[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Hadeer Maher Mostafa Mohamed\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":41},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":5},"100612667","antimicrobial-and-anti-inflammatory-effects-of-simvastatin-as-an-intracanal-medication-100612667",false,"NCT07256561","Antimicrobial and Anti-inflammatory Effects of Simvastatin as an Intracanal Medication","Antimicrobial and Anti-inflammatory Effects of Simvastatin as an Intracanal Medication in Endodontically Retreated Teeth With Periapical Radiolucency, Randomized Controlled Clinical Trial","Inclusion Criteria:\n\n* Patients had anon contributory medical history.\n* Patients of age categories between 20 to 40 years old, with no physical disability or psychological problems.\n* Single rooted teeth with type I root canal anatomy.\n* Symptomatic cases of failed endodontic treatment with radiographic evidence of periapical bone loss, and the lesion size ranging from 2mm up to 8mm.\n\nExclusion Criteria:\n\n* Patients with known sensitivity to the pharmaceutical used in this trial\n* Patients with former endodontic mishaps (as ledges, transportations, perforations or separated instruments)\n* Non restorable teeth\n* Presence of an associated sinus tract.\n* Advanced periodontal involvement\n* Teeth representing root fracture.\n* Pregnant women","ALL","20 Years","40 Years",{"count":20,"type":21},54,"ESTIMATED","INTERVENTIONAL",[24],"NA","Successful endodontic treatment and a predictable outcome can only be achieved by effective root canal debridement, irrigation, and elimination of microorganisms .\n\nThe outcome of endodontic treatment performed in controlled clinical environment has demonstrated success rate around 90%.\n\nIn certain cases, endodontic treatment may fail, one of the most common reasons is inability to eliminate microorganisms from the root canal. When non-surgical root canal therapy fails, the treatment options include orthograde re-treatment, periradicular surgery, or extraction.\n\nSimvastatin (SIM) is a drug used primarily to treat hyperlipidemia and protect against cardiovascular diseases. It has been shown to possess pleiotropic effects such as antimicrobial, anti-inflammatory, immunomodulatory, antioxidant, and bone-forming properties .\n\nThe side chain of this material has a single methyl group. It inhibits hydroxymethyl glutarylcoenzyme reductase that prevents endogenous cholesterol synthesis",[27,28],"Endodontically Retard Teeth","Periapical Radiolucency","RECRUITING","2025-11-20",{"date":32,"type":33},"2025-12-01","ACTUAL",{"date":35,"type":33},"2025-08-10",{"date":37,"type":21},"2026-08-10",{"name":39,"class":40},"Hadeer Maher Mostafa Mohamed","OTHER_GOV",""]