[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"George Emil Palade University of Medicine, Pharmacy, Sciences and Technology of Targu Mures\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":168},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,55,86,118,142],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":29,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":43,"lastUpdatePostDateStruct":44,"startDateStruct":47,"completionDateStruct":49,"leadSponsor":51,"locationsCount":54},"100642058","comparison-of-patient-reported-comfort-between-two-clear-aligner-trimming-line-designs-a-split-mouth-study-100642058",false,"NCT07660809","Comparison of Patient-Reported Comfort Between Two Clear Aligner Trimming-Line Designs: A Split-Mouth Study","Comparison of Patient-Reported Comfort Between Supragingival and Juxtagingival Clear Aligner Trimming-Line Designs: A Cross-Sectional, Within-Subject Split-Mouth Study","COMFORT-ALIGN","Inclusion Criteria:\n\n* Adolescent or adult patient (aged 15 years or older)\n* Active orthodontic treatment with clear aligners, including finishing (refinement) aligners\n* Wearing two clear aligners with different trimming-line designs, one per dental arch: a supragingival design on one arch and a juxtagingival design on the contralateral arch\n* At least 4 weeks of wear of the two designs at the time of questionnaire completion\n* Good treatment compliance\n* Willing and able to complete the online questionnaire and provide the required consent\n\nExclusion Criteria:\n\n* Mixed orthodontic treatment (aligners combined with fixed appliances)\n* Pre-existing neurological, cognitive, or speech disorders\n* Systemic conditions affecting the oral cavity (e.g., xerostomia, mucosal disorders)",true,"ALL","15 Years",{"count":21,"type":22},70,"ESTIMATED","OBSERVATIONAL","* The trimming-line design of clear aligners (supragingival versus juxtagingival) is a routine clinical decision whose influence on patient-reported comfort has not been established; available evidence on aligner comfort derives almost exclusively from comparisons with fixed appliances.\n* This observational, cross-sectional study compares two clear aligner trimming-line designs with respect to patient-reported comfort: a supragingival design, whose edge rests on the marginal gingiva, and a juxtagingival design, whose edge follows the gingival contour without covering it. Because the two designs sit differently against the gingival soft tissue, they may be experienced differently during wear.\n* Participants are patients already wearing one trimming-line design on one dental arch and the other on the contralateral arch; each participant thus serves as their own control. After a minimum of four weeks of wear, participants complete a 20-item questionnaire once, rating the frequency of defined oral experiences for the maxillary and mandibular arch separately on a three-point ordinal scale (0 = none, 1 = occasional, 2 = frequent).\n* The questionnaire is anonymous; the design worn on each arch is identified from which of two identical forms a participant completes. Responses for the two designs are compared within each participant. The study evaluates whether trimming-line design is associated with differences in patient-reported comfort.",[26,27,28],"Patient Comfort","Malocclusion","Oral Health",[30,31,32,33,34,35,36,37,38,39,40,41],"clear aligners","trimming-line design","gingival margin","supragingival","juxtagingival","split-mouth design","patient-reported outcome","comfort","oral health-related quality of life","questionnaire","orthodontics","finishing orthodontic treatment","NOT_YET_RECRUITING","2026-06-18",{"date":45,"type":46},"2026-06-23","ACTUAL",{"date":48,"type":22},"2026-07",{"date":50,"type":22},"2026-08",{"name":52,"class":53},"George Emil Palade University of Medicine, Pharmacy, Sciences and Technology of Targu Mures","OTHER",1,{"id":56,"slug":57,"hasResults":11,"nctId":58,"briefTitle":59,"officialTitle":60,"acronym":61,"eligibilityCriteria":62,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":63,"targetDuration":4,"studyType":65,"phases":66,"briefSummary":68,"conditions":69,"keywords":71,"overallStatus":78,"whyStopped":4,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":82,"completionDateStruct":83,"leadSponsor":85,"locationsCount":54},"100641544","effect-of-finishing-clear-aligner-marginal-termination-design-supragingival-vs-juxtagingival-on-aligner-color-stability-after-14-days-of-wear-a-split-mouth-study-100641544","NCT07628491","Effect of Finishing Clear Aligner Marginal Termination Design (Supragingival vs Juxtagingival) on Aligner Color Stability After 14 Days of Wear: A Split-Mouth Study","Colorimetric Stability of Finishing Clear Aligners According to Marginal Termination Design (Supragingival Versus Juxtagingival) After 14 Days of Intraoral Wear During Orthodontic Treatment: A Prospective Split-Mouth Study","SPECTRO-ALIGN","Inclusion Criteria:\n\n* Adolescent and adult patients (age 15 years or older at enrollment)\n* Undergoing a finishing (refinement) stage of clear aligner therapy, with only small residual tooth movements remaining, including both patients completing active orthodontic treatment and patients with prior orthodontic treatment who require additional refinement (e.g., minor relapse or loss of retention)\n* Adherence to the prescribed oral hygiene instructions\n* Written informed consent; for participants aged 15-17 years, written consent from a parent or legal guardian\n\nExclusion Criteria:\n\n* Deficient oral hygiene\n* Excessive consumption of intensely staining beverages (coffee, tea, red wine, colored carbonated drinks)\n* Systemic conditions or medications that may affect salivary secretion or tooth color\n* Non-compliance with the aligner \u002F orthodontic appliance wear protocol",{"count":64,"type":22},50,"INTERVENTIONAL",[67],"NA","* The goal of this clinical study is to learn whether the gumline edge design of a finishing orthodontic clear aligner affects how much the aligner's color changes after 14 days of wear.\n* The main question is: does a supragingival edge design - a straight edge covering about 2 mm of gum tissue - lead to a different amount of color change in the aligner compared with a juxtagingival edge design that follows the gumline exactly, after 14 days of wear?\n* Each participant wears finishing clear aligners with both edge designs at the same time - one design on the upper jaw and the other on the lower jaw - and serves as their own comparison (split-mouth). This within-person approach removes differences between individuals in oral hygiene, diet, and saliva.\n* The aligner's color over six selected teeth (three upper, three lower) is measured with a dental spectrophotometer (VITA Easyshade V) at placement (day 0) and after 14 days. Each measurement is repeated three times under standardized optical conditions. The amount of color change is expressed as a color-difference value (ΔE).\n* The study hypothesis is that marginal termination design (supragingival versus juxtagingival) is associated with a difference in the 14-day colorimetric change (ΔE00) of the finishing aligner.\n* The study is carried out during the finishing (refinement) stage of orthodontic treatment, when only small residual tooth movements remain, so that color changes can be attributed to wear and edge design rather than to tooth movement.",[27,70],"Esthetics, Dental",[30,72,73,74,75,76,77,35,41],"color stability","spectrophotometry","CIELAB","CIEDE2000","trimming line","marginal termination design","RECRUITING","2026-06-15",{"date":81,"type":46},"2026-06-17",{"date":79,"type":46},{"date":84,"type":22},"2026-08-15",{"name":52,"class":53},{"id":87,"slug":88,"hasResults":11,"nctId":89,"briefTitle":90,"officialTitle":90,"acronym":91,"eligibilityCriteria":92,"healthyVolunteers":17,"sex":18,"minAge":93,"maxAge":4,"enrollmentInfo":94,"targetDuration":4,"studyType":65,"phases":96,"briefSummary":97,"conditions":98,"keywords":100,"overallStatus":78,"whyStopped":4,"lastUpdateSubmitDate":109,"lastUpdatePostDateStruct":110,"startDateStruct":112,"completionDateStruct":114,"leadSponsor":116,"locationsCount":117},"100637585","rem-enhancement-sleep-technology-for-well-being-emotion-and-life-lift-100637585","NCT07589114","REM Enhancement Sleep Technology for Well-being, Emotion, and Life Lift","RESTWELL","Inclusion Criteria:\n\n* age at least 18;\n* the ability to provide consent;\n* the absence of neurocognitive and severe psychiatric disorders.\n\nExclusion Criteria:\n\n* the presence of severe cognitive impairment;\n* the presence of psychosis;\n* inability to understand the informed consent and complete questionnaires.","18 Years",{"count":95,"type":22},360,[67],"This study aims to explore the efficiency of a digital, Smartphone-delivered intervention for improving the quality of REM sleep on the mental health, emotion regulation and overall life quality of users.",[99],"Healthy Adult Participants",[101,102,103,104,105,106,107,108],"digital intervention","sleep","emotion regulation","well-being","quality of life","mental health","technology","REM sleep","2026-05-09",{"date":111,"type":46},"2026-05-15",{"date":113,"type":46},"2025-11-15",{"date":115,"type":22},"2027-02",{"name":52,"class":53},2,{"id":119,"slug":120,"hasResults":11,"nctId":121,"briefTitle":122,"officialTitle":122,"acronym":123,"eligibilityCriteria":124,"healthyVolunteers":17,"sex":18,"minAge":93,"maxAge":4,"enrollmentInfo":125,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":127,"conditions":128,"keywords":130,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":134,"lastUpdatePostDateStruct":135,"startDateStruct":137,"completionDateStruct":139,"leadSponsor":141,"locationsCount":54},"100635372","process-based-psychological-processes-in-alcohol-use-disorder-a-case-control-study-using-pbat-phq-9-and-gad-7-100635372","NCT07551830","Process-Based Psychological Processes in Alcohol Use Disorder: A Case-Control Study Using PBAT, PHQ-9, and GAD-7","PBAT Addiction","Inclusion Criteria:\n\n* age ≥18, the ability to provide informed consent, no psychiatric diagnosis (for the control group).\n\nExclusion Criteria:\n\n* severe cognitive impairment, psychosis, inability to complete questionnaires.",{"count":126,"type":22},200,"This observational study investigates differences in psychological processes and emotional symptoms between individuals with Alcohol Use Disorder (AUD) and a non-clinical control group. PBAT, PHQ-9, and GAD-7 will be used. MANCOVA will test group differences controlling for demographics.",[129],"Alcohol Use Disorder (AUD)",[129,131,132,133],"Process-Based Assessment Tool (PBAT)","depression","anxiety","2026-04-22",{"date":136,"type":46},"2026-04-27",{"date":138,"type":22},"2026-06",{"date":140,"type":22},"2028-06",{"name":52,"class":53},{"id":143,"slug":144,"hasResults":11,"nctId":145,"briefTitle":146,"officialTitle":147,"acronym":4,"eligibilityCriteria":148,"healthyVolunteers":11,"sex":18,"minAge":4,"maxAge":4,"enrollmentInfo":149,"targetDuration":4,"studyType":65,"phases":151,"briefSummary":152,"conditions":153,"keywords":155,"overallStatus":78,"whyStopped":4,"lastUpdateSubmitDate":160,"lastUpdatePostDateStruct":161,"startDateStruct":163,"completionDateStruct":165,"leadSponsor":167,"locationsCount":117},"100582057","robotic-medial-congruent-vs-conventional-medial-pivot-tka-100582057","NCT06858358","Robotic Medial Congruent Vs. Conventional Medial Pivot TKA","Comparison of Robotic-Assisted Medial Congruent and Conventional Medial Pivot Total Knee Arthroplasty: a Prospective, Multicenter Analysis","Inclusion Criteria:\n\nPatients with severe osteoarthritis (greater than III Ahlback)\n\nExclusion Criteria:\n\nPatients who refuse participation in the study Low-grade osteoarthritis",{"count":150,"type":22},300,[67],"This multicenter, prospective cohort study will evaluate whether Robotic-Assisted total knee arthroplasty (RATKA) with a Medial Congruent implant is a successful method to improve implant alignment, insert thickness accuracy, and patient satisfaction, compared to a conventional TKA (cTKA) Medial Pivot technique. It aims to assess and compare clinical and functional outcomes in patients with severe knee osteoarthritis at 3, 6, and 12 months.",[154],"Knee Osteoarthristis",[156,157,158,159],"Robotic","Knee arthroplasty","TKA","ROSA","2025-02-27",{"date":162,"type":46},"2025-03-05",{"date":164,"type":22},"2025-02-24",{"date":166,"type":22},"2026-09",{"name":52,"class":53},""]