[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Hôpital le Vinatier\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":625},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,37,0,25,[9,41,69,90,112,134,155,176,197,217,239,268,294,333,361,387,413,433,465,491,512,534,557,578,600],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":40},"100634908","bright-light-therapy-during-inpatient-cocaine-detoxification-100634908",false,"NCT07545798","Bright Light Therapy During Inpatient Cocaine Detoxification","COKELUX","Inclusion Criteria:\n\n* Male or female, 18 years of age or older\n* DSM-5 criteria for cocaine use disorder\n* Positive urine screen for cocaine\n* Hospitalization for supervised cocaine detoxification planned within the four upcoming weeks\n* The patients must be insured or beneficiary of a health insurance plan\n* Signed and dated informed consent document(s) indicating that the subject has been informed of all pertinent aspects of the trial\n\nExclusion Criteria:\n\n* Non-stabilized opioid use disorder or other psychostimulant use disorder (e.g., amphetamine, met-amphetamine, cathinones, methylphenidate…)\n* Non-stabilized psychiatric disorder or somatic disease, which is considered incompatible with inclusion by the investigator\n* Current treatment with methylphenidate, modafinil, solriamfetol, melatonin pitolisant, naltrexone, or bupropion.\n* Contraindication to light therapy: retinopathy, pigmentary retinitis, diabetic retinopathy, macular degeneration, glaucoma, recent (i.e., less than three month) eye surgery. (If there is any doubt about an ophthalmological contraindication, a specialist opinion will be requested)\n* Tutorship\n* Pregnant or breastfeeding women: the performance of a pregnancy test before inclusion for women of childbearing age\n* Persons deprived of their liberty by a judicial or administrative decision\n* Persons participating in other research with an exclusion period still in progress at pre-inclusion","ALL","18 Years",{"count":20,"type":21},256,"ESTIMATED","INTERVENTIONAL",[24],"NA","Cocaine is a major psychostimulant used to induce a state of euphoria, improved self-confidence and resistance to fatigue, with suppression of sleep. The progressive use of cocaine leads to a potentially severe addictive process, with sometimes dramatic social repercussions, a major disruption of major physiological functions, such as sleep or nutrition, and risks of psychiatric, neurological or cardiovascular complications.\n\nToday, cocaine addiction is considered to be a growing societal problem, due to the fact that the use of this drug is becoming commonplace. There is no validated consensus or protocol for the management of cocaine addiction and no validated pharmacological treatment. The main therapeutic strategy for cocaine addiction is to organize a supervised cessation of use (withdrawal), followed by assistance in maintaining cessation. Withdrawal is a sensitive period that frequently takes place in a hospital setting, as withdrawal symptoms can occur, with major disruption of circadian rhythms, night-time awakenings, daytime sleepiness, high irritability, and sometimes depression.\n\nReducing the desynchronization of nychthemeral cycles during cocaine withdrawal could be a simple strategy to improve the addictive prognosis and comfort of patients. Light therapy is a medical device consisting of the emission of white light enriched with blue light by a lamp or glasses with an intensity sufficient to stimulate the melanopsin cells of the retina and mimic daylight. Overall, light therapy improves sleep quality, mood, cognitive abilities, and decreases fatigue through direct activation of non-visual brain structures. Given the links between cocaine withdrawal and altered sleep or rhythms, there is some evidence to suggest that light therapy used during cocaine withdrawal may improve the prognosis of patients with cocaine addiction.",[27],"Cocaine-Related Disorders","RECRUITING","2026-06-10",{"date":31,"type":32},"2026-06-12","ACTUAL",{"date":34,"type":32},"2025-09-12",{"date":36,"type":21},"2029-12-30",{"name":38,"class":39},"Hôpital le Vinatier","OTHER",1,{"id":42,"slug":43,"hasResults":12,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":47,"eligibilityCriteria":48,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":49,"targetDuration":4,"studyType":51,"phases":4,"briefSummary":52,"conditions":53,"keywords":55,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":61,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":68},"100602135","impact-of-cocaine-use-and-withdrawal-on-sleep-100602135","NCT07119567","Impact of Cocaine Use and Withdrawal on Sleep","Longitudinal Exploration of Subjective and Objective Sleep Characteristics in Patients With Cocaine Use Disorder During the Withdrawal Process","CokeSo","Inclusion Criteria:\n\n* Male or female, aged 18 years or older\n* Meeting DSM-5 criteria for cocaine use disorder\n* Positive urine drug screen for cocaine\n* Scheduled for inpatient supervised cocaine detoxification within the next four weeks\n* Covered by a national health insurance plan or social security system\n* Have a valid, personal means of contact (telephone or email address) enabling remote follow-up at 6 months.\n\nExclusion Criteria:\n\n* Current diagnosis of opioid use disorder or other psychostimulant use disorders (e.g., amphetamines, methamphetamines, cathinones, methylphenidate)\n* Unstable psychiatric disorder or somatic illness deemed incompatible with study participation by the investigator\n* Current treatment with methylphenidate, modafinil, solriamfetol, melatonin, pitolisant, naltrexone, or bupropion\n* Patients under legal guardianship\n* Pregnant or breastfeeding women: a pregnancy test will be performed prior to inclusion for women of childbearing potential\n* Individuals deprived of liberty by judicial or administrative decision",{"count":50,"type":21},32,"OBSERVATIONAL","This study investigates how cocaine use and withdrawal affect sleep and circadian rhythms in individuals undergoing inpatient detoxification. Using wearable sleep monitors, actigraphy, questionnaires, and hormonal biomarkers, it aims to capture both objective and subjective changes in sleep across three key stages: active use, early withdrawal, and late withdrawal. The study is unique in its ability to explore sleep microstructure, the circadian system's role via melatonin and cortisol measurements, and the dynamic relationship between subjective sleep perception and objective sleep data. It also examines whether sleep quality may serve as a predictive marker of long-term withdrawal success.",[54],"Cocaine Use Disorder",[56,57,58,59,60],"Cocaine use disorder","Withdrawal","Sleep","Polysomnography","Actimetry",{"date":62,"type":32},"2026-06-11",{"date":64,"type":32},"2026-03-19",{"date":66,"type":21},"2028-12-31",{"name":38,"class":39},3,{"id":70,"slug":71,"hasResults":12,"nctId":72,"briefTitle":73,"officialTitle":74,"acronym":75,"eligibilityCriteria":76,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":77,"targetDuration":4,"studyType":22,"phases":79,"briefSummary":80,"conditions":81,"keywords":83,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":85,"startDateStruct":86,"completionDateStruct":87,"leadSponsor":89,"locationsCount":40},"100582716","tdcs-for-catatonic-depression-in-down-syndrome-a-pilot-study-100582716","NCT06866925","tDCS for Catatonic Depression in Down Syndrome: A Pilot Study","Transcranial Direct Current Stimulation as a Treatment for Depression With Catatonic Features in Patients With Down Syndrome: a Pilot Randomized Sham-controlled Study","TOTORO","Inclusion Criteria:\n\n* Patient with Down syndrome\n* Age \\> 18\n* Diagnosis of Major Depressive Disorder MDD with catatonic symptoms according to the DSM-5 criteria\n* Informed consent signed by the patient, by the patient under curatorship, or by the legal representative in the case of a patient under guardianship.\n* Person affiliated to the French social security system or equivalent\n\nExclusion Criteria:\n\n* Pregnancy (checked with a pregnancy test)\n* Contraindication for tDCS(i.e., cochlear implant)\n* Refusal of the patients or their legal representatives\n* Other persons protected under the CSP (judicial safeguard, family habilitation)",{"count":78,"type":21},62,[24],"This study evaluates the efficacy of transcranial direct current stimulation (tDCS) for depression with catatonia in individuals with Down syndrome (DS). 62 patients will be randomized to receive 15 sessions of active or sham tDCS. The primary objective is to measure changes in depressive\u002Fcatatonic symptoms using the Bush-Francis Catatonia Rating Scale (BFCRS). Secondary objectives include safety, cognitive effects, EEG correlates, and biological markers (cortisol, BDNF, cytokines). The study aims to provide a non-pharmacological therapeutic alternative for this population",[82],"Down Syndrome",[84],"catatonia",{"date":62,"type":32},{"date":34,"type":32},{"date":88,"type":21},"2027-09-30",{"name":38,"class":39},{"id":91,"slug":92,"hasResults":12,"nctId":93,"briefTitle":94,"officialTitle":95,"acronym":96,"eligibilityCriteria":97,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":98,"enrollmentInfo":99,"targetDuration":4,"studyType":22,"phases":101,"briefSummary":102,"conditions":103,"keywords":105,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":107,"startDateStruct":108,"completionDateStruct":110,"leadSponsor":111,"locationsCount":40},"100582945","homelessness-and-prevalence-of-neurodevelopmental-disorders-100582945","NCT06869915","Homelessness and Prevalence of Neurodevelopmental Disorders","Prevalence of Neurodevelopmental Disorders in a Homeless Population - Pilot Study","PRECA'TND","Inclusion Criteria:\n\n* Homeless people sheltered in accommodation and social rehabilitation centers\n* Over 18 years of age\n* Who speak French\n* who have given then written informed consent\n\nExclusion Criteria:\n\n\\- Every person who hasn't given their written informed consent.","90 Years",{"count":100,"type":21},150,[24],"Introduction \\& Central question: Psychiatric disorders are highly prevalent in the homeless population, however neurodevelopmental disorders are also at risk of leading to homelessness (Churchard et al., 2018; Casey et al., 2020). Research on this topic is poor in France. This research aims to study the prevalence in France of 3 neurodevelopmental disorders (NDDs) in a homeless population (Autism Spectrum Disorder, Attention Deficit Hyperactivity Disorder and Intellectual Developmental Disorder).\n\nMethods \u002F approach: A 2 phase approach will be used including a screening phase and a diagnosis phase. This research is a pilot study that will include 150 homeless people, over 2 years. The assessment involves combining the results from standardised self-report tools, direct observation and informant-report, thus guaranteeing an objective and thorough diagnosis. This approach gives a better picture of actual behaviour but also a better understanding of the person's development.\n\nOUTCOME: This study will give insight on how to better understand the profile of the homeless population in France, and the prevalence of autism in this population. It will also bring valuable knowledge on how autism and other NDDs can impact one's path in life and lead to homelessness. The results can help develop targeted cares and measures for homeless people with NDDs.",[104],"Neurodevelopmental Disorders",[106],"homelessness",{"date":31,"type":32},{"date":109,"type":32},"2026-03-09",{"date":88,"type":21},{"name":38,"class":39},{"id":113,"slug":114,"hasResults":12,"nctId":115,"briefTitle":116,"officialTitle":117,"acronym":118,"eligibilityCriteria":119,"healthyVolunteers":120,"sex":17,"minAge":18,"maxAge":121,"enrollmentInfo":122,"targetDuration":4,"studyType":22,"phases":124,"briefSummary":125,"conditions":126,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":128,"startDateStruct":129,"completionDateStruct":131,"leadSponsor":133,"locationsCount":40},"100537942","interaction-between-early-trauma-and-odor-induced-dopamine-release-100537942","NCT06284382","Interaction Between Early Trauma and Odor-induced Dopamine Release","Consequence of Early Trauma on Odor Hedonics Appreciation and DOpamine Release","T-ODOR","Inclusion Criteria:\n\n* Aged 18 years or older\n* Have been selected based on the Childhood Trauma Questionnaire score\n* Non-smoker\n* Be able to speak and read French\n* Sign a consent form before intervention.\n\nExclusion Criteria:\n\n* A pre-existing condition that affects olfaction including congenital anosmia, upper respiratory tract infection, nasal and\u002For sinus disease,\n* Be on medication, with the exception of oral contraceptives\n* Pregnant or breast-feeding woman (check with urine pregnancy tests);\n* Contraindications to TMS or MRI (implanted medical devices or metallic foreign body in the head);\n* Psychiatric disorders\n* Use of psychotropic drugs\n* Have participated in a study involving the injection of a radiotracer during the year",true,"30 Years",{"count":123,"type":21},30,[24],"This prospective, double-blind, parallel-group controlled trial aims to investigate the consequence of early trauma on dopamine release evoked by positive valence odors.",[127],"Trauma, Psychological",{"date":31,"type":32},{"date":130,"type":32},"2026-04-27",{"date":132,"type":21},"2028-12-01",{"name":38,"class":39},{"id":135,"slug":136,"hasResults":12,"nctId":137,"briefTitle":138,"officialTitle":139,"acronym":140,"eligibilityCriteria":141,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":142,"enrollmentInfo":143,"targetDuration":4,"studyType":22,"phases":145,"briefSummary":146,"conditions":147,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":149,"startDateStruct":150,"completionDateStruct":152,"leadSponsor":154,"locationsCount":40},"100506436","people-bereaved-by-violent-death--negative-event-biases-and-temporal-perception-100506436","NCT05874362","People Bereaved by Violent Death : Negative Event Biases and Temporal Perception","People Bereaved by Violent Death : a Negative Event Biases and Temporal Perception Study","PrEVENT","Inclusion Criteria:\n\n* An age between 18 and 65 years old\n* Recent bereavement by violent death of a relative in first and second degree\n\nExclusion Criteria:\n\n* Protected adults\n* Lack of mastering French language\n* History of neurodegenerative disorder\n* History of psychiatric disorder treated pharmacologically with modification of the basic treatment in the month preceding the death\n* The take of an benzodiazepine treatment in the 24th hours before the first visit (T0)","65 Years",{"count":144,"type":21},61,[24],"A violent death is defined by its brutality, unexpectedness and is secondary to an external cause (suicide, homicide, accident). Bereavement following a violent death constitutes a particular clinical situation, at risk of complications. Research on bereavement after a violent death shows higher risks of psychiatric and somatic complications than in bereavement by non-violent death. These complications, sometimes comorbid, take the form of depressive episodes, post-traumatic stress disorders, suicidal behavior and prolonged grief disorders after 12 months, precociously mediated by ruminations.\n\nProcesses responsible for this increased risk of complications are poorly documented. Current literature relates mainly to socio-demographic and epidemiological factors which, alone, do not explain this difference in risks. Further research is needed exploring other kinds of data and processes. To our knowledge, there is no description of early neurocognitive functioning in people bereaved after violent death. This study aims at exploring early neurocognitive processes which can lead to complications in people bereaved by violent death.",[148],"Post Traumatic Stress Disorder",{"date":31,"type":32},{"date":151,"type":32},"2023-09-19",{"date":153,"type":21},"2026-12-19",{"name":38,"class":39},{"id":156,"slug":157,"hasResults":12,"nctId":158,"briefTitle":159,"officialTitle":160,"acronym":161,"eligibilityCriteria":162,"healthyVolunteers":12,"sex":17,"minAge":163,"maxAge":142,"enrollmentInfo":164,"targetDuration":4,"studyType":22,"phases":166,"briefSummary":167,"conditions":168,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":170,"startDateStruct":171,"completionDateStruct":173,"leadSponsor":175,"locationsCount":40},"100502590","implementation-of-refocus-training-program-in-mental-health-services-100502590","NCT05824234","Implementation of REFOCUS Training Program in Mental Health Services","Multicenter Study on the Implementation of a Training Program in the Orientation of Care Towards Recovery (REFOCUS) in Mental Health Services","RETAFORM","Inclusion Criteria:\n\n* Age from 15 to 65 years old.\n* Diagnosis of schizophrenia, schizoaffective disorder, schizotypal disorder and schizophreniform disorder or bipolar disorder, borderline personality disorder, disabling anxiety or depressive disorder (DSM-V criteria; APA, 2013).\n* Patients cared for by the team or unit benefiting from REFOCUS training\n* French mother tongue.\n* Patient affiliated or entitled to a social security scheme\n* Patient having received information about the study and having confirmed their participation in the study by signing the consent form\n* For minors (\\\u003C 18 years), information given to holders of parental authority and signature of consent.\n* For patients under curatorship, form signed by the patient and information given to the curator\n\nExclusion Criteria:\n\n* Age less than 15 years old\n* Patients under guardianship\n* Presence of an associated intellectual disability\n* Neurological disorders of vascular, infectious or neurodegenerative origin.\n* Taking somatic drugs with a cerebral or psychic impact (eg corticosteroids).","15 Years",{"count":165,"type":21},760,[24],"Training of mental health service teams in the orientation of care towards recovery through a 3-day training course: REFOCUS. This training aims to orient care towards recovery. Following this training, evaluation of the effectiveness of the implementation of REFOCUS training in mental health services.",[169],"Mental Disorders",{"date":31,"type":32},{"date":172,"type":32},"2023-06-19",{"date":174,"type":21},"2027-06-30",{"name":38,"class":39},{"id":177,"slug":178,"hasResults":12,"nctId":179,"briefTitle":180,"officialTitle":181,"acronym":182,"eligibilityCriteria":183,"healthyVolunteers":120,"sex":17,"minAge":18,"maxAge":184,"enrollmentInfo":185,"targetDuration":4,"studyType":22,"phases":187,"briefSummary":188,"conditions":189,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":191,"startDateStruct":192,"completionDateStruct":194,"leadSponsor":196,"locationsCount":40},"100493893","reality-monitoring-and-dopamine-100493893","NCT05711082","REALITY MONITORING AND DOPAMINE","The Role of Dopamine in Reality Memory","MORDOR","Inclusion Criteria:\n\n* Healthy volunteers who have given their written informed consent\n* Men and women from 18 to 45 years old\n* Normal or corrected vision\n* Being fluent in French or French for native language\n* Being affiliated with health insurance\n\nExclusion Criteria:\n\n* Healthy volunteers who have given their written informed consent\n* Men and women from 18 to 45 years old\n* Normal or corrected vision\n* Being fluent in French or French for native language\n* Being affiliated with health insurance\n* Inadmissibility of the subject's consent or refusal\n* Working-memory deficit (as controlled with MMSE score\\\u003C 23)\n* Any past or current psychiatric or somatic condition(as controlled with the Mini International Neuropsychiatric Interview, MINI)\n* Any past or current neurological condition\n* History of cranio-cerebral trauma, arterial hypotension or hypertension, cardiological or serious medical condition\n* Abnormal potassium dosage (below 3.1 mmol\u002FL or above 4.9 mmol\u002FL)\n* Anormal ECG\n* History of schizophrenia or bipolar disorder in first-degree relatives\n* Alcohol-drinking and caffeine intake at least during 24 hours before each session\n* Drug therapy excepting contraceptives\n* Cardiologic or severe medical conditio\n* Pregnancy(checked with a pregnancy autotest), lactation, or insufficient contraceptive measure (precautionary measure)\n* Consumption of recreational drugs during the last 6 months\n* Known sensitivity to any of the study medication and their excipients\n* Lactose intolerance\n* Porphyria\n* Hepatic insufficiency","45 Years",{"count":186,"type":21},39,[24],"Reality-monitoring characterizes the ability to determine whether information was perceived in the environment or only imagined . Impaired reality-monitoring abilities have been associated with hallucinations in patients with schizophrenia and patients with Parkinson's disease.\n\nThe investigators hypothesize a link between dopaminergic (DA) transmission and reality-monitoring.",[190],"Neurosciences",{"date":31,"type":32},{"date":193,"type":32},"2024-01-15",{"date":195,"type":21},"2027-02-28",{"name":38,"class":39},{"id":198,"slug":199,"hasResults":12,"nctId":200,"briefTitle":201,"officialTitle":202,"acronym":203,"eligibilityCriteria":204,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":205,"targetDuration":4,"studyType":22,"phases":207,"briefSummary":208,"conditions":209,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":211,"startDateStruct":212,"completionDateStruct":214,"leadSponsor":216,"locationsCount":40},"100442069","efficiency-assessment-of-breform-a-multicentric-stepped-wedge-randomized-control-trial-100442069","NCT05036590","Efficiency Assessment of BREFORM. A Multicentric Stepped-wedge Randomized Control Trial.","Efficiency Assessment of a Mental Health Professionals' Training Course for a Short Psychoeducational Program (BREF) for Families and Caregivers of Patients With Schizophrenia or First Psychotic Episode.","BREFORM","Inclusion Criteria:\n\n* people over 18yo\n* first-degree relatives (parents, siblings, children) or spouse of the patient\n* primary caregiver of a patient with schizophrenic disorders or first psychotic episode (DSM5)\n* consenting to participate to the study\n\nExclusion Criteria:\n\n* mental disorder on Axis I\n* having already benefited from a family intervention such as psychoeducation\n* caring for several people with severe psychiatric disorders\n* receiving income for the caring activities\n* being legally responsible of the patient\n* having difficulty understanding fluent French\n* illiterate",{"count":206,"type":21},206,[24],"In psychiatry, caregiver burden is associated with excess physical and psychological morbidity in relatives of patients with schizophrenic disorders Single or multi-family psychoeducation for caregivers of patients with schizophrenic disorders or first episode psychosis has a direct benefit on the health of the caregiver and an indirect benefit on the health of the ill family member. It is associated with a reduction in the rate of relapse and re-hospitalization and with better compliance with treatment. For single-family psychoeducation, the number of caregivers to be treated to avoid re-hospitalization of the sick family member is 3. For caregivers, psychoeducation is accompanied by an improvement in knowledge of the disorders and coping strategies. Therefore, international recommendations recommend that psychoeducation for caregivers be systematic, early, and integrated into routine care.\n\nCurrently, the organization of the French care system does not allow these recommendations to be met. In order to increase the use of psychoeducation in France, early interventions for caregivers must be offered systematically. The effectiveness of early psychoeducation for caregivers needs to be evaluated; only three randomized controlled trials are available in the literature and none have been conducted in France.",[210],"Schizophrenia",{"date":31,"type":32},{"date":213,"type":32},"2022-04-05",{"date":215,"type":21},"2026-12-31",{"name":38,"class":39},{"id":218,"slug":219,"hasResults":12,"nctId":220,"briefTitle":221,"officialTitle":222,"acronym":223,"eligibilityCriteria":224,"healthyVolunteers":120,"sex":17,"minAge":18,"maxAge":184,"enrollmentInfo":225,"targetDuration":4,"studyType":22,"phases":227,"briefSummary":228,"conditions":229,"keywords":230,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":232,"lastUpdatePostDateStruct":233,"startDateStruct":234,"completionDateStruct":236,"leadSponsor":238,"locationsCount":40},"100380712","french-source-monitoring-task-100380712","NCT04237155","French Source-monitoring Task","Development of a Source-monitoring Task in French Adapted to Neuroimaging Protocols","SOUMO","Inclusion Criteria:\n\n* Men and Women aged between 18 and 45\n* Having given their written informed consent\n* Native French speakers\n* Normal or corrected-to-normal vision\n* Education level greater than or equal to 8 (in years)\n* For the healthy control group, no history of previous diagnosed psychiatric disorders (according to the criteria of the Diagnostic and Statistical Manual of Mental Disorders - DSM5), absence of first-degree relatives diagnosed with spectrum disorder schizophrenia and bipolar disorder (DSM).\n* For the schizophrenia patients group, meeting the DSM5 criteria for schizophrenia.\n\nExclusion Criteria:\n\n* Do not consent to be included in the study\n* History of hearing impairments\n* People who cannot read\n* Presence of neurological or somatic diseases\n* Being under tutorship or curatorship",{"count":226,"type":21},120,[24],"Source-monitoring is a cognitive process that refers to the ability to remember the source of an information. Source-monitoring processes are usually studied using experimental behavioral tasks. These tasks, which are very heterogeneous, are not all available in French and, for the most part, cannot be used in neuroimaging protocols.\n\nThe aim of this project is to develop an experimental task which allows the measurement of source-monitoring performances, and which is adapted to neuroimaging protocols in a French-speaking population.",[210],[231],"Sorce-monitoring","2026-06-09",{"date":62,"type":32},{"date":235,"type":32},"2020-02-07",{"date":237,"type":21},"2027-02-01",{"name":38,"class":39},{"id":240,"slug":241,"hasResults":12,"nctId":242,"briefTitle":243,"officialTitle":244,"acronym":245,"eligibilityCriteria":246,"healthyVolunteers":120,"sex":17,"minAge":18,"maxAge":142,"enrollmentInfo":247,"targetDuration":4,"studyType":22,"phases":249,"briefSummary":250,"conditions":251,"keywords":254,"overallStatus":259,"whyStopped":4,"lastUpdateSubmitDate":260,"lastUpdatePostDateStruct":261,"startDateStruct":263,"completionDateStruct":265,"leadSponsor":267,"locationsCount":4},"100642923","precision-hd-tacs-for-enhancing-sensory-experience-in-schizophrenia-100642923","NCT07632261","Precision HD-tACS for Enhancing Sensory Experience in Schizophrenia","Precision HD-tACS-Based Therapy for the Qualitative and Phenomenological Enhancement of Sensory Experiences in Schizophrenia","TherACles","Inclusion Criteria for control group and patient:\n\n* Be aged 18 to 65 years inclusive.\n* Have read and understood the study information sheet.\n* Be affiliated with a social security system or be a beneficiary.\n* Have normal or corrected-to-normal vision (glasses or contact lenses).\n\nExclusion Criteria for control group :\n\n* Any contraindication to tACS, e.g., cardiac pacemaker or other devices that could interfere with the electric field.\n* Any contraindication to MRI, e.g., neurological stimulator, pacemaker, cardiac defibrillator, cardiac or vascular prosthesis, intracranial clips or clamps, cerebrospinal fluid shunt, metallic fragments in the eyes, cochlear implants, severe claustrophobia. (A standardized MRI screening questionnaire will be provided.)\n* Pregnancy or breastfeeding. (Pregnancy status will be verified with a test on the day of the exam.)\n* Legal incapacity (under guardianship, conservatorship, or judicial\u002Fadministrative detention) or inability to provide informed consent.\n* Major psychiatric disorders (excluding tobacco use disorder).\n* Neurological disorders.\n* Severe somatic disorders that could interfere with participation.\n* Uncorrected visual impairments.\n* Recent consumption of substances likely to alter brain activity (alcohol, drugs, etc.).\n* Presence of any psychiatric disorder.\n* Under legal protection (guardianship or conservatorship).\n\nExclusion Criteria - Patient Group\n\nA potential patient participant will be excluded if they have:\n\n* Any contraindication to tACS, e.g., cardiac pacemaker or other devices that could interfere with the electric field.\n* Any contraindication to MRI, e.g., neurological stimulator, pacemaker, cardiac defibrillator, cardiac or vascular prosthesis, intracranial clips or clamps, cerebrospinal fluid shunt, metallic fragments in the eyes, cochlear implants, severe claustrophobia. (A standardized MRI screening questionnaire will be provided.)\n* Pregnancy or breastfeeding. (Pregnancy status will be verified with a test on the day of the exam.)\n* Legal incapacity (under guardianship, conservatorship, or judicial\u002Fadministrative detention) or inability to provide informed consent.\n* Major psychiatric disorders other than schizophrenia (excluding tobacco use disorder).\n* Neurological disorders.\n* Severe somatic disorders that could interfere with participation.\n* Uncorrected visual impairments.\n* Recent consumption of substances likely to alter brain activity (alcohol, drugs, etc.).",{"count":248,"type":21},80,[24],"To ensure unified sensory perception, the brain must link information from different senses across time and space. This unification of perception often referred to as a perceptual \"binding constraint\" is a prerequisite for any organized perception. Patients with schizophrenia exhibit deficits in the spatiotemporal binding of sensory information . Electroencephalography (EEG) studies highlight the role of delta-theta oscillatory dynamics (2-8 Hz) in neuronal entrainment processes underlying spatiotemporal binding, which enables the formation of a coherent and organized perceptual representation . These same dynamics are disrupted in schizophrenia .\n\nIn tasks assessing perceptual binding, such alterations manifest as widened temporal binding windows, reflecting impaired temporal structuring of visual events. Physiologically, these disruptions may stem from impaired feedback mechanisms within the cortico-cerebello-thalamo-cortical (CCTC) loop. Schizophrenia patients also exhibit functional and structural deficits in the pulvinar and frontal cortex, key nodes of the CCTC loop .\n\nRecent technical advances in transcranial neurostimulation have reinforced its potential as a therapeutic tool. High-definition transcranial alternating current stimulation (HD-tACS) now enables individualized modulation of pre-identified neural networks , including targeted interventions for schizophrenia . Based on a personalized stimulation protocol, this research project proposes precision HD-tACS therapy, tailored for each patient according to their delta-theta peak frequency measured via EEG and the optimal functional stimulation site identified with functional MRI (fMRI). Stimulation will be applied functionally, i.e., while the patient performs a cognitive task.\n\nStructural connectivity alterations have been observed in fronto-thalamic, thalamo-cingulate, and cortico-cerebellar pathways in schizophrenia, potentially underpinning temporal and spatial binding deficits. Assessing the integrity of the CCTC loop with diffusion tensor imaging (DTI) will allow quantification of fiber coherence and white matter density connecting cortical and subcortical regions within this network.To evaluate both baseline perceptual deficits and the potential improvements induced by stimulation, a control group of healthy participants will be included.",[252,253],"SCHIZOPHRENIA 1 (Disorder)","Sensory Perceptual Characteristics",[255,256,257,258],"perceptual binding","sensory perception","transcranial stimulation","tACS","NOT_YET_RECRUITING","2026-06-05",{"date":262,"type":32},"2026-06-08",{"date":264,"type":21},"2026-06-15",{"date":266,"type":21},"2030-05-01",{"name":38,"class":39},{"id":269,"slug":270,"hasResults":12,"nctId":271,"briefTitle":272,"officialTitle":273,"acronym":274,"eligibilityCriteria":275,"healthyVolunteers":120,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":276,"targetDuration":4,"studyType":22,"phases":278,"briefSummary":279,"conditions":280,"keywords":285,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":260,"lastUpdatePostDateStruct":288,"startDateStruct":289,"completionDateStruct":290,"leadSponsor":292,"locationsCount":293},"100596131","psychoeducation-program-for-family-caregivers-coordinated-by-an-aprn-100596131","NCT07041463","Psychoeducation Program for Family Caregivers Coordinated by an APRN","Impact of a New Psychoeducation Program Coordinated by an Advanced Practce Nurse on the Burden of Family Caregivers of Patients With a First Pyschotic Episode.","APIPEP","Inclusion Criteria:\n\n* Caregiver relative of a patient under the care of the FEP team and meeting the criteria of international recommendations of FEP diagnosis made by the specialized team of less than 6 months, between 18 and 35 years of age.\n* Caregiver having received information about the study and having giveń consent.\n* Caregiver covered by a health insurance plan\n\nExclusion Criteria:\n\n* Caregiver under curatorship, guardianship, safeguard of justice, family habilitation or future protection mandate\n* Caregiver participating in another study that may interact with this one\n* Caregiver not fluent in French (comprehension\u002Freading)\n* Caregiver who has already received psycho-education on FEP\n* Patient's opposition to caregiver's participation in research",{"count":277,"type":21},180,[24],"The aim of this study is to assess the impact of implementing a specific family program coordinated by APRNs, covering the 5 levels of the family care pyramid through a consultation, an individual psychoeducation program and a group psychoeducation program, on improving caregiver burden and thus contributing to the recovery of users suffering from FEP.\n\nDetailed Description: Psychotic disorders are among the most disabling chronic pathologies in psychiatry. These disorders modify the individual's perceptions, thoughts, moods, behaviours and day-to-day functioning (Implementing interventions as early as possible in the first psychotic episode (FEP) would be likely to decrease the severity and consequences of the illness and improve prospects for recovery. Evidence supports the establishment of multidisciplinary teams to detect early and treat early those experiencing FEP and those at increased risk of psychosis. Recommended interventions include cognitive-behavioral therapies, family interventions, employment and educational support, and above all, at the heart of the system, case management. These specialized teams need to be multidisciplinary, bringing together psychiatrists, psychologists and social workers in addition to case managers. More recently in France, Advanced practice nurse (APRN) have joined these teams. But getting young people to accept both disorders and care is a difficult necessity, and remains a major challenge. Poor compliance with treatment is said to be one of the primary causes of relapse after FEP. Factors that increase the risk of relapse include initially more severe symptoms, persistent substance abuse, poor adherence to treatment and inadequate support from family and friends. Nowadays, support from a close caregiver for a person living with a psychic disorder is recognized as a very favorable factor for long-term prognosis. But the occurrence of a FEP often has the effect of a tidal wave for loved ones, who present high levels of psychological distress and feelings of burden. Unfortunately, it is still difficult for families to gain access to family caregiver support services, which are still insufficiently available and often unknown to them. A number of barriers stand in the way of systematically proposing family interventions, such as health professionals' lack of awareness of the effectiveness of interventions aimed at family carers, their difficulty in establishing a double therapeutic alliance with the young person and his or her family, or the misperception that family interventions are in contradiction with professional secrecy.\n\nThe pyramid of family care in early intervention presents the family support that should be available to families of young people with FEP. The levels of intervention are designed to meet the support needs of family caregivers and can be used flexibly depending on specific needs or the phase of the psychotic episode. Also, APRNs could contribute to the success of these caregiver support programs thanks to their skills in prevention, assessment and coordination of complex pathways. This study therefore aims to determine the extent to which a specific program coordinated by APRNs can influence the burden of a family caregiver of a young person suffering from FEP.",[281,282,283,284],"First Episode Psychosis (FEP)","Caregiver Burden","Nurse Practitioners","IMPACT OF A NEW PSYCHOEDUCATION PROGRAM COORDINATED BY AN ADVANCED PRACTICE NURSE ON THE BURDEN OF FAMILY CAREGIVERS OF PATIENTS WITH A FIRST PSYCHOTIC EPISODE",[281,286,287],"Caregiver burden","Advanced Practice Nurse",{"date":232,"type":32},{"date":260,"type":32},{"date":291,"type":21},"2030-11-04",{"name":38,"class":39},5,{"id":295,"slug":296,"hasResults":12,"nctId":297,"briefTitle":298,"officialTitle":299,"acronym":300,"eligibilityCriteria":301,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":302,"enrollmentInfo":303,"targetDuration":4,"studyType":22,"phases":305,"briefSummary":306,"conditions":307,"keywords":310,"overallStatus":259,"whyStopped":4,"lastUpdateSubmitDate":325,"lastUpdatePostDateStruct":326,"startDateStruct":328,"completionDateStruct":330,"leadSponsor":332,"locationsCount":40},"100637560","using-illusions-to-boost-social-cognition-100637560","NCT07602712","Using Illusions to Boost Social Cognition","Socio-cognitive Benefits of Exposure to Visual Illusions in Patients With Psychotic Disorders","SOLLUSIONS","Inclusion Criteria:\n\n* Aged 18 to 40 years\n* Fluent French speaker\n* Has provided written informed consent\n* For individuals under guardianship (curatorship): inclusion is permitted if the curator is available to assist or advise when needed.\n* Established diagnosis of schizophrenia, schizoaffective disorder, schizophreniform disorder, or brief psychotic disorder according to theDiagnostic and statistical manual of mental disorders (DSM-5-TR) criteria\n* Presence of social cognition impairment, defined by:subjective complaint reported by the participant or identified by care teams regarding difficulties in social interaction and clinical confirmation of observable difficulties (e.g., social withdrawal, misinterpretation of others' intentions, inappropriate social behaviour)\n* Membership or entitlement to a social security plan\n\nExclusion Criteria:\n\n* Clinical state incompatible with participation in group-based activities (e.g., severe psychomotor agitation, severe behavioural disturbance)\n* Concurrent participation in another social cognition remediation program\n* Diagnosis of intellectual disability\n* Insufficient comprehension of French for verbal interaction and test completion\n* Significant change in psychotropic medication within the past month\n* Uncorrectable visual impairment preventing participation\n* Pregnant women\n* Individuals under full guardianship (tutorship)","40 Years",{"count":304,"type":21},60,[24],"This study aims to explore whether the observation of complex visual objects can help improve social cognition in people living with psychotic disorders. Social cognition refers to the ability to understand what others think, feel, or intend, and plays a key role in social relationships and daily interactions.\n\nMain questions this study aims to answer:\n\n* Does dyadic exposure to complex visual objects improve mental state attribution, as measured by the Faux Pas Test?\n* Does the intervention enhance related domains of social cognition, including implicit intention inference (Hinting Task), interpretation of complex interactions (Movie for the Assessment of Social Cognition, MASC), and reduction of hostile attribution biases (Ambiguous Intentions Hostility Questionnaire, AIHQ)?\n* Are improvements maintained after one month, and do patients who receive the intervention later (waitlist group) show the same benefits once exposed?",[308,309],"Schizophrenia Spectrum Disorders","Social Cognition",[210,311,309,312,313,314,315,316,317,318,319,320,321,322,323,324],"Psychosis","Mentalizing","Theory of Mind","Cognitive Remediation","Metacognition","Perspective-Taking","Visual Illusions","Viewpoint Illusions","Bottom-Up Intervention","Sensorimotor Rehabilitation","Faux Pas Test","Hinting Task","Social Interaction","Rehabilitation in Psychosis","2026-05-19",{"date":327,"type":32},"2026-05-22",{"date":329,"type":21},"2026-07",{"date":331,"type":21},"2029-02",{"name":38,"class":39},{"id":334,"slug":335,"hasResults":12,"nctId":336,"briefTitle":337,"officialTitle":338,"acronym":339,"eligibilityCriteria":340,"healthyVolunteers":120,"sex":17,"minAge":18,"maxAge":142,"enrollmentInfo":341,"targetDuration":4,"studyType":22,"phases":343,"briefSummary":344,"conditions":345,"keywords":347,"overallStatus":259,"whyStopped":4,"lastUpdateSubmitDate":352,"lastUpdatePostDateStruct":353,"startDateStruct":355,"completionDateStruct":357,"leadSponsor":359,"locationsCount":360},"100639603","evaluation-of-a-virtual-reality-based-version-of-the-multiple-errands-test-in-alcohol-use-disorder-100639603","NCT07593664","Evaluation of a Virtual Reality-based Version of the Multiple Errands Test in Alcohol Use Disorder","Evaluation of a Virtual Reality-based Version of the Multiple Errands Test for the Assessment of Executive Functions in Alcohol Use Disorder","EVIMETAL","Inclusion Criteria:\n\n* written consent\n* Normal or corrected vision and hearing\n* Membership or entitlement to a social security plan\n* spoken and written French\n* third party liability insurance\n\nfor patients only :\n\n* at least 6 criteria for AUD based on the Diagnostic and statistical manual of mental disorders\n* At the end of withdrawal: treatment with a diazepam equivalent of ≤ 20 mg\u002Fday\n\nExclusion Criteria:\n\n* under tutorship\u002F judicial protection\n* Sensory or motor impairment (impeding the use of virtual reality and\u002For mobility)\n* Severe neurological disorder (such as dementia or Korsakoff's syndrome)\n* Photosensitive epilepsy (contraindication for the use of virtual reality)\n* Any other condition deemed incompatible with the study, at the investigator's discretion\n* Montreal Cognitive Assessment (MoCA) score \\\u003C 10 (severe cognitive impairment)\n* Breastfeeding or pregnant women\n* Familiarity with the supermarket visited during the MET test\n\nFor controls only :\n\n* History of alcohol use disorder\n* score ≥ 8 on the Alcohol Use Disorders Identification Test\n* Score on the Frontal Assessment Battery \\\u003C 16 (or \\\u003C 15 if education is below secondary level)",{"count":342,"type":21},90,[24],"The goal of this study is to validate the virtual version of the Multiple Errands Test (V-MET) as a tool for assessing executive functions in patients with alcohol use disorder (AUD).\n\nMore specifically, the project aims to:\n\n1. evaluate if the performance in the virtual version of the test is related to the performance in the original test in patients with AUD.\n2. establish whether the virtual version of the test is sensitive enough to detect patients with or without an executive function deficit.\n\nAll participants will perform the original version (in a real-life supermarket) and the virtual version of the test (in a virtual reality environment).\n\nPerformance in the two versions of the test will be compared. Participants will also complete a battery of neuropsychological tests and questionnaires.",[346],"Alcohol Use Disorder (AUD)",[348,349,350,351],"Multiple Errands Test","Executive functions","Virtual reality","Alcohol Use Disorder","2026-05-18",{"date":354,"type":32},"2026-05-20",{"date":356,"type":21},"2026-05",{"date":358,"type":21},"2028-06",{"name":38,"class":39},2,{"id":362,"slug":363,"hasResults":12,"nctId":364,"briefTitle":365,"officialTitle":366,"acronym":367,"eligibilityCriteria":368,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":369,"targetDuration":4,"studyType":22,"phases":371,"briefSummary":372,"conditions":373,"keywords":375,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":379,"lastUpdatePostDateStruct":380,"startDateStruct":382,"completionDateStruct":384,"leadSponsor":386,"locationsCount":40},"100602143","feasibility-study-of-a-combined-intervention-for-suicidal-inpatients-in-psychiatric-crisis-units-100602143","NCT07119671","Feasibility Study of a Combined Intervention for Suicidal Inpatients in Psychiatric Crisis Units.","Peer-Aid and Hope Box: A Feasibility Study of a Combined Intervention for Suicidal Patients Hospitalized in a Psychiatric Crisis Unit","HOPAIR","Inclusion Criteria:\n\n* Major ;\n* Hospitalized in a psychiatric crisis unit;\n* Having attempted suicide in the month preceding hospitalisation;\n* Able to give free and informed consent;\n* Having given consent;\n* French-speaking person with at least B1 level (reading and writing);\n* With access to the technical resources required for the study;\n* With a postal address.\n\nExclusion Criteria:\n\n* Presenting a relational modality incompatible with the proposed intervention (agitation, acute delirium, major cognitive disorders or psychic disorganisation, etc.);\n* Included in another research protocol related to suicide prevention.",{"count":370,"type":21},42,[24],"Since 2014, suicide prevention has been a national priority and is one of the 3 priority areas of the mental health plan's roadmap .\n\nHospitalization offers a crucial opportunity for life-preserving intervention . Brief health interventions and contacts are reputed to be easy to implement, effective and inexpensive .\n\nThe Hope Box is a practical emotional management tool that aims to encourage the expression of reasons for living by materializing them in a customizable box, filled with objects, photos, writings and memories in order to find comfort and hope .\n\nPeer support use their experiential knowledge of disorders and recovery to accompany people and help humanize care . They can play a decisive role in suicide prevention .\n\nIn contrast to an approach focusing only on risk factors, peer support and the Hope Box are both focus on protective factors, the strengths of the people concerned and hope.\n\nThe primary objective of this study is to evaluate the feasibility of the HOPAIR intervention (peer-support and Hope Box, completed by a reminder postcard) with suicidal people hospitalized in psychiatric crisis units. Its secondary objective is to assess the potential effectiveness on intensity of hopelessness, sense of self-efficacy, reasons for living, perceived social support and suicidal recurrence at 3 months.\n\nThis is a mixed-methods study involving 40 patients and 2 peer support in two crisis hospitalization units.",[374],"Suicide Prevention",[376,377,378],"Suicide prevention","Hope box","Pair aid","2026-04-16",{"date":381,"type":32},"2026-04-21",{"date":383,"type":32},"2025-09-24",{"date":385,"type":21},"2029-10-15",{"name":38,"class":39},{"id":388,"slug":389,"hasResults":12,"nctId":390,"briefTitle":391,"officialTitle":392,"acronym":393,"eligibilityCriteria":394,"healthyVolunteers":120,"sex":17,"minAge":18,"maxAge":395,"enrollmentInfo":396,"targetDuration":4,"studyType":22,"phases":397,"briefSummary":398,"conditions":399,"keywords":401,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":405,"lastUpdatePostDateStruct":406,"startDateStruct":408,"completionDateStruct":410,"leadSponsor":412,"locationsCount":40},"100616258","emotional-processes-in-adults-with-intellectual-developmental-disorder-100616258","NCT07303270","Emotional Processes in Adults With Intellectual Developmental Disorder","Assessing Emotional Processes in Adults With Intellectual Developmental Disorder Using the ACQUISS Battery","EmoTDI","Inclusion Criteria:\n\nIDD group :\n\n* Diagnosis of IDD according to DSM-V criteria\n* aged between 18 and 3 years\n* French speaking\n* Membership or entitlement to a social security plan\n* informed consent, or that of the tutor, to take part in the study\n* presence of a caregiver to complete the questionnaires at V2.\n\nControl group :\n\n* aged between 18 and 35 years\n* French speaking\n* Membership or entitlement to a social security plan\n* Informed written consent to take part in the study.\n\nExclusion Criteria:\n\nIDD group :\n\n* visual or auditory impairments, evaluated at V1\n* non stabilized epilepsy\n* undergoing treatments that can impact brain or psychological functioning\n* major motor disorders\n* breastfeeding or pregnant woman\n\nControl group :\n\n* neurodevelopmental or psychiatric disorder\n* history of brain trauma (TBI, stroke, etc…) or non-stabilized epilepsy\n* visual or auditory impairments, evaluated at V1\n* non stabilized epilepsy\n* undergoing treatments that can impact brain or psychological functioning\n* major motor disorders\n* breastfeeding or pregnant woman","35 Years",{"count":304,"type":21},[24],"Emotions play a crucial part in the quality of life, interpersonal relationships and mental health in general. In adults presenting with intellectual developmental disorder (IDD), emotional abilities may be hindered, thus leading to more challenging behaviors. A better understanding of emotional processes of adults with IDD may help improve the efficiency of behavioral interventions and better improve their quality of life.\n\nThe primary goal of this study is to better characterize the abilities and weaknesses of adults with IDD concerning their emotional processes, in comparison to a healthy population. The secondary goals are :\n\n* to determine if these difficulties are underlined by oculomotor and attention (auditory and visual) processes\n* to determine if behavioral difficulties, as reported by the families of adults with IDD, are underlined by specific difficulties in facial emotion recognition, emotion identification in context and\u002For identification of vocal emotions.",[400],"Intellectual Developmental Disorder",[400,402,403,404],"emotional processing","Cognitive assessments","Social cognition","2026-03-31",{"date":407,"type":32},"2026-04-01",{"date":409,"type":32},"2026-02-19",{"date":411,"type":21},"2028-11-20",{"name":38,"class":39},{"id":414,"slug":415,"hasResults":12,"nctId":416,"briefTitle":417,"officialTitle":417,"acronym":418,"eligibilityCriteria":419,"healthyVolunteers":120,"sex":17,"minAge":18,"maxAge":302,"enrollmentInfo":420,"targetDuration":4,"studyType":22,"phases":421,"briefSummary":422,"conditions":423,"keywords":4,"overallStatus":259,"whyStopped":4,"lastUpdateSubmitDate":425,"lastUpdatePostDateStruct":426,"startDateStruct":428,"completionDateStruct":430,"leadSponsor":432,"locationsCount":40},"100625866","characterization-of-the-neural-bases-of-mental-imagery-in-individuals-with-borderline-personality-disorder-an-eeg-study-100625866","NCT07428200","Characterization of the Neural Bases of Mental Imagery in Individuals With Borderline Personality Disorder: An EEG Study","BABO","Inclusion Criteria:\n\n* For patients, a diagnosis of borderline personality disorder (established by a board-certified psychiatrist during a structured interview using the MINI) based on the Diagnostic and Statistical Manual of Mental Disorders (DSM-5)\n* For healthy individuals, no psychiatric disorders according to the DSM-5 (except for tobacco use)\n* Must be between 18 and 40 years old\n* Must provide a signed, free, and informed consent form\n* To be affiliated with a social security scheme in France or to be a beneficiary of such a scheme\n\nExclusion Criteria:\n\n* Known neurological disorders (patient group and control participants)\n* Comorbid psychiatric disorders (e.g., current depressive episode; ADHD treated with methylphenidate; bipolar disorder)\n* Active substance use disorder (excluding tobacco)\n* Pregnancy or breastfeeding\n* Guardianship\n* Consuming more than three alcoholic drinks in the past 24 hours\n* Consuming alcohol on the day of the experiment\n* Consuming tea or coffee less than one hour before the experiment",{"count":78,"type":21},[24],"Borderline Personality Disorder (BPD) involves altered social cognition, notably dysfunctional processing of cues signaling potential social exclusion and heightened social pain. This study uses EEG during a controlled Cyberball task to test whether BPD patients show a functionally altered social-pain network, particularly increased theta activity, when experiencing induced social exclusion.",[424],"Borderline Personality Disorder BPD","2026-02-17",{"date":427,"type":32},"2026-02-23",{"date":429,"type":21},"2026-03-01",{"date":431,"type":21},"2029-03-01",{"name":38,"class":39},{"id":434,"slug":435,"hasResults":12,"nctId":436,"briefTitle":437,"officialTitle":438,"acronym":439,"eligibilityCriteria":440,"healthyVolunteers":120,"sex":17,"minAge":441,"maxAge":442,"enrollmentInfo":443,"targetDuration":4,"studyType":22,"phases":445,"briefSummary":446,"conditions":447,"keywords":449,"overallStatus":259,"whyStopped":4,"lastUpdateSubmitDate":457,"lastUpdatePostDateStruct":458,"startDateStruct":460,"completionDateStruct":462,"leadSponsor":464,"locationsCount":360},"100622530","duration-of-moment-in-autism-100622530","NCT07384819","Duration of Moment in Autism","Evaluation of Visual Perception Development in Autism: Duration of a Moment","DOMA","Inclusion Criteria:\n\n* Children aged 3 or 5 years\n* Either with a diagnosis of Autism Spectrum Disorder (ASD) or typically developing (neurotypical)\n* No intellectual disability (per Mullen, Denver, or psychometric report)\n* Normal or corrected vision and hearing\n* Written informed consent from legal guardians\n* Legal guardians affiliated to a French social security plan\n* For ASD group only : classification as prototypical or non-prototypical based on clinical evaluation\n\nExclusion Criteria:\n\n* Neurological disorder\n* Parental or child refusal to participate\n* For neurotypical children: developmental delay or psychiatric diagnosis","36 Months","71 Months",{"count":444,"type":21},228,[24],"This study investigates the temporal dynamics of perception and attention in children with Autism Spectrum Disorder (ASD), focusing on two key phenomena: the Temporal Integration Window (TIW) and the attentional blink. Using eye-tracking, 3- and 5-year-old children with ASD (prototypical or not) will be compared to age-matched neurotypical peers.\n\nThe investigators hypothesize that children with ASD exhibit shorter TIWs and attentional blinks, reflecting faster perceptual sampling and attentional processing. These characteristics may contribute to sensory hypersensitivity and difficulties in complex, unpredictable environments such as social situations. The protocol includes two experimental tasks.",[448],"Autism Spectrum Disorder",[450,451,452,453,454,455,456],"autism","Prototypical autism","Temporal Integration Window","Attentional Blink","Eye-tracking","Visual perception","Infant development","2026-02-03",{"date":459,"type":32},"2026-02-05",{"date":461,"type":21},"2026-02-16",{"date":463,"type":21},"2028-08-16",{"name":38,"class":39},{"id":466,"slug":467,"hasResults":12,"nctId":468,"briefTitle":469,"officialTitle":469,"acronym":470,"eligibilityCriteria":471,"healthyVolunteers":120,"sex":17,"minAge":18,"maxAge":184,"enrollmentInfo":472,"targetDuration":4,"studyType":51,"phases":4,"briefSummary":473,"conditions":474,"keywords":477,"overallStatus":259,"whyStopped":4,"lastUpdateSubmitDate":483,"lastUpdatePostDateStruct":484,"startDateStruct":486,"completionDateStruct":488,"leadSponsor":490,"locationsCount":40},"100617091","motivation-learning-and-decision-making-in-changing-environments-100617091","NCT07314112","Motivation, Learning and Decision Making in Changing Environments","MOTILEARN","Inclusion Criteria:\n\n* Age between 18 and 45\n* Fluent in French (reading and speaking)\n* Membership or entitlement to a social security plan\n* Have given written, informed consent to take part in the study\n* Normal or corrected-to-normal vision\n* Right-handed\n* Body mass index (BMI) between 18.5 and 30\n\nNon-inclusion Criteria:\n\n* contraindication to MRI: pacemaker, heart battery, cardiac defibrillator, certain heart valves or neurosurgical clips, cochlear implant, implanted automated injection systems (insulin pump), intraocular metal projectiles, people who work or have worked with metals (excluding X-rays prior to MRI).\n* under guardianship or curatorship or deprived of their liberty\n* Participating in a clinical trial or in a period of exclusion from a previous clinical trial\n* Breast-feeding or pregnant women\n* claustrophobia\n* Neurological disorder or severe chronic illness (diabetes, heart, kidney, lung or liver disease, inflammatory disease, psychiatric illness, etc.).\n* The participant does not wish to be informed of any abnormalities detected during the MRI examination.",{"count":226,"type":21},"The main objective of this study is to develop a models of sequential decision-making, learning and motivation that includes emotions as driving forces of adaptive behaviour. Using functional magnetic resonance imaging (fMRI), the investigators will test the hypotheses that distinct parts of the prefrontal cortex play specific roles in naturalistic decision-making.\n\nThe main hypothesis is that distinct regions of the prefrontal cortex will be differentially involved in learning, motivation, and decision-making in naturalistic tasks. More specifically, the investigators hypothesise that by using a novel set of tasks they have designed in combination with fMRI, they can construct a neurocognitive model that explains how humans make adaptive decisions in dynamic and temporally extended reward environments.\n\nA key region that the investigators believe will play a role in representing the internal and external parameters necessary for adaptive behaviours in the tasks is the anterior cingulate cortex. Depending on the task requirements, this region will further interact with other distinct prefrontal regions such as the frontal pole or dorsolateral prefrontal cortex.\n\nSecondary hypotheses will also be investigated, specific to each specific task.\n\nAll data will be collected during a single visit lasting approximately 3.5 hours for each participant. Participants will perform a cognitive task inside the MRI scanner. Each participant will perform only one of the three possible cognitive conditions\u002Ftasks (Treasure Hunt, Fastest Queue, or Farm Game).\n\nEach task is presented in the form of a video game played on a computer. Participants play a character who makes repeated choices. Participants are asked to try to collect as many points as possible within a limited time frame (Farm Game) or with limited trials (Fastest Queue and Treasure Hunt).",[475,476],"Neurocognitive Model","Decision-Making",[478,479,480,481,482],"Cognitive neurosciences","decision making","reward","cognitive psychology","fMRI","2026-01-05",{"date":485,"type":32},"2026-01-07",{"date":487,"type":21},"2026-01",{"date":489,"type":21},"2029-01",{"name":38,"class":39},{"id":492,"slug":493,"hasResults":12,"nctId":494,"briefTitle":495,"officialTitle":496,"acronym":497,"eligibilityCriteria":498,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":184,"enrollmentInfo":499,"targetDuration":4,"studyType":22,"phases":501,"briefSummary":502,"conditions":503,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":505,"lastUpdatePostDateStruct":506,"startDateStruct":508,"completionDateStruct":510,"leadSponsor":511,"locationsCount":40},"100364450","a-computer-based-cognitive-remediation-program-for-adults-with-intellectual-disability-100364450","NCT04025398","A Computer-based Cognitive Remediation Program for Adults With Intellectual Disability","REHABILITUS: a New Cognitive Remediation Tool for Adults With Intellectual Deficiency With Behavioral Disorders","REHABILITUS","Inclusion Criteria:\n\n* Adults aged 18 to 45 inclusive;\n* Behavioral disorders corresponding to a total score on the ABC scale \\> 15\n* Presence of a family caregiver (parent, friend) or professional (reeducator, professional of the medico-social sector) stakeholder of the project;\n* Diagnosis of mild to moderate intellectual disability (assessed by WAIS-IV battery and VABS-II less than 3 years ago;\n* French or secondary mother tongue;\n* Psychoactive treatment unchanged during the month prior to inclusion;\n* Adult or legal representative who has given written and informed consent to participate in the study. By default, the adult's oral agreement will be collected (as well as the written consent of the legal representative);\n* Affiliation to the social security scheme or beneficiary of such a scheme.\n\nExclusion Criteria:\n\n* Neurological disorders of vascular, infectious or neurodegenerative origin;\n* Taking medications for general medical purposes with a neurological or psychiatric impact (eg corticosteroids);\n* Simultaneous participation in any other cognitive remediation program targeting attentional, visuospatial and social cognition;\n* Refusal of participation of the person and\u002For his\u002Fher legal representative;\n* Not family or professional caregiver;\n* Presence of Autistic Spectrum Disorders (evaluated by ADOS and ADI if necessary according to the assessment of the investigator)",{"count":500,"type":21},116,[24],"Adults with intellectual disabilities have great difficulty in adapting to social situations and relationships. Cognitive impairment associated with intellectual disability are important factors to understand their difficulties in processing social information. In the field of recognition of facial emotions in particular, basic cognitive processes such as visuospatial and attentional functions, are heavily involved. Cognitive remediation is a management tool widely used by practitioners to help patients who experience cognitive difficulties. Currently, no program can meet specific and validated the problems are adults with intellectual disabilities manner in their daily functioning",[504],"Intellectual Disability","2025-07-30",{"date":507,"type":32},"2025-07-31",{"date":509,"type":32},"2020-06-17",{"date":215,"type":21},{"name":38,"class":39},{"id":513,"slug":514,"hasResults":12,"nctId":515,"briefTitle":516,"officialTitle":516,"acronym":4,"eligibilityCriteria":517,"healthyVolunteers":120,"sex":17,"minAge":18,"maxAge":518,"enrollmentInfo":519,"targetDuration":4,"studyType":22,"phases":521,"briefSummary":522,"conditions":523,"keywords":525,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":505,"lastUpdatePostDateStruct":528,"startDateStruct":529,"completionDateStruct":531,"leadSponsor":533,"locationsCount":40},"100353799","source-monitoring-dficit-in-neuropsychiatric-population-100353799","NCT03886584","Source Monitoring Déficit in Neuropsychiatric Population","Inclusion Criteria:\n\n* Subjects who gave their free and informed consent;\n* Men and women;\n* Aged 18 to 80;\n* Having normal or corrected vision;\n* Mastering the French language (read and spoken);\n* All subjects will not have a working memory deficit preventing the test from being passed (MMSE short version):AM patients should have a score of \\\u003CMMSE \\\u003C26; Patients with pre-dementia AD will be diagnosed according to Dubois criteria (Dubois et al., 2016); patients with early FTD will be diagnosed according to Rascovsky's criteria (Rascovsky et al., 2011); Patients with DCL will be diagnosed according to McKeith's criteria (McKeith et al., 2005), TBP patients will be diagnosed using DSM 5 criteria (Arlington VA, 2013).\n\nExclusion Criteria:\n\n* Inadmissibility of the consent or refusal of the subject.\n* Patients under guardianship","80 Years",{"count":520,"type":21},300,[24],"the investigators will measure source-monitoring ability in patients with several neuropsychiatric condition and in healthy controls appaired in age, sex and educational level. Source-monitoring will be measured thanks to internal- and reality-monitoring informatic tasks.The investigators hypothesized patients with fronto-temporal abnormalities would show more marked deficits than patients with only frontal abnormalities.",[524],"Psychiatric Disorder",[526,527],"Bipolar Disorder","Source-monitoring",{"date":507,"type":32},{"date":530,"type":32},"2019-03-08",{"date":532,"type":21},"2026-07-31",{"name":38,"class":39},{"id":535,"slug":536,"hasResults":12,"nctId":537,"briefTitle":538,"officialTitle":539,"acronym":540,"eligibilityCriteria":541,"healthyVolunteers":12,"sex":17,"minAge":542,"maxAge":543,"enrollmentInfo":544,"targetDuration":546,"studyType":51,"phases":4,"briefSummary":547,"conditions":548,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":550,"lastUpdatePostDateStruct":551,"startDateStruct":552,"completionDateStruct":554,"leadSponsor":556,"locationsCount":40},"100486084","trajectories-and-reactions-of-users-and-relatives-consulting-french-youth-addiction-services-100486084","NCT05609474","Trajectories and Reactions of Users and Relatives Consulting French Youth Addiction Services","Trajectories and Reactions of Users and Relatives Consulting French Youth Addiction Services (Consultations Jeunes Consommateurs)","TRYAD","Inclusion Criteria:\n\nFor users :\n\n* First consultation in CJC\n* From 12 to 25 years old\n\nFor caregivers :\n\n* First consultation in CJC (with or without the youth) or second consultation if accompanying a user\n* ≥ 18 ans\n\nExclusion Criteria:\n\n* inability to reach by phone\n* Insufficient french level","12 Years","25 Years",{"count":545,"type":21},1430,"1 Year","In France, the \"Consultations Jeunes Consommateurs\" (CJC) are the services specialized in the reception of young people for addiction problems. There are more than 500 CJCs throughout France. Depending on the situation, the CJC develops an early intervention strategy aimed either at reducing the risk of developing an addiction or at accelerating entry into appropriate care. The CJCs also meet with family members or professionals who may also independently request help or advice.\n\nSet up by the State since 2004, the action of the CJCs has never been formally evaluated. Only descriptive studies, carried out by the French Observatory of Drugs and Drug Addiction (OFDT), have made it possible to better understand the profile of people who consult CJCs. However, no longitudinal study has yet been carried out to understand the factors associated with the overall evolution of users consulting CJCs, nor with the level of satisfaction of users and those around them. Such objectives are complex, due to the diversity of situations encountered in CJCs and the heterogeneity of the CJCs themselves.",[549],"Addiction","2025-07-29",{"date":505,"type":32},{"date":553,"type":32},"2023-02-15",{"date":555,"type":21},"2028-10-01",{"name":38,"class":39},{"id":558,"slug":559,"hasResults":12,"nctId":560,"briefTitle":561,"officialTitle":562,"acronym":563,"eligibilityCriteria":564,"healthyVolunteers":120,"sex":17,"minAge":565,"maxAge":566,"enrollmentInfo":567,"targetDuration":4,"studyType":22,"phases":568,"briefSummary":569,"conditions":570,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":550,"lastUpdatePostDateStruct":572,"startDateStruct":573,"completionDateStruct":575,"leadSponsor":577,"locationsCount":40},"100411581","understanding-of-psychotic-disorders-in-children-with-22q112ds-100411581","NCT04639388","Understanding of Psychotic Disorders in Children With 22q11.2DS","Characterize the Behavioral Prodromes of Psychotic Disorders in Children With 22q11.2DS Aged From 4 to 13 Years Old","PremiCeS22","Inclusion Criteria:\n\n* Diagnosis of 22q11.2 deletion syndrome or no developmental disease\n* Aged from 4 to 13 years old\n* French language\n\nExclusion Criteria:\n\n* Diagnosis of intellectual deficiency according to DSM 5 criteria\n* Drug prescribed for somatic condition that could influence cerebral functioning","4 Years","13 Years",{"count":248,"type":21},[24],"The study PremiCeS22 will investigate the prodromal signals at the onset of psychotic disorders of children with 22q11.2 deletion syndrome",[571],"22q11.2 Deletion Syndrome",{"date":505,"type":32},{"date":574,"type":32},"2020-11-13",{"date":576,"type":21},"2026-09-30",{"name":38,"class":39},{"id":579,"slug":580,"hasResults":12,"nctId":581,"briefTitle":582,"officialTitle":583,"acronym":584,"eligibilityCriteria":585,"healthyVolunteers":120,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":586,"targetDuration":4,"studyType":22,"phases":588,"briefSummary":589,"conditions":590,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":592,"lastUpdatePostDateStruct":593,"startDateStruct":595,"completionDateStruct":597,"leadSponsor":599,"locationsCount":40},"100526914","motor-imagery-in-aphantasia-100526914","NCT06140940","Motor Imagery in Aphantasia","Probing and Modulating Motor Imagery Capacities in Aphantasia","OLIPHANT","Inclusion Criteria:\n\n* For the aphantasia group only: congenital aphantasia defined as a life-long inability to generate mental imagery (confirmed by a total score of 32 or less on the VVIQ, which is the gold standard questionnaire for aphantasia)\n* For the no-aphantasia group only: typical mental imagery capacities (confirmed by a total score of more than 32 on the VVIQ)\n* Covered by public health insurance\n* Understanding the French language\n* Signed written informed consent after being informed about the study\n\nExclusion Criteria:\n\n* Presence or history of a somatic, neurologic, or mental illness\n* Actual pain or musculoskeletal disorders at the upper limb\n* Having a regular musical activity (more than once a week) because of high manual dexterity\n* Contraindication for noninvasive brain stimulation including the presence of ferromagnetic or magnetic sensitive metal objects implanted in the head or in close proximity (e.g., brain stent, clip, cochlear implants, or stimulator)\n* Pregnancy (controlled by urine pregnancy test in females without reported contraception)\n* Active seizure disorder or history of seizures\n* Participants under curatorship\u002Fguardianship",{"count":587,"type":21},40,[24],"The present study aims to characterize and modulate motor imagery abilities in individuals with aphantasia. The investigators will characterize the neurophysiological and physiological underpinnings of mental imagery abilities in participants with aphantasia by investigating several indices of motor imagery abilities and comparing them to participants with typical mental imagery abilities. The investigators will investigate whether non-invasive brain stimulation applied to the primary motor cortex improves mental imagery abilities in participants with aphantasia.",[591],"Aphasia","2025-07-23",{"date":594,"type":32},"2025-07-24",{"date":596,"type":32},"2024-03-28",{"date":598,"type":21},"2028-01-01",{"name":38,"class":39},{"id":601,"slug":602,"hasResults":12,"nctId":603,"briefTitle":604,"officialTitle":605,"acronym":606,"eligibilityCriteria":607,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":608,"targetDuration":4,"studyType":22,"phases":610,"briefSummary":611,"conditions":612,"keywords":615,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":592,"lastUpdatePostDateStruct":619,"startDateStruct":620,"completionDateStruct":622,"leadSponsor":624,"locationsCount":40},"100514066","metabolomics-during-electroconvulsivotherapy-100514066","NCT05973643","Metabolomics During ElectroConvulsivoTherapy","Study by 1H NMR of the Variations of the Metabolome During the Course of Electroconvulsive Therapy in Patients With Major Depressive Episode","METECT","Inclusion Criteria:\n\n* Major depressive episode according to DSM-5 criteria\n* Diagnosis of major depressive disorder or bipolar disorder\n* MADRS score \\>22\n* having given written, free and informed consent\n* without protective measures\n* resistance criterion defined as failure of 2 antidepressants at an effective dose for a minimum of 6 weeks\n* current major depressive episode according to DSM-5 criteria with indication of treatment by ECT cure\n\nExclusion Criteria - Cannot be included in the study, people:\n\n* whose consent is not admissible or who refuse to participate in the study\n* deprived of liberty by judicial or administrative decision\n* For which there is a particular risk contraindicating the cure of ECT\n* Suffering from schizophrenia spectrum disorders or persistent delusional disorder as described by DSM-5 Criterion D for Major Depressive Disorder\n* suffering from neurological disorders (such as patients suffering from multiple sclerosis, epilepsy, encephalitis, etc.) and\u002For neurodegenerative disorders (such as Parkinson's disease, Alzheimer's disease or related diseases, etc.) as described by criterion C of the major depressive disorder listed in the DSM-5\n* suffering from an acute or chronic systemic inflammatory disease requiring specific treatment with immunomodulators or suppressors. As well as any recurrent inflammatory disease requiring specific management, and which may lead to a differential diagnosis of the characterized depressive episode as described by criterion C listed in the DSM-5",{"count":609,"type":21},50,[24],"Investigators will measure the variation of blood Metabolome through 1H NMR at several time points during the course of electroconvulsivetherapy in patients with a major depressive episode. Patients with a major depressive disorder or a bipolar disorder and a current major depressive episode will be included in this study. Investigators hypothesized that Metabolome could be a source to predict response during ECT and to help understanding underlying biological mechanisms.",[613,614],"Major Depressive Episode","ECT",[616,617,618],"1HNMR","Electroconvulsive Therapy","Major Depression",{"date":594,"type":32},{"date":621,"type":32},"2024-03-11",{"date":623,"type":21},"2026-10-15",{"name":38,"class":39},""]