[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Georgia State University\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":462},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,16,0,[8,46,71,97,143,181,213,239,262,292,314,341,361,385,413,441],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100586785","motor-learning-of-fall-resistant-skills-through-slip-and-trip-exposure-in-multiple-sclerosis-100586785",false,"NCT06919900","Motor Learning of Fall Resistant Skills Through Slip and Trip Exposure in Multiple Sclerosis","STRES-MS","Inclusion Criteria:\n\n1. Clinically confirmed multiple sclerosis\n2. At least 45 years old\n3. Able to walk independently at least 25 feet\n4. Able to stand independently for at least 30 seconds\n5. Patient Determined Disability Steps score between 0 and 4\n6. Free from pregnancy\n7. Montreal Cognitive Assessment score of 23 or higher\n\nExclusion Criteria:\n\n1. Previous experience with perturbation training\n2. T-score from the dual x-ray absorptiometry (DXA) scan of less than -2.5\n3. Coexisting psychiatric disorders or other neurological conditions, severe medical illness, or cardiovascular diseases\n4. Participants have had a relapse in the past 8 weeks","ALL","45 Years","89 Years",{"count":20,"type":21},64,"ESTIMATED","INTERVENTIONAL",[24],"NA","The primary purpose of this interventional study is to examine the overall motor learning capacity from exposure to repeated perturbations among ambulatory people with multiple sclerosis (MS). This project will advance our understanding of learning new motor skills from exposure to external perturbations. If it is proven that people with MS can learn motor skills from perturbation training, the findings from this study will pave a theoretical foundation for applying perturbation training as a promising fall prevention intervention for people with MS.",[27],"Multiple Sclerosis (Relapsing Remitting)",[29,30,31,32],"Falls","Fall prevention","Slips","Trips","RECRUITING","2026-06-15",{"date":36,"type":37},"2026-06-17","ACTUAL",{"date":39,"type":37},"2026-04-06",{"date":41,"type":21},"2028-12",{"name":43,"class":44},"Georgia State University","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":54,"sex":16,"minAge":55,"maxAge":18,"enrollmentInfo":56,"targetDuration":4,"studyType":22,"phases":58,"briefSummary":59,"conditions":60,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":45},"100439310","smoke-free-safecare-establishing-a-smoke-free-home-in-cps-involved-families-100439310","NCT05000632","Smoke Free SafeCare: Establishing a Smoke Free Home in CPS-involved Families","Establishing Smoke-free Homes With Families Involved in Child Protective Services: Effectiveness-implementation Trial of an Integrated Program","SFSC","Provider Inclusion Criteria:\n\n* SafeCare providers in this study must 1) have completed the SafeCare workshop and passed field Certification (9 sessions of SafeCare delivered with fidelity according to the SafeCare Fidelity Checklist); 2) be employed at an accredited SafeCare agency in a target state based on Centers for Disease Control and Prevention (CDC) adult smoking data or prior SafeCare research documenting high smoking rates.\n\nCaregiver Inclusion Criteria:\n\n* Caregivers in this study must meet the following inclusion criteria to participate: 1) Referred to a SafeCare Provider study participant; 2) Reports in-home smoking behavior by herself or another person (person must reside in the home 3 or more nights a week) 3) Caregiver must be aged 18 or older and 4) Mother must be a parent to a child between the ages of 0 and 5 (or 0 - 9 if in the state of Oklahoma).\n\nProvider Exclusion Criteria:\n\n* SafeCare providers will be excluded if they have planned for significant employment leave, resignation, or promotion during the study period.\n\nCaregiver Exclusion Criteria:\n\n* We will exclude those who 1) Report that no one smokes in the home; 2) Demonstrate an inability to understand their responsibilities as outlined in the consent form. This will be determined as the research staff verbally go through the consent form with the mothers. If mothers do not understand the consent form and subsequent procedures, they will be excluded.",true,"18 Years",{"count":57,"type":21},268,[24],"Smoke Free SafeCare (SFSC) is a proposed braided intervention consisting of two evidence-based interventions: Some Things are Better Outside (STBO), aimed at promoting smoke free home rules, and SafeCare, aimed at reducing child maltreatment and improving mother and child outcomes. STBO is effective in creating smoke free homes and reducing second-hand smoke in low-SES (socioeconomic status) households. SafeCare is an effective parent training program that is broadly disseminated in child protective services in the United States. SafeCare is a promising mechanism to effectively increase the reach of STBO to reduce SHS (secondhand smoke) exposure in families with documented high rates of tobacco use and children with cumulative risk for negative health outcomes.",[61,62],"Child Maltreatment","Smoking Behaviors","2026-04-21",{"date":65,"type":37},"2026-04-24",{"date":67,"type":37},"2022-04-19",{"date":69,"type":21},"2026-12",{"name":43,"class":44},{"id":72,"slug":73,"hasResults":11,"nctId":74,"briefTitle":75,"officialTitle":76,"acronym":4,"eligibilityCriteria":77,"healthyVolunteers":11,"sex":16,"minAge":55,"maxAge":78,"enrollmentInfo":79,"targetDuration":4,"studyType":22,"phases":81,"briefSummary":82,"conditions":83,"keywords":4,"overallStatus":88,"whyStopped":4,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":45},"100632584","a-mindfulness-based-intervention-for-sexual-assault-survivors-100632584","NCT07515586","A Mindfulness-based Intervention for Sexual Assault Survivors","Leveraging Implementation Science to Develop a Mindfulness-Based Intervention to Reduce Alcohol Misuse and Tobacco Use Among Sexual Violence Survivors","Inclusion Criteria:\n\n* 18-24 years of age\n* currently enrolled as a full-time undergraduate at GSU\n* self-reported lifetime SV victimization\n* self-reported SV victimization in the past 6 months\n* drank alcohol within the last 30 days\n* must own a smartphone\n\nExclusion Criteria:\n\n* not applicable","24 Years",{"count":80,"type":21},120,[24],"The goal is this pilot randomized trial is to learn if intervention 1 is feasible and acceptable. As a secondary goal, we aim to learn if intervention 1 reduces alcohol misuse and tobacco use in sexual assault survivors. The main questions it aims to answer are:\n\n* Is intervention 1 feasible to implement?\n* Is intervention 1 an acceptable intervention among the primary population, sexual assault survivors?\n* Does intervention 1 reduce alcohol misuse and tobacco use?\n\nResearchers will compare intervention 1 to an attention-placebo control group (e.g., online resources on healthy eating and nutrition).\n\nParticipants will:\n\n* take online surveys at baseline, 1 month follow-up, and 3-month follow-up\n* answer text-message questions at baseline and post-test\n* view and engage in an educational program",[84,85,86,87],"Alcohol Misuse","Tobacco Use","Mindfulness","Stress","NOT_YET_RECRUITING","2026-03-31",{"date":91,"type":37},"2026-04-07",{"date":93,"type":21},"2027-10",{"date":95,"type":21},"2030-08",{"name":43,"class":44},{"id":98,"slug":99,"hasResults":11,"nctId":100,"briefTitle":101,"officialTitle":102,"acronym":4,"eligibilityCriteria":103,"healthyVolunteers":11,"sex":16,"minAge":104,"maxAge":105,"enrollmentInfo":106,"targetDuration":4,"studyType":22,"phases":108,"briefSummary":109,"conditions":110,"keywords":119,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":135,"lastUpdatePostDateStruct":136,"startDateStruct":138,"completionDateStruct":140,"leadSponsor":142,"locationsCount":45},"100582737","peanuts-for-cardiometabolic-brain-and-intestinal-health-100582737","NCT06867198","Peanuts for Cardiometabolic, Brain, and Intestinal Health","Impact of Peanuts on Cardiometabolic, Cognitive, and Intestinal Health in Prediabetes Among Racially Diverse Populations","Inclusion Criteria:\n\n* men and women\n* 20-59 years of age\n* BMI: 24.5 - 35.5 kg\u002Fm\\^2\n* Prediabetes (fasting blood glucose levels 100-125 mg\u002FdL and\u002For HbA1c between 5.7-6.4%)\n* Ability to give consent\n\nExclusion Criteria:\n\n* Allergies to peanuts and peanut products\n* Use of insulin, antidiabetic, antibiotics, and anti-inflammatory drugs\n* Active cancer, gastrointestinal, renal, cardiovascular, thyroid, and neurological diseases or severe head injury\n* Smoking\n* Consumes greater than 2 alcoholic beverages per day\n* Consumes antioxidant, probiotic, and prebiotic supplements\n* Pregnant or Lactating\n* Actively participating in a weight loss program\n\nMRI Exclusion Criteria:\n\n* Certain neurological disorders (e.g., uncontrolled seizure disorders)\n* Braces on their teeth, a cardiac pacemaker; hearing aid; other metal in the body or eyes (which may include certain metallic-embedded tattoos), including but not limited to pins, screws, shrapnel, plates, dentures or other metal objects","20 Years","59 Years",{"count":107,"type":21},72,[24],"The overall objective of this 14-month randomized crossover study is to seek evidence demonstrating that daily consumption of peanuts and peanut products improve cardiometabolic, cognitive, and intestinal health in a racially diverse prediabetes population.",[111,112,113,114,115,116,117,118],"Prediabetes","Prediabetes (Insulin Resistance, Impaired Glucose Tolerance)","Cognition","Microvascular Function","Gut Microbiota","Endothelial Function (Reactive Hyperemia)","Arterial Stiffness, Blood Pressure","Adult",[120,121,122,123,124,125,126,127,128,129,130,131,132,133,134],"prediabetes","peanuts","functional foods","nuts","metabolic health","insulin resistance","type II diabetes","microvascular function","dietary intervention","cognitive function","vascular function","neuroimaging","endothelial function","cardiovascular health","gut microbiota","2026-03-23",{"date":137,"type":37},"2026-03-27",{"date":139,"type":37},"2025-03-06",{"date":141,"type":21},"2027-09",{"name":43,"class":44},{"id":144,"slug":145,"hasResults":11,"nctId":146,"briefTitle":147,"officialTitle":148,"acronym":4,"eligibilityCriteria":149,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":150,"enrollmentInfo":151,"targetDuration":4,"studyType":22,"phases":153,"briefSummary":154,"conditions":155,"keywords":168,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":135,"lastUpdatePostDateStruct":175,"startDateStruct":176,"completionDateStruct":178,"leadSponsor":180,"locationsCount":45},"100572617","wild-blueberries-for-gut-brain-and-heart-health-in-adults-with-high-blood-pressure-100572617","NCT06735599","Wild Blueberries for Gut, Brain, and Heart Health in Adults With High Blood Pressure","Effects of Wild Blueberry Consumption on Gut, Brain, and Cardiovascular Health in Non-Hispanic Black and White Adults With High Blood Pressure","Inclusion Criteria:\n\n* Individuals 45-65 years of age\n* Diagnosis of elevated blood pressure or stage 1 hypertension (systolic blood pressure = 120-139 mmHg and\u002For diastolic blood pressure = 80-89 mmHg) for at least 6 months\n* BMI 25-35 kg\u002Fm2 via anthropometric measurements.\n* Ability to give consent\n\nExclusion Criteria:\n\n* Allergies to berries\n* Use of one hypertensive drug for less than three months\n* Use of more than one anti-hypertensive or statin drug, insulin, antibiotics, and anti-inflammatory drugs, active cancer, gastrointestinal, renal, cardiovascular, thyroid, and neurological disorders or severe head injury\n* Smoking\n* Alcohol consumption (\\>2 drinks\u002Fday)\n* Consuming antioxidant, probiotic, and prebiotic supplements\n* Pregnant or lactating\n* Participating in a weight loss program","65 Years",{"count":152,"type":21},40,[24],"The purpose of the study is to determine the effectiveness of wild blueberries on cardiovascular health, cognitive function, and gut microbiota composition in non-Hispanic Black and White adults with elevated blood pressure.",[156,157,158,159,118,113,116,160,161,162,163,164,165,166,167,114],"Hypertension (Without Type 2 Diabetes Mellitus)","High Blood Pressure","Male","Female","Oxidative Stress","Diet","Overweight","Body Composition Measurement","Gut Microbiome","Arterial Stiffness","Caucasian Whites","Inflammation",[169,170,162,157,171,172,173,122,134,174,127],"Blueberries","Hypertension","Endothelial Function","Cognitive Function","Dietary intervention","arterial stiffness",{"date":137,"type":37},{"date":177,"type":37},"2024-09-17",{"date":179,"type":21},"2027-01-01",{"name":43,"class":44},{"id":182,"slug":183,"hasResults":11,"nctId":184,"briefTitle":185,"officialTitle":186,"acronym":4,"eligibilityCriteria":187,"healthyVolunteers":11,"sex":188,"minAge":104,"maxAge":150,"enrollmentInfo":189,"targetDuration":4,"studyType":22,"phases":191,"briefSummary":192,"conditions":193,"keywords":195,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":135,"lastUpdatePostDateStruct":206,"startDateStruct":208,"completionDateStruct":210,"leadSponsor":212,"locationsCount":45},"100572621","wild-blueberries-for-gut-brain-and-cardiometabolic-health-in-prediabetes-100572621","NCT06735651","Wild Blueberries for Gut, Brain, and Cardiometabolic Health in Prediabetes","Wild Blueberries for Gut, Brain, and Cardiometabolic Health in Female Adults With Prediabetes.","Inclusion Criteria:\n\n* Women aged 20-65 years old\n* Prediabetes (fasting blood glucose 100-125 mg\u002FdL and\u002For HbA1c percentage between 5.7-6.4)\n* Body Mass Index between 25-30 kg\u002Fm\\^2\n\nExclusion Criteria:\n\n* Allergies to berries\n* Use of insulin, antidiabetic, antibiotics, and anti-inflammatory drugs\n* Active cancer, gastrointestinal, renal, thyroid, stage 1 \\& 2 hypertension and other cardiovascular diseases, neurological diseases, or severe head injury\n* Smoking\n* Consumes greater than 2 alcoholic beverages per day\n* Consumes antioxidant, probiotic, and prebiotic supplements\n* Pregnant or Lactating\n* Actively participating in a weight loss program\n* Currently taking berry supplements or recently participated in another study taking berry supplements","FEMALE",{"count":190,"type":21},30,[24],"The goal of this clinical trial is to determine the effectiveness of using a freeze-dried wild blueberry powder on cardiometabolic health, cognitive function, and gut microbiota composition in adult women with prediabetes.",[112,159,118,116,165,113,160,115,162,167,114,194],"Body Composition",[169,111,196,197,173,198,199,200,201,202,203,204,114,205],"Insulin Resistance","Functional foods","Endothelial function","Vascular function","Cardiovascular health","Metabolic health","Gut microbiota","Cognitive function","Type II diabetes","Wild Blueberries",{"date":207,"type":37},"2026-03-25",{"date":209,"type":37},"2024-09-20",{"date":211,"type":21},"2026-06-01",{"name":43,"class":44},{"id":214,"slug":215,"hasResults":11,"nctId":216,"briefTitle":217,"officialTitle":218,"acronym":4,"eligibilityCriteria":219,"healthyVolunteers":11,"sex":220,"minAge":221,"maxAge":4,"enrollmentInfo":222,"targetDuration":4,"studyType":224,"phases":4,"briefSummary":225,"conditions":226,"keywords":229,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":232,"lastUpdatePostDateStruct":233,"startDateStruct":235,"completionDateStruct":236,"leadSponsor":238,"locationsCount":45},"100612645","peer-influences-in-alcohol-and-sexual-violence-among-marines-dyads-100612645","NCT07256275","Peer Influences in Alcohol and Sexual Violence Among Marines Dyads","Examining Peer Influences in Alcohol and Sexual Violence Among Marines Using a Dyadic Multimethod Approach","Inclusion Criteria:\n\n* Men\n* Aged 21 or older\n* Currently serving in the United States Marine Corps (USMC)\n* Marine dyads must have engaged in heavy episodic drinking (≥5 drinks in less than two hours) together at least twice in the past month\n* Marine dyads must rate their peer at a minimum of \"somewhat important\" on the Important People Interview.\n\nExclusion Criteria:\n\n* The only exclusion criteria is not meeting inclusion criteria.","MALE","21 Years",{"count":223,"type":21},320,"OBSERVATIONAL","The goal of this experimental study is to examine the complex and multifaceted influence of peers on alcohol-involved sexual violence perpetration (ASVP) in U.S. Marine Corps (USMC) men. The specific aims are:\n\nAim 1: Use ecological momentary assessment (EMA) to examine event-level effects of one's own alcohol use, peer alcohol use, and injunctive norms on ASVP intentions among dyads of Marine men who drink together (n=160 dyads; 320 total participants).\n\nAim 2: Examine the individual and peer effects on ASVP behavior in an experimental paradigm with a gender x confederate (potential victim) intoxication status design. In-the-moment dyad-peer verbalized encouragement for ASVP (\"go cues\") will be assessed by qualitatively coding verbalizations during the interaction.\n\nAim 3: Examine modifiable risk factors on ASVP intentions in vivo (Aim 1; EMA) and ASVP behavior in vitro (Aim 2; experiment) settings.\n\nParticipants will complete: 1) an individual orientation session with informed consent, baseline assessment, and EMA demo; 2) 14 days of EMA completed individually; and 3) a dyadic session to complete an experimental paradigm via videoconferencing. All study procedures will be completed in off-duty time as to not interfere with military duties.",[227,228],"Peer Influence","Alcohol-Involved Sexual Violence Perpetration",[228,230,231,227],"Ecological Momentary Assessment","Sexual Imposition Task","2026-03-18",{"date":234,"type":37},"2026-03-19",{"date":232,"type":37},{"date":237,"type":21},"2030-08-31",{"name":43,"class":44},{"id":240,"slug":241,"hasResults":11,"nctId":242,"briefTitle":243,"officialTitle":244,"acronym":4,"eligibilityCriteria":245,"healthyVolunteers":11,"sex":16,"minAge":246,"maxAge":247,"enrollmentInfo":248,"targetDuration":4,"studyType":22,"phases":250,"briefSummary":251,"conditions":252,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":254,"lastUpdatePostDateStruct":255,"startDateStruct":257,"completionDateStruct":259,"leadSponsor":261,"locationsCount":45},"100410890","effects-of-treadmill-training-and-whole-body-vibration-in-children-with-cerebral-palsy-100410890","NCT04630392","Effects of Treadmill Training and Whole-body Vibration in Children With Cerebral Palsy","Effects of the Addition of a Single Bout of Whole-Body Vibration to a Single Bout of Treadmill Training on Gait and Spasticity in Ambulatory Children With Cerebral Palsy","Inclusion Criteria:\n\n* a medical diagnosis of spastic CP\n* a GMFCS level of I, II, or III\n* age of 6-17 years at the time of data collection\n\nExclusion Criteria:\n\n* history of musculoskeletal injury within the past 3 months\n* history of Botox injections to the lower extremities within the past 3 months\n* history of significant cardiac abnormalities and\u002For uncontrolled seizures\n* any cognitive or behavioral issues that prevent the subject from safely following instructions while walking on the treadmill","6 Years","17 Years",{"count":249,"type":21},20,[24],"Whole-body vibration (WBV) and treadmill training (TT) are commonly-utilized rehabilitation interventions for children with neuromotor disorders. WBV has been shown in the literature to positively affect gait and lower body spasticity in this population. However, the effects of a single session of WBV are generally transient, lasting between ten minutes and two hours. Thus, it may be necessary to combine WBV with another intervention to reinforce improved movement patterns and maximize its potential benefits. Therefore, the aim of this study is to investigate the effects of the addition of a single bout of WBV to a single bout of TT on the lower extremity spasticity and gait parameters of ambulatory children with CP.",[253],"Cerebral Palsy","2026-03-13",{"date":256,"type":37},"2026-03-17",{"date":258,"type":37},"2018-11-12",{"date":260,"type":21},"2026-11-20",{"name":43,"class":44},{"id":263,"slug":264,"hasResults":11,"nctId":265,"briefTitle":266,"officialTitle":267,"acronym":268,"eligibilityCriteria":269,"healthyVolunteers":11,"sex":16,"minAge":55,"maxAge":270,"enrollmentInfo":271,"targetDuration":4,"studyType":22,"phases":273,"briefSummary":275,"conditions":276,"keywords":278,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":283,"lastUpdatePostDateStruct":284,"startDateStruct":286,"completionDateStruct":288,"leadSponsor":290,"locationsCount":291},"100564457","early-phase-1-effects-of-ublituximab-on-motor-functions-in-multiple-sclerosis-100564457","NCT06629428","Effects of Ublituximab on Motor Functions in Multiple Sclerosis","Effects of Ublituximab on Unperturbed and Perturbed Ambulatory Functions in People With Relapsing Multiple Sclerosis","U-PACE","Inclusion Criteria:\n\n1. Ability to provide written, informed consent and to be compliant with the schedule of protocol assessments.\n2. Ages between 18 and 55 years old at screening.\n3. Clinically confirmed active, relapsing forms of MS based on the revised McDonald criteria.\n4. Can walk at least 25 feet independently with or without assistive devices at screening.\n5. Can stand independently for at least 30 seconds.\n6. Not pregnant at screening and throughout the study.\n\n   * A negative urine or serum pregnancy test must be available for premenopausal women and for women \\< 12 months after the onset of menopause at screening, unless they have undergone surgical sterilization.\n   * Women of childbearing potential must agree to remain abstinent (refrain from heterosexual intercourse) or use one method of contraception with a failure rate of \\< 1% per year or a barrier method supplemented with spermicide. Contraception must continue for the duration of study treatment and for at least 6 months after the last dose of study treatment.\n\n     * A woman is considered to be of childbearing potential if she is postmenarcheal, has not reached a postmenopausal state (≥ 12 continuous months of amenorrhea with no identified cause other than menopause), and has not undergone surgical sterilization (removal of the ovaries and\u002For uterus).\n     * Examples of contraceptive methods with a failure rate of \\< 1% per year include bilateral tube ligation, male sterilization, established hormonal contraceptives that inhibit ovulation, hormone-releasing intrauterine devices, and copper intrauterine devices.\n     * The reliability of sexual abstinence should be evaluated in relation to the duration of the clinical trial and the preferred and usual lifestyle of the patient. Periodic abstinence and withdrawal are not acceptable methods of contraception.\n     * Examples of barrier methods supplemented with the use of spermicide include male or female condom, vaginal ring, cap, diaphragm, or sponge.\n7. No other neurological conditions and recent musculoskeletal injuries.\n8. Can read and understand English.\n9. No significant cognitive impairment.\n\nExclusion Criteria:\n\nBasic Exclusion Criteria\n\n1. History of MS types other than relapsing MS at screening (such as primary-progressive MS, inactive SPMS).\n2. History of life-threatening infusion reaction on ublituximab, any of its ingredients, or prior anti-clusters of differentiation 20 (CD20) therapy.\n3. Hypersensitive to any of the ingredients of ublituximab.\n4. Do not understand English.\n\n   Exclusions Related to General Health\n5. Pregnancy or lactation.\n6. Have any other known neurological diseases which may mimic MS, including but not limited to: Neuromyelitis optica, Lyme disease, untreated vitamin B12 deficiency, neurosarcoidosis, and cerebrovascular disorders.\n7. History of clinically significant central nervous system (CNS) trauma (e.g., traumatic brain injury, cerebral contusion, spinal cord compression, etc.).\n8. History of liver disease.\n9. Active hepatitis B virus (HBV) confirmed by positive results for Hepatitis B surface antigen (HBsAg) and anti-HBV tests.\n10. Current evidence or known history of clinically significant infection.\n11. Suffering from coexisting psychiatric disorders, neurological disorders, or severe medical illness.\n12. Current severe depression and\u002For suicidal ideation.\n13. Significant cognitive impairment (Montreal Cognitive Assessment or Montreal Cognitive Assessment (MoCA) score \\< 24).\n14. New onset, unstable orthopedic comorbid diagnoses (within 3 months and uncontrolled).\n15. History or currently active primary or secondary immunodeficiency.\n16. Receipt of a live vaccine within 6 weeks before baseline.\n17. Skin is allergic to transparent double-side tapes.\n18. Any concomitant disease that may require chronic treatment with systemic corticosteroids or immunosuppressants during the course of the study.\n19. History or currently active primary or secondary immunodeficiency.\n20. Lack of peripheral venous access.\n21. History of severe allergic or anaphylactic reactions to humanized or murine monoclonal antibodies.\n22. Significant or uncontrolled somatic disease or any other significant disease that may preclude a patient from participating in the study.\n23. Congestive heart failure (NYHA III or IV functional severity).\n24. Known active bacterial, viral, fungal, mycobacterial infection or other infection, excluding fungal infection of nail beds.\n25. Infection requiring hospitalization or treatment with i.v. antibiotics within four weeks prior to baseline visit or oral antibiotics within two weeks prior to baseline visit.\n26. History or known presence of recurrent or chronic infection (e.g., hepatitis B or C, HIV, syphilis, tuberculosis).\n27. History of progressive multifocal leukoencephalopathy (PML).\n28. History of malignancy, including solid tumors and hematological malignancies, except basal cell carcinoma, in situ squamous cell carcinoma of the skin, and in situ carcinoma of the cervix of the uterus that has been previously completely excised with documented clear margins.\n29. History of alcohol or drug abuse within 24 weeks prior to baseline.\n30. History or laboratory evidence of coagulation disorders.\n\n    Exclusions Related to Medications\n31. Receipt of any live of live-attenuated vaccines within 4 weeks prior to first drug product administration.\n32. Treatment with any investigational agent within 24 weeks of screening (Visit 1) or five half-lives of the investigational drug (whichever is longer).\n33. Systemic corticosteroid therapy within 4 weeks prior to screening.\n34. Any previous treatment with alemtuzumab (Campath), anti-cluster of differentiation 4 (CD4), cladribine, mitoxantrone, daclizumab, tecfidera (BG12), teriflunomide, laquinimod, total body irradiation or bone marrow transplantation.\n35. Treatment with cyclophosphamide, azathioprine, mycophenolate mofetil (MMF), cyclosporine, methotrexate, or natalizumab within 24 months prior to screening.\n36. Treatment with intravenous immunoglobulin within 12 weeks prior to baseline.\n37. Treatment with anti-CD20 or other B cell-directed treatment.\n\n    Exclusions Related to Motor Function\n38. Cannot walk at least 25 feet and stand for at least 30 seconds independently.\n39. Weak or blind vision may impair their ability to walk.\n\n    Exclusions Related to Musculoskeletal, Cardiovascular, and Orthopedic Conditions\n40. Broken bones as an adult in the past year.\n41. Have received neurological treatment, such as Botox, in the past six months.\n42. Heart attack, angioplasty, or coronary artery bypass graft in the past six months.\n43. Congestive heart failure (NYHA III or IV functional severity).\n44. Surgery on back, hip, shoulder, or total joint replacement of hip or knee joint less than two years ago.\n45. Respiratory conditions (lung cancer, bronchitis, emphysema, asthma, shortness of breath) not under regular medical care or the patient is medically unstable.","55 Years",{"count":272,"type":21},25,[274],"EARLY_PHASE1","The purpose of this study is to test if ublituximab changes walking functions and fall risk in people with relapsing multiple sclerosis (RMS). Twenty-five qualified people with RMS will undergo a 48-week ublituximab treatment. Before, 24 weeks into, and after the treatment, their ambulatory function, disability status, and cognition will be assessed. Additionally, they will experience large-scale slip perturbations on a treadmill under the protection of a safety harness at the last assessment. The outcome measures will be compared across the assessments to examine the effects of ublituximab on improving their walking function, disability status, cognition, and the responses to the unexpected slip perturbation.",[277],"Multiple Sclerosis (MS) - Relapsing-remitting",[279,280,281,282,113],"ublituximab","gait function","disease progression","perturbed walking","2026-02-05",{"date":285,"type":37},"2026-02-09",{"date":287,"type":37},"2025-11-13",{"date":289,"type":21},"2026-12-31",{"name":43,"class":44},2,{"id":293,"slug":294,"hasResults":11,"nctId":295,"briefTitle":296,"officialTitle":297,"acronym":298,"eligibilityCriteria":299,"healthyVolunteers":11,"sex":16,"minAge":150,"maxAge":300,"enrollmentInfo":301,"targetDuration":4,"studyType":22,"phases":302,"briefSummary":303,"conditions":304,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":306,"lastUpdatePostDateStruct":307,"startDateStruct":309,"completionDateStruct":311,"leadSponsor":313,"locationsCount":45},"100455087","perturbation-training-reduces-falls-in-people-with-alzheimers-disease-ad-100455087","NCT05205980","Perturbation Training Reduces Falls in People With Alzheimer's Disease (AD)","Motor Learning of Fall Resistant Skills From Laboratory-induced Falling Among People With Mild Alzheimer's Disease","STAD","Inclusion Criteria:\n\n* Participants must be at least 65 years old;\n* Participants have a clinical diagnosis of probable AD;\n* Participants can read and understand English;\n* Participants must be able to walk independently at least 25 feet;\n* Participants must be able to stand independently for at least 30 seconds;\n* Participants must have a Montreal Cognitive Assessment score of 11-21 or Mini Mental Status Examination score between 18 and 23.\n\nExclusion Criteria:\n\n* Individuals have ever experienced perturbation training;\n* Individuals have hypotension or uncontrolled hypertension;\n* Individuals exhibit osteoporosis;\n* Participants suffer from coexisting psychiatric disorders, or other neurological conditions, or injuries, etc.","90 Years",{"count":190,"type":21},[24],"This study will examine the overall capacity of people with Alzheimer's disease learning fall-resistant skills from perturbation training.",[305],"Alzheimer Disease","2026-02-02",{"date":308,"type":37},"2026-02-04",{"date":310,"type":37},"2023-04-28",{"date":312,"type":21},"2026-10-30",{"name":43,"class":44},{"id":315,"slug":316,"hasResults":11,"nctId":317,"briefTitle":318,"officialTitle":319,"acronym":4,"eligibilityCriteria":320,"healthyVolunteers":54,"sex":16,"minAge":221,"maxAge":4,"enrollmentInfo":321,"targetDuration":4,"studyType":22,"phases":323,"briefSummary":324,"conditions":325,"keywords":329,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":333,"lastUpdatePostDateStruct":334,"startDateStruct":336,"completionDateStruct":338,"leadSponsor":340,"locationsCount":291},"100576641","communicating-about-nicotine-reduction-in-cigarettes-100576641","NCT06787937","Communicating About Nicotine Reduction in Cigarettes","Communicating About Nicotine and Differential Risks of Tobacco Products in Priority Populations","Inclusion Criteria:\n\n* Age 21+ years\n* Current smoker (self-report as having smoked 100 cigarettes in their lifetime and currently smoking on 27+ days out of past 30, expired breath carbon monoxide \\[CO\\] ≥6ppm to assess regular smoking)\n* Can speak, read, and write in English\n* Available for period of study\n* Willing to try novel research cigarettes\n\nExclusion Criteria:\n\n* Pregnancy or lactation\n* Member of the same household as a study subject\n* Unwilling to use research cigarettes as part of the trial",{"count":322,"type":21},1230,[24],"The goal of this clinical trial is to learn how a messaging campaign about reduced nicotine cigarettes and policy, combined with the use of very low nicotine cigarettes (VLNCs), affects smoking behavior and attitudes among adult smokers. The study also aims to assess the efficacy of the messages in different populations, including smokers with past-month serious psychological distress (SPD), low socioeconomic status (SES), and those in neither category.\n\nThe primary hypothesis is: exposure to messages in combination with VLNC use will lead to less cigarettes use compared to VLNCs without messages.\n\nResearchers will compare: The effects of receiving VLNCs with messages (treatment group) to receiving VLNCs without messages (control group).\n\nParticipants will: Complete a baseline survey and be randomly assigned to one of two groups: treatment (VLNCs + messages) or control (VLNCs only). Attend weekly study visits for surveys, breath samples, and receive supply of VLNCs , either with or without the messaging campaign. Complete brief daily surveys through text messages.",[326,327,328],"Tobacco Products","Smoking Behavior","Cigarette Use",[330,331,332],"smoking","health communication","very low nicotine cigarettes","2025-10-28",{"date":335,"type":37},"2025-10-29",{"date":337,"type":37},"2025-09-11",{"date":339,"type":21},"2029-01-31",{"name":43,"class":44},{"id":342,"slug":343,"hasResults":11,"nctId":344,"briefTitle":345,"officialTitle":345,"acronym":4,"eligibilityCriteria":346,"healthyVolunteers":11,"sex":16,"minAge":55,"maxAge":347,"enrollmentInfo":348,"targetDuration":4,"studyType":22,"phases":349,"briefSummary":350,"conditions":351,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":353,"lastUpdatePostDateStruct":354,"startDateStruct":356,"completionDateStruct":358,"leadSponsor":360,"locationsCount":45},"100592530","clinical-and-biochemical-effects-of-a-defined-plant-based-diet-on-heart-disease-100592530","NCT06994624","Clinical and Biochemical Effects of a Defined Plant-Based Diet on Heart Disease","Inclusion Criteria:\n\n* Diagnosis with coronary artery disease (based on current EKG or prior diagnosis)\n* New patient\n\nExclusion Criteria:\n\n* Current tobacco use\n\n  -\\>2 glasses of wine for woman, \\>1 glass for men\n* Current cancer diagnosis\n* An ongoing clinically defined infection\n* eGFR \\\u003C 30\n* Pregnancy\n* Lactation\n* Prior hospitalization within past 6 months\n* Unstable angina\n* Heart catheterization within past 6 months\n* Cardiac perfusion study past 6 months\n* Have not been on any form of a plant-based diet previously","75 Years",{"count":190,"type":21},[24],"A plant-based diet will be utilized in the treatment of coronary artery disease.",[352],"Coronary Artery Disease","2025-05-20",{"date":355,"type":37},"2025-05-29",{"date":357,"type":37},"2025-04-25",{"date":359,"type":21},"2027-05-01",{"name":43,"class":44},{"id":362,"slug":363,"hasResults":11,"nctId":364,"briefTitle":365,"officialTitle":366,"acronym":4,"eligibilityCriteria":367,"healthyVolunteers":54,"sex":16,"minAge":55,"maxAge":368,"enrollmentInfo":369,"targetDuration":4,"studyType":22,"phases":371,"briefSummary":372,"conditions":373,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":377,"lastUpdatePostDateStruct":378,"startDateStruct":380,"completionDateStruct":382,"leadSponsor":384,"locationsCount":45},"100450467","just-in-time-intervention-to-reduce-alcohol-facilitated-intimate-partner-violence-perpetration-100450467","NCT05145868","Just-In-Time Intervention to Reduce Alcohol-Facilitated Intimate Partner Violence Perpetration","Evaluation and Optimization of a Just-in-Time Messaging Intervention to Reduce Alcohol-Facilitated Intimate Partner Violence Perpetration Among At-Risk Young Adult Men and Women","Inclusion Criteria:\n\n* 18-30 years old\n* Consumed alcohol an average of 2 times per week in last 3 months\n* At least two instances of heavy episodic drinking in last month\n* Currently in a romantic relationship\n* History of IPV perpetration within last 3 months\n* Willing to provide cell phone number and carrier and receive text messages for 30 days\n\nExclusion Criteria:\n\n* None","30 Years",{"count":370,"type":21},400,[24],"Acute alcohol intoxication is a robust predictor of intimate partner violence (IPV) perpetration for young adult men and women; therefore, interventions delivered proximally to drinking episodes - a period of high risk - are needed to reduce alcohol-facilitated IPV. This project seeks to improve public health by delivering a just-in-time text messaging intervention proximally to drinking episodes and evaluating the impact of the intervention on alcohol-facilitated IPV in a sample of at-risk young adult men and women. Additionally, through an innovative design this project is poised to answer these important questions: whether receiving a message, when, for whom, what type, and under what conditions this just-in-time messaging intervention leads to reductions in alcohol use and IPV perpetration.",[374,375,376],"Alcohol Drinking","Aggression","Emotion Regulation","2025-03-12",{"date":379,"type":37},"2025-03-14",{"date":381,"type":37},"2023-01-03",{"date":383,"type":21},"2026-04-30",{"name":43,"class":44},{"id":386,"slug":387,"hasResults":11,"nctId":388,"briefTitle":389,"officialTitle":389,"acronym":390,"eligibilityCriteria":391,"healthyVolunteers":11,"sex":16,"minAge":392,"maxAge":221,"enrollmentInfo":393,"targetDuration":4,"studyType":22,"phases":395,"briefSummary":396,"conditions":397,"keywords":399,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":405,"lastUpdatePostDateStruct":406,"startDateStruct":408,"completionDateStruct":410,"leadSponsor":412,"locationsCount":45},"100583828","effect-of-a-humanoid-robot-with-virtual-reality-games-to-train-arm-function-in-children-with-cerebral-palsy---thrive-trial-100583828","NCT06881407","Effect of a Humanoid Robot With Virtual Reality Games to Train Arm Function in Children With Cerebral Palsy - THRIVE Trial","THRIVE","Inclusion Criteria:\n\n1. Participants are between the ages of 5 and 21 years;\n2. diagnosed with spastic CP;\n3. have a manual ability classification system (MACs) level I-III;\n4. able to sit with trunk supported;\n5. are able to reach forward for more than half of their arm length;\n6. are able to comprehend and complete a three-steps commands;\n7. are able to see a TV screen (with or without corrected vision); and\n8. their primary caregiver is willing to follow the desired intervention dosing and all evaluation measurements.\n\nExclusion Criteria:\n\n1. they have received surgery or botulinum toxin type A injection in the training arm within the preceding 4 months or are scheduled to receive it during the planned intervention period, or\n2. if they have a severe attention deficit or uncontrolled epilepsy, which may possibly be triggered by the light or sound of the video games.","5 Years",{"count":394,"type":21},42,[24],"About 60% of children with cerebral palsy (CP) have impaired arm function. Improving arm function requires hundreds of repetitions per day, which is impossible in a single clinical visit. Thus, therapeutic exercises should be sustained in the home environment; however, the compliance in performing home exercise is low due to poor motivation, boredom, and forgetfulness. A better home program is needed. The objective of this project is to examine the effect of our developed \"THRIVE\" system (Therapeutic Humanoid Robot In Virtual Environment: the combination of robot with virtual reality games), which can provide a motivating and tailored upper-extremity intervention program with instant feedback, to improve arm function in children with CP at their home. The investigators believe the newly developed \"THRIVE\" system can increase children's engagement and motivation in home exercises as the robot is their playmate to demonstrate and correct their movements. The investigators will also interview parents and children with CP to understand their impression of using technology at home to shape the intervention. The expected outcome is that children with CP receiving \"THRIVE\" will improve their arm function more and have better engagement than those who receive VR alone immediately after intervention and at follow-up. The long-term goal is to have the \"THRIVE\" system be the optimal home exercise platform as it can provide challenging but motivating exercises to improve children's arm function while assisting parents in supervising their children with CP to complete home exercises.",[398],"Cerebral Palsy (CP)",[400,401,402,403,404],"Cerebral palsy","Virtual Reality","Humanoid Robot","Home-based Intervention","Arm Function","2025-03-11",{"date":407,"type":37},"2025-03-18",{"date":409,"type":37},"2025-02-25",{"date":411,"type":21},"2027-08-31",{"name":43,"class":44},{"id":414,"slug":415,"hasResults":11,"nctId":416,"briefTitle":417,"officialTitle":418,"acronym":419,"eligibilityCriteria":420,"healthyVolunteers":54,"sex":16,"minAge":55,"maxAge":368,"enrollmentInfo":421,"targetDuration":4,"studyType":22,"phases":423,"briefSummary":424,"conditions":425,"keywords":429,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":433,"lastUpdatePostDateStruct":434,"startDateStruct":436,"completionDateStruct":438,"leadSponsor":440,"locationsCount":45},"100562862","timing-and-facilitation-effects-of-theta-burst-stimulation-in-the-reading-and-language-networks-100562862","NCT06608680","Timing and Facilitation Effects of Theta-Burst Stimulation in the Reading and Language Networks","Timing and Facilitation Effects of Theta-Burst Stimulation in the Reading and Language Systems","TAFE","Inclusion Criteria:\n\n* Subjects must have a minimum of low average intellectual functioning (\\>=80) on at least one subscale on the Wechsler Abbreviated Scale of Intelligence-2 (WASI-2; Wechsler, 2011) to be included.\n* Within a normal range of reading skills as \\>85 on the Test of Word Reading Efficiency - Second Edition (TOWRE-2; Torgesen et al., 2012) and the Woodcock-Johnson IV Tests of Achievement (WJ-IV; Schrank et al., 2014)\n* Individuals with a documented history of learning disability will not be included. This will be determined via demographics questionnaire.\n* Subjects must be between the ages of 18 and 30 to be included. This will be determined via demographics questionnaire.\n* Because reading is critically linked to language, only individuals who are native speakers of English will be included in the study. This will be determined via demographics questionnaire.\n* The reading network is typically localized to the left side of the brain. However, left-handed individuals may have different brain lateralization, introducing an important confound to the study. Therefore, only right-handed individuals will be included in the study. This will be determined via demographics questionnaire.\n* Individuals who have hearing deficits (\\>25dB at 500+ Hz), visual deficits (\\>20\u002F40), serious emotional problems, certain neurological conditions (e.g., uncontrolled seizure disorders) will not be included. This will be determined via CABI Screening Forms and Demographics Questionnaire.\n* Individuals with certain metals in their bodies or with certain health conditions will not be included. If an individual has braces on their teeth, a cardiac pacemaker; hearing aid; other metal in their body or eyes (which may include certain metallic-embedded tattoos), including but not limited to pins, screws, shrapnel, plates, dentures or other metal objects they will not be included. This will be determined via CABI Screening forms.\n* Individuals with MRI Screening and Contraindication Forms which do not pass MRI Tech review will not be included.\n* Individuals with TMS Screening Forms which do not pass TMS Tech review will not be included.",{"count":422,"type":21},50,[24],"The purpose of this study is to understand how transcranial magnetic stimulation affects how quickly, easily, and accurately a person read. Transcranial magnetic stimulation is a technique that uses magnetic fields to briefly affect how well certain brain regions function. The investigators would like to better understand how long the effects of transcranial magnetic stimulation occur in the reading system and at what point the effect is strongest in this system. The main questions it aims to answer are:\n\n1. At what point after stimulation are the greatest effects on behavior seen\n2. How excitatory and inhibitory stimulation affect behavior\n\nResearchers will compare stimulation types against a sham condition to see effects on reading and language behavior.\n\nParticipants will be asked to\n\n* undergo reading, language, and cognitive testing\n* receive an MRI\n* receive TMS stimulation\n* perform language, reading, and motor tasks",[426,427,428],"Reading","Language","Control Subjects",[430,431,432,426,427],"transcranial magnetic stimulation","TMS","MRI","2024-09-19",{"date":435,"type":37},"2024-09-23",{"date":437,"type":37},"2023-05-01",{"date":439,"type":21},"2028-12-31",{"name":43,"class":44},{"id":442,"slug":443,"hasResults":11,"nctId":444,"briefTitle":445,"officialTitle":446,"acronym":4,"eligibilityCriteria":447,"healthyVolunteers":54,"sex":16,"minAge":221,"maxAge":368,"enrollmentInfo":448,"targetDuration":4,"studyType":22,"phases":450,"briefSummary":451,"conditions":452,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":454,"lastUpdatePostDateStruct":455,"startDateStruct":457,"completionDateStruct":459,"leadSponsor":461,"locationsCount":45},"100493185","biphasic-effects-of-acute-alcohol-intoxication-on-bystander-intervention-100493185","NCT05701865","Biphasic Effects of Acute Alcohol Intoxication on Bystander Intervention","Biphasic Effects of Acute Alcohol Intoxication on Bystander Intervention for Sexual Violence","Inclusion Criteria:\n\n* Between the ages of 21 and 30\n* Report that on at least 3 days in the past year they have consumed an alcohol quantity on a single occasion that was equal or greater to the dose administered in the lab\n\nExclusion Criteria:\n\n* Currently seeking treatment or in recovery for an alcohol or substance use disorder\n* A medical condition or medication use in which alcohol consumption is medically contraindicated\n* Pregnant, nursing, or has engaged in sexual intercourse without effective contraception in the past two weeks\n* If the participant is less than six feet tall and weighs over 250 pounds or is over six feet tall and weighs over 300 pounds",{"count":449,"type":21},192,[24],"The goal of this experimental study is to examine the effect of alcohol, gender, and bystander attitudes on bystander barriers and sexual violence intervention among young adult men and women (age 21-20). The main questions it aims to answer are:\n\n* Does alcohol intoxication and gender influence bystander barriers and sexual violence intervention?\n* Does alcohol intoxication have a greater impact on bystander barriers and sexual violence intervention among men, compared to women?\n* Does alcohol intoxication have a greater impact on bystander barriers and sexual violence intervention among those with higher, compared to lower, prosocial bystander attitudes?\n\nParticipants will be randomly assigned to one of two beverage conditions (alcohol or control beverage) and those assigned to alcohol will complete the study on either the ascending or descending alcohol limb. Participants will project themselves into a heat-of-the moment, risky sexual violence scenario that will assess bystander barriers and behavioral intentions. Researchers will compare those assigned to the alcohol and control beverage condition and men\u002Fwomen to see if this impacts bystander barriers and sexual violence intervention.",[453],"Alcohol Intoxication","2024-06-10",{"date":456,"type":37},"2024-06-12",{"date":458,"type":37},"2023-03-09",{"date":460,"type":21},"2024-12-31",{"name":43,"class":44},""]