[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"German Institute of Human Nutrition\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":221},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,7,0,[8,51,73,107,134,164,191],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":33,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":50},"100585905","cold-water-and-decision-making-100585905",false,"NCT06908447","Cold Water and Decision-Making","Voluntary Cold-Water Immersion Effects on Value-Based Choice","CoVa","Inclusion Criteria:\n\n* 18-40 years of age\n* Consent to participate\n* Fluency in German\n* Physically and mentally healthy\n* BMI 18-30 kg\u002Fm2\n* Normal day-night rhythm\n\nExclusion Criteria:\n\n* Raynaud syndrome\n* Cold urticaria\n* High resting heart rate (\\>160 beats per minute)\n* Acute infection\n* Diagnosed current or former illnesses of\n\n  * Brain and mind\n  * Heart and blood circulation\n  * Gastrointestinal system\n  * Endocrine system\n  * Other serious past or present medical conditions\n* Wearing of medical devices (e.g., pacemaker)\n* Fear of blood, needles, or phlebotomy\n* Allergies to plasters, gels, and other medical equipment\n* Allergies to commercially available liquid meals (e.g., shakes, yfood Labs GmbH)\n* Recurrent intake of medication which affect metabolism\n* Regular nicotine consumption (e.g., vaping, cigarettes)\n* Excessive alcohol consumption (\\>14 servings\u002Fweek)\n* Recent illegal drug consumption (within 2 weeks prior)\n* Strong mental or physical stress\n* Excessive exercise (\\>2 h high-intensity exercise\u002Fday)\n* Pregnancy or breastfeeding\n* Inability to wear skin-exposing swimwear, e.g., for religious reasons\n* Affinity for winter swimming, cryotherapy, breathwork (\\>3 times\u002Fyear)",true,"ALL","18 Years","40 Years",{"count":22,"type":23},40,"ESTIMATED","INTERVENTIONAL",[26],"NA","The behavioral within-subject cross-over design study \"CoVa\" aims to investigate the effect of a short-term full-body cold-water immersion vs. warm-water immersion control on value-based choice, psychological well-being, and peripheral physiology.",[29,30,31,32],"Behavior","Stress","Quality of Life","Psychological Wellbeing",[34,35,30,36,37],"Decision-Making","Psychology","Cold-Exposure","Cold-Water Immersion","RECRUITING","2026-04-17",{"date":41,"type":42},"2026-04-21","ACTUAL",{"date":44,"type":42},"2025-08-28",{"date":46,"type":23},"2026-12-31",{"name":48,"class":49},"German Institute of Human Nutrition","OTHER",1,{"id":52,"slug":53,"hasResults":11,"nctId":54,"briefTitle":55,"officialTitle":55,"acronym":56,"eligibilityCriteria":57,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":58,"targetDuration":4,"studyType":24,"phases":60,"briefSummary":61,"conditions":62,"keywords":4,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":70,"leadSponsor":72,"locationsCount":4},"100631819","breathing-and-decision-making-prolex-context-100631819","NCT07505641","Breathing and Decision-Making (ProlEx-Context)","ProlEx-Context","Inclusion Criteria:\n\n* 18- to 40-year-old men and women\n* Consent to participate\n* Fluent in German\n* Right-handed\n* Physically and mentally healthy without regular medication\n* Body-mass index of 18-25 kg\u002Fm2\n* Alcohol consumption of less than 15 glasses a week (equivalent to one glass of wine\u002Fbeer, a glass of higher-percentage alcohol counts as two glasses of beer)\n* No illegal drug consumption in the week previous to the experiment\n* No smoking\n* No competitive athletes\n* Normal day-night rhythm (no shift work)\n* Normal vision without required vision correction (i.e., glasses, contact lenses; ability to clearly read texts at a distance of up to 50 cm without vision aids)\n\nExclusion Criteria:\n\n* Former or current illnesses of:\n* Brain or mind (including anxiety disorders, depression, eating disorders, personality disorders, alcohol, drugs or drug dependence, neurological disorders other than occasional headache, psychiatric or neurological abnormalities)\n* Heart or blood circulation\n* Lung Diseases\n* Other serious past or present medical conditions (for example, metabolic syndrome, diabetes)\n* Current medication and medication over a period of two weeks prior to the examination\n* Other serious health problems or present strong mental or physical stress\n* Current infection or excessive stress\n* Missing consent to receive information about incidental findings from the MRI\n* Tendency to claustrophobia, dizziness, or panic attacks\n* Wearing a non-removable pacemaker, defibrillator, hearing aid, drug pump, neurostimulator or implant with solenoid valve (e.g., artificial bowel outlet)\n* Metal parts or implants inside the body, for example, due to surgery or injury with a metallic foreign object (e.g., hip replacements, artificial joints, heart valves, vessel occlusions or dilatations, surgical clips, bone screws or plates, coil, shunts, catheters, electrodes, coils, radiation sources, shrapnel, projectiles, stents)\n* Having non-removable metal parts or metal-containing devices on or in the body\n* Having ferromagnetic metal parts or implants inside the body (e.g., hip replacements, artificial joints, heart valves, vessel occlusions or dilatations, surgical clips, bone screws or plates, coils, shunts, catheters, electrodes, coils, radiation sources, shrapnel, projectiles, stents)\n* Wearing magnetically fixed implants (e.g. amalgam fillings, glass eye)\n* Professionally or privately being involved in the processing of ferromagnetic metals\n* Large tattoos (whole limbs)\n* Pregnancy\n* Wearing an intra-uterine device\n* Having tinnitus\n* Extensive lung function (e.g. apnoe diver, singer, professional musician with lung-involving instruments)\n* Previous participation in the ProlEx-MRI study (the precursor to the current study)",{"count":59,"type":23},50,[26],"The ProlEx-Context study aims to investigate how a slow-paced breathing technique with prolonged exhalation affects decision-making in the context of acute social stress.",[63,64,34],"Breathing Techniques","Stress Management","NOT_YET_RECRUITING","2026-03-26",{"date":68,"type":42},"2026-04-01",{"date":68,"type":23},{"date":71,"type":23},"2027-04-01",{"name":48,"class":49},{"id":74,"slug":75,"hasResults":11,"nctId":76,"briefTitle":77,"officialTitle":78,"acronym":79,"eligibilityCriteria":80,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":81,"enrollmentInfo":82,"targetDuration":4,"studyType":24,"phases":84,"briefSummary":85,"conditions":86,"keywords":90,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":50},"100606110","precise-eating-time-to-improve-glycemic-control-and-cardiometabolic-health-in-prediabetes-and-diabetes-100606110","NCT07171281","Precise Eating Time to Improve Glycemic Control and Cardiometabolic Health in Prediabetes and Diabetes","Precise Eating Time to Improve Glycemic Control and Cardiometabolic Health in Prediabetes and Diabetes: the GLYCOTIME Trial","GLYCOTIME","Inclusion Criteria:\n\n* Overweight or obesity (BMI 25-40 kg\u002Fm²)\n* Healthy glucose metabolism (fasting glucose \\\u003C100 mg\u002Fdl and glucose after 2 hours OGTT \\\u003C140 mg\u002Fdl)\n* OR impaired glucose metabolism (fasting glucose 100-125 mg\u002Fdl and\u002For glucose after 2 hours OGTT 140-199 mg\u002Fdl and\u002For HbA1c 5.7-6.4%)\n* OR type 2 diabetes (according to existing medical diagnosis or fasting glucose \\>126 mg\u002Fdl and\u002For glucose after 2 hours OGTT \\>200 mg\u002Fdl and\u002For HbA1c ≥6.5%)\n* Daily eating window ≥12 hours\n\nExclusion Criteria:\n\n* Weight changes \\> 5% within past 3 months\n* Shift work\n* Traveling across more than one time zone within one month prior to the study\n* Pregnancy and breastfeeding\n* Eating disorders, food intolerance\u002Fallergy to ingredients in the diet product, vegan diet, practicing time-restricted eating\n* Severe chronic illnesses or other conditions that are incompatible with the planned intervention and examination program (e.g. type 1 diabetes, recent cardiovascular event, malabsorption, cancer in the last two years, etc.)\n* Treatment with insulin, sulfonylureas, and GLP-1 receptor agonists, steroid use (oral, cutaneous, or parenteral), regular intake of melatonin, anticoagulation treatment that cannot be paused\n* Extreme early and extreme late chronotypes","75 Years",{"count":83,"type":23},30,[26],"The objective of this study is to investigate the impact of hypocaloric time-restricted eating (TRE) at different day times (early versus late TRE) on glucose metabolism and other cardiometabolic parameters in individuals with overweight and with normal, or impaired glucose metabolism (prediabetes and type 2 diabetes). In addition, the study aims to elucidate the molecular mechanisms underlying these effects.",[87,88,89],"Prediabetes","Type 2 Diabetes","Obesity &Amp; Overweight",[91,87,88,92,93,94,95,96,97,98],"Time-restricted eating","Chrononutrition","Glucose metabolism","Overweight","Obesity","Continuous glucose monitoring","TRE","Prevention and treatment of type 2 diabetes","2025-09-10",{"date":101,"type":42},"2025-09-12",{"date":103,"type":23},"2025-09-19",{"date":105,"type":23},"2028-02-28",{"name":48,"class":49},{"id":108,"slug":109,"hasResults":11,"nctId":110,"briefTitle":111,"officialTitle":112,"acronym":113,"eligibilityCriteria":114,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":81,"enrollmentInfo":115,"targetDuration":4,"studyType":24,"phases":116,"briefSummary":117,"conditions":118,"keywords":119,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":126,"lastUpdatePostDateStruct":127,"startDateStruct":129,"completionDateStruct":131,"leadSponsor":133,"locationsCount":50},"100545482","protein-rich-meals-to-control-glucose-100545482","NCT06382480","PROTeIn-rich Meals to Control Glucose","Meal Timing-based Strategies to Improve Glucose Metabolism in Prediabetes and Type 2 Diabetes","PROTIME","Inclusion Criteria:\n\n* Prediabetes (fasting blood sugar 100-125 mg\u002Fdl)\n* Diabetes type 2 (fasting blood sugar \\>126 mg\u002Fdl)\n* Overweight and obesity (BMI 25-50 kg\u002Fm2)\n\nExclusion Criteria:\n\n* Other diabetes types\n* Insulin treatment\n* Shift work\n* Weight changes \\>5% within past 3 months\n* Systemic glucocorticoid therapy\n* Systemic infections\n* Severe anemia\n* High blood pressure (\\>180\u002F110 mmHg)\n* Endocrinologic, liver and heart disorders\n* Immune diseases\n* Thyroid dysfunction\n* Heart attack or stroke\n* Cancer in the last 2 years\n* Eating disorders, food intolerance\u002Fallergy, addiction disorders, digestive disorders intestinal, liver, cardiovascular diseases\n* Hereditary or acquired coagulation disorders\n* Non-interruptible intake of blood thinners (anticoagulants)\n* Specific diets, intermittent fasting\n* Pregnancy or breastfeeding\n* Severe internal or psychiatric disorders or other conditions and drugs therapy that might influence the outcome of the study",{"count":83,"type":23},[26],"The overall aim is to identify the dietary pattern for prevention and treatment of type 2 diabetes. The specific aim of this pilot project is to compare effects of two diets with different diurnal distribution of carbohydrates and protein on the glucose metabolism in subjects with prediabetes and type 2 diabetes and its effects on inflammatory status.",[94,95,87,88],[120,94,95,87,88,121,92,122,123,124,125,98],"Glucose","Metabolism","Macronutrient composition","High-protein","High-carb","Isocaloric diet","2025-08-19",{"date":128,"type":42},"2025-08-26",{"date":130,"type":42},"2024-04-12",{"date":132,"type":23},"2027-02-28",{"name":48,"class":49},{"id":135,"slug":136,"hasResults":11,"nctId":137,"briefTitle":138,"officialTitle":139,"acronym":140,"eligibilityCriteria":141,"healthyVolunteers":17,"sex":142,"minAge":19,"maxAge":143,"enrollmentInfo":144,"targetDuration":4,"studyType":24,"phases":146,"briefSummary":147,"conditions":148,"keywords":152,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":156,"lastUpdatePostDateStruct":157,"startDateStruct":159,"completionDateStruct":161,"leadSponsor":163,"locationsCount":50},"100603208","decision-making-and-food-intake-100603208","NCT07133529","Decision-making and Food Intake","Decision-making and Food Intake (\"Buffet Study\")","Buffet","Inclusion Criteria:\n\n* Nulliparous women (age: 18-35 years) with a regular menstrual cycle (25-32 days)\n* Legally competent\u002FConsent to participate\n* Language proficiency in German (native speaker, fluent)\n* Physically and mentally healthy\n* Body mass index (BMI) of 18.5 - 30 kg\u002Fm2\n\nExclusion Criteria:\n\n* Current or use of hormonal contraceptives in the previous 6 months\n* Current use of hormonal intra-uterine devices (IUDs)\n* Previous or current pregnancy\n* Diagnosed psychological or metabolic disorder\n* Former or current illnesses of:\n\n  1. Brain or mind (including anxiety disorders, depression, eating disorders, personality disorders, alcohol, drugs or drug or non-substance dependence, neurological disorders other than occasional headache, psychiatric or neurological abnomalities)\n  2. Heart or blood circulation\u002Fcardiovascular disease (myocardial infarction, stroke, hypertension, hypotension, having a pacemaker)\n  3. Gastro-intestinal disorders (e.g. colon diseases, irritable bowel syndrome, Crohn's disease)\n  4. Endocrine disorders (e.g. thyroid disorders)\n  5. Other serious past or present medical conditions (for example, metabolic syndrome, diabetes)\n* Other serious health problems or current severe mental or physical stress.\n* Blood clotting disorder\n* Fear of drawing blood\n* Severe anemia\n* Previously diagnosed hypoglycemia episodes\n* Regular intake of medication (e.g. Antidepressant\u002Fanti-anxiety medication)\n* Blood donation within 4 weeks before the study appointment\n* Intake of anticoagulant medications\n* illegal drug consumption\n* smoking or nicotine consumption\n* extreme athletes\n* vegetarians or vegans or any other dietary restrictions due to allergies or intolerances\n* shift workers","FEMALE","35 Years",{"count":145,"type":23},45,[26],"The study will investigate how the expectation of food availability impacts the response to food cues, mood, interoceptive awareness, and consumption of food intake in healthy, naturally cycling women.",[29,149,30,150,151],"Hormones","Cognition","Food Intake",[153,154,155],"Decision-making","Food intake","Food uncertainty","2025-08-18",{"date":158,"type":42},"2025-08-21",{"date":160,"type":42},"2025-08-04",{"date":162,"type":23},"2026-07-31",{"name":48,"class":49},{"id":165,"slug":166,"hasResults":11,"nctId":167,"briefTitle":168,"officialTitle":169,"acronym":170,"eligibilityCriteria":171,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":172,"enrollmentInfo":173,"targetDuration":4,"studyType":24,"phases":174,"briefSummary":175,"conditions":176,"keywords":177,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":183,"lastUpdatePostDateStruct":184,"startDateStruct":186,"completionDateStruct":188,"leadSponsor":190,"locationsCount":50},"100555717","exogenous-ketones-and-behavior-100555717","NCT06515717","Exogenous Ketones and Behavior","Exogenous Ketones and Behavior (ExoKet)","ExoKet","Inclusion Criteria:\n\n* Consent to participate\n* Fluent in German\n* Physically healthy. No regular medication\n* No drug use 1 week prior to the study\n* BMI 18-31 kg\u002Fm2\n\nExclusion Criteria:\n\n* Former or current illnesses of:\n* Brain or mind (including eating disorders, personality disorders, alcohol, drugs or drug dependence, neurological disorders other than occasional headache; depression or anxiety disorder excluded)\n* Heart or blood circulation\n* Gastro-intestinal or endocrine disorders\n* Liver or kidney disorders\n* Electrolyte imbalance\n* Other serious past or present medical conditions (for example, metabolic syndrome, diabetes, cancer)\n* Pregnancy\n* Extreme athletes (\\>2h\u002Fday intense work-out; casual cycling or walking is ok)\n* Menopause (post menopause is ok)\n* Ketogenic diet, ketogenic supplement intake, intermittent fasting or calorie restricted diet during preceding 4 weeks of study participation\n* Fear of blood draw","45 Years",{"count":145,"type":23},[26],"The study will examine the effect of exogenous ketone ester on behavior and metabolism using Virtual Reality and computerizes behavioral tasks.",[29],[178,179,180,181,182],"ketones","human cognition","metabolism","anxiety","intervention","2024-07-26",{"date":185,"type":42},"2024-07-29",{"date":187,"type":23},"2024-07-18",{"date":189,"type":23},"2025-06-23",{"name":48,"class":49},{"id":192,"slug":193,"hasResults":11,"nctId":194,"briefTitle":195,"officialTitle":196,"acronym":4,"eligibilityCriteria":197,"healthyVolunteers":17,"sex":142,"minAge":19,"maxAge":198,"enrollmentInfo":199,"targetDuration":4,"studyType":24,"phases":201,"briefSummary":202,"conditions":203,"keywords":206,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":214,"lastUpdatePostDateStruct":215,"startDateStruct":216,"completionDateStruct":218,"leadSponsor":220,"locationsCount":50},"100555143","time-restricted-eating-and-cognition-100555143","NCT06508255","Time-restricted Eating and Cognition","Time-restricted Eating and Cognition (ChronoBEAT)","Inclusion Criteria:\n\n* right-handed\n* legally competent\n* physically and mentally healthy\n* BMI: 19-35 kg\u002Fm²\n* fluent in reading and speaking German\n\nExclusion Criteria:\n\n* weight change \\>5% of body weight during the last 3 months\n* pregnancy or breastfeeding\n* allergies (inclusion possible after consultation with study doctor)\n* history of cardiovascular disease (myocardial infarction, stroke, hypertension, hypotension) in the last year\n* severe psychiatric condition, including drug addiction and depression\n* impaired renal or liver function\n* dementia or other severely debilitating cognitive disease\n* history of or current eating disorders (e.g., Bulimia nervosa, Anorexia nervosa, Orthorexia nervosa, Binge-Eating disorder)\n* chronic diseases (e.g., Morbus Crohn, Colitis Ulcerosa)\n* metabolic disorders (e.g., metabolic syndrome, diabetes type 1 or 2)\n* hormonal imbalances (e.g., thyroid gland diseases)\n* consuming diseases (e.g., cancer, kachexie) in the last 2 years\n* surgical removal (partial removal) of the digestive organs (e.g., gastrectomy) or history of bariatric surgery\n* Autoimmune conditions or current infection\n* Blood clotting disorders (e.g., haemophilia)\n* Severe anemia\n* severe claustrophobia\n* blood donation four weeks prior to study entry\n* glucocorticoid therapy (oral)\n* anticoagulant medication (inclusion possible if medication can be paused)\n* taking medications that require regular eating\n* any medications or supplements known to affect sleep, circadian rhythms, immune activity or metabolism\n* taking weight loss, lipid or glucose-lowering medications (any medications that affects metabolism) i.e. metformin\n* pacemaker or other electrical implant\n* vaccination during the study course or in the two weeks' prior\n* immunosuppressive premedication\n* currently on a diet\u002Ffasting regime (or within 1 month)\n* professional athletes\n* nicotine consumption\n* drug abuse\n* alcohol consumption per week more than 14 beers (0,3l)\u002F wine (0,125l)\u002F sparkling wine (0,1l)\u002FSchnaps (4cl)\n* shift work\n* poor sleep quality (PSQI score \\> 10 at medical screening)\n* travel across more than one time zone one month before study or during study period\n* non-removable metallic implants\n* fear of blood draw","70 Years",{"count":200,"type":23},35,[26],"This study aims to investigate how time-restricted eating (TRE), more specifically TRE at different times (early vs late in the day), influences brain activity, behavior, decision-making, food intake, physical activity, the gut microbiome and metabolic processes. The study intervention procedure is a replication of that described in Peters et al. (2021).",[204,205],"Time Restricted Eating","Intermittent Fasting",[91,207,150,153,208,209,151,210,211,212,213],"Time-restricted feeding","Behaviour","Brain Activity","Diet","Microbiome","Sleep","Physical Activity","2024-07-17",{"date":187,"type":42},{"date":217,"type":42},"2024-05-17",{"date":219,"type":23},"2025-03",{"name":48,"class":49},""]