reliability and validity compared with conventional clinical neglect assessments (e.g., BIT, CBS)?\n\nParticipants will:\n\n* Perform two assessment sessions, three weeks apart (T0 and T1);\n* Interact with the NeglectARm 3D system using a robotic end-effector and a VR headset to reach sequentially presented targets in a 3D virtual space;\n* Receive robotic assistance if targets are not reached, allowing the system to record trajectories, spatial positions, and assistance applied;\n* Complete standard clinical neglect tests to enable comparison between robotic and conventional measures.\n\nThis study aims to develop a repeatable, standardized, and objective tool for the assessment of USN in patients with brain injury, potentially improving evaluation of depth perception and spatial attention deficits.",[156,157,95,158,159],"Neglect","Brain Injured Patients","Unilateral Spatial Neglect (USN)","Post-stroke Cognitive Impairment",[156,161,162,163,164,165],"Brain injured patients","Tridimensional robotic assessment","Force-sensitive robot system","Virtual reality (VR) headset","Collaborative robotic system","NOT_YET_RECRUITING","2025-12-04",{"date":169,"type":34},"2025-12-18",{"date":171,"type":22},"2026-01-01",{"date":173,"type":22},"2026-11-30",{"name":40,"class":41},{"id":176,"slug":177,"hasResults":12,"nctId":178,"briefTitle":179,"officialTitle":180,"acronym":181,"eligibilityCriteria":182,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":183,"enrollmentInfo":184,"targetDuration":4,"studyType":23,"phases":186,"briefSummary":187,"conditions":188,"keywords":191,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":167,"lastUpdatePostDateStruct":197,"startDateStruct":199,"completionDateStruct":201,"leadSponsor":203,"locationsCount":80},"100603008","functional-electrical-stimulation-to-treat-critical-neuromyopathy-after-severe-stroke-a-pilot-study-100603008","NCT07130929","Functional Electrical Stimulation to Treat Critical Neuromyopathy After Severe Stroke: a Pilot Study.","Intensive Rehabilitation by Functional Electrical Stimulation for the Treatment of Critical Neuromyopathy in Patients With Severe Stroke Admitted to the Highly Specialized Intensive Rehabilitation Unit: a Pilot Study","RISE","Inclusion Criteria:\n\n* Diagnosis of ischemic or hemorrhagic vascular GCA involving unilateral motor deficit \\\u003C 3 months;\n* Premorbid Modified Rankin Scale \\\u003C2;\n* Age \\>18 years and \\\u003C80 years;\n* Level of Cognitive Functioning \\> 4 for active participation in treatment.\n* MRC total sum score \\\u003C= 48 (range 0 -60) for clinical suspicion of ICU-AW\n* Clinical diagnosis of tetra\u002Fparaparesis of peripheral origin confirmed by neurophysiological examination;\n* Signature of informed consent by the patient or, if incapacitated, by their legal representative.\n\nExclusion Criteria:\n\n* Clinical cardio-respiratory or internal instability such as to prevent treatment;\n* History of previous comorbidity for ICU-AW;\n* Previous known chronic neuropathy;\n* Severe coagulopathy;\n* Skin integrity problems at the interface surfaces with the electrostimulator;\n* Epilepsy not controlled by medication;\n* Presence of implanted electronic devices;\n* Pregnancy or breastfeeding;\n* Severe spasticity with a score of \\>3 on the modified Ashworth scale;\n* Treatment with botulinum toxin;\n* Recent malignant neoplasm;\n* Conditions that put you at risk for neuropathies, e.g., history of diabetes mellitus, renal failure, hepatic failure, vitamin deficiencies, chronic alcoholism, vasculitis, previous use of neurotoxic drugs.","80 Years",{"count":185,"type":22},24,[25],"This study aims to evaluate the effectiveness of physiotherapy treatment combined with functional electrical stimulation (FES) in a small group of patients with severe acquired brain injury (SABI) of vascular origin and with a clinical and instrumental diagnosis of \"Intensive Care Unit-Acquired Weakness\" (ICU-AW). Functional electrical stimulation is a technology that uses electrical impulses, generated by an external device, to reactivate the neuromuscular system through electrodes applied to the skin. In functional electrical stimulation, this process is integrated into physiotherapy sessions, with the active involvement of the patient, through the performance of exercises with the assistance and supervision of the physiotherapist. The rationale behind this is to stimulate neuroplasticity processes by facilitating movement through the application of electrical stimuli and the active participation of the patient in performing a motor task, in an attempt to promote improvement in an impaired function.\n\nIn particular, the objectives that will be pursued are: improvement of lower limb neuromyopathy assessed clinically using the Medical Research Council (MRC) scale, the Fugl-Meyer scale for lower limbs, the Short Physical Performance Battery (SPPB) scale, the assessment of active and passive Range Of Motion (ROM) of the main joints of the lower limb (hip, knee, ankle) and measured instrumentally by neurophysiological examination and ultrasound examination.\n\nAfter randomization, patients in the control arm will be treated with physiotherapy and speech therapy sessions as per the conventional protocol, and an additional 15 physiotherapy sessions lasting 60 minutes over a period of 5 weeks. Alternatively, patients in the experimental group will receive, in addition to conventional rehabilitation treatment, a treatment consisting of 15 physiotherapy sessions combined with FES lasting 60 minutes over a period of 5 weeks.\n\nAt the end of the treatment period, baseline characteristics and clinical and instrumental outcome variables will be compared between the two groups using the chi-square test for dichotomous and categorical variables and the t-test for independent samples or the Mann-Whitney U test for continuous variables, depending on whether or not they are normally distributed. In all analyses, a p-value \\\u003C0.05 will be considered significant.",[189,190],"Intensive Care Unit (ICU) Acquired Weakness (ICU - AW)","Acquired Brain Injury (Including Stroke)",[192,193,194,195,196],"stroke","Intensive Care Unit (ICU) acquired weakness (ICU - AW)","Functional Electrical Stimulation","FES","Rehabilitation",{"date":198,"type":34},"2025-12-11",{"date":200,"type":34},"2025-09-23",{"date":202,"type":22},"2027-03-23",{"name":40,"class":41},{"id":205,"slug":206,"hasResults":12,"nctId":207,"briefTitle":208,"officialTitle":208,"acronym":209,"eligibilityCriteria":210,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":89,"enrollmentInfo":211,"targetDuration":4,"studyType":23,"phases":213,"briefSummary":214,"conditions":215,"keywords":219,"overallStatus":166,"whyStopped":4,"lastUpdateSubmitDate":225,"lastUpdatePostDateStruct":226,"startDateStruct":228,"completionDateStruct":230,"leadSponsor":232,"locationsCount":233},"100608266","clinical-validation-of-an-ai-based-decision-support-system-for-robotic-upper-limb-rehabilitation-in-patients-with-stroke-a-co-aider-study-100608266","NCT07199322","Clinical validatiOn of an AI-based DEcision Support System for Robotic Upper Limb Rehabilitation in Patients With Stroke. A CO-AIDER Study.","COAIDER","Inclusion Criteria:\n\n* Diagnosis of ischemic or hemorrhagic stroke confirmed by Computed Tomography (CT) or Magnetic Resonance Imaging (MRI);\n* Age between 18 and 85 years;\n* Time since stroke less than six months;\n* Mild to severe upper limb impairment (Fugl-Meyer Assessment for Upper Extremity (FMA-UE) ≤ 58).\n\nExclusion Criteria:\n\n* Behavioral or cognitive disorders and\u002For reduced compliance;\n* Severe spasticity or hypertonia in the affected limb (Modified Ashworth Scale (MAS) \\> 3);\n* Severe visual impairments;\n* Concurrent participation in another clinical trial for upper limb rehabilitation following stroke;\n* Refusal to provide written informed consent.",{"count":212,"type":22},100,[25],"The goal of this clinical trial is to validate an artificial intelligence-based decision support system (AI-DSS) for robotic rehabilitation in participants with stroke.\n\nThe study aims to answer the following questions:\n\n* Can the AI-DSS support therapists in setting therapy parameters and adapting personalized robotic rehabilitation programs effectively?\n* Can AI-supported robotic rehabilitation improve upper limb function, activities of daily living (ADL), cognitive function, and quality of life compared with standard therapist-guided robotic rehabilitation?\n\nResearchers will compare two groups:\n\n* Robotic rehabilitation supported by the AI-DSS (CO-AIDER);\n* Robotic rehabilitation with parameters set by therapists (control group).\n\nParticipants will:\n\n* Receive robotic rehabilitation for the upper limb, either guided by the AI-DSS or by therapists;\n* Be monitored throughout the program, with therapy parameters adjusted according to their progress;\n* Complete assessments to evaluate changes in upper limb function, activities of daily living, cognitive function, and quality of life.\n\nThe study will also evaluate the usability and acceptability of the AI-supported robotic system as perceived by participants and clinical staff, and will include a cost-effectiveness analysis of the two interventions.",[95,216,217,218],"Stroke Ischemic","Stroke Hemorrhagic","Upper Limb Rehabilitation",[95,220,221,222,223,224,100],"Upper limb rehabilitation","Artificial Intelligence","Robot-assisted therapy","AI-supported robotic system","AI-based decision support system","2025-09-26",{"date":227,"type":34},"2025-09-30",{"date":229,"type":22},"2025-09",{"date":231,"type":22},"2026-12",{"name":40,"class":41},10,{"id":235,"slug":4,"hasResults":12,"nctId":236,"briefTitle":237,"officialTitle":238,"acronym":239,"eligibilityCriteria":240,"healthyVolunteers":241,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":242,"targetDuration":4,"studyType":153,"phases":4,"briefSummary":244,"conditions":245,"keywords":247,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":251,"lastUpdatePostDateStruct":252,"startDateStruct":254,"completionDateStruct":256,"leadSponsor":258,"locationsCount":259},"100540913","NCT06323031","Spontaneous Eye Blinking in Disorders of Consciousness","Spontaneous Eye Blinking as a Diagnostic and Prognostic Marker in Patients With Disorders of Consciousness After Severe Acquired Brain Injury","Blink-DoC","Inclusion Criteria:\n\n* clinical diagnosis of DoC (UWS, MCS minus, MCS plus) following repeated clinical evaluation (at least four CRS-R in a week)\n* age ≥ 18 years\n* time post-onset ≤6 months\n* Previous sABI of any etiology (traumatic, vascular, anoxic, mixed, etc.)\n* Negative anamnesis for neurological or psychiatric disorders.\n\nExclusion Criteria:\n\n* unstable clinical conditions (e.g. respiratory failure, fever, status epilepticus, etc.);\n* ophthalmic diseases, or clinically detected peripheral damage in eyelid motility (e.g. orbital fracture);\n* intake of sedative drugs in the preceding 24 hours;\n* additional brain event following admission (e.g., stroke).",true,{"count":243,"type":22},70,"Differential diagnosis between Unresponsive Wakefulness Syndrome (UWS) and Minimally Conscious State (MCS) is complicated due to severe cognitive and\u002For sensorimotor deficits in these patients. In this study the investigators aimed at exploring the diagnostic and prognostic validity of spontaneous eye blinking parameters (rate, amplitude, duration, variability) in a sample of patients with Disorders of Consciousness (DoC).\n\nThis is a multi-center prospective observational study conducted in patients with Severe Acquired Brain Injury (sABI) and DoC admitted to 8 European participating centers, with clinical data collection not deviating from routine practice. The study is non-commercial and will have a maximum total duration of 24 months.",[246],"Disorders of Consciousness",[246,248,249,250,100],"blinking","diagnosis","prognosis","2025-09-24",{"date":253,"type":34},"2025-09-29",{"date":255,"type":34},"2025-03-31",{"date":257,"type":22},"2026-06",{"name":40,"class":41},8,{"id":261,"slug":262,"hasResults":12,"nctId":263,"briefTitle":264,"officialTitle":265,"acronym":266,"eligibilityCriteria":267,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":268,"targetDuration":4,"studyType":23,"phases":270,"briefSummary":271,"conditions":272,"keywords":274,"overallStatus":166,"whyStopped":4,"lastUpdateSubmitDate":276,"lastUpdatePostDateStruct":277,"startDateStruct":279,"completionDateStruct":281,"leadSponsor":283,"locationsCount":80},"100605233","telerehabilitation-in-central-and-peripheral-neurological-sequelae-from-chemotherapy-100605233","NCT07159854","Telerehabilitation in Central and Peripheral Neurological Sequelae From Chemotherapy","TeleRehabilitation: an Innovative User-centered STrategic Approach for the treatMent of Central and Peripheral Neurological sEquelae From Chemotherapy - TRUST_ME","TRUST_ME","Inclusion Criteria:\n\n* Adult subjects (\\>18 years old) with central and\u002For peripheral neurotoxic sequelae following a history of cancer treated with chemotherapeutic agents (Cisplatin and Taxanes), in accordance with the criteria of the International Cognitive Cancer Task Force (Wefel et al., 2011. 10.1016\u002FS1470-2045(10)70294-1)\n* agreement to participate with the signature of the informed consent form;\n\nExclusion Criteria:\n\n* Ongoing chemotherapy treatment;\n* Pre-existing neurological or psychiatric comorbidities (e.g., epilepsy, post-stroke disability, neurodegenerative diseases, genetically based polyneuropathy);\n* Severe visual or hearing impairments that could interfere with the use of technology;\n* Severe cognitive impairment (Mini-Mental State Examination score \\\u003C18);\n* Severe postural disability associated with a high risk of falling at home, as documented in the clinical evaluation;\n* Contraindications to undergoing MRI examination;\n* Ongoing rehabilitation treatment.",{"count":269,"type":22},60,[25],"The goal of this clinical trial is to validate the use of innovative tele-rehabilitation (TR) models in terms of efficiency and effectiveness in a pilot cohort of subjects with central and peripheral chemotherapy-induced neurotoxicity. Participants will be randomized (with an allocation ratio of 1:1) into the experimental group (TRUST\\_ME - 15 sessions of motor and cognitive activities delivered at home through a TR approach using the Maia platform) and Treatment as Usual (15 sessions of multimedia content of educational\u002Frehabilitation activities delivered via telemedicine platfom). It expected that the TR system to be considered acceptable in terms of efficiency (usability and acceptability of the technologies) and clinically effective, with positive impacts on both quality of life and central and peripheral functioning in these patients.",[273],"Chemotherapy-induced Neurotoxicity",[275,100,128],"Chemotherapy-induced neurotoxicity","2025-08-29",{"date":278,"type":34},"2025-09-08",{"date":280,"type":22},"2025-09-01",{"date":282,"type":22},"2026-08-31",{"name":40,"class":41},{"id":285,"slug":286,"hasResults":12,"nctId":287,"briefTitle":288,"officialTitle":288,"acronym":4,"eligibilityCriteria":289,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":290,"targetDuration":4,"studyType":153,"phases":4,"briefSummary":292,"conditions":293,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":295,"lastUpdatePostDateStruct":296,"startDateStruct":298,"completionDateStruct":300,"leadSponsor":302,"locationsCount":80},"100598031","impact-assessment-of-salsa-sensing-and-automation-for-freedom-security-autonomy-technological-solutions-100598031","NCT07066202","Impact Assessment of SALSA (Sensing and Automation for Freedom, Security, Autonomy) Technological Solutions","Inclusion Criteria:\n\n* older than 18 years of age;\n* mental, social and\u002For motor disability;\n* signature of consent for participation.\n\nExclusion Criteria:\n\n* under 18 years of age;\n* non-signature of consent to participation.",{"count":291,"type":22},55,"This study evaluates the impact of assistive technologies designed to improve the independence and safety of adults with disabilities living in shared residential environments. The project is called SALSA, which stands for \"Sensorisation, Automation for Freedom, Security and Autonomy.\" It is being conducted in Milan, Italy, by a collaboration between Cascina Biblioteca Società Cooperativa Sociale, Fondazione Don Carlo Gnocchi ONLUS, and Informatici Senza Frontiere APS.\n\nThe goal of the study is to determine how well specific technologies-such as smart lighting systems and wearable monitoring devices-support residents' autonomy and daily functioning, while also reducing the workload for professional caregivers. These technologies are installed in apartments where people with mental, social, and\u002For physical disabilities live together with some support.\n\nA total of 55 adults over the age of 18, all residents of Cascina Biblioteca's shared flats, will be enrolled. Technologies will be set up prior to the beginning of the trial. Data will be collected in three phases: before using the technologies (T0), after 30 days (T1), and after 60 days (T2). The evaluation includes personalized goals, physical environment metrics (like temperature, air quality, door use, and night movements), and ease of use of the systems by staff.\n\nThe study uses Goal Attainment Scaling (GAS) to track whether residents achieve their individual or group goals, and the System Usability Scale (SUS) to assess how user-friendly the technologies are from the caregivers' perspective. All data will be collected through structured webforms to reduce the chance of missing information and increase consistency. The study team will use both descriptive and inferential statistical methods to assess results over time.\n\nA total of 55 adults over the age of 18, all residents of Cascina Biblioteca's shared flats, will be enrolled. Technologies will be set up prior to the beginning of the trial. Data will be collected in three phases: before using the technologies (T0), after 30 days (T1), and after 60 days (T2). The evaluation includes personalized goals, physical environment metrics (like temperature, air quality, door use, and night movements), and ease of use of the systems by staff.\n\nThe study uses Goal Attainment Scaling (GAS) to track whether residents achieve their individual or group goals, and the System Usability Scale (SUS) to assess how user-friendly the technologies are from the caregivers' perspective. All data will be collected through structured webforms to reduce the chance of missing information and increase consistency. The study team will use both descriptive and inferential statistical methods to assess results over time.\n\nThis research aims to provide practical insights into how technology can support adults with disabilities in more independent, safer living situations. It may also inform broader applications of these systems in similar care contexts. The protocol was approved by an Ethics Committee (CET 130\u002F24; FDG 28\\_17\u002F12\u002F2024) and is in the data collection phase as of early 2025.",[294],"Generalized Mental, Social and\u002For Motor Disability","2025-08-25",{"date":297,"type":34},"2025-08-26",{"date":299,"type":34},"2025-03-11",{"date":301,"type":22},"2025-10-31",{"name":40,"class":41},{"id":304,"slug":305,"hasResults":12,"nctId":306,"briefTitle":307,"officialTitle":307,"acronym":308,"eligibilityCriteria":309,"healthyVolunteers":12,"sex":18,"minAge":4,"maxAge":4,"enrollmentInfo":310,"targetDuration":312,"studyType":153,"phases":4,"briefSummary":313,"conditions":314,"keywords":319,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":295,"lastUpdatePostDateStruct":325,"startDateStruct":326,"completionDateStruct":328,"leadSponsor":329,"locationsCount":80},"100558107","outcomes-of-ict-assistive-technology-in-rehabilitation-pathways-100558107","NCT06546813","Outcomes of ICT Assistive Technology in RehabiliTAtIoN Pathways","ATTAIN","consecutive enrollment of subjects falling within\n\nInclusion Criteria:\n\n* patients in need of prosthetic interventions for Augmentative Alternative Communication, computer accessibility, and environmental control\n* patients who agree to participate in the study\n\nExclusion Criteria:\n\n* none",{"count":311,"type":22},50,"6 Months","The study aims to improve the quality of prosthetic intervention and verify the adequacy of assistive devices, and measurement outcomes. Fifty patients in need of prosthetic interventions for Augmentative Alternative Communication, computer accessibility, and environmental control will be recruited within the DAT Unit of the Fondazione Don Carlo Gnocchi \"IRCCS S.Maria Nascente\" in Milan. At baseline (T0) a physician and a psychologist will perform a clinical evaluation and the AT outcome assessment. The participants will be contacted for the follow-up phase (T1) 3 to 6 months after having received the assistive solution. At T1 clinicians will readminister the AT outcome assessment. In order to make the assessment accessible to all participants, these tests and questionnaires will be administered on Windows PCs, using Grid3 software, or on a specifically created accessible web page.",[315,316,317,318],"Communication Aids for Disabled","Communication Disorders","Motor Disorders","Cognitive Disorder",[320,321,322,323,324],"ICT AT","AAC AT","AAL AT","Assistive Technology","Outcome Assessment",{"date":297,"type":34},{"date":327,"type":34},"2023-06-01",{"date":301,"type":22},{"name":40,"class":41},{"id":331,"slug":332,"hasResults":12,"nctId":333,"briefTitle":334,"officialTitle":334,"acronym":335,"eligibilityCriteria":336,"healthyVolunteers":241,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":337,"targetDuration":4,"studyType":23,"phases":339,"briefSummary":340,"conditions":341,"keywords":343,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":295,"lastUpdatePostDateStruct":346,"startDateStruct":348,"completionDateStruct":350,"leadSponsor":352,"locationsCount":80},"100502600","exercise-and-heart-transplant-100502600","NCT05824364","Exercise aNd hEArt Transplant","ENEA","Inclusion Criteria:\n\n* All the patients admitted in the on-site CR after HTx\n\nExclusion Criteria:\n\n* unable to sign informed consent",{"count":338,"type":22},40,[25],"Registry-based randomized clinical trial (RRCT) to assess the safety and efficacy of two different schemes of exercise training in patients who have recently undergone heart transplantation",[342],"Heart Transplant",[344,128,345],"cardiac rehabilitation","rehabilomics",{"date":347,"type":34},"2025-09-02",{"date":349,"type":34},"2023-05-20",{"date":351,"type":22},"2025-11-28",{"name":40,"class":41},{"id":354,"slug":355,"hasResults":12,"nctId":356,"briefTitle":357,"officialTitle":358,"acronym":4,"eligibilityCriteria":359,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":360,"targetDuration":4,"studyType":153,"phases":4,"briefSummary":362,"conditions":363,"keywords":364,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":372,"lastUpdatePostDateStruct":373,"startDateStruct":375,"completionDateStruct":377,"leadSponsor":379,"locationsCount":80},"100423260","sarcopenia-and-nutritional-status-in-a-rehabilitation-setting-100423260","NCT04791540","Sarcopenia and Nutritional Status in a Rehabilitation Setting","Observational Pilot Study in Patients Who Underwent Tracheostomy: Sarcopenia Assessment by Handgrip Strenght and BIA. Association to Malnutrion Risk, Nutritional Status, Gut Microbioma and Decannulation Time.","Inclusion Criteria:\n\n* Signed informed consent from patients or legal guardians for patients unfit to plead\n* Presence of tracheostomy at admission\n\nExclusion Criteria:\n\n* Refusal\n* Pregnancy\n* Pace maker\u002Fimplantable cardioverter\n* No legal guardians for patients unfit to plead",{"count":361,"type":22},30,"In this pilot observational study the primary outcome is to assess, in a Respiratory Rehabilitation Unit, if there is an association between sarcopenia, assessed by handgrip strenght and BIA, and a delayed decannulation time in patients who underwent tracheostomy.\n\nSecondary outcomes are to assess if there is an association between an increased malnutrition risk (assessed by MUST), a poor nutritional status (assessed by GLIM criteria) and a delayed decannulation time and the gut microbiota composition.",[67],[365,366,367,368,369,370,371],"handgrip strenght","bioelectrical impedance analysis (BIA)","respiratory rehabilitation","tracheostomy decannulation","gut microbiota","GLIM criteria","MUST","2025-08-21",{"date":374,"type":34},"2025-08-28",{"date":376,"type":34},"2021-06-09",{"date":378,"type":22},"2025-12-31",{"name":40,"class":41},{"id":381,"slug":382,"hasResults":12,"nctId":383,"briefTitle":384,"officialTitle":385,"acronym":386,"eligibilityCriteria":387,"healthyVolunteers":241,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":388,"targetDuration":4,"studyType":23,"phases":389,"briefSummary":390,"conditions":391,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":393,"lastUpdatePostDateStruct":394,"startDateStruct":396,"completionDateStruct":398,"leadSponsor":400,"locationsCount":80},"100568886","a-heart-rate-variability-hrv-biofeedback-training-in-functional-gastrointestinal-disorders-fgid-100568886","NCT06687057","A Heart Rate Variability (HRV) Biofeedback Training in Functional Gastrointestinal Disorders (FGID)","A Heart Rate Variability (HRV) Biofeedback Training to Reduce Symptomatology Associated With Functional Gastrointestinal Disorders (FGID) in College Students.","BF_FDGI","Inclusion Criteria:\n\n* presence of clinically significant anxiety symptoms (DASS-21 \\> 4)\n* presence of symptoms related to Functional Gastrointestinal Disorders (in English, known as Functional Gastrointestinal Disorders (FGIDs)) (IBS-SSS \\> 75);\n* obtaining informed consent to participate in the study;\n* Absence of organic gastrointestinal diseases: thus, they will be excluded if with a current or previous diagnosis of intestinal disease (e.g., ulcerative colitis);\n* absence of clinical conditions including neurological disorders (previous head trauma, degenerative neurological disorders, stroke, etc.) and cardiovascular disorders (hypertension, cardiac arrhythmias, etc.).\n\nExclusion Criteria:\n\n* absence of clinically significant anxiety symptoms (DASS-21\\\u003C 4);\n* absence of symptoms related to Functional Gastrointestinal Disorders (in English, known as Functional Gastrointestinal Disorders (FGIDs)) (IBS-SSS \\\u003C 75);\n* lack of obtaining Informed Consent to participate in the study;\n* presence of organic gastrointestinal diseases: therefore, they will be excluded if with a current or previous diagnosis of intestinal disease (e.g., ulcerative colitis).\n* presence of clinical conditions including neurological disorders (previous head trauma, degenerative neurological disorders, stroke, etc.) and cardiovascular disorders (hypertension, cardiac arrhythmias, etc.).",{"count":338,"type":22},[25],"Functional Gastrointestinal Disorders (FGIDs) are conditions characterized by chronic gastrointestinal symptoms without evidence of pathology. These disorders are believed to result from alterations in gut-brain communication. The most common subtypes are Irritable Bowel Syndrome (IBS) and Functional Dyspepsia (FD), often accompanied by chronic pain, anxiety, and depression. The role of stress in the manifestation of FGIDs is notable, with stress-related distress affecting the nerve pathways that connect gut and brain. Recent interest has focused on the use of Heart Rate Biofeedback (HRV). High levels of stress are associated with reduced HRV, which is common in patients with FGID. HRV biofeedback has been shown to be effective in improving parasympathetic tone and reducing sympathetic tone. The present study aims to evaluate the effectiveness of this approach in reducing stress and symptoms associated with FGIDs in college students.\n\nThe project involves online screening to recruit participants, who will then be randomized to receive either the true HRV biofeedback treatment or a placebo condition. Pre- and post-treatment assessments include psychological questionnaires, physiological recordings, and a three-month follow-up. The treatment is expected to improve HRV, thereby reducing anxiety and gastrointestinal symptoms.",[392],"Functional Gastrointestinal Disorders (FGIDs)","2025-08-19",{"date":395,"type":34},"2025-08-24",{"date":397,"type":34},"2024-12-01",{"date":399,"type":22},"2026-01-31",{"name":40,"class":41},{"id":402,"slug":403,"hasResults":12,"nctId":404,"briefTitle":405,"officialTitle":406,"acronym":407,"eligibilityCriteria":408,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":409,"targetDuration":411,"studyType":153,"phases":4,"briefSummary":412,"conditions":413,"keywords":415,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":393,"lastUpdatePostDateStruct":420,"startDateStruct":421,"completionDateStruct":423,"leadSponsor":425,"locationsCount":80},"100567151","brain-fog-in-sleep-apnea-100567151","NCT06664450","Brain Fog in Sleep Apnea","Exploring Brain Fog Symptoms in Patients With Obstructive Sleep Apnea and CPAP Therapy Impact: A Pilot Study","BF -OSA","Inclusion Criteria:\n\n* Patients with severe OSA treated with CPAP for at least 3 months.\n* Patients with severe OSA in new access and therefore not yet subjected to CPAP treatment.\n* Patients with severe OSA who are able to understand the Italian language.\n\nExclusion Criteria:\n\n* Patients who do not have a certified diagnosis of severe OSA.\n* Patients with mild or moderate OSA.\n* Patients with OSA who are unable to understand the Italian language.\n* Patients with OSA who have neurological and\u002For oncological comorbidities, as verified by medical records.\n* Patients with documented cognitive deficits, as verified by medical records.\n* Patients with certified diagnoses of psychiatric disorders and\u002For substance use disorders (SUD), as verified by medical records.",{"count":410,"type":22},80,"1 Day","Objective: This observational, cross-sectional pilot study aims to assess \"Brain Fog\" (cognitive symptoms impacting memory, attention, and concentration) in severe Obstructive Sleep Apnea (OSA) patients. It compares two groups: those on CPAP treatment for at least 3 months and those not yet treated.\n\nProcedures: Severe OSA patients (AHI \\> 30) will complete a 30-minute questionnaire at the Sleep Center Clinic, covering sociodemographic information, OSA diagnosis, and treatment details. Assessment scales will measure daytime sleepiness, sleep quality, and psychophysical fatigue.\n\nParticipants: 80 Sleep Center outpatients, evenly divided by age and gender:\n\n40 with severe OSA on CPAP for at least 3 months. 40 with severe OSA not yet on CPAP. Duration: Approximately 12 months.",[414],"Obstructive Sleep Apnea",[416,417,418,419],"Obstructive Sleep Apnea (OSA)","Brain Fog","Cognitive Impairment","CPAP Therapy",{"date":395,"type":34},{"date":422,"type":34},"2025-02-03",{"date":424,"type":22},"2026-04-07",{"name":40,"class":41},{"id":427,"slug":428,"hasResults":12,"nctId":429,"briefTitle":430,"officialTitle":431,"acronym":432,"eligibilityCriteria":433,"healthyVolunteers":241,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":434,"targetDuration":4,"studyType":23,"phases":435,"briefSummary":436,"conditions":437,"keywords":439,"overallStatus":166,"whyStopped":4,"lastUpdateSubmitDate":443,"lastUpdatePostDateStruct":444,"startDateStruct":446,"completionDateStruct":448,"leadSponsor":450,"locationsCount":451},"100600498","improving-hand-movement-and-coordination-in-people-with-multiple-sclerosis-using-transcranial-magnetic-stimulation-tms-and-muscle-electrostimulation-fes-to-support-manual-dexterity-and-daily-function-100600498","NCT07098273","Improving Hand Movement and Coordination in People With Multiple Sclerosis Using Transcranial Magnetic Stimulation (TMS) and Muscle Electrostimulation (FES) To Support Manual Dexterity and Daily Function","Restoring Manual Dexterity in Multiple Sclerosis: A Feasibility Study Combining Muscle Electrostimulation and Transcranial Magnetic Stimulation To Enhance Neuroplasticity","MANTRAStim","Inclusion Criteria:\n\n* age \\>18;\n* diagnosis of MS (according to McDonald criteria);\n* stable disease course without a worsening greater than 1 point on the Expanded Disability Status Scale (EDSS) in the past 4 months;\n* right-handed;\n* score on the Box and Block test lower than the normative value adjusted for sex and age +2 standard deviations;\n* score on the cerebellar functional system of the EDSS scale \\\u003C2;\n* ability to provide written informed consent.\n\nExclusion Criteria:\n\n* score on the Mini-Mental State Examination \\\u003C24;\n* Beck Depression Inventory-II \\>19;\n* other neurological or orthopedic conditions that would interfere with upper limb exercises;\n* contraindications to the application of TMS: history of epilepsy or non-febrile seizures; presence of metallic or electronic implants in the cranial or cervical region; presence of pacemakers or implantable defibrillators; severe uncontrolled psychiatric disorders (e.g., psychosis, mania); current or suspected pregnancy;\n* contraindications to the application of FES: skin integrity issues at the site of electrode placement; implanted electronic devices.",{"count":311,"type":22},[25],"The goal of this interventional study is to test whether combining transcranial magnetic stimulation (TMS) with functional electrical stimulation (FES) can improve hand and upper limb function in adults with Multiple Sclerosis (MS).\n\nThe clinical trial aims to determine the following points:\n\n1. Whether TMS combined with FES produces greater effects compared to FES alone.\n2. Changes in brain and muscle activity related to hand function after treatment.\n3. Specific clinical or neurophysiological factors that predict who will benefit most from the intervention. Researchers will compare the TMS-FES group (receiving brain magnetic stimulation and muscle electrostimulation) with the FES group (receiving only muscle electrostimulation) to assess whether TMS provides additional benefits in improving upper limb function\n\nParticipants will:\n\n* Be assigned to a group (TMS-FES group or FES group)\n* Attend 15 sessions (45 minutes each, 3 times per week for 5 weeks) of task-based hand and arm exercises, during which FES, or TMS and FES, will be administered to the participant.\n* Undergo assessments before, after, and 3 months after training to measure hand function, brain and muscle responses, fatigue, and daily activity performance.",[438],"Multiple Sclerosis",[438,440,441,194,442],"Hand Dexterity","Technology-based Rehabilitation","Transcranial Magnetic Stimulation","2025-08-06",{"date":445,"type":34},"2025-08-12",{"date":447,"type":22},"2025-10",{"date":449,"type":22},"2027-05",{"name":40,"class":41},2,{"id":453,"slug":454,"hasResults":12,"nctId":455,"briefTitle":456,"officialTitle":457,"acronym":458,"eligibilityCriteria":459,"healthyVolunteers":12,"sex":18,"minAge":460,"maxAge":4,"enrollmentInfo":461,"targetDuration":463,"studyType":153,"phases":4,"briefSummary":464,"conditions":465,"keywords":471,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":476,"lastUpdatePostDateStruct":477,"startDateStruct":479,"completionDateStruct":481,"leadSponsor":483,"locationsCount":484},"100582886","saliva-and-extracellular-vesicles-for-neurodegenerative-diseases-100582886","NCT06869135","Saliva and Extracellular Vesicles for Neurodegenerative Diseases","Novel Method for Diagnosis of Neurodegenerative Diseases Based on Saliva Biochemical Profiling","MINERVA","Inclusion Criteria:\n\n* AD: standard criteria for dementia due to AD with AD neurochemical demonstration.\n* PD: MDS Criteria; modified Hoehn\\&Yahr stages; stable pharmacological treatment (last 4 weeks).\n* AtP: current consensus diagnostic criteria for progressive supranuclear palsy; corticobasal degeneration and multiple system atrophy.\n* prodromic PD: according to diagnostic criteria by Berg;\n* MCI: according to diagnostic criteria by Dubois and Albert.\n\nExclusion Criteria:\n\n* For all the experimental groups considered, subjects with concomitant chronic and \u002F or inflammatory diseases of the oral cavity, other systemic diseases, oncological or infectious diseases will be excluded.\n* Patients not able to provide written informed consent autonomously will be excluded.\n* For PD patients: Vascular, familiar and drug- induced parkinsonism, other known or suspected causes (metabolic, brain tumor etc) or any suggestive features of AtP; dementia with MoCA Test Correct Score\\\u003C15","45 Years",{"count":462,"type":22},242,"12 Months","Early diagnosis of Neurodegenerative diseases (NDDs) and accurate patient profiling are key goals needed to tailor prompt personalized therapeutic strategies that can significantly impact disease progression and patients' quality of life. The project will validate a novel, cost-effective and quick biophotonic-based method for early and differential diagnosis of NDDs (Parkinson's disease, atypical parkinsonisms, Alzheimer's disease) and for routine clinical monitoring of NDD progression (longitudinal study). Raman spectroscopy (RS) will be applied to biochemically profile saliva and salivaderived Extracellular Vesicles (sEVs) and to identify a spectroscopic biomarker for NDDs. Optimized protocols for RS will be used to concomitantly evaluate saliva and sEVs from people with NDDs and to detect salivary changes in the biochemical profile, with special focus on EV-associated components. The accuracy of the method in discriminating NDDs at different disease stages and during disease progression will be verified. A nanotechnology-based biomolecular characterization of saliva and sEV will clarify the involvement of specific pathological molecules in NDDs progression.",[466,467,468,469,124,470],"Neurodegenerative Diseases","Parkinson Disease","Alzheimer Disease","Parkinsonism","Prodromal Parkinson's Disease",[472,473,474,475],"Saliva","Raman Spectroscopy","Extracellular Vesicles","Diagnosis","2025-08-04",{"date":478,"type":34},"2025-08-07",{"date":480,"type":34},"2025-01-24",{"date":482,"type":22},"2027-12-15",{"name":40,"class":41},5,{"id":486,"slug":487,"hasResults":12,"nctId":488,"briefTitle":489,"officialTitle":490,"acronym":491,"eligibilityCriteria":492,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":493,"targetDuration":495,"studyType":153,"phases":4,"briefSummary":496,"conditions":497,"keywords":503,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":507,"lastUpdatePostDateStruct":508,"startDateStruct":510,"completionDateStruct":512,"leadSponsor":514,"locationsCount":80},"100600226","the-italian-alliance-for-cardiovascular-rehabilitation-and-prevention-itacare-p-registry-an-observational-study-on-cardiac-rehabilitation-in-patients-with-coronary-disease-or-heart-failure-100600226","NCT07094737","The Italian Alliance for Cardiovascular Rehabilitation and Prevention (ITACARE-P) Registry: An Observational Study on Cardiac Rehabilitation in Patients With Coronary Disease or Heart Failure","The ITACARE-P CardioRehab Registry","CardioRehab","Inclusion Criteria:\n\n* Patients with coronary artery disease and\u002For heart failure who meet the current regulatory requirements for appropriateness of referral to cardiac rehabilitation are eligible for enrollment. These patients may be included regardless of whether they are referred to inpatient or outpatient cardiac rehabilitation programs, depending on the clinical setting and care pathway.\n\nExclusion Criteria:\n\n* Explicit refusal to participate in the study by the patient;\n* Planned hospital readmission within six months after completion of the cardiac rehabilitation program.",{"count":494,"type":22},1600,"12 Years","ITACARE-P CardioRehab Registry is a nationwide observational study conducted in Italy and coordinated by the Fondazione Don Carlo Gnocchi in Milan. It involves multiple hospitals and rehabilitation centers across the country and aims to better understand how cardiac rehabilitation (CR) is delivered to patients recovering from heart conditions (coronary deseases and\u002For heart failure). CR is a structured program that includes exercise, lifestyle education, and psychological support, and is known to improve recovery, reduce future cardiac events, lower hospital readmissions, and enhance quality of life. Despite strong recommendations from international guidelines, not all eligible patients are referred to CR, and its delivery varies. This study collects real-world data to describe how CR programs are implemented, evaluate patient outcomes, identify subgroups needing tailored care, and support improvements in cardiac care services in Italy. Adults who recently experienced a qualifying heart condition are enrolled and followed during their standard rehabilitation, without any changes to treatment. Data on medical history, risk factors, quality of life, functional improvements, and medication use are collected, with follow-up at 6 and 12 months. Participation involves no added risks, and personal health data is securely managed according to EU GDPR regulations using the REDCap system. The study aims to enhance the quality, consistency, and equity of cardiac rehabilitation across the country.",[498,28,499,500,196,501,502],"Cardiac Rehab","Coronary Disease","Heart Conditions","Cardiac Rehabilitation","Telerehabilitation",[498,28,504,505,196,506,502],"Coronary disease","Heart conditions","Cardiac rehabilitation","2025-07-23",{"date":509,"type":34},"2025-07-30",{"date":511,"type":34},"2025-05-01",{"date":513,"type":22},"2027-12-31",{"name":40,"class":41},{"id":516,"slug":517,"hasResults":12,"nctId":518,"briefTitle":519,"officialTitle":520,"acronym":521,"eligibilityCriteria":522,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":523,"targetDuration":4,"studyType":23,"phases":524,"briefSummary":525,"conditions":526,"keywords":527,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":530,"lastUpdatePostDateStruct":531,"startDateStruct":533,"completionDateStruct":535,"leadSponsor":536,"locationsCount":80},"100532937","effect-of-high-intensity-training-on-motor-and-cognitive-functions-100532937","NCT06219304","Effect of High Intensity Training on Motor and Cognitive Functions","Evaluation of the Impact of Experimentally Induced Fatigability on Motor and Cognitive Functions. Effect of High Intensity Training on Motor and Cognitive Functions:a Pilot Randomized Controlled Trial","FAST","Inclusion Criteria:\n\n* More than 18 years of age\n* Clinical diagnosis of Multiple Sclerosis (MS)\n* Stable disease course without worsening more than 1 EDSS point over the last 3 months, -EDSS between 1.5 and 6 points\n* Must be able to maintain upright posture without any assistance for 30 seconds\n* Must be able to release a written informed consent.\n\nExclusion Criteria:\n\n* MS relapse within the previous three months;\n* Unable to comprehend the aims of the study and to follow test instructions;\n* Diagnosis of major depression (DSM-5);\n* Severe joint and\u002For bone disorders interfering with balance and gait (based upon clinical judgment);\n* Cardiovascular diseases;\n* Unconfirmed or uncertain diagnosis of MS (McDonald criteria)\n* Other concomitant neurological disease;\n* Patients already performing aerobic or walking exercise.",{"count":361,"type":22},[25],"Fatigability is one of the most prevalent disorder in MS followed by walking, balance and cognitive disorders.\n\nHowever, there are few experimental studies on the effects of fatigability on balance and gait hampering the knowledge of causal fatigue-related changes of walking, balance and cognition. Nowadays, instrumented systems such as wearable devices and optoelectronic systems are available and can be used to provide quantitative and objective indexes useful to monitor the changes of gait parameters during a fatiguing performance. (Moreover), instrumented assessment of patients' performances in dual task paradigms can reveal the possible impact of fatigability on cognitive functions. So far, high intensity functional training has been already used in MS to reduce fatigability. However, the true impact of reduced fatigability on walking, balance and cognition has not been assessed after a fatiguing task making impossible to understand the real impact of treatments focusing on fatigability on these functions.\n\nThus, the aims of the present proposal are to assess the: 1) the acute effect of experimentally induced motor fatigability on walking, balance and cognitive functions using an objective instrumented assessment before, during, and after an overground fatiguing walking test. 2) to investigate the effect of high intensity multimodal functional training to improve motor and cognitive disorders.",[438],[528,529],"fatigue","balance","2025-07-07",{"date":532,"type":34},"2025-07-08",{"date":534,"type":34},"2023-09-01",{"date":378,"type":22},{"name":40,"class":41},{"id":538,"slug":539,"hasResults":12,"nctId":540,"briefTitle":541,"officialTitle":542,"acronym":543,"eligibilityCriteria":544,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":545,"targetDuration":4,"studyType":23,"phases":547,"briefSummary":548,"conditions":549,"keywords":550,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":553,"lastUpdatePostDateStruct":554,"startDateStruct":556,"completionDateStruct":558,"leadSponsor":560,"locationsCount":561},"100591283","telerehabilitation-with-digital-technologies-for-the-continuum-of-care-of-stroke-patients-100591283","NCT06978413","Telerehabilitation With Digital Technologies for the Continuum of Care of Stroke Patients","Telerehabilitation With Digital Technologies for the Continuum of Care of Stroke Patients: a Multicentre Randomized Controlled Trial on Effectiveness, Acceptability, Usability, and Economic Sustainability","StrokeHomeFit4","Inclusion Criteria:\n\n* Diagnosis of first ischemic or hemorrhagic stroke verified by Computed Axial Tomography or MRI.\n* Age greater than 18 years.\n* Latency since the event: a) greater than 3 months and less than or equal to 6 months; b) greater than 6 months and less than 24 months.\n* Ability to perform the Timed Up and Go Test.\n\nExclusion Criteria:\n\n* Unstable clinical conditions.\n* Behavioral\u002Fcognitive disorders that prevent adequate patient compliance with the study (severe cognitive impairment, Montreal Cognitive Assessment\\\u003C17.5).\n* Severe visual impairment that cannot be corrected by lenses, preventing the patient from performing treatment with digital instruments.\n* Refusal to sign informed consent.",{"count":546,"type":22},160,[25],"The goal of the pragmatic study is to evaluate the effectiveness of a home-based telerehabilitation protocol for patients with post-stroke disabilities, compared to a home-based educational program.\n\nThe main question it aims to answer is:\n\nIs home-based neuromotor and cognitive rehabilitation using digital tools more effective than a traditional educational program for improving static and dynamic balance in patients with subacute and chronic stroke? Researchers will compare the outcome (Berg Balance Scale) measured at baseline with the outcome after treatment to test its effectiveness.",[95],[100,128,551,552],"digital technologies","home-based","2025-05-26",{"date":555,"type":34},"2025-05-30",{"date":557,"type":34},"2025-05-20",{"date":559,"type":22},"2026-07-31",{"name":40,"class":41},13,{"id":563,"slug":564,"hasResults":12,"nctId":565,"briefTitle":566,"officialTitle":567,"acronym":4,"eligibilityCriteria":568,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":569,"targetDuration":4,"studyType":23,"phases":570,"briefSummary":571,"conditions":572,"keywords":573,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":577,"lastUpdatePostDateStruct":578,"startDateStruct":580,"completionDateStruct":582,"leadSponsor":584,"locationsCount":109},"100587474","study-on-the-effects-of-an-emg-controlled-functional-electrical-stimulator-for-upper-limb-for-post-stroke-patients-100587474","NCT06928857","Study on the Effects of an EMG-controlled Functional Electrical Stimulator for Upper Limb for Post-stroke Patients","Pilot Study on the Effects Induced by an Electromyographic-controlled Functional Electrical Stimulator (FitFES) for Upper Limb Rehabilitation in Post-stroke Patients","Inclusion Criteria:\n\n* 18 years or older\n* Diagnosis of first ischemic or hemorrhagic unilateral stroke for at least two weeks\n* Medical Research Council score for at least one upper limb muscle greater than 0 and less than 5 (excluding extremes).\n* Signed informed consent\n\nExclusion Criteria:\n\n* Score at the Mini Mental State Examination (adjusted for age and schooling) \\\u003C 24\n* Clinical evidence in the case of visual disturbance, ideomotor apraxia, behavioral disorders, neglect, sensory, visual and auditory disturbances of severe degree or otherwise that prevent use of the device\n* Major head trauma\n* Cardio-respiratory or internal clinical instability\n* State of pregnancy or lactation\n* Severe spasticity (Ashworth \\> 3)\n* Skin integrity problems at the interface surface with the device\n* Implanted electronic devices\n* Epilepsy not medically controlled\n* Severe peripheral neuropathy\n* Recent interventions\n* Thrombosis, thrombophlebitis\n* Active stent carrier less than six months\n* Severe forms of arteriosclerosis, arterial circulatory disorders\n* Hypertension not treated\n* Cardiac arrhythmias\n* Hemorrhagic disorders (hemophilia)\n* Severe forms of diabetes mellitus\n* Known allergy to materials making up the device or its applied parts\n* Cancer or tumour disease\n* Acute arthritis\n* Other neurological diseases other than stroke\n* Progressive muscular dystrophy\n* Abdominal or inguinal hernias\n* Undiagnosed back pain\n* Diseases of internal organs",{"count":311,"type":22},[25],"Upper limb disabilities are among the most debilitating issues after a cerebral stroke. One promising approach in motor rehabilitation is the use of functional electrical stimulation (FES). This technique can be integrated into daily therapy to follow an adaptive approach, exploiting the residual capacities of patients. FES can help to stimulate the affected muscles, improve coordination and strengthen the weakened muscles, thus supporting the rehabilitation process.",[95],[574,575,576],"EMG-controlled Functional Electrical Stimulation","Stroke rehabilitation","Medical device","2025-04-14",{"date":579,"type":34},"2025-04-15",{"date":581,"type":34},"2025-03-03",{"date":583,"type":22},"2025-12",{"name":40,"class":41},{"id":586,"slug":587,"hasResults":12,"nctId":588,"briefTitle":589,"officialTitle":590,"acronym":591,"eligibilityCriteria":592,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":593,"targetDuration":4,"studyType":23,"phases":594,"briefSummary":595,"conditions":596,"keywords":4,"overallStatus":166,"whyStopped":4,"lastUpdateSubmitDate":598,"lastUpdatePostDateStruct":599,"startDateStruct":601,"completionDateStruct":602,"leadSponsor":604,"locationsCount":80},"100586832","cognitive-rehabilitation-with-virtual-reality-in-parkinson-disease-100586832","NCT06920511","Cognitive Rehabilitation With Virtual Reality in Parkinson Disease","Integrated biO-cooPErative Robotic plAtform for Virtual Cognitive-motor Training in Parkinson's Disease","OPERA","Inclusion Criteria:\n\n* Diagnosis of mild Parkinson's Disease (Hoehn \\& Yahr stage II-III);\n* Diagnosis of Mild Cognitive Impairment (MCI) according to Litvan et al. (2012) criteria for PD-MCI;\n* Age ≥ 18 years;\n* Signed informed consent\n\nExclusion Criteria:\n\n* Diagnosis of Parkinson's Disease Dementia, atypical parkinsonisms, secondary parkinsonisms, or mixed forms;\n* Severe depressive syndrome\n* Absence of signed informed consent",{"count":233,"type":22},[25],"The OPERA Clinical Study is an interventional, single-arm, open-label pilot clinical study that aims to evaluate the usability of an innovative bio-cooperative robotic platform (PRoBio) for cognitive rehabilitation in patients with Parkinson's Disease (PD) and Mild Cognitive Impairment (MCI). The study focuses on assessing the effectiveness and acceptability of the system in a pilot study involving patients undergoing a structured cognitive rehabilitation program.\n\nPRoBio is an advanced rehabilitation platform that integrates the TIAGo robotic system, developed by PAL Robotics, with the VRRS COMPACT virtual reality rehabilitation system, designed by Khymeia. TIAGo is provided by a robotic arm and RGB-D camera that allow the collection of biomechanical and psychophysiological data, which are then used to personalize the treatment through the cognitive tasks provided by the VRRS COMPACT. The pilot study involves patients with PD-MCI, who will undergo a four-week rehabilitation program with ProBio, consisting of three weekly sessions of virtual cognitive training. The primary objective is to assess the usability and compliance of the system by evaluating user experience, ease of interaction, and engagement levels among both patients and rehabilitation professionals, as well as evaluating its ability to monitor biomechanical and psychophysiological parameters during treatment. This assessment will be conducted using a multimodal sensor system, which includes an RGB-D camera integrated into the UCBM TIAGo robot and wearable sensors designed to measure heart rate, respiratory rate, and galvanic skin response. The data collected through these sensors will be analyzed offline to personalize cognitive rehabilitation treatments in subsequent sessions. Additionally, the study aims to evaluate the accuracy and response times of patients while performing cognitive exercises, as recorded by the VRRS system. Furthermore, the study will explore the potential effects of PRoBio treatment on the cognitive functions of patients with Parkinson's Disease and Mild Cognitive Impairment (PD-MCI) as a possible future rehabilitation to include in the clinical practice.",[597,124],"Parkinson Desease","2025-04-03",{"date":600,"type":34},"2025-04-09",{"date":511,"type":22},{"date":603,"type":22},"2025-07-31",{"name":40,"class":41},{"id":606,"slug":607,"hasResults":12,"nctId":608,"briefTitle":609,"officialTitle":610,"acronym":611,"eligibilityCriteria":612,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":613,"targetDuration":4,"studyType":153,"phases":4,"briefSummary":615,"conditions":616,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":255,"lastUpdatePostDateStruct":619,"startDateStruct":621,"completionDateStruct":623,"leadSponsor":625,"locationsCount":80},"100586478","predictive-variables-of-outcome-in-subjects-with-chronic-rachialgia-referred-to-different-pathways-of-physiotherapy-100586478","NCT06915896","Predictive Variables of Outcome in Subjects With Chronic Rachialgia Referred to Different Pathways of Physiotherapy.","Predictive Variables of Outcome in Subjects With Chronic Rachialgia Referred to Different Pathways of Physiotherapy: Multicenter Prospective Study","PRE-CBP","Inclusion Criteria:\n\n* Age of majority;\n* Medical diagnosis of nonspecific low back pain or nonspecific neck pain;\n* Chronic symptoms, present for at least 6 months;\n* Waiting for rehabilitation in a public health pathways\n* Signature of informed consent to participate in the study and processing of personal data.\n\nExclusion Criteria:\n\n* Subjects with cognitive impairment",{"count":614,"type":22},200,"The aim of this study is to investigate the predictive value of various biopsychosocial variables on the outcomes of subjects with chronic spinal pain undergoing public health rehabilitation pathways. Secondly, the study aims to assess the reliability of certain questionnaires, classified as Patient-Reported Outcome Measures (PROMs), which are frequently used in the evaluation of spinal pain but whose metric properties have not yet been established. These objectives will be pursued through two comprehensive assessment sessions (before and after rehabilitation), a re-test session immediately before rehabilitation (to evaluate the reliability of the questionnaires in stable subjects), and two follow-up assessments at 3 and 6 months after discharge.",[617,618],"Chronic Non-Specific Low Back Pain","Chronic Non-specific Neck Pain",{"date":620,"type":34},"2025-04-08",{"date":622,"type":34},"2023-10-30",{"date":624,"type":22},"2026-05-01",{"name":40,"class":41},{"id":627,"slug":628,"hasResults":12,"nctId":629,"briefTitle":630,"officialTitle":631,"acronym":632,"eligibilityCriteria":633,"healthyVolunteers":12,"sex":18,"minAge":634,"maxAge":183,"enrollmentInfo":635,"targetDuration":4,"studyType":23,"phases":637,"briefSummary":638,"conditions":639,"keywords":643,"overallStatus":166,"whyStopped":4,"lastUpdateSubmitDate":255,"lastUpdatePostDateStruct":648,"startDateStruct":649,"completionDateStruct":651,"leadSponsor":653,"locationsCount":80},"100584525","robotic-rehabilitation-scenario-for-patients-with-neglect-100584525","NCT06890481","Robotic rEhabilitation sCenario fOr patieNts With NeglECT","Collaborative Development of a Virtual Reality Scenario, Integrated Into a Robotic Upper Limb Rehabilitation Device, for the Treatment of Unilateral Spatial Negligence (NSU) Through Mutisensory Stimulation: Feasibility and Usability Pilot Study","RECONNECT","Inclusion Criteria:\n\n* Presence of a diagnosis of right hemispheric stroke\n* Presence of a diagnosis of hemi-inattention (Apple test)\n* Presence of left hemiplegia (Fugl-Meyer Assessment Upper Limb ≤58)\n* Adjusted Montreal Cognitive Assessment \\\u003C20\n* Written informed consent\n\nExclusion Criteria:\n\n* Presence of cognitive decline prior to the event\n* Presence of previous stroke events\n* Presence of osteoarticular rigidity (e.g., ankylosis, functional limitations with traumatic or degenerative origin) or spasticity in the affected upper limb (Modified Ashworth Scale ≥3 on shoulder, elbow, or wrist)\n* Inability to maintain a sitting position\n* Presence of severe visual disabilities\n* Recent injection of botulinum toxin in the upper limb or planned injection of botulinum toxin during the study period\n* Orthopaedic, neurological, or psychiatric disorders that could interfere with the study procedures and motor or cognitive assessments\n* Unstable fractures of the upper limb\n* Severe osteoporosis\n* Skin lesions on the upper limb","20 Years",{"count":636,"type":22},12,[25],"The goal of this pilot clinical trial is to develop an integrated motor and cognitive rehabilitation program and evaluate the usability and acceptability of a new virtual reality scenario designed for the MOTORE device. This study will focus on the rehabilitation of the upper limbs in post-stroke patients with plegia and left-sided hemi-inattention. The main questions it aims to answer are:\n\n* The evaluation of the usability and acceptability of the newly developed scenario\n* The evaluation of the effects of the new scenario on patients' hemi-inattention\n* The evaluation of changes in upper limb functional parameters\n\nParticipants will undergo a total of 13 rehabilitation sessions, each lasting 45 minutes, using the new scenario, including an initial and final assessment.",[95,640,641,642],"Ischemic Stroke","Haemorrhagic Stroke","Neglect, Hemispatial",[192,99,644,645,100,646,647],"end-effector","upper-limbs","neglect","usability",{"date":598,"type":34},{"date":650,"type":22},"2025-04-01",{"date":652,"type":22},"2026-04-01",{"name":40,"class":41},{"id":655,"slug":656,"hasResults":12,"nctId":657,"briefTitle":658,"officialTitle":659,"acronym":4,"eligibilityCriteria":660,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":661,"enrollmentInfo":662,"targetDuration":4,"studyType":153,"phases":4,"briefSummary":663,"conditions":664,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":666,"lastUpdatePostDateStruct":667,"startDateStruct":669,"completionDateStruct":671,"leadSponsor":673,"locationsCount":80},"100371562","validation-fugl-meyer-in-italian-language-fmi-100371562","NCT04117997","Validation Fugl-Meyer in Italian Language (FMI)","Validation of the Evaluation Scale Fugl-Meyer in Italian Language","Inclusion Criteria: 70 individuals with first-ever stroke will be enrolled. Eligible subjects will be in-patients with an acute event occurred no later than 15 days from admission at the \"neurological department \" at the Don Carlo Gnocchi Foundation.\n\nExclusion Criteria:\n\nVisual and\u002F or hearing deficits, amputation of the upper or lower limb, cerebellar stroke; previous strokes (relapse), cognitive decline (MMSE\\\u003C21).","90 Years",{"count":243,"type":22},"The aim of the study is to perform a cultural validation of the Italian translation of the Fugl-Meyer Assessment scale for the upper and the lower limb on a group of post-stroke patients admitted to the neurological department at The Don Carlo Foundation.\n\nThe purpose is to validate the Italian translation of the Fugl-Meyer Assessment scale in order to allow immediate clinical use.",[665],"Validation Fugl-Meyer Scale in Italian","2025-03-28",{"date":668,"type":34},"2025-04-02",{"date":670,"type":34},"2022-11-01",{"date":672,"type":22},"2025-12-01",{"name":40,"class":41},""]