[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Fuzhou University Affiliated Provincial Hospital\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":94},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,47,69],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":26,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100612084","high-strength-suture-vs-traditional-tension-band-for-patellar-fractures-100612084",false,"NCT07248982","High-Strength Suture vs. Traditional Tension Band for Patellar Fractures","Prospective Cohort Study of High-Strength Suture Modified Tension Band Technique for the Treatment of Patellar Fractures","Inclusion Criteria:\n\n* 1.Age 18-55 years. 2.Radiographically confirmed patellar fracture (AO\u002FOTA 34-C1 or 34-C2). 3.First-time patellar fracture surgery. 4.Time from injury to surgery ≤ 2 weeks. 5.Able to comply with follow-up and provide written informed consent. 6.Normal pre-injury knee function. 7.Able to tolerate surgery and agree to surgical treatment. 8.Intact cognitive function.\n\nExclusion Criteria:\n\n* 1.Age \\\u003C18 or \\>55 years. 2.Pathological fractures. 3.Prior patellar surgery or severe underlying patellofemoral disease. 4.Time from injury to surgery \\>2 weeks. 5.Concurrent active infection or severe medical conditions. 6.Severe neuropsychiatric disorders affecting follow-up compliance. 7.Postmenopausal women. 8.Inability to tolerate surgery or refusal of surgery. 9.Comorbid patellar dysplasia, rheumatoid arthritis, or other patellofemoral diseases.\n\n  10.Comorbid systemic or local infection at surgical site. 11.Comorbid severe lower limb or systemic injuries. 12.Pre-injury cognitive impairment, mental disorder, or independent walking disability.\n\n  13.Other conditions unsuitable for enrollment.","ALL","18 Years","55 Years",{"count":20,"type":21},50,"ESTIMATED","OBSERVATIONAL","This prospective cohort study aims to evaluate the clinical efficacy of high-strength suture modified tension band fixation in treating patellar fractures and compare it with traditional screw-cable tension band fixation. Adult patients (18-55 years) with AO\u002FOTA 34-C1 or 34-C2 patellar fractures will be enrolled and followed for 12 months. Primary outcomes include Lysholm knee function score, knee range of motion (ROM), and visual analog scale (VAS) pain score at 12 months post-surgery. Secondary outcomes include fracture healing time, radiographic alignment quality, complication rates, reoperation rates, implant removal rates, SF-36 health survey scores, and patient satisfaction. No additional biological samples will be collected; data will focus on clinical, radiographic, and follow-up information.",[25],"Patella Fracture",[27,28,29,30,31,32,33],"Patellar Fracture","Tension Band Fixation","High-Strength Suture","Knee Function","Lysholm Score","VAS Pain Score","Prospective Cohort","RECRUITING","2025-11-21",{"date":37,"type":38},"2025-11-25","ACTUAL",{"date":40,"type":38},"2024-02-01",{"date":42,"type":21},"2026-06-30",{"name":44,"class":45},"Fuzhou University Affiliated Provincial Hospital","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":51,"acronym":4,"eligibilityCriteria":52,"healthyVolunteers":53,"sex":16,"minAge":17,"maxAge":54,"enrollmentInfo":55,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":57,"conditions":58,"keywords":4,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":64,"completionDateStruct":66,"leadSponsor":68,"locationsCount":4},"100607603","research-on-early-diagnosis-and-risk-stratification-biomarkers-of-anti-tumor-drug-associated-interstitial-pneumonia-driven-by-multi-omics-integration-100607603","NCT07190703","Research on Early Diagnosis and Risk Stratification Biomarkers of Anti-Tumor Drug-Associated Interstitial Pneumonia Driven by Multi-Omics Integration","Inclusion Criteria:\n\n* Adults ≥18 years of age with the ability to independently provide written informed consent, fulfilling the criteria for either the oncology or control cohort, capable of undergoing baseline BALF and peripheral blood sampling at treatment commencement or time of diagnosis, and consenting to serial blood sampling at 2-4 weeks and 8-12 weeks following treatment initiation.\n\nExclusion Criteria:\n\n1. Active infection or established non-drug-related etiology of ILD (including but not limited to connective tissue disease-associated ILD, environmental or occupational exposure-induced ILD, active radiation pneumonitis)\n2. Prolonged pre-enrollment treatment with moderate-to-high dose systemic corticosteroids or immunosuppressive agents that would compromise baseline evaluation\n3. Absolute contraindications to bronchoscopic procedures or inability to comply with scheduled key follow-up assessments\n4. Severe decompensated comorbid conditions\n5. Pregnancy or lactation period.",true,"100 Years",{"count":56,"type":21},200,"This study aims to construct an early diagnostic biomarker panel and risk stratification model for anti-tumor drug-related ILD through integrative analysis of multi-omics data including genomics, transcriptomics, proteomics, and metabolomics. Using baseline and post-treatment longitudinal samples collected from a multi-center prospective cohort, we will apply machine learning to screen for stable and reproducible feature sets and evaluate their sensitivity, specificity, and clinical applicability in an independent validation cohort. The goal is to achieve early identification and stratified management of ILD, optimize treatment decisions, reduce the incidence of severe adverse events, and improve patient survival and quality of life.",[59],"Anti-Tumor Drug-Associated Interstitial Pneumonia","NOT_YET_RECRUITING","2025-09-17",{"date":63,"type":38},"2025-09-24",{"date":65,"type":21},"2025-09",{"date":67,"type":21},"2026-09",{"name":44,"class":45},{"id":70,"slug":71,"hasResults":11,"nctId":72,"briefTitle":73,"officialTitle":74,"acronym":75,"eligibilityCriteria":76,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":77,"enrollmentInfo":78,"targetDuration":4,"studyType":80,"phases":81,"briefSummary":83,"conditions":84,"keywords":4,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":4},"100591706","preoperative-rehabilitation-training-and-total-knee-arthroplasty-outcomes-100591706","NCT06983912","Preoperative Rehabilitation Training and Total Knee Arthroplasty Outcomes","The Effect of Preoperative Rehabilitation on Functional Recovery After Total Knee Arthroplasty: A Randomized Controlled Trial","PRTKAO","Inclusion Criteria:\n\n1. Clinical diagnosis is osteoarthritis and Scheduled for joint replacement surgery.\n2. Age ≥18 years old and ≤90 years old, with no gender restrictions.\n3. Patients voluntarily participate in the study and sign the informed consent form.\n\nExclusion Criteria:\n\n1. Severe cardiopulmonary insufficiency, unable to tolerate rehabilitation training.\n2. Neurological disorders leading to motor dysfunction.\n3. Mental illnesses that prevent cooperation with rehabilitation training.\n4. Severe joint deformities or muscle atrophy present before surgery, affecting the implementation of rehabilitation training.","90 Years",{"count":79,"type":21},500,"INTERVENTIONAL",[82],"NA","Joint replacement surgery is an effective treatment for severe joint diseases, but the postoperative recovery process is complex and lengthy. Preoperative rehabilitation training, as an important part of preoperative preparation, has been proven to significantly improve postoperative recovery outcomes. However, there is currently a lack of systematic research on the optimal protocols and duration of preoperative rehabilitation training and their specific impacts on postoperative recovery. This study aims to evaluate the effects of preoperative rehabilitation training on postoperative recovery after joint replacement through a randomized controlled trial, providing scientific evidence for clinical practice.",[85],"Osteoarthritis of Knee","2025-05-14",{"date":88,"type":38},"2025-05-21",{"date":90,"type":21},"2025-08-01",{"date":92,"type":21},"2028-08-31",{"name":44,"class":45},""]