[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Goed Medisch Centrum\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":50},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":4},"100630717","phase-2-thumb-base-osteoarthritis-ultrasound-guided-platelet-rich-plasma-versus-placebo-injection-100630717",false,"NCT07491302","Thumb Base Osteoarthritis: Ultrasound-guided Platelet-rich Plasma Versus Placebo Injection","Thumb Base Osteoarthritis: Ultrasound-guided Platelet-rich Plasma Versus Placebo Injection (Thumbs-up Study)","Thumbs-up","Inclusion Criteria:\n\n* Age 18 or older\n* Patients with an Eaton-littler score of I, II or III\n* Patients with uni- or bilateral CMC-I osteoarthritis\n* Non-responders to conservative therapy i.e., hand therapy and immobilisation after 3 months\n\nExclusion Criteria:\n\n* Aged below 18\n* Patients with an Eaton-littler score of IV (STT arthrosis)\n* Surgical interventions of the CMC-I joint\n* A known articular systemic disease (e.g. rheumatoid arthritis) or additional hand osteoarthritis\u002F tenosynovitis or metabolic disease like diabetes mellitus\n* Patients with an infectious arthritis of CMC-I joint\n* A known psychiatric condition\n* Neuropathic chronic pain syndrome\n* Intra articular injection 6 months prior to inclusion\n* Smoking\n* Active use of statins","ALL","18 Years",{"count":20,"type":21},88,"ESTIMATED","INTERVENTIONAL",[24],"PHASE2","The goal of this clinical trial is to evaluate whether platelet-rich plasma (PRP) injections improve pain and function in adults with thumb base osteoarthritis (CMC-I OA).\n\nThe main questions it aims to answer are:\n\nDoes a PRP injection reduce pain compared to a placebo (saline) injection? Does PRP improve hand function, strength, and thumb mobility? What adverse events occur following PRP treatment?\n\nResearchers will compare PRP injections to a placebo injection (saline solution) to determine whether PRP is an effective treatment for CMC-I osteoarthritis.\n\nParticipants will:\n\nReceive a single ultrasound-guided injection of PRP or placebo (saline) in the CMC-I joint.\n\nAttend follow-up visits at 3, 6, 9, and 12 months for clinical assessments. Complete questionnaires on pain (VAS) and hand function (MHQ-DLV) at multiple time points.\n\nUndergo physical examinations (grip strength, pinch strength, thumb motion). Undergo ultrasound evaluations to assess joint characteristics.",[27],"Thumb Osteoarthritis",[29,30,31,32,33,34,35,36,37],"platelet-rich plasma","CMC-I joint","carpometacarpal joint osteoarthritis","Thumb base osteoarthritis","PRP injection","Placebo-controlled trial","Orthobiologics","Regenerative medicine","Ultrasound-guided injection","NOT_YET_RECRUITING","2026-04-03",{"date":41,"type":42},"2026-04-09","ACTUAL",{"date":44,"type":21},"2026-04",{"date":46,"type":21},"2027-06",{"name":48,"class":49},"Goed Medisch Centrum","OTHER",""]