[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Gelderse Vallei Hospital\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":102},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,45,72],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":27,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100606280","the-effect-of-continuous-versus-intermittent-enteral-nutrition-on-metabolic-outcomes-in-critically-ill-patients-100606280",false,"NCT07173504","The Effect of Continuous Versus Intermittent Enteral Nutrition on Metabolic Outcomes in Critically Ill Patients","CONVEnIENT","Inclusion Criteria:\n\n1. Age ≥18 years;\n2. Receiving or eligible to receive exclusively gastric tube feeding;\n3. Expected ICU stay ≥48 hours;\n4. Receiving or anticipated to receive invasive mechanical ventilation within 48 hours after ICU admission.\n\nExclusion Criteria:\n\n1. The treating clinician considers participation in the study clinically contraindicated (e.g., change in feeding regimen, no possibility for placement of CGM on arms, not able to receive exclusive gastric tube feeding);\n2. Death is deemed to be imminent or inevitable during admission, and the attending doctor, patient, or substitute decision-maker is not committed to active treatment;\n3. Pregnancy;\n4. Expected fasting for ≥12 hours during the study period, for example, due to medical procedures;\n5. Readmission in last 14 days;\n6. Patients with burn injuries;\n7. Participating in another nutritional intervention study.","ALL","18 Years",{"count":19,"type":20},124,"ESTIMATED","INTERVENTIONAL",[23],"NA","The goal of this clinical trial is to investigate the effect of continuous versus intermittent enteral nutrition on metabolic outcomes in critically ill adult patients.\n\nThe aim of this study is to:\n\n• To assess the effect of a daytime intermittent tube feeding pattern compared to standard continuous tube feeding on glycaemic control, gastrointestinal function, gastrointestinal hormones, markers of sleep quality and circadian rhythm, and lean body mass and body composition.\n\nParticipants will receive either continuous enteral nutrition for 24 hours a day or intermittent enteral nutrition during the day, consisting of 4 portions each administered over 1 hour between 8 am and 8 pm. The maximum duration of the intervention is 5 days or until participants do not receive exclusive gastric enteral nutrition.",[26],"Critical Illness",[28,29,30,31],"critical illness","tube feeding","glycemic control","chrononutrition","RECRUITING","2026-03-11",{"date":35,"type":36},"2026-03-13","ACTUAL",{"date":38,"type":36},"2025-09-30",{"date":40,"type":20},"2028-09",{"name":42,"class":43},"Gelderse Vallei Hospital","OTHER",5,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":4,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":52,"targetDuration":54,"studyType":55,"phases":4,"briefSummary":56,"conditions":57,"keywords":58,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":71},"100616983","protein-dosing-strategies-in-critically-ill-patients-comparing-actual-body-weight-and-fat-free-mass-approaches-in-an-observational-cohort-study-100616983","NCT07312708","Protein Dosing Strategies in Critically Ill Patients: Comparing Actual Body Weight and Fat-Free Mass Approaches in an Observational Cohort Study","LEan Body Mass Development in CriTically Ill Patients, Obtained by bioelectRical impEdance Analysis: a Combined Retrospective and Prospective Observational Cohort Study","Inclusion Criteria:\n\n* ≥18 years old\n* a BIA measurement available within 48 hours after ICU admission\n* at least one follow-up BIA measurement during ICU stay.\n\nExclusion Criteria:\n\n* transfer from another ICU resulting in the first BIA measurement \\>48 hours after admission to GVH\n* a previous ICU admission within 2 weeks before the current admission.",{"count":53,"type":20},620,"90 Days","OBSERVATIONAL","This study investigates how different methods of calculating protein intake affect recovery and muscle preservation in critically ill patients in the Intensive Care Unit (ICU). Protein is essential for maintaining muscle strength, supporting healing, and improving recovery during critical illness.\n\nAt Hospital Gelderse Vallei, patients admitted to the ICU received protein based on actual body weight until 2023; more recently, protein prescriptions have been based on fat-free mass. Bioelectrical impedance analysis (BIA) has been part of standard clinical practice in the ICU since April 2020, meaning that all patients admitted since then have been screened for inclusion in the study.\n\nThis design allows for comparison between two groups: one group receiving protein based on actual body weight according to current clinical guidelines (1.5 g\u002Fkg body weight), and another group whose protein intake is calculated based on lean body mass (LBM) measured by BIA. BIA measurements are repeated during the ICU stay to monitor changes in body composition.\n\nA total of 310 patients admitted to the ICU between the start of BIA implementation in April 2020 and the transition to fat-free mass-based dosing in 2023 were identified. To allow for balanced comparison, an equal number of 310 patients from the subsequent period, in which protein dosing was based on fat-free mass, were included in the study.\n\nThe study compares these two groups to determine whether calculating protein requirements based on lean body mass leads to better clinical outcomes-such as improved recovery (lower mortality and shorter hospital stay), preservation of muscle mass, and lower UCR-than the traditional method based on actual body weight. The data analysis plan was established prior to completion of patient inclusion and database lock.",[26],[59,28,60,61,62],"proteins","lean body mass","fat free mass","BIA","2025-12-17",{"date":65,"type":36},"2025-12-31",{"date":67,"type":36},"2020-04-01",{"date":69,"type":20},"2026-02-01",{"name":42,"class":43},1,{"id":73,"slug":74,"hasResults":11,"nctId":75,"briefTitle":76,"officialTitle":77,"acronym":78,"eligibilityCriteria":79,"healthyVolunteers":80,"sex":16,"minAge":81,"maxAge":82,"enrollmentInfo":83,"targetDuration":4,"studyType":21,"phases":85,"briefSummary":86,"conditions":87,"keywords":89,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":71},"100470540","effect-of-collagenvitamin-c-in-jumpers-knee-a-rct-100470540","NCT05407194","Effect of Collagen\u002FVitamin C in Jumper's Knee; a RCT","Additional Effect of Collagen\u002FVitamin C in Exercise Treatment for Patellar Tendinopathy (Jumper's Knee); a Randomized Controlled Trial","Jumpfood","Inclusion Criteria:\n\n* Age 16 - 40 years old (the chosen age range will minimize chances of other conditions causing anterior knee pain such as osteoarthritis among patients above 40 years and osteochondrotic diseases like Sinding-Larsen-Johansson syndrome and Osgood-Schlatter disease among patients below the age of 16).\n* History of focal knee pain in patellar tendon or its patellar or tibial insertion in association with training and\u002For competition.\n* Current symptom duration of at least 12 weeks.\n* Sports participation at least once a week for at least one year.\n* Palpation tenderness to the corresponding painful area on the patellar tendon.\n* Focal patellar tendon pain during patellar tendon loading with a pain provocation test (single leg decline squat and\u002For single leg jump squat)\n* Victorian Institute of Sports Assessment (VISA-P) score \\\u003C 80 out of 100 points.\n* Willingness to take (non-vegetarian) nutritional supplements.\n\nExclusion Criteria:\n\n* Known presence of inflammatory joint diseases (e.g. spondylarthropathy, gout or rheumatoid arthritis) or familial hypercholesterolaemia.\n* Daily use of drugs with a putative effect on the patellar tendon in the preceding year (e.g. fluoroquinolones and statins)\n* Knee surgery without a full completion of the rehabilitation program in the history of the index knee\n* Previous patellar tendon rupture of the index knee\n* Local injection therapy with corticosteroids, other drugs, blood, platelet rich plasma or stem cells in the preceding 12 months\n* Acute knee injuries, including patellar tendon injuries with an acute onset\n* Inability to perform the PTLE program\n* Participation in other concomitant treatment programs\n* Signs or symptoms of other coexisting knee pathology on physical examination (such as patellofemoral pain syndrome, joint effusion and joint line tenderness) or additional diagnostics when found necessary by the sports physician (Chondral lesion of the patella or trochlea on MRI or prepatellar bursitis on US).\n* Already using collagen supplementation\n* Giving blood donation in a period of two months prior to each test day\n* Being pregnant or wish to become pregnant in the upcoming year\n* Abuse of hard drugs\n* An alcohol consumption \\>21 units\u002Fweek (men) or \\>14 units\u002Fweek (women)",true,"16 Years","40 Years",{"count":84,"type":20},76,[23],"Patellar tendinopathy (PT) is a tendon overuse injury with high prevalence rates in elite and recreational athletes. PT sometimes results in a prolonged absence from sport participation, hampering individuals to achieve their desired performance levels and to benefit from the health related effects of sports participation. Many treatment options are used but management of PT remains challenging. Current treatment involves progressive education, load management and tendon loading exercises (PTLE). Recent studies have shown that nutrition can positively affect collagen synthesis in musculoskeletal tissues. A study showed that supplementing 15g of gelatine combined with 50mg of Vitamin C, 1 hour before loading exercises, resulted in an increase in whole body collagen synthesis and increased mechanics and collagen content of human engineered ligaments. However the effectiveness of oral supplementation of hydrolysed collagen in combination with vitamin C in athletes with PT has not been studied in a randomized controlled trial yet.\n\nObjective: The primary aim of this RCT is to evaluate whether the use of oral supplementation of hydrolysed collagen\u002Fvitamin C in addition to usual care (education, load management and PTLE) is superior to usual care and placebo on VISA-P score after 12, 24 and 52 weeks for athletes with PT. The secondary aim of this RCT is to evaluate whether the use of oral supplementation of hydrolysed collagen\u002Fvitamin C in addition to usual care (education, load management and PTLE) is superior to usual care and placebo on other clinical outcome parameters, functional tests and tendon structure after 12 and 24 weeks for athletes with PT.",[88],"Patellar Tendinopathy",[90,91,92,93],"collagen","progressive tendon loading therapy","gelatin","RCT","2024-09-24",{"date":96,"type":36},"2024-09-26",{"date":98,"type":36},"2023-04-01",{"date":100,"type":20},"2026-05-01",{"name":42,"class":43},""]