[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"GGZ Noord-Holland-Noord\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":109},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,41,79],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":40},"100523907","the-efficacy-of-treatments-to-improve-self-esteem-100523907",false,"NCT06101810","The Efficacy of Treatments to Improve Self-esteem","Self-esteem in a General Psychiatric Population: Comparing Competitive Memory Training (COMET) and Cognitive Behavioral Therapy (CBT)","Inclusion Criteria:\n\n\\- A self-perceived low self-esteem established by both patient and caregiver by means of (consent to) referral for self-esteem treatment.\n\nExclusion Criteria:\n\n* severe suicidality for which hospitalization or other forms of crisis care is necessary,\n* acute psychosis,\n* current manic episode,\n* current alcohol or drug abuse,\n* insufficient knowledge of the Dutch language,\n* illiteracy\n* being unable to identify at least one positive aspect of oneself, which does not need to be felt as convincing for the participant. The latter is an excluding criterium formulated by the COMET protocol.","ALL","18 Years","65 Years",{"count":20,"type":21},70,"ESTIMATED","INTERVENTIONAL",[24],"NA","The goal of this study is to examine the effectivity of two self-esteem interventions (COMET (Korrelboom) and CBT (De Neef)) in a general psychiatric population.\n\nThe main questions it aims to answer are:\n\n* is there a difference between the two interventions in effectiveness on increasing self-esteem?\n* is there a difference between the two interventions in effect on levels of anxiety, depression and general mental health?\n* are found effects on levels of anxiety, depression and general mental health associated with changes in self-esteem?\n* is the ability to use imagination a moderator for outcomes in both conditions?\n\nParticipants are randomised over both conditions. At baseline (T0), end of treatment (T1) and follow-up at 6 months (T2) several outcome measures are conducted, such as RSES, DASS and MHC-SF.",[27],"Self Esteem","RECRUITING","2026-01-27",{"date":31,"type":32},"2026-01-29","ACTUAL",{"date":34,"type":32},"2023-11-01",{"date":36,"type":21},"2026-08-01",{"name":38,"class":39},"GGZ Noord-Holland-Noord","OTHER",1,{"id":42,"slug":43,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":47,"eligibilityCriteria":48,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":49,"enrollmentInfo":50,"targetDuration":4,"studyType":52,"phases":4,"briefSummary":53,"conditions":54,"keywords":62,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":4},"100573650","norclozapine-kinetics-and-side-effects-in-therapy-resistant-schizophrenia-and-the-optimal-sampling-time-for-therapeutic-drug-monitoring-100573650","NCT06749041","Nor)Clozapine Kinetics and Side Effects in Therapy Resistant Schizophrenia and the Optimal Sampling Time for Therapeutic Drug Monitoring","Clozapine OpTimal Timing for Optimal moNitoring and Side Effects","COTTONS","Inclusion Criteria:\n\n* Standard treatment of a stable, oral dose of clozapine for at least one week (at steady state).\n* Age between 18-70 years.\n* Registered time of intake as well as sampling time and dosage.\n* Registered smoking status (yes\u002Fno).\n* At least two samples in the elimination phase of clozapine with both clozapine and norclozapine measured.\n* Measurement of the white cell count at least every three months or more often.\n* Routine metabolic screening performed at moment of inclusion.\n* Subjects should be able to understand the study information and procedures and give informed consent or when incapacitated subjects are not reliably able to give informed consent their legal representatives should give informed consent under the condition that these subjects are willing to participate.\n\nExclusion Criteria:\n\n* Pregnancy.\n* Malignancy or treatment with immunosuppressive medication.\n* Samples where cessation, start or dose change of interacting co-medication (such as valproic acid, gemfibrozil, fluvoxamine, omeprazole and cyclic oral contraceptives \\[21 on, 7 days off\\]) or changes in use of tobacco containing products occurred within seven days prior to blood sampling (21, 28, 34, 35).\n* Acute inflammation, infection or samples shortly after intoxication. In case this information is unknown, it may be derived by large unexpected change in levels compared to previous or target levels.\n* Not sampled at Starlet (blood collection site) or sampled by dried blood spot\n* Unknown status of smoking (including vaping).\n* Unknown time of intake of clozapine.\n* Unknown time of blood sampling.\n* If informed consent is not obtained by the patient or by a legal representative in a mentally incapacitated patient, i.e. a legally incompetent adult.","70 Years",{"count":51,"type":21},60,"OBSERVATIONAL","The goal of this observational study is to better understand how clozapine treatment can be tailored as regards minimizing side effects and optimizing efficacy and monitoring. Firstly, how clozapine is broken down into norclozapine in the liver and how both clozapine and norclozapine affect side effects are examined. In order to investigate this metabolization process in the liver inflammation levels in the blood are assessed, which inhibit the conversion of clozapine into norclozapine. In addition, various factors related to physical health are assessed, such as blood sugar, cholesterol, weight, waist circumference, blood pressure and heart rate. The role of hormones is investigated, such as cortisol, a stress hormone that affects metabolism and stress levels. Amino acids are examined, which are building blocks of proteins, and specific parts of DNA that influence clozapine metabolism. In addition, investigation follows whether 12 hours after ingestion is a well-chosen time at which the amount of clozapine is measured in the blood in case of ingestion once a day and twice a day. Finally, specific side effects of clozapine are assessed - with special attention to stool - and the severity of the psychiatric symptoms in patients with therapy resistant schizophrenia spectrum disorders.",[55,56,57,58,59,60,61],"Cardiovascular Side Effects of Clozapine","Neutropenia Due to Clozapine","General Side Effects of Clozapine","Constipation Due to Clozapine","Symptoms of Schizophrenia","Optimal Blood Sampling Time for Clozapine in Patients Who Receive Clozapine Once and Twice Daily","Clozapine and Norclozapine Plasma Level Concentrations",[63,64,65,66,67,68,69],"cardiovascular side effects","neutropenia","general side effects of clozapine","constipation","symptoms of schizophrenia","optimal blood sampling time","clozapine and norclozapine plasma level concentrations","NOT_YET_RECRUITING","2024-12-24",{"date":73,"type":32},"2024-12-30",{"date":75,"type":21},"2024-12-23",{"date":77,"type":21},"2027-12-01",{"name":38,"class":39},{"id":80,"slug":81,"hasResults":11,"nctId":82,"briefTitle":83,"officialTitle":83,"acronym":4,"eligibilityCriteria":84,"healthyVolunteers":85,"sex":16,"minAge":86,"maxAge":17,"enrollmentInfo":87,"targetDuration":4,"studyType":22,"phases":89,"briefSummary":90,"conditions":91,"keywords":97,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":101,"lastUpdatePostDateStruct":102,"startDateStruct":104,"completionDateStruct":106,"leadSponsor":108,"locationsCount":40},"100563553","online-therapy-youth-equivalent-to-treatment-as-usual-100563553","NCT06617663","Online Therapy Youth, Equivalent to Treatment As Usual?","Inclusion Criteria:\n\n* Adolescents aged 12-18 years who would benefit from ACT or EMDR within the SGGZ, as determined by the screeners at registration or current primary practitioner.\n* Client is stable, i.e. there is no serious crisis (to be determined by screener cq primary practitioner)\n* Sufficient command of the Dutch language to complete the questionnaires.\n* Client does not participate in other (intervention) studies\n\nExclusion Criteria:\n\n* Clients who are crisis-prone or enter in crisis\n* Clients who are in forced care (wvggz)",true,"12 Years",{"count":88,"type":21},172,[24],"With growing waiting lists in specialized youth mental health care (sGGZ) and shortages of care staff, finding creative solutions to respond to this scarcity issue is important. Online treatment is an example of this, which, especially for young people growing up in a digital age, can be an appropriate and accessible alternative to treatment at a physical location. Online treatment via video calling among youth, while researched and proven effective in a blended form, has not yet been sufficiently researched as a complete replacement for treatment at a physical location. As a result, the potential added value of online treatment for the pressing scarcity issue in healthcare is not yet sufficiently clear.\n\nThis study therefore focuses on investigating the effectiveness of fully online treatment using two proven effective interventions: Eye Movement Desensitization and Reprocessing (EMDR) and Acceptance and Commitment Therapy (ACT) within the youth sGGZ. With the results of this research at GGZ-NHN, the investigators want to contribute to the development of guidelines and standards for the implementation of online treatments within Dutch youth mental health care.",[92,93,94,95,96],"Depression","Trauma","Compulsive Disorder","Anxiety","Unexplained Symptom, Medically",[98,99,100],"EMDR intervention","ACT internvention","youth 12.18","2024-09-26",{"date":103,"type":32},"2024-09-27",{"date":105,"type":32},"2024-07-01",{"date":107,"type":21},"2026-09-01",{"name":38,"class":39},""]