[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"HEIDEGGER CP\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":76},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,47],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100619347","trial-on-the-impact-of-indirect-calorimetry-guided-nutritional-support-on-patient-centered-outcomes-in-critically-ill-patients---the-optical-study-100619347",false,"NCT07343440","Trial on the Impact of Indirect Calorimetry-Guided Nutritional Support on Patient-Centered Outcomes in Critically Ill Patients - The OPTICal Study","A Randomized Controlled Trial on the Impact of Indirect Calorimetry-Guided Nutritional Support on Patient-Centered Outcomes in Critically Ill Patients - The OPTICal Study","OPTICal","Inclusion Criteria:\n\nAll patients admitted to the ICU with the following criteria:\n\n* ≥18 years old\n* On Mechanical Ventilation\n* Expected ICU length of stay \\>72 hours\n\nExclusion Criteria:\n\n* Refusal of the family or patient\n* Patient transferred from another ICU\n* Pregnant patient\n* Patient is planned for a withdrawal of care or is actively dying\n* Cognitive disorder before ICU\n* Patient is in jail\n* Patients already enrolled in the ongoing NutriPhyT trial","ALL","18 Years",{"count":20,"type":21},356,"ESTIMATED","INTERVENTIONAL",[24],"NA","This multicentric randomized controlled trial aims to evaluate whether indirect calorimetry (IC)-guided nutritional support improves patient-centered outcomes in critically ill adult patients compared to standard formula-based nutritional strategies. The study includes mechanically ventilated patients expected to remain in the ICU for more than 72 hours. The intervention group will receive nutritional targets based on measured resting energy expenditure using the QNRG+ device, with a gradual escalation of energy delivery following current ESPEN guidelines. The primary outcome is quality of life at 3 months post-ICU admission, assessed using the EQ-5D-5L. Secondary outcomes include functional recovery, muscle preservation, infection rates, and rehospitalization. This study is the first to assess the long-term impact of IC-guided nutrition on recovery and quality of life using a patient-centered approach.",[27,28],"Critical Illness","ICU",[30,31,32,33],"Nutrition","Indirect calorimetry","Nutrition therapy","Predictive formula","RECRUITING","2026-05-15",{"date":37,"type":38},"2026-05-19","ACTUAL",{"date":40,"type":38},"2026-01-01",{"date":42,"type":21},"2027-09-01",{"name":44,"class":45},"HEIDEGGER CP","OTHER",3,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":55,"targetDuration":4,"studyType":22,"phases":57,"briefSummary":58,"conditions":59,"keywords":62,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":75},"100505740","optimised-nutritional-therapy-and-early-physiotherapy-in-long-term-icu-patients-nutriphyt-trial-100505740","NCT05865314","Optimised Nutritional Therapy and Early Physiotherapy in Long Term ICU Patients (NutriPhyT Trial)","Optimised Nutritional Therapy and Early Physiotherapy in Long Term ICU Patients: a Randomized Controlled Study (NutriPhyT Trial)","NutriPhyT","Inclusion Criteria:\n\nAny patient admitted to the adult ICU :\n\n* ≥18 years old\n* On mechanical ventilation with an expected length of stay ≥ 7 days\n* Requiring artificial nutrition (enteral and\u002For parenteral nutrition)\n\nExclusion Criteria:\n\nTherapeutic withdrawal Pregnant or breastfeeding patients\n\nNeurological disorders with motor deficits:\n\n* New or pre-existing neuromuscular or nervous system disease\n* Spinal cord injury Severe polytrauma of the lower limbs (amputation etc.) Non-independent ambulation (including walking aids) before ICU admission\n\nFor organizational reasons not allowing follow-up :\n\n* Transfer to another ICU\n* Patient living abroad from Switzerland\n* Patient living in nursing homes preceding to ICU admission\n* Incarcerated patients\n* Intellectual\u002Fcognitive disabilities or language barrier, limiting ability to follow the instructions",{"count":56,"type":21},164,[24],"Due to medical advances and quality of care, mortality in adult intensive care units (ICUs) has decreased significantly in recent years, leading to a significant increase in the number of patients with high rehabilitation needs on discharge from the ICU.\n\nA specific management by a multidisciplinary team has been set up since 2017 at the Geneva-ICU for long-stay patients (hospitalised ≥ 7 days).\n\nThis study aim to assess whether an optimization of the nutritional therapy coupled with an early mobility during and after the ICU stay allows an improvement in the muscle function at hospital discharge compared to patients receiving the standard care.",[27,60,61],"ICU Acquired Weakness","Malnutrition",[63,64,65,66],"Early nutrition therapy","Early mobilisation","Long stay ICU patient","Physiotherapy","2025-08-07",{"date":69,"type":38},"2025-08-12",{"date":71,"type":38},"2023-05-01",{"date":73,"type":21},"2026-09-01",{"name":44,"class":45},1,""]