[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Fundacion Miguel Servet\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":504},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,16,0,[8,52,90,118,148,177,203,246,273,300,326,362,396,424,450,476],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":32,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":40,"lastUpdatePostDateStruct":41,"startDateStruct":44,"completionDateStruct":46,"leadSponsor":48,"locationsCount":51},"100644269","beetroot-extract-and-quality-of-life-in-adults-aged-75-and-over-100644269",false,"NCT07666685","Beetroot Extract and Quality of Life in Adults Aged 75 and Over","Assessment of the Benefits of Beetroot Extract for Improving the Quality of Life of Older People: a Randomised Clinical Trial.","BERS","Inclusion Criteria:\n\n1. Adults aged 75 years and older recruited from the Geriatrics Service of the Hospital Universitario de Navarra (HUN) or primary care settings.\n2. Ability to ambulate independently.\n3. Ability to communicate effectively.\n4. Ability to tolerate physical exercise.\n5. Barthel Index score greater than 60 points.\n\nExclusion Criteria:\n\n1. Refusal or inability of the participant, caregiver, or legal guardian to provide written informed consent.\n2. Advanced or severe dementia (Global Deterioration Scale \\[GDS\\] stages 6-7).\n3. Unstable medical condition or terminal illness with a life expectancy of less than 6 months.\n4. Ischemic heart disease or congestive heart failure.\n5. Severe renal insufficiency.\n6. Hypotension.",true,"ALL","75 Years",{"count":21,"type":22},120,"ESTIMATED","INTERVENTIONAL",[25],"NA","The increasing number of adults aged 75 years and older highlights the need for effective, low-cost interventions to preserve cardiovascular health, functional independence, and cognitive performance and to support healthy aging. Beetroot extract (BE), derived from \"Beta vulgaris\", contains high levels of inorganic nitrate and other bioactive compounds that may positively influence vascular and neuromuscular function. In parallel, multicomponent physical exercise is recognized as an effective strategy to improve physical and cognitive outcomes in older adults. However, evidence on the independent and combined effects of BE supplementation and structured exercise in very old adults remains limited.\n\nThis randomized controlled trial is designed to evaluate the effects of BE supplementation, alone and in combination with a multicomponent physical exercise program, on blood pressure, functional performance, and cognitive function in adults aged 75 years and older. Participants will be randomly assigned to one of four groups: BE supplementation, multicomponent exercise, combined BE supplementation and exercise, or a control condition, over a predefined intervention period. The exercise program will include strength, balance, mobility, and aerobic components specifically adapted to the abilities and safety requirements of old adults.\n\nThe primary outcomes of the study will assess changes in cardiovascular health, physical and functional performance, and cognitive function using standardized and validated assessment tools. Secondary outcomes will include additional indicators of physical capacity and health-related quality of life. This trial aims to provide clinically relevant evidence on whether BE supplementation, alone or in combination with multicomponent exercise, represents a practical and scalable intervention to improve cardiovascular, functional, and cognitive health in adults aged 75 years and older.",[28,29,30,31],"Cardiovascular Health","Functional Health","Cognitive Function Decline","Physical Performance Decline in Older Adults",[33,34,35,36,37,38],"beetroot extract","dietary nitrate","cardiovascular health","functional health","quality of life","cognitive function","RECRUITING","2026-06-26",{"date":42,"type":43},"2026-06-30","ACTUAL",{"date":45,"type":43},"2026-03-24",{"date":47,"type":22},"2027-11",{"name":49,"class":50},"Fundacion Miguel Servet","OTHER",1,{"id":53,"slug":54,"hasResults":11,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":58,"eligibilityCriteria":59,"healthyVolunteers":11,"sex":18,"minAge":60,"maxAge":4,"enrollmentInfo":61,"targetDuration":4,"studyType":23,"phases":63,"briefSummary":64,"conditions":65,"keywords":71,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":51},"100633834","multicomponent-prehabilitation-in-older-adults-with-breast-cancer-100633834","NCT07531836","Multicomponent Prehabilitation in Older Adults With Breast Cancer","Effectiveness of a Multicomponent Prehabilitation Program Combined With Biomarker Characterization in Older Adults With Breast Cancer","PREHAB-BC65","Inclusion Criteria:\n\n* Age ≥65 years\n* Diagnosis of cancer requiring elective surgery with curative intent\n* Candidate for prehabilitation program before surgery\n* Ability to walk (with or without assistive devices)\n* Ability to provide informed consent\n\nExclusion Criteria:\n\n* Urgent or emergency surgery\n* Severe cognitive impairment precluding participation in the intervention\n* Severe functional dependency (e.g., bedridden patients)\n* Medical contraindication to physical exercise\n* Life expectancy \\\u003C3 months","65 Years",{"count":62,"type":22},90,[25],"Older adults with breast cancer frequently present with frailty, decreased functional reserve, and increased risk of postoperative complications. Prehabilitation programs have emerged as a promising strategy to improve physical function and clinical outcomes; however, evidence in geriatric oncology remains limited, particularly regarding the role of biological markers in predicting response to such interventions.\n\nThis study aims to evaluate the effectiveness of a multicomponent prehabilitation program in older adults with breast cancer, focusing on functional status, clinical outcomes, and quality of life. In addition, the study seeks to characterize biological markers associated with frailty and treatment response, with the goal of identifying potential predictors of benefit from prehabilitation.\n\nParticipants will undergo a structured prehabilitation intervention including physical exercise, nutritional optimization, and comprehensive geriatric assessment. Clinical, functional, and biomarker data will be collected longitudinally.\n\nThe results of this study may contribute to improving personalized care strategies in geriatric oncology and to identifying patients who are most likely to benefit from prehabilitation programs.",[66,67,68,69,70],"Breast Cancer","Frailty","Sarcopenia","Aging","Functional Decline",[72,73,74,75,76,77,78,79,80,81],"Prehabilitation","Geriatric Oncology","Comprehensive Geriatric Assessment","Exercise Intervention","Vivifrail","Older Adults","Biomarkers","Functional Status","Quality of Life","Randomized Controlled Trial","2026-04-13",{"date":84,"type":43},"2026-04-15",{"date":86,"type":43},"2024-12-04",{"date":88,"type":22},"2027-08",{"name":49,"class":50},{"id":91,"slug":92,"hasResults":11,"nctId":93,"briefTitle":94,"officialTitle":95,"acronym":96,"eligibilityCriteria":97,"healthyVolunteers":11,"sex":18,"minAge":4,"maxAge":4,"enrollmentInfo":98,"targetDuration":100,"studyType":101,"phases":4,"briefSummary":102,"conditions":103,"keywords":106,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":110,"lastUpdatePostDateStruct":111,"startDateStruct":113,"completionDateStruct":115,"leadSponsor":117,"locationsCount":51},"100625018","persistent-covid-19-registry-in-navarre-100625018","NCT07417176","Persistent COVID-19 Registry in Navarre.","Persistent COVID-19 Registry in Navarre. (Persicov-19)","PERSICOV-19","Inclusion Criteria:\n\n* History of confirmed SARS-CoV-2 infection\n* Presentation of symptoms that have persisted for more than 3 months after SARS-CoV-2 infection\n* The patient reports any of the symptoms listed in the clinical assessment questionnaire or checklist.\n\nExclusion Criteria:\n\n* The symptom(s) referred to already existed prior to acute SARS-CoV-2 infection.",{"count":99,"type":22},200,"3 Months","OBSERVATIONAL","The goal of this observational study is to deepen our understanding of long COVID by determining the prevalence of the main complications and medium- to long-term sequelae of COVID-19 in Navarre.\n\nSociodemographic variables such as age, sex, ethnicity, smoking history, and comorbidities will be collected, as well as clinical and disease management variables such as persistent COVID-19 symptoms at 3 months, all with the aim of characterizing patients with long COVID.\n\nAll patient data will be collected in a single visit.",[104,105],"Long COVID Symptoms","Long COVI",[107,108,109],"long covid 19","Long COVID syndrome","Long COVID Fatigue","2026-02-18",{"date":112,"type":43},"2026-02-20",{"date":114,"type":43},"2021-01-04",{"date":116,"type":22},"2026-03-31",{"name":49,"class":50},{"id":119,"slug":120,"hasResults":11,"nctId":121,"briefTitle":122,"officialTitle":123,"acronym":124,"eligibilityCriteria":125,"healthyVolunteers":11,"sex":18,"minAge":126,"maxAge":127,"enrollmentInfo":128,"targetDuration":4,"studyType":23,"phases":130,"briefSummary":131,"conditions":132,"keywords":134,"overallStatus":139,"whyStopped":4,"lastUpdateSubmitDate":140,"lastUpdatePostDateStruct":141,"startDateStruct":143,"completionDateStruct":145,"leadSponsor":147,"locationsCount":51},"100615304","diactive-1-scaled-up-personalized-mhealth-program-for-youth-with-type-1-diabetes-100615304","NCT07290868","Diactive-1: Scaled-up Personalized mHealth Program for Youth With Type 1 Diabetes","Scaling up Personalized mHealth-supported Resistance Training and Education for Children and Adolescents With Type 1 Diabetes: The Diactive-1 v2.0 Randomized Controlled Trial","Diactive-1v2","Inclusion Criteria:\n\n* Diagnosed with Type 1 Diabetes Mellitus (T1DM) for 6 months or longer (requiring \\>0.5 U\u002Fkg\u002Fday of insulin and having HbA1c \\>6%, i.e., not in the \"honeymoon phase\").\n* Receiving multiple daily injection (MDI) therapy or insulin pump therapy (CSII).\n* Signed informed consent authorizing legal participation in the research project (child\u002Fadolescent and parent(s)\u002Flegal guardian).\n* Availability to participate in the study using an m-Health application (Diactive-1) designed for the programming of muscle-bone strengthening physical exercise.\n* Understanding of Spanish.\n\nExclusion Criteria:\n\n* Comorbidities that limit the ability to engage in physical activity.\n* Lack of internet access when using the application, whether due to Wi-Fi, mobile data, or international roaming issues.\n* Absence of a mobile phone or tablet with an Android or iOS (Apple) operating system, or no family member willing to lend a device for each session using the application for study-related purposes.","10 Years","18 Years",{"count":129,"type":22},158,[25],"The Diactive-1 project aims to establish the Diactive-1 mobile application as a clinical tool for managing type 1 diabetes in children and adolescents in several hospitals from Spain. The successful implementation of the app in new healthcare centers nationwide represents a key step toward the development of a comprehensive and scalable program. This approach seeks not only to optimize current patient care but also to democratize access to an innovative, evidence-based intervention that supports daily diabetes management.\n\nIn this new phase, the project will integrate the application into routine clinical care for patients with type 1 diabetes through the use of a simple handgrip strength measurement. A dedicated web platform (www.diactive.es) is being developed to allow clinicians to enter basic patient data, including handgrip strength, sex, and email address. Based on this information, the system will automatically generate a personalized download link for the Diactive-1 app, accompanied by tailored guidance and an initial fitness level classification (low, medium, or high) according to European reference values.\n\nThis process will define each user's baseline fitness level and facilitate the use of Diactive-1 as an integrated and individualized disease management tool. The ultimate goal is to strengthen clinical decision-making, improve patient engagement, and extend the benefits of digital health to a broader pediatric population living with type 1 diabetes.",[133],"Type 1 Diabetes (T1D)",[135,136,137,138],"mHealth","Resistance training","Education","Handgrip strength","NOT_YET_RECRUITING","2025-12-17",{"date":142,"type":43},"2025-12-18",{"date":144,"type":22},"2026-01",{"date":146,"type":22},"2027-03",{"name":49,"class":50},{"id":149,"slug":150,"hasResults":11,"nctId":151,"briefTitle":152,"officialTitle":153,"acronym":154,"eligibilityCriteria":155,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":156,"targetDuration":4,"studyType":23,"phases":158,"briefSummary":159,"conditions":160,"keywords":164,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":169,"lastUpdatePostDateStruct":170,"startDateStruct":172,"completionDateStruct":174,"leadSponsor":176,"locationsCount":51},"100598146","impact-of-physical-exercise-on-hospitalized-older-adults-malnourished-or-at-risk-with-oral-nutritional-support-100598146","NCT07067697","Impact of Physical Exercise on Hospitalized Older Adults Malnourished or at Risk, With Oral Nutritional Support","The Effect of Physical Exercise on the Physical Function of Hospitalized Older Adults Malnourished or at Risk of Malnourishment With Oral Nutritional Supplementation","NUTPHYS","Inclusion Criteria:\n\n* Aged 75 years or above\n* Hospitalized in the Acute Unit of the Geriatrics Service at the University Hospital of Navarra\n* 4 days or more of expected hospitalization\n* Malnourished according to the GLIM criteria or at risk of malnourishment (MUST scale)\n* Barthel Index ≥ 60 points\n* Capable of tolerating oral intake\n* Able to walk (with or without assistance)\n* Able to understand instructions and communicate\n* Consent to participate in the study after being informed of its objectives and who sign the informed consent (the participant or their legal guardian in case of disability).\n\nExclusion Criteria:\n\n* Advanced major neurocognitive disorder (GDS 6 and 7)\n* Uncontrolled cardiac arrhythmia, acute pulmonary thromboembolism, acute myocardial infarction, or bone fractures within the last 3 months\n* Chronic kidney disease stage 4 or 5\n* Safe and effective swallowing only with pudding texture\n* Inability to participate in the physical exercise program due to physical limitations\n* Participate in another study that may interfere with data interpretation or have participated in another study in six months prior to their entry into the study.",{"count":157,"type":22},102,[25],"The aim of this research is to analyze whether nutritional intervention combined with a multicomponent physical training program based on strength, balance, and aerobic exercises can prevent disability caused during hospitalization in individuals aged 75 years or older admitted for medical conditions, thereby improving functional and cognitive capacity.\n\nTo achieve this objective, we will conduct a randomized clinical trial in which patients are randomly assigned to either the control group, which does not perform the physical training, or the intervention group, which participates in the multicomponent physical training program.",[161,77,162,163],"Hospitalized","Physical Exercise","Oral Nutritional Supplementation",[165,166,167,168],"hospital-acquired disability","older adults","physical exercise","oral nutritional supplementation","2025-09-23",{"date":171,"type":43},"2025-09-24",{"date":173,"type":43},"2025-07-14",{"date":175,"type":22},"2026-07",{"name":49,"class":50},{"id":178,"slug":179,"hasResults":11,"nctId":180,"briefTitle":181,"officialTitle":182,"acronym":183,"eligibilityCriteria":184,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":185,"targetDuration":4,"studyType":23,"phases":186,"briefSummary":187,"conditions":188,"keywords":191,"overallStatus":139,"whyStopped":4,"lastUpdateSubmitDate":195,"lastUpdatePostDateStruct":196,"startDateStruct":198,"completionDateStruct":200,"leadSponsor":202,"locationsCount":4},"100606956","effect-of-a-combined-exercise-and-anti-inflammatory-nutritional-intervention-in-frail-older-adults-100606956","NCT07182292","Effect of a Combined Exercise and Anti-Inflammatory Nutritional Intervention in Frail Older Adults","Effectiveness of Combined Therapeutic Exercise and Anti-Inflammatory Nutritional Supplementation in Frail, Malnourished Older Adults","AliFrail","Inclusion Criteria:\n\n* Patient aged ≥ 75 years.\n* Diagnosis of frailty according to Linda Fried's criteria.\n* Diagnosis of malnutrition according to GLIM (Global Leadership Initiative on Malnutrition) criteria.\n* Barthel Index score ≥ 60 points.\n* Absence of advanced chronic kidney disease (defined as glomerular filtration rate \\\u003C 25 mL\u002Fmin\u002F1.73m²).\n* Absence of terminal illness as defined by SECPAL (Spanish Society for Palliative Care) criteria.\n\nExclusion Criteria:\n\n* Presence of type 1 or type 2 diabetes mellitus with poor metabolic control (HbA1c \\> 8% or insulin-dependent).\n* Oropharyngeal dysphagia to liquids that prevents safe intake of oral supplementation.\n* Moderate-to-severe cognitive impairment, defined as a score ≥ 5 on the Global Deterioration Scale (GDS) of Reisberg.\n* Refusal to sign the informed consent by the patient, primary caregiver, or legal representative, or inability to obtain it.\n* Known allergy or intolerance to any component of the study supplements.\n* Institutionalized in a long-term care or residential facility.",{"count":129,"type":22},[25],"The goal of this clinical trial is to evaluate whether a combined intervention of therapeutic exercise and anti-inflammatory nutritional supplementation improves physical performance and reduces systemic inflammation in frail, malnourished older adults. The main questions it aims to answer are:\n\nDoes the addition of an anti-inflammatory nutritional supplement (Alisenoc™) to a multicomponent exercise program (Vivifrail) lead to greater improvements in physical performance compared to standard exercise and conventional nutritional support?\n\nDoes the combined intervention reduce levels of inflammatory biomarkers (e.g., IL-6, TNF-α, IL-8, GDF-15) in this population?\n\nAre there measurable changes in body composition (e.g., muscle mass, fat mass, bone health) following the intervention?\n\nDoes the intervention impact clinical outcomes such as hospital readmissions, functional independence, or mortality over the following 12 months?\n\nResearchers will compare two groups:\n\nOne group receiving the Vivifrail exercise program plus a daily dose of the anti-inflammatory nutritional supplement Alisenoc™.\n\nAnother group receiving the same Vivifrail program plus an isocaloric, protein-equivalent conventional supplement.\n\nParticipants will:\n\nBe aged 75 years or older and identified as frail and malnourished according to Fried and GLIM criteria.\n\nUndergo baseline evaluation including functional performance (SPPB), body composition via bioimpedance analysis, and blood sample collection for inflammatory biomarkers.\n\nBe randomly assigned to one of the two intervention groups.\n\nFollow a 12-week home-based multicomponent exercise program guided by educational materials and supervised remotely.\n\nConsume the assigned oral nutritional supplement daily for the same 12-week period.\n\nReturn for outcome assessments at 12 weeks, and again at 6 and 12 months for long-term follow-up.\n\nAll study procedures will take place at the Hospital Universitario de Navarra (HUN), Spain. Participants will be recruited from outpatient geriatrics and nutrition clinics and assessed at a dedicated research unit with nursing support. The intervention is designed to be feasible, scalable, and representative of real-world multidisciplinary care in older populations with high vulnerability.\n\nThe study aims to provide evidence for an integrative, personalized approach to reversing frailty through combined physical and nutritional strategies targeting the biological basis of inflammaging.",[189,190],"Frail Elderly Syndrome","Malnutrition Elderly",[192,193,194],"inflammaging","malnutrition","frailty","2025-09-11",{"date":197,"type":43},"2025-09-19",{"date":199,"type":22},"2025-10-01",{"date":201,"type":22},"2027-10-01",{"name":49,"class":50},{"id":204,"slug":205,"hasResults":11,"nctId":206,"briefTitle":207,"officialTitle":207,"acronym":208,"eligibilityCriteria":209,"healthyVolunteers":11,"sex":18,"minAge":127,"maxAge":4,"enrollmentInfo":210,"targetDuration":4,"studyType":23,"phases":212,"briefSummary":213,"conditions":214,"keywords":238,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":195,"lastUpdatePostDateStruct":239,"startDateStruct":241,"completionDateStruct":243,"leadSponsor":245,"locationsCount":51},"100585650","digital-transformation-of-continuity-of-care-for-peripherally-inserted-central-catheters-spadcare-experience-100585650","NCT06905119","Digital Transformation of Continuity of Care for Peripherally Inserted Central Catheters: SpadCare Experience","SpadCare","Inclusion Criteria:\n\n* Patients \\>18 years.\n* Sign the informed consent form.\n* Have a Smartphone and accept the use of the APP.\n* Patient with a PICC inserted by the Infusion and Vascular Access Team of the University Hospital of Navarra and with a planned use of at least one month.\n\nExclusion Criteria:\n\n* Patients with limitations in the use of digital resources or lack of Smartphone.\n* Patients who do not want to install the APP on their Smartphone\n* Patients who do not authorize access to their Computerized Medical Record (HCI).",{"count":211,"type":22},201,[25],"The study focuses on patients who require outpatient infusion of therapy (\"Infusions, Intravenous\"\\[Mesh\\]) \"Administration, Intravenous\"\\[Mesh\\] (\"Home Infusion Therapy\"\\[Mesh\\]) \"Parenteral Nutrition, Home\"\\[Mesh\\] via a peripherally inserted central catheter (PICC) (\"Central Venous Catheters\"\\[MeSH\\] \"Catheterization, Central Venous\"\\[MeSH\\] \"Catheterization, Peripheral\" \\[MeSH\\] \"Vascular Access Devices\"\\[Mesh\\] )",[215,216,217,218,219,220,221,222,223,224,225,226,227,228,229,230,231,232,233,234,235,236,237],"Infusions, Intravenous","Administration, Intravenous","Home Infusion Therapy","Parenteral Nutrition, Home","Central Venous Catheters","Catheterization, Central Venous","Catheterization, Peripheral","Vascular Access Devices","Patient Education as Topic","Patient Participation","User-Computer Interface","Smartphone","Mobile Applications","Computers, Handheld","Digital Health","Nursing","Care Givers","Delivery of Health Care","Home Nursing","Self Administration","Adverse Effects","Catheter-Related Infections","Telemedicine",[221,222,223,237,227],{"date":240,"type":43},"2025-09-12",{"date":242,"type":43},"2023-05-04",{"date":244,"type":22},"2026-07-31",{"name":49,"class":50},{"id":247,"slug":248,"hasResults":11,"nctId":249,"briefTitle":250,"officialTitle":251,"acronym":252,"eligibilityCriteria":253,"healthyVolunteers":11,"sex":254,"minAge":127,"maxAge":4,"enrollmentInfo":255,"targetDuration":4,"studyType":23,"phases":257,"briefSummary":258,"conditions":259,"keywords":261,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":264,"lastUpdatePostDateStruct":265,"startDateStruct":267,"completionDateStruct":269,"leadSponsor":271,"locationsCount":272},"100598147","the-use-of-combined-motor-imagery-and-action-observation-to-evaluate-the-influence-on-functional-parameters-such-as-strength-range-of-motion-pain-or-fear-of-movement-among-others-in-females-breast-cancer-survivors-100598147","NCT07067710","The Use of Combined Motor Imagery and Action Observation to Evaluate the Influence on Functional Parameters Such as Strength, Range of Motion, Pain or Fear of Movement Among Others, in Females Breast Cancer Survivors.","Effectiveness of Combined Motor Imagery and Action Observation in Improving Pain, Range of Motion, and Upper Limb Lymphedema in Breast Cancer Survivors. Efectividad de Las Terapias de imaginería Motora y observación de la acción en la Mejora Del Dolor, la Movilidad y el Linfedema de la Extremidad Superior en Supervivientes de cáncer de Mama.","IM-OA23","Inclusion Criteria:\n\n* Female, over 18 years, have suffered breast cancer, have ended active treatments (chemotherapy, radiotherapy, surgery), have pain or functional limitation or lymphedema at upper limb afected.\n\nExclusion Criteria:\n\n* males, people with active treatments ongoning, other types of cancer, recurrence or metastasis of cancer","FEMALE",{"count":256,"type":22},108,[25],"The aim of this study is to evaluate the effectivity of the combined motor imagery and action observation therapies to improve functional parameters such as strenght, range of motion, pain or fear of movements among others in relation to upper limb in breast cancer survivors. The main question it aims to answer is: Will a combined therapy of motor imagery and action observation improve the strenght, rang of motion, pain, limb diameter and fear of movement of the upper limb in breast cancer survivor females? The participants will be part of the IM-OA23 proyect that consist on seeing some diferent videos about upper limb mobility and then they'll have to imagine the movements and to performed themselves. Researches will compare two groups (control group and intervention group) to evaluate the diferences between them.",[260],"Breast Cancer Survivor",[262,263],"Motor imagery","Action observation","2025-07-15",{"date":266,"type":43},"2025-07-16",{"date":268,"type":43},"2025-02-25",{"date":270,"type":22},"2026-02",{"name":49,"class":50},3,{"id":274,"slug":275,"hasResults":11,"nctId":276,"briefTitle":277,"officialTitle":278,"acronym":279,"eligibilityCriteria":280,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":281,"targetDuration":4,"studyType":23,"phases":283,"briefSummary":284,"conditions":285,"keywords":287,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":264,"lastUpdatePostDateStruct":292,"startDateStruct":294,"completionDateStruct":296,"leadSponsor":298,"locationsCount":299},"100564820","prevention-of-functional-and-cognitive-impairment-through-a-multicomponent-exercise-program-in-hospitalized-older-adults-100564820","NCT06634147","Prevention of Functional and Cognitive Impairment Through a Multicomponent Exercise Program in Hospitalized Older Adults","Prevention of Functional and Cognitive Impairment Through a Multicomponent Exercise Program in Hospitalized Older Adults (Geriatrics and Internal Medicine): a Randomized Clinical Trial. Multicenter Study (HUN, CHU-T, ULSBM, and HNSM)","PREDISC","Inclusion Criteria:\n\n* Age equal to or greater than 75 years, admitted to the acute care unit for medical conditions.\n\nExclusion Criteria:\n\n* Explicit refusal expressed verbally or refusal to sign the informed consent by the patient\u002Fmain caregiver\u002Flegal guardian or inability to obtain it.\n* Life expectancy of less than 3 months or terminal oncological or non-oncological disease.\n* Inability to follow up.\n* Inability to participate in a multicomponent exercise program.\n* Medical contraindication to exercise.\n* Major neurocognitive disorder at moderate to severe stage (GDS - Fast Reisberg 5-7).\n* Moderate to severe disability (measured by the Barthel Index (BI \\<60)).\n* Expected hospital stay of less than 6 days.",{"count":282,"type":22},296,[25],"The goal of this clinical trial is to determine whether a multicomponent exercise program improves functional capacity and cognitive status in hospitalized elderly patients aged 75 and older. Additionally, the study aims to assess the impact of this program on medication use, quality of life, and overall health outcomes. Key questions include whether the program enhances functional and cognitive capacities and which subgroups benefit most, such as frail patients or those with cognitive impairment.\n\nParticipants will engage in a structured exercise program that includes strength training, balance exercises, and walking, all designed to improve mobility and reduce fall risk. They will attend supervised sessions several times a week, allowing for individualized attention and adjustments based on their abilities and health status.\n\nThroughout the study, changes in functional capacity will be monitored using standardized assessments that measure mobility, strength, and overall physical functioning. Cognitive assessments will evaluate any changes in cognitive status during the intervention and follow-up periods post-discharge. Participants will provide information on medication usage to analyze whether the exercise program can reduce the need for medications or help manage common polypharmacy issues.\n\nSurveys and interviews will assess participants' quality of life, including physical, emotional, and social well-being, before and after the intervention. Follow-up assessments will track progress and outcomes, ensuring long-term benefits of the exercise program are documented.\n\nThe study will include a diverse sample from multiple centers, focusing on individuals aged over 75 who are hospitalized in Geriatrics and Internal Medicine services across participating centers (HUN, CHU-T, ULSBM, and HNSM). Exclusion criteria will ensure safety, excluding those with terminal illnesses or significant contraindications for exercise.\n\nThis clinical trial aims to recruit 296 patients, providing valuable insights into the benefits of physical activity for elderly patients during hospitalization and informing future care practices.",[286],"Clinical Deterioration",[288,289,290,291],"hospital acquired disability","exercise","function","cognition",{"date":293,"type":43},"2025-07-18",{"date":295,"type":43},"2025-02-01",{"date":297,"type":22},"2026-12-01",{"name":49,"class":50},2,{"id":301,"slug":302,"hasResults":11,"nctId":303,"briefTitle":304,"officialTitle":304,"acronym":305,"eligibilityCriteria":306,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":307,"targetDuration":4,"studyType":23,"phases":308,"briefSummary":309,"conditions":310,"keywords":314,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":319,"lastUpdatePostDateStruct":320,"startDateStruct":322,"completionDateStruct":324,"leadSponsor":325,"locationsCount":51},"100568141","impact-of-creatine-monohydrate-micronized-supplementation-with-or-without-multicomponent-training-in-older-adults-100568141","NCT06677359","Impact of Creatine Monohydrate Micronized Supplementation With or Without Multicomponent Training in Older Adults.","CREAGED","Inclusion Criteria:\n\n* Age: 75 years or older.\n* Able to ambulate with or without personal\u002Ftechnical assistance.\n* Life expectancy ≥ 6 months.\n* Barthel Index \\> 60.\n* Informed consent by patients, or legal representatives.\n\nExclusion Criteria:\n\n* Global Deterioration Scale (GDS 6-7).\n* Intolerance or allergy foods or drugs.\n* Deglutition problems (Dx: dysphagia)\n* Any pathological or metabolic condition incompatible with physical exercise.\n* Creatine supplementation for less than 6 weeks.\n* Consumption of more than 200 mg of caffeine daily.\n* Supervised physical training.",{"count":21,"type":22},[25],"The goal of this clinical trial is to study and evaluate whether a protocol of creatine supplementation, with or without multicomponent training, improves functional and cognitive capacity in individuals over 75 years old. The results of this study will further our understanding of creatine supplementation effects in the context of older patients and in combination with multicomponent training, thereby enhancing patient care strategies. Additionally, the goal is to improve the quality of life for the elderly and the efficiency of the healthcare system.\n\nThe main questions it aims to answer are:\n\n1. Does creatine supplementation alone provide physical, functional and cognitive benefits to people over 75 years of age?\n2. Is creatine supplementation safe for people over 75 years old?\n\nResearchers will compare creatine monohydrate supplementation with or without multicomponent training intervention to placebo supplementation with or without multicomponent training intervention to see if the creatine supplementation protocol leads to significant improvements in functional and cognitive outcomes. This comparison will help determine the effectiveness of the supplementation intervention in enhancing the overall well-being of elderly patients.\n\nParticipants will:\n\n* Engage in a structured multicomponent exercise program designed specifically for elderly patients. This program will include activities focused on strength training, balance exercises, and walking to improve mobility and reduce the risk of falls.\n* Attend supervised exercise sessions several times a week, allowing for individualized attention and adjustments based on each participants abilities and health status.\n* Be monitored for changes in functional capacity using standardized assessments, which will measure improvements in mobility, strength, and overall physical functioning.\n* Undergo cognitive assessments to evaluate any changes in cognitive status throughout the intervention and during follow-up periods after discharge.\n* Participate in surveys and interviews to assess their quality of life, including physical, emotional, and social well-being, before and after the intervention.\n* Attend follow-up assessments at designated intervals to track their progress and outcomes, ensuring that any long-term benefits of the exercise program are recognized and documented.\n\nInclusion criteria will focus on individuals aged over 75 years. Participants must be capable of communication and ambulation, either independently or with assistance.\n\n* Life expectancy ≥ 6 months.\n* Barthel Index \\> 60.\n\nExclusion criteria will ensure the safety and appropriateness of the intervention. Individuals who explicitly refuse to participate or cannot provide informed consent will be excluded. Additionally, those with a life expectancy of less than three months, terminal illnesses, or significant medical contraindications for exercise will not be eligible. Participants with moderate to severe neurocognitive disorders or disabilities that severely limit mobility will also be excluded to maintain the integrity of the intervention.\n\nThis clinical trial aims to recruit a total of 120 participants from the Geriatric Department or Primary Care, providing a comprehensive dataset to analyze the effectiveness and safety of the multicomponent exercise program. By examining the outcomes related to functional capacity, cognitive status, and quality of life, the study seeks to provide valuable insights into the benefits of physical activity for elderly patients during hospitalization.",[311,312,313],"Functionality","Cognition","Strength Training Effects",[315,316,317,318],"creatine","supplementation","multicomponent training","older people","2025-06-09",{"date":321,"type":43},"2025-06-12",{"date":323,"type":43},"2024-11-30",{"date":297,"type":22},{"name":49,"class":50},{"id":327,"slug":328,"hasResults":11,"nctId":329,"briefTitle":330,"officialTitle":331,"acronym":332,"eligibilityCriteria":333,"healthyVolunteers":11,"sex":18,"minAge":127,"maxAge":4,"enrollmentInfo":334,"targetDuration":4,"studyType":23,"phases":336,"briefSummary":337,"conditions":338,"keywords":346,"overallStatus":139,"whyStopped":4,"lastUpdateSubmitDate":355,"lastUpdatePostDateStruct":356,"startDateStruct":358,"completionDateStruct":359,"leadSponsor":361,"locationsCount":4},"100588663","reduction-of-complications-associated-with-picc-management-100588663","NCT06944327","Reduction of Complications Associated With PICC Management","Reduction of Complications Associated With PICC Management. Randomization in Care.","PICC managemen","Inclusion Criteria:\n\n* be over 18 years of age\n* accept participation in the study\n* independent patient in the care and management of activities of daily living\n\nExclusion Criteria:\n\n* patient over 18 years of age\n* patient with functional or cognitive limitation\n* patient with mild, moderate or high level of dependence\n* patient does not accept to perform the study\n* patient with device withdrawal prior to 14 days of duration",{"count":335,"type":22},460,[25],"The present study aims to analyze different care routes of the peripheral access central venous catheter to assess which alternative allows a moderate reduction in the level of complications associated with prolonged care frequency, due to the reduction of device manipulation.\n\nA high level of patient satisfaction is detected due to the controlled follow-up of the device care, as well as a decrease in the need for transfer to a center for follow-up.\n\nObjective: Identify the type of care frequency for PIVCs most beneficial for the reduction of complications associated with extraluminal device care (thrombosis, phlebitis, accidental removal, obstruction).",[339,340,341,342,343,344,345],"Treatment Outcome","Vascular Access","Vascular Access Device","Vascular Access Complication","Care Delivery","Nurse","Nurse Based Care Management",[347,348,349,350,351,352,353,354],"vascular","vascular access","catheter","central catheter","nurse","vascular access device","management","complication","2025-04-23",{"date":357,"type":43},"2025-04-25",{"date":199,"type":22},{"date":360,"type":22},"2027-12-31",{"name":49,"class":50},{"id":363,"slug":364,"hasResults":11,"nctId":365,"briefTitle":366,"officialTitle":367,"acronym":368,"eligibilityCriteria":369,"healthyVolunteers":11,"sex":18,"minAge":370,"maxAge":4,"enrollmentInfo":371,"targetDuration":4,"studyType":23,"phases":373,"briefSummary":374,"conditions":375,"keywords":381,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":388,"lastUpdatePostDateStruct":389,"startDateStruct":391,"completionDateStruct":393,"leadSponsor":395,"locationsCount":51},"100588234","novel-medical-device-for-pharmacological-therapy-100588234","NCT06938750","Novel Medical Device for Pharmacological Therapy","A Pilot Study of a Novel Medical Device for Pharmacological Therapy: The SecHold Device","Sechold","Inclusion Criteria:\n\n* patients admitted to the intensive care unit\n* patients with authorization to take part in the study\n\nExclusion Criteria:\n\n* Patients with pre-existing medical conditions: Patients with diseases affecting coagulation, such as hemophilia or thrombocytopathies, could be excluded.\n* Active infection patients: Any patient with vascular access site infections or systemic infections may be excluded to avoid complications.\n* Inability to give informed consent: Patients who are unable to understand or consent to participate in the study.","1 Year",{"count":372,"type":22},262,[25],"Background: Different co-creation methods were used to design and prototype a new fixative device for multiple intravenous therapies with the ability to control and identify the pharmacological therapy administered to a patient. Objectives: To validate a newly created device for the reduction of complications related to the use of intravenous therapy Methods: A multidisciplinary team composed of eight professionals specializing in the field of critical care and an engineering professional in industrial design was responsible for collecting, evaluating, and materializing the ideas and needs arising from clinical practice in a device that met the standards of the same.",[340,342,376,377,378,379,344,345,380],"Vascular Access Complications","Catheter Malfunction","Catheter Infection","Therapeutic Drug Management","Innovative Procedures",[382,383,384,385,386,387],"VASCULAR ACCESS","CATHETER","THERAPY","COMPLICATION","DEVICE","CENTRAL VASCULAR ACCESS","2025-04-14",{"date":390,"type":43},"2025-04-22",{"date":392,"type":43},"2023-01-20",{"date":394,"type":22},"2026-09-20",{"name":49,"class":50},{"id":397,"slug":398,"hasResults":11,"nctId":399,"briefTitle":400,"officialTitle":401,"acronym":402,"eligibilityCriteria":403,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":404,"targetDuration":4,"studyType":23,"phases":406,"briefSummary":407,"conditions":408,"keywords":410,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":416,"lastUpdatePostDateStruct":417,"startDateStruct":419,"completionDateStruct":421,"leadSponsor":423,"locationsCount":51},"100542239","immersive-virtual-reality-and-physical-exercise-on-cognitive-and-functional-performance-in-hospitalized-older-patients-100542239","NCT06340282","Immersive Virtual Reality and Physical Exercise on Cognitive and Functional Performance in Hospitalized Older Patients","Effects of Immersive Virtual Reality and\u002For Multicomponent Physical Exercise on Cognitive and Functional Performance in Hospitalized Older Patients With Severe Functional Dependency: Study Protocol for a Randomized Clinical Trial","MOTOMED","Inclusion Criteria:\n\nAge ≥ 75 years Clinica Stability Expected length of stay ≥ 5 days Being able to communicate and collaborate with the research team\n\nExclusion Criteria:\n\nBarthel Index score ≥ 60 at admission Refusal to sign the informed consent by the patient\u002Flegal guardian or inability to obtain it Life expectancy less than three months End-stage disease Severe level of major neurocognitive disorder (GDS 7)",{"count":405,"type":22},212,[25],"This study will be conducted in a hospital in Spain to investigate how a special intervention using immersive virtual reality technology can benefit hospitalized older adults with difficulties in their daily functionality.\n\nThe main objective of this study is to evaluate whether a cognitive stimulation intervention through immersive virtual reality, along with specific physical exercises, can improve the cognitive and physical function of hospitalized older patients. It is expected that this innovative intervention will have a positive impact on the quality of life of these patients.\n\nParticipants eligible for the study must be over 75 years old, have severe functional dependency upon hospital admission, and be willing to participate. Those with severe dementia or other terminal illnesses will be excluded.\n\nParticipants will be randomly assigned to one of four study groups: a control group without intervention and three intervention groups, including viewing Spanish landscapes through virtual reality, performing specific physical exercises, or a combination of both interventions.\n\nAt the end of the study, various aspects such as cognitive and physical function, mood, quality of life, muscle strength, and acceptance of virtual reality technology by patients will be evaluated.\n\nThis study aims to provide new insights into the care of hospitalized older adults and explore innovative ways to improve their well-being during their hospital stay",[409,312],"Disability Physical",[411,412,413,414,415],"hospital-associated functional decline","cognitive stimulation","immersive virtual reality","multicomponent physical exercise","disability","2025-01-10",{"date":418,"type":43},"2025-01-13",{"date":420,"type":43},"2024-04-01",{"date":422,"type":22},"2025-04-01",{"name":49,"class":50},{"id":425,"slug":426,"hasResults":11,"nctId":427,"briefTitle":428,"officialTitle":429,"acronym":4,"eligibilityCriteria":430,"healthyVolunteers":11,"sex":254,"minAge":127,"maxAge":4,"enrollmentInfo":431,"targetDuration":4,"studyType":23,"phases":432,"briefSummary":433,"conditions":434,"keywords":436,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":442,"lastUpdatePostDateStruct":443,"startDateStruct":445,"completionDateStruct":447,"leadSponsor":449,"locationsCount":51},"100503840","effect-of-strength-resistance-exercise-in-the-reduction-of-gestational-diabetes-in-pregnant-women-with-overweight-or-obesity-100503840","NCT05840497","Effect of Strength-resistance Exercise in the Reduction of Gestational Diabetes in Pregnant Women with Overweight or Obesity","Efecto Del Ejercicio De Fuerza-resistencia En La Disminución De La Diabetes Gestacional En Gestantes Con Sobrepeso U Obesidad","Inclusion Criteria:\n\n* BMI≥25 kg\u002Fm2\n* Singleton pregnancies\n\nExclusion Criteria:\n\n* Chronic hypertension\n* Pre-pregnancy DM (type I or 2 diabetes mellitus)\n* Cardiovascular disease\n* History of preterm delivery",{"count":99,"type":22},[25],"The aim of this trial is to test the efficacy of regular resistance exercise in early pregnancy to prevent gestational diabetes mellitus in overweight\u002F obese pregnant women.",[435],"Diabetes, Gestational",[437,438,439,440,441],"Exercise","Weight gain","Pregnant","Obese","Overweight","2024-11-20",{"date":444,"type":43},"2024-11-22",{"date":446,"type":43},"2023-03-01",{"date":448,"type":22},"2025-09-30",{"name":49,"class":50},{"id":451,"slug":452,"hasResults":11,"nctId":453,"briefTitle":454,"officialTitle":455,"acronym":456,"eligibilityCriteria":457,"healthyVolunteers":11,"sex":18,"minAge":4,"maxAge":4,"enrollmentInfo":458,"targetDuration":4,"studyType":23,"phases":460,"briefSummary":461,"conditions":462,"keywords":464,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":468,"lastUpdatePostDateStruct":469,"startDateStruct":471,"completionDateStruct":473,"leadSponsor":475,"locationsCount":51},"100493255","endosonography-guided-gallbladder-drainage-vs-non-endoscopic-treatment-in-inoperable-acute-cholecystitis-100493255","NCT05702775","Endosonography-guided Gallbladder Drainage vs Non-endoscopic Treatment in Inoperable Acute Cholecystitis","Endosonography-guided Gallbladder Drainage vs Non-endoscopic Treatment in Patients With Inoperable Acute Cholecystitis: a Multicenter Randomized Clinical Trial (EUS-DRAIN)","EUS-DRAIN","Inclusion Criteria:\n\n* Patient older than 18 years.\n* Definitive diagnosis of acute lithiasic cholecystitis according to the GP Tokyo 2018 criteria.\n* Surgical decision of inoperable patient (if one or more of the following criteria is met: age ≥80 years, American Society of Anesthesiology (ASA) III or more, Charlson Comorbidity Index \\> 5 and\u002For Karnofsky \\\u003C 50 or decision of the patient not to have surgery.\n* Signature of the informed consent of the study\n\nExclusion Criteria:\n\n* Operable acute cholecystitis.\n* Refusal of the patient to participate in the study.\n* Anatomy of the GI tract altered by previous hepatobiliary or upper GI surgery.\n* Ascites.\n* Inability to tolerate endoscopy sedation, perforation of the digestive tract, or other contraindication to endoscopy.\n* Patients with decompensated cirrhosis, portal hypertension and\u002For gastric varices\n* Coagulopathy with uncorrectable INR\\>1.5 or thrombocytopenia \\\u003C50,000\u002Fmm3 uncorrectable.\n* Other diagnoses on admission (choledocholithiasis, liver abscesses, acute pancreatitis or biliopancreatic neoplasia).\n* Hemodynamic instability.\n* Baseline ECOG \\>=4\n* Survival expectancy \\\u003C 6 months",{"count":459,"type":22},100,[25],"In this project the investigators propose to carry out a clinical trial that compares non-endoscopic treatment of cholecystitis with antibiotics versus endoscopic drainage in non-operable acute cholecystitism (AC), especially focused on the rate of subsequent EBP and recurrence of AC, as well as the impact on the quality of life, also exploring the costs.\n\nThe ultimate goal of this project is to generate knowledge and scientific evidence that makes it easier for health professionals to choose the most appropriate strategy for non-operable patients with lithiasic AC.\n\nOurworking hypothesis is that endoscopic treatment (EUS-GBD) will significantly reduce the number of EBP compared to non-endoscopic treatment in patients with non-operable lithiasic AC.",[463],"Cholecystitis, Acute",[465,466,467],"Cholecystitis","Non-operable","Endoscopic","2023-01-18",{"date":470,"type":43},"2023-01-27",{"date":472,"type":43},"2022-10-01",{"date":474,"type":22},"2026-07-01",{"name":49,"class":50},{"id":477,"slug":478,"hasResults":11,"nctId":479,"briefTitle":480,"officialTitle":481,"acronym":482,"eligibilityCriteria":483,"healthyVolunteers":11,"sex":18,"minAge":484,"maxAge":485,"enrollmentInfo":486,"targetDuration":4,"studyType":101,"phases":4,"briefSummary":488,"conditions":489,"keywords":494,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":496,"lastUpdatePostDateStruct":497,"startDateStruct":499,"completionDateStruct":501,"leadSponsor":503,"locationsCount":51},"100405180","results-of-surgical-treatment-of-the-hepatobiliopancreatic-surgical-unit-100405180","NCT04556019","Results of Surgical Treatment of the Hepatobiliopancreatic Surgical Unit","Results of the Surgical Treatment of Patients From Hepatobiliopancreatic Surgical Unit at the Complejo Hospitalario de Navarra","HPB","Inclusion Criteria:\n\n* All patients operated by the HPB Surgical Unit in the last 10 years (retrospective)\n* All patients being operated by the HPB Surgical Unit from January 2019 onwards who provide inform consent (prospective).\n\nExclusion Criteria:\n\n* Patients not eligible for surgery\n* Patients not interested in taking part in the study","15 Years","90 Years",{"count":487,"type":22},1000,"The main aims of this study are:\n\n1. \\- to evaluate post-surgical morbidity and mortality outcomes, following the criteria and the definitions from Claven-Dindo and ISGPS international classifications, of the patients operated by the HPB Surgical Unit.\n2. \\- to evaluate survival and disease-free survival rates of the patients operated by the HPB Surgical Unit due to tumoral cause.",[490,491,492,493],"Pancreas Disease","Liver Diseases","Surgical Procedure, Unspecified","Bile Duct Diseases",[495],"Hepatobiliopancreatic surgery","2020-09-15",{"date":498,"type":43},"2020-09-21",{"date":500,"type":43},"2019-01-03",{"date":502,"type":22},"2029-01",{"name":49,"class":50},""]