[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Fundación Cardiovascular de Colombia\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":85},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,53],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":31,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":41,"lastUpdatePostDateStruct":42,"startDateStruct":45,"completionDateStruct":47,"leadSponsor":49,"locationsCount":52},"100595520","effects-of-online-mindfulness-therapy-on-pain-and-stress-in-adults-with-chronic-migraine-and-adverse-childhood-experiences-100595520",false,"NCT07033520","Effects of Online Mindfulness Therapy on Pain and Stress in Adults With Chronic Migraine and Adverse Childhood Experiences","Effects of Online Mindfulness-Based Cognitive Therapy on Pain, Stress-Related Symptoms, and Functionality in Adults With Chronic Migraine and Adverse Childhood Experiences at the International Hospital of Colombia","Inclusion Criteria:\n\n* Male and female patients aged 18 years or older with a diagnosis of chronic migraine according to the International Classification of Headache Disorders (ICHD-3), based on diagnostic criteria updated through 2018.\n* Willingness to participate in online sessions from 6:00 PM to 8:00 PM on the scheduled day of the intervention.\n* Male and female patients with a score of 4 or higher on the Adverse Childhood Experiences Questionnaire.\n* Patients who provide informed consent.\n\nExclusion Criteria:\n\n* Visual, auditory, cognitive, or functional limitations that prevent understanding of therapeutic activities or the ability to perform home tasks.\n* Presence of systemic inflammatory disorders, including rheumatic and autoimmune diseases.\n* Active malignancy.\n* Pregnancy or breastfeeding at the time of the study.\n* Pre-existing neurological conditions (e.g., epilepsy, neuromuscular disorders, metabolic diseases, among others).\n* Central nervous system tumors.\n* Diagnosis of terminal illnesses that prevent follow-up over time.","ALL","18 Years",{"count":19,"type":20},60,"ESTIMATED","INTERVENTIONAL",[23],"NA","This study aims to evaluate the effectiveness of an online Mindfulness-Based Cognitive Therapy (MBCT) program in reducing pain, stress-related symptoms, and improving functionality in adults with chronic migraine and a history of adverse childhood experiences (ACE). Participants will be randomly assigned to either the MBCT intervention group or a control group. The intervention is delivered entirely online over eight weeks. The study hypothesizes that MBCT will result in significant improvements in pain perception and stress-related symptoms compared to the control condition.",[26,27,28,29,30],"Chronic Migraine","Adverse Childhood Experiences","Depression","Anxiety","Headache Disorders",[32,33,34,35,36,37,38,39],"Mindfulness-Based Cognitive Therapy","MBCT","Trauma","Pain","Headache","Online Psychological Intervention","Migraine","Stress-Related Disorders","NOT_YET_RECRUITING","2025-06-23",{"date":43,"type":44},"2025-06-26","ACTUAL",{"date":46,"type":20},"2025-07-01",{"date":48,"type":20},"2025-11-20",{"name":50,"class":51},"Fundación Cardiovascular de Colombia","OTHER",1,{"id":54,"slug":55,"hasResults":11,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":59,"eligibilityCriteria":60,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":61,"enrollmentInfo":62,"targetDuration":4,"studyType":21,"phases":64,"briefSummary":65,"conditions":66,"keywords":72,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":52},"100584872","transcutaneous-auricular-vagus-nerve-stimulation-in-patients-with-stroke-100584872","NCT06895005","Transcutaneous Auricular Vagus Nerve Stimulation in Patients With Stroke","Effectiveness of Transcutaneous Auricular Vagus Nerve Stimulation on Upper Limb Motor Recovery After Stroke","INPULSE","Inclusion Criteria:\n\n* Age \\>18 years and \\\u003C75 years\n* Unilateral supratentorial ischemic stroke that occurred at least 7 days but not more 30 days before enrollment.\n* Modified Rankin Scale between 0 and 1 before stroke\n* Contralesional UL motor impairment defined by NIHSS item 5 score ≥ 1 to ≤ 3.\n* Ability to provide written informed consent.\n* Hemodynamically stable patients.\n* Patients residing in the metropolitan area of Bucaramanga.\n\nExclusion Criteria:\n\n* Significant cognitive or language impairment that would interfere with study participation or informed consent. This criterion will be defined by NIHSS item 1a-c score \\> 2, item 9 score \\> 1, item 11 score = 2.\n* Medical conditions that could interfere with study participation, for example ear infections or skin wounds.\n* Bradycardia (\\\u003C 50 bpm) or hypotension (\\\u003C 90\u002F60 mmHg)\n* Significant pre-existing disability\n* History of stroke\n* History of cardiac arrhythmia\n* History of severe head trauma, brain surgery, deep brain stimulation, or brain injuries of other etiologies.\n* Pregnant or planning on becoming pregnant or breastfeeding during the study period.\n* Medical or mental instability (diagnosis of personality disorder, psychosis, or substance abuse) that would prevent subject from meeting protocol timeline.\n* Subjects who are currently in another clinical trial or plan to do so during the study period.\n* Patient receiving any therapy at study entry that would interfere with VNS (e.g., drugs that interfere with neurotransmitter mechanisms: anticholinergics, adrenergic blockers, etc.).\n* Prior injury to vagus nerve.\n* Any other implanted device such as a pacemaker or other neurostimulator; any other investigational device or drug.","75 Years",{"count":63,"type":20},30,[23],"This study will evaluate the effects of transcutaneous vagus nerve stimulation in combination with physical rehabilitation on upper limb motor function of patients with stroke.",[67,68,69,70,71],"Motor Impairment","Motor Impairments","Stroke","Stroke; Sequelae","Stroke, Ischemic",[69,73,74,75,76],"Vagus nerve","Vagus nerve stimulation","Transcutaneous vagus nerve stimulation","Rehabilitation","2025-03-25",{"date":79,"type":44},"2025-03-30",{"date":81,"type":20},"2025-04-01",{"date":83,"type":20},"2025-12-24",{"name":50,"class":51},""]