[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Hama University\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":106},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,42,63,86],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100539319","evaluating-the-effect-of-injectable-platelet-rich-fibrin-on-accelerating-orthodontic-tooth-movement-100539319",false,"NCT06302296","Evaluating the Effect of Injectable Platelet-rich Fibrin on Accelerating Orthodontic Tooth Movement","Evaluating the Effect of Injectable Platelet-rich Fibrin on Accelerating Orthodontic Tooth Movement During Leveling and Alignment Stage Study Description","Inclusion Criteria:\n\n* The patient's age (18-26). Severe or very severe irregularity of the upper incisors greater than (7 mm) according to Little's index, so it is recommended to extract the upper first premolar.\n\n  * Class I or Class II malocclusion, first model according to Angle, with skeletal class I or II and a normal or mild vertical growth pattern.\n  * All permanent upper teeth, up to the first molar, are present, with the possibility of attaching brackets to all teeth in a correct position.\n  * The patient has good oral health.\n\nExclusion Criteria:\n\n* • The presence of any systemic disease that affects orthodontic dental movement.\n\n  * Severe malalignment of one of the teeth (palatal quadrant, ectopic canine, ectopic premolar).\n  * The patient has undergone previous orthodontic treatment.\n  * The patient is subject to any drug treatment that may affect orthodontic dental movement (cortisone, non-steroidal anti-inflammatory drugs).\n  * The patient has poor oral health.\n  * Commitment to periodic follow-up appointments.","ALL","18 Years","26 Years",{"count":20,"type":21},14,"ESTIMATED","INTERVENTIONAL",[24],"NA","One of the main goals of orthodontic treatment is the reduction of treatment time through faster tooth movement. The previous studies evaluating platelet-rich fibrin (PRF) and orthodontic tooth movement (OTM) are limited, which makes the results difficult to generalize.",[27,28],"Tooth Mobility","Injectable Platelet-rich Fibrin","RECRUITING","2025-09-09",{"date":32,"type":33},"2025-09-15","ACTUAL",{"date":35,"type":21},"2025-12-20",{"date":37,"type":21},"2026-07-15",{"name":39,"class":40},"Hama University","OTHER",1,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":4,"eligibilityCriteria":48,"healthyVolunteers":11,"sex":16,"minAge":49,"maxAge":50,"enrollmentInfo":51,"targetDuration":4,"studyType":22,"phases":53,"briefSummary":54,"conditions":55,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":57,"startDateStruct":58,"completionDateStruct":60,"leadSponsor":62,"locationsCount":41},"100512294","treatment-of-skeletal-class-ii-malocclusion-with-modified-twin-block-appliance-with-clear-plates-100512294","NCT05950581","Treatment of Skeletal Class II Malocclusion With Modified Twin-Block Appliance With Clear Plates","Treatment Skeletal Class II Malocclusion With Modified Twin-Block Appliance With Clear Plates VS Traditional Twin Block","Inclusion Criteria:\n\n* \\- Patients with mixed dentition at age 10.5-13 years.\n* The patient has Skeletal class II malocclusion caused by mandibular retraction ANB \\> 5, 8 mm \\>O.J\\> 5 mm, SNB\\\u003C78, angle (NSAr) ≥ ° 125 and normal placement of the upper jaw.\n* The patient is willing to accept treatment with a removable device.\n* No previous orthodontic treatment\n* the growth model is within the normal or horizontal maxillary opening angle of 30 \\>MM or angle of 400 \\> Björk\n* patients do not have an upper alveolar dental protrusion.\n\nExclusion Criteria:\n\n* -Patients with periodontal disease.\n* patients with a neuromuscular disorder.\n* patients of class I or III of malocclusion.\n* Patients with temporomandibular joint disorder.\n* Patients with Skeletal open bite.\n* Patients with poor oral and gingival health\n* the presence of a unilateral or bilateral posterior crossbite.\n* patients who have upper jaw stenosis and need to be prepared by expansion before functional treatment.\n* any patient who does not meet one or more of the Inclusion criteria will be removed from the study.","10 Years","13 Years",{"count":52,"type":21},32,[24],"Patients with skeletal class II malocclusion who have a retracted lower jaw will be treated in this study. The efficacy of clear Plates in the treatment of Skeletal Class II Malocclusion will be assessed. The skeletal, dental and soft tissues changes resulted by this intervention will be studied and compared with the results of Traditional treatment with fixed appliances.",[56],"Malocclusion, Angle Class II",{"date":32,"type":33},{"date":59,"type":21},"2026-03-15",{"date":61,"type":21},"2026-09-15",{"name":39,"class":40},{"id":64,"slug":65,"hasResults":11,"nctId":66,"briefTitle":67,"officialTitle":68,"acronym":69,"eligibilityCriteria":70,"healthyVolunteers":11,"sex":16,"minAge":71,"maxAge":72,"enrollmentInfo":73,"targetDuration":4,"studyType":22,"phases":75,"briefSummary":76,"conditions":77,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":80,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":41},"100491851","treatment-of-mild-class-ii-malocclusion-in-adult-patients-with-clear-aligners-versus-fixed-multibracket-therapy-100491851","NCT05684510","Treatment of Mild Class II Malocclusion in Adult Patients With Clear Aligners Versus Fixed Multibracket Therapy","Evaluation of Efficacy of Clear Aligners in Correction of Class II Malocclusion Using Intermaxillary Elastics: A Randomized Controlled","malocclusion","Inclusion Criteria:\n\n* \\- Patients with permanent occlusion at age 15-20 years.\n* Patients with class II division I (half cusp or Less) with moderate overjet (2-4mm).\n* Patients with normal or horizontal growth pattern.\n* Mild crowding (\\_\\\u003C2 mm) in maxillary and mandibular arch.\n* Patient with satisfactory periodontal health and good oral hygiene\n* No previous orthodontic treatment\n* Comprehensive medical and dental history ruling out any systemic disease.\n\nExclusion Criteria:\n\n* Patients with periodontal disease.\n* Patients with vertical growth pattern.\n* Patients with missing or extracted teeth except third molar.\n* Patients with temporomandibular joint disorder.\n* Patients with Skeletal open bite.\n* Patients with poor oral and gingival health\n* Patients with neuromuscular disorder.\n* Patients with severe skeletal class II.","15 Years","20 Years",{"count":74,"type":21},24,[24],"Patient with class ii division 1 malocclusion who have mild increased overjet will be treated in this study. The efficacy of clear aligners in the treatment of Class II division 1 Malocclusion Using Intermaxillary Elastics will be assessed. The skeletal, dental and soft tissues changes resulted by this intervention will be studied and compared with the results of Traditional treatment with fixed appliances.\n\nThere are two group:\n\n1. a group of patients in which participants will be undergo to the clear aligners with class ii elastics.\n2. a group of patients in which participants will be undergo to the traditional fixed appliances with class ii elastics.",[78,79],"Malocclusion","Class II Malocclusion",{"date":32,"type":33},{"date":82,"type":21},"2026-08-25",{"date":84,"type":21},"2026-12-01",{"name":39,"class":40},{"id":87,"slug":88,"hasResults":11,"nctId":89,"briefTitle":90,"officialTitle":91,"acronym":4,"eligibilityCriteria":92,"healthyVolunteers":93,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":94,"targetDuration":4,"studyType":22,"phases":96,"briefSummary":97,"conditions":98,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":100,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":41},"100477116","evaluating-the-efficacy-of-micro-osteoperforations-technique-on-the-orthodontic-tooth-movement-acceleration-in-moderate-mandibular-anterior-crowding-cases-treated-with-clear-aligners-100477116","NCT05492773","Evaluating the Efficacy of Micro-Osteoperforations Technique on the Orthodontic Tooth Movement Acceleration in Moderate Mandibular Anterior Crowding Cases Treated With Clear Aligners","Evaluating the Efficacy of Micro-Osteoperforations Technique on the Orthodontic Tooth Movement Acceleration of Dental Crowding Cases Treated With Clear Aligners: A Randomized Controlled Clinical Trial","Inclusion Criteria:\n\n* Completion of permanent dentition (except third molars)\n* Moderate crowding (4-6 mm according to Little's index)\n* Absence of medications intake that interferes with pain perception for at least one week before the beginning of the treatment\n* Number of aligners ≥ 8 aligners.\n\nExclusion Criteria:\n\n* • Systematic diseases that could affect bone and tooth movement and no contraindication avoid oral surgery\n\n  * Medical conditions that affect tooth movement (Corticosteroid, NSAIDs)\n  * Patients had previous orthodontic treatments\n  * Poor oral hygiene or concurrent periodontal disease",true,{"count":95,"type":21},30,[24],"Patients with moderate mandibular anterior crowding will be treated in this study. The efficacy of micro-osteoperforations technique by special drill in accelerating orthodontic tooth movement during clear aligners therapy will be assessed along with patient's pain and satisfaction.\n\nThere are two groups:\n\n1. a group of patients in which participants will be received treatment with the traditional clear aligners technique in addition to a micro-osteoperforations technique.\n2. a group of patients in which participants will be received treatment with the traditional clear aligners technique alone",[99],"Crowding of Anterior Mandibular Teeth",{"date":32,"type":33},{"date":102,"type":21},"2026-06-10",{"date":104,"type":21},"2026-12-04",{"name":39,"class":40},""]