[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Fujian University of Traditional Chinese Medicine\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":68},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,44],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":4},"100618294","based-on-the-spatio-temporal-coding-characteristics-of-frontotemporal-network-this-paper-explores-the-mechanism-of-five-tone-speech-training-in-reshaping-language-fluency-function-100618294",false,"NCT07329751","Based on the Spatio-temporal Coding Characteristics of Frontotemporal Network, This Paper Explores the Mechanism of Five-tone Speech Training in Reshaping Language Fluency Function.","Eligibility Criteria\n\nInclusion Criteria:\n\nAge between 18 and 70 years\n\nRight-handed\n\nNative Chinese speakers\n\nClinical diagnosis of post-stroke aphasia caused by ischemic stroke, confirmed by CT or MRI\n\nDiagnosis of non-fluent aphasia based on the Western Aphasia Battery (WAB), with BDAE severity rating of 1-5\n\nTime since stroke onset ≥ 2 weeks\n\nStable vital signs, clear consciousness, and no severe cognitive impairment\n\nAbility to understand the study procedures and provide written informed consent (or consent provided by a legally authorized representative)\n\nExclusion Criteria:\n\nHistory of aphasia or neurological disease not caused by stroke (e.g., traumatic brain injury, brain tumor, neurodegenerative diseases)\n\nSevere visual or auditory impairments that would interfere with task performance\n\nSevere cognitive impairment or disorders of consciousness preventing cooperation with language assessment or intervention\n\nSevere dysarthria or apraxia of speech that precludes valid language assessment\n\nHistory of epilepsy or other severe neurological conditions\n\nSevere systemic diseases (e.g., severe cardiopulmonary dysfunction, renal failure, hepatic failure, malignancy)\n\nPsychiatric disorders (e.g., schizophrenia, severe depression, or other major psychiatric illnesses)\n\nContraindications to MRI or fNIRS assessment (e.g., metallic implants, severe claustrophobia)",true,"ALL","18 Years","80 Years",{"count":20,"type":21},120,"ESTIMATED","INTERVENTIONAL",[24],"NA","To explore the mechanism of five-tone speech training in reshaping language fluency function and the clinical efficacy of aphasia language function, daily communication ability and communication efficiency based on the temporal and spatial coding characteristics of frontotemporal network. Combined with EEG ( rsEEG, ERP ), nuclear magnetic resonance examination and near-infrared imaging system examination to explore its effect on brain electrophysiological activity. So as to promote the modernization of traditional Chinese medicine rehabilitation treatment technology and the popularization and application of speech rehabilitation treatment technology.",[27],"Aphasia",[29,30,31],"aphasia","stroke","pentatonic scales of chinese medicine","NOT_YET_RECRUITING","2026-01-19",{"date":35,"type":36},"2026-01-21","ACTUAL",{"date":38,"type":21},"2025-12-31",{"date":40,"type":21},"2028-09-30",{"name":42,"class":43},"Fujian University of Traditional Chinese Medicine","OTHER",{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":48,"acronym":4,"eligibilityCriteria":49,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":50,"targetDuration":4,"studyType":52,"phases":4,"briefSummary":53,"conditions":54,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":4},"100559481","to-explore-the-functional-connectivity-pattern-of-cortical-swallowing-network-in-the-oral-phase-of-post-stroke-dysphagia-based-on-dynamic-causal-modelling-100559481","NCT06564688","To Explore the Functional Connectivity Pattern of Cortical Swallowing Network in the Oral Phase of Post-stroke Dysphagia Based on Dynamic Causal Modelling","Inclusion Criteria:\n\n1. Inclusion criteria of patients with post-stroke oral dysphagia:\n\n   * Patients with dysphagia after first stroke, meeting the diagnostic criteria of stroke, and confirmed by brain CT or brain MRI;\n   * Oral dysphagia caused by stroke;\n   * FOIS level ≤ 5; WST level ≥3;\n   * Those who can understand and carry out the simple instructions of the treatment staff and are willing to accept the examination and treatment;\n   * Clear consciousness and stable vital signs;\n   * Patients in the recovery stage with stroke course and dysphagia duration between 0 and 6 months;\n   * Right-handed;\n   * Voluntary participants with informed consent.\n2. Inclusion criteria of patients without dysphagia after stroke:\n\n   * Patients with first-ever stroke, meeting the diagnostic criteria of stroke, and confirmed by brain CT or brain MRI;\n   * No dysphagia, FOIS level =7; WST level =1;\n   * Those who can understand and carry out the simple instructions of the treatment staff and are willing to accept the examination and treatment;\n   * Clear consciousness and stable vital signs;\n   * Patients in the recovery stage with stroke duration between 0 and 6 months;\n   * Right-handed;\n   * Voluntary participants with informed consent.\n3. Inclusion criteria of healthy control group:\n\n   * Normal cognitive function and swallowing function, FOIS level =7; WST level =1;\n   * Gender and age matched with patients with dysphagia in the oral phase after stroke;\n   * Right-handed;\n   * Voluntary participants with informed consent.\n\nExclusion Criteria:\n\n* Dysphagia not caused by stroke or non-oral dysphagia;\n* History of cerebral trauma, stroke, brain tumor, cerebrovascular, intracranial infection, Parkinson's disease, epilepsy, or other neurological or psychiatric diseases;\n* Symptoms of severe aphasia, neglect, visual field defect and other cortical lesions; Patients with severe cognitive impairment or depression;\n* Taking or within 2 weeks of taking drugs that affect the nervous system or psychoses;\n* Patients with metal implants and\u002For spatial claustrophobia who are not suitable for MRI scanning;\n* Visual\u002Fhearing disorders affecting training and assessment;\n* Persons who are participating in other research trials that may influence the results of this study.",{"count":51,"type":21},72,"OBSERVATIONAL","Swallowing activity in the oral phase is regulated by the cortical swallowing network, and the functional connectivity pattern of the cortical swallowing network is related to swallowing activity. The structural damage of the cortical swallowing network and abnormal activation of brain areas related to swallowing in post-stroke dysphagia affect swallowing activity. The recovery of dysphagia after stroke is related to the compensation of swallowing network in the contralateral hemisphere and different connectivity patterns of diseased brain areas, and the integrity of cortical swallowing network connectivity affects the sequence of oral swallowing activities. However, it is not clear how the functional connectivity patterns and interactions of brain regions of the cortical swallowing network related to oral swallowing activity change in patients with oral dysphagia after stroke.",[55,56,57,58,59],"Dysphagia After Stroke","Cortical Swallowing Network","Functional Magnetic Resonance Imaging","Oral Phase","Dynamic Causal Modelling","2024-08-19",{"date":62,"type":36},"2024-08-21",{"date":64,"type":21},"2024-08-20",{"date":66,"type":21},"2025-07-01",{"name":42,"class":43},""]