[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Gulf Medical University\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":411},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,15,0,[8,46,73,100,122,147,177,201,225,262,288,310,335,361,384],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":31,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100645188","influence-of-re-evaluation-timing-after-phase-i-periodontal-therapy-on-clinical-and-periodontal-outcomes-100645188",false,"NCT07678125","Influence of Re-evaluation Timing After Phase I Periodontal Therapy on Clinical and Periodontal Outcomes.","Influence of Re-evaluation Timing After Phase I Periodontal Therapy on Clinical and Periodontal Outcomes. A Split-mouth Study","Inclusion Criteria:\n\n* Patients above 18 yrs\n* Patients that are systemically healthy\n* Patients diagnosed as Stage III or Stage IV Periodontitis\n* Patients willing to participate in the study and provide informed consent.\n* Patients with no recent history of periodontal therapy\n* Presence of ≥20 natural teeth\n\nExclusion criteria:\n\n* Patients with a history of medical conditions or diseases that may affect healing or periodontal tissues.\n* Patients who are pregnant\n* Patients on Drugs\u002Fmedication that may affect the periodontal tissue\n* Smokers or tobacco users\n* Patients that cannot complete the 12-week follow-up period",true,"ALL","21 Years","70 Years",{"count":21,"type":22},24,"ESTIMATED","INTERVENTIONAL",[25],"NA","Periodontal disease remains a highly prevalent chronic inflammatory condition affecting the supporting structures of the teeth and is a leading cause of tooth loss worldwide. Contemporary periodontal therapy is structured into sequential phases, with non-surgical periodontal therapy (NSPT) forming the cornerstone of initial management. Following this phase, re-evaluation of periodontal status is critical to determine treatment outcomes and guide further intervention, including surgical therapy if required (1,2).\n\nRe-evaluation phase serves multiple purposes: it allows assessment of tissue response to therapy, measurement of reductions in probing pocket depth (PPD), gains in clinical attachment level (CAL), and evaluation of patient compliance with oral hygiene practices. It also aids in identifying residual pockets or persistent inflammation that may necessitate additional treatment (1,3). Despite its clinical importance, the optimal timing of re-evaluation remains inconsistently defined in the literature (1). Generally, current literature utilizes a timing frame from 1-3 months; up to 9 months (3,4). Current clinical guidelines, including those from the European Federation of Periodontology (EFP), generally recommend assessing whether the end points have been achieved; no periodontal pockets ≥ 5mm with bleeding on probing and no pocket ≥ 6mm (5).\n\nEmerging evidence suggests that certain clinical improvements, particularly reductions in inflammation and bleeding on probing (BOP), may occur as early as 4 weeks following therapy, raising questions about whether earlier re-evaluation could be clinically beneficial (2,3). Early reassessment may allow for more timely identification of non-responding sites, enabling prompt intervention and potentially improving overall treatment outcomes. Conversely, other studies indicate that full periodontal healing and maturation of tissues may require longer periods, supporting delayed re-evaluation intervals (1,2,3).\n\nFurthermore, patient-related factors such as systemic health, smoking status, and baseline disease severity may influence healing dynamics and thus the appropriate timing for reassessment (1). The heterogeneity of these factors highlights the potential need for a more individualized approach to re-evaluation rather than a fixed universal timeframe.\n\nDespite these considerations, there is a notable lack of high-quality comparative studies directly evaluating short-term versus conventional re-evaluation intervals following NSPT. Most available studies focus on treatment outcomes rather than the timing of reassessment itself. This creates a significant gap in the literature, particularly regarding whether earlier re-evaluation could enhance clinical decision-making, improve patient outcomes, or optimize resource utilization in clinical practice.\n\nIn addition, with increasing emphasis on minimally invasive and patient-centered care, there is a growing need to refine periodontal treatment protocols to ensure efficiency without compromising effectiveness. Determining the optimal timing of re-evaluation could contribute to improved treatment planning, reduced disease progression, and enhanced long-term periodontal stability.\n\nTherefore, this study aims to address this gap by investigating the effectiveness and clinical implications of shorter re-evaluation intervals following periodontal therapy, compared to conventional timeframes.",[28,29,30],"Periodontal Diseases","Periodontitis (Stage 3)","Subgingival Debridement",[32],"periodontal disease","NOT_YET_RECRUITING","2026-06-25",{"date":36,"type":37},"2026-07-01","ACTUAL",{"date":39,"type":22},"2026-06-01",{"date":41,"type":22},"2027-02-15",{"name":43,"class":44},"Gulf Medical University","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":4,"eligibilityCriteria":52,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":53,"targetDuration":4,"studyType":23,"phases":55,"briefSummary":56,"conditions":57,"keywords":62,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":45},"100644844","evaluation-of-lateral-sinus-floor-elevation-using-xenograft-versus-l-prf-block-combined-with-xenograft-100644844","NCT07677007","Evaluation of Lateral Sinus Floor Elevation Using Xenograft Versus L-PRF Block Combined With Xenograft","Evaluation of Lateral Sinus Floor Elevation Using Xenograft Versus L-PRF Block Combined With Xenograft: A Randomized Controlled Clinical Trial","Inclusion Criteria:\n\n* Adults aged 21 years or older.\n* Partially edentulous posterior maxilla requiring implant-supported rehabilitation.\n* Residual bone height between 2 and 5 mm measured by CBCT.\n* Good oral hygiene and compliance with maintenance visits.\n* ASA I or II patients.\n* Signed informed consent.\n\nExclusion Criteria:\n\n* Uncontrolled systemic diseases.\n* Smoking more than 10 cigarettes\u002Fday.\n* Active sinus pathology or chronic sinusitis.\n* Previous sinus augmentation surgery.\n* Pregnancy or lactation.\n* Bisphosphonate therapy.\n* Immunocompromised patients.\n* History of head and neck radiotherapy",{"count":54,"type":22},30,[25],"Rehabilitation of the posterior maxilla with dental implants is frequently complicated by insufficient residual bone height resulting from alveolar ridge resorption and maxillary sinus pneumatization. Lateral sinus floor elevation has become a predictable and widely accepted procedure for increasing bone volume and enabling implant placement in severely atrophic posterior maxillary sites. The long-term success of this procedure is largely dependent on the grafting material used to maintain space beneath the elevated Schneiderian membrane and promote new bone formation.\n\nDeproteinized bovine bone mineral (DBBM), commonly known as xenograft, remains the most extensively documented grafting material for sinus augmentation due to its osteoconductive properties, volumetric stability, and favorable long-term clinical outcomes. However, xenografts are characterized by slow remodeling and prolonged persistence of residual graft particles, which may delay replacement by vital bone. Consequently, strategies to enhance the biological activity of xenografts and accelerate bone regeneration have become an area of considerable research interest.\n\nLeukocyte- and platelet-rich fibrin (L-PRF) is a second-generation autologous platelet concentrate containing a fibrin matrix enriched with platelets, leukocytes, cytokines, and growth factors including platelet-derived growth factor (PDGF), vascular endothelial growth factor (VEGF), and transforming growth factor-β (TGF-β). These biological mediators may enhance angiogenesis, accelerate wound healing, stimulate osteoblast proliferation, and improve bone regeneration.\n\nSeveral studies have demonstrated promising outcomes when L-PRF is used in sinus augmentation procedures. Mazor et al. reported successful bone formation and implant placement following sinus augmentation using PRF as the sole grafting material after six months of healing. Histological analysis demonstrated the formation of newly regenerated vital bone within the augmented sinus compartment.\n\nMore recently, Cortellini et al. conducted a randomized controlled trial comparing L-PRF block and DBBM in lateral sinus floor elevation. Although both techniques allowed successful implant placement after six months, differences in volumetric stability and graft remodeling were observed. The authors suggested that L-PRF-containing grafts may represent a biologically active alternative capable of enhancing healing while maintaining sufficient bone volume for implant placement.\n\nPichotano et al. further demonstrated that combining L-PRF with DBBM accelerated bone maturation and facilitated earlier implant placement when compared with xenograft alone. Histomorphometric findings revealed greater percentages of newly formed bone and reduced healing times in the L-PRF group.\n\nDespite these promising findings, the available evidence remains limited, and there is no clear consensus regarding whether the addition of L-PRF to xenografts results in clinically significant improvements in bone regeneration, volumetric maintenance, and implant site development. Therefore, a randomized controlled clinical trial comparing xenograft alone versus L-PRF block combined with xenograft during lateral sinus floor elevation is warranted.",[58,59,60,61],"Sinus Floor Augmentation","Maxillary Sinus Floor Elevation","Sinus Lift","Xenograft",[63],"maxillary sinus","RECRUITING","2026-06-24",{"date":67,"type":37},"2026-06-30",{"date":69,"type":37},"2026-01-01",{"date":71,"type":22},"2027-02-01",{"name":43,"class":44},{"id":74,"slug":75,"hasResults":11,"nctId":76,"briefTitle":77,"officialTitle":78,"acronym":4,"eligibilityCriteria":79,"healthyVolunteers":16,"sex":17,"minAge":80,"maxAge":19,"enrollmentInfo":81,"targetDuration":4,"studyType":23,"phases":83,"briefSummary":84,"conditions":85,"keywords":90,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":45},"100641584","comparison-of-eryag-assisted-laser-crown-lengthening-against-surgical-crown-lengthening-100641584","NCT07653802","Comparison of Er:YAG Assisted Laser Crown Lengthening Against Surgical Crown Lengthening","Comparison of Er:YAG Assisted Laser Crown Lengthening Against Surgical Crown Lengthening: a Longitudinal Study.","* Inclusion criteria:\n\n  1. Teeth indicated for crown lengthening procedure either in the maxillary or mandibular arch.\n  2. Patients in the age group of 18-75 years.\n* Exclusion criteria:\n\n  1. Patients with uncontrolled diabetes mellitus. Uncontrolled diabetes mellitus diagnosed with HbA1C ≥ 7% will be an exclusion criterion.\n  2. Smokers (considered as smoking ≥ 10 cigarettes\u002Fday)\n  3. Pregnant women\n  4. Patients with uncontrolled systemic diseases that may affect the healing of soft and hard tissues of the periodontium will be excluded.","20 Years",{"count":82,"type":22},26,[25],"Crown lengthening is a clinical procedure that involves reshaping the gingiva, and sometimes bone, in order to expose more of tooth's structure. The procedures is performed for both functional and aesthetic reasons. In certain instances, this procedure is performed to This procedure is commonly performed for both functional and aesthetic reasons, such as to prepare a tooth for a crown or to enhance the appearance of a smile. Traditional crown lengthening techniques typically involve surgical methods that can be invasive, leading to extended recovery times and postoperative discomfort in this study we compare traditional versus the laser aided crown lengthening to compare the periodontal parameters in both cases.",[86,87,88,89],"Crown Lengthening","Crown Lengthening Procedure With Ostectomy","Laser","Piezoelectric Technique",[91],"crown lengthening","2026-06-16",{"date":94,"type":37},"2026-06-17",{"date":96,"type":37},"2025-07-01",{"date":98,"type":22},"2026-09-30",{"name":43,"class":44},{"id":101,"slug":102,"hasResults":11,"nctId":103,"briefTitle":104,"officialTitle":105,"acronym":4,"eligibilityCriteria":106,"healthyVolunteers":16,"sex":17,"minAge":80,"maxAge":19,"enrollmentInfo":107,"targetDuration":4,"studyType":23,"phases":108,"briefSummary":109,"conditions":110,"keywords":4,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":116,"lastUpdatePostDateStruct":117,"startDateStruct":118,"completionDateStruct":120,"leadSponsor":121,"locationsCount":45},"100641906","evaluation-of-multilayered-prf-in-comparison-with-connective-tissue-graft-by-sohn-ponchos-technique-on-peri-implant-mucosal-enhancement-in-the-esthetic-zone-100641906","NCT07649239","Evaluation of Multilayered PRF in Comparison With Connective Tissue Graft by Sohn Poncho's Technique on Peri-implant Mucosal Enhancement in the Esthetic Zone","Evaluation of Multilayered PRF in Comparison With Connective Tissue Graft by Sohn Poncho's Technique on Peri-implant Mucosal Enhancement in the Esthetic Zone. A Randomized Clinical Trial","-Inclusion Criteria: Patients with single bounded missing tooth in the esthetic zone Patients in the age group of 21-65 years Patients having good oral hygiene (mean plaque score of \\\u003C 25%) and with stable periodontal status.\n\n-Exclusion Criteria: Smokers patients Patients with poor maintenance of oral hygiene, as determined by a mean plaque score of ≥ 25% despite efforts by the clinician to improve oral hygiene maintenance.\n\nPatients with medically compromised conditions like uncontrolled diabetes mellitus or any systemic diseases that may result in compromised hard and soft tissue healing.",{"count":82,"type":22},[25],"An effective biological seal is crucial for protecting and supporting dental implants, particularly in the anterior region for the desired esthetic outcome.PRF membrane and CTG has been utilized to improve peri-implant soft tissue thickness and increase the width of keratinized tissue around dental implants. The stability of the PRF membrane is maintained by securing it with the healing abutment of the implant. While a few longitudinal studies have assessed the benefits of using PRF membrane with Sohn's Poncho technique in the posterior region, its effectiveness in the anterior region of the mouth remains to be evaluated.",[111,112,113,114,115],"Soft Tissue","Peri-Implant Health","Soft Tissue Augmentation at Dental Implants","Connective Tissue Graft","PRF","2026-06-12",{"date":92,"type":37},{"date":119,"type":37},"2026-01-10",{"date":71,"type":22},{"name":43,"class":44},{"id":123,"slug":124,"hasResults":11,"nctId":125,"briefTitle":126,"officialTitle":127,"acronym":4,"eligibilityCriteria":128,"healthyVolunteers":11,"sex":17,"minAge":129,"maxAge":130,"enrollmentInfo":131,"targetDuration":4,"studyType":23,"phases":133,"briefSummary":134,"conditions":135,"keywords":137,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":140,"lastUpdatePostDateStruct":141,"startDateStruct":143,"completionDateStruct":145,"leadSponsor":146,"locationsCount":45},"100632926","effectiveness-of-extra-corporeal-shockwave-diathermy-in-the-management-of-upper-limb-function-patients-with-stroke-100632926","NCT07520032","Effectiveness of Extra-corporeal Shockwave Diathermy in the Management of Upper Limb Function Patients With Stroke.","Effectiveness of Extra-corporeal Shockwave Diathermy in the Management of Upper Limb Function Patients With Stroke: Randomized Controlled Trial.","Inclusion criteria:\n\n1. Diagnosed as 1st stroke incidence 6 months back\n2. Both male and female\n3. Age 25 to 65 years\n4. the ability to follow verbal instructions\n5. Modified Ashworth Scale score 1-4\n\nExclusion criteria:\n\n1. Recurrent stroke.\n2. Severe contractures or deformities of upper extremity.\n3. Chronic pain affecting upper extremity function.\n4. malignant tumor, pacemakers, infection","18 Years","65 Years",{"count":132,"type":22},50,[25],"Stroke is a leading cause of death and disability worldwide. A major complication of stroke is spasticity, marked by increased muscle tone and impaired movement. It affects majority stroke patients and complicates rehabilitation, affecting the upper limb function of survivors.\n\nWhile traditional treatments like oral medications and botulinum toxin injections offer some relief, they have notable limitations, causing the need for novel, non-invasive approaches. Extracorporeal shock wave therapy (ESWT), which uses acoustic waves for regeneration and neuromodulation, has shown promise in reducing spasticity with minimal side effects, though its precise mechanisms and ideal protocols need further study. Current evidence supports ESWT's efficacy and safety, often matching established treatments, but gaps remain regarding standardized application and long-term functional outcomes, highlighting the need for more robust research.",[136],"Stroke",[138,139],"upperlimb funciton","extracarporal shockwave therapy","2026-04-06",{"date":142,"type":37},"2026-04-09",{"date":144,"type":37},"2025-10-30",{"date":67,"type":22},{"name":43,"class":44},{"id":148,"slug":149,"hasResults":11,"nctId":150,"briefTitle":151,"officialTitle":152,"acronym":4,"eligibilityCriteria":153,"healthyVolunteers":16,"sex":17,"minAge":129,"maxAge":4,"enrollmentInfo":154,"targetDuration":4,"studyType":23,"phases":156,"briefSummary":157,"conditions":158,"keywords":162,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":169,"lastUpdatePostDateStruct":170,"startDateStruct":172,"completionDateStruct":174,"leadSponsor":176,"locationsCount":45},"100628985","peri-implant-hard-and-soft-tissue-changes-after-immediate-implant-placement-with-socket-shield-and-immediate-restoration-versus-early-implant-placement-in-the-esthetic-zone-100628985","NCT07468760","Peri-Implant Hard and Soft Tissue Changes After Immediate Implant Placement With Socket Shield and Immediate Restoration Versus Early Implant Placement in the Esthetic Zone","Evaluation of Peri-implant Hard And Soft Tissues Changes Between Immediate Implant Placement With Socket Shield Technique and Immediate Restoration Versus Early Type II Implant Placement in The Esthetic Zone - A Randomized Controlled Clinical Trial","Inclusion Criteria:\n\n1. Adults aged 18 years or older\n2. Patients presenting with a single non-restorable tooth in the esthetic zone indicated for extraction and implant replacement\n3. Presence of a thin buccal bone plate (\\\u003C1 mm)\n4. Adequate bone volume to allow implant placement in a prosthetically ideal position\n5. Intact socket walls following tooth extraction\n6. Ability to achieve primary implant stability ≥35 Ncm at the time of implant placement\n7. Patients willing to participate in the study and able to provide written informed consent\n\nExclusion Criteria:\n\n1. History of systemic diseases that may affect bone healing\n2. Use of medications that may influence bone metabolism (e.g., bisphosphonates)\n3. Smoking within the past 5 years\n4. Presence of acute infection at the surgical site or adjacent teeth\n5. Teeth with vertical or subcrestal horizontal root fractures on the buccal aspect\n6. Presence of internal or external root resorption\n7. Severe periodontal destruction at the implant site",{"count":155,"type":22},42,[25],"This randomized controlled clinical trial aims to compare peri-implant hard and soft tissue dimensional changes following immediate implant placement with the socket shield technique and immediate restoration versus early type II implant placement with contour graft in the esthetic zone. The primary outcome is the Pink Esthetic Score (PES), while secondary outcomes include mid-facial mucosal recession, radiographic vertical and horizontal buccal bone remodeling, and patient satisfaction after 12 months.",[159,160,161],"Tooth Loss in the Anterior Maxilla","Alveolar Bone Resorption","Partial Edentulism of the Maxilla",[163,164,165,166,167,168],"Socket Shield Technique","Immediate Implant Placement","Early Implant Placement","Pink Esthetic Score","Partial Extraction Therapy","Buccal Bone Remodeling","2026-03-09",{"date":171,"type":37},"2026-03-13",{"date":173,"type":22},"2026-03-30",{"date":175,"type":22},"2027-05-30",{"name":43,"class":44},{"id":178,"slug":179,"hasResults":11,"nctId":180,"briefTitle":181,"officialTitle":182,"acronym":4,"eligibilityCriteria":183,"healthyVolunteers":16,"sex":17,"minAge":129,"maxAge":4,"enrollmentInfo":184,"targetDuration":4,"studyType":23,"phases":186,"briefSummary":187,"conditions":188,"keywords":192,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":169,"lastUpdatePostDateStruct":197,"startDateStruct":198,"completionDateStruct":199,"leadSponsor":200,"locationsCount":45},"100628984","influence-of-implant-insertion-depth-on-peri-implant-bone-changes-around-short-implants-100628984","NCT07468747","Influence of Implant Insertion Depth on Peri-implant Bone Changes Around Short Implants","\"Influence Of Crestal Versus Subcrestal Implant Placement Levels On Peri-Implant Health And Radiographic Bone Changes Around Short Implants: A Randomized Controlled Clinical Trial.\"","Inclusion Criteria:\n\n1. Adults aged 18 years or older requiring dental implant therapy for replacement of a missing tooth in the posterior maxilla or mandible.\n2. Presence of sufficient bone volume to receive a short dental implant without the need for bone augmentation procedures.\n3. Patients in good general health or with controlled systemic conditions that do not contraindicate implant surgery.\n4. oral hygiene, defined as a plaque score ≤25%.\n5. Presence of healthy or treated periodontal tissues prior to implant placement.\n6. Patients willing and able to return for follow-up visits at 3, 6, and 12 months.\n7. Patients who provide written informed consent to participate in the study.\n\nExclusion Criteria:\n\n1. Patients with uncontrolled systemic diseases (e.g., uncontrolled diabetes mellitus, immunosuppressive disorders).\n2. History of radiotherapy in the head and neck region.\n3. Patients currently receiving bisphosphonate therapy or other medications affecting bone metabolism.\n4. Active periodontal disease or untreated oral infections.\n5. Heavy smokers (≥10 cigarettes per day).\n6. Presence of parafunctional habits such as severe bruxism or clenching.\n7. Patients requiring simultaneous bone grafting or sinus augmentation at the implant site.\n8. Pregnant or lactating women.\n9. Patients unable or unwilling to comply with the study protocol or follow-up schedule.",{"count":185,"type":22},58,[25],"Dental implants are widely used to replace missing teeth and restore oral function and aesthetics. One of the key factors affecting the long-term success of dental implants is the stability of the bone surrounding the implant, particularly the crestal bone around the implant neck. Implant insertion depth relative to the alveolar crest may influence peri-implant tissue health and marginal bone remodeling.\n\nThis randomized controlled clinical trial aims to evaluate the influence of implant placement depth on peri-implant health and radiographic bone changes around short dental implants placed using guided surgical protocol. All implants will be placed using the Bicon Implant System following computer-guided implant planning and surgical guide fabrication to ensure precise implant positioning.\n\nParticipants requiring implant therapy will be randomly allocated into two groups. In the test group, implants will be placed 2 mm below the crestal bone level (subcrestal placement). In the control group, implants will be placed at the crestal bone level (crestal placement). Implant placement will be performed using guided implant surgery to standardize surgical positioning and minimize variability in implant angulation and depth.\n\nClinical parameters related to peri-implant health, including Modified Plaque Index, Implant Mucosal Index, Peri-implant Mucosal Tissue Index and Probing Depth during follow-up visits at 3, 6 and 12 months. In addition, standardized radiographic examinations will be performed to measure peri-implant Crestal bone level changes at 12 months.\n\nThe primary objective of this study is to determine whether subcrestal implant placement (2 mm below the bone crest) results in improved preservation of peri-implant crestal bone compared with crestal implant placement. Secondary outcomes will include assessment of peri-implant soft tissue health and overall implant stability.\n\nThe findings of this study may help clarify the optimal implant insertion depth for short implants placed using guided surgery and may contribute to improving long-term implant success and peri-implant tissue stability.",[189,190,191],"Tooth Loss","Edentulism","Peri-implant Bone Loss",[193,194,195,112,196],"Dental Implants","Short Implants","Subcrestal Implant Placement","Radiographic Bone Changes",{"date":171,"type":37},{"date":173,"type":22},{"date":175,"type":22},{"name":43,"class":44},{"id":202,"slug":203,"hasResults":11,"nctId":204,"briefTitle":205,"officialTitle":206,"acronym":4,"eligibilityCriteria":207,"healthyVolunteers":16,"sex":17,"minAge":129,"maxAge":4,"enrollmentInfo":208,"targetDuration":4,"studyType":23,"phases":210,"briefSummary":211,"conditions":212,"keywords":215,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":169,"lastUpdatePostDateStruct":221,"startDateStruct":222,"completionDateStruct":223,"leadSponsor":224,"locationsCount":45},"100628986","effect-of-individually-trained-oral-prophylaxis-itop-on-gingival-health-in-orthodontic-patients-100628986","NCT07468773","Effect of Individually Trained Oral Prophylaxis (iTOP) on Gingival Health in Orthodontic Patients","Effect of Individually Trained Oral Prophylaxis (iTOP) Versus Conventional Oral Hygiene Instruction on Gingival Health in Orthodontic Patients Using Calibrated Interdental Brushes: A Randomized Controlled Clinical Trial","Inclusion Criteria:\n\n1. Adults aged 18 years or older\n2. Patients undergoing fixed orthodontic treatment\n3. Diagnosis of biofilm-induced gingivitis\n4. Presence of interdental spaces suitable for calibrated interdental brush use\n5. Ability and willingness to perform oral hygiene procedures and attend follow-up visits\n6. Provision of written informed consent\n\nExclusion Criteria:\n\n1. Presence of systemic diseases affecting gingival health (e.g., uncontrolled diabetes)\n2. Use of medications known to influence gingival conditions (e.g., phenytoin, cyclosporine, calcium channel blockers)\n3. History of chemotherapy or radiotherapy in the head and neck region\n4. Current smokers\n5. Pregnant or lactating women\n6. Patients with physical or cognitive disabilities affecting oral hygiene performance\n7. Use of additional professional oral hygiene interventions or antimicrobial mouth rinses during the study period",{"count":209,"type":22},60,[25],"This randomized controlled clinical trial aims to evaluate the effectiveness of individualized oral hygiene education using the Individually Trained Oral Prophylaxis (iTOP) method compared with conventional oral hygiene instruction using model demonstration and video-based education in orthodontic patients diagnosed with gingivitis.\n\nSixty orthodontic patients underwent professional mechanical plaque removal and received oral hygiene instruction using calibrated interdental brushes. Participants were randomly assigned to either the iTOP training group or the conventional education group.\n\nClinical outcomes including Approximal Plaque Index (API), Gingival Index (GI), and Full Mouth Bleeding Score (FMBS) were assessed at baseline and after three months to determine the effectiveness of the educational interventions on plaque control and gingival health.",[213,214],"Gingivitis","Orthodontic Treatment",[216,217,218,219,220],"Interdental Brushes","iTOP","Oral Hygiene Education","Approximal Plaque Index","Plaque Control",{"date":171,"type":37},{"date":173,"type":22},{"date":98,"type":22},{"name":43,"class":44},{"id":226,"slug":227,"hasResults":11,"nctId":228,"briefTitle":229,"officialTitle":230,"acronym":4,"eligibilityCriteria":231,"healthyVolunteers":16,"sex":17,"minAge":129,"maxAge":232,"enrollmentInfo":233,"targetDuration":4,"studyType":23,"phases":234,"briefSummary":235,"conditions":236,"keywords":239,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":254,"lastUpdatePostDateStruct":255,"startDateStruct":257,"completionDateStruct":259,"leadSponsor":261,"locationsCount":4},"100622527","isokinetic-exercise-combined-with-blood-flow-restriction-high-load-vs-low-load-training-100622527","NCT07384780","Isokinetic Exercise Combined With Blood Flow Restriction: High-Load Vs Low-Load Training","Isokinetic Exercise Combined With Blood Flow Restriction: High-Load Vs Low-Load Training : A Randomized Controlled Trial in Post-ACL Reconstruction Populations","Inclusion Criteria:\n\nFor ACLR group:\n\n•Isolated unilateral ACL reconstruction 8-16 weeks post-surgery with medical clearance for moderate to high resistance training.\n\nFor control group(healthy population):\n\n* Healthy adults with no musculoskeletal pathology.\n\nExclusion Criteria:\n\n* History of cardiovascular or metabolic diseases\n* Deep vein thrombosis\n* Coagulopathy\n* Hypertension\n* Skin lesions or infections at the site of BFR cuff administration\n* Neuromuscular disorders\n* Non-clearance from the surgeon or physiotherapist or resistance training.","35 Years",{"count":209,"type":22},[25],"The goal of this clinical trial is to see which type of strengthening exercise with a tight band (blood flow restriction) helps people recover better after ACL reconstruction. The study includes adults after ACL surgery who are doing physiotherapy to rebuild thigh muscle strength and knee function.\n\nThe main questions are:\n\n* Does heavy strengthening with blood flow restriction improve thigh strength, knee function, and daily activities more than light strengthening with blood flow restriction after ACL surgery?\n* Can light strengthening with blood flow restriction give similar benefits to heavy strengthening while putting less strain on the knee?\n\nResearchers will compare a heavy-exercise program plus blood flow restriction to a light-exercise program plus blood flow restriction to see which gives better strength and functional improvements.\n\nParticipants will:\n\n* Come for supervised physiotherapy sessions and do knee exercises on a machine, using either heavy or light loads while a cuff on the thigh gently squeezes to reduce blood flow.\n* Have their leg strength, and knee questionnaires checked several times during the study.",[237,238],"ACL Reconstruction","ACL Repair",[240,241,242,243,237,244,245,246,247,248,249,250,251,252,253],"blood flow restriction training ACL","Blood flow restriction","ACL Rehab","ACLR","BFR therapy anterior cruciate ligament reconstruction","BFR therapy ACLR","BFR Therapy","low-load versus high-load BFR knee rehabilitation","isokinetic strength training after ACL surgery","physiotherapy rehabilitation protocol ACL isokinetic BFR","Knee physiotherapy","ACL","ACL Isokinetic","ACLٍ Isokinetic","2026-02-03",{"date":256,"type":37},"2026-02-05",{"date":258,"type":22},"2026-02",{"date":260,"type":22},"2026-06",{"name":43,"class":44},{"id":263,"slug":264,"hasResults":11,"nctId":265,"briefTitle":266,"officialTitle":267,"acronym":4,"eligibilityCriteria":268,"healthyVolunteers":16,"sex":269,"minAge":129,"maxAge":270,"enrollmentInfo":271,"targetDuration":4,"studyType":23,"phases":273,"briefSummary":274,"conditions":275,"keywords":277,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":281,"lastUpdatePostDateStruct":282,"startDateStruct":284,"completionDateStruct":285,"leadSponsor":287,"locationsCount":45},"100622700","core-stability-training-with-balloon-breathing-on-balance-and-performance-in-football-players-100622700","NCT07387029","Core Stability Training With Balloon Breathing on Balance and Performance in Football Players","Core Stability Training With Ball and Balloon Exercise on Dynamic Balance, Hop Performance, and Core Endurance in Professional Football Players - A Randomized Clinical Trial","Inclusion Criteria:\n\n* Male professional football players aged 18 to 35 years\n* Currently playing at club level\n* Free from musculoskeletal injury for at least 6 months prior to enrollment\n* Willing to participate and provide written informed consent\n* Able to participate in regular football training and exercise programs\n\nExclusion Criteria:\n\n* Current musculoskeletal injury or pain affecting training or performance\n* History of lower limb or spinal surgery within the past year\n* Any neurological, cardiovascular, or respiratory condition that limits physical activity\n* Participation in any structured core stability or breathing training program within the past 3 months\n* Female players","MALE","28 Years",{"count":272,"type":22},68,[25],"Football players require good core strength and balance to perform well and reduce the risk of injury. The muscles of the trunk and diaphragm play an important role in maintaining stability, posture, and movement control during sports activities.\n\nThis randomized controlled trial aims to evaluate the effects of core stability training combined with balloon breathing exercises on dynamic balance, hop performance, and core endurance in professional football players. Balloon breathing exercises are designed to improve diaphragmatic breathing and trunk muscle activation.\n\nEligible football players will be randomly assigned to one of two groups: one group will receive core stability training combined with balloon breathing exercises along with regular football training, while the other group will receive core stability training with regular football training only. The intervention will be performed three times per week for eight weeks under the supervision of a physiotherapist.\n\nOutcome measures, including dynamic balance, hop performances, core endurance, and maximum voluntary ventilation (MVV), will be assessed at baseline, during the intervention, at the end of the program, and at a three-month follow-up. The findings of this study may help improve training strategies aimed at enhancing performance and reducing injury risk in football players.",[276],"Dynamic Balance, Hop Performance and Maximum Voluntary Ventilation (MVV) in Professional Football Players",[278,279,280],"Dynamic balance","Diaphragmatic breathing","Core stability","2026-01-28",{"date":283,"type":37},"2026-02-04",{"date":258,"type":22},{"date":286,"type":22},"2026-08",{"name":43,"class":44},{"id":289,"slug":290,"hasResults":11,"nctId":291,"briefTitle":292,"officialTitle":293,"acronym":294,"eligibilityCriteria":295,"healthyVolunteers":11,"sex":17,"minAge":129,"maxAge":130,"enrollmentInfo":296,"targetDuration":4,"studyType":23,"phases":298,"briefSummary":299,"conditions":300,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":302,"lastUpdatePostDateStruct":303,"startDateStruct":305,"completionDateStruct":307,"leadSponsor":309,"locationsCount":45},"100608074","effect-of-passive-versus-active-aquatic-therapy-compared-with-conventional-physiotherapy-for-chronic-low-back-pain-100608074","NCT07196826","Effect of Passive Versus Active Aquatic Therapy Compared With Conventional Physiotherapy for Chronic Low Back Pain","Effect of Passive Versus Active Aquatic Therapy Over Conventional Physiotherapy in Patients With Chronic Low Back Pain - A Randomized Crossover Trial","AQUA-LBP","Inclusion Criteria:\n\n* Adults aged 18 to 65 years.\n* Diagnosed with nonspecific chronic low back pain (duration \\>3 months).\n* Capable of attending sessions and providing written informed consent. -\n\nExclusion Criteria:\n\n* Acute low back pain or red flags (fractures, malignancy, infection).\n* Recent spinal surgery (\\\u003C6 months).\n* Neurological disorders affecting balance or gait.\n* Cardiopulmonary conditions contraindicating immersion.\n* Pregnancy.",{"count":297,"type":22},12,[25],"This study is designed to help people with chronic low back pain, which is pain in the lower back that persists for more than three months and can affect daily life, including sitting, standing, walking, lifting, and other routine activities. Chronic low back pain can also impact work, mood, and overall quality of life, making it important to find effective rehabilitation methods that reduce pain and improve function.\n\nThe study compares the effects of three different rehabilitation approaches:\n\n1. Active aquatic therapy - participants perform exercises in water where they actively move their back, core, and legs. The water helps support the body and reduces stress on the spine, allowing safer and easier movement. This approach aims to improve strength, flexibility, core stability, and overall function.\n2. Passive aquatic therapy - participants receive assisted movements in water guided by a trained physiotherapist. This gentle method helps increase spinal mobility, reduces stiffness, promotes relaxation, and can relieve pain without placing stress on the lower back.\n3. Conventional physiotherapy - participants perform standard exercises on land, including stretching, strengthening, and core stabilization exercises. All sessions are supervised by licensed physiotherapists to ensure exercises are done safely and effectively.\n\nParticipants will be randomly assigned to one of the three groups. Each intervention lasts 4 weeks, with multiple sessions each week. All sessions are supervised to provide proper guidance, ensure safety, and adapt exercises to each participant's needs.\n\nBefore starting therapy, participants' pain levels, core strength, flexibility, spinal mobility, and ability to perform daily activities will be measured using simple and understandable assessments. These measures will be repeated at the end of the 4-week intervention to evaluate improvements and compare the effectiveness of each rehabilitation approach.\n\nThe study is safe and non-invasive. No surgery, injections, or medications are involved. Participants' personal information is kept confidential, and all collected data will be used solely for research purposes.\n\nBy participating in this study, patients may benefit from structured, supervised rehabilitation that could help reduce pain, improve mobility and strength, enhance balance and core stability, and increase confidence in performing daily activities. Patients' feedback during sessions will also help researchers understand their experiences and preferences, which can improve future treatment recommendations.\n\nThe results of this study will help patients, families, physiotherapists, and healthcare providers understand which type of rehabilitation is most effective for chronic low back pain. This information can guide treatment decisions, improve individualized care plans, and support patients in returning to normal activities with less discomfort and greater independence.\n\nOverall, the study aims to provide clear, practical information about rehabilitation options for chronic low back pain, improve functional outcomes, and enhance quality of life. Participants' contributions will help generate evidence that may benefit others with similar conditions in the future, while also receiving safe and professional care throughout the study.",[301],"Chronic Low Back Pain","2025-12-10",{"date":304,"type":37},"2025-12-18",{"date":306,"type":22},"2026-02-20",{"date":308,"type":22},"2026-08-10",{"name":43,"class":44},{"id":311,"slug":312,"hasResults":11,"nctId":313,"briefTitle":314,"officialTitle":315,"acronym":4,"eligibilityCriteria":316,"healthyVolunteers":11,"sex":17,"minAge":317,"maxAge":318,"enrollmentInfo":319,"targetDuration":4,"studyType":23,"phases":320,"briefSummary":321,"conditions":322,"keywords":324,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":327,"lastUpdatePostDateStruct":328,"startDateStruct":330,"completionDateStruct":332,"leadSponsor":334,"locationsCount":4},"100606754","comparing-neural-mobilization-and-traditional-physiotherapy-in-plantar-fasciitis-patients-100606754","NCT07179666","Comparing Neural Mobilization and Traditional Physiotherapy in Plantar Fasciitis Patients","Effectiveness of Neural Mobilization in Patients With Planter Fasciitis: A Pilot Study","Inclusion Criteria:\n\n* Participants will be selected within the age range of 19 to 40 years\n* Meet the diagnostic criteria for plantar fasciitis, including symptoms of first-step pain in the morning and heel pain after long periods of standing, confirmed through clinical examination.\n\nExclusion Criteria:\n\n* Individuals will be omitted from the study if they have undergone foot or ankle or foot surgery during the prior 12 months\n* The presence of severe osteoarthritis, diabetic foot ulcers, or neuropathy","19 Years","40 Years",{"count":297,"type":22},[25],"To evaluate the short-term effectiveness of neural mobilization targeting the posterior tibial nerve compared to traditional physiotherapy in cases diagnosed with plantar fasciitis, a pilot study will be conducted on 12 patients who will have been diagnosed with plantar fasciitis. Participants will be randomly divided into either the neural mobilization group or the conventional physiotherapy group, and all will receive three weeks of structured treatment. Results will be evaluated using techniques that will measure plantar pressure with Algometry, Foot Function Index (FFI) scores, and the Foot Health Status Questionnaire (FHSQ). Differences before and after treatment will be tested within the group using paired t-tests, and others will be examined between the groups with independent t-tests.",[323],"Plantar Fasciitis",[325,326],"neural moblization","conventional treatment","2025-09-11",{"date":329,"type":37},"2025-09-18",{"date":331,"type":22},"2025-09-12",{"date":333,"type":22},"2025-12-15",{"name":43,"class":44},{"id":336,"slug":337,"hasResults":11,"nctId":338,"briefTitle":339,"officialTitle":340,"acronym":341,"eligibilityCriteria":342,"healthyVolunteers":11,"sex":17,"minAge":318,"maxAge":130,"enrollmentInfo":343,"targetDuration":4,"studyType":23,"phases":345,"briefSummary":346,"conditions":347,"keywords":349,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":353,"lastUpdatePostDateStruct":354,"startDateStruct":356,"completionDateStruct":358,"leadSponsor":360,"locationsCount":45},"100574770","effect-of-shoulder-symptom-modification-procedure-ssmp-in-managing-patients-with-frozen-shoulder-100574770","NCT06763601","Effect of Shoulder Symptom Modification Procedure (SSMP) in Managing Patients with Frozen Shoulder","Effect of Shoulder Symptom Modification Procedure (SSMP) in Managing Patients with Frozen Shoulder: a Pilot Study","SSMP","Inclusion Criteria:\n\n* • Diagnosis of adhesive capsulitis confirmed by a healthcare professional.\n\n  * Scores more than 2 in adhesive capsulitis scale\n  * Range of motion affected in capsular pattern\n  * Age between 40-65 years.\n  * Willingness to participate by signing informed consent\n\nExclusion Criteria:\n\n* Having any history of shoulder dislocation\n* Humerus fractures or trauma\n* Diagnosed with any sort of cancer\n* History of cardiovascular disease",{"count":344,"type":22},36,[25],"the study is about intervention to patient with frozen shoulder to help patients improve function and shoulder disability , reduce pain and improve range of motion, the main aim of this study is to find out which treatment intervention SSMP , MWM and sham mobilization give effective results",[348],"Frozen Shoulder",[341,350,351,352],"MWM","sham mobilization","frozen shoulder","2025-01-07",{"date":355,"type":37},"2025-01-08",{"date":357,"type":37},"2025-01-01",{"date":359,"type":22},"2025-05-16",{"name":43,"class":44},{"id":362,"slug":363,"hasResults":11,"nctId":364,"briefTitle":365,"officialTitle":366,"acronym":4,"eligibilityCriteria":367,"healthyVolunteers":16,"sex":17,"minAge":80,"maxAge":368,"enrollmentInfo":369,"targetDuration":4,"studyType":23,"phases":371,"briefSummary":373,"conditions":374,"keywords":4,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":376,"lastUpdatePostDateStruct":377,"startDateStruct":379,"completionDateStruct":381,"leadSponsor":383,"locationsCount":45},"100567711","phase-3-premedication-on-post-endodontic-pain-100567711","NCT06671743","Premedication on Post-endodontic Pain","Effect of Premedication on Post-endodontic Pain in Patients With Symptomatic Irreversible Pulpitis, a Triple-blinded Randomized Control Trial","Inclusion Criteria:\n\n* Eligibility for root canal treatment Patients diagnosed with symptomatic irreversible pulpitis with normal apical tissue in mandibular molars\n\nExclusion Criteria:\n\n* • Patient under any medication or analgesic intake for pain management.\n\n  * Patients with any systemic health issues\n  * Patient allergies to trypsin-chymotrypsin, ibuprofen, and paracetamol\n  * Pregnancy.\n  * Non-restorable teeth.\n  * Immature roots.\n  * Calcifications.\n  * Resorptions.","50 Years",{"count":370,"type":22},48,[372],"PHASE3","The goal of this clinical trial is to compare the efficacy of preoperative administration of alpha-chemo-trypsin, ibuprofen, and acetaminophen in managing post-endodontic pain in patients with symptomatic irreversible pulpitis. The main question it aims to answer is:\n\nWhat is the efficacy of preoperative administration of alpha-chemo-trypsin, ibuprofen, and acetaminophen in managing post-endodontic pain in patients with symptomatic irreversible pulpitis? Participants will undergo root canal treatment after premedication. Researchers will compare \\[alpha-chemo-trypsin, ibuprofen, and acetaminophen\\] to see the intensity of post-endodontic pain.",[375],"Premedication","2024-11-01",{"date":378,"type":37},"2024-11-04",{"date":380,"type":37},"2024-09-01",{"date":382,"type":22},"2026-11-01",{"name":43,"class":44},{"id":385,"slug":386,"hasResults":11,"nctId":387,"briefTitle":388,"officialTitle":389,"acronym":4,"eligibilityCriteria":390,"healthyVolunteers":11,"sex":17,"minAge":270,"maxAge":391,"enrollmentInfo":392,"targetDuration":4,"studyType":23,"phases":393,"briefSummary":394,"conditions":395,"keywords":397,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":403,"lastUpdatePostDateStruct":404,"startDateStruct":406,"completionDateStruct":408,"leadSponsor":410,"locationsCount":45},"100563359","immersive-vs-non-immersive-virtual-reality-in-enhancing-upper-limb-functions-among-individuals-with-subacute-stage-hemiplegia-100563359","NCT06615141","Immersive v\u002Fs Non-immersive Virtual Reality in Enhancing Upper Limb Functions Among Individuals With Subacute Stage Hemiplegia","Immersive Versus Non-immersive Virtual Reality in Enhancing Upper Limb Functions Among Individuals With Subacute Stage Hemiplegia - A Randomized Controlled Trial","Inclusion Criteria:\n\n* Individuals aged 28-55 years.\n* Diagnosed with hemiplegia due to stroke.\n* ≤ Grade 2 on Modified Ashworth scale.\n* ≤ Stage 2 on Brunnstrom stages of motor recovery.\n* Score of ≥ 35\u002F36 on Cognitive assessment scale for stroke patients (CASP)\n\nExclusion Criteria:\n\n* Contraindications for VR therapy, such as severe motion sickness or photosensitive epilepsy, impaired spatial awareness.\n* Pre-existing neurological conditions such as spinal cord injury, Multiple sclerosis and so affecting upper limb function.","55 Years",{"count":54,"type":22},[25],"The goal of this randomized controlled trial is to compare the effectiveness of immersive virtual reality combined with conventional therapy to the effectiveness of non-immersive virtual reality combined with conventional therapy in enhancing upper limb function in subacute hemiplegic stroke patients.",[396],"Hemiplegia and\u002For Hemiparesis Following Stroke",[398,399,400,401,402],"virtual reality","hemiplegic stroke","Oculus Quest 3","Motor function","Upper limb","2024-09-25",{"date":405,"type":37},"2024-09-26",{"date":407,"type":37},"2024-03-05",{"date":409,"type":22},"2025-01-05",{"name":43,"class":44},""]