[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Georgia Institute of Technology\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":172},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,47,70,96,118,142],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":31,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100565921","multimodal-differences-in-effort-based-decision-making-in-depression-100565921",false,"NCT06648460","Multimodal Differences in Effort-based Decision-Making in Depression","Multimodal Differences in Effort-based Decision-Making in Depression - - Brain Behavior Quantification and Synchronization","BBQS","Inclusion Criteria:\n\n* Matched control group\n\n  * 18-65 years old\n  * Able-bodied\n  * Fluent in English\n  * Able to give written and verbal informed consent to the proposed experiment\n  * Able to comprehend the study procedure, potential risks, and benefits\n* Group with depression\n\n  * Diagnosed with major depression\n  * Quick Inventory of Depression Symptomology (QIDS) score \\> 5\n  * 18-65 years old\n  * Able-bodied\n  * Fluent in English\n  * Able to give written and verbal informed consent to the proposed experiment\n  * Able to comprehend the study procedure, potential risks, and benefits\n\nExclusion Criteria:\n\n* Matched control group\n\n  * Current diagnosed psychiatric disorder (e.g., anxiety, depression, bipolar disorder)\n  * Current pregnancy\n  * BMI \\> 35\n  * Currently on antipsychotics\n* Group with depression\n\n  * Diagnosed with psychotic symptoms\n  * Diagnosed with other neurological or psychiatric disorders\n  * Current pregnancy\n  * BMI \\> 35\n  * Currently on antipsychotics",true,"ALL","18 Years","65 Years",{"count":22,"type":23},90,"ESTIMATED","INTERVENTIONAL",[26],"NA","Major depressive disorder (MDD) is a serious condition that causes long-term symptoms such as feeling sad, losing interest in activities, and having thoughts of self-harm. Difficulty in making an effort is a key factor in functional impairment. Current methods to evaluate this difficulty use clinical assessments and computer-based tasks, but there is a gap between the measurements and real-life behavior. To address this, the study team proposes creating an instrumented behavioral test, HORMES, to objectively assess reduced motivation during everyday activities and measure physiological responses. The study will examine differences in brain activity, autonomic system function, and metabolic energy expenditure in patients with major depression during a decision-making task that involves physical effort.",[29,30],"Depression","Anhedonia",[32,33],"Effort-based decision-making","Physical Effort","NOT_YET_RECRUITING","2026-06-01",{"date":37,"type":38},"2026-06-03","ACTUAL",{"date":40,"type":23},"2026-08-01",{"date":42,"type":23},"2030-09-30",{"name":44,"class":45},"Georgia Institute of Technology","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":17,"sex":18,"minAge":20,"maxAge":54,"enrollmentInfo":55,"targetDuration":4,"studyType":24,"phases":57,"briefSummary":58,"conditions":59,"keywords":4,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":46},"100540984","tvns-during-motor-training-in-older-adults-100540984","NCT06323954","tVNS During Motor Training in Older Adults","Pairing tVNS With Motor Skill Training in Older Adults","Inclusion Criteria:\n\n* 65-84 years old across all races, genders, and ethnicities.\n* Right-handed\n* Physically and cognitively healthy\n\nExclusion Criteria:\n\n* Younger than 65 years old or older than 84 years old\n* Current or history of cardiac disease\n* Have an implanted device such as a neurostimulator or cochlear implant\n* Current or history of tympanic membrane perforation\n* Have a musculoskeletal issue that prevents hand function (e.g., arthritis)\n* Have a vision problem not corrected by glasses or contact lenses\n* Uncorrected auditory impairments\n* Had a stroke or lesion (including tumor) in the brain\n* Had a head injury or brain surgery\n* Suffer from frequent or severe headaches\n* Had a fainting spell or syncope\n* Have any metal in the head such as shrapnel, surgical clips, or fragments from welding or metal work\n* Have any implanted device such as cardiac pacemakers, medical pumps, or intracardiac lines\n* Had any brain-related conditions (i.e. multiple sclerosis, Parkinson, Alzheimer)\n* Had any illness that caused brain injury (i.e. meningitis, aneurysm, brain tumor)\n* Had any head trauma that was associated with a loss of consciousness or diagnosed as a concussion\n* Being treated for any psychiatric condition (i.e. depression, anxiety, PTSD, schizophrenia)\n* Suspected of pregnancy\n* Pregnant\n* Cognitive status issues as confirmed with the Mini-Mental State Exam (MMSE \\\u003C26)\n* Musculoskeletal condition or injury that would limit hand range of motion","84 Years",{"count":56,"type":23},32,[26],"The goal of this study is to learn about the effect of applying transcutaneous vagus nerve stimulation (tVNS) during motor training on motor learning in older adults. The main question it aims to answer is whether applying tVNS after successful motor trials (post-success tVNS) will facilitate the rate of motor learning. Participants will be randomly assigned to tVNS or sham group and receive tVNS or sham, respectively, at the outer ear during finger control training sessions. Finger control performance will be tested before and after the training sessions without outer ear stimulation.",[60],"Older Adults","RECRUITING","2026-04-16",{"date":64,"type":38},"2026-04-21",{"date":66,"type":38},"2025-05-27",{"date":68,"type":23},"2026-07-31",{"name":44,"class":45},{"id":71,"slug":72,"hasResults":11,"nctId":73,"briefTitle":74,"officialTitle":74,"acronym":4,"eligibilityCriteria":75,"healthyVolunteers":17,"sex":18,"minAge":20,"maxAge":76,"enrollmentInfo":77,"targetDuration":4,"studyType":24,"phases":79,"briefSummary":80,"conditions":81,"keywords":85,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":89,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":46},"100354562","neurobiological-mechanisms-of-aging-and-stress-on-prospective-navigation-100354562","NCT03896529","Neurobiological Mechanisms of Aging and Stress on Prospective Navigation","Inclusion Criteria:\n\n* adults 65-80\n* U.S. citizens or permanent residents\n* who speak fluent English\n* willing to come to Georgia Tech to participate in group testing sessions.\n\nExclusion Criteria:\n\n* Individuals will be carefully screened using IRB-approved procedures for safety contraindications to MRI and electrical shock stimulation\n* (e.g., metal or electrical implants, heart arrhythmia, or medication affecting the cardiovascular system \\[e.g. beta-blockers\\]).\n\nThe purpose of this study is to investigate mechanisms of normally functioning memory, and memory-related changes in healthy aging. Thus, any confounding factors that may influence cognition, other than age, will be exclusionary. Potential participants that endorse any of the following conditions will be excluded from the study:\n\n* Epilepsy\n* Dementia\n* Parkinson's disease\n* history of stroke or seizure\n* psychiatric disorders\n* untreated depression or emotional conditions\n* Attention Deficit Disorder\n* Multiple Sclerosis\n* uncontrolled hyper- or hypo-tension\n* untreated Diabetes\n* Sickle Cell Anemia\n* regularly use illegal or psychoactive drugs (e.g., cocaine, alcohol abuse, etc).\n* Additionally, individuals scoring \\\u003C 3 on WAIS-R forward span, \\\u003C 2 on WAIS-R backward span, and failing to name more than 2 vegetable names will be excluded from the study. These exclusions will insure that persons with mild cognitive impairment or typical indications of clinical dementia will be not participate in the research.","80 Years",{"count":78,"type":23},85,[26],"Two hallmarks of both healthy aging and age-related disease are 1) memory and navigational deficits, particularly in orienting towards goal locations and planning how to navigate to them, and 2) increased susceptibility to stress and altered regulation of the stress response. However, there are marked individual differences in these age-related changes. The investigators' proposal will help characterize factors that contribute to this variability.\n\nParticipants will be pseudorandomly assigned to stress-manipulated or control groups. The investigators will give both groups a novel immersive navigation task, validated by the PI in healthy young adults. This paradigm gives participants the opportunity to either (a) flexibly draw on spatial memory in order to plan efficient routes to goal locations, or (b) fall back on inefficient, but cognitively less-demanding, stimulus-response associations (i.e., habits). Using neuroimaging and behavioral measures, the investigators' protocol will test whether experimentally-induced stress leads individuals to bring fewer details about future locations to mind when route planning, and whether such restricted prospective thought ultimately biases participants towards relatively inflexible, habitual actions.",[82,83,84],"Aging","Anxiety","Memory Impairment",[82,86,87,88],"Spatial Memory","Stress","fMRI",{"date":90,"type":38},"2026-04-17",{"date":92,"type":38},"2019-09-24",{"date":94,"type":23},"2026-09-01",{"name":44,"class":45},{"id":97,"slug":98,"hasResults":11,"nctId":99,"briefTitle":100,"officialTitle":101,"acronym":4,"eligibilityCriteria":102,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":103,"enrollmentInfo":104,"targetDuration":4,"studyType":24,"phases":106,"briefSummary":107,"conditions":108,"keywords":4,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":110,"lastUpdatePostDateStruct":111,"startDateStruct":113,"completionDateStruct":115,"leadSponsor":117,"locationsCount":46},"100606751","ankle-exoskeleton-for-stroke-gait-enhancement-100606751","NCT07179627","Ankle Exoskeleton for Stroke Gait Enhancement","Powered Ankle Exoskeleton for Stroke Survivors With Gait Impairment","Inclusion Criteria:\n\n* Between 18-85 years of age\n* Had a stroke at least 6 months prior to study involvement\n* Are community dwelling, which means you do not live in an assisted living facility\n* Are able to provide informed consent to participate in the study activities\n* Can safely participate in the study activities (per self-report)\n* Must have a Functional Ambulation Category (FAC) score of 3 or above, which means you can walk without the assistance of another person\n\nExclusion Criteria:\n\n* Require a walker to walk independently\n* Have a shuffling gait pattern overground\n* Have a Functional Ambulation Category (FAC) score of 2 or lower, which means you require the assistance of another person in order to walk\n* Have a significant secondary deficit beyond stroke (e.g. amputation, legal blindness or other severe impairment or condition) that in the opinion of the Principal Investigator (PI), would likely affect the study outcome or confound the results\n* For exoskeleton-only studies, the exoskeleton device does not fit appropriately or safely, as determined by the research team during the fitting assessment.","85 Years",{"count":105,"type":23},15,[26],"This work will focus on new algorithms for robotic ankle exoskeletons and testing these in human subject tests. Individuals who have previously had a stroke will walk while wearing a robotic exoskeleton on a specialized treadmill as well as during other movement tasks (e.g., overground, stairs, ramps). The study will compare the performance of the advanced algorithm with not using the device to determine the clinical benefit.",[109],"Stroke","2026-02-12",{"date":112,"type":38},"2026-02-17",{"date":114,"type":38},"2026-02-09",{"date":116,"type":23},"2028-12",{"name":44,"class":45},{"id":119,"slug":120,"hasResults":11,"nctId":121,"briefTitle":122,"officialTitle":123,"acronym":4,"eligibilityCriteria":124,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":103,"enrollmentInfo":125,"targetDuration":4,"studyType":24,"phases":127,"briefSummary":128,"conditions":129,"keywords":130,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":134,"lastUpdatePostDateStruct":135,"startDateStruct":137,"completionDateStruct":139,"leadSponsor":141,"locationsCount":46},"100521054","clinical-efficacy-of-exoskeleton-assistance-for-individuals-post-stroke-100521054","NCT06064604","Clinical Efficacy of Exoskeleton Assistance for Individuals Post-Stroke","Clinical Trial: Powered Hip & Ankle Exoskeletons for Stroke Survivors With Gait Impairment","Inclusion Criteria:\n\n* Between 18-85 years of age\n* Stroke at least 6 months prior to study involvement\n* Community dwelling (participant does not live in an assisted living facility)\n* Able to provide informed consent to participate in the study activities\n* Can safely participate in the study activities (per self-report)\n* Must have a Functional Ambulation Category (FAC) score of 3 or above (the participant can walk without the assistance of another person)\n\nExclusion Criteria:\n\n* Requires a walker to walk independently\n* Has a shuffling gait pattern overground\n* Has a Functional Ambulation Category (FAC) score of 2 or lower (the participant requires the assistance of another person in order to walk)\n* Has a significant secondary deficit beyond stroke (e.g. amputation, legal blindness or other severe impairment or condition) that in the opinion of the Principal Investigator (PI), would likely affect the study outcome or confound the results\n* For exoskeleton-only studies, the exoskeleton device does not fit appropriately or safely, as determined by the research team during the fitting assessment.",{"count":126,"type":23},20,[26],"An exoskeleton device is a robotic system designed to improve an individual's ability to move and perform tasks encountered in everyday situations. These devices consist of external rigid limb segments that assists humans through different body movements with the use of actuators. These devices are controlled by an onboard computer that determines the timing and magnitude of assistance deployed to the user. Exoskeleton controller performance is key to providing beneficial assistance that does not inhibit the user's movement. Preceding work will compare the benefit of personalized hip versus ankle joint exoskeleton assistance for improvement of post-stroke gait. It will combine exoskeleton technology with the user's movement feedback to improve wearable robotic assistance to an individual stroke survivor's gait pattern. For the clinical trial research covered under this protocol, the investigator will test various exoskeleton technologies with stroke survivors in real-world contexts, indoors and outdoors, and measure clinically meaningful outcomes and user perceptions regarding technology usability and adoption. The long-term goal is to deploy self-adaptive, adoptable exoskeletons for personalized assistance during community ambulation.",[109],[131,132,133],"Stoke","Robotic Exoskeleton","Gait","2025-11-24",{"date":136,"type":38},"2025-11-26",{"date":138,"type":23},"2027-01-01",{"date":140,"type":23},"2028-12-31",{"name":44,"class":45},{"id":143,"slug":144,"hasResults":11,"nctId":145,"briefTitle":146,"officialTitle":147,"acronym":4,"eligibilityCriteria":148,"healthyVolunteers":11,"sex":18,"minAge":149,"maxAge":150,"enrollmentInfo":151,"targetDuration":4,"studyType":24,"phases":153,"briefSummary":154,"conditions":155,"keywords":158,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":164,"lastUpdatePostDateStruct":165,"startDateStruct":167,"completionDateStruct":169,"leadSponsor":171,"locationsCount":46},"100565815","engaging-kids-with-robotic-exoskeletons-and-gamification-100565815","NCT06647082","Engaging Kids With Robotic Exoskeletons and Gamification","Engaging Kids and Improving Rehab Outcomes by Gamification of Robotic Exoskeletons Combined With Proprioceptive Biofeedback","Inclusion Criteria:\n\n* Age 4-21 years\n* Clinical presence of genu recurvatum or crouch gait during walking\n* Ability to walk nonstop for at least 6 minutes\n* Willing to participate in 5 sessions of therapy with the device with each session lasting no more than 2 hours\n\nExclusion Criteria:\n\n* Inability to take commands from research staff\n* Receipt of Botox injection during study trial will disqualify the participant from participating further\n* Presence of uncontrolled seizures\n* Non-English speaking","4 Years","21 Years",{"count":152,"type":23},5,[26],"Conduct a clinical field trial at CHOA's Day Rehab Program using the clinical exoskeleton in conjunction with visual biofeedback with pediatric patients who present with genu recurvatum or crouch gait over 5 rehabilitation visits.",[156,157],"Genu Recurvatum","Crouch Gait",[159,160,161,162,163],"Pediatric walking impairment","Exoskeleton","Knee exoskeleton","Knee hyperextension","Knee crouch gait","2025-07-16",{"date":166,"type":38},"2025-07-17",{"date":168,"type":23},"2026-06-30",{"date":170,"type":23},"2027-12-30",{"name":44,"class":45},""]