[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Fraser Health\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":113},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,53,81],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":33,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":41,"lastUpdatePostDateStruct":42,"startDateStruct":45,"completionDateStruct":47,"leadSponsor":49,"locationsCount":52},"100581888","a-novel-blood-test-as-a-biomarker-in-mental-health-100581888",false,"NCT06856161","A Novel Blood Test as a Biomarker in Mental Health","A Novel Blood Test as a Differential Diagnosis and Drug Efficacy Biomarker in Mental Health","LEADING-MH","Inclusion Criteria:\n\nI. Age 19+. II. Informed consent by participant\n\nIII. Any of the following situations:\n\n1. Suspected, new onset or established depression.\n2. First episode of psychosis or suspected\u002Festablished schizophrenia. IV. In the opinion of the Investigator, the participant will likely be able to complete the standardized mental health questionnaires administered in each study visit.\n\nExclusion Criteria:\n\nI. Inability to provide informed consent. II. Currently enrolled in any other research study involving drugs or devices that may confound mental health treatment outcomes.\n\nIII. Currently declared on extended leave Under British Columbia's Mental Health Act.","ALL","19 Years",{"count":20,"type":21},500,"ESTIMATED","OBSERVATIONAL","This longitudinal, observational study aims to assess whether the characteristics of a novel blood peripheral biomarker can serve as indicators for depression and schizophrenia in patients at the Royal Columbian Hospital Psychiatric Clinics. The study will evaluate whether changes in these biomarker characteristics can help distinguish between depressed patients who do or do not respond to treatment and between individuals experiencing a single psychotic episode and those at risk of progressing to schizophrenia. To achieve this, blood samples and standardized mental health assessments will be collected across three study visits from up to 500 participants, grouped into two study arms based on their diagnosis: Depression (DEP) or Psychosis\u002FSchizophrenia (PSY).",[25,26,27,28,29,30,31,32],"Depression - Major Depressive Disorder","Schizophenia Disorder","Psychosis","Mania (Neurotic)","Alcohol Consumption","Anxiety Disorder (Panic Disorder or GAD)","Substance Use Disorders","Alcohol Use Disorder",[34,35,36,37,38,39],"mental health","biomarker","depression","schizophrenia","psychosis","SERT","RECRUITING","2026-03-03",{"date":43,"type":44},"2026-03-05","ACTUAL",{"date":46,"type":44},"2025-03-25",{"date":48,"type":21},"2027-08-31",{"name":50,"class":51},"Fraser Health","OTHER",1,{"id":54,"slug":55,"hasResults":11,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":59,"eligibilityCriteria":60,"healthyVolunteers":11,"sex":61,"minAge":18,"maxAge":4,"enrollmentInfo":62,"targetDuration":4,"studyType":64,"phases":65,"briefSummary":67,"conditions":68,"keywords":70,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":4},"100626597","labour-pain-relief-options-video-versus-pamphlet-for-easing-fear-of-birth-and-improving-preparedness-in-pregnant-patients-an-rct-100626597","NCT07437703","Labour Pain Relief Options: Video Versus Pamphlet for Easing Fear of Birth and Improving Preparedness in Pregnant Patients, an RCT","Labour Pain Relief Options: Video Versus Pamphlet for Easing Fear of Birth and Improving Preparedness in Pregnant Patients, a Randomized Controlled Trial","LOVE","Inclusion Criteria:\n\n* Adults age 19 years and over\n* Primiparous patients over 32 weeks of gestation\n* Planning to labour\n\nExclusion Criteria:\n\n* Emergency delivery\u002Falready in labour\n* Patients who are not intending to labour\n* Unable to give consent\n* Unable to communicate in English","FEMALE",{"count":63,"type":21},100,"INTERVENTIONAL",[66],"NA","The goal of this clinical trial is to investigate whether a structured educational video improves outcomes related to fear of birth and patient preparedness for pregnant adults who are planning to labour.\n\nThe primary objective is to evaluate whether an educational video can reduce fear of childbirth more effectively than a pamphlet.\n\nPatients will complete a baseline questionnaire assessing their knowledge of labour pain relief options and their current fear of childbirth. The control group will be provided an electronic version of a pamphlet while the intervention group will watch an educational video outlining pharmacologic and non-pharmacologic options for labour pain relief. Immediately after the intervention, all participants will complete the same questionnaire to assess changes in fear and knowledge.",[69],"Labour Pain",[71],"Labour pain","NOT_YET_RECRUITING","2026-02-24",{"date":75,"type":44},"2026-02-27",{"date":77,"type":21},"2026-04-01",{"date":79,"type":21},"2026-12-31",{"name":50,"class":51},{"id":82,"slug":83,"hasResults":11,"nctId":84,"briefTitle":85,"officialTitle":85,"acronym":86,"eligibilityCriteria":87,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":88,"enrollmentInfo":89,"targetDuration":4,"studyType":64,"phases":91,"briefSummary":93,"conditions":94,"keywords":99,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":104,"lastUpdatePostDateStruct":105,"startDateStruct":107,"completionDateStruct":109,"leadSponsor":111,"locationsCount":112},"100502598","early-phase-1-testing-the-feasibility-of-using-ropivacaine-in-spinal-anesthesia-for-patients-with-lower-back-surgery-100502598","NCT05824338","Testing the Feasibility of Using Ropivacaine in Spinal Anesthesia for Patients With Lower Back Surgery","SASS","Inclusion Criteria:\n\n* Adult patients who are equal to or greater than 18 years old\n* Undergoing elective one or two-level lumbar surgery via posterior surgical approach in the prone position (between L2-S1)\n* Expected surgery duration of no greater than 2 hours\n* ASA Physical Status Class 1 to 3\n* Patient can have either spinal anesthesia or general anesthesia\n* Able to provide consent and understand information in English, and capable of answering questions in English\n\nExclusion Criteria:\n\n* Allergy to either ropivacaine, bupivacaine, or local anesthetics\n* Contraindications to spinal anesthesia (i.e. coagulopathy or on anticoagulants, severe aortic or mitral valve stenosis, sepsis or bacteremia, thrombocytopenia, high intracranial pressure, infection at the puncture site)\n* Surgery is expected to take more than 2 hours\n* Emergency surgery\n* Previously had back surgery at the level of the spine currently being operated on\n* Comorbidities that require the patient to undergo general anesthesia\n* Inability to stay still during the surgery\n* Inability to move legs preoperatively\n* Body Mass Index (BMI) \\>35\n* Multilevel severe spinal stenosis","80 Years",{"count":90,"type":21},45,[92],"EARLY_PHASE1","The goal of this pilot clinical trial is to test the feasibility of conducting a randomized controlled trial that will examine the use of ropivacaine in the spinal anesthesia for patients undergoing elective 1- or 2-level lower spine surgery. This study aims to:\n\n* Determine the rates of eligibility, recruitment, consent, and attrition\n* Determine the acceptability among patients, surgeons, anesthesiologists, and nurses of doing spine surgery under spinal anesthesia\n* Gather preliminary data on outcomes relevant to a future dose-finding study\n\nParticipants will be randomized to one of three treatment groups:\n\n* General anesthesia with endotracheal tube\n* Spinal anesthesia with bupivacaine\n* Spinal anesthesia with ropivacaine",[95,96,97,98],"Anesthesia, Spinal","Neurosurgery","Ropivacaine","Bupivacaine",[100,101,102,103],"Anesthesia","Spinal","Lumbar surgery","Lower back","2024-10-04",{"date":106,"type":44},"2024-10-08",{"date":108,"type":44},"2024-08-27",{"date":110,"type":21},"2025-12-31",{"name":50,"class":51},2,""]