[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Gadjah Mada University\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":432},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,15,0,[8,47,79,104,133,158,189,217,241,266,292,327,353,383,407],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100621627","brief-culturally-adapted-behavioral-activation-therapy-for-adults-with-depression-in-indonesian-primary-care-a-type-2-hybrid-effectiveness-implementation-trial-100621627",false,"NCT07373080","Brief Culturally Adapted Behavioral Activation Therapy for Adults With Depression in Indonesian Primary Care: A Type-2 Hybrid Effectiveness-Implementation Trial","Hybrid Type-2 Effectiveness-Implementation Study of Brief Culturally Adapted Behavioral Activation Therapy Delivered by Primary Care Psychologists for Adults With Depression in Indonesian Primary Care Setting: A Study Protocol of Pragmatic Parallel Cluster Randomized Controlled Trial","Inclusion Criteria:\n\n* aged 18-65 years old\n* scored 10 or above on PHQ-9\n* provide informed consent\n\nExclusion Criteria:\n\n* having diagnosis of bipolar disorder, psychotic disorders, or substance use disorders","ALL","18 Years","65 Years",{"count":20,"type":21},96,"ESTIMATED","INTERVENTIONAL",[24],"NA","This is a type-2 hybrid effectiveness-implementation study of brief culturally adapted behavioral activation for adults with depression in primary care setting. This clinical trial has two parallel aims: 1) to understand if brief culturally adapted behavioral activation therapy delivered by psychologist in primary care in individual face-to-face session is effective to reduce depressive symptoms among adult patients in Primary Healthcare Centers and 2) to test the outcome of clinical training and supervision on acceptability, feasibility, appropriateness, and fidelity of implementation of brief culturally adapted behavioral activation therapy in Primary Healthcare Centers. The main questions it aims to answer is:\n\n1\\) Is brief culturally adapted behavioral activation intervention delivered by primary care psychologist effective in reducing depressive symptoms among adult patients with depression in primary care settings and 2) Are training and supervision effective in enhancing acceptability, feasibility, appropriateness and fidelity of implementation of brief culturally adapted behavioral activation therapy for adults with depression in primary care settings?",[27],"Depression in Adults",[29,30,31,32,33],"depression","behavioral activation therapy","culturally adapted treatment","implementation science","hybrid trial","RECRUITING","2026-05-28",{"date":37,"type":38},"2026-06-01","ACTUAL",{"date":40,"type":38},"2026-02-11",{"date":42,"type":21},"2026-07-31",{"name":44,"class":45},"Gadjah Mada University","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":54,"sex":16,"minAge":55,"maxAge":17,"enrollmentInfo":56,"targetDuration":4,"studyType":22,"phases":58,"briefSummary":59,"conditions":60,"keywords":65,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":46},"100629584","clinical-trial-of-lactiplantibacillus-plantarum-dad-13-on-gut-microbiota-profile-and-performance-in-adolescent-athletes-100629584","NCT07476573","Clinical Trial of Lactiplantibacillus Plantarum Dad-13 on Gut Microbiota Profile and Performance in Adolescent Athletes","Dad-13","Inclusion Criteria:\n\n* Residing in the BPPLOP dormitory of Central Java Province;\n* Having a normal body mass index;\n* Being an athlete in an endurance sport;\n* Having no growth disorders\n\nExclusion Criteria:\n\n* Injury, any health contraindication or failure to perform exercise procedures;\n* Gastrointestinal infections, diseases, disorders;\n* Past history of gastrointestinal surgery;\n* Failure to follow the study protocol;\n* Declared general feeling of being unwell",true,"12 Years",{"count":57,"type":21},30,[24],"The aim of this research is to analyze the effect of a Lactiplantibacillus plantarum Dad-13 supplementation on the gut microbiota profile and performance of adolescent athletes.",[61,62,63,64],"Athlete","Probiotic","Performance","Gut Microbiota",[66,67,68,69],"athlete","probiotic","performance","gut microbiota","NOT_YET_RECRUITING","2026-03-19",{"date":73,"type":38},"2026-03-23",{"date":75,"type":21},"2026-04-13",{"date":77,"type":21},"2026-08-30",{"name":44,"class":45},{"id":80,"slug":81,"hasResults":11,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":4,"eligibilityCriteria":85,"healthyVolunteers":54,"sex":16,"minAge":86,"maxAge":87,"enrollmentInfo":88,"targetDuration":4,"studyType":22,"phases":90,"briefSummary":91,"conditions":92,"keywords":4,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":46},"100608228","mobile-health-mhealth-application-for-smoking-cessation-among-adolescents-in-indonesia-100608228","NCT07198828","Mobile Health (mHealth) Application for Smoking Cessation Among Adolescents in Indonesia","Development and Evaluation of a Mobile Health (mHealth) Application for Smoking Cessation Among Adolescents in Indonesia: A Mixed Methods Randomized Controlled Trial","Inclusion Criteria:\n\n1. Phase 1 (Qualitative Study):\n\n   * Adolescent smokers aged 13-15 years\n   * Smoking at least one cigarette or vaping once per week\n   * Key informants: teachers, parents, peers, healthcare workers with relevant experience\n2. Phase 3 (RCT):\n\n   * Adolescents aged 13-15 years\n   * Smoking at least 1 cigarette in the past week\n   * Own smartphone with internet access\n   * Living in Padang City during study period\n   * Willing to participate until study completion\n   * Desire to quit smoking\n\nExclusion Criteria:\n\nPhase 3 (RCT):\n\n* Currently using other smoking cessation apps or programs\n* Planning to change schools or relocate outside Padang during study period\n* Have severe psychiatric or medical conditions requiring intensive treatment\n* Unable to use smartphone applications due to literacy or technical limitations","13 Years","15 Years",{"count":89,"type":21},110,[24],"This mixed-methods study develops and evaluates a mobile health (mHealth) application for smoking cessation among Indonesian adolescents aged 13-15 years. The study uses a sequential exploratory approach with three phases: (1) qualitative research to inform app design; (2) app development using Rapid Application Development (RAD) model; and (3) a single-blind, two-arm randomized controlled trial comparing the mHealth intervention to paper-based materials. The intervention is grounded in the Unified Theory of Acceptance and Use of Technology (UTAUT2) and Transtheoretical Model (TTM). Primary outcome is smoking abstinence at 1-, 3-, and 6-month follow-ups measured through self-report questionnaires.",[93,94,95],"Tobacco Use Disorder","Smoking Cessation","Adolescent Smoking","2026-02-02",{"date":98,"type":38},"2026-02-04",{"date":100,"type":21},"2026-03-01",{"date":102,"type":21},"2026-08-31",{"name":44,"class":45},{"id":105,"slug":106,"hasResults":11,"nctId":107,"briefTitle":108,"officialTitle":109,"acronym":4,"eligibilityCriteria":110,"healthyVolunteers":11,"sex":111,"minAge":4,"maxAge":4,"enrollmentInfo":112,"targetDuration":4,"studyType":22,"phases":114,"briefSummary":115,"conditions":116,"keywords":118,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":124,"lastUpdatePostDateStruct":125,"startDateStruct":127,"completionDateStruct":129,"leadSponsor":131,"locationsCount":132},"100619781","sensory-block-onset-epidural-vs-dural-puncture-epidural-in-cesarean-section-100619781","NCT07349082","Sensory Block Onset: Epidural vs Dural Puncture Epidural in Cesarean Section","Comparison of Sensory Block Onset Time Between Epidural and Dural Puncture Epidural (DPE) Anesthesia for Cesarean Delivery: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Pregnant women scheduled to undergo cesarean delivery\n* American Society of Anesthesiologists (ASA) physical status II-III\n* Willing to participate in the study by providing written informed consent\n\nExclusion Criteria:\n\n* Patients with absolute contraindications to neuraxial anesthesia\n* Patients with known allergy or history of allergy to medications used in the study\n* Patients with psychiatric disorders or who are uncooperative\n* Patients with accidental dural puncture\n\nDropout Criteria:\n\n* Patients who require conversion to general anesthesia during the procedure\n* Patients who experience major intraoperative complications (massive hemorrhage, shock, or cardiac arrest)","FEMALE",{"count":113,"type":21},72,[24],"The goal of this clinical trial is to compare the onset of sensory block between epidural anesthesia and dural puncture epidural (DPE) in patients undergoing elective cesarean delivery. The study also aims to evaluate hemodynamic stability and procedure-related side effects associated with both techniques.\n\nThe main questions it aims to answer are:\n\n1. What is the difference in the onset of sensory block between epidural anesthesia and dural puncture epidural (DPE) in patients undergoing cesarean section?\n2. Are there differences in hemodynamic stability between epidural anesthesia and DPE during surgery?\n3. What procedure-related side effects occur with each anesthetic technique?\n\nResearchers will compare epidural anesthesia with dural puncture epidural (DPE) to determine which technique achieves a faster and more effective sensory block while maintaining maternal hemodynamic stability.\n\nParticipants will:\n\n1. Be randomly assigned to receive either epidural anesthesia or DPE anesthesia\n2. Undergo elective cesarean delivery under regional anesthesia\n3. Have sensory block onset, hemodynamic parameters, and adverse events monitored and recorded intraoperatively",[117],"Cesarean Section",[119,120,121,122,123],"cesarean section","epidural anesthesia","dural puncture epidural","sensory block onset","hemodynamic stability","2026-01-15",{"date":126,"type":38},"2026-01-16",{"date":128,"type":21},"2026-01-05",{"date":130,"type":21},"2026-05-01",{"name":44,"class":45},2,{"id":134,"slug":135,"hasResults":11,"nctId":136,"briefTitle":137,"officialTitle":138,"acronym":4,"eligibilityCriteria":139,"healthyVolunteers":11,"sex":16,"minAge":140,"maxAge":17,"enrollmentInfo":141,"targetDuration":4,"studyType":22,"phases":143,"briefSummary":145,"conditions":146,"keywords":149,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":151,"lastUpdatePostDateStruct":152,"startDateStruct":154,"completionDateStruct":156,"leadSponsor":157,"locationsCount":46},"100617585","phase-4-levofloxacin-prophylaxis-to-prevent-first-febrile-neutropenia-in-pediatric-all-during-induction-phase-100617585","NCT07320534","Levofloxacin Prophylaxis to Prevent First Febrile Neutropenia in Pediatric ALL During Induction Phase","The Effect of Levofloxacin Prophylaxis on the First Occurrence of Febrile Neutropenia During Induction Chemotherapy in Pediatric Patients With Acute Lymphoblastic Leukemia at Dr. Sardjito Hospital","Inclusion Criteria:\n\n* All patients aged 1 to 18 years diagnosed with acute lymphoblastic leukemia (ALL).\n* Receiving induction phase 1A chemotherapy for ALL using the Indonesian National Childhood ALL Pilot Protocol 2024 Standard Risk; induction phases 1A and 1B chemotherapy using the Indonesian National Childhood ALL Pilot Protocol 2024 High Risk; or induction chemotherapy using the ACT4ALL Protocol 2025 at Dr. Sardjito Hospital.\n* No history of allergy to levofloxacin.\n* Parents\u002Fguardians provide written informed consent.\n\nExclusion Criteria:\n\n* Death before initiation of chemotherapy.\n* Patients with clinically or microbiologically confirmed infection within 72 hours prior to induction chemotherapy who require antibiotics for more than 5 days (to avoid antibiotic therapy as a confounding factor for antibiotic prophylaxis).","6 Months",{"count":142,"type":21},124,[144],"PHASE4","The goal of this clinical trial is To evaluate the benefit of levofloxacin prophylaxis in prolonging the median time to first febrile neutropenia in pediatric ALL patients during induction phase. It will also learn about the safety of levofloxacin during induction treatment.\n\nThe main questions it aims to answer are:\n\n* Does levofloxacin prophylaxis increase the median time to the first febrile neutropenia episode compared to placebo?\n* What are the rates of fever, severe infection, organ-related bacterial infection, and mortality in children receiving levofloxacin compared to placebo?\n\nResearchers will compare oral levofloxacin to a placebo (a look-alike substance with no active drug) to see if levofloxacin is effective in preventing infection during induction chemotherapy.\n\nParticipants will:\n\n* Be children aged 1 to 18 years with ALL undergoing induction chemotherapy.\n* Be randomly assigned to receive either levofloxacin prophylaxis or placebo during the induction phase.\n* Have regular checkups, physical exams, and laboratory tests during induction.\n* Be monitored for fever, febrile neutropenia, severe infections, bacterial infections, and mortality.\n* Stop prophylaxis once the first febrile neutropenia occurs or induction therapy is completed.",[147,148],"Neutropenic Fever","Acute Lymphoblastic Leukemia",[147,148,150],"Levofloxacin","2026-01-06",{"date":153,"type":38},"2026-01-08",{"date":155,"type":21},"2026-01-01",{"date":102,"type":21},{"name":44,"class":45},{"id":159,"slug":160,"hasResults":11,"nctId":161,"briefTitle":162,"officialTitle":163,"acronym":4,"eligibilityCriteria":164,"healthyVolunteers":54,"sex":111,"minAge":165,"maxAge":166,"enrollmentInfo":167,"targetDuration":4,"studyType":22,"phases":169,"briefSummary":170,"conditions":171,"keywords":175,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":180,"lastUpdatePostDateStruct":181,"startDateStruct":183,"completionDateStruct":185,"leadSponsor":187,"locationsCount":188},"100575308","breastfeeding-education-through-clinical-demonstration-for-primiparous-women-to-prevent-sore-nipples-and-engorgement-100575308","NCT06770595","Breastfeeding Education Through Clinical Demonstration for Primiparous Women to Prevent Sore Nipples and Engorgement","The Effect of Prenatal Breastfeeding Education Through Clinical Demonstrations for Primiparous Women to Prevent Sore Nipples and Engorgement","Inclusion Criteria:\n\n* Primigravida pregnant women who visited the Kasihan, Pajangan, Sewon, Banguntapan, Pleret, and Jetis health service centers\n* Single pregnancy\n* Mother has a mobile phone with internet access and can use WhatsApp Application\n* Plans to stay for 6 months in the research area\n* Willing to participate in the research by signing the informed consent\n\nExclusion Criteria:\n\n* Presence of congenital orofacial abnormalities (labio-gntao-palatoschisis, etc) that make breastfeeding difficult\n* Mother with breast problems (history of implant breast surgery)\n* The mother or baby experiences problems during labor or postpartum that may lead to research dropouts","19 Years","35 Years",{"count":168,"type":21},100,[24],"Several studies show that breastfeeding problems in the first days of birth pose a significant obstacle to successful breastfeeding. Among the most common breast problems experienced by mothers are breast abscesses, mastitis, nipple pain and sore nipples, engorgement, and flat or inverted nipples. Treatment for sore nipples and breast engorgement is mostly focused on medication. There is very little research that focuses on the impact of interventions regarding breastfeeding techniques carried out during the antenatal period to prevent sore nipples.\n\nKnowing the effect of breastfeeding position and attachment education through clinical demonstration in third-trimester primigravida pregnant women to prevent sore nipples and engorgement.\n\nThis research uses quasi-experiments. The population in this research is a third-trimester pregnant woman in the Kasihan, Pajangan, Sewon, Banguntapan, Pleret, and Jetis Community Health Centers. The number of samples in this study was 100 divided into 2, namely 50 intervention groups and 50 control groups. breastfeeding education will be provided to pregnant women at 34-35 weeks of gestation, as led by a lactation counselor. The first session will take place at a puskesmas (public health center), where mothers will receive an e-booklet, followed by 40 minutes of hands-on clinical skills training for those in the intervention group. A second session will take place two weeks after the first session in the form of a home visit only for those in the intervention group. The outcome of this research is position, attachment, effective sucking, nipple pain, sore nipples, and engorgement. T-test and chi-square will be used to test differences and similarities between study groups.",[172,173,174],"Nipple Infection","Nipple Discharge","Engorgement",[176,177,178,174,179],"Demonstration clinic","Education","Sore nipples","Breastfeeding","2025-12-14",{"date":182,"type":38},"2025-12-19",{"date":184,"type":21},"2025-12-26",{"date":186,"type":21},"2026-03-31",{"name":44,"class":45},6,{"id":190,"slug":191,"hasResults":11,"nctId":192,"briefTitle":193,"officialTitle":194,"acronym":4,"eligibilityCriteria":195,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":196,"targetDuration":4,"studyType":22,"phases":198,"briefSummary":199,"conditions":200,"keywords":203,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":209,"lastUpdatePostDateStruct":210,"startDateStruct":212,"completionDateStruct":214,"leadSponsor":216,"locationsCount":46},"100612620","accuracy-between-transthoracal-needle-aspiration-ttna-techniques-in-suspected-lung-cancer-patients-100612620","NCT07255950","Accuracy Between Transthoracal Needle Aspiration (TTNA) Techniques in Suspected Lung Cancer Patients","Accuracy Between Jabbing-then-suction, Suction-with-jabbing, and Suction-only Transthoracal Needle Aspiration (TTNA) Techniques in Suspected Lung Cancer Patients","Inclusion Criteria:\n\n* Patients with suspected lung cancer who will undergo diagnostic testing using ultrasound-guided TTNA of the lung with cell block and core biopsy.\n* Patients aged 18-75 years.\n* The tumor is located peripherally, attached to the chest wall.\n\nExclusion Criteria:\n\n* Patient refuses lung biopsy\n* Non-cooperative patient\n* Patient with respiratory failure, on positive pressure ventilation\n* Severe pulmonary emphysema\n* Contralateral pneumonectomy\n* Advanced pulmonary fibrosis\n* Platelet count \\\u003C100,000\u002Fmm3 and international normalized ratio (INR) \\>1.4",{"count":197,"type":21},54,[24],"* The objective of this research is to determine the accuracy of different types of lung transthoracal needle aspiration (TTNA) i.e. jabbing-then-suction, suction-with-jabbing, and suction-only TTNA in patients with suspected lung cancer.\n* Researchers will compare these techniques to determine whether there are any quality differences in the obtained tumor samples",[201,202],"Lung Cancer (Diagnosis)","Biopsy, Fine-Needle\u002FMethods",[204,205,206,207,208],"NSCLC","Non-small cell lung cancer","Transthoracal needle aspiration","Biopsy","Diagnostics","2025-11-27",{"date":211,"type":38},"2025-12-01",{"date":213,"type":38},"2025-07-15",{"date":215,"type":21},"2026-02",{"name":44,"class":45},{"id":218,"slug":219,"hasResults":11,"nctId":220,"briefTitle":221,"officialTitle":222,"acronym":4,"eligibilityCriteria":223,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":224,"targetDuration":4,"studyType":22,"phases":226,"briefSummary":227,"conditions":228,"keywords":229,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":234,"lastUpdatePostDateStruct":235,"startDateStruct":236,"completionDateStruct":238,"leadSponsor":240,"locationsCount":46},"100602237","pilot-study-of-brief-culturally-adapted-behavioral-activation-for-adults-with-depression-in-primary-care-setting-100602237","NCT07120893","Pilot Study of Brief Culturally Adapted Behavioral Activation for Adults With Depression in Primary Care Setting","Pilot Study Assessing Acceptability, Feasibility, and Appropriateness of Brief Culturally Adapted Behavioral Activation for Adults With Depression in Primary Care Setting","Inclusion Criteria:\n\n* scored 10 or above on PHQ-9\n* provide informed consent\n\nExclusion Criteria:\n\n* having diagnosed of bipolar disorder, psychotic disorders, or substance abuse disorders",{"count":225,"type":21},12,[24],"This is a pilot study of culturally adapted behavioral activation for adults with depression in primary care setting. As a pilot study following systematic cultural adaptation process, the purpose of this clinical trial is to understand if brief culturally adapted individual intervention based on behavioral activation, can be an acceptable, feasible, and appropriate intervention to reduce depressive symptoms among adults with depression in primary care setting. The main question it aims to answer is:\n\nIs brief culturally adapted behavioral activation intervention delivered by primary care psychologist acceptable, feasible, and appropriate as an evidence based treatment for reducing depressive symptoms among adults with depression in primary care setting?",[27],[230,231,232,233],"culturally adapted behavioral activation","depressive disorder","primary care","pilot study","2025-11-24",{"date":211,"type":38},{"date":237,"type":38},"2025-09-22",{"date":239,"type":21},"2025-12-13",{"name":44,"class":45},{"id":242,"slug":243,"hasResults":11,"nctId":244,"briefTitle":245,"officialTitle":246,"acronym":4,"eligibilityCriteria":247,"healthyVolunteers":54,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":248,"targetDuration":4,"studyType":22,"phases":250,"briefSummary":251,"conditions":252,"keywords":4,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":259,"lastUpdatePostDateStruct":260,"startDateStruct":262,"completionDateStruct":264,"leadSponsor":265,"locationsCount":46},"100606109","yoga-asana-chandra-harmoni-on-psychological-well-being-and-learning-readiness-among-medical-students-100606109","NCT07171268","Yoga Asana Chandra Harmoni on Psychological Well-being and Learning Readiness Among Medical Students","A Randomized Controlled Trial of Yoga Asana Chandra Harmoni on Psychological Well-being and Learning Readiness Among Medical Students","Inclusion Criteria:\n\n* 3rd-year medical student\n* Willing to attend yoga sessions and practice at home.\n* Willing to provide consent and complete assessments.\n\nExclusion Criteria:\n\n* Regular yoga practice (≥ 6 months).\n* Physical contraindications to yoga.\n* Active treatment for severe mental health disorder.\n* Concurrent participation in another intervention study.",{"count":249,"type":21},80,[24],"The goal of this trial is to learn if the Yoga Asana Chandra Harmoni intervention can improve psychological well-being and learning readiness in medical students. The main questions it aims to answer are:\n\nDoes Yoga Asana Chandra Harmoni improve psychological well-being (specifically, reduce stress, anxiety, and depression) in medical students? Does Yoga Asana Chandra Harmoni enhance self-directed learning readiness in medical students? Researchers will compare a group receiving the Yoga Asana Chandra Harmoni intervention to a control group to see if the intervention leads to significant improvements in psychological well-being and self-directed learning readiness.\n\nParticipants will:\n\nComplete baseline questionnaires assessing psychological well-being, sleep quality, self-directed learning readiness, and self-efficacy.\n\nParticipate in 3 weekly Yoga Asana Chandra Harmoni sessions for 4 weeks (intervention group).\n\nContinue with their usual activities (control group). Complete follow-up questionnaires at post-test (end of week 4) and at a 2-week follow-up to assess changes in the outcome measures.\n\nEngage in additional online audio guided practices 5 times\u002Fweek for 20-30 minutes, including breathing exercises (weeks 1-2) and body scans (weeks 3-4) (intervention group).",[253,254,255,256,257,258],"Yoga","Yoga Exercises","Well Being","Self Efficacy","Medical Student","Health and Wellness","2025-09-10",{"date":261,"type":38},"2025-09-12",{"date":263,"type":21},"2025-12-30",{"date":100,"type":21},{"name":44,"class":45},{"id":267,"slug":268,"hasResults":11,"nctId":269,"briefTitle":270,"officialTitle":271,"acronym":4,"eligibilityCriteria":272,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":17,"enrollmentInfo":273,"targetDuration":4,"studyType":22,"phases":275,"briefSummary":276,"conditions":277,"keywords":280,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":284,"lastUpdatePostDateStruct":285,"startDateStruct":287,"completionDateStruct":289,"leadSponsor":291,"locationsCount":46},"100594186","phase-4-ciprofloxacin-vs-ceftazidime-for-empirical-treatment-of-high-risk-neutropenic-fever-in-children-with-hematologic-malignancies-100594186","NCT07016165","Ciprofloxacin vs Ceftazidime for Empirical Treatment of High-Risk Neutropenic Fever in Children With Hematologic Malignancies","Ciprofloxacin Versus Ceftazidime as Empirical Therapy of High-Risk Neutropenic Fever in Children With Hematologic Malignancies : A Randomized Controlled Trial","Inclusion Criteria:\n\n* Children aged 0 to 18 years with hematological malignancies.\n* Children with high-risk neutropenic fever, namely children with blood malignancies induction phase ALL, consolidation phase ALL, reinduction phase ALL, relapse ALL; meningeal ALL, AML, and NHL, diagnosed by a competent pediatrician on duty.\n* Consent from parents to be included in the study.\n\nExclusion Criteria:\n\n* Children with malignancies but accompanied by comorbidities (HIV infection, septic shock).\n* Allergy to ciproloxacin or ceftazidime.\n* Fever associated with blood transfusion reactions.\n* Receiving other antibiotics since 72 hours before being included in the study, except for cotrimoxazole prophylaxis for the prevention of Pneumocystis carinii pneumonia, and ciproloxacin prophylaxis in AML.\n* Children with blood malignancies who have impaired renal function (serum creatinine ≥ 1.5 times the upper normal limit) and impaired liver function (SGPT \\> 5 times the upper normal limit).",{"count":274,"type":21},120,[144],"This clinical trial will compare use of ciprofloxacin and ceftazidime work in treating high-risk fever in children with hematological malignancies\n\n1. Does ceftazidime work better than ciprofloxacin as a first-choice antibiotic for children with hematological malignancies who have high-risk fever from low neutrophil count?\n2. Are there any specific factors that affect how children with hematological malignancies respond to ciprofloxacin or ceftazidime when treating high-risk fever?\n\nParticipants in this study are children with hematological malignancies who have a high risk of fever due to low neutrophil count. Children, aged 0 to 18 years old, will be hospitalized between June and December 2025 at Sardjito General Hospital\n\nThe study will involve:\n\n* Collecting patient history, conducting physical exams, and performing supporting tests.\n* Randomly assigning participants into two groups: one group will receive the standard treatment with intravenous ciprofloxacin, while the other group will receive the intervention treatment with intravenous ceftazidime.\n* Both groups will be monitored for various outcomes, including the length of fever, length of low white blood cell count, length of hospital stay, length of antibiotic use, any changes in antibiotics, and mortality.",[147,148,278,279],"Acute Myeloblastic Leukemia","Non Hodgkin Lymphoma",[281,282,283,148,278,279],"ciprofloxacin","ceftazidime","neutropenic fever","2025-08-18",{"date":286,"type":38},"2025-08-22",{"date":288,"type":38},"2025-06-01",{"date":290,"type":21},"2025-12-31",{"name":44,"class":45},{"id":293,"slug":294,"hasResults":11,"nctId":295,"briefTitle":296,"officialTitle":297,"acronym":4,"eligibilityCriteria":298,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":299,"targetDuration":301,"studyType":302,"phases":4,"briefSummary":303,"conditions":304,"keywords":311,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":319,"lastUpdatePostDateStruct":320,"startDateStruct":322,"completionDateStruct":324,"leadSponsor":326,"locationsCount":4},"100602202","comparison-of-diaphragm-ultrasound-and-rsbi-for-predicting-weaning-success-in-mechanically-ventilated-icu-patients-100602202","NCT07120438","Comparison of Diaphragm Ultrasound and RSBI for Predicting Weaning Success in Mechanically Ventilated ICU Patients","Comparison Between Diaphragmatic Ultrasound and Rapid Shallow Breathing Index (RSBI) in Predicting Weaning Success in Patients on Mechanical Ventilation for More Than 48 Hours in the ICU of Dr. Sardjito Hospital, Yogyakarta","Inclusion Criteria:\n\n1. Patients who have been on mechanical ventilation for more than 48 hours\n2. Adult patients aged ≥18 years\n3. Patients who meet the criteria for hemodynamic stability for weaning\n4. Patients or their families have provided written informed consent\n5. Patients with FiO₂ \\\u003C 50%, PEEP level \\\u003C 5 cm H₂O, respiratory rate \\\u003C 30 breaths per minute, PaO₂\u002FFiO₂ \\> 200, and GCS \\> 13\n6. Patients who have successfully completed the Spontaneous Awakening Trial (SAT) and Spontaneous Breathing Trial (SBT)\n\nExclusion Criteria:\n\n1. Patients with neuromuscular disorders, anatomical abnormalities of the diaphragm, or diaphragmatic palsy\n2. Patients with a history of severe thoracic trauma affecting diaphragm function on one or both sides\n3. Pregnancy",{"count":300,"type":21},55,"2 Days","OBSERVATIONAL","The goal of this observational study is to evaluate the predictive value of diaphragmatic ultrasound compared to the Rapid Shallow Breathing Index (RSBI) in determining weaning success among mechanically ventilated patients in the ICU for more than 48 hours.\n\nThe main question it aims to answer is:\n\nWhich is more effective in predicting weaning success: diaphragmatic ultrasound (including Diaphragmatic Excursion \\[DE\\] and Diaphragm Thickening Fraction \\[DTF\\]) or RSBI, in patients ventilated \\>48 hours in the ICU of Dr. Sardjito General Hospital, Yogyakarta?\n\nParticipants will be adult ICU patients who are undergoing weaning from mechanical ventilation after more than 48 hours. Before extubation, each participant will undergo diaphragmatic ultrasound assessment to measure DE and DTF, along with RSBI measurement. The predictive accuracy of these parameters will be evaluated by comparing them with the actual weaning outcomes.\n\nSecondary objectives include:\n\n1. Assessing whether diaphragmatic ultrasound is associated with a higher weaning success rate than RSBI.\n2. Evaluating the correlation between DE values and successful weaning.\n3. Determining the optimal cutoff values of DE and DTF as predictors of weaning failure.\n4. Analyzing the incidence of weaning failure in patients who do not meet optimal diaphragm function criteria.\n5. Identifying DE and DTF thresholds that may help reduce the risk of reintubation.",[305,306,307,308,309,310],"Ventilator Weaning","Mechanical Ventilation","Respiratory Insufficiency Requiring Mechanical Ventilation","Weaning From Mechanical Ventilation","Weaning From Mechanical Ventilation in Care Unit","Intensive Care Unit Patients",[312,313,314,315,316,317,318],"Diaphragmatic Ultrasound","Rapid Shallow Breathing Index","Diaphragm Thickening Fraction","Diaphragm Excursion","Weaning Prediction","ICU","Weaning Failure","2025-08-06",{"date":321,"type":38},"2025-08-13",{"date":323,"type":21},"2025-08",{"date":325,"type":21},"2026-03",{"name":44,"class":45},{"id":328,"slug":329,"hasResults":11,"nctId":330,"briefTitle":331,"officialTitle":331,"acronym":332,"eligibilityCriteria":333,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":334,"targetDuration":4,"studyType":22,"phases":336,"briefSummary":337,"conditions":338,"keywords":341,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":345,"lastUpdatePostDateStruct":346,"startDateStruct":348,"completionDateStruct":350,"leadSponsor":352,"locationsCount":132},"100564153","development-and-implementation-model-of-home-based-cardiac-rehabilitation-with-family-empowerment-approach-in-patient-with-acs-hbcr-in-acs-100564153","NCT06625463","Development and Implementation Model of Home Based Cardiac Rehabilitation With Family Empowerment Approach in Patient With ACS (HBCR in ACS)","HBCR in ACS","Inclusion Criteria:\n\n1. Patients with acute coronary syndrome who have undergone hospitalization, with a minimum home care time of 3 months and a maximum of 1 year, calculated from the day of discharge from the hospital until the time of interview.\n2. Aged 18-65 years, participants were selected with age variations representing young adults, adults and the elderly.\n3. Patients with first experience of SCA, participants were selected whether they had undergone PCI or not.\n4. Patients living with family and family involved in the patient care process.\n5. Physical condition allows for interviews. physical condition is evidenced by examination of stable vital signs (diastolic BP\n\n   \\>90, systolic \\<150 mmhg; N: 60-100x\u002Fmin; S: 36-380c, no pain). Psychological condition does not show symptoms of depression as measured by the Patient Health Questionnaire-9 instrument.\n6. Willing to participate in the study.\n\nExclusion Criteria:\n\n* Patients with comorbidities that require routine medication such as Diabetes Mellitus, hypertension, renal failure",{"count":335,"type":21},90,[24],"The aim of this clinical trial is to determine whether home-based cardiac rehabilitation with a family empowerment approach can help acute coronary syndrome patients recover. The main questions to be answered are:\n\n\\- Does home-based cardiac rehabilitation with a family approach effective in patients with acute coronary syndrome to improve health-related quality of life and peak Vo2? Researchers will compare with usual care to see if home-based cardiac rehabilitation with a family approach is more effective for improving health-related quality of life and peak Vo2 in ACS patients.\n\nPatient inclusion criteria\n\n1. Patients with acute coronary syndrome who had undergone hospitalization, with a minimum home care time of 3 months and a maximum of 1 year, calculated from the day of discharge from the hospital until the time of the interview.\n2. Aged 18-65 years old, participants were selected with age variations representing young adults, adults and the elderly.\n3. Patients with first experience of SCA, participants were selected whether they had undergone PCI or not.\n4. Patients living with family and family involved in the patient care process.\n5. Physical condition allows for interviews. physical condition is evidenced by examination of stable vital signs (diastolic BP\n\n   \\>90, systolic \\<150 mmhg; N: 60-100x\u002Fmin; S: 36-380c, no pain). Psychological condition does not show symptoms of depression as measured by the Patient Health Questionnaire-9 instrument.\n6. Willing to participate in the study.\n\nParticipants will:\n\nFor 12 weeks\n\n1. Perform walking exercises as prescribed\n2. Implement diets and stress management according to the module\n3. Quit smoking\n4. Medication compliance\n5. visit the clinic to see a cardiologist, undergo a 6-minute walk test",[339,340],"Home Based Rehabilitation","Acute Coronary Syndromes",[342,343,344],"home based cardiac rehabilitation","FCEM","acute coronary syndromes","2025-06-11",{"date":347,"type":38},"2025-06-15",{"date":349,"type":38},"2025-01-01",{"date":351,"type":21},"2025-09-30",{"name":44,"class":45},{"id":354,"slug":355,"hasResults":11,"nctId":356,"briefTitle":357,"officialTitle":358,"acronym":4,"eligibilityCriteria":359,"healthyVolunteers":54,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":360,"targetDuration":4,"studyType":22,"phases":362,"briefSummary":363,"conditions":364,"keywords":369,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":375,"lastUpdatePostDateStruct":376,"startDateStruct":378,"completionDateStruct":380,"leadSponsor":382,"locationsCount":46},"100567046","using-nirs-to-evaluate-splanchnic-oxygenation-during-blood-transfusion-in-preterm-infant-100567046","NCT06663085","Using NIRS to Evaluate Splanchnic Oxygenation During Blood Transfusion in Preterm Infant","The Effect of Enteral Feeding on Splanchnic Oxygenation During Blood Transfusion in Preterm Infants","Inclusion Criteria:\n\n* Infant with gestational age \\\u003C 37 weeks\n* Planned to receive blood transfusion\n* Had received minimum 25 ml\u002Fkg\u002Fday enteral feeding\n* in stable condition\n\nExclusion Criteria:\n\n* Infant with multiple congenital anomalies\n* Infant with suspected\u002Fconfirmed genetic anomalies\n* Parents or family did not sign the informed consent",{"count":361,"type":21},42,[24],"To evaluate the differences splanchnic oxygen saturation in preterm infants receiving red blood cell transfusion with and without enteral feeding, and their outcomes.",[365,366,367,368],"Splanchnic Oxygenation","NIRS","PreTerm Neonate","Enteral Feeds",[370,371,372,373,374],"transfusion","nirs","splanchnic oxygenation","preterm neonate","enteral feeds","2024-10-28",{"date":377,"type":38},"2024-10-29",{"date":379,"type":21},"2024-10-30",{"date":381,"type":21},"2025-01-15",{"name":44,"class":45},{"id":384,"slug":385,"hasResults":11,"nctId":386,"briefTitle":387,"officialTitle":388,"acronym":4,"eligibilityCriteria":389,"healthyVolunteers":11,"sex":16,"minAge":390,"maxAge":55,"enrollmentInfo":391,"targetDuration":4,"studyType":22,"phases":393,"briefSummary":394,"conditions":395,"keywords":397,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":399,"lastUpdatePostDateStruct":400,"startDateStruct":402,"completionDateStruct":404,"leadSponsor":406,"locationsCount":132},"100562298","the-effectiveness-of-the-health-promoting-school-intervention-model-in-reducing-overweight-and-obesity-among-school-children-in-indonesia-a-mixed-methods-protocol-study-100562298","NCT06601348","The Effectiveness of the Health Promoting School Intervention Model in Reducing Overweight and Obesity Among School Children in Indonesia: a Mixed-Methods Protocol Study","Effectiveness of a School-Based Nutrition Education and Physical Activity Intervention for Overweight and Obese Children: the Health Promoting School (Hps) Model","Inclusion Criteria:\n\n* Male and female gender\n* Children aged 9-12 years old (at the time of baseline data collection)\n* All fourth and fifth grade students\u002Fchildren\n* Children who are willing as respondents and ready to follow the intervention until completion and willing to fill in the informed consent.\n* Withdrawal: Children experiencing physical and mental health conditions during the intervention (arising due to the child\\'s own health conditions, not due to the effects of the intervention)\n* Full day children\n\nExclusion Criteria:\n\n* Children with clinical conditions \u002F health disorders such as heart disease etc.)\n* Children who did not take the pretest\n* Children who left or moved schools\n* Children who did not complete the intervention","9 Years",{"count":392,"type":21},500,[24],"The prevalence of obesity in children is increasing rapidly, Among children aged 5-12 years, 18.8% have severe overweight, comprising 10.8% who are obese and 8.8% who are over. The development of effective and sustainable intervention strategies to prevent childhood obesity in Indonesia is becoming increasingly important, particularly given the limited implementation of health-promoting schools in the country.\n\nThe first Phase using qualitative exploration was a needs assessment will be using of social cognitive theory. The second Phase will be the development model intervention modification of the health promotion school WHO and \"Health School\". The third Phase is the quantitative stage using a Cluster Randomised Controlled Trial to analyse differences and test the effectiveness of the HPS model. This study will be conducted in 8 primary schools located in Makassar, South Sulawesi. School in Makassar city and schools from outside Makassar city, randomly selected for the trial. Then the selected schools are randomly divided into school for nutrition education and physical activity. Intervention, while school each for comprehensive intervention. The study will be target students in Grades 4 and 5 of primary school. Assessments for the primary objective (BMI Z score), and secondary objectives (change in knowledge, self-efficacy, and health literacy) in thirds study arm. The subsequent phase will assess the efficacy of the intervention in terms of reductions in BMI Z scores, improvements in knowledge, self-efficacy and health literacy. Concurrently, the exploration of parental and teacher knowledge and insights regarding health promotion in schools and its potential in reducing overweight and obesity in children will be conducted.",[396],"Overweight and Obese Children",[398],"Childhood overweight and obesity, health promoting schools, Nutrition Education, Physical activity","2024-09-13",{"date":401,"type":38},"2024-09-19",{"date":403,"type":21},"2024-10-04",{"date":405,"type":21},"2025-06-28",{"name":44,"class":45},{"id":408,"slug":409,"hasResults":11,"nctId":410,"briefTitle":411,"officialTitle":411,"acronym":412,"eligibilityCriteria":413,"healthyVolunteers":54,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":414,"targetDuration":4,"studyType":22,"phases":415,"briefSummary":416,"conditions":417,"keywords":420,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":424,"lastUpdatePostDateStruct":425,"startDateStruct":427,"completionDateStruct":429,"leadSponsor":431,"locationsCount":132},"100555892","collaborative-community-care-for-metastatic-breast-cancer-patients-in-indonesia-communicated-100555892","NCT06517992","Collaborative cOMMUNIty Care for Metastatic breAsT cancEr Patients in inDonesia (Communicated)","Communicated","Inclusion Criteria for mBC:\n\n* Diagnosed for having breast cancer at least in stage 3B or confirm to have metastatic breast cancer\n* Live at home\n* Considered as adult (Eighteen years of age or older)\n\nExclusion Criteria for mBC:\n\n\\- mBC patients will be exclude when their physical condition is deteriorating or when they need hospitalization.\n\nThe following criteria will be applied for family caregivers:\n\n1. Appointed by mBC patients or self-identified as family caregiver of mBC patients for at least 3 months\n2. Live\u002Fnot live together with mBC patients but providing care to mBC patient\n3. Considered as adult (Eighteen years of age or older)\n\nInclusion criteria for cadre:\n\nThe local cadre in Yogyakarta and Bali who self-identified as local cadre in the community and willing to involve for assisting mBC patients. The local cadre will be excluded when they are not providing consent to involve in the current study.",{"count":249,"type":21},[24],"The current study aims to empower local cadres in providing care for metastatic breast cancer (mBC) patients in 2 provinces in Indonesia (Bali and Yogyakarta).",[418,419],"Metastatic Breast Cancer","Cancer",[421,177,422,423,418],"Cadre","Community empowerment","Indonesia","2024-07-20",{"date":426,"type":38},"2024-07-24",{"date":428,"type":21},"2024-09-01",{"date":430,"type":21},"2025-09-01",{"name":44,"class":45},""]