[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Gujranwala medical college District Headquarters Hospital, Gujranwala\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":75},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,49],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":31,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100620022","prp-plus-fractional-co-laser-for-acne-scars-100620022",false,"NCT07352215","PRP Plus Fractional CO₂ Laser for Acne Scars","Evaluating the Effectiveness of Platelet-Rich Plasma as an Adjunct to Fractional Carbon Dioxide Laser Therapy in Improving Facial Acne Scar Appearance: A Randomized Controlled Trial","PRPLT","Inclusion Criteria:Adults aged 18 to 40 years\n\nMale and female participants\n\nFitzpatrick skin types I to V\n\nPresence of moderate-to-severe acne scars\n\nWilling to undergo 3 treatment sessions and follow-up visits\n\nAble to provide informed consent -\n\nExclusion Criteria:Use of topical anti-acne medications in the past 1 month\n\nHistory of keloid formation or hypertrophic scarring\n\nActive acne or active skin inflammation at treatment area\n\nDiabetes mellitus\n\nPhotosensitive disorders (e.g., lupus, dermatomyositis)\n\nMelasma\n\nActive infections (e.g., Herpes simplex)\n\nRecent laser resurfacing or similar procedures\n\nOutdoor workers with high sun exposure\n\nVitiligo\n\nPregnancy or breastfeeding\n\nBleeding disorders or anticoagulant therapy\n\nUnrealistic expectations or inability to comply with follow-up\n\n\\-","ALL","18 Years","40 Years",{"count":21,"type":22},70,"ESTIMATED","INTERVENTIONAL",[25],"NA","This randomized controlled trial aims to evaluate whether adding platelet-rich plasma (PRP) to fractional CO₂ laser resurfacing improves the treatment of moderate-to-severe acne scars compared with laser alone. Seventy adults aged 18-40 years will be recruited from the Dermatology Department of Gujranwala Medical College Teaching Hospital. Participants will be randomly assigned to receive either fractional CO₂ laser combined with topical PRP or fractional CO₂ laser alone, with three treatment sessions delivered four weeks apart.\n\nThe primary outcome is the change in acne scar severity measured using the Goodman and Baron Quantitative Acne Scar Scale. Secondary outcomes include redness, edema, pain scores, and patient satisfaction assessed using Likert and numeric rating scales. The study is single-blinded, with patients unaware of treatment allocation. PRP will be prepared using a standardized double-spin centrifugation process. Data will be analyzed using appropriate statistical tests with a significance level of p \\\u003C 0.05. The study aims to determine whether PRP enhances laser efficacy, reduces side effects, and improves patient-reported outcomes.",[28,29,30],"Post-Acne Atrophic Scars","Carbon Dioxide Lasers","Platelet-Rich Plasma",[32,33,34,35],"Post-acne Scarring","Fractional CO₂ Laser","PRP Therapy","Skin Resurfacing","RECRUITING","2026-01-11",{"date":39,"type":40},"2026-01-20","ACTUAL",{"date":42,"type":40},"2025-10-31",{"date":44,"type":22},"2026-04-30",{"name":46,"class":47},"Gujranwala medical college District Headquarters Hospital, Gujranwala","OTHER",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":4,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":56,"minAge":57,"maxAge":58,"enrollmentInfo":59,"targetDuration":4,"studyType":23,"phases":61,"briefSummary":62,"conditions":63,"keywords":65,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":48},"100561754","comparison-of-efficacy-in-treating-breast-abscess-with-systemic-antibiotics-against-local-instillation-of-antibiotics-along-with-ultrasound-guided-aspiration-100561754","NCT06594276","Comparison of Efficacy in Treating Breast Abscess, With Systemic Antibiotics Against Local Instillation of Antibiotics Along With Ultrasound Guided Aspiration.","Effectiveness of Local Instillation of Antibiotics Compared to Systemic Antibiotics, as Adjunct to Ultrasound Guided Aspiration in the Management of Breast Abscess; a Randomized Controlled Trial","Inclusion Criteria:\n\n\\- Female gender Age range 14-60 years Lactating or non-lactating Clinical signs : erythema, tenderness, fever, fluctuation\n\nExclusion Criteria:\n\nPatients refusal Male gender Acute mastitis Malignant lesion (inflammatory carcinoma) Antibioma Draining abscess\u002FSinus Skin ulcers \u002F gangrene Diagnosed case of Tuberclosis H.I.V\n\n\\-","FEMALE","14 Years","60 Years",{"count":60,"type":22},104,[25],"Breast abscess, marked by localized collection of pus, frequently follows mastitis. Its prevalence soars up to 16% in the developing world. It usually presents in lactating mothers but also develops in prepubertal females as well. Conventionally it has been treated by surgical incision and drainage with antibiotic coverage, whether oral, intramuscular or intravenous. This approach requires hospital stay and general anesthesia but also have complications like scarring and disfigurement. With the financial and emotional impacts of this technique , surgeons have opted needle aspiration of breast abscess as a standardized treatment. It has been very successful in the management of breast abscess as it spares the patients from long hospital stays and the cosmetic complications. It may require to repeat the procedure till the complete resolution of symptoms which can be effectively assessed by the clinical symptoms of the patient like redness of the skin, pain, tenderness and ultrasonographical evidence of pus accumulation. Systemic antibiotics are still frequently administered for prophylactic and therapeutic purposes. It has been shown in previous studies that systemic antibiotics may not be as effective as deemed earlier due to local pathogenesis. The use of local antibiotics is not a novel concept but a firmly established fact , whether its the earliest sterilization of the operative field or treating open wounds and fractures . Studies have shown great effect of local use of antibiotics in different scenarios and this may help in limit the use of antibiotics and providing the systemic bypass with maximum local impact. In patients of breast abscess, along with ultrasound guided aspiration the inclusion of locally injecting the antibiotics may reduce the frequency of procedure till the absolute resolution of symptoms and also markedly decrease the failure rate of this technique , which usually resorts to the conventional incision and drainage.",[64],"Breast Abscess",[66],"treatment of breast abscess","2024-09-10",{"date":69,"type":40},"2024-09-19",{"date":71,"type":22},"2024-10",{"date":73,"type":22},"2025-04",{"name":46,"class":47},""]