[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Hôpital Fribourgeois\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":206},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,7,0,[8,52,73,102,128,149,182],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":40,"lastUpdatePostDateStruct":41,"startDateStruct":44,"completionDateStruct":46,"leadSponsor":48,"locationsCount":51},"100613250","assessing-and-improving-misuse-of-inhalers-in-copd-outpatients-100613250",false,"NCT07264140","Assessing and Improving Misuse of Inhalers in COPD Outpatients","Assessing and Improving Misuse of Inhalers in Outpatients With COPD - The AIMO COPD Study","AIMO COPD","Inclusion Criteria:\n\n1. Age ≥18 years\n2. COPD confirmed by spirometry (FEV1\u002FFVC \\\u003C0.7)\n3. Current use of at least one maintenance inhaler\n4. Follow-up at the outpatient pneumology clinic of HFR Fribourg\n5. Ability to provide written informed consent\n\nExclusion Criteria:\n\n1. Inability to provide informed consent (e.g. severe cognitive impairment, advanced psychiatric disorder, unresolved language barrier)\n2. Life expectancy \\\u003C12 months\n3. Predominant other chronic lung disease (e.g. asthma, fibrosis)\n4. Any condition preventing completion of study procedures\n5. Ongoing participation in another interventional trial on inhaler technique","ALL","18 Years",{"count":20,"type":21},116,"ESTIMATED","INTERVENTIONAL",[24],"NA","Chronic obstructive pulmonary disease (COPD) is a common long-term lung disease that causes breathlessness, cough, and frequent flare-ups. Most patients with COPD use inhaled medications every day. However, many people do not use their inhalers correctly, or they cannot generate the right inspiratory flow for their device. When inhalers are used incorrectly, the medication does not reach the lungs properly, symptoms worsen, and the risk of exacerbations increases.\n\nThis pragmatic randomized controlled trial evaluates whether a structured physiotherapist-led inhaler optimization program improves inhaler use in routine outpatient COPD care. The program is delivered by trained physiotherapists over 12 months and includes three in-person sessions. During these sessions, the physiotherapist evaluates the patient's inhaler technique using placebo devices, measures the patient's peak inspiratory flow with the In-Check DIAL® device, and provides individualized \"teach-to-goal\" education to help patients use their inhalers correctly. If the patient continues to make critical errors or cannot generate the appropriate inspiratory flow for their inhaler, the physiotherapist may recommend adapting the type of inhaler to better match the patient's abilities.\n\nParticipants will be randomly assigned to one of two groups. The intervention group will receive the structured program in addition to their usual COPD care. The control group will continue with usual outpatient care without the physiotherapist-led sessions. All participants will complete baseline and 12-month assessments, which include inhaler technique evaluation, inspiratory flow measurement, respiratory questionnaires, and lung function tests. Telephone follow-up calls will be performed at months 2, 5, and 8 to monitor symptoms, inhaler use, and adherence.\n\nThe main outcome of the study is the proportion of inhalers used incorrectly at 12 months. Incorrect use is defined as at least one critical inhaler technique error or an inspiratory flow that is too low or too high for the patient's device. Secondary outcomes include changes in respiratory symptoms, health status, adherence to inhaled treatment, patient satisfaction with inhalers, confidence in inhaler use, and the number of COPD exacerbations or hospitalizations during the study.\n\nThis research may help improve everyday inhaler use in people with COPD and support more personalized inhaler selection in routine clinical care. Although participants may not benefit directly, the study poses minimal risks and may contribute to future improvements in COPD management.",[27],"Chronic Obstructive Pulmonary Disease (COPD)",[29,30,31,32,33,34,35,36,37,38],"COPD","Chronic Obstructive Pulmonary Disease","Inhaler Technique","Inhaler Misuse","Peak Inspiratory Flow","Inhaler Education","Inhaler Optimization","Respiratory Physiotherapy","In-Check DIAL","Outpatient COPD Care","NOT_YET_RECRUITING","2026-05-11",{"date":42,"type":43},"2026-05-14","ACTUAL",{"date":45,"type":21},"2026-06-01",{"date":47,"type":21},"2029-12-31",{"name":49,"class":50},"Hôpital Fribourgeois","OTHER",1,{"id":53,"slug":54,"hasResults":11,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":4,"eligibilityCriteria":58,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":59,"targetDuration":4,"studyType":22,"phases":61,"briefSummary":62,"conditions":63,"keywords":4,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":4},"100629642","is-6-weeks-immobilization-for-a-chopart-injury-still-state-of-the-art-comparison-between-cast-immobilization-versus-functional-treatment-100629642","NCT07477327","Is 6 Weeks Immobilization for a Chopart Injury Still State of the Art? Comparison Between Cast Immobilization Versus Functional Treatment","Chopart Injury, Randomized Trial","Inclusion Criteria:\n\n* Patients aged above 18 years\n* Patient with a pure ligament Chopart injury or bony avulsion of the ligaments of the Chopart joint line\n* Patient expected to complete length of study\n\nExclusion Criteria:\n\n* Patient which does not understand the informed consent (due to language capacity or mental capacity)\n\n  * Patient non ambulating before time of injury\n  * Patient treated for the fracture outside of Hopital Cantonal Fribourg (the study side)\n  * Patient treated for a fracture at the same foot\u002F ankle before",{"count":60,"type":21},70,[24],"Treatment Arms for Randomization\n\n1. Restrictive treatment: Immobilization in a cast or VACOped boot (lower leg boot with ankle immobilzation) for 6 weeks.\n\n   * Advantage: Provides stable conditions for fracture healing.\n   * Disadvantage: Risk of muscle atrophy and ankle joint stiffness due to prolonged immobilization.\n2. Functional treatment: Weightbearing as tolerated using a rigid-sole shoe.\n\n   * Advantage: Allows early mobilization, reduces muscle atrophy, and helps maintain ankle mobility.\n   * Disadvantage: Potential concern regarding pain, insufficient fracture stabilization, or pseudarthrosis Study Objectives This research project focuses on the treatment of Chopart fractures. In recent years, the number of diagnosed fractures following ankle sprains has increased. This rise is likely due to improved awareness of these injuries and the more frequent use of advanced imaging techniques such as CT scans (Computed Tomography). However, the optimal treatment strategy for these fractures remains unclear.\n\nCurrent treatment approaches range from operative management to conservative treatment with 6-8 weeks of immobilization, and more recently to functional treatment protocols. Most of the available evidence consists of case series, representing a low level of evidence. High-quality comparative studies are currently lacking.\n\nAs a public hospital, Hospital Cantonal Fribourg (HFR) manages a large number of regional trauma cases, including Chopart injuries, with an incidence of approximately 50 cases per year. At present, treatment at HFR is predominantly conservative, involving 8 weeks of immobilization in a cast or a VACOped boot. While immobilization allows sufficient time for fracture healing, it may result in muscle atrophy and ankle joint stiffness. Recent literature suggests that a more functional treatment approach may lead to promising results. However, it remains unclear whether earlier weightbearing and functional rehabilitation improve overall outcomes or result in prolonged pain and increases the risk of complications. Therefore, the aim of this study is to compare different non-operative treatment strategies using both patient-reported outcome measures and objective gait analysis.\n\nThe primary objective of this study is to evaluate patient-reported outcomes following different non-operative treatment strategies for Chopart fractures. In addition, the study will assess differences in gait patterns between the two study arms and correlate these findings with patient-reported outcomes and quality of life. The study also aims to determine the timeline required to regain a normal gait pattern after injury.\n\nOutcome Measures The primary outcome will be patient-reported functional outcome and quality of life, assessed using a 22-item questionnaire combining the EFAS Score (European Foot and Ankle Society) and the Short Form-12 health survey. The secondary outcome will be objective gait analysis parameters.",[64],"Foot Ankle Injuries","2026-03-13",{"date":67,"type":43},"2026-03-17",{"date":69,"type":21},"2026-10-01",{"date":71,"type":21},"2030-10-01",{"name":49,"class":50},{"id":74,"slug":75,"hasResults":11,"nctId":76,"briefTitle":77,"officialTitle":78,"acronym":79,"eligibilityCriteria":80,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":81,"targetDuration":4,"studyType":22,"phases":83,"briefSummary":84,"conditions":85,"keywords":89,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":51},"100615463","gastric-ultrasound-versus-gastroscopic-aspiration-100615463","NCT07292935","Gastric Ultrasound Versus Gastroscopic Aspiration","Diagnostic Performance of Preoperative Gastric Ultrasound Compared to Gastroscopic Aspiration: A Prospective Clinical Study","GUSGA","Inclusion Criteria:\n\n* Adults aged ≥ 18 years\n* Indication for gastroscopy (scheduled or urgent), allowing complete aspiration of gastric contents\n* Feasibility of performing gastric ultrasound within one hour prior to the endoscopic procedure\n* Provision of written informed consent\n\nExclusion Criteria:\n\n* Pregnancy\n* History of major gastric or esophageal surgery\n* Known disorders of gastric emptying (e.g., gastroparesis, gastric outlet obstruction)\n* Cognitive impairment or language barriers preventing understanding of the study protocol\n* Active vomiting or technical impossibility to aspirate gastric contents",{"count":82,"type":21},1390,[24],"This is a prospective, single-center observational study conducted at the Fribourg Cantonal Hospital to evaluate the diagnostic performance of preoperative gastric ultrasound in determining gastric content and volume. Upper gastrointestinal endoscopy with complete suction of gastric contents serves as the reference standard.\n\nAdult patients (≥ 18 years) scheduled for elective or urgent gastroscopy are consecutively recruited. A gastric ultrasound is performed within one hour before the endoscopic procedure. The antral cross-sectional area is measured in standardized positions (supine and right lateral decubitus), and gastric volume is estimated using validated formulas. Gastric content is categorized into three grades (empty, low-risk liquid content, or high-risk\u002Fsolid content).\n\nDuring gastroscopy, complete aspiration of gastric contents is performed at the start of the procedure. The aspirated volume and qualitative characteristics (liquid vs. solid) are recorded, and the stomach is classified as empty, partially full, or full by the endoscopist.\n\nThe primary objective is to determine the accuracy of gastric ultrasound in identifying a full stomach. Secondary objectives include evaluating the qualitative agreement between ultrasound and gastroscopy, correlating estimated gastric volume with aspirated volume, and identifying an optimal ultrasound-based volume threshold predictive of a full stomach.\n\nApproximately 1,390 patients will be enrolled over one year to obtain at least 139 \"full stomach\" cases, based on prevalence estimates and sample size calculations. Statistical analyses will include diagnostic performance metrics, Cohen's kappa, correlation tests, Bland-Altman plots, and ROC curve analysis.",[86,87,88],"Aspiration Risk","Full Stomach Status","Gastric Content",[90,91,92,93],"Gastric Ultrasound","Gastroscopy","Estimated Gastric Volume","Preoperative Evaluation","2025-12-18",{"date":96,"type":43},"2025-12-24",{"date":98,"type":21},"2026-02",{"date":100,"type":21},"2027-01-31",{"name":49,"class":50},{"id":103,"slug":104,"hasResults":11,"nctId":105,"briefTitle":106,"officialTitle":107,"acronym":108,"eligibilityCriteria":109,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":110,"targetDuration":4,"studyType":112,"phases":4,"briefSummary":113,"conditions":114,"keywords":4,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":120,"lastUpdatePostDateStruct":121,"startDateStruct":123,"completionDateStruct":125,"leadSponsor":127,"locationsCount":51},"100594074","impact-of-glp-1-receptor-agonists-on-patients-with-ipmn-100594074","NCT07014709","Impact of GLP-1 Receptor Agonists on Patients With IPMN","Impact of GLP-1 Receptor Agonists on Patients With Intraductal Papillary Mucinous Neoplasms: A Retrospective Multicentric Cohort Study","IPMN-GLP1RA","Inclusion Criteria:\n\n* \\> 18 years old\n* Radiological diagnosis of IPMN\n* Treated with GLP-1 RAs.\n* Patients must have provided prior informed consent for the use of their coded clinical data in research.\n\nExclusion Criteria:\n\n* radiological diagnosis of IPMN is unclear,\n* no documented history of GLP-1 RAs use\n* patients did not provide signed informed consent, or have documented refusal for research.",{"count":111,"type":21},30,"OBSERVATIONAL","This study investigates the impact of GLP-1 receptor agonists (GLP-1 RAs) on patients with intraductal papillary mucinous neoplasms (IPMNs), a type of pancreatic cystic neoplasm that can progress to malignancy. With the increasing use of GLP-1 RAs for managing diabetes and obesity, concerns about their potential to influence pancreatic conditions, like IPMNs, have emerged. Although GLP-1 RAs are generally safe, their effects on pre-existing pancreatic conditions remain unclear.\n\nThe study aims to evaluate whether GLP-1 RA use in IPMN patients is linked to changes in pancreatic cyst characteristics, the incidence of acute pancreatitis, variations in tumor markers, and the progression of IPMNs to high-grade dysplasia or malignancy. A retrospective analysis will be conducted using medical data from patients diagnosed with IPMNs and treated with GLP-1 RAs between 2010 and 2024 at three Swiss hospitals. Key outcomes will include radiological changes, the incidence of acute pancreatitis, and potential shifts in IPMN surveillance or need for surgical intervention",[115,116,117,118,119],"IPMN","IPMN, Pancreatic","GLP-1","Intraductal Papillary Mucinous Neoplasm of Pancreas","Glucagon-Like Peptide-1 Receptor Agonists","2025-06-02",{"date":122,"type":43},"2025-06-11",{"date":124,"type":21},"2025-05-31",{"date":126,"type":21},"2026-10-31",{"name":49,"class":50},{"id":129,"slug":130,"hasResults":11,"nctId":131,"briefTitle":132,"officialTitle":133,"acronym":4,"eligibilityCriteria":134,"healthyVolunteers":135,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":136,"targetDuration":4,"studyType":112,"phases":4,"briefSummary":138,"conditions":139,"keywords":4,"overallStatus":142,"whyStopped":4,"lastUpdateSubmitDate":120,"lastUpdatePostDateStruct":143,"startDateStruct":145,"completionDateStruct":147,"leadSponsor":148,"locationsCount":51},"100574690","prophylactic-mesh-reinforcement-after-open-aortic-aneurysm-repair-100574690","NCT06762561","Prophylactic Mesh Reinforcement After Open Aortic Aneurysm Repair","Prophylactic Mesh Reinforcement After Open Aortic Aneurysm Repair: a Retrospective Study","Inclusion Criteria:\n\n* Adult patients (≥18 years old) who underwent open abdominal aortic aneurysm (AAA) repair with prophylactic retromuscular mesh reinforcement between January 2019 and January 2024\n* Availability of complete medical records, including preoperative history, surgical details, and postoperative follow-up data\n* Attendance at a clinical follow-up examination at least one year after the procedure\n* General informed consent signed for the use of medical data for research purposes\n\nExclusion Criteria:\n\n* Patients with incomplete or missing medical records, including preoperative, intraoperative, or follow-up data\n* Patients who required a re-laparotomy involving incision or suture of the prophylactic mesh and subsequently developed an incisional hernia.\n* Patients who did not attend the required clinical follow-up examination at least one year postoperatively.",true,{"count":137,"type":21},20,"The goal of this retrospective observational study is to evaluate whether prophylactic mesh reinforcement during abdominal wall closure can prevent incisional hernias (IH) in patients undergoing open abdominal aortic aneurysm (AAA) repair. The main questions it aims to answer are:\n\n* Does mesh reinforcement reduce the incidence of incisional hernias?\n* What is the frequency of associated postoperative complications? Researchers will compare the outcomes of patients who underwent mesh-reinforced closures to literature-reported outcomes for non-mesh cases to assess differences in IH incidence and complications.\n\nParticipants will:\n\n* Undergo clinical follow-ups and abdominal ultrasounds to detect IH.\n* Complete quality-of-life questionnaires (EQ-5D and PROMIS).",[140,141],"Incisional Hernia","Aortic Aneurysm","RECRUITING",{"date":144,"type":43},"2025-06-03",{"date":146,"type":21},"2025-06-01",{"date":126,"type":21},{"name":49,"class":50},{"id":150,"slug":151,"hasResults":11,"nctId":152,"briefTitle":153,"officialTitle":154,"acronym":155,"eligibilityCriteria":156,"healthyVolunteers":135,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":157,"targetDuration":4,"studyType":112,"phases":4,"briefSummary":159,"conditions":160,"keywords":165,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":174,"lastUpdatePostDateStruct":175,"startDateStruct":177,"completionDateStruct":179,"leadSponsor":181,"locationsCount":51},"100590745","follow-up-of-low-acuity-patients-after-redirection-from-a-swiss-emergency-department-using-an-electronic-triage-application-100590745","NCT06971419","FOllow-up of LOW-acuity Patients After REdirection From a Swiss Emergency Department Using an Electronic TRIage Application","FOllow-Up of LOW-Acuity Patients After REdirection From the Emergency Department at Fribourg Cantonal Hospital in Switzerland Using an Electronic TRIage Application: a Monocentric, Prospective Observational Study","FO-LOW-RETRI","Inclusion Criteria:\n\n* Age ≥18 years old\n* Triage level SETS 3 or SETS 4 (classified as semi-urgent or low-acuity)\n* Identified as eligible for redirection by the Logibec electronic triage system\n* Able to speak and read French or German (for informed consent and follow-up)\n* Provides informed consent: Oral consent at Day 2 and Signed informed consent sent by post after inclusion\n\nExclusion Criteria:\n\n* Inability to provide informed consent (e.g., cognitive impairment, language barrier without translation support)\n* Inability to comply with study procedures, such as: Severe hearing impairment without hearing aids; Acute psychiatric conditions preventing participation; Not available for follow-up phone calls within the next 6 months",{"count":158,"type":21},450,"Emergency department (ED) overcrowding is a growing issue, affecting patient safety, healthcare quality, and hospital efficiency. One strategy to manage low-acuity patients is triage-based redirection, where patients with non-urgent conditions are offered the option to receive care at external medical facilities instead of the ED.\n\nThis monocentric, prospective observational study will be conducted at Fribourg Cantonal Hospital, Switzerland, and evaluates the impact of a new electronic triage and redirection system (Logibec Réorientation). The study compares two triage processes:\n\nCurrent practice - Redirection based on the Swiss Emergency Triage Scale (SETS), limited to low-acuity patients (SETS 4).\n\nNew practice - Redirection using the Logibec software, allowing redirection of both low-acuity (SETS 4) and semi-urgent (SETS 3) patients based on predefined criteria.\n\nThe primary objective is to assess whether the new triage-based redirection reduces the number of ED consultations per patient within 48 hours of their initial visit.\n\nSecondary outcomes include:\n\nNumber of consultations in the ED or other medical facilities within 7 days Rate of hospital admissions within 7 days Patient satisfaction with redirection Evolution of health literacy over 6 months Number of ED visits over 6 months Participants are adult patients (≥18 years old) classified as SETS 3-4 and identified as eligible for redirection by the Logibec software. Data will be collected through phone interviews and questionnaires over a 6-month follow-up period.\n\nThis study aims to improve triage efficiency, patient flow management, and healthcare accessibility, while ensuring patient safety in the redirection process.",[161,162,163,164],"Triage","Low Acuity Patients","Health Literacy Level","Non-urgent Emergencies",[166,167,168,169,170,171,172,173],"Patient Satisfaction","emergency department triage","patient redirection","healthcare system efficiency","Referral and Consultation","electronic decision support tool","patient flow","Emergency overcrowding","2025-05-06",{"date":176,"type":43},"2025-05-14",{"date":178,"type":21},"2025-06-15",{"date":180,"type":21},"2026-06-30",{"name":49,"class":50},{"id":183,"slug":184,"hasResults":11,"nctId":185,"briefTitle":186,"officialTitle":186,"acronym":187,"eligibilityCriteria":188,"healthyVolunteers":135,"sex":189,"minAge":190,"maxAge":18,"enrollmentInfo":191,"targetDuration":4,"studyType":22,"phases":192,"briefSummary":193,"conditions":194,"keywords":4,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":198,"lastUpdatePostDateStruct":199,"startDateStruct":201,"completionDateStruct":203,"leadSponsor":205,"locationsCount":4},"100550768","cardiovascular-and-endocrine-response-to-muscular-training-program-of-young-soccer-players-aged-14-18-years-100550768","NCT06451367","Cardiovascular and Endocrine Response to Muscular Training Program of Young Soccer Players Aged 14-18 Years","YoungSoccer","Inclusion Criteria:\n\n* Engaging in a football training program.\n* No history of injuries in the last 6 months requiring surgical intervention.\n* No intake of anabolic supplements.\n* Age 14-18 years old.\n* Normal BMI (18.5 - 24.9 kg\u002Fm²).\n\nParents and participants must consent to receive all pertinent information discovered during the study, such as potential cardiovascular diseases or hormonal disorders.\n\nParticipants must also consent to the sharing of certain private information with their parents or legal guardians. This includes information regarding cannabis use, as well as the consumption of anabolic steroids and other controlled substances. This additional consent ensures transparency and openness in sharing relevant health-related information with parents or legal guardians, particularly for participants under 18 years of age.\n\nFor participants under the age of 18, parental consent or consent from a legal guardian is mandatory in addition to the participant's consent. This ensures that minors have parental approval to take part in the study.\n\nAll participants, regardless of age, must provide their voluntary consent to participate in the study. For participants under the age of 18, consent from one of their parents or legal guardians is also required in addition to the participant's consent.\n\nExclusion Criteria:\n\n* Engaging in other supplemental individual exercise programs.\n* Being a smoker (\\>1 cigarette\u002Fweek).\n* Using any medication at the time of testing.\n* Having any disease.","MALE","14 Years",{"count":111,"type":21},[24],"This study focuses on understanding the cardiovascular and endocrine responses of young soccer players aged 14 to 18 years to a muscular training program. Adolescence is a critical period for physiological development, and investigating these responses can provide insights crucial for athletic performance and overall health. The benefits include promoting overall health, reducing injury risk, and enhancing scientific knowledge. However, intensive training programs may lead to overtraining and potential negative health outcomes if not carefully monitored. The study aims to assess whether additional neuromuscular development over 12 weeks can enhance players' physical fitness and hormonal changes. By examining these outcomes, the study seeks to inform evidence-based training protocols for optimizing adolescent athletes' health and performance in soccer. The study design involves a prospective single-center randomized cohort to investigate these responses comprehensively.",[195,196,197],"Sport Injury","Hormone Disturbance","Cardiovascular Abnormalities","2024-06-19",{"date":200,"type":43},"2024-06-24",{"date":202,"type":21},"2024-06-28",{"date":204,"type":21},"2024-12-31",{"name":49,"class":50},""]