[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Greg Bew\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":44},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":5},"100595453","phase-2-evaluating-benzoyl-peroxide-for-preventing-recurrence-of-hsv-1-outbreaks-with-rescue-crossover-option-100595453",false,"NCT07032649","Evaluating Benzoyl Peroxide for Preventing Recurrence of HSV-1 Outbreaks With Rescue Crossover Option","Double-Blind, Placebo-Controlled Clinical Trial Evaluating Benzoyl Peroxide for Preventing Recurrence of HSV-1 Outbreaks With Rescue Crossover Option","Inclusion Criteria:\n\nAdults aged 18-65 years, inclusive.\n\nDocumented history of at least two HSV-1 outbreaks per year.\n\nAbility and willingness to participate fully via telehealth (including video visits).\n\nMust provide informed consent to participate in the trial.\n\nAbility to comply with the trial protocol, including symptom reporting, topical cream application, and follow-up telehealth appointments.\n\nExclusion Criteria:\n\nCurrently pregnant or breastfeeding, or plans to become pregnant during the study period.\n\nKnown allergy or sensitivity to benzoyl peroxide or similar topical agents.\n\nCurrent participation in another clinical trial involving topical treatments.\n\nMedical conditions or skin conditions that could significantly interfere with topical treatment application or safety assessment.\n\nInability to effectively participate in telehealth visits or use video-based symptom verification.\n\nParticipants who, in the opinion of the investigator, are unlikely to comply fully with trial requirements or complete the 6-month follow-up period.","ALL","18 Years","65 Years",{"count":20,"type":21},100,"ESTIMATED","INTERVENTIONAL",[24],"PHASE2","Here's a clear, concise, and accurate \\*\\*brief summary\\*\\* suitable for your ClinicalTrials.gov PRS submission:\n\n* Brief Summary:\n\nThis randomized, double-blind, placebo-controlled clinical trial evaluates the effectiveness of topical Benzoyl Peroxide (10%) in preventing recurrent oral lesions caused by Herpes Simplex Virus Type 1 (HSV-1). Participants who experience frequent HSV-1 outbreaks will be randomly assigned to either Benzoyl Peroxide or placebo treatment. The trial will be conducted via telehealth visits, with treatment provided remotely. The primary objective is to determine whether Benzoyl Peroxide significantly delays or prevents HSV-1 lesion recurrence compared to placebo. Secondary outcomes include evaluating recurrence frequency, lesion severity, healing duration, and participant satisfaction. The trial also incorporates a rescue crossover step, allowing placebo-group participants who experience recurrence to receive active treatment. Results from this pilot study will inform the potential use of Benzoyl Peroxide as a novel, accessible topical treatment option for recurrent HSV-1 outbreaks.",[27],"HSV",[27,29,30,31],"HSV-1","HSV suppression","Herpes","NOT_YET_RECRUITING","2025-08-04",{"date":35,"type":36},"2025-08-05","ACTUAL",{"date":38,"type":21},"2026-01-01",{"date":40,"type":21},"2027-07",{"name":42,"class":43},"Greg Bew","INDUSTRY",""]