[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Gazi University\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":707},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,67,0,25,[9,55,82,110,148,181,208,241,272,301,325,354,377,403,428,457,484,513,533,563,588,609,632,657,683],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":16,"eligibilityCriteria":17,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":33,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":43,"lastUpdatePostDateStruct":44,"startDateStruct":47,"completionDateStruct":49,"leadSponsor":51,"locationsCount":54},"100645108","randomized-cross-over-comparison-of-medium-cut-off-and-high-flux-hemodialysis-membranes-100645108",false,"NCT07679763","Randomized Cross-Over Comparison of Medium Cut-Off and High-Flux Hemodialysis Membranes","Randomized Cross-Over Evaluation of Medium Cut-Off and High-Flux Hemodialysis Membranes on Inflammation and Cardiovascular Function in Maintenance Hemodialysis Patients","MCO-HD","Inclusion Criteria:\n\n* Age 18 to 80 years.\n* Receiving maintenance hemodialysis for at least 6 months.\n* Clinically stable and receiving thrice-weekly hemodialysis.\n* Able to comply with study procedures, questionnaires, and scheduled assessments.\n* Able and willing to provide written informed consent.\n\nExclusion Criteria:\n\n* Acute infection at screening or enrollment.\n* Major surgery within the previous 3 months.\n* Active malignancy requiring ongoing treatment.\n* Terminal illness with limited life expectancy.\n* Physical or cognitive impairment preventing completion of study procedures or questionnaires.\n* Inability or unwillingness to provide written informed consent.","ALL","18 Years","80 Years",{"count":22,"type":23},30,"ESTIMATED","INTERVENTIONAL",[26],"NA","Patients receiving maintenance hemodialysis are at increased risk of cardiovascular disease, chronic inflammation, endothelial dysfunction, and impaired quality of life. Medium cut-Off (MCO) hemodialysis membranes have been developed to enhance the removal of middle-molecular-weight uremic toxins compared with conventional high-flux membranes, which may improve inflammatory status and cardiovascular health.\n\nThe aim of this study is to compare the effects of MCO and high-flux hemodialysis membranes on inflammatory biomarkers and cardiovascular function in adult patients receiving maintenance hemodialysis. The primary outcomes are changes in serum interleukin-6 (IL-6) and vascular cell adhesion molecule-1 (VCAM-1) levels. Secondary outcomes include arterial stiffness assessed by pulse wave velocity (PWV), body composition assessed by Body Composition Monitor (BCM), handgrip strength, and patient-reported outcomes including quality of life, pruritus, and pain scores.\n\nThis is a prospective, randomized, open-label, two-sequence, two-period crossover study conducted at Gazi University Faculty of Medicine. Thirty adult hemodialysis patients will be randomized to one of two treatment sequences. Participants in Sequence A will receive MCO dialysis membranes for the first 3 months followed by high-flux membranes for the next 3 months. Participants in Sequence B will receive high-flux membranes for the first 3 months followed by MCO membranes for the next 3 months. Blood samples and clinical assessments will be performed at baseline, month 3, and month 6.\n\nThe study is expected to provide evidence regarding the effects of different dialysis membrane technologies on inflammation and cardiovascular health and may contribute to optimizing membrane selection in routine hemodialysis practice.",[29,30,31,32],"End Stage Kidney Disease (ESKD)","Hemodialysis","Cardiovascular Diseases (CVD)","Inflammation",[34,35,36,37,38,32,39,40,41],"End-Stage Kidney Disease","High-Flux Hemodialysis","Medium Cut-Off Membrane","Interleukin-6","VCAM-1","Cardiovascular Function","Pulse Wave Velocity","Body Composition Monitor","NOT_YET_RECRUITING","2026-06-30",{"date":45,"type":46},"2026-07-01","ACTUAL",{"date":48,"type":23},"2026-07",{"date":50,"type":23},"2027-01",{"name":52,"class":53},"Gazi University","OTHER",1,{"id":56,"slug":57,"hasResults":12,"nctId":58,"briefTitle":59,"officialTitle":60,"acronym":4,"eligibilityCriteria":61,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":62,"targetDuration":4,"studyType":64,"phases":4,"briefSummary":65,"conditions":66,"keywords":71,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":4},"100645011","ivc-window-agreement-study-100645011","NCT07676968","IVC Window Agreement Study","Are Subcostal, Transhepatic, and Coronal Windows Interchangeable for IVC Ultrasonography? A Multicenter Prospective Agreement Study","Inclusion Criteria:\n\n* Adult patients (≥18 years) requiring ultrasonographic assessment of intravascular volume status will be consecutively enrolled.\n\nExclusion Criteria:\n\n* Pregnancy, refusal to participate, and inability to obtain any IVC image via the SC approach.",{"count":63,"type":23},900,"OBSERVATIONAL","Ultrasonographic evaluation of the inferior vena cava (IVC) is widely used in emergency and critical care settings for noninvasive assessment of intravascular volume status. The subcostal (SC) window is the standard approach; however, it is frequently limited by obesity, bowel distension, or postoperative anatomical changes. In such cases, the right coronal (RC) and anterior transhepatic (aTH) windows have been proposed as alternatives.",[67,68,69,70],"Emergency Care","Volume Assessment","POCUS","Venous Hemodynamics",[72,73,74,69],"inferior vena cava","ultrasonography","volume status","2026-06-24",{"date":43,"type":46},{"date":78,"type":23},"2026-08-01",{"date":80,"type":23},"2026-12-30",{"name":52,"class":53},{"id":83,"slug":84,"hasResults":12,"nctId":85,"briefTitle":86,"officialTitle":87,"acronym":88,"eligibilityCriteria":89,"healthyVolunteers":12,"sex":90,"minAge":19,"maxAge":91,"enrollmentInfo":92,"targetDuration":4,"studyType":64,"phases":4,"briefSummary":94,"conditions":95,"keywords":99,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":103,"startDateStruct":105,"completionDateStruct":107,"leadSponsor":109,"locationsCount":4},"100644102","female-sexual-function-after-surgery-for-benign-perianal-diseases-100644102","NCT07666035","Female Sexual Function After Surgery for Benign Perianal Diseases","Prospective Evaluation of Female Sexual Function Following Surgical Treatment of Benign Perianal Diseases: A Single-Center Observational Cohort Study","PERISEX","Inclusion Criteria:\n\n* Female patients aged 18-70 years\n* Sexually active during the previous 4 weeks\n* Diagnosed with chronic anal fissure, hemorrhoidal disease, or cryptoglandular anal fistula\n* Scheduled for surgical treatment according to routine clinical indications\n* Able to understand and complete study questionnaires\n* Willing to provide written informed consent\n\nExclusion Criteria:\n\n* Inflammatory bowel disease (Crohn's disease or ulcerative colitis)\n* Pregnancy\n* Postpartum period within the previous 12 months\n* Pelvic organ prolapse\n* Previous treatment for female sexual dysfunction\n* Current antidepressant medication use\n* Active psychiatric disorder\n* Gynecological malignancy\n* Previous pelvic radiotherapy\n* Inability or unwillingness to complete study questionnaires\n* Refusal to provide informed consent","FEMALE","70 Years",{"count":93,"type":23},120,"Benign perianal diseases such as chronic anal fissure, hemorrhoidal disease, and cryptoglandular anal fistula may negatively affect female sexual function through pain, bleeding, discharge, discomfort, and impairment in quality of life. Although improvement in male sexual function after surgery for benign anorectal disorders has been reported, data regarding female sexual function remain limited.\n\nThis prospective observational cohort study aims to evaluate changes in Female Sexual Function Index (FSFI) scores following surgical treatment of benign perianal diseases. Female patients undergoing surgery for chronic anal fissure, hemorrhoidal disease, or cryptoglandular anal fistula will be assessed preoperatively and at postoperative 3 and 6 months using the FSFI, Cleveland Clinic Incontinence Score (CCIS\u002FWexner), and Visual Analog Scale (VAS).\n\nThe primary objective is to determine whether female sexual function improves following surgical treatment. Secondary objectives include evaluating the relationship between symptom improvement, continence status, pain reduction, and changes in female sexual function.",[96,97,98],"Chronic Anal Fissure","Hemorrhoidal Disease","Cryptoglandular Anal Fistula",[98,96,97,100,101,102],"FSFI","Sexual Functions","Perianal Pain",{"date":104,"type":46},"2026-06-26",{"date":106,"type":23},"2026-08",{"date":108,"type":23},"2028-02",{"name":52,"class":53},{"id":111,"slug":112,"hasResults":12,"nctId":113,"briefTitle":114,"officialTitle":115,"acronym":116,"eligibilityCriteria":117,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":118,"targetDuration":120,"studyType":64,"phases":4,"briefSummary":121,"conditions":122,"keywords":128,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":141,"lastUpdatePostDateStruct":142,"startDateStruct":144,"completionDateStruct":145,"leadSponsor":147,"locationsCount":54},"100643888","glp-1-receptor-agonists-and-early-proctologic-effects-in-morbid-obesity-100643888","NCT07668765","GLP-1 Receptor Agonists and Early Proctologic Effects in Morbid Obesity","Early Proctologic Effects of GLP-1 Receptor Agonist Therapy in Morbidly Obese Patients: A Prospective Cohort Study With Baseline and 3-Month Proctologic Assessment","GLP-PROCT","Inclusion Criteria:\n\n* Age ≥18 years\n* Morbid obesity (BMI ≥40 kg\u002Fm² or BMI ≥35 kg\u002Fm² with obesity-related comorbidities)\n* Newly prescribed GLP-1 receptor agonist therapy\n* Ability and willingness to provide written informed consent\n* Ability to attend 3-month follow-up visit\n\nExclusion Criteria:\n\n* Inflammatory bowel disease\n* Perianal Crohn's disease\n* History of anorectal malignancy\n* Previous pelvic radiotherapy\n* Anorectal surgery within the previous 3 months\n* Pregnancy\n* Neurogenic bowel dysfunction\n* Inability to comply with follow-up visits\n* Discontinuation of GLP-1 receptor agonist therapy before follow-up assessment\n* Active anorectal infection or abscess",{"count":119,"type":23},100,"3 Months","Prospective observational cohort study evaluating the early proctologic effects of GLP-1 receptor agonist therapy in morbidly obese patients. Participants will undergo baseline and 3-month anorectal symptom assessment and proctologic examination to evaluate newly developed proctologic diseases and changes in pre-existing symptoms.",[123,124,125,126,127],"Morbid Obesity","Anorectal Diseases","Drug-Related Side Effects and Adverse Reactions","Constipation","Diarrhea",[129,130,131,132,133,134,135,136,137,138,139,140],"GLP-1 receptor agonist","obesity","anorectal symptoms","hemorrhoids","anal fissure","constipation","semaglutide","tirzepatide","proctologic examination","bowel habits","anorectal disease","proctology","2026-06-23",{"date":143,"type":46},"2026-06-25",{"date":106,"type":23},{"date":146,"type":23},"2027-05",{"name":52,"class":53},{"id":149,"slug":150,"hasResults":12,"nctId":151,"briefTitle":152,"officialTitle":153,"acronym":154,"eligibilityCriteria":155,"healthyVolunteers":156,"sex":18,"minAge":19,"maxAge":157,"enrollmentInfo":158,"targetDuration":4,"studyType":64,"phases":4,"briefSummary":160,"conditions":161,"keywords":166,"overallStatus":174,"whyStopped":4,"lastUpdateSubmitDate":175,"lastUpdatePostDateStruct":176,"startDateStruct":177,"completionDateStruct":179,"leadSponsor":180,"locationsCount":54},"100610542","the-role-of-pectoralis-minor-tightness-in-the-development-of-rotator-cuff-tears-100610542","NCT07228936","The Role of Pectoralis Minor Tightness in the Development of Rotator Cuff Tears","The Role of Pectoralis Minor Muscle Tightness in the Development of Rotator Cuff Tears: A Propensity Score Matched Case-Control Study","PMinor-Rotator","Inclusion criteria consisted of patients aged 18-55 years who were scheduled to undergo surgical treatment for a partial-thickness rotator cuff tear (case group) and individuals aged 18-55 years with no evidence of rotator cuff or other shoulder pathology on magnetic resonance imaging (control group). Patients were excluded if they had a history of trauma, thoracic outlet syndrome, systemic inflammatory disease, prior surgery on the affected shoulder, and declined participation in the examination.",true,"55 Years",{"count":159,"type":23},90,"This study investigates whether tightness of a small chest muscle called the pectoralis minor is associated with the development of partial rotator cuff tears in the shoulder. Using a propensity score matched case-control design, the study compares patients with rotator cuff tears (case group, n=45) to patients with intact rotator cuffs (control group, n=45).\n\nAdults aged 18-55 with shoulder pain who are evaluated by MRI and\u002For shoulder arthroscopy at Gazi University Hospital may be invited. The case group includes patients found to have partial rotator cuff tears during arthroscopy. The control group includes patients whose rotator cuff was documented as intact by MRI. Groups are matched 1:1 on age, sex, BMI, and dominant side.\n\nBefore surgery, two trained clinician measures shoulder posture and pectoralis minor length using simple external tools (a digital caliper and ruler-like square). For arthroscopy patients, the surgeon records general arthroscopic findings. No extra procedures are added for research.\n\nWe expect to include 90 participants total. The primary hypothesis is that pectoralis minor tightness is more prevalent in patients with rotator cuff tears compared to controls. A secondary hypothesis is that tears in patients with pectoralis minor tightness more often partial-thickness bursal side rotator cuff tear. Results may help clinicians understand shoulder mechanics and improve prevention or rehabilitation strategies.",[162,163,164,165],"Shoulder Impingement Syndrome","Rotator Cuff Injuries","Pectoralis Minor Tightness","Pectoralis Minor Muscle Tension",[167,163,168,169,170,171,172,173],"rotator cuff","Posture","Scapula","Pectoralis Muscles","Arthroscopy","Shoulder Joint","Pectoralis Minor","RECRUITING","2026-06-20",{"date":143,"type":46},{"date":178,"type":46},"2025-03-18",{"date":43,"type":23},{"name":52,"class":53},{"id":182,"slug":183,"hasResults":12,"nctId":184,"briefTitle":185,"officialTitle":186,"acronym":4,"eligibilityCriteria":187,"healthyVolunteers":12,"sex":18,"minAge":188,"maxAge":4,"enrollmentInfo":189,"targetDuration":4,"studyType":64,"phases":4,"briefSummary":191,"conditions":192,"keywords":196,"overallStatus":174,"whyStopped":4,"lastUpdateSubmitDate":200,"lastUpdatePostDateStruct":201,"startDateStruct":203,"completionDateStruct":205,"leadSponsor":207,"locationsCount":54},"100643541","physical-therapy-program-and-treatment-expectations-in-knee-osteoarthritis-100643541","NCT07618403","Physical Therapy Program and Treatment Expectations in Knee Osteoarthritis","Evaluating The Predictive Effect of Treatment Expectations on Response to A Physical Therapy Program in Patients With Knee Osteoarthritis","Inclusion Criteria:\n\n* Agreeing to participate in the study\n* Being over 50 years of age\n* Having a clinically and radiographically confirmed diagnosis of knee osteoarthritis\n* Having grade 2-3-4 knee osteoarthritis according to the Kellgren-Lawrence grading system\n* Being literate\n\nExclusion Criteria:\n\n* Previous knee surgery\n* Conditions that prevent exercise (such as incurable malignancy, active systemic infection, non-union fracture)\n* Presence of accompanying neurological disease affecting the lower extremity\n* Severe cognitive impairment (neuropsychiatric disease or condition that will impede cooperation, such as psychosis, dementia)\n* History of having received injections or other procedures to the knee joint or physical therapy within the last 6 months","50 Years",{"count":190,"type":23},84,"To our knowledge, no studies have been conducted in the literature investigating the relationship between the success of physical therapy programs applied in knee osteoarthritis and patients' pre-treatment expectations. The rationale for this study is to demonstrate the possible relationship between treatment expectations and the benefits seen from conventional physical therapy programs in patients with knee osteoarthritis, and to provide clinicians with a different perspective in knee osteoarthritis treatment planning.",[193,194,195],"Gonarthrosis; Primary","Physical Therapy","Patients' Expectations",[197,198,199],"treatment expectations","gonarthrosis","physical treatment","2026-06-08",{"date":202,"type":46},"2026-06-10",{"date":204,"type":46},"2026-01-01",{"date":206,"type":23},"2027-09-15",{"name":52,"class":53},{"id":209,"slug":210,"hasResults":12,"nctId":211,"briefTitle":212,"officialTitle":213,"acronym":4,"eligibilityCriteria":214,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":215,"targetDuration":4,"studyType":24,"phases":217,"briefSummary":218,"conditions":219,"keywords":225,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":233,"lastUpdatePostDateStruct":234,"startDateStruct":236,"completionDateStruct":238,"leadSponsor":240,"locationsCount":54},"100638885","extracorporeal-shock-wave-therapy-in-lower-extremity-lymphedema-100638885","NCT07626645","Extracorporeal Shock Wave Therapy in Lower Extremity Lymphedema","Efficacy of Extracorporeal Shock Wave Therapy (ESWT) in Lower Extremity Lymphedema: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Adults aged 18 to 80 years\n* Clinical diagnosis of lower extremity lymphedema established at least 6 months prior to enrollment\n* Completion of at least one cycle of CDT Phase 1 (intensive decongestive phase) within the preceding six months\n* Currently in CDT Phase 2 (maintenance phase) with active use of compression garments\n* Ability and willingness to provide written informed consent\n\nExclusion Criteria:\n\n* Active chemotherapy or radiotherapy\n* Active infection\n* Lower extremity vascular diseases including deep vein thrombosis or arterial insufficiency\n* Presence of a cardiac pacemaker\n* Pregnancy\n* Bleeding disorders",{"count":216,"type":23},36,[26],"Lower extremity lymphedema is a chronic and progressive condition associated with significant functional impairment and reduced quality of life. The current gold-standard treatment is Complex Decongestive Therapy (CDT); however, a substantial proportion of patients continue to experience persistent symptoms during the maintenance phase. This prospective, randomized, double-blind, placebo-controlled clinical trial aims to evaluate the effectiveness of Extracorporeal Shock Wave Therapy (ESWT) as an adjunct to standard CDT maintenance therapy in patients with lower extremity lymphedema. Participants will be randomly allocated to either an active ESWT group or a sham ESWT group, with both groups continuing standard CDT maintenance throughout the study. ESWT will be administered twice weekly for five sessions. Changes in limb volume, skin thickness and subcutaneous tissue thickness assessed by ultrasonography, pain, functional status, and quality of life will be evaluated at baseline, after treatment, and at one-month follow-up.",[220,221,222,223,224],"Lymphedema, Lower Limb","Extracorporeal Shock Wave Therapy","Edema Leg","Sham-controlled","Placebo Control Design",[226,227,228,229,230,231,232],"Lower Extremity Lymphedema","Extracorporeal Shock Wave Therapy (ESWT)","Complex Decongestive Therapy (CDT)","Limb Volume","Ultrasonography","skin and subcutaneous tissue thickness","Quality of Life","2026-06-02",{"date":235,"type":46},"2026-06-04",{"date":237,"type":23},"2026-06-22",{"date":239,"type":23},"2027-02-01",{"name":52,"class":53},{"id":242,"slug":243,"hasResults":12,"nctId":244,"briefTitle":245,"officialTitle":246,"acronym":247,"eligibilityCriteria":248,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":249,"targetDuration":251,"studyType":64,"phases":4,"briefSummary":252,"conditions":253,"keywords":256,"overallStatus":174,"whyStopped":4,"lastUpdateSubmitDate":264,"lastUpdatePostDateStruct":265,"startDateStruct":267,"completionDateStruct":269,"leadSponsor":270,"locationsCount":271},"100623240","real-world-comparison-of-chemo-immunotherapy-regimens-in-metastatic-nsclc-with-pd-l1-50-alcg-01-100623240","NCT07394062","Real-World Comparison of Chemo-Immunotherapy Regimens in Metastatic NSCLC With PD-L1 \u003C50% (ALCG-01)","A Prospective Observational Study Comparing Chemotherapy Plus Pembrolizumab Versus Nivolumab Plus Ipilimumab With Chemotherapy in Patients With Metastatic Non-Small Cell Lung Cancer and PD-L1 Expression Below 50%","ALCG-01","Inclusion Criteria:\n\n* Age ≥18 years.\n* Histologically or cytologically confirmed non-small cell lung cancer.\n* Metastatic (stage IV) disease at the time of study entry.\n* Tumor PD-L1 expression \\\u003C50%.\n* Initiation of first-line systemic treatment with either chemotherapy plus pembrolizumab or nivolumab plus ipilimumab in combination with chemotherapy, according to routine clinical practice.\n* Ability to provide informed consent.\n\nExclusion Criteria:\n\n* Prior systemic therapy for metastatic non-small cell lung cancer.\n* Participation in an interventional clinical trial that mandates treatment assignment.\n* Presence of another active malignancy requiring systemic treatment.\n* Inability to comply with routine clinical follow-up or data collection.",{"count":250,"type":23},400,"18 Months","Patients with metastatic non-small cell lung cancer (NSCLC) and programmed death-ligand 1 (PD-L1) expression below 50% are commonly treated with different chemo-immunotherapy regimens in routine clinical practice. Although these regimens are widely used, comparative real-world data on survival outcomes and patient-reported quality of life are limited.\n\nThis prospective observational study aims to compare two commonly used treatment approaches in patients with metastatic NSCLC and PD-L1 expression \\\u003C50%: chemotherapy plus pembrolizumab versus nivolumab plus ipilimumab combined with chemotherapy. Patients will receive treatment according to routine clinical decisions made by their treating physicians; no treatment assignment or intervention will be performed as part of the study.\n\nThe primary outcomes of the study are progression-free survival and overall survival. In addition, health-related quality of life will be assessed using validated patient-reported outcome questionnaires during routine follow-up.\n\nExploratory analyses will examine treatment outcomes in relation to selected clinical and patient-related factors, such as biological age, antibiotic exposure, and dietary patterns, in subsets of patients with available data.\n\nThe results of this study are expected to provide real-world evidence on survival and quality of life outcomes associated with commonly used chemo-immunotherapy strategies in metastatic NSCLC.",[254,255],"Nonsmall Cell Lung Cancer, Stage IV","Metastatic Nonsmall Cell Lung Cancer",[257,258,259,260,261,262,232,263],"NSCLC","Metastatic Lung Cancer","Chemo-Immunotherapy","PD-L1","Progression-Free Survival","Overall Survival","Patient-Reported Outcomes","2026-05-14",{"date":266,"type":46},"2026-05-18",{"date":268,"type":46},"2026-02-01",{"date":108,"type":23},{"name":52,"class":53},2,{"id":273,"slug":274,"hasResults":12,"nctId":275,"briefTitle":276,"officialTitle":277,"acronym":278,"eligibilityCriteria":279,"healthyVolunteers":12,"sex":18,"minAge":120,"maxAge":280,"enrollmentInfo":281,"targetDuration":4,"studyType":24,"phases":283,"briefSummary":284,"conditions":285,"keywords":289,"overallStatus":174,"whyStopped":4,"lastUpdateSubmitDate":293,"lastUpdatePostDateStruct":294,"startDateStruct":296,"completionDateStruct":298,"leadSponsor":300,"locationsCount":54},"100638936","safe-early-intervention-for-at-risk-infants-100638936","NCT07596147","SAFE Early Intervention for At-Risk Infants","Investigation of the Effectiveness of the SAFE Early Intervention Approach on Upper Extremity Function, Fine Motor Skills, and Quality of Life in High-Risk Infants","SAFE-EFFECT","Inclusion Criteria:\n\n* Infants aged between 3 and 12 months corrected age Presence of neurodevelopmental risk factors including perinatal stroke, perinatal asphyxia, hypoxic-ischemic encephalopathy, germinal matrix hemorrhage, intraventricular hemorrhage, periventricular leukomalacia, or prematurity at or below 37 weeks of gestation Admission to the Developmental Pediatrics and Pediatric Physiotherapy and Rehabilitation Unit of Gazi University Faculty of Health Sciences Parent or legal guardian willing to participate and provide written informed consent\n\nExclusion Criteria:\n\n* Presence of any congenital anomaly Diagnosis of a genetic disorder Any orthopedic problem affecting upper extremity function Families unable to communicate in Turki","12 Months",{"count":282,"type":23},34,[26],"This randomized controlled study aims to investigate the effects of the SAFE early intervention approach on upper extremity function, fine motor skills, and developmental outcomes in high-risk infants aged 3-12 months. Thirty high-risk infants admitted to the Developmental Physiotherapy and Pediatric Rehabilitation Unit of Gazi University Faculty of Health Sciences will be randomly assigned to either the SAFE early intervention group or the Neurodevelopmental Treatment (NDT) group.\n\nInfants in the intervention group will receive the SAFE early intervention program for 8 weeks under the supervision of an experienced pediatric physiotherapist. The SAFE approach includes age-appropriate activities focusing on environmental enrichment, promotion of voluntary and goal-directed movements, sensory stimulation, fine motor skill development, postural control, transitional movements, and enhancement of infant-parent interaction through daily routines and home-based activities.\n\nInfants in the control group will receive conventional Neurodevelopmental Treatment (NDT) for 8 weeks. The NDT program includes age-specific activities targeting postural control, muscle tone regulation, facilitation of motor development, hand function, balance, weight transfer, and fine motor skills.\n\nFamilies will receive education regarding home-based activities and facilitation techniques specific to their infant's developmental needs. Follow-up will include home visits and weekly telephone monitoring to ensure adherence to the intervention program. Assessments will be performed before the intervention and after the 8-week intervention period by a physiotherapist blinded to group allocation.",[286,287,288],"High Risk Infant","Neurodevelopmental Disorder (Diagnosis)","Preterm",[290,291,292],"early intervention","high risk infant","upper limb function","2026-05-13",{"date":295,"type":46},"2026-05-19",{"date":297,"type":46},"2026-02-16",{"date":299,"type":23},"2026-07-16",{"name":52,"class":53},{"id":302,"slug":303,"hasResults":12,"nctId":304,"briefTitle":305,"officialTitle":306,"acronym":307,"eligibilityCriteria":308,"healthyVolunteers":156,"sex":18,"minAge":4,"maxAge":4,"enrollmentInfo":309,"targetDuration":4,"studyType":24,"phases":311,"briefSummary":312,"conditions":313,"keywords":4,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":317,"lastUpdatePostDateStruct":318,"startDateStruct":320,"completionDateStruct":322,"leadSponsor":324,"locationsCount":4},"100635128","mind-mapping-impact-on-critical-thinking-and-problem-solving-skills-100635128","NCT07548658","Mind Mapping: Impact on Critical Thinking and Problem-Solving Skills","Visualizing Thought Through Mind Mapping: A Randomized Controlled Trial on Critical Thinking and Problem-Solving Skills Among Nursing Students","Mind mapping","Inclusion Criteria:\n\n* Students who are enrolling in the Critical Thinking in Nursing course for the first time and\n* who volunteer to participate in the study\n\nExclusion Criteria:\n\n* Students who have previously taken the critical thinking course\n* The student's refusal to continue participating in the study or failure to complete the data collection forms.",{"count":310,"type":23},65,[26],"This randomized controlled trial aims to evaluate the effectiveness of the mind mapping method in enhancing critical thinking and problem-solving skills among nursing students. The study will be conducted with 65 nursing students enrolled in a \"Critical Thinking in Nursing\" course at Gazi University during the 2025-2026 academic year. Participants will be assigned to experimental and control groups using stratified randomization based on pre-test scores from the \"Marmara Critical Thinking Tendencies Scale\" and the \"Problem-Solving Inventory.\"\n\nThe five-week intervention focuses on five clinical case studies: infection control, medication administration, patient safety, ethical issues, and systematic approaches. While both groups receive the same theoretical content, they follow different practical methodologies:\n\nThe Control Group will engage in standard case analysis methods. The Experimental Group will work in small teams (4-5 students) to create and present visual mind maps for each case study, using either traditional or digital tools.\n\nFollowing the intervention, both groups will complete post-tests to assess changes in their critical thinking and problem-solving competencies.",[314,315,316],"Mind Mapping","Nursing Students","Critical Thinking","2026-04-23",{"date":319,"type":46},"2026-04-29",{"date":321,"type":23},"2026-04-22",{"date":323,"type":23},"2026-05-29",{"name":52,"class":53},{"id":326,"slug":327,"hasResults":12,"nctId":328,"briefTitle":329,"officialTitle":329,"acronym":4,"eligibilityCriteria":330,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":331,"enrollmentInfo":332,"targetDuration":4,"studyType":24,"phases":334,"briefSummary":335,"conditions":336,"keywords":342,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":321,"lastUpdatePostDateStruct":347,"startDateStruct":349,"completionDateStruct":351,"leadSponsor":353,"locationsCount":54},"100635371","the-effect-of-art-based-intervention-on-fatigue-anxiety-perception-of-nurse-presence-and-quality-of-life-in-patients-with-hematological-cancers-100635371","NCT07551817","The Effect of Art-Based Intervention on Fatigue, Anxiety, Perception of Nurse Presence, and Quality of Life in Patients With Hematological Cancers","Inclusion Criteria:\n\n* Being between 18 and 65 years of age\n* Speaking and understanding Turkish\n* Being literate\n* Having a diagnosis of hematological cancer,\n* Receiving chemotherapy in an inpatient ward,\n* Not having a psychiatric diagnosis,\n* Having an ECOG score of 1 or 2,\n\nExclusion Criteria:\n\n* Having vision loss and hearing loss,\n* Having an ECOG score of 3 or 4\n* Patients who wanted to leave the study\n* Failure to attend at least two sessions of art therapy.","65 Years",{"count":333,"type":23},52,[26],"This study will be conducted in a randomized controlled experimental design to examine The effect of art-based intervention on fatigue, anxiety, perception of nurse presence, and quality of life in patients with hematological cancer. The study will be conducted with 52 patients (26 intervention, 26 control groups) treated in the Hematology department of a training and research hospital between May 2025 and October 2026. Art-based intervention will be applied to the intervention group for 2 week (3 sessions per week), No application will be made to the control group. The data collection tools in the study are the Patient Identifier Information Form, Cancer Fatigue Scale, Functional Assessment of Cancer Therapy-General Scale (FACT-G), Hospital Anxiety and Depression Scale (HADS), and Nurse Presence Scale (PONS).",[337,338,339,232,340,341],"Art-based Intervention","Hematological Cancer","Nurse Presence","Fatigue","Anxiety",[343,344,345,346,340,341],"Art-based intervention","Hematological cancer","Nurse presence","Quality of life",{"date":348,"type":46},"2026-04-27",{"date":350,"type":23},"2026-05-01",{"date":352,"type":23},"2026-12-31",{"name":52,"class":53},{"id":355,"slug":356,"hasResults":12,"nctId":357,"briefTitle":358,"officialTitle":359,"acronym":4,"eligibilityCriteria":360,"healthyVolunteers":156,"sex":18,"minAge":361,"maxAge":362,"enrollmentInfo":363,"targetDuration":4,"studyType":24,"phases":365,"briefSummary":366,"conditions":367,"keywords":369,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":371,"lastUpdatePostDateStruct":372,"startDateStruct":373,"completionDateStruct":375,"leadSponsor":376,"locationsCount":4},"100634775","the-effect-of-health-education-on-childrens-healthy-lifestyle-skills-100634775","NCT07544069","The Effect of Health Education on Children's Healthy Lifestyle Skills","The Effect of Health Education on Children's Healthy Lifestyle Skills: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Enrolled at Şehit Yavuz Başayar Primary School\n* Currently attending 2nd, 3rd, or 4th grade\n* Willing to participate in the study\n* Having parental consent\n\nExclusion Criteria:\n\n* Refusal to participate in the study\n* Lack of parental consent\n* Inability to complete the data collection tools","8 Years","10 Years",{"count":364,"type":23},526,[26],"Childhood is a critical period for the development of lifelong health behaviors, and early interventions play an essential role in promoting long-term health and preventing future health problems. This study is planned to evaluate the effect of health education on children's healthy lifestyle skills.",[368],"Healthy Lifestyle Behaviors",[370],"Health Education, Child, Primary School, Health Behavior, Nursing","2026-04-18",{"date":321,"type":46},{"date":374,"type":23},"2026-04-15",{"date":43,"type":23},{"name":52,"class":53},{"id":378,"slug":379,"hasResults":12,"nctId":380,"briefTitle":381,"officialTitle":382,"acronym":4,"eligibilityCriteria":383,"healthyVolunteers":156,"sex":18,"minAge":384,"maxAge":20,"enrollmentInfo":385,"targetDuration":386,"studyType":64,"phases":4,"briefSummary":387,"conditions":388,"keywords":392,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":397,"lastUpdatePostDateStruct":398,"startDateStruct":400,"completionDateStruct":401,"leadSponsor":402,"locationsCount":54},"100634487","effects-of-cognitive-dual-task-on-gait-in-parkinsons-disease-100634487","NCT07540325","Effects of Cognitive Dual-Task on Gait in Parkinson's Disease","Investigating the Effects of Cognitive Dual-Task on Gait in Individuals With Parkinson's Disease","Inclusion Criteria for Individuals with Parkinson's Disease:\n\n* A clinical diagnosis of Parkinson's Disease confirmed by a neurologist according to the United Kingdom Parkinson's Disease Society Brain Bank diagnostic criteria\n* Classified between stages 1 and 3 according to the Modified Hoehn and Yahr Staging Scale\n* Aged between 40 and 80 years\n* A score of at least 21 on the Montreal Cognitive Assessment (MoCA)\n* Ability to walk continuously for at least 10 minutes without interruption and without the use of any assistive walking device\n* Having received at least 5 years of formal education\n\nExclusion Criteria for Individuals with Parkinson's Disease:\n\n* Presence of any neurological disorder other than Parkinson's Disease\n* Presence of any cardiopulmonary or musculoskeletal condition that may impair safe ambulation\n* A score of ≥10 for anxiety and ≥7 for depression on the Hospital Anxiety and Depression Scale (HADS)\n* Presence of visual or auditory impairments that cannot be corrected with assistive devices\n\nInclusion Criteria for Healthy Individuals:\n\n* Aged between 40 and 80 years\n* A score of at least 21 on the Montreal Cognitive Assessment (MoCA)\n\nExclusion Criteria for Healthy Individuals:\n\n* Presence of any neurological disorder\n* Presence of any cardiopulmonary or musculoskeletal condition that may affect safe ambulation\n* A score of ≥10 for anxiety and ≥7 for depression on the Hospital Anxiety and Depression Scale (HADS)\n* Presence of visual or auditory impairments that cannot be corrected with assistive devices","40 Years",{"count":22,"type":23},"2 Days","The aim of this study is to evaluate gait in individuals diagnosed with PD under tasks involving different cognitive domains, to compare the results with those of age and sex-matched healthy individuals, and to determine which cognitive function has the greatest impact on gait in PD.",[389,390,391],"Parkinson's Disease (PD)","Cognition","Gait Disorders",[393,394,395,396],"Gait","Cognitive Function","Dual-Task","Parkinson's Disease","2026-04-17",{"date":399,"type":46},"2026-04-20",{"date":399,"type":23},{"date":352,"type":23},{"name":52,"class":53},{"id":404,"slug":405,"hasResults":12,"nctId":406,"briefTitle":407,"officialTitle":408,"acronym":409,"eligibilityCriteria":410,"healthyVolunteers":156,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":411,"targetDuration":4,"studyType":24,"phases":413,"briefSummary":414,"conditions":415,"keywords":416,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":374,"lastUpdatePostDateStruct":422,"startDateStruct":423,"completionDateStruct":425,"leadSponsor":427,"locationsCount":4},"100634832","puzzle-based-learning-on-nursing-students-parenteral-medication-knowledge-and-motivation-100634832","NCT07544810","Puzzle-Based Learning on Nursing Students' Parenteral Medication Knowledge and Motivation","The Effect of Crossword-Based Learning on Parenteral Drug Administration on Nursing Students' Knowledge Level, Self-Efficacy Perception, and Learning Motivation","→ PIM-Crosswor","Inclusion Criteria:\n\nBeing enrolled as a 2nd-year student in the Nursing Department of the Faculty of Health Sciences at Kütahya Health Sciences University.\n\n• Being registered for the \"Fundamental Principles and Practices in Nursing\" course.\n\nExclusion Criteria:\n\n* Not completing the pre-test or post-test data collection forms.\n\n  * Being on medical or academic leave during the study period.\n  * Having previously received structured training related to parenteral medication administration within the past 6 months.\n  * Participating in another educational intervention study at the same time.",{"count":412,"type":23},80,[26],"This randomized, controlled, parallel-group, interventional study aims to evaluate the effects of Crossword-Based Learning for Parenteral Drug Administration on the knowledge level, self-efficacy perception, and learning motivation of Nursing Department students. It is considered original because it examines the effects of crossword-based learning on cognitive and psychosocial outcomes in parenteral drug administration, a skill with a high risk of error in the clinical field. The study will be conducted with 80 (40 Experimental, 40 Control) nursing students selected through a power analysis. Participants will be assigned to groups by random assignment, and the study will be conducted in accordance with the triple-blind principle (participant, data collector, statistician). The experimental group will receive Crossword Activities in four different phases (Initial, Theoretical, Laboratory, and Post-Clinical Practice) in addition to the standard educational content. The control group will only complete the standard education. The primary outcomes of the study are; At the end of the 4th stage, the Parenteral Drug Administration Knowledge Test will be evaluated based on the Safe Parenteral Drug Administration Self-Efficacy Scale (SES-SES) and the Higher Education Learning Motivation Scale (SLS-SES) scores.",[315],[417,418,419,420,421],"nursing student","Crossword puzzle","drug administration","motivation","self-sufficiency",{"date":321,"type":46},{"date":424,"type":23},"2026-04-28",{"date":426,"type":23},"2026-09-15",{"name":52,"class":53},{"id":429,"slug":430,"hasResults":12,"nctId":431,"briefTitle":432,"officialTitle":432,"acronym":433,"eligibilityCriteria":434,"healthyVolunteers":12,"sex":18,"minAge":4,"maxAge":4,"enrollmentInfo":435,"targetDuration":4,"studyType":24,"phases":436,"briefSummary":437,"conditions":438,"keywords":441,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":449,"lastUpdatePostDateStruct":450,"startDateStruct":452,"completionDateStruct":454,"leadSponsor":456,"locationsCount":54},"100632785","the-effect-of-an-artificial-intelligence-supported-virtual-reality-simulation-on-nursing-students-holistic-care-skills-100632785","NCT07518199","The Effect of an Artificial Intelligence-Supported Virtual Reality Simulation on Nursing Students' Holistic Care Skills","AI-VRS","Inclusion Criteria:\n\n* Voluntary participation in the study,\n* Having enrolled for the first time in the courses HEM 402 Professional Practice I and HEM 404 Professional Practice II in the Department of Nursing, Faculty of Health Sciences,\n* Absence of eye conditions affecting depth perception, such as amblyopia (lazy eye), anisometropia(different refractive errors in each eye), and strabismus (squint). (Self- report is accepted.),\n* Academic performance score between 2.00 and 4.00.,\n\nExclusion Criteria:\n\n* Having received training in holistic care skills in addition to their undergraduate nursing degree,\n* Having experience with virtual simulation exercises focused on holistic care skills,\n* Holding a high school, foundation year or undergraduate degree in a health-related field,\n* Having difficulty understanding and speaking Turkish,\n\nCriteria for Exclusion from the Study:\n\n* The participant has not completed or has incompletely completed the required forms and scales,\n* The participant in the experimental group had not taken part in or completed the AI-supported virtual reality simulation,\n* Students in the control group did not take part in the educational case study,\n* Students in the experimental and control groups did not take part in the assessment case study,\n* The participant wishes to withdraw from the study,",{"count":412,"type":23},[26],"This study aims to evaluate the effect of artificial intelligence (AI)-supported virtual reality (VR) simulation on nursing students' holistic care skills. The study is a randomised controlled trial involving fourth-year nursing students, divided into an experimental and a control group. Whilst the experimental group will receive AI-supported VR simulation training, the control group will receive traditional case-based training. Outcomes to be assessed include decision-making, symptom identification, nursing diagnosis, simulation design and satisfaction with the training methods.",[315,439,440],"Decision-Making","Diagnostic Reasoning",[442,443,444,445,446,447,448],"Artificial Intelligence","Simulation Training","Immersive Virtual Reality","Nursing Education","Holistic Care","Nursing Diagnoses","Educational Technology","2026-04-04",{"date":451,"type":46},"2026-04-08",{"date":453,"type":23},"2026-04",{"date":455,"type":23},"2026-05",{"name":52,"class":53},{"id":458,"slug":459,"hasResults":12,"nctId":460,"briefTitle":461,"officialTitle":462,"acronym":4,"eligibilityCriteria":463,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":157,"enrollmentInfo":464,"targetDuration":4,"studyType":24,"phases":465,"briefSummary":466,"conditions":467,"keywords":469,"overallStatus":174,"whyStopped":4,"lastUpdateSubmitDate":476,"lastUpdatePostDateStruct":477,"startDateStruct":479,"completionDateStruct":481,"leadSponsor":483,"locationsCount":54},"100631903","effects-of-different-graston-technique-application-speeds-on-trapezius-muscle-stiffness-pressure-pain-threshold-pain-and-muscle-oxygenation-in-patients-with-bruxism-100631903","NCT07506733","Effects of Different Graston Technique Application Speeds on Trapezius Muscle Stiffness, Pressure Pain Threshold, Pain, and Muscle Oxygenation in Patients With Bruxism","A Study on the Effects of Different Application Speeds of the Graston Technique on Trapezius Muscle Stiffness, Pressure Pain Threshold, Pain Intensity, and Muscle Oxygenation in Individuals With Bruxism","Inclusion Criteria:\n\n* Diagnosed with bruxism.\n* Aged 18-55 years.\n* Presence of trigger points in the trapezius muscle, according to the criteria defined by Travell and Simons.\n\nExclusion Criteria:\n\n* Acute tears, tendon ruptures, or severe muscle injuries.\n* Conditions that prevent the application of the Graston Technique (e.g., skin lesions, open wounds, infections).\n* Having received botox injections in the temporomandibular joint (TMJ) region within the last 6 months.\n* Psychological disorders that may affect participation or measurements.",{"count":282,"type":23},[26],"This randomized crossover study aims to address an important gap in manual therapy by examining the acute physiological effects of different Graston Technique application speeds (60 BPM vs. 120 BPM) on the dominant upper trapezius muscle in patients with bruxism. Although the Graston Technique is widely used, the specific impact of application speed on parameters such as muscle stiffness, muscle oxygenation, pressure pain threshold, and pain intensity remains under-investigated. By utilizing a crossover design with a 1-week washout period, this study allows for a precise within-subject comparison of the two speeds. The findings will clarify the optimal application frequency, providing objective data to guide the development of more effective, evidence-based manual therapy protocols for bruxism management.",[468],"Bruxism",[470,471,472,473,474,475],"Graston technique","muscle stiffness","trapezius","oxygenation","pain","trigger points","2026-03-28",{"date":478,"type":46},"2026-04-02",{"date":480,"type":46},"2025-03-25",{"date":482,"type":23},"2026-04-30",{"name":52,"class":53},{"id":485,"slug":486,"hasResults":12,"nctId":487,"briefTitle":488,"officialTitle":489,"acronym":490,"eligibilityCriteria":491,"healthyVolunteers":12,"sex":18,"minAge":492,"maxAge":4,"enrollmentInfo":493,"targetDuration":4,"studyType":24,"phases":495,"briefSummary":496,"conditions":497,"keywords":501,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":505,"lastUpdatePostDateStruct":506,"startDateStruct":508,"completionDateStruct":510,"leadSponsor":512,"locationsCount":4},"100631452","gamification-in-stoma-care-education-for-nursing-students-100631452","NCT07500857","Gamification in Stoma Care Education for Nursing Students","The Effect of the Gamification Method on Nursing Students' Learning of Stoma Care","GAME-STOMA","Inclusion Criteria:\n\n* Nursing students who voluntarily agree to participate in the study\n* Students who are enrolled in the \"Nursing Professional Practice\" course for the first time\n* Students who have access to a mobile device (e.g., smartphone or tablet) and internet connection\n\nExclusion Criteria:\n\n* Students who have previously participated in or used any game related to stoma care\n* Students who do not attend the theoretical course\n* Students who do not participate in demonstrations or group activities\n* Students who do not complete any stage of the knowledge assessment\n* Students who do not complete any stage of the skill assessment\n* Students who provide incomplete or careless responses to data collection forms\n* Students who do not use or complete the game-based intervention","17 Years",{"count":494,"type":23},72,[26],"his study aims to determine the effect of a gamification-based educational method on nursing students' learning of stoma care. The research will be conducted as a pretest-posttest, parallel-group randomized controlled experimental study. This research will be prepared under the guidance of the Standard Protocol Items: Recommendations for Interventional Trials (SPIRIT) protocol, and the reporting of the randomized controlled study will be carried out under the Consolidated Standards of Reporting Trials (CONSORT).\n\nParticipants will consist of fourth-year nursing students who voluntarily agree to participate in the study. After obtaining informed consent, participants will complete a descriptive characteristics form and the Stoma Care Knowledge Test. Randomization will be performed based on baseline knowledge levels, and participants will be assigned to experimental and control groups.\n\nStudents' knowledge levels will be assessed using the \"Stoma Care Knowledge Test,\" and their skills will be evaluated using a \"Skills Checklist.\" Following baseline knowledge and skill assessment, the experimental group will receive gamified stoma care education, while the control group will receive standard education. The gamification intervention is designed based on the Werbach D6 Model and aims to enhance students' knowledge and skills in stoma care.\n\nPost-intervention knowledge and skill assessments will be conducted one week after the training. In addition, follow-up measurements will be performed four weeks later to evaluate the retention of knowledge and skills.",[498,499,445,500],"Stoma Care Education in Nursing Students","Gamification","Ostomy - Ileostomy or Colostomy",[502,503,504],"gamification","nursing education","stoma care","2026-03-24",{"date":507,"type":46},"2026-03-30",{"date":509,"type":23},"2026-03-27",{"date":511,"type":23},"2026-04-24",{"name":52,"class":53},{"id":514,"slug":515,"hasResults":12,"nctId":516,"briefTitle":517,"officialTitle":518,"acronym":4,"eligibilityCriteria":519,"healthyVolunteers":156,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":520,"targetDuration":4,"studyType":64,"phases":4,"briefSummary":522,"conditions":523,"keywords":4,"overallStatus":174,"whyStopped":4,"lastUpdateSubmitDate":527,"lastUpdatePostDateStruct":528,"startDateStruct":529,"completionDateStruct":531,"leadSponsor":532,"locationsCount":54},"100631109","median-and-ulnar-nerve-function-in-tattoo-artists-100631109","NCT07496398","Median and Ulnar Nerve Function in Tattoo Artists","Occupational Hand-Arm Vibration Exposure and Its Effects on Median and Ulnar Nerve Function in Tattoo Artists: A Case-Control Study","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Professional tattoo artists with at least 1 year of occupational experience (case group)\n* Healthy individuals without occupational vibration exposure (control group)\n* Voluntary participation and provision of informed consent\n* No upper extremity trauma or surgery within the last 6 months\n\nExclusion Criteria:\n\n* Diagnosis of diabetes mellitus\n* Diagnosis of peripheral neuropathy\n* History of cervical radiculopathy or cervical disc herniation\n* History of upper extremity surgery or injury\n* Presence of rheumatologic or systemic inflammatory diseases\n* Pregnancy\n* Substance or alcohol abuse\n* Engagement in a second occupation involving repetitive hand use or vibration exposure",{"count":521,"type":23},20,"This case-control study aims to investigate the effects of occupational hand-arm vibration exposure on median and ulnar nerve functions in tattoo artists. Chronic exposure to vibration generated by tattoo machines may lead to neurosensory impairment, reduced tactile sensitivity, and decreased hand strength. Objective assessments including nerve provocation tests, sensory threshold evaluation, two-point discrimination, vibration perception, grip and pinch strength measurements, and validated patient-reported outcome questionnaires will be used. Findings will be compared with age- and sex-matched healthy controls.",[524,525,526],"Peripheral Neuropathy Pain","Carpal Tunnel Syndrome (CTS)","Cubital Tunnel Syndrome","2026-03-23",{"date":509,"type":46},{"date":530,"type":46},"2026-03-01",{"date":78,"type":23},{"name":52,"class":53},{"id":534,"slug":535,"hasResults":12,"nctId":536,"briefTitle":537,"officialTitle":538,"acronym":4,"eligibilityCriteria":539,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":540,"targetDuration":4,"studyType":24,"phases":541,"briefSummary":542,"conditions":543,"keywords":548,"overallStatus":174,"whyStopped":4,"lastUpdateSubmitDate":556,"lastUpdatePostDateStruct":557,"startDateStruct":559,"completionDateStruct":560,"leadSponsor":562,"locationsCount":54},"100630826","effect-of-visual-biofeedback-assisted-oropharyngeal-exercises-in-post-stroke-dysphagia-100630826","NCT07492719","Effect of Visual Biofeedback-Assisted Oropharyngeal Exercises in Post-Stroke Dysphagia","Effectiveness of Visual Biofeedback-Assisted Oropharyngeal Exercises Combined With Neuromuscular Electrical Stimulation in Patients With Post-Stroke Dysphagia: A Randomized Controlled Clinical Trial","Inclusion Criteria:\n\n* Adults aged 18 years or older\n* Clinical diagnosis of dysphagia, defined by at least one of the following: presence of cough or throat clearing during the 90 mL water swallow test, reduced laryngeal elevation on clinical examination, or at least one symptom related to dysphagia\n* Ability to initiate reflex swallowing\n* History of cerebrovascular event within the previous 6 months\n* Stable vital signs\n* Ability and willingness to provide written informed consent\n\nExclusion Criteria:\n\n* Severe cognitive impairment (Mini-Mental State Examination \\[MMSE\\] score \\\u003C 20), dementia, or severe communication difficulties due to aphasia\n* Contraindications to electrical stimulation, including the presence of an\n* implantable cardioverter-defibrillator (ICD), impaired skin integrity or open wounds at the electrode placement site, or active epilepsy\n* History of cervical surgery or presence of respiratory distress\n* Diagnosis of malignancy",{"count":282,"type":23},[26],"Post-stroke dysphagia is a common complication that negatively affects nutritional status, quality of life, and morbidity. Conventional swallowing rehabilitation, including oropharyngeal exercises and neuromuscular electrical stimulation (NMES), is widely used to improve swallowing function. This randomized controlled clinical study aims to investigate the effectiveness of visual biofeedback-assisted oropharyngeal exercises combined with NMES in patients with post-stroke dysphagia. Participants will be randomly assigned to either a visual biofeedback-assisted exercise group or a conventional exercise group, with both groups receiving NMES. Treatment will be administered five days per week for four weeks. Changes in swallowing function, suprahyoid muscle activity assessed by surface electromyography, and muscle stiffness evaluated by shear wave elastography will be analyzed to determine the effectiveness of the intervention.",[544,545,546,547],"Dysphagia After Stroke","Stroke","Dysphagia","Swallowing Disorders",[549,550,551,552,553,554,555],"Post-Stroke Dysphagia","Swallowing Rehabilitation","Oropharyngeal Exercises","Neuromuscular Electrical Stimulation (NMES)","Visual Biofeedback","Surface Electromyography (sEMG)","Shear Wave Elastography","2026-03-19",{"date":558,"type":46},"2026-03-25",{"date":297,"type":46},{"date":561,"type":23},"2028-01",{"name":52,"class":53},{"id":564,"slug":565,"hasResults":12,"nctId":566,"briefTitle":567,"officialTitle":568,"acronym":4,"eligibilityCriteria":569,"healthyVolunteers":156,"sex":18,"minAge":19,"maxAge":570,"enrollmentInfo":571,"targetDuration":4,"studyType":24,"phases":572,"briefSummary":573,"conditions":574,"keywords":577,"overallStatus":174,"whyStopped":4,"lastUpdateSubmitDate":581,"lastUpdatePostDateStruct":582,"startDateStruct":584,"completionDateStruct":585,"leadSponsor":587,"locationsCount":54},"100629185","adjunctive-keratinized-mucosa-augmentation-in-peri-implantitis-100629185","NCT07471386","Adjunctive Keratinized Mucosa Augmentation in Peri-Implantitis","Impact of Keratinized Mucosa Augmentation as an Adjunct to Non-Surgical Therapy in the Management of Peri-Implantitis","Inclusion Criteria:\n\n* Non-smoker\n* Systemically healthy\n* Keratinized mucosa witdh \\\u003C 2 mm\n\nExclusion Criteria:\n\n* İntake of medications that impede periodontal tissue health and healing\n* Pregnancy or lactation","75 Years",{"count":22,"type":23},[26],"This study aims to increase the width and thickness of peri-implant keratinized mucosa (KM) by transferring a properly dimensioned free gingival graft (FGG) from the palatal donor site and to evaluate its effect as an adjunctive approach to non-surgical peri-implantitis therapy. The procedure is indicated for patients diagnosed with peri-implantitis who present with an inadequate KM (midbuccal KM height \\\u003C 2 mm). One month after non-surgical therapy, patients in the test group will undergo keratinized mucosa augmentation using an FGG, while patients in the control group will continue with supportive periodontal therapy and regular follow-up visits. The primary outcome measure of the study is the change in probing depth (PD) at 12 months following peri-implantitis treatment.",[575,576],"Peri-implantitis","Soft Tissue Augmentation at Dental Implants",[575,578,579,580],"Free gingival graft","Inflamation","Soft tissue deficiency","2026-03-10",{"date":583,"type":46},"2026-03-13",{"date":530,"type":46},{"date":586,"type":23},"2027-06-01",{"name":52,"class":53},{"id":589,"slug":590,"hasResults":12,"nctId":591,"briefTitle":592,"officialTitle":592,"acronym":4,"eligibilityCriteria":593,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":331,"enrollmentInfo":594,"targetDuration":4,"studyType":24,"phases":596,"briefSummary":597,"conditions":598,"keywords":599,"overallStatus":174,"whyStopped":4,"lastUpdateSubmitDate":602,"lastUpdatePostDateStruct":603,"startDateStruct":605,"completionDateStruct":607,"leadSponsor":608,"locationsCount":54},"100625863","investigation-of-the-effects-of-task-oriented-circuit-training-on-upper-extremity-motor-function-in-stroke-patients-100625863","NCT07428161","Investigation of the Effects of Task-Oriented Circuit Training on Upper Extremity Motor Function in Stroke Patients","Inclusion Criteria:\n\n* Having received a stroke diagnosis for the first time\n* Having received a stroke diagnosis at least 1 month ago\n* Being between 18-65 years of age\n\nExclusion Criteria:\n\n* Having the following degree of active joint movement in the wrist and fingers (These conditions are necessary for patients to have the minimum hand dexterity to perform TOCT exercises)\n* At least 20° extension starting from full flexion in the wrist\n* At least 10° extension or abduction in the thumb\n* At least 10° extension in the metacarpophalangeal and interphalangeal joints of the other fingers",{"count":595,"type":23},24,[26],"Stroke is a disease characterized by symptoms such as weakness on one side of the body, speech impairment or inability to understand spoken language, vision problems, and loss of balance, walking, and coordination, resulting from a disruption in cerebral circulation that prevents oxygenation and nourishment of brain tissue. Currently, treatment approaches that adopt motor learning principles after stroke are fundamentally based on motor learning, neural plasticity, biomechanics, and the systems model of motor control. Task-Oriented Training (TOT), one of these treatment approaches, is used in the physiotherapy process for neurological diseases, and there is significant clinical evidence regarding the benefits of TOT. While the effects of TOT in physiotherapy have been primarily studied on balance and walking, there are a limited number of studies examining its effects on upper extremity function. Task-Oriented Circuit Training (TOCT) is a task-oriented training program consisting of 15 exercise stations where task-oriented training is applied in the form of exercise stations. TOCT improved upper extremity skills in Parkinson's patients. However, no study examines its effects on stroke. Therefore, this study aims to examine the effects of TOCT on upper extremity motor functions and dual-task performance in stroke patients.",[545],[545,600,601],"Task Oriented Circuit Training","Manual dexterity","2026-02-23",{"date":604,"type":46},"2026-02-25",{"date":606,"type":46},"2026-01-13",{"date":293,"type":23},{"name":52,"class":53},{"id":610,"slug":611,"hasResults":12,"nctId":612,"briefTitle":613,"officialTitle":614,"acronym":615,"eligibilityCriteria":616,"healthyVolunteers":12,"sex":18,"minAge":492,"maxAge":4,"enrollmentInfo":617,"targetDuration":4,"studyType":24,"phases":619,"briefSummary":620,"conditions":621,"keywords":623,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":626,"lastUpdatePostDateStruct":627,"startDateStruct":629,"completionDateStruct":630,"leadSponsor":631,"locationsCount":4},"100625634","effect-of-word-search-and-case-based-puzzle-use-in-stoma-care-education-of-nursing-students-100625634","NCT07425184","Effect of Word Search and Case-Based Puzzle Use in Stoma Care Education of Nursing Students","The Effect of Using Word Searches and Case-Based Puzzles in Stoma Care Education for Nursing Students","PUZZLE-STOMA","Inclusion Criteria:\n\n* Nursing students enrolled in the Surgical Nursing course for the first time,\n* Students who voluntarily agree to participate in the study.\n\nExclusion Criteria:\n\n* Students who have previously received stoma care training through another educational platform,\n* Students who provide incomplete responses to data collection forms,\n* Students who do not attend the theoretical course sessions,\n* Students who do not participate in any stage of the knowledge assessment,\n* Students who do not complete puzzle and word search activities included in the intervention.",{"count":618,"type":23},87,[26],"Objective: This study aims to determine the effect of using word search and case-based puzzles in stoma care education on nursing students' knowledge levels. Given that traditional teaching methods may have limited effectiveness in helping students acquire knowledge and skills, the study aims to demonstrate the contribution of integrating active learning and gamification-based approaches into education.\n\nDesign: The study is planned as a randomized controlled experimental design and will use a pre-test-post-test measurement approach.\n\nMethod: The study will be conducted with second-year students from the Nursing Department at Gazi University. This research will be prepared under the guidance of the Standard Protocol Items: Recommendations for Interventional Trials (SPIRIT) protocol, and the reporting of the randomized controlled study will be carried out under the Consolidated Standards of Reporting Trials (CONSORT). In the study, students will be randomly assigned to the experimental and control groups. The experimental group will receive training that includes word search and case-based puzzles during the stoma care training process, while the control group will receive training using traditional teaching methods. Students' knowledge levels will be assessed with measurements applied before and after the training, and student opinions regarding the training method will also be analyzed. The \"Stoma Care Knowledge Level Assessment Test\" will be used to evaluate knowledge levels, and the \"Student Opinions on the Use of Puzzles and Word Searches in Stoma Education\" form will be used to determine student opinions.\n\nHypothesis: The null hypothesis (H0) of the study states that the use of word search and case-based puzzles in stoma care education has no effect on students' knowledge level; the alternative hypothesis (H1) states that this educational method significantly affects students' knowledge level.",[622,445,498],"Ostomy",[445,624,504,625],"Case-Based Learning","Puzzle-Based Learning","2026-02-13",{"date":628,"type":46},"2026-02-20",{"date":297,"type":23},{"date":556,"type":23},{"name":52,"class":53},{"id":633,"slug":634,"hasResults":12,"nctId":635,"briefTitle":636,"officialTitle":637,"acronym":4,"eligibilityCriteria":638,"healthyVolunteers":156,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":639,"targetDuration":4,"studyType":64,"phases":4,"briefSummary":641,"conditions":642,"keywords":644,"overallStatus":174,"whyStopped":4,"lastUpdateSubmitDate":650,"lastUpdatePostDateStruct":651,"startDateStruct":653,"completionDateStruct":655,"leadSponsor":656,"locationsCount":54},"100623312","assessment-of-exercise-capacity-muscle-oxygenation-and-aortic-stiffness-in-patients-with-mitral-stenosis-100623312","NCT07394998","Assessment of Exercise Capacity, Muscle Oxygenation and Aortic Stiffness in Patients With Mitral Stenosis","Comparison of Exercise Capacity, Muscle Oxygenation and Aortic Stiffness in Patients With a History of Mitral Valve Intervention for Mitral Stenosis With Healthy Subjects","Inclusion Criteria:\n\nPatients;\n\n* Between the ages of 18-80\n* Patients who have undergone mitral valve intervention due to mitral stenosis\n* At least 3 months have passed since the intervention\n\nHealthy controls;\n\n* Between the ages of 18 and 80\n* Agreeing to participate voluntarily in the study\n\nExclusion Criteria:\n\nPatients;\n\n* Patients who have undergone aortic valve intervention other than mitral valve intervention\n* Acute infection\n* Orthopedic, neurological or psychological disorders that will affect functional capacity\n\nHealthy Controls;\n\n* diagnosed chronic disease,\n* acute infection\n* A smoking history of at least 10 packs×years or more",{"count":640,"type":23},40,"Heart valve diseases are the most common cause of mortality and morbidity after coronary artery disease, hypertension, and heart failure. In patients with mitral stenosis, the narrowed valve restricts blood flow, causing symptoms such as shortness of breath, fatigue, exertional dyspnea, orthopnea, and paroxysmal nocturnal dyspnea. These patients may experience decreased exercise capacity and physical activity levels, deterioration in quality of life, and deterioration in respiratory function. When reviewing the literature, we see that the study groups evaluating these factors are generally not homogeneous, and most studies conducted in patients with mitral stenosis evaluate patients who have undergone percutaneous mitral balloon valvuloplasty.",[643],"Mitral Stenosis",[645,646,647,648,649],"cardiopulmonary exercise test","aortic stiffness","muscle oxygenation","physical activity","mitral stenosis","2026-01-31",{"date":652,"type":46},"2026-02-06",{"date":654,"type":46},"2025-01-13",{"date":48,"type":23},{"name":52,"class":53},{"id":658,"slug":659,"hasResults":12,"nctId":660,"briefTitle":661,"officialTitle":662,"acronym":4,"eligibilityCriteria":663,"healthyVolunteers":12,"sex":18,"minAge":664,"maxAge":665,"enrollmentInfo":666,"targetDuration":4,"studyType":24,"phases":668,"briefSummary":669,"conditions":670,"keywords":672,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":650,"lastUpdatePostDateStruct":676,"startDateStruct":678,"completionDateStruct":680,"leadSponsor":682,"locationsCount":4},"100622812","interactive-digital-art-based-relaxation-program-100622812","NCT07388485","Interactive Digital Art-Based Relaxation Program","The Effect of an Interactive Digital Art-Based Relaxation Program on Physiological Parameters, Anxiety, and Emotional Distress in Children Receiving Treatment in the Pediatric Intensive Care Unit: A Randomized Controlled Trial","Inclusion Criteria:\n\n* • Be between 7 and 12 years of age\n\n  * Be conscious and able to respond to commands\n  * Not be receiving sedative\u002Fanalgesic infusion or be at minimal sedation level (RASS ≥ -1)\n  * Have been monitored in intensive care for at least 24 hours\n  * Have stable vital signs\n  * Have no visual or auditory perception loss\n  * Parental consent and verbal consent from the child must have been obtained\n\nExclusion Criteria:\n\n* Severe neurological deficit or motor impairment\n\n  * Severe pain, delirium, or agitation\n  * Severe psychiatric diagnosis or requirement for high-dose sedation\n  * Being in the terminal phase","7 Years","12 Years",{"count":667,"type":23},60,[26],"This randomized controlled trial aims to evaluate the effects of an Interactive Digital Art-Based Relaxation Program on physiological parameters, anxiety levels, and emotional distress in children aged 7-12 years receiving care in a pediatric intensive care unit (PICU). Children in the intervention group will receive three short, nurse-guided digital art-based relaxation sessions delivered via tablet, while the control group will receive standard PICU nursing care. Outcomes will be assessed using physiological measurements and validated psychological assessment tools before and after the intervention.",[671,341],"Pediatric Critical Illness",[673,674,675],"Pediatric Intensive Care Unit","Children","Interactive Digital Art-Based Relaxation",{"date":677,"type":46},"2026-02-05",{"date":679,"type":23},"2026-01-20",{"date":681,"type":23},"2027-03-20",{"name":52,"class":53},{"id":684,"slug":685,"hasResults":12,"nctId":686,"briefTitle":687,"officialTitle":688,"acronym":4,"eligibilityCriteria":689,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":570,"enrollmentInfo":690,"targetDuration":4,"studyType":24,"phases":691,"briefSummary":692,"conditions":693,"keywords":695,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":650,"lastUpdatePostDateStruct":700,"startDateStruct":702,"completionDateStruct":704,"leadSponsor":706,"locationsCount":54},"100617192","acute-hemodynamic-responses-to-blood-flow-restriction-aerobic-exercise-in-interstitial-lung-disease-100617192","NCT07315425","Acute Hemodynamic Responses to Blood Flow Restriction Aerobic Exercise in Interstitial Lung Disease","Investigation of the Acute Effects of Blood Flow Restriction Aerobic Exercise on Hemodynamic Responses and Muscle Oxygen in Patients With Interstitial Lung Disease","Inclusion Criteria:\n\n* Diagnosis of interstitial lung disease according to the European Respiratory Society (ERS) and American Thoracic Society (ATS) diagnostic criteria.\n* Willingness to participate in the study and provide written informed consent.\n\nExclusion Criteria:\n\n* Presence of any acute infection at the time of the study.\n* Orthopedic or neurological conditions that may affect exercise capacity.\n* Contraindications to exercise testing according to the American College of Sports Medicine (ACSM) guidelines.\n* History of COVID-19 infection within the last three months.\n* Receiving treatments outside standard medical therapy.\n* Presence of peripheral arterial disease.\n* Presence of peripheral neuropathy.\n* Resting blood pressure greater than 160\u002F100 mmHg.\n* History of deep vein thrombosis, pulmonary embolism, or stroke.",{"count":22,"type":23},[26],"Interstitial lung diseases (ILD)impaired gas exchange and reduced lung elasticity lead to marked reductions in exercise capacity and decreased oxygen consumption due to circulatory limitations. Blood flow restriction (BFR) exercise involves applying external pressure to partially restrict venous return without entirely blocking arterial inflow. This controlled compression induces temporary hypoxic and metabolic stress, triggering high-intensity-like responses that stimulate growth hormone release, increase protein synthesis, and promote muscle hypertrophy. However, the most crucial advantage of blood flow restriction during exercise is its ability to increase muscle mass during aerobic training. IIn individuals with ILD, BFR may offer a safe and practical way to improve muscle mass and exercise capacity with minimal additional strain on the cardiovascular and musculoskeletal systems.Our study aimed to compare the acute effects of low-intensity blood flow restriction aerobic exercise training and low-intensity aerobic exercise training on hemodynamic responses and muscle oxygenation in patients with ILD. Method: 30 patients with a diagnosis of ILD being followed up will be included in the study. Our study was a randomized, crossover, triple-blind, prospective study. Assessments will be performed at the beginning of the study. On the first day, demographic data and clinical findings of the individuals will be collected. Patients will be asked questions, and their responses will be recorded in their medical records. Respiratory function, respiratory muscle strength and endurance, and peripheral muscle strength will be evaluated. 48 hours from the first day, patients' maximal exercise capacity will be assessed with a cardiopulmonary exercise test (CPET), and muscle oxygenation during CPET will be assessed with a Moxy® monitor. Respiratory muscle fatigue will be assessed with an oral pressure monitor before and after the exercise test. The assessments will be completed over two days. One week after the evaluations, patients will be randomly assigned to two groups. One group will receive low-intensity aerobic exercise training, and the other will receive low-intensity aerobic exercise training with blood flow restriction. Muscle oxygenation will be assessed during both exercise sessions, and respiratory muscle fatigue will be measured before and after each session. All participants will receive both exercise sessions.",[694],"Interstitial Lung Disease (ILD)",[696,697,698,699],"Blood Flow Restriction","Interstitial Lung Disease","Muscle Oxygenation","Aerobic Exercise",{"date":701,"type":46},"2026-02-03",{"date":703,"type":23},"2026-02",{"date":705,"type":23},"2028-12",{"name":52,"class":53},""]