[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Foundation University Islamabad\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":584},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,89,0,25,[9,48,72,93,111,129,147,165,185,201,229,247,273,304,330,352,376,397,415,436,462,488,511,540,566],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":4,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":24,"studyType":25,"phases":4,"briefSummary":26,"conditions":27,"keywords":31,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100618320","retention-of-pits-and-fissure-sealants-on-non-carious-vs-initial-carious-enamel-lesions-in-posterior-teeth-100618320",false,"NCT07330089","Retention of Pits and Fissure Sealants on Non Carious vs Initial Carious Enamel Lesions in Posterior Teeth","Retention of Pits and Fissure Sealants on Non Carious vs Initial Carious Enamel Lesions in Posterior Teeth, a Non Randomized Clinical Study","Inclusion Criteria:\n\n* Fully erupted maxillary and mandibular 1st and 2nd molars with antagonist teeth present.\n* ICDAS score 0,I,II\n* Age 7 to 18 years\n* Both genders included\n\nExclusion Criteria:\n\n* permanent teeth requiring restorations,\n* uncooperative patients\n* patients unwilling for follow-ups\n* molars withy antagonist teeth not present\n* mentally and physically handicapped patients\n* patients with parafunctional habits\n* patients undergoing orthodontic treatments",true,"ALL","7 Years","18 Years",{"count":22,"type":23},420,"ESTIMATED","3 Months","OBSERVATIONAL","This clinical study is planned to be conducted to compare retention rates of pits and fissure sealants on non carious (ICDAS score 0) vs Initial carious enamel lesions (ICDAS Score 1,2) in posterior permeant teeth at 3 months, 6 months and 12 months follow-up. This will help us guide follow-up strategies for optimal caries prevention.",[28,29,30],"Dental Enamel","Dental Enamel Hypomineralization","Dental Enamel Hypoplasia",[32,33,34],"pit and fissure sealants","pit sealant","fissure sealant","RECRUITING","2026-05-22",{"date":38,"type":39},"2026-05-26","ACTUAL",{"date":41,"type":39},"2025-12-27",{"date":43,"type":23},"2027-06-30",{"name":45,"class":46},"Foundation University Islamabad","OTHER",1,{"id":49,"slug":50,"hasResults":12,"nctId":51,"briefTitle":52,"officialTitle":52,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":12,"sex":18,"minAge":54,"maxAge":55,"enrollmentInfo":56,"targetDuration":4,"studyType":58,"phases":59,"briefSummary":61,"conditions":62,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":47},"100634826","effects-of-low-dye-taping-compared-to-calcaneal-taping-in-patients-with-plantar-fasciitis-100634826","NCT07544732","Effects of Low-Dye Taping Compared to Calcaneal Taping in Patients With Plantar Fasciitis","Inclusion Criteria:\n\n* Adults of 19 - 44 years old age.\n* Both genders will be included\n* Pain in plantar heel lasting more than three months\n* Clinical diagnosis of unilateral PF in compliance with the American\n* physical therapy association's (APTA) Orthopedic Section clinical practice\n* guidelines\n* Positive windlass test\n* Negative tarsal tunnel tests\n* Limited active and passive talocrural joint dorsiflexion range of motion\n* Pain on the inner side of the heel is most noticeable with the first steps after\n* rest and tends to worsen after standing or walking for a long time.\n* Willing and capable of adhering to the study procedure and completing follow-up\n* examinations.\n* Planter fascia tests i.e. windlass mechanism, hop test, stair climbing.\n* Sedentary individuals (no exercise plan followed in last 3 months)\n\nExclusion Criteria:\n\n* • Previous surgical intervention for plantar fasciitis.\n\n  * Congenital abnormalities of foot.\n  * Lower extremities affected by systemic disorders, such as rheumatoid arthritis,\n  * diabetes or peripheral neuropathy.\n  * The presence of additional foot disorders, such as stress fractures, Achilles\n  * tendinopathy, or nerve entrapment syndromes.\n  * Any contraindications to taping, such as skin sensitivity or allergy.\n  * Not willing or not capable of adhering to the study procedure and completing follow-\n  * up examinations.\n  * Pregnant women, mental illness, immune suppressed patients, patients with\n  * peripheral vascular disease, thrombocytopenia patients, anti-coagulant therapy\n  * patients and post mastectomy.","19 Years","44 Years",{"count":57,"type":23},40,"INTERVENTIONAL",[60],"NA","Plantar fasciitis is a common musculoskeletal condition characterized by inflammation and microtears of the plantar fascia, leading to heel pain, particularly during initial steps after rest. It negatively impacts gait, mobility, and overall quality of life. Physiotherapy interventions such as stretching, strengthening, electrotherapy, and taping techniques are commonly used for management. Among these, Low-Dye taping and calcaneal taping provide biomechanical support by reducing strain on the plantar fascia and improving foot posture; however, comparative evidence between the two is limited.\n\nThis study aims to evaluate the effectiveness of Low-Dye taping versus calcaneal taping in reducing pain and improving foot function in patients with plantar fasciitis. A total of 36 participants will be randomly assigned to either intervention group and treated over a two-week period. Outcome measures will include pain (VAS), functional ability (FFI), ankle range of motion (goniometer), and gait analysis, assessed before and after intervention. Data will be analyzed using SPSS v27, with statistical significance set at p \\\u003C 0.05.",[63],"Plantar Fascia","2026-05-18",{"date":66,"type":39},"2026-05-20",{"date":68,"type":23},"2026-05-19",{"date":70,"type":23},"2026-07-15",{"name":45,"class":46},{"id":73,"slug":74,"hasResults":12,"nctId":75,"briefTitle":76,"officialTitle":76,"acronym":4,"eligibilityCriteria":77,"healthyVolunteers":12,"sex":78,"minAge":79,"maxAge":80,"enrollmentInfo":81,"targetDuration":4,"studyType":58,"phases":83,"briefSummary":84,"conditions":85,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":89,"startDateStruct":90,"completionDateStruct":91,"leadSponsor":92,"locationsCount":47},"100633388","additional-effects-of-mulligan-mobilization-with-movement-along-with-core-strengthening-exercises-in-postpartum-females-with-sacroiliac-joint-dysfunction-100633388","NCT07526038","Additional Effects of Mulligan Mobilization With Movement Along With Core Strengthening Exercises in Postpartum Females With Sacroiliac Joint Dysfunction","Inclusion Criteria:\n\n* Postpartum females(both normal delivery \\& C-section) aged 20-40 years\n* Parity level: Multiparous\n* Duration: 6 weeks to 6 months postpartum\n* At least three Positive SIJ provocation tests (e.g., stork test, compression, distraction, thigh thrust, Ganslen's and sacral thrust)\n\nExclusion Criteria:\n\n* Pelvic fractures or recent surgery\n* Neurological or rheumatologic disorders\n* Inability to participate in active exercise or manual therapy due to medical or psychological reasons","FEMALE","20 Years","40 Years",{"count":82,"type":23},48,[60],"This study aims to evaluate the combined effectiveness of Mulligan mobilization and core strengthening exercises in managing postpartum sacroiliac joint dysfunction (SIJD). Postpartum SIJD is a common condition resulting from biomechanical and hormonal changes during pregnancy, often leading to pelvic instability and pain. Mulligan mobilization, a manual therapy technique, aims to correct joint alignment and restore pain-free movement. For the SIJ, Mulligan MWM aims to correct subtle positional faults or movement restrictions that may cause pain and dysfunction-especially common postpartum due to ligamentous laxity, hormonal changes, and altered biomechanics.The core muscles provide stability to the pelvis and lumbar spine. When these muscles are weak or imbalanced, it can lead to increased strain on the SIJ, contributing to pain and dysfunction. Strengthening the core improves load transfer through the pelvis and enhances neuromuscular control, thereby reducing SIJ stress and symptoms. Core strengthening exercises enhances outcomes by targeting both mechanical alignment and muscular stability. Core strengthening exercises target muscles that support pelvic stability, including the transverse abdominis and pelvic floor. The study hypothesizes that integrating Mulligan mobilization with core strengthening may provide superior outcomes in pain reduction, joint function, and overall quality of life compared to core exercises alone.",[86,87,88],"Sacro Iliac Joint Pain","Post Partum","Strength Training",{"date":66,"type":39},{"date":66,"type":23},{"date":70,"type":23},{"name":45,"class":46},{"id":94,"slug":95,"hasResults":12,"nctId":96,"briefTitle":97,"officialTitle":97,"acronym":4,"eligibilityCriteria":98,"healthyVolunteers":12,"sex":18,"minAge":99,"maxAge":100,"enrollmentInfo":101,"targetDuration":4,"studyType":58,"phases":103,"briefSummary":104,"conditions":105,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":107,"startDateStruct":108,"completionDateStruct":109,"leadSponsor":110,"locationsCount":47},"100633389","effects-of-autogenic-inhibition-versus-reciprocal-inhibition-in-individuals-with-lower-cross-syndrome-100633389","NCT07526051","Effects of Autogenic Inhibition Versus Reciprocal Inhibition in Individuals With Lower Cross Syndrome","Inclusion Criteria:\n\n* Both Males and Females will be included in our study Age 25-50 years Four positive screening tests (Thomas Test, Abdominal Strength Test, Glutues Maximus Test, Ely's Test) chronic Pain in lower Back Region (\\>3 on VAS) lasting for more than 2 months\n\nExclusion Criteria:\n\n* Osteoporosis Congenital Hip Dysplasia History of Fracture History of Inflammatory Arthritis Pregnancy","25 Years","50 Years",{"count":102,"type":23},72,[60],"This study examines the effects of autogenic inhibition (PFS) versus reciprocal inhibition in individuals with lower cross syndrome",[106],"Lower Cross Syndrome",{"date":66,"type":39},{"date":66,"type":23},{"date":70,"type":23},{"name":45,"class":46},{"id":112,"slug":113,"hasResults":12,"nctId":114,"briefTitle":115,"officialTitle":115,"acronym":4,"eligibilityCriteria":116,"healthyVolunteers":12,"sex":18,"minAge":79,"maxAge":117,"enrollmentInfo":118,"targetDuration":4,"studyType":58,"phases":119,"briefSummary":120,"conditions":121,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":125,"startDateStruct":126,"completionDateStruct":127,"leadSponsor":128,"locationsCount":47},"100633386","comparative-effects-of-post-isometric-relaxation-versus-active-isolated-stretch-in-patients-with-piriformis-syndrome-100633386","NCT07526012","Comparative Effects Of Post Isometric Relaxation Versus Active Isolated Stretch In Patients With Piriformis Syndrome","Inclusion Criteria:\n\n* Age between 20-55 years\n* Both genders\n* Buttock pain that may radiates to posterior thigh but not beyond the knee\n* Pain aggravated by sitting, climbing stairs or hip rotation.\n* Tenderness upon palpation over the sciatic foramen.\n* Positive FAIR test.\n\nExclusion Criteria:\n\n* Malignancies\n* History of steroid therapy over 3 months\n* Rheumatoid arthritis or osteoarthritis\n* Avascular necrosis of the femoral head\n* Osteoporosis\n* Fracture of the femur\n* Hip deformity","55 Years",{"count":57,"type":23},[60],"The purpose of this study is to evaluate the comparative effects of post-isometric relaxation (PIR) and active isolated stretch (AIS) techniques on reducing pain, improving range of motion, and decreasing functional disability in individuals with piriformis syndrome. A total of 40 participants will be recruited, aged 20-55 yrs, with confirmed piriformis syndrome. Participants will be randomized into two equal groups. Group A (post isometric relaxation) and Group B (active isolated stretch). Both groups will receive Conventional Therapy (Thermotherapy, Electrotherapy).\n\nStudy variables include:\n\n* Independent Variable: Post Isometric Relaxation and Active Isolated Stretching.\n* Dependent Variables: Pain (measured by Visual Analog Scale), Functional Disability (assessed via Oswestry Disability Index), Range of Motion (assessed via Goniometer).\n* Control Variables: Age, Gender, BMI, Baseline Pain\u002F Disability Scores\u002FROM\n\nThe intervention will last 2 weeks with 6 sessions (3 sessions per week). Assessments will be conducted at baseline (Week 1, Pre-treatment) and Post every second session. Data will be analyzed to compare immediate and short-term effects of the two interventions.\n\nThis study aims to provide evidence for targeted manual therapy approaches in priformis syndrome, potentially guiding clinicians toward the most effective technique for pain reduction, improve ROM and decrease functional disability.",[122,123,124],"Piriformis Syndrome","Low Back Pain","Hip Joint",{"date":66,"type":39},{"date":66,"type":23},{"date":70,"type":23},{"name":45,"class":46},{"id":130,"slug":131,"hasResults":12,"nctId":132,"briefTitle":133,"officialTitle":133,"acronym":4,"eligibilityCriteria":134,"healthyVolunteers":12,"sex":18,"minAge":20,"maxAge":135,"enrollmentInfo":136,"targetDuration":4,"studyType":58,"phases":138,"briefSummary":139,"conditions":140,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":142,"startDateStruct":143,"completionDateStruct":144,"leadSponsor":146,"locationsCount":47},"100633387","comparative-effects-of-eye-cervical-re-education-exercises-and-pressure-biofeedback-training-of-deep-cervical-flexors-in-cervicogenic-headache-100633387","NCT07526025","Comparative Effects Of Eye-Cervical Re-Education Exercises And Pressure Biofeedback Training Of Deep Cervical Flexors In Cervicogenic Headache","Inclusion Criteria:\n\n* Age 18 to 45 years\n* Both genders\n* Unilateral neck pain and referred headache\n* Headache is precipitated by neck movements or sustained positions.\n* Positive cervical flexion rotation test\n* Headache reproduced with provocation of the involved upper cervical segments.\n* Restricted upper cervical segmental mobility.\n\nExclusion Criteria:\n\n* • Cervical radiculopathy\n\n  * Known or suspected vestibular disorders such as BBPV (Benign Paroxysmal Positional Vertigo), vestibular neuritis, meniere's disease, labyrinthitis\n  * Visual problems such as occipital neuralgia\n  * History of traumatic neck injury\u002Fsurgery or cervical instability\n  * Rheumatoid arthritis\n  * Osteoporosis\n  * Metabolic disorders\n  * Spinal infection or tumors\n  * Vertebrobasilar insufficiency\n  * Other headache types such as tension headache, migraine etc","45 Years",{"count":137,"type":23},34,[60],"Cervicogenic headache (CGH) is a secondary headache that originates from dysfunction in the upper cervical spine, particularly the atlanto-occipital and C1-C3 segments, and is perceived in one or more regions of the head and\u002For face. The underlying mechanism involves convergence of cervical and trigeminal afferents in the trigeminocervical nucleus. Structures innervated by the C1, C2, and C3 spinal nerves are capable of producing referred pain to the head. CGH is relatively common, accounting for approximately 15-20% of all chronic headaches. It typically worsens with neck movement and is often associated with limited cervical range of motion. One of the key impairments in individuals with CGH is disrupted cervical sensorimotor control, particularly affecting proprioception and deep cervical muscle coordination. Physical therapy is widely recognized as the first-line treatment for CGH, with emerging evidence supporting interventions aimed at improving cervical proprioception and neuromuscular control. This study aims to compare the effectiveness of two sensorimotor-based physical therapy approaches-eye-cervical re-education and pressure biofeedback training of deep cervical flexors (DCF)-in patients with CGH. The primary outcomes include pain intensity, functional disability, cervical range of motion (ROM), and cervical joint position sense (proprioception). Participants will be recruited using purposive sampling from Fauji Foundation Hospital and Foundation University College of Physical Therapy (FUCP), Islamabad. After providing written informed consent, eligible participants will be randomized into two groups. Group 1 will receive conventional physical therapy along with eye-cervical re-education exercises, while Group 2 will receive conventional therapy combined with pressure biofeedback DCF training. Data will be collected at baseline and after the 10th treatment session to assess within- and between-group changes in the outcome measures. This study aims to inform evidence-based physical therapy practice in the management of cervicogenic headache.",[141],"Cervicogenic Headache",{"date":66,"type":39},{"date":68,"type":23},{"date":145,"type":23},"2026-06-15",{"name":45,"class":46},{"id":148,"slug":149,"hasResults":12,"nctId":150,"briefTitle":151,"officialTitle":151,"acronym":4,"eligibilityCriteria":152,"healthyVolunteers":12,"sex":18,"minAge":99,"maxAge":135,"enrollmentInfo":153,"targetDuration":4,"studyType":58,"phases":154,"briefSummary":155,"conditions":156,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":159,"lastUpdatePostDateStruct":160,"startDateStruct":161,"completionDateStruct":163,"leadSponsor":164,"locationsCount":47},"100639395","comparative-effects-of-autogenic-inhibition-and-reciprocal-inhibition-technique-on-pain-functional-disability-and-gait-in-sacroiliac-joint-dysfuction-100639395","NCT07600359","Comparative Effects of Autogenic Inhibition and Reciprocal Inhibition Technique on Pain, Functional Disability and Gait in Sacroiliac Joint Dysfuction.","Inclusion Criteria:\n\n* Patients having low back pain greater than 4 weeks\n* Patients with positive gaenslen's test, thigh thurst test, standing flexion test, sacral compression and distraction test.\n* Patients not having any other condition that can affect gait\n* 25-45 years\n* Both males and females\n\nExclusion Criteria:\n\n* Patients having nonspecific low back\n* Patients with lumbosacral fusion\n* Patients with any neurological condition\n* Patients with history of trauma of spine\n* Patients with any other lumbar spine condition (lumbar radiculopathy, spinal stenosis, spondylolisthesis, inflammatory arthritis)\n* Patients with any hip joint pathology\n* Patients using any assistive device",{"count":57,"type":23},[60],"Sacro-iliac joint act as the shock absorber of the body. It is responsible for transferring vertical load of the whole body to lower limb hence contributing to stability of pelvic girdle. However, SI joint dysfunction is one of the most common causes of low back pain among the patients suffering from non-radicular low back pain. There can be a mechanical source which is due to muscle insufficiency or instability or a non-mechanical source which is osteoarthritis, infection or any trauma. It is thought to affect females more commonly with prevalence of about 46.71% in females and with the prevalence of about 15 to 30% in general. This poses great threat to bio mechanics of the body which can significantly lead to disability that can affect mobility, daily activities and quality of life of the individual. According to a study the pain caused by SIJD caused activity limitation and participation restriction of about 25% of the individuals. Hence making it difficult for them to continue their jobs. increased pain leads to worsening of the ability to perform ADLs which ultimately effects the quality of life. Altered biomechanics also leads to alteration in spatio temporal gait parameters.This study aims to compare the effects of autogenic inhibition technique and reciprocal inhibition technique in addition with conventional therapy in reliving low back pain, improving functional disability and alteration in spatio-temporal gait parameters in patients with sacroiliac joint dysfunction. Patients with SIJD will be recruited and will be randomly divided into two groups 20 in each group. Group 1 will receive autogenic inhibition technique of iliopsas, hamstrings, erector spinae and piriformis muscles along with standard core stabilization exercises and group 2 will receive reciprocal inhibition technique on iliopsas, hamstrings, erector spinae and piriformis muscles along with standard core stabilization exercises. The treatment will be continued for 3 weeks with 4 sessions of 25 minutes per week.",[157,158],"Sacroiliac Joint Dysfunction","Muscle Energy Techniques","2026-05-14",{"date":66,"type":39},{"date":162,"type":23},"2026-05-15",{"date":70,"type":23},{"name":45,"class":46},{"id":166,"slug":167,"hasResults":12,"nctId":168,"briefTitle":169,"officialTitle":169,"acronym":4,"eligibilityCriteria":170,"healthyVolunteers":12,"sex":78,"minAge":79,"maxAge":80,"enrollmentInfo":171,"targetDuration":4,"studyType":58,"phases":173,"briefSummary":174,"conditions":175,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":179,"lastUpdatePostDateStruct":180,"startDateStruct":181,"completionDateStruct":183,"leadSponsor":184,"locationsCount":47},"100640273","comparing-the-effects-of-lumbar-stability-exercises-and-telerehabilitation-on-reducing-lumbar-lordotic-angle-pain-and-disability-in-postpartum-women-100640273","NCT07593183","Comparing the Effects of Lumbar Stability Exercises and Telerehabilitation on Reducing Lumbar Lordotic Angle, Pain, and Disability in Postpartum Women","Inclusion Criteria:\n\n* Female participants 6 weeks up to 12 month post-partum women.\n* Participants who has access to internet services and technologies\n* Participants with mild-to-moderate self-reported low back pain for at least 2 weeks.\n* Objectively measured lumbar lordotic angle beyond normative range of 40 Degree\n\nExclusion Criteria:\n\n* Congenital spine deformities like scoliosis\n* Pelvic prolapsed",{"count":172,"type":23},38,[60],"Low back pain is the most common symptoms experienced by people throughout the world. Although lifetime prevalence of low back pain among women is more but it is particularly common during pregnancy, affecting approximately 50% of women. Pregnancy induces significant physiological changes, which lead to increased ligamentous laxity that may persist for 3 to 6 months postpartum. Additionally, the expanding uterus shifts the maternal center of gravity anteriorly, resulting in compensatory lumbar hyperlordosis and contributing to lower back discomfort. While these adaptations help accommodate pregnancy, they often do not fully resolve after birth, especially in the presence of abdominal muscle weakness. The result is altered posture characterized by an exaggerated lumbar lordotic curve that may predispose postpartum women to continued pain and lumbar instability. Without a structured postpartum rehabilitation program, these postural abnormalities may go uncorrected. Ensuring adherence and completion of such programs is critical for preventing long-term musculoskeletal complication. There are many efficient way to help in maintaining adherence and completion of program including the use of digital platforms. The increasing availability of low cost internet and communication technologies has enhanced the capacity to deliver healthcare services through internet, enabling broader access to physiotherapy services and follow-up care through telerehabilitation. Telerehabilitation is one of the emerging field of telemedicine, defined as set of tools, procedure, and protocols to deliver the rehabilitation process remotely. The objective of the study is to facilitate implementation of the telerehabilitation for home based program for postpartum female. The objectives of the study is to compare the effectiveness of telerehabilitation-based lumbar stability exercises versus on-site lumbar stability exercises in improving lumbar stability among postpartum female and to facilitate implementation of the telerehabilitation for home based program for postpartum female. It is a randomized controlled trial. Participants meeting the inclusion criteria will be recruited and consent form will be taken than participants will be allocated to group A (On-Site Lumbar Stability exercise) and B (Telerehabilitation) through 1:1 method. Pre-treatment assessment will be carried out on Day 1 using the outcome measures tool like NPRS, ODI and LLA. Participant will receive intervention for 6 weeks, 3 sessions per weeks. After the completion, on 6 week Post-treatment assessment will be carried out using the same outcome measures tool like NPRS, ODI and LLA.",[176,177,178],"Lumbar Lordotic Angle","Lumbar Pain","Disability","2026-05-12",{"date":64,"type":39},{"date":182,"type":23},"2026-05-13",{"date":70,"type":23},{"name":45,"class":46},{"id":186,"slug":187,"hasResults":12,"nctId":188,"briefTitle":189,"officialTitle":189,"acronym":4,"eligibilityCriteria":190,"healthyVolunteers":12,"sex":18,"minAge":20,"maxAge":80,"enrollmentInfo":191,"targetDuration":4,"studyType":58,"phases":192,"briefSummary":193,"conditions":194,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":179,"lastUpdatePostDateStruct":197,"startDateStruct":198,"completionDateStruct":199,"leadSponsor":200,"locationsCount":47},"100638450","comparative-effects-of-suboccipital-muscle-inhibition-vs-instrument-assisted-soft-tissue-mobilization-in-forward-head-posture-100638450","NCT07593235","Comparative Effects of Suboccipital Muscle Inhibition vs Instrument Assisted Soft Tissue Mobilization in Forward Head Posture","Inclusion Criteria:\n\n* Both genders\n* Age: 18-40 years\n* Increased upper thoracic spine kyphosis\n* Craniovertebral angle CVA of \\\u003C 52°\n\nExclusion Criteria:\n\n* Cervical radiculopathy\n* Neurological deficit\n* Previous surgery of cervical or thoracic spine\n* Spondylolisthesis\n* Spinal stenosis\n* Rheumatoid arthritis\n* Vertebrobasilar artery insufficiency\n* Congenital deformities like kyphosis, scoliosis.",{"count":172,"type":23},[60],"Forward Head Posture (FHP) is a prevalent postural dysfunction characterized by anterior displacement of the head relative to the shoulder line. It is often linked to musculoskeletal pain, restricted cervical mobility, and altered muscle activation patterns. The condition manifests with shortening of the upper trapezius, suboccipital muscles, semispinalis, splenius capitis, Sternocleidomastoid (SCM), and levator scapulae. Concurrently, there is weakness or inhibition in the deep cervical flexors, resulting in an imbalance between the cervical flexor and extensor muscle groups. These muscular imbalances contribute to dysfunctional cervical movement patterns, altered proprioception, and increased joint loading, particularly at the atlanto-occipital and cervico-thoracic junctions. The objective of this randomized controlled trial is to compare the effectiveness of Sub-Occipital Muscle Inhibition (SMI) and Instrument Assisted Soft Tissue Mobilization (IASTM) in improving postural alignment, reducing pain, and enhancing cervical range of motion in individuals with Forward Head Posture. It will address a common postural and musculoskeletal problem that affects a large portion of the population which will contribute to a more effective management approach for Forward Head Posture and will guide clinicians in selecting targeted, evidence-based therapies for their patients with FHP. As there is a lack of comparative studies assessing their relative effectiveness specifically for FHP, it will contribute novel data to the field of physiotherapy and rehabilitation science. A total of 38 participants with FHP will be randomly assigned into two equal groups (n=19). Group A will receive conventional physiotherapy along with Sub-Occipital Muscle Inhibition, while Group B will receive conventional physiotherapy combined with Instrument Assisted Soft Tissue Mobilization. Both groups will undergo 18 treatment sessions over six weeks, administered on alternate days. Both interventions are expected to show positive outcomes in improving FHP; however, the study aims to determine which technique is more effective. The results will help clinicians understand which manual therapy methods work best. This can make it easier for them to choose the right treatment for Forward Head Posture. Using proven techniques can improve patient comfort and recovery. In the end, it will help to provide advance approach and more personalised care for the patients.",[195,196],"Forward Head Posture","Occipital Muscle Inhibition Technique",{"date":64,"type":39},{"date":182,"type":23},{"date":70,"type":23},{"name":45,"class":46},{"id":202,"slug":203,"hasResults":12,"nctId":204,"briefTitle":205,"officialTitle":205,"acronym":4,"eligibilityCriteria":206,"healthyVolunteers":12,"sex":18,"minAge":117,"maxAge":207,"enrollmentInfo":208,"targetDuration":4,"studyType":58,"phases":210,"briefSummary":211,"conditions":212,"keywords":215,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":179,"lastUpdatePostDateStruct":224,"startDateStruct":225,"completionDateStruct":227,"leadSponsor":228,"locationsCount":47},"100638095","effects-of-kinect-based-exergaming-versus-wii-fit-training-on-balance-and-fall-risk-among-healthy-older-adults-100638095","NCT07596225","Effects of Kinect-Based Exergaming Versus Wii Fit Training on Balance and Fall Risk Among Healthy Older Adults","Inclusion Criteria:\n\n* Older adults aged ≥55, community-dwelling, with a BBS score between 21-50, including both mild to moderate Risk falls\n* Able to stand without assistive devices\n* Cognitively able to follow instructions, with a MoCA score ≥ 22\n* Both Genders: Males and females\n\nExclusion Criteria:\n\n* History of Neurological disorders affecting balance (e.g., Parkinson's disease, stroke)\n* Acute Vestibular disorders\u002FMajor Musculoskeletal impairments (e.g., Arthritis)\n* Participation in other balance training programs within the past 6 months\n* Any condition posing a safety risk (e.g., severe osteoporosis, uncontrolled hypertension","85 Years",{"count":209,"type":23},46,[60],"Study, titled Effects of Kinect-Based Exergaming versus Wii Fit on Balance and Fall Risk among Healthy Older Adults, is a randomized controlled trial comparing the balance training effects of Xbox Kinect and Wii Fit.\n\nAfter obtaining informed consent, 46 healthy older adults will be randomly allocated (1:1) using sealed envelopes to a 6-week training program in either group. Static, Dynamic, and Anticipatory balance will be assessed at baseline and post-intervention using the Biodex Balance System for objective comparison.",[213,214],"Balance","Fall Risk",[216,217,218,219,220,221,222,223],"Postural Balance","Postural Control","Accidental Falls","Risk factors","Aged","virtual reality","video games","rehabilitation",{"date":68,"type":39},{"date":226,"type":23},"2026-05-05",{"date":70,"type":23},{"name":45,"class":46},{"id":230,"slug":231,"hasResults":12,"nctId":232,"briefTitle":233,"officialTitle":233,"acronym":4,"eligibilityCriteria":234,"healthyVolunteers":12,"sex":18,"minAge":20,"maxAge":80,"enrollmentInfo":235,"targetDuration":4,"studyType":58,"phases":236,"briefSummary":237,"conditions":238,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":240,"lastUpdatePostDateStruct":241,"startDateStruct":243,"completionDateStruct":245,"leadSponsor":246,"locationsCount":47},"100639097","impairment-oriented-versus-task-oriented-gait-training-in-transfemoral-amputee-rehabilitation-100639097","NCT07578051","Impairment Oriented Versus Task Oriented Gait Training In Transfemoral Amputee Rehabilitation.","Inclusion Criteria:\n\n* Age 18-40 years\n* Unilateral transfemoral amputees\n* Cleared by physicians for participation in physical therapy\n* Willing\n\nExclusion Criteria:\n\n* Residual limb complication that interfere with mobility\n* History of neurological disorders\n* Any joint complication in intact limb\n* Currently enrolled in another research study\n* Mild to severe cognitive impairment (MoCA) i.e , score less than 25 , Uncontrolled diabetes",{"count":57,"type":23},[60],"This study examines the comparison between Impairment Oriented versus Task Oriented Gait Training in Transfemoral Amputee Rehabilitation. A randomized controlled trial conducted with 40 participants divided into two groups .Both groups receive pre-gait training and corrective walking exercises for 10 days .",[239],"Transfemoral Amputees","2026-05-04",{"date":242,"type":39},"2026-05-11",{"date":244,"type":23},"2026-05-06",{"date":70,"type":23},{"name":45,"class":46},{"id":248,"slug":249,"hasResults":12,"nctId":250,"briefTitle":251,"officialTitle":251,"acronym":4,"eligibilityCriteria":252,"healthyVolunteers":12,"sex":18,"minAge":253,"maxAge":254,"enrollmentInfo":255,"targetDuration":4,"studyType":58,"phases":256,"briefSummary":257,"conditions":258,"keywords":260,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":266,"lastUpdatePostDateStruct":267,"startDateStruct":269,"completionDateStruct":271,"leadSponsor":272,"locationsCount":47},"100637053","additional-effect-of-coherent-breathing-with-aerobic-exercise-on-cardiopulmonary-parameters-and-quality-of-life-in-stage-1-hypertensive-individuals-100637053","NCT07573683","Additional Effect of Coherent Breathing With Aerobic Exercise on Cardiopulmonary Parameters and Quality of Life in Stage 1 Hypertensive Individuals","Inclusion Criteria:\n\n* Both male and female genders.\n* Adults aged 30-65 years.\n* Patients diagnosed with stage 1 hypertension 130-139\u002F80-89mm Hg according to ACC\u002FAHA 2017 guidelines.\n* Mild to moderate physical activity level on IPAQ questionnaire.\n* Individuals able to understand and follow the instructions.\n\nExclusion Criteria:\n\n* Diagnosed uncontrolled hypertensive patients.\n* Unstable angina, MI, heart failure, advanced CAD patients, COPD, Asthma.\n* Severe neurological, musculoskeletal or gynecological conditions which limit participation in the study.\n* Recent history of fracture.","30 Years","65 Years",{"count":57,"type":23},[60],"This study will use a randomized controlled trial to evaluate the added effects of coherent breathing combined with aerobic exercise versus aerobic exercise alone in 40 adults aged 30-65 with stage 1 hypertension. Participants will be randomly assigned to an intervention group (aerobic exercise plus coherent breathing) or a control group (aerobic exercise only) and will undergo a 4-week program with 5 sessions per week.\n\nCardiopulmonary parameters-including blood pressure, heart rate, respiratory rate, and rate pressure product-will be measured, and quality of life will be assessed using the MINICHAL questionnaire at baseline, 2 weeks, and post-intervention. Data will be analyzed using SPSS version 21.0.\n\nThe study aims to determine whether coherent breathing provides additional benefits, offering a cost-effective, non-pharmacological strategy for hypertension management in low-resource settings.",[259],"Stage 1 Hypertensives",[259,261,262,263,264,265],"Breathing","Aerobic Exercises","Cardiopulmonary parameters","Coherent breathing technique","Quality of life","2026-05-01",{"date":268,"type":39},"2026-05-07",{"date":270,"type":39},"2026-02-28",{"date":162,"type":23},{"name":45,"class":46},{"id":274,"slug":275,"hasResults":12,"nctId":276,"briefTitle":277,"officialTitle":278,"acronym":279,"eligibilityCriteria":280,"healthyVolunteers":12,"sex":18,"minAge":281,"maxAge":282,"enrollmentInfo":283,"targetDuration":4,"studyType":58,"phases":285,"briefSummary":286,"conditions":287,"keywords":289,"overallStatus":295,"whyStopped":4,"lastUpdateSubmitDate":296,"lastUpdatePostDateStruct":297,"startDateStruct":299,"completionDateStruct":301,"leadSponsor":303,"locationsCount":47},"100634395","investigating-the-efficacy-of-oral-probiotics-versus-placebo-in-pakistani-patients-with-moderate-acne-on-acne-lesion-count-and-systemic-inflammation-100634395","NCT07539129","Investigating the Efficacy of Oral Probiotics Versus Placebo in Pakistani Patients With Moderate Acne on Acne Lesion Count and Systemic Inflammation","A Randomized Controlled Trial Investigating the Efficacy of Oral Probiotics Versus Placebo in Pakistani Patients With Moderate Acne on Acne Lesion Count and Systemic Inflammation (Interleukin-6) Levels","Acne vulgaris","Inclusion Criteria:\n\n* Male and female patients aged 15-35 years\n* Clinical diagnosis of moderate acne vulgaris\n* Fitzpatrick skin types III-V\n* Willing to provide informed consent and comply with study protocol\n\nExclusion Criteria:\n\n* Severe nodulocystic acne, acne conglobata, or acne fulminans\n* Oral antibiotics, isotretinoin, or hormonal therapy within past 4 weeks\n* Topical anti-acne therapy within past 2 weeks\n* Current probiotic supplementation\n* Chronic inflammatory or autoimmune disease\n* Pregnancy or lactation","15 Years","35 Years",{"count":284,"type":23},64,[60],"This randomized controlled trial evaluates the efficacy of oral probiotics compared to placebo in Pakistani patients with moderate Acne Vulgaris. Acne is a multifactorial inflammatory disorder influenced by microbial colonization, seborrhea, and immune dysregulation. Rising antibiotic resistance necessitates alternative therapeutic approaches. Emerging evidence highlights the gut-skin axis, suggesting probiotics may reduce systemic inflammation and acne severity. A total of 64 patients will be randomized into probiotic and placebo groups and treated for 12 weeks. The primary outcome is reduction in total acne lesion count, while the secondary outcome is change in serum Interleukin-6 levels. Clinical assessment includes lesion counts, GAGS scoring, and standardized photography. IL-6 levels will be measured using ELISA at baseline and study completion. Data will be analyzed using SPSS with appropriate statistical tests, considering p ≤ 0.05 as significant. This study aims to provide evidence for probiotics as a safe, effective, and antibiotic-sparing option in acne management, particularly in South Asian populations.",[288],"Acne Vulgaris",[288,290,291,292,293,294],"Modrate Acne","Probiotics","Inflammatory markers","Interleukin 6","Ecotec TM","NOT_YET_RECRUITING","2026-04-13",{"date":298,"type":39},"2026-04-20",{"date":300,"type":23},"2026-09-01",{"date":302,"type":23},"2027-08-01",{"name":45,"class":46},{"id":305,"slug":306,"hasResults":12,"nctId":307,"briefTitle":308,"officialTitle":308,"acronym":4,"eligibilityCriteria":309,"healthyVolunteers":12,"sex":18,"minAge":80,"maxAge":254,"enrollmentInfo":310,"targetDuration":4,"studyType":58,"phases":311,"briefSummary":312,"conditions":313,"keywords":315,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":324,"lastUpdatePostDateStruct":325,"startDateStruct":327,"completionDateStruct":328,"leadSponsor":329,"locationsCount":47},"100633829","comparative-effect-of-pursed-lip-breathing-alone-and-combined-with-alternate-nostril-breathing-on-pulmonary-function-test-and-quality-of-life-in-patients-in-grade-i-copd-patients-100633829","NCT07531771","Comparative Effect of Pursed Lip Breathing Alone and Combined With Alternate Nostril Breathing on Pulmonary Function Test and Quality of Life in Patients in Grade I COPD Patients.","Inclusion Criteria:\n\n* Patients diagnosed with Grade I COPD (FEV₁ \\> 80% predicted)\n* Age between 40 to 65 years.\n* Both male and female patients.\n* Patients able to follow verbal instructions and perform breathing exercises.\n* Patients willing to provide written informed consent.\n\nExclusion Criteria:\n\n* History of orthopedic conditions limiting sitting or breathing exercises.\n* Recent respiratory infections or COPD exacerbations within the past 4 weeks.\n* Neurological or cognitive impairments.\n* Recent thoracic or abdominal surgeries.\n* Regular practitioners of yoga or alternate nostril breathing.",{"count":57,"type":23},[60],"Chronic Obstructive Pulmonary Disease (COPD) is a progressive respiratory disorder characterized by airflow limitation, breathlessness, and reduced quality of life. Breathing exercises are commonly used in pulmonary rehabilitation to improve respiratory efficiency and functional capacity. Among these techniques, pursed lip breathing (PLB) helps slow expiration, reduce air trapping, and improve ventilation, while alternate nostril breathing (ANB), a yogic breathing technique, may enhance respiratory control and relaxation.\n\nThe purpose of this study is to determine the effects of pursed lip breathing alone compared with the combined effect of pursed lip breathing and alternate nostril breathing on pulmonary function and quality of life in patients with Grade I COPD. This randomized controlled trial will include approximately 40 participants diagnosed with mild COPD. The participants will be divided into two groups: one group will perform pursed lip breathing exercises, while the other group will perform a combination of pursed lip breathing and alternate nostril breathing.\n\nPulmonary function tests and quality of life assessments will be used as outcome measures to evaluate the effectiveness of these interventions. The study aims to determine whether combining both breathing techniques provides greater improvement in respiratory function and patient well being than pursed lip breathing alone. The findings may contribute to developing more effective physiotherapy based pulmonary rehabilitation strategies for patients with COPD.",[314],"COPD Grade I",[316,317,318,319,320,321,322,323],"COPD","breathing","exercise","pursed lip breathing","alternate nostril breathing","pulmonary functions","chest expansion","quality of life","2026-04-12",{"date":326,"type":39},"2026-04-15",{"date":270,"type":39},{"date":162,"type":23},{"name":45,"class":46},{"id":331,"slug":332,"hasResults":12,"nctId":333,"briefTitle":334,"officialTitle":334,"acronym":4,"eligibilityCriteria":335,"healthyVolunteers":12,"sex":18,"minAge":80,"maxAge":254,"enrollmentInfo":336,"targetDuration":4,"studyType":58,"phases":337,"briefSummary":338,"conditions":339,"keywords":341,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":346,"lastUpdatePostDateStruct":347,"startDateStruct":349,"completionDateStruct":350,"leadSponsor":351,"locationsCount":47},"100632806","additional-effects-of-box-breathing-technique-with-short-term-pulmonary-rehabilitation-on-dyspnea-and-functional-capacity-in-patients-with-chronic-obstructive-pulmonary-disease-100632806","NCT07518472","Additional Effects of Box Breathing Technique With Short Term Pulmonary Rehabilitation on Dyspnea and Functional Capacity in Patients With Chronic Obstructive Pulmonary Disease","Inclusion Criteria:\n\n* Age between 40-65 years\n* Both genders (male and female)\n* Grade 1-3 on mMRC scale of dyspnea\n* COPD mild stage according to global initiative for chronic obstructive lung -disease (GOLD) classification; Mild = FEV1 greater than or equal to 80% predicted\n\nExclusion Criteria:\n\n* Patients having acute exerbation of COPD\n* Patients diagnosed with acute infection (pmeumonia, T.B)\n* Any orthopedic or neuromuscular condition that hinders participation in exercise training program\n* Patients unable to follow command and instructions",{"count":57,"type":23},[60],"Chronic Obstructive Pulmonary Disease is progressive and irreversible respiratory condition characterized by persistent airflow limitation leading to dyspnea and reduced functional capacity.\n\nPulmonary rehabilitation along with different technqiues of breathing exercises reduces dyspnea and enhance functional capacity by improving ventilatory efficiency, respiratory muscle control and overall exercise tolerance in patients with COPD.",[340],"Pulmonary Disease, Chronic Obstructive (COPD)",[316,342,343,344,345],"Short term pulmonary rehabilitation","box breathing","dyspnea","functional capacity","2026-04-07",{"date":348,"type":39},"2026-04-08",{"date":270,"type":39},{"date":162,"type":23},{"name":45,"class":46},{"id":353,"slug":354,"hasResults":12,"nctId":355,"briefTitle":356,"officialTitle":356,"acronym":4,"eligibilityCriteria":357,"healthyVolunteers":12,"sex":18,"minAge":79,"maxAge":117,"enrollmentInfo":358,"targetDuration":4,"studyType":58,"phases":360,"briefSummary":361,"conditions":362,"keywords":364,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":346,"lastUpdatePostDateStruct":370,"startDateStruct":372,"completionDateStruct":374,"leadSponsor":375,"locationsCount":47},"100633680","additional-effects-of-pilates-breathing-and-diaphragmatic-breathing-combined-with-moderate-intensity-continuous-cycling-training-on-blood-pressure-chest-expansion-pulmonary-function-and-quality-of-life-in-patients-with-hypertension-100633680","NCT07529834","Additional Effects of Pilates Breathing and Diaphragmatic Breathing Combined With Moderate Intensity Continuous Cycling Training on Blood Pressure, Chest Expansion, Pulmonary Function and Quality Of Life in Patients With Hypertension","Inclusion Criteria:\n\n* Medically diagnosed patients having Stage 1 hypertension(SBP;140-159 mmHg,DBP:90-99mmHg) and Stage 2 -hypertension(SBP:≥160mmHg,DBP:≥100mmHg) according to JNC 8 Guidelines, referred by a medical specialist or GP or cardiologist from FFH or clinical setups or Hospitals of Rawalpindi\u002FIslambad\n* Patients who are on antihypertensive medications for at least 3 months before study.\n* Age ranging from 20-55 years\n* Both male and female patients.\n* Patients who are willing to participate in exercise regime and are able to -provide informed consent, have not been a part of any exercise regime from the last 6 months and well tolerated for exercise after being screened through PAR-Q+\n\nExclusion Criteria:\n\n* Patients with Stage 3 hypertension (SBP: ≥180 mmHg or DBP: ≥110 mmHg) and above hypertension according to JNC 8 Guidelines or Hypertensive Crisis etc.\n* Patients with any severe knee or other orthopedic conditions that can limit exercise performance\n* Patients with uncontrolled hypertension\n* History of any abdominal, orthopedic or spinal surgery that could interfere with core or breathing exercise\n* Neurological or psychiatric disorders\n* Uncontrolled cardiovascular conditions such as arrhythmias or recent myocardial infarction\n* Pregnant women",{"count":359,"type":23},45,[60],"Hypertension or high blood pressure is defined as when the pressure in the blood vessels is too high. According to Joint National Committee 8 (JNC 8) Guidelines, hypertension is defined as systolic blood pressure level of more than ≥ 140 mmHg and diastolic blood pressure ≥ 90 mmHg. This study aims to study the combined effects of Pilates breathing, Diaphragmatic breathing and Moderate Intensity Continuous Cycling Training on blood pressure, chest expansion, pulmonary function and quality of life. Aerobic physical activity moderate intensity continuous training: (55%- 70% of maximal heart rate (MHR), rate of perceived exertion (RPE) of 11-13 on the Borg scale) continuous training, known as MICT. Pilates breathing exercise enhances lung expansion by focusing on controlled rhythmic breathing methods involving respiratory muscles. Diaphragmatic breathing exercise is slow and controlled deep breathing that has important effects on respiratory system by the modulation of autonomic nervous system. Hypertensive patients will be selected for this study. The study will include three groups. One group will undergo Cycling training with Pilates breathing and the other group will undergo Cycling training with Diaphragmatic breathing and third group will undergo Cycling training only. Before initiating the intervention at the baseline, following outcome measures would be assessed for all the patients: Blood pressure, chest expansion, pulmonary function and quality of life.",[363],"Hypertension",[363,365,366,367,368,369,265],"Pilates Breathing","Diaphragmatic Breathing","Cycling training","Pulmonary Function","Chest expansion",{"date":371,"type":39},"2026-04-14",{"date":373,"type":39},"2026-01-12",{"date":162,"type":23},{"name":45,"class":46},{"id":377,"slug":378,"hasResults":12,"nctId":379,"briefTitle":380,"officialTitle":380,"acronym":4,"eligibilityCriteria":381,"healthyVolunteers":12,"sex":18,"minAge":20,"maxAge":135,"enrollmentInfo":382,"targetDuration":4,"studyType":58,"phases":383,"briefSummary":384,"conditions":385,"keywords":387,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":346,"lastUpdatePostDateStruct":393,"startDateStruct":394,"completionDateStruct":395,"leadSponsor":396,"locationsCount":47},"100633681","comparative-effects-of-alternative-nostril-breathing-versus-buteyko-breathing-on-control-pause-dyspnea-and-pulmonary-function-in-patients-with-bronchial-asthma-100633681","NCT07529847","Comparative Effects of Alternative Nostril Breathing Versus Buteyko Breathing on Control Pause, Dyspnea and Pulmonary Function in Patients With Bronchial Asthma","Inclusion Criteria:\n\n* Age between 18-45 years\n* Both genders (male and female)\n* Grade 1-3 on mMRC scale of dyspnea\n* Asthma severity classes- intermediate,mild persistent and moderate persistent asthma (acc. to NAEPP National Asthma Education and Prevention Program guidlines 2020)\n\nExclusion Criteria:\n\n* Patients having acute exerbation of COPD\u002Fstatus asthmaticus\n* Patients diagnosed with acute infection\n* Patients unable to follow command and instructions\n* Asthma patients with \\>40sec control pause duration",{"count":209,"type":23},[60],"Bronchial asthma is a chronic inflmmatory airway disease characterized by recurrent episodes of dyspnea, wheezing, and airflow limitation.\n\nDysfunctional breathing pattern and chronic hyperventilation",[386],"Asthma (Diagnosis)",[388,389,390,344,391,392],"Bronchial asthma","alternative nostril breathing","buteyko breathing","pulmonary function","asthma control",{"date":371,"type":39},{"date":270,"type":39},{"date":162,"type":23},{"name":45,"class":46},{"id":398,"slug":399,"hasResults":12,"nctId":400,"briefTitle":401,"officialTitle":401,"acronym":4,"eligibilityCriteria":402,"healthyVolunteers":12,"sex":18,"minAge":79,"maxAge":117,"enrollmentInfo":403,"targetDuration":4,"studyType":58,"phases":404,"briefSummary":405,"conditions":406,"keywords":408,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":346,"lastUpdatePostDateStruct":411,"startDateStruct":412,"completionDateStruct":413,"leadSponsor":414,"locationsCount":47},"100633679","additional-effects-of-pilates-breathing-and-diaphragmatic-breathing-combined-with-moderate-intensity-continuous-treadmill-training-on-blood-pressure-chest-expansion-pulmonary-function-and-quality-of-life-in-pre-hypertensive-patients-100633679","NCT07529821","Additional Effects of Pilates Breathing and Diaphragmatic Breathing Combined With Moderate Intensity Continuous Treadmill Training on Blood Pressure, Chest Expansion, Pulmonary Function and Quality Of Life in Pre-hypertensive Patients","Inclusion Criteria:\n\n* Prehypertensive individuals (SBP 120-139 mmHg or DBP 80-89 mmHg)\n* Age 20-55 years\n* Both male and female\n* Sedentary individuals according to IPAQ\n* Willing to participate and provide informed consent\n\nExclusion Criteria:\n\n* Diagnosed hypertension (≥140\u002F90 mmHg)\n* Cardiopulmonary diseases (COPD, asthma, CAD, heart failure)\n* Musculoskeletal conditions preventing exercise\n* Neurological disorders\n* Pregnancy\n* Participation in structured exercise in last 3 months",{"count":359,"type":23},[60],"Pre-hypertension is defined as systolic blood pressure between 120-139mmHg or diastolic blood pressure between 80-89mmHg and is considered a risk factor for developing hypertension. Early lifestyle interventions such as aerobic exercise and breathing techniques may help prevent progression to hypertension. This randomised controlled trial aims to determine the additional effects of pilates breathing and diaphragmatic breathing combined with moderate-intensity continuous treadmill training on blood pressure, chest expansion, pulmonary function and quality of life in pre-hypertensive patients.\n\nA total of 45 participants will be randomly allocated into three groups:\n\ntreadmill training with pilates breathing, tredmill training with diaphragmtic brething and treadmill training alone. The intervention will be conducted for 6 weeks. Outcome measures including blood pressure, pulmonary function, chest expansion and quality of life will be assesed before and after the intervention.",[407],"PRE-HYPERTENSION",[409,365,366,410,368,369,265],"Pre-hypertension","Treadmill training",{"date":371,"type":39},{"date":270,"type":39},{"date":162,"type":23},{"name":45,"class":46},{"id":416,"slug":417,"hasResults":12,"nctId":418,"briefTitle":419,"officialTitle":419,"acronym":4,"eligibilityCriteria":420,"healthyVolunteers":12,"sex":18,"minAge":20,"maxAge":99,"enrollmentInfo":421,"targetDuration":4,"studyType":58,"phases":423,"briefSummary":424,"conditions":425,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":429,"lastUpdatePostDateStruct":430,"startDateStruct":431,"completionDateStruct":433,"leadSponsor":435,"locationsCount":47},"100633379","immediate-effect-of-dry-needling-on-calf-muscles-pain-pressure-thresholdsprint-speed-and-functional-performance-in-amateur-football-player-100633379","NCT07525921","Immediate Effect of Dry Needling on Calf Muscles Pain Pressure Threshold,Sprint Speed and Functional Performance in Amateur Football Player","Inclusion Criteria:\n\n* Amateur football players aged 18-25 years.\n\nParticipation in club-level football for at least one year.\n\nPresence of active myofascial trigger point in gastrocnemius or soleus confirmed by palpation.\n\nWillingness to participate and provide informed consent.\n\nExclusion Criteria:\n\n* History of calf muscle tear, fracture, or lower limb surgery.\n\nCurrent use of muscle relaxants or anti-inflammatory medication.\n\nKnown bleeding disorders or anticoagulant therapy.\n\nLocal infection, skin lesion, or contraindication to dry needling.\n\nNeurological or vascular disorders affecting lower limb function.",{"count":422,"type":23},60,[60],"This randomised single-blind trial will evaluate the immediate effect of a single session of dry needling versus sham needling on calf muscle myofascial trigger points among amateur football players aged 18-25 years. Primary and secondary outcomes are Pressure Pain Threshold (algometer), Sprint Speed (shuttle run test), and Functional Performance (single-leg hop). Outcomes will be measured immediately pre- and post-intervention. Data analysis will be performed in SPSS version 27 using paired and independent t-tests (p \\\u003C 0.05).",[426,427,428],"Myofascial Pain Syndromes","Trigger Points","Gastrocnemius Muscle","2026-04-06",{"date":296,"type":39},{"date":432,"type":39},"2025-08-29",{"date":434,"type":23},"2026-06-01",{"name":45,"class":46},{"id":437,"slug":438,"hasResults":12,"nctId":439,"briefTitle":440,"officialTitle":440,"acronym":441,"eligibilityCriteria":442,"healthyVolunteers":12,"sex":18,"minAge":443,"maxAge":79,"enrollmentInfo":444,"targetDuration":4,"studyType":58,"phases":445,"briefSummary":446,"conditions":447,"keywords":449,"overallStatus":295,"whyStopped":4,"lastUpdateSubmitDate":455,"lastUpdatePostDateStruct":456,"startDateStruct":458,"completionDateStruct":459,"leadSponsor":461,"locationsCount":47},"100632860","a-randomized-controlled-trial-comparing-the-effectiveness-and-safety-of-topical-tacrolimus-003-versus-crisaborole-2-in-patients-with-mild-to-moderate-atopic-dermatitis-over-8-weeks-100632860","NCT07519174","A Randomized Controlled Trial Comparing the Effectiveness and Safety of Topical Tacrolimus 0.03% Versus Crisaborole 2% in Patients With Mild to Moderate Atopic Dermatitis Over 8 Weeks","eczema","Inclusion Criteria:\n\nAge 2-20 years Clinically diagnosed mild to moderate AD EASI score ≤21 Informed consent\n\nExclusion Criteria:\n\nSevere AD (EASI \\>21) Use of topical\u002Fsystemic corticosteroids within 2 weeks Secondary infection Known drug hypersensitivity Immunocompromised state","2 Years",{"count":102,"type":23},[60],"This randomized controlled trial compares the effectiveness and safety of topical tacrolimus 0.03% and crisaborole 2% in patients with mild to moderate atopic dermatitis over 8 weeks. Atopic dermatitis is a chronic inflammatory skin condition affecting quality of life, and steroid-sparing treatments are increasingly preferred due to adverse effects of long-term corticosteroid use. Tacrolimus, a calcineurin inhibitor, and crisaborole, a PDE-4 inhibitor, are both effective alternatives, though tacrolimus may offer greater efficacy while crisaborole has better tolerability. The study will include 70 patients aged 2-20 years, randomized into two groups receiving either treatment. Outcomes will be assessed using EASI score reduction and adverse effects. Data will be analyzed statistically to determine significance. The study aims to generate local evidence to guide treatment decisions and improve management strategies for atopic dermatitis in the Pakistani population.",[448],"Atopic Dermatitis",[450,451,452,453,454],"Dermatitis","atopic","tacrolimus","Calcineurin inhibitors","crisaborole","2026-04-02",{"date":457,"type":39},"2026-04-09",{"date":434,"type":23},{"date":460,"type":23},"2027-01-01",{"name":45,"class":46},{"id":463,"slug":464,"hasResults":12,"nctId":465,"briefTitle":466,"officialTitle":467,"acronym":468,"eligibilityCriteria":469,"healthyVolunteers":12,"sex":18,"minAge":20,"maxAge":100,"enrollmentInfo":470,"targetDuration":4,"studyType":58,"phases":472,"briefSummary":473,"conditions":474,"keywords":475,"overallStatus":295,"whyStopped":4,"lastUpdateSubmitDate":480,"lastUpdatePostDateStruct":481,"startDateStruct":483,"completionDateStruct":485,"leadSponsor":487,"locationsCount":47},"100631059","comparative-evaluation-of-topical-metformin-and-topical-tranexamic-acid-in-melasma-100631059","NCT07495748","Comparative Evaluation of Topical Metformin and Topical Tranexamic Acid in Melasma","Comparative Evaluation of Topical Metformin and Topical Tranexamic Acid in Melasma Using MASI Score Reduction: A Randomized Controlled Trial","Melasma","Inclusion Criteria:\n\n* Patients aged 18-50 years\n\n  * Clinically diagnosed facial melasma\n  * Both genders\n  * Patients willing to give informed consent\n\nExclusion Criteria:\n\n* • Pregnant or lactating women\n\n  * Patients using systemic or topical melasma treatments in the previous 4 weeks\n  * Known hypersensitivity to study medications\n  * Presence of other facial dermatoses\n  * History of photosensitivity disorders",{"count":471,"type":23},70,[60],"This randomised controlled trial aims to compare the efficacy of topical metformin (30%) and topical tranexamic acid (3%) in the treatment of melasma using reduction in the Melasma Area and Severity Index (MASI) score over 12 weeks. Melasma is a common hyperpigmentation disorder with significant cosmetic and psychological impact, and current treatments often have limitations. Both metformin and tranexamic acid have shown promising depigmenting effects through different mechanisms. A total of 70 patients will be enrolled and randomly divided into two groups. Participants will apply the assigned treatment once daily along with sunscreen and will be assessed at baseline and at 4, 8, and 12 weeks. The primary outcome is MASI score reduction, while secondary outcomes include patient-reported improvement and safety. This study seeks to provide comparative evidence for safer and more effective treatment options for melasma management.",[468],[468,476,477,478,479],"topical metformin","topical tranexamic acid","hyper-pigmentation","MASI","2026-03-24",{"date":482,"type":39},"2026-03-27",{"date":484,"type":23},"2026-07-01",{"date":486,"type":23},"2027-07-01",{"name":45,"class":46},{"id":489,"slug":490,"hasResults":12,"nctId":491,"briefTitle":492,"officialTitle":493,"acronym":468,"eligibilityCriteria":494,"healthyVolunteers":12,"sex":78,"minAge":282,"maxAge":117,"enrollmentInfo":495,"targetDuration":4,"studyType":58,"phases":497,"briefSummary":498,"conditions":499,"keywords":501,"overallStatus":295,"whyStopped":4,"lastUpdateSubmitDate":504,"lastUpdatePostDateStruct":505,"startDateStruct":507,"completionDateStruct":508,"leadSponsor":510,"locationsCount":47},"100630292","comparative-evaluation-of-topical-30-metformin-and-kligmans-regimen-in-women-with-melasma-100630292","NCT07485777","Comparative Evaluation of Topical 30% Metformin and Kligman's Regimen in Women With Melasma","A Novel Approach to Melasma Management: Comparative Evaluation of Topical 30% Metformin and Kligman's Regimen in Middle-Aged Women","Inclusion Criteria:\n\n* Female patients aged 35-55 years\n* Clinically diagnosed epidermal or dermal melasma (confirmed by Wood's lamp examination)\n* Fitzpatrick skin types III-V\n* Duration of melasma ≥6 months\n* No topical or systemic treatment for melasma in the past month\n\nExclusion Criteria:\n\n* Pregnancy or lactation\n* Known allergy to study medications\n* Active facial dermatitis, acne, or recent cosmetic procedures",{"count":496,"type":23},82,[60],"It's a prospective, randomised, assessor-blinded clinical study comparing topical 30% metformin with Kligman's regimen for melasma in women aged 35-55 years at Fauji Foundation Hospital, Rawalpindi. The study seeks to ascertain which treatment yields a more significant decrease in the modified MASI score over an 8-week period and which treatment is associated with fewer adverse effects, such as erythema, burning, peeling, and post-inflammatory hyperpigmentation. A total of 82 participants will be enrolled and randomly assigned to either metformin cream or Kligman's regimen, with both groups also using sunscreen. Assessments will be done at baseline, week 4, and week 8 through mMASI scoring, photographs, and side-effect monitoring. Data will be analyzed in SPSS 26 using t-tests and chi-square testing. The study is based on evidence suggesting metformin may offer comparable efficacy with better tolerability.",[500,468],"Melasma (Facial Melasma)",[468,476,502,478,503],"kligman regimen","mMASI","2026-03-17",{"date":506,"type":39},"2026-03-20",{"date":484,"type":23},{"date":509,"type":23},"2027-06-01",{"name":45,"class":46},{"id":512,"slug":513,"hasResults":12,"nctId":514,"briefTitle":515,"officialTitle":516,"acronym":4,"eligibilityCriteria":517,"healthyVolunteers":12,"sex":18,"minAge":518,"maxAge":4,"enrollmentInfo":519,"targetDuration":4,"studyType":58,"phases":521,"briefSummary":523,"conditions":524,"keywords":526,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":532,"lastUpdatePostDateStruct":533,"startDateStruct":535,"completionDateStruct":537,"leadSponsor":539,"locationsCount":47},"100629793","phase-1-effect-of-local-use-of-vitamin-d-on-the-rate-of-canine-distillization-a-split-mouth-randomized-control-trial-100629793","NCT07479290","Effect of Local Use of Vitamin D on the Rate of Canine Distillization: a Split Mouth Randomized Control Trial","Effect Of Local Use Of 1,25 Dihydroxycholecalciferol on Rate of Canine Distillization: A Split Mouth Randomized Control Trial","Inclusion Criteria:\n\n* Patient with permanent dentition\n* Angles class 1,class II dental malocclusion, indicated for bilateral maxillary first premolar extraction\n* minimum 5 of extraction space\n\nExclusion Criteria:\n\n* several craniofacial deformities such as cleft lip and palate\n* history of bone disease such as osteoporosis or diabetes\n* pregnant and lactating women","13 Years",{"count":520,"type":23},30,[522],"PHASE1","Orthodontic treatment (OT) is characterized as a lengthy procedure and enormous effort has been harnessed to shorten the OT duration using either surgical or non-surgical approaches. With the emerging concept of \"accelerated orthodontics,\" scientific interest has been focused on chemical and electrical stimuli in combination with mechanical forces for rapid bone turnover and more stable results. Given the role of cytokines, parathyroid hormone, active vitamin D3 (1,25 dihydroxycholecalciferol) in bone regeneration, several studies have been conducted in which exogenous biological molecules have been locally administrated in order to stimulate orthodontic tooth movement.\n\nVitamin D (Vit-D) plays a significant role in bone biology and remodeling.There are two primary forms of Vit-D: 25-OHD (25-hydroxyvitamin D) and 1,25 DHC (1,25-dihydroxycholecalciferol) which is the active form.\n\n1,25 DHC is a potent stimulator of osteoclastic activity by inducing differentiation as well as increasing the activity of osteoclasts. It is also known to work in a dose-dependent way. Although it has a 2-3-hour plasma half-life, its effects on cells might last for days. Injecting the active form of Vitamin D can increase tooth movement, decrease the treatment time of fixed appliances and maintain the integrity of the bone.\n\nIn the past researches have been done on cats and rodents on the effect of intraligamentary administration of vitamin D3 on tooth movement. Studies performed on human beings are few and inconclusive. Two out of the four studies done on humans were cross-sectional and investigated the role of active vitamin D on external apical root resorption. The other two clinical trials used split-mouth technique and examined the impact of local CTL administration on tooth movement rate, both demonstrating level 1 of evidence and high recommendation. Al-Hasani and colleagues reported that a low dose of 25 picogram\u002FmL produced a higher rate of OTM, with no statistically significant difference between the study and control sides in 15 patients involved in the study. However, Iosub Ciur and colleagues reported 70% acceleration in the OTM when using higher 42 picogram\u002FmL local dose of vit D, but the number of patients was extremely low and not adequate(n=4) in this study. The purpose of our study is to evaluate if higher doses of local vitamin D can accelerate tooth movement in adequate number of adult patients. If vitamin D in our population of adult patients can accelerate tooth movement, then it can allow for more predictable treatment outcome during fixed orthodontic therapy.",[525],"Malocclusion of Anterior Teeth",[527,528,529,530,531],"Vitamin D","Malocclusion","accelerated Orthodontics","1,25 dihydroxycholecalciferol","canine distillization","2026-03-16",{"date":534,"type":39},"2026-03-18",{"date":536,"type":39},"2026-02-20",{"date":538,"type":23},"2027-12",{"name":45,"class":46},{"id":541,"slug":542,"hasResults":12,"nctId":543,"briefTitle":544,"officialTitle":545,"acronym":4,"eligibilityCriteria":546,"healthyVolunteers":12,"sex":18,"minAge":79,"maxAge":254,"enrollmentInfo":547,"targetDuration":549,"studyType":25,"phases":4,"briefSummary":550,"conditions":551,"keywords":553,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":557,"lastUpdatePostDateStruct":558,"startDateStruct":560,"completionDateStruct":562,"leadSponsor":564,"locationsCount":565},"100622806","pharmacogenetics-of-leflunomide-in-the-management-of-rheumatoid-arthritis-100622806","NCT07388407","Pharmacogenetics of Leflunomide in the Management of Rheumatoid Arthritis","Pharmacogenetics of Leflunomide in the RA Management","Inclusion Criteria:\n\n* At baseline, all patients should fulfill the revised ACR\u002FEULAR criteria for RA10\n* Pakistani individuals\n* between ages of 20-75 years\n* New cases started on Leflunomide\u002F those already taking for less than a month and their biochemical and clinical data is available\n\nExclusion Criteria:\n\n* Patients not willing to participate\u002F consent not given\n* Patients below the age of 20\n* Non- Pakistani origin\n* Taking another DMARD simultaneously\n* Compromised renal and hepatic functions\n* Cognitive impairment, neurological disease\n* Pregnant\u002F lactating patients\n* Patients having inflammatory bowel disease\u002F Irritable bowel syndrome\n* Patients with active infective diseases -Patients who fail to complete 3 months of leflunomide therapy-",{"count":548,"type":23},110,"2 Months","1. Patients taking leflunomide as the only disease-modifying anti-rheumatic drug (DMARD) will be recruited after consent.\n2. Blood sample for DNA extraction will be taken The patient will be followed up till two visits 3 months apart, and efficacy and toxicity will be checked using DAS28, ultrasonography, and blood tests for ESR, CRP, anti-CCP, liver function tests, etc. The data form for toxicity will be filled.\n3. DNA will be extracted in the laboratory, and SNP will be identified.\n4. The efficacy and toxicity data will be studied against the SNPs found\n5. An algorithm will be constructed for Pakistani RA patients taking leflunomide.",[552],"Rhematoid Arthritis",[554,555,556],"RA","SNP","Leflunomide","2026-01-30",{"date":559,"type":39},"2026-02-05",{"date":561,"type":39},"2024-09-01",{"date":563,"type":23},"2026-09-30",{"name":45,"class":46},2,{"id":567,"slug":568,"hasResults":12,"nctId":569,"briefTitle":570,"officialTitle":570,"acronym":4,"eligibilityCriteria":571,"healthyVolunteers":12,"sex":18,"minAge":20,"maxAge":135,"enrollmentInfo":572,"targetDuration":4,"studyType":58,"phases":573,"briefSummary":574,"conditions":575,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":577,"lastUpdatePostDateStruct":578,"startDateStruct":579,"completionDateStruct":581,"leadSponsor":583,"locationsCount":47},"100618679","non-thrust-lumbar-and-sacral-mobilizations-in-mechanical-low-back-pain-100618679","NCT07334756","Non-Thrust Lumbar and Sacral Mobilizations in Mechanical Low Back Pain","* Inclusion Criteria Adults 18 to 45 years Both genders Low back (from T12 to buttock line) pain for more than 3 months The CMLBP is the chief complaint without leg pain.\n* Exclusion Criteria Acute flare Low Back Pain Thoracic pain Trauma to the spine causing fracture and disruption of the ligaments Leg symptoms when walk, eased in flexion (Signs of stenosis) Paresthesia\u002Fnumbness Structural deformity (scoliosis, spondylosis, spondylolisthesis) Curve reversal Pregnancy Post-surgery (within 6 months of abdominal or spinal\u002Flower limb surgery) Degenerative and inflammatory spinal diseases Malignancy Centralization and peripheralization",{"count":57,"type":23},[60],"This study is a randomized controlled trial and the purpose of this study is to determined the effects of sacral mobilizations along with the lumbar mobilizations in mechanical low back pain on components such as pain , lumbar range of motion, lumbar proprioception and functional disability.",[576],"Mechanical Low Back Pain","2025-12-31",{"date":373,"type":39},{"date":580,"type":39},"2025-01-15",{"date":582,"type":23},"2026-01-15",{"name":45,"class":46},""]