[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Genesis Athens Clinic\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":121},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,55,80,104],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":28,"conditions":29,"keywords":36,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":43,"lastUpdatePostDateStruct":44,"startDateStruct":47,"completionDateStruct":49,"leadSponsor":51,"locationsCount":54},"100453223","phase-2-autologous-platelet-rich-plasma-intraovarian-infusion-for-poor-responders-100453223",false,"NCT05181748","Autologous Platelet Rich Plasma Intraovarian Infusion for Poor Responders","Investigating the Efficiency of Autologous Platelet Rich Plasma Intraovarian Infusion on Improving Ovarian Functionality in Poor Ovarian Response Patients","PRPPOR","Inclusion Criteria:\n\nPoor Ovarian Response according to Bologna Criteria (fulfilling 2 out of 3 of the following):\n\n1. Age ≥ 40 years\n2. AMH \\\u003C 1.1 ng\u002Fml OR AFC \\\u003C 7\n3. ≤ 3 oocytes with a conventional stimulation protocol\n\n   * Discontinuation of any complementary\u002Fadjuvant treatment including hormone replacement and acupuncture, for at least three months prior to recruitment.\n   * Willing to comply with study requirements\n\nExclusion Criteria:\n\n* Any pathological disorder related to reproductive system anatomy\n* Cycle irregularities\n* Amenorrhea\n* Endometriosis\n* Adenomyosis\n* Fibroids and adhesions\n* Infections in reproductive system\n* Current or previous diagnosis of cancer in reproductive system\n* History of familiar cancer in reproductive system\n* Severe male factor infertility\n* Prior referral for Preimplantation Genetic Testing (PGT) -Ovarian inaccessibility -Endocrinological disorders (Hypothalamus-\n* Pituitary disorders, thyroid dysfunction, diabetes mellitus, metabolic syndrome)\n* BMI\\>30 kg\u002Fm2 or BMI\\\u003C18.5 kg\u002Fm2\n* Systematic autoimmune disorders",true,"FEMALE","35 Years","47 Years",{"count":22,"type":23},100,"ESTIMATED","INTERVENTIONAL",[26,27],"PHASE2","PHASE3","Autologous platelet rich plasma (PRP) intraovarian infusion may improve ovarian response to controlled ovarian stimulation as well as the hormonal profile of poor ovarian response infertile women subjected to intracytoplasmic sperm injection (ICSI) treatment.",[30,31,32,33,34,35],"Poor Response to Ovulation Induction","Infertility, Female","Ovarian Insufficiency","Ovarian Failure","Reproductive Sterility","Ovary; Anomaly",[37,38,39,40,41],"Autologous platelet rich plasma intraovarian infusion","Assisted reproduction","PRP","In vitro fertilization","Ovarian functionality improvement","RECRUITING","2024-12-20",{"date":45,"type":46},"2024-12-27","ACTUAL",{"date":48,"type":46},"2019-01-23",{"date":50,"type":23},"2026-01-31",{"name":52,"class":53},"Genesis Athens Clinic","OTHER",1,{"id":56,"slug":57,"hasResults":11,"nctId":58,"briefTitle":59,"officialTitle":60,"acronym":39,"eligibilityCriteria":61,"healthyVolunteers":17,"sex":18,"minAge":62,"maxAge":63,"enrollmentInfo":64,"targetDuration":4,"studyType":24,"phases":65,"briefSummary":66,"conditions":67,"keywords":4,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":43,"lastUpdatePostDateStruct":73,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":54},"100364916","phase-2-autologous-prp-infusion-may-restore-ovarian-function-and-may-promote-folliculogenesis-in-poi-patients-100364916","NCT04031456","Autologous PRP Infusion May Restore Ovarian Function and May Promote Folliculogenesis in POI Patients","Investigating Reactivation of Ovarian Function Following Autologous PRP Intra-ovarian Infusion in POI Patients","Inclusion Criteria:\n\n* Age \\\u003C 40 years, presenting with amenorrhea or menstrual cycle irregularities for at least four months, and elevated FSH levels \\>25 IU\u002FL recorded on two occasions \\>4 weeks apart\n* Normal Karyotype: 46, XX\n* Discontinuation of any complementary\u002Fadjuvant treatment including hormone replacement, acupuncture, and botanotherapy, for at least three months prior to recruitment.\n* Willing to comply with study requirements\n\nExclusion Criteria:\n\n* Any pathological disorder related to reproductive system anatomy\n* AMH \\> 8 pmol\u002FL\n* Endometriosis\n* Adenomyosis\n* Fibroids and adhesions\n* Infections in reproductive system\n* Current or previous diagnosis of cancer in reproductive system\n* History of familiar cancer in reproductive system\n* Severe male factor infertility\n* Prior referral for PGT\n* Ovarian inaccessibility\n* Endocrinological disorders (Hypothalamus-Pituitary disorders, thyroid dysfunction, diabetes mellitus, metabolic syndrome)\n* BMI\\>30 kg\u002Fm2 or BMI\\\u003C18.5 kg\u002Fm2\n* Systematic autoimmune disorders","25 Years","39 Years",{"count":22,"type":23},[26,27],"Autologous PRP intra ovarian infusion may restore ovarian function, may promote folliculogenesis and may improve patients' hormonal profile in patients presenting with POI.",[68,69,70,71,72],"Menopause, Premature","Menopause Related Conditions","Menopausal Syndrome","Premature Ovarian Failure","Ovarian Failure, Premature",{"date":74,"type":46},"2024-12-24",{"date":76,"type":46},"2019-07-30",{"date":78,"type":23},"2026-07-30",{"name":52,"class":53},{"id":81,"slug":82,"hasResults":11,"nctId":83,"briefTitle":84,"officialTitle":85,"acronym":39,"eligibilityCriteria":86,"healthyVolunteers":17,"sex":18,"minAge":87,"maxAge":88,"enrollmentInfo":89,"targetDuration":4,"studyType":24,"phases":90,"briefSummary":91,"conditions":92,"keywords":96,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":43,"lastUpdatePostDateStruct":99,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":103,"locationsCount":54},"100356129","phase-2-autologous-prp-intra-ovarian-infusion-to-restore-ovarian-function-in-menopausal-women-100356129","NCT03916978","Autologous PRP Intra Ovarian Infusion to Restore Ovarian Function in Menopausal Women","Investigating Reactivation of Ovarian Function Following Autologous PRP Intra-ovarian Infusion in Menopausal Women","Inclusion Criteria:\n\n* Age between 45-55 years old\n* Amenorrhea for at least 12 months\n* Discontinuation of any complementary\u002Fadjuvant treatment including hormone replacement, acupuncture, and botanotherapy, for at least three months prior to recruitment.\n* Willing to comply with study requirements\n\nExclusion Criteria:\n\n* Any pathological disorder related to reproductive system anatomy\n* Previous POI diagnosis\n* Abnormal karyotype\n* Endometriosis\n* Adenomyosis\n* Fibroids and adhesions\n* Infections in reproductive system\n* Current or previous diagnosis of reproductive system cancer\n* History of familiar cancer in reproductive system\n* Severe male factor infertility\n* Prior referral for PGT\n* Ovarian inaccessibility\n* Endocrinological disorders (Hypothalamus-Pituitary disorders, thyroid dysfunction, diabetes mellitus, metabolic syndrome)\n* BMI\\>30 kg\u002Fm2 or BMI\\\u003C18.5 kg\u002Fm2\n* Systematic autoimmune disorders","45 Years","55 Years",{"count":22,"type":23},[26,27],"Autologous PRP intra ovarian infusion may restore ovarian function, may promote folliculogenesis and may improve hormonal profile of women in menopause.",[31,93,94,95],"Anovulatory Infertility","Menopause","Amenorrhea",[97,98],"Ovarian rejuvenation","Ovarian reactivation; ovulation",{"date":45,"type":46},{"date":101,"type":46},"2019-05-21",{"date":78,"type":23},{"name":52,"class":53},{"id":105,"slug":106,"hasResults":11,"nctId":107,"briefTitle":108,"officialTitle":109,"acronym":39,"eligibilityCriteria":110,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":111,"targetDuration":4,"studyType":24,"phases":112,"briefSummary":113,"conditions":114,"keywords":4,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":43,"lastUpdatePostDateStruct":115,"startDateStruct":116,"completionDateStruct":118,"leadSponsor":120,"locationsCount":54},"100357715","phase-2-autologous-platelet-rich-plasma-intra-ovarian-infusion-in-poor-responders-100357715","NCT03937661","Autologous Platelet-Rich Plasma Intra-ovarian Infusion in Poor Responders","Investigating Improvement of Ovarian Function Following Autologous PRP Intra-ovarian Infusion in Poor Responders","Inclusion Criteria:\n\n* Poor Ovarian Response according to Bologna Criteria (fulfilling 2 out of 3 of the following)\n* Age ≥ 40 years\n* AMH \\\u003C 1.1 ng\u002Fml OR AFC \\\u003C 7\n* ≤ 3 oocytes with a conventional stimulation protocol)\n* Discontinuation of any complementary\u002Fadjuvant treatment including hormone replacement, acupuncture, and botanotherapy, for at least three months prior to recruitment.\n* Willing to comply with study requirements\n\nExclusion Criteria:\n\n* Any pathological disorder related to reproductive system anatomy\n* Cycle irregularities\n* Amenorrhea\n* Endometriosis\n* Adenomyosis\n* Fibroids and adhesions\n* Infections in reproductive system\n* Current or previous diagnosis of cancer in reproductive system\n* History of familiar cancer in reproductive system\n* Severe male factor infertility\n* Prior referral for PGT\n* Ovarian inaccessibility -Endocrinological disorders (Hypothalamus-\n* Pituitary disorders, thyroid dysfunction, diabetes mellitus, metabolic syndrome)\n* BMI\\>30 kg\u002Fm2 or BMI\\\u003C18.5 kg\u002Fm2\n* Systematic autoimmune disorders",{"count":22,"type":23},[26,27],"Autologous PRP intra ovarian infusion may improve ovarian response, patients' hormonal profile as well as fresh embryo transfer (ET)-ICSI cycles' outcome in patients presenting with Poor Ovarian Response (POR).",[35,31],{"date":45,"type":46},{"date":117,"type":46},"2019-05-06",{"date":119,"type":23},"2025-08-30",{"name":52,"class":53},""]