[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Guangzhou Psychiatric Hospital\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":75},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,47],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":31,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100538695","tdcs-interventions-for-subthreshold-depressive-symptoms-in-young-individuals-100538695",false,"NCT06294184","TDCS Interventions for Subthreshold Depressive Symptoms in Young Individuals.","Transcranial Direct Current Stimulation Interventions for Subthreshold Depressive Symptoms in Young Individuals.","Inclusion Criteria:\n\n* 1\\) Be between the ages of 12-25;\n* 2\\) is right-handed on the Edinburgh Handedness Inventory;\n* 3\\) 2-4 of the 9 depressive symptoms defined by the American Diagnostic and Statistical Manual of Diseases, Fifth Edition (DSM-5), lasting more than 1 week; or more than 5 depressive symptoms lasting more than 1 week but less than 2 weeks (i.e., not meeting criteria for a major depressive episode) (by DSM-5 Clinical Semi-Definitive Interview (K-SADS-PL) (Gilbody et al., 2017, JAMA);\n* 4\\) Hamilton Depression Scale (HAMD-24) 24 points≥ 8 points, \\< 24 points;\n* 5\\) Gender is not limited;\n* 6\\) Subjects and their families voluntarily participate and sign the informed consent form.\n\nExclusion Criteria:\n\n* 1\\) Individuals with the following diagnoses according to DSM-5: psychiatric disorders due to organic diseases, substance-related and addictive disorders, neurodevelopmental disorders, schizophrenia spectrum and other psychotic disorders, bipolar disorder (assessed by K-SADS-PL);\n* 2\\) Have two or more DSM-V-defined manic symptoms for 4 days but do not meet the criteria for hypomania or meet the DSM-V defined criteria for hypomanic symptoms for only 2-3 days;\n* 3\\) Severe or unstable physical illness;\n* 4\\) have a moderate or higher risk of suicide (as assessed by the Columbia Suicide Severity Scale);\n* 5\\) Received transcranial direct current stimulation in the past three months (continuous intervention time: \\>2 weeks);\n* 6\\) Contraindications to transcranial direct current stimulation, such as brain implants, personal or family history of epilepsy;\n* 7\\) Magnetic resonance scanning is contraindicated, such as in vivo metal implants.",true,"ALL","12 Years","25 Years",{"count":21,"type":22},150,"ESTIMATED","INTERVENTIONAL",[25],"NA","The purpose of this study is to assess the mechanisms of the effect of transcranial direct current stimulation (tDCS) in alleviating subthreshold depressive symptoms in young individuals, and individualized outcome prediction is carried out.",[28,29,30],"Subthreshold Depression","Young People","Transcranial Direct Current Stimulation",[32,33],"Resting-state brain functional network","Social emotion","RECRUITING","2024-12-07",{"date":37,"type":38},"2024-12-12","ACTUAL",{"date":40,"type":38},"2023-11-01",{"date":42,"type":22},"2025-12",{"name":44,"class":45},"Guangzhou Psychiatric Hospital","OTHER_GOV",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":16,"sex":17,"minAge":54,"maxAge":55,"enrollmentInfo":56,"targetDuration":4,"studyType":23,"phases":58,"briefSummary":59,"conditions":60,"keywords":63,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":46},"100566716","treating-loneliness-in-the-older-adult-with-depression-with-tdcs-100566716","NCT06658795","Treating Loneliness In The Older Adult With Depression With tDCS","Effects of Transcranial Direct Current Stimulation on Loneliness in Older Adults With Depression: A Randomized Controlled Trial","Inclusion Criteria:\n\n* High loneliness (UCLA Loneliness Scale \\> 43).\n* Diagnosis of major depressive disorder confirmed by the Structured Clinical Interview for DSM-5 Disorders.\n* absence of suicidal ideation (Hamilton Depression Scale item 3 score ≤ 1).\n\nExclusion Criteria:\n\n* Severe neurological diseases.\n* Bipolar disorder, schizophrenia, addiction, or impulse control disorders.\n* Contraindications for tDCS or MRI (e.g., metal implants).\n* Presence of suicidal ideation.","60 Years","80 Years",{"count":57,"type":22},180,[25],"High loneliness is prevalent among older adults and is a significant risk factor for major depression and low recovery rates in patients. Current interventions for loneliness are limited. Previous research has demonstrated a link between loneliness, negative social emotions, and reduced resting-state functional connectivity in the lateral prefrontal cortex (LPFC) and the default mode network (DMN). Transcranial direct current stimulation (tDCS) has shown promise in enhancing emotional regulation and connectivity, potentially alleviating loneliness in older adults with depression.",[61,62],"Major Depressive Disorder","Loneliness",[64,30,65,66],"Randomization Controlled Trial","Depression","loneliness","2024-10-23",{"date":69,"type":38},"2024-10-26",{"date":71,"type":22},"2024-10-29",{"date":73,"type":22},"2026-12-30",{"name":44,"class":45},""]