[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Hanoi Medical University\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":366},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,12,0,[8,52,83,113,145,172,199,225,252,280,307,333],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":30,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":40,"lastUpdatePostDateStruct":41,"startDateStruct":44,"completionDateStruct":46,"leadSponsor":48,"locationsCount":51},"100632479","project-yes-for-young-msm-living-with-hiv-in-vietnam-100632479",false,"NCT07514221","Project Yes+ for Young MSM Living With HIV in Vietnam","Adaptation of Project Yes+ to Improve Mental Health and Reduce HIV-related Stigma Among Adolescent and Young Men Who Have Sex With Men Living With HIV in Vietnam","To-Hieu","Inclusion Criteria:\n\n* 16-24 years old Vietnamese;\n* assigned male sex at birth and identifying as male;\n* anal intercourse with another man in the last 12 months;\n* HIV positive status and currently receiving ART at the study sites;\n* currently living in Hanoi and not moving in the next 12 months;\n* at least a score of 5 on either the Patient Health Questionnaire (PHQ-9) or Generalized Anxiety Disorder - 7 (GAD-7)\n\nExclusion Criteria:\n\n* Being currently enrolled in another HIV intervention;\n* Severe psychotic disorders or other interfering problems that require specialty care","MALE","16 Years","24 Years",{"count":21,"type":22},80,"ESTIMATED","INTERVENTIONAL",[25],"NA","In Vietnam, adolescent and young men who have sex with men (AYMSM) are among those most affected by HIV, and they also experience significant HIV-related mental health and stigma challenges. The study team proposes to adapt Project YES+ to address both mental health and internalized HIV stigma among AYMSM living with HIV in Vietnam. This research will build local capacity and develop networks for collaborative research on mental health and stigma in this population between Vietnam, Zambia and the United States.",[28,29],"Mental Disorder","HIV Stigma",[31,32,33,34,35,36,37,38],"MSM","youth","Project Yes","Self-Help+","Project Yes+","internalized stigma","mental disorders","Vietnam","NOT_YET_RECRUITING","2026-06-05",{"date":42,"type":43},"2026-06-09","ACTUAL",{"date":45,"type":22},"2026-06-01",{"date":47,"type":22},"2028-02-28",{"name":49,"class":50},"Hanoi Medical University","OTHER",1,{"id":53,"slug":54,"hasResults":11,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":4,"eligibilityCriteria":58,"healthyVolunteers":11,"sex":59,"minAge":60,"maxAge":4,"enrollmentInfo":61,"targetDuration":4,"studyType":23,"phases":63,"briefSummary":64,"conditions":65,"keywords":69,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":51},"100635670","remote-app-based-rehabilitation-after-rotator-cuff-repair-100635670","NCT07555704","Remote App-based Rehabilitation After Rotator Cuff Repair","Effectiveness of a Combined Intervention Incorporating a Remote Rehabilitation Application for Patients After Arthroscopic Repair of Rotator Cuff Tears: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Demographics: Individuals aged 18 years or older.\n* Diagnosis: Confirmed symptomatic rotator cuff tear requiring surgical intervention, specifically involving:\n\n  * Clinical Presentation: Persistent shoulder pain and functional deficits (e.g., positive impingement signs or weakness in abduction\u002Fexternal rotation) consistent with rotator cuff pathology.\n  * Radiological Confirmation: Imaging evidence (MRI or high-resolution ultrasound) of a full-thickness supraspinatus and\u002For infraspinatus tendon tear.\n  * Tear Characteristics: Small-to-medium-sized tears (maximum diameter \\\u003C 5 cm) categorized as reparable by the attending surgeon.\n* Surgical Procedure: Patients undergoing primary arthroscopic rotator cuff repair (ARCR) utilizing a standardized double-row suture bridge technique.\n* Rehabilitation Adherence: Commitment to follow the standardized postoperative rehabilitation protocol as prescribed by the study.\n* Cognitive and Functional Capacity:\n\n  * Absence of cognitive impairment, with the ability to comprehend and execute complex exercise instructions.\n  * Proficiency in digital literacy, including the regular use of an internet-enabled electronic device (smartphone, tablet, or computer) capable of video-based communication and data transmission.\n* Documentation and Consent:\n\n  * Availability of comprehensive medical records, including pre- and postoperative clinical and radiological data.\n  * Provision of written informed consent by the patient or a legal representative prior to enrollment\n\nExclusion Criteria:\n\n* Pre-existing or concomitant upper extremity dysfunction unrelated to the rotator cuff tear, including cervical disc herniation, cerebrovascular accident (stroke), traumatic brain injury, cervical spinal cord injury, rheumatoid arthritis with shoulder involvement, or brachial plexus injury.\n* Complex or irreparable rotator cuff tears, defined as large or massive tears (\\> 5 cm), high-grade fatty infiltration of the rotator cuff muscles (Goutallier grade ≥ 3), or inability to achieve secure tendon repair using sutures during arthroscopic surgery.\n* Postoperative complications that significantly interfere with rehabilitation, such as surgical site infection, nerve injury with paralysis, or severe deltoid muscle damage.\n* Severe comorbidities that may substantially affect the rehabilitation process or patient safety, including acute coronary syndrome, recent stroke, uncontrolled diabetes mellitus, or other debilitating systemic diseases.\n* Inability or unwillingness to comply with the study protocol, including failure to attend scheduled follow-up assessments or voluntary withdrawal from the study.","ALL","18 Years",{"count":62,"type":22},102,[25],"The aim of this study was to evaluate the effectiveness of a mobile application for telemedicine in patients recovering from arthroscopic rotator cuff tendon repair. Participants were randomly assigned to one of two groups: a test group using a mobile application for exercise guidance and monitoring, or a control group receiving standard paper-based exercise instructions. The study aimed to compare the effectiveness of rehabilitation, treatment adherence, cost savings, and patient satisfaction between the two methods over a 6-month follow-up period.",[66,67,68],"Rotator Cuff Tear","Telemedecine","Rotator Cuff Injuries",[70,68,71,72,73,74],"Rotator Cuff Tears","Telerehabilitation","Mobile Application","Digital Health","Arthroscopic Rotator Cuff Repair","2026-04-21",{"date":77,"type":43},"2026-04-29",{"date":79,"type":22},"2026-04-14",{"date":81,"type":22},"2027-12-31",{"name":49,"class":50},{"id":84,"slug":85,"hasResults":11,"nctId":86,"briefTitle":87,"officialTitle":87,"acronym":4,"eligibilityCriteria":88,"healthyVolunteers":11,"sex":89,"minAge":90,"maxAge":91,"enrollmentInfo":92,"targetDuration":4,"studyType":23,"phases":94,"briefSummary":95,"conditions":96,"keywords":100,"overallStatus":104,"whyStopped":4,"lastUpdateSubmitDate":105,"lastUpdatePostDateStruct":106,"startDateStruct":108,"completionDateStruct":110,"leadSponsor":112,"locationsCount":51},"100624427","ivf-outcomes-with-time-lapse-culture-comparison-between-ppos-and-gnrh-antagonist-protocols-100624427","NCT07409493","IVF Outcomes With Time-Lapse Culture: Comparison Between PPOS and GnRH Antagonist Protocols","Inclusion Criteria:\n\n* Women aged 20-45 years\n* Indicated for in vitro fertilization (IVF) treatment\n* Planned freeze-all embryo strategy\n* Voluntary participation in research.\n\nExclusion Criteria:\n\n* Systemic diseases\n* Use of hormonal medications within 3 months prior to enrollment\n* Oocyte donation cycles\n* Unwilling or unable to participate in research","FEMALE","20 Years","45 Years",{"count":93,"type":22},148,[25],"The goal of this clinical trial is to compare two ovarian stimulation protocols used in in vitro fertilization (IVF): the fixed Progestin-Primed Ovarian Stimulation (PPOS) protocol and the GnRH Antagonist protocol. The study will evaluate IVF outcomes and embryo development patterns using time-lapse embryo monitoring technology. The main questions the study aims to answer are:\n\n* Does the fixed - PPOS protocol achieve similar numbers of mature eggs, good-quality embryos, and clinical outcomes compared to the GnRH Antagonist protocol?\n* Are there differences in embryo development patterns (morphokinetics) between the two protocols when monitored by time-lapse imaging?\n* How does embryo quality (KIDScore) compare between the two protocols?\n\nStudy Design:\n\nResearchers will randomly assign 148 women undergoing IVF to two groups:\n\n* PPOS group (n=74): Will receive FSH injections (oral Duphaston 20mg daily) starting from day 2-3 of the menstrual cycle\n* GnRH Antagonist group (n=74): Will receive FSH injections (Orgalutran 0.25mg injections) when follicles reach ≥14mm\n\nParticipants will:\n\n* Undergo controlled ovarian stimulation with their assigned protocol for approximately 10-12 days\n* Have regular ultrasound monitoring and blood tests to track follicle development\n* Undergo egg retrieval procedure when follicles are mature\n* Have all embryos cultured in the EmbryoScope time-lapse incubator with continuous monitoring\n* Have embryos frozen on Day 5\u002F6 for future transfer\n\nStudy Location:\n\nDepartment of Assisted Reproduction and Andrology, Hanoi Obstetrics and Gynecology Hospital\n\nStudy Duration: January 2026 - June 2028",[97,98,99],"Infertility (IVF Patients)","Embryo Morphokinetics","Progestins Primed Ovarian Stimulation",[101,102,103],"IVF","PPOS","Embryo morphokinetics","RECRUITING","2026-02-12",{"date":107,"type":43},"2026-02-13",{"date":109,"type":43},"2026-01-21",{"date":111,"type":22},"2028-10",{"name":49,"class":50},{"id":114,"slug":115,"hasResults":11,"nctId":116,"briefTitle":117,"officialTitle":118,"acronym":119,"eligibilityCriteria":120,"healthyVolunteers":11,"sex":59,"minAge":60,"maxAge":121,"enrollmentInfo":122,"targetDuration":4,"studyType":23,"phases":124,"briefSummary":125,"conditions":126,"keywords":130,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":137,"lastUpdatePostDateStruct":138,"startDateStruct":140,"completionDateStruct":142,"leadSponsor":144,"locationsCount":4},"100621363","repetitive-transcranial-magnetic-stimulation-combined-with-motor-rehabilitation-improves-motor-and-functional-outcomes-after-ischemic-stroke-100621363","NCT07369648","Repetitive Transcranial Magnetic Stimulation Combined With Motor Rehabilitation Improves Motor and Functional Outcomes After Ischemic Stroke","Effects of Repetitive Transcranial Magnetic Stimulation Combined With Motor Rehabilitation on Motor and Functional Outcomes in Patients With Ischemic Stroke: A Randomized Sham-Controlled Trial","rTMS-MOTOR","Inclusion Criteria:\n\n* Aged 18 to 80 years.\n* Diagnosed with a first-ever ischemic stroke, confirmed by neuroimaging.\n* Presence of unilateral hemiparesis attributable to the first-ever ischemic stroke.\n* Time since stroke onset:\n\n  * Acute stage: \\\u003C 1 month after stroke onset\n  * Subacute stage: 1 to 6 months after stroke onset\n  * Chronic stage: \\> 6 months after stroke onset\n* Moderate neurological impairment, defined as a baseline NIHSS score between 5 and 14.\n* Cognitive ability sufficient to understand and follow instructions, indicated by a baseline MMSE score ≥ 20.\n* Medically stable and able to participate in a structured motor rehabilitation program.\n* Provided written informed consent prior to study enrollment.\n* NIHSS and MMSE scores are assessed at baseline only to characterize neurological severity and cognitive status at study entry\n\nExclusion Criteria:\n\n* Motor impairment caused by conditions other than ischemic stroke, such as musculoskeletal disorders, traumatic brain injury, Parkinson's disease, encephalitis, or other neurological conditions.\n* Contraindications to repetitive transcranial magnetic stimulation, including but not limited to intracranial metallic implants, implanted electronic medical devices (e.g., pacemaker), cochlear implants, known bleeding disorders, pregnancy, history of epilepsy or seizure disorders, severe cardiac disease, severe psychiatric or neurological disorders interfering with participation, or active skin conditions at the stimulation site.\n* History of epilepsy or seizure disorders.\n* Recurrent stroke occurring during the intervention period.\n* Refusal to participate, withdrawal of informed consent, or non-adherence to the intervention protocol.","80 Years",{"count":123,"type":22},66,[25],"Ischemic stroke is a leading cause of long-term motor disability, frequently resulting in hemiplegia and limitations in daily activities and quality of life. Motor rehabilitation is a fundamental component of post-stroke care across all stages of recovery; however, functional outcomes may vary, particularly in patients with persistent motor impairment.\n\nRepetitive transcranial magnetic stimulation (rTMS) is a non-invasive brain stimulation technique that has been used as an adjunct to rehabilitation to modulate cortical excitability and potentially support motor recovery.\n\nThe purpose of this study is to evaluate the effects of low-frequency rTMS combined with conventional motor rehabilitation compared with sham rTMS combined with conventional motor rehabilitation in patients with first-ever ischemic stroke during the acute, subacute, and chronic stages. Motor function, balance, functional mobility, activities of daily living, and stroke-specific quality of life will be assessed at baseline, after the intervention, and at 3-month and 6-month follow-up.",[127,128,129],"Ischemic Stroke","Hemiplegia","Motor Function Impairment",[131,132,133,134,135,136],"Repetitive Transcranial Magnetic Stimulation","rTMS","Motor Recovery","Post-Stroke Hemiplegia","Neurorehabilitation","Motor function","2026-02-06",{"date":139,"type":43},"2026-02-10",{"date":141,"type":22},"2026-02",{"date":143,"type":22},"2028-12",{"name":49,"class":50},{"id":146,"slug":147,"hasResults":11,"nctId":148,"briefTitle":149,"officialTitle":150,"acronym":4,"eligibilityCriteria":151,"healthyVolunteers":11,"sex":59,"minAge":60,"maxAge":4,"enrollmentInfo":152,"targetDuration":4,"studyType":23,"phases":154,"briefSummary":155,"conditions":156,"keywords":159,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":165,"lastUpdatePostDateStruct":166,"startDateStruct":168,"completionDateStruct":170,"leadSponsor":171,"locationsCount":51},"100623432","intermittent-erector-spinae-plane-block-via-subcutaneous-port-for-cancer-pain-100623432","NCT07396558","Intermittent Erector Spinae Plane Block Via Subcutaneous Port for Cancer Pain","Efficacy of Intermittent Erector Spinae Plane Block Via Subcutaneous Port for Cancer-Related Pain in Patients With Lung Cancer","Inclusion Criteria\n\n* Adult patients diagnosed with advanced-stage lung cancer who are currently receiving palliative care only.\n* Presence of chronic cancer-related chest pain lasting longer than 1 month, localized to the thoracic region due to chest wall invasion, pleural involvement, or bone metastases.\n* Performance status ≤ 3 according to the Eastern Cooperative Oncology Group (ECOG), allowing placement of a subcutaneous port and maintenance of local anesthetic administration.\n* Inadequate pain control with conventional analgesic therapies or clinical indication for the addition of regional analgesia.\n* Ability to understand the study procedures and provide written informed consent after receiving a full explanation of the intervention.\n\nExclusion Criteria:\n\n* Chest pain with radiation to the upper extremities, neck, or shoulder, suggestive of non-localized thoracic pain.\n* Severe hepatic or renal dysfunction, or severe heart failure (New York Heart Association class III-IV).\n* Local infection at the injection or port placement site, or uncontrolled systemic infection.\n* Severe cachexia or insufficient subcutaneous tissue that does not allow safe coverage of the subcutaneous port.\n* Known allergy to amide-type local anesthetics or other contraindications to regional anesthesia.\n* Severe cognitive impairment, altered consciousness, or inability to cooperate with post-intervention monitoring.\n* Lack of adequate caregiver support for home-based follow-up after discharge or inability to coordinate follow-up with local healthcare facilities.\n* Severe coagulation disorders, defined as:\n\n  * International normalized ratio (INR) \\> 1.5\n  * Activated partial thromboplastin time (aPTT) \\> 40 seconds\n  * Fibrinogen \\\u003C 1.5 g\u002FL\n  * Platelet count \\\u003C 50 × 10⁹\u002FL.",{"count":153,"type":22},180,[25],"Cancer-related pain is a common and challenging problem in patients with lung cancer, often requiring long-term pain management. Conventional pain treatments, including systemic medications, may not provide adequate relief or may cause significant side effects.\n\nThe erector spinae plane (ESP) block is a regional anesthesia technique that can help reduce pain by delivering local anesthetic near the nerves supplying the chest wall. This study aims to evaluate the effectiveness and safety of intermittent ESP block administered through a subcutaneous port for controlling cancer-related pain in patients with lung cancer.\n\nEligible patients with lung cancer and moderate to severe pain will receive intermittent ESP block injections via a subcutaneous port as part of their pain management plan. Pain intensity, analgesic requirements, and potential side effects will be assessed over time.\n\nThe results of this study may help determine whether intermittent ESP block via a subcutaneous port is a useful and feasible option for improving pain control and quality of life in patients with lung cancer.",[157,158],"Cancer Pain","Erector Spinae Plane Block",[158,160,161,162,163,164],"Regional Anesthesia","Cancer-Related Pain","Lung Cancer","Subcutaneous Port","Palliative Care","2026-02-01",{"date":167,"type":43},"2026-02-09",{"date":169,"type":22},"2026-03-01",{"date":81,"type":22},{"name":49,"class":50},{"id":173,"slug":174,"hasResults":11,"nctId":175,"briefTitle":176,"officialTitle":177,"acronym":4,"eligibilityCriteria":178,"healthyVolunteers":11,"sex":59,"minAge":60,"maxAge":4,"enrollmentInfo":179,"targetDuration":181,"studyType":182,"phases":4,"briefSummary":183,"conditions":184,"keywords":187,"overallStatus":104,"whyStopped":4,"lastUpdateSubmitDate":165,"lastUpdatePostDateStruct":192,"startDateStruct":194,"completionDateStruct":196,"leadSponsor":198,"locationsCount":51},"100540823","weaning-ventilator-using-heart-lung-and-diaphragm-ultrasound-100540823","NCT06321848","Weaning Ventilator Using Heart, Lung And Diaphragm Ultrasound","The Predictive Value Of Heart, Lung And Diaphragm Ultrasound For Ventilator Weaning Outcome Of Surgical Intensive Care Patients","Inclusion Criteria:\n\n* Age \\>= 18\n* The duration of postoperative mechanical ventilation \\>= 48 hours\n\nExclusion Criteria:\n\n* Patient had a diagnosis of progressive neuromuscular diseases\n* Patient had a history of cardiovascular or respiratory disease who depend on a ventilator at home (COPD, severe bronchial asthma)\n* Patients had thoracic surgery or mitral valve surgery.",{"count":180,"type":22},190,"30 Days","OBSERVATIONAL","Postextubation distress is detrimental to the prognosis of critically ill patients with successful spontaneous breathing trial. Failure to wean is known to be connected with heart, lung, and diaphragm problems. The aim of this study was to investigate how a composite model comprising diaphragm, lung, and heart ultrasonography indications could predict the weaning outcome.\n\nMethods: Ultrasonic features of the diaphragm, heart, and lungs are going to be collected along with clinical data about the patients. Either the successful weaning group or the failed weaning group is going to comprised the patients. Multivariate logistic regression analysis is going to be used to identify the variables that may be associated with the likelihood of weaning failure. A multiindicator combination model is going to be developed to increase the predictive accuracy after the possible indicators' accuracy in foretelling the weaning outcome was assessed.",[185,186],"Ventilator Weaning","Ultrasound",[188,189,190,191],"echocardiography","lung ultrasound","diaphragm ultrasound","ventilator weaning",{"date":193,"type":43},"2026-02-03",{"date":195,"type":43},"2024-04-22",{"date":197,"type":22},"2026-04",{"name":49,"class":50},{"id":200,"slug":201,"hasResults":11,"nctId":202,"briefTitle":203,"officialTitle":204,"acronym":4,"eligibilityCriteria":205,"healthyVolunteers":11,"sex":59,"minAge":60,"maxAge":206,"enrollmentInfo":207,"targetDuration":4,"studyType":23,"phases":209,"briefSummary":210,"conditions":211,"keywords":214,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":219,"lastUpdatePostDateStruct":220,"startDateStruct":222,"completionDateStruct":223,"leadSponsor":224,"locationsCount":51},"100621504","ctg-versus-collagen-matrix-for-peri-implant-soft-tissue-augmentation-100621504","NCT07371481","CTG Versus Collagen Matrix for Peri-Implant Soft Tissue Augmentation","Results of Soft Tissue Grafting Around Implant in the Mandible Molar Area","Inclusion Criteria:\n\nAdults aged 18 to 65 years.\n\nPatients requiring dental implant treatment in the mandibular molar region.\n\nPresence of insufficient peri-implant soft tissue thickness (\\\u003C 2 mm).\n\nAdequate general health to undergo minor oral surgery.\n\nAbility and willingness to provide written informed consent and comply with study procedures.\n\nExclusion Criteria:\n\nSystemic conditions or medications that may impair wound healing.\n\nHeavy smoking (more than 10 cigarettes per day).\n\nHistory of allergy or hypersensitivity to collagen-based materials.\n\nPrevious graft failure or complications at the intended implant site.\n\nLoss of three or more adjacent teeth in the study area (excluding third molars).","65 Years",{"count":208,"type":22},46,[25],"This randomized controlled trial compares two techniques for peri-implant soft tissue augmentation in the mandibular molar region: an autogenous connective tissue graft (CTG) and a collagen matrix. Adult patients requiring implant treatment with insufficient peri-implant soft tissue thickness will be randomly assigned to receive either CTG or a collagen matrix at the time of implant surgery.\n\nThe study aims to evaluate and compare changes in peri-implant soft tissue thickness, width of keratinized tissue, and soft tissue contour over a 9-month follow-up period, as well as the occurrence of postoperative complications. The results of this study will help determine whether a collagen matrix can provide clinical outcomes comparable to those of connective tissue grafting for peri-implant soft tissue augmentation.",[212,213],"Peri-implant Soft Tissue Deficiency","Insufficient Peri-implant Keratinized Tissue",[215,216,217,218],"Peri-implant soft tissue augmentation","Connective tissue graft","Collagen matrix","Dental implant","2026-01-27",{"date":221,"type":43},"2026-01-29",{"date":141,"type":22},{"date":143,"type":22},{"name":49,"class":50},{"id":226,"slug":227,"hasResults":11,"nctId":228,"briefTitle":229,"officialTitle":229,"acronym":4,"eligibilityCriteria":230,"healthyVolunteers":11,"sex":89,"minAge":4,"maxAge":4,"enrollmentInfo":231,"targetDuration":4,"studyType":23,"phases":233,"briefSummary":234,"conditions":235,"keywords":238,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":244,"lastUpdatePostDateStruct":245,"startDateStruct":247,"completionDateStruct":249,"leadSponsor":251,"locationsCount":4},"100607317","the-effectiveness-of-combined-pelvic-floor-muscle-training-and-vaginal-oestrogen-therapy-in-postmenopausal-women-with-stress-urinary-incontinence-100607317","NCT07186985","The Effectiveness of Combined Pelvic Floor Muscle Training and Vaginal Oestrogen Therapy in Postmenopausal Women With Stress Urinary Incontinence","Inclusion Criteria:\n\n* Patients diagnosed with stress urinary incontinence.\n* Women who have been naturally postmenopausal for at least 1 year or are postmenopausal due to bilateral oophorectomy (surgical removal of both ovaries).\n* Have had sexual intercourse to ensure feasibility of urogenital tract examination and assessment.\n* Patients who consent to participate in the study and comply with the treatment protocol, including performing pelvic floor muscle training (PFMT) and completing topical vaginal estrogen therapy.\n\nExclusion Criteria:\n\n* Patients with concomitant neurological disorders, urinary tract infections, prior pelvic radiotherapy, or congenital malformations of the lower urinary tract.\n* Genitourinary malformations or fistulas causing continuous urinary incontinence.\n* Genitourinary cancers or tumors of the urinary tract.\n* History of spinal cord injury or central nervous system injury affecting the centers that control urination.\n* Patients previously treated for stress urinary incontinence (SUI) (surgery, medications, exercises).\n* Patients with severe heart disease, coronary artery disease, or myocardial ischemia.\n* Patients with pelvic organ prolapse stage III or higher, unexplained vaginal bleeding, confirmed or suspected breast cancer, or vaginitis.\n* Presence of premalignant factors or suspected steroid-dependent cancers such as endometrial carcinoma.\n* History of or current hepatic tumors, or progressive liver or biliary disease.\n* Coagulation\u002Fthrombotic disorders, or a history of thromboembolism or stroke.\n* Severe hypertriglyceridemia.\n* Hypersensitivity to any component of vaginally administered estrogen products.\n* The patient or family members are unable to use a smartphone (Android or iOS) to participate in the monitoring program.\n* The patient does not agree to participate in the study.",{"count":232,"type":22},115,[25],"The objective of this clinical trial is to investigate whether the combination of pelvic floor muscle training (PFMT) and topical estrogen is more effective in treating stress urinary incontinence (SUI) in postmenopausal women compared to topical estrogen alone. The trial will also analyze factors related to the outcomes of the combined therapy. The key questions this trial aims to answer are:\n\n* Does the combination of PFMT and topical estrogen improve symptoms of stress urinary incontinence in postmenopausal women better than topical estrogen alone?\n* Which factors are associated with the effectiveness of the combined therapy?\n\nResearchers will compare the group receiving the combined therapy (pelvic floor muscle training plus topical estrogen) with the group receiving topical estrogen alone to determine whether adding PFMT to estrogen therapy provides additional treatment benefits for SUI in postmenopausal women.\n\nParticipants will:\n\n\\- Be randomly assigned to one of two groups:\n\nGroup 1: Undergo a pelvic floor muscle training (PFMT) program combined with topical estrogen therapy (e.g., vaginal cream\u002Fapplication,...).\n\nGroup 2: Receive topical estrogen therapy alone (e.g., vaginal cream\u002Fapplication,...).\n\n* Follow the assigned intervention protocol for a specified duration.\n* Attend regular clinic visits for clinical examinations, assessment of incontinence severity, and related measurements.\n* Monitor and record their incontinence symptoms and the frequency of urine leakage during daily activities.",[236,237],"Stress Urinary Incontinence (SUI)","Postmenopausal Women",[239,240,241,242,243],"stress urinary incontinence (SUI)","postmenopausal women","Pelvic Floor Muscle Training","Vaginal Oestrogen","Pelvic floor rehabilitation","2025-09-18",{"date":246,"type":43},"2025-09-22",{"date":248,"type":22},"2025-11-01",{"date":250,"type":22},"2027-02-28",{"name":49,"class":50},{"id":253,"slug":254,"hasResults":11,"nctId":255,"briefTitle":256,"officialTitle":256,"acronym":4,"eligibilityCriteria":257,"healthyVolunteers":258,"sex":59,"minAge":60,"maxAge":4,"enrollmentInfo":259,"targetDuration":4,"studyType":23,"phases":261,"briefSummary":262,"conditions":263,"keywords":266,"overallStatus":104,"whyStopped":4,"lastUpdateSubmitDate":272,"lastUpdatePostDateStruct":273,"startDateStruct":275,"completionDateStruct":277,"leadSponsor":279,"locationsCount":51},"100601679","adapting-an-evidence-based-intervention-to-improve-hiv-testing-and-prep-uptake-in-vietnam-100601679","NCT07113626","Adapting An Evidence-Based Intervention To Improve HIV Testing And PrEP Uptake In Vietnam","Inclusion Criteria:\n\n* Young men who have sex with men (YMSM):\n\nTheater testing. YMSM are eligible if they (1) are 18-24 years old Vietnamese male; (2) report having anal intercourse with another man in the last 6 months; (3) are HIV negative or of unknown HIV status; (4) own a smartphone; (5) currently live in Hanoi, (6) are able to read and understand Vietnamese without assistance, and (7) are willing to provide informed consent.\n\nBeta testing. Eligibility is similar to theater testing. Randomized controlled trial (RCT). YMSM are eligible if they (1) are 18-24 years old Vietnamese male; (2) report having anal intercourse with another man in the last 6 months; (3) are HIV negative or of unknown HIV status; (4) own a smartphone; (5) currently live in Hanoi, (6) are able to read and understand Vietnamese without assistance, and (7) are willing to provide informed consent and (8) are not being currently on pre-exposure prophylaxis (PrEP).\n\n* Other key stakeholders:\n\nEligibility criteria of this group are (1) having worked with MSM-related health issues at an HIV\u002FPrEP clinic or community-based organizations (CBO) for at least 6 months and (2) willingness to provide informed consent.\n\nExclusion Criteria:\n\n* Young men who have sex with men (YMSM):\n\nTheater testing. None Beta testing. Participants will be deemed ineligible if they are unwilling to provide contact information.\n\nRandomized controlled trial. Exclusion criteria include (1) unwilling to provide contact information; (2) currently enrolled in other HIV testing or PrEP program\u002Fintervention.\n\n* Other key stakeholders: None",true,{"count":260,"type":22},124,[25],"Young men who have sex with men are experiencing an ongoing HIV epidemic in Vietnam, with an HIV prevalence of 12%. However, HIV testing and pre-exposure prophylaxis (PrEP) use among young men who have sex with men remain low. To improve HIV testing and PrEP use, mobile health (mHealth) interventions hold great promise to reach young men who have sex with men in low- and middle-income countries. HealthMindr, an evidence-based mHealth intervention developed in the United States for men who have sex with men, is an ideal option for adaptation for young men who have sex with men in Vietnam. The specific aims are to (1) Adapt the HealthMindr app to improve HIV testing and PrEP uptake among young men who have sex with men in Vietnam; (2) Examine acceptability, feasibility and preliminary effectiveness of the adapted app among young men who have sex with men in Vietnam and (3) Explore barriers and facilitators of implementing the adapted app among young men who have sex with men in Vietnam. In Aim 1, theater testing will be conducted through focus group discussions with young men who have sex with men and key other stakeholders, including health officials, clinic staff and community-based organizations. Theater testing data will be used to refine the app for beta testing. During beta testing, a small group of young men who have sex with men will use the app for 30 days, then complete an online survey and an exit interview to rate the app's usability, provide their perspectives of the app and report any other areas for improvement. App analytics will also be collected to understand whether and how the app is used. In Aim 2, the adapted app with be tested among young men who have sex with men through a randomized controlled design. Young men who have sex with men will be randomized into the intervention or control arm (1:1 ratio). The intervention arm will have full access to the app for 3 months, while the control group will receive standard-of-care HIV services. Key app features include HIV test planning, risk and PrEP eligibility assessment, ordering of free condoms and HIV test kits, information about PrEP, and PrEP provider and HIV testing locations. HIV testing and PrEP use will be assessed at baseline and 3 months and compared between groups. A mixed methods approach will be used to evaluate app acceptability and feasibility. Quantitative data on acceptability and feasibility will be collected through the 3-month online survey, while qualitative data will be collected through in-depth interviews with a subset of young men who have sex with men in the intervention arm and other key stakeholders. In Aim 3, through the same qualitative study as Aim 2, factors that influence the implementation of the app will be explored. Determinants from seven domains will be identified: condition, technology, value proposition, adopter system, health organization, wider system and embedding\u002Fadaption over time. Only when mHealth interventions are both effective and adopted can they maximize their potential to reduce HIV incidence among target populations. This proposal will generate data for designing a full-scale hybrid type 1 effectiveness-implementation trial to test the adapted app and identify implementation strategies to address the barriers of app implementation in low and middle-income countries.",[264,265],"Intervention","Control Condition",[267,268,269,270,271,38],"young men who have sex with men","HIV\u002FAIDS","HIV testing","PrEP","mHealth","2025-08-17",{"date":274,"type":43},"2025-08-22",{"date":276,"type":43},"2025-01-15",{"date":278,"type":22},"2029-08-31",{"name":49,"class":50},{"id":281,"slug":282,"hasResults":11,"nctId":283,"briefTitle":284,"officialTitle":284,"acronym":285,"eligibilityCriteria":286,"healthyVolunteers":11,"sex":89,"minAge":60,"maxAge":4,"enrollmentInfo":287,"targetDuration":4,"studyType":23,"phases":289,"briefSummary":290,"conditions":291,"keywords":294,"overallStatus":104,"whyStopped":4,"lastUpdateSubmitDate":300,"lastUpdatePostDateStruct":301,"startDateStruct":303,"completionDateStruct":305,"leadSponsor":306,"locationsCount":51},"100576763","friendship-bench-for-women-who-use-methamphetamine-in-vietnam-100576763","NCT06789523","Friendship Bench for Women Who Use Methamphetamine in Vietnam","FB-WWUM","Inclusion Criteria:\n\n* Adult women (\\>=18 years old)\n* Moderate or greater risk for meth use (ASSIST ≥ 4)\n* Moderate or greater CMD symptom severity (Depression ≥ 10, Anxiety ≥ 8, and\u002For Stress ≥ 15 on DASS-21)\n\nExclusion Criteria:\n\n* Severe psychotic disorders or other interfering problems that require specialty care;\n* Inability to understand study procedures by the research team's judgment.",{"count":288,"type":22},100,[25],"The high comorbidity of mental health issues and meth use in women worsens both their mental health and meth use outcomes. The study team proposes to evaluate the potential of Friendship Bench to be used as a low-threshold, task-shifting mental health intervention among women who use methamphetamine in Vietnam - a lower-middle-income country. The study will provide preliminary data for a R01 trial testing the effectiveness Friendship Bench to improve mental health and methamphetamine use outcomes among women who use methamphetamine in Vietnam.",[292,293],"Methamphetamine Use","Common Mental Disorders (CMD)",[295,296,297,298,299],"methamphetamine","women who use drugs","common mental disorders","Friendship Bench","lay worker-delivered intervention","2025-08-06",{"date":302,"type":43},"2025-08-08",{"date":304,"type":43},"2025-06-11",{"date":278,"type":22},{"name":49,"class":50},{"id":308,"slug":309,"hasResults":11,"nctId":310,"briefTitle":311,"officialTitle":312,"acronym":4,"eligibilityCriteria":313,"healthyVolunteers":11,"sex":59,"minAge":60,"maxAge":314,"enrollmentInfo":315,"targetDuration":4,"studyType":23,"phases":317,"briefSummary":318,"conditions":319,"keywords":321,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":325,"lastUpdatePostDateStruct":326,"startDateStruct":328,"completionDateStruct":330,"leadSponsor":332,"locationsCount":51},"100591726","effectiveness-of-remote-cardiac-rehab-after-surgery-for-acquired-heart-valve-disease-100591726","NCT06984172","Effectiveness of Remote Cardiac Rehab After Surgery for Acquired Heart Valve Disease","Effectiveness of Cardiac Rehabilitation With Remote Connection Device for Patients After Surgery for Acquired Heart Valve Disease","Inclusion Criteria:\n\n* Patients undergoing first-time surgery for acquired heart valve diseases (valve replacement or repair), including the aortic valve, mitral valve, tricuspid valve, pulmonary valve, or a combination of these valves.\n* Willing to participate in the study.\n\nExclusion Criteria:\n\n* Contraindications to cardiac rehabilitation.\n* Patients who die during the study after hospital discharge.","70 Years",{"count":316,"type":22},44,[25],"The goal of this clinical trial is to learn if home-based cardiac rehabilitation using remote monitoring devices improves exercise capacity in patients after surgery for acquired heart valve diseases. It also aims to learn about factors affecting the outcomes of remote treatment.\n\nThe main questions it seeks to answer are:\n\n* How does cardiac rehabilitation using remote monitoring devices improve exercise capacity in participants compared to those undergoing rehabilitation at medical facilities?\n* What factors influence the outcomes of participants undergoing cardiac rehabilitation with remote monitoring devices? The researchers compare the exercise capacity of the intervention group - receiving home-based cardiac rehabilitation using remote monitoring devices - with that of the control group receiving treatment at a rehabilitation facility during the recovery phase.\n\nAll patients participating in the study receive inpatient cardiac rehabilitation during the acute phase (1 week) and the early recovery phase (1 week) at the hospital.\n\nThe control group continues supervised outpatient rehabilitation at the hospital, three sessions per week for the following month.\n\nThe intervention group undergoes home-based rehabilitation under the guidance of a therapist via the Open TeleRehab platform and self-monitors hemodynamic parameters using a personal blood pressure monitor and a handheld pulse oximeter.\n\nBoth groups are assessed for exercise capacity at baseline (pre-surgery), after each phase of rehabilitation, and one month after hospital discharge.",[320],"Valvular Diseases",[322,323,324],"phẫu thuật tim","phục hồi chức năng","valvular disease","2025-05-19",{"date":327,"type":43},"2025-05-22",{"date":329,"type":22},"2025-06-01",{"date":331,"type":22},"2026-06-30",{"name":49,"class":50},{"id":334,"slug":335,"hasResults":11,"nctId":336,"briefTitle":337,"officialTitle":337,"acronym":338,"eligibilityCriteria":339,"healthyVolunteers":11,"sex":59,"minAge":60,"maxAge":4,"enrollmentInfo":340,"targetDuration":4,"studyType":23,"phases":342,"briefSummary":343,"conditions":344,"keywords":349,"overallStatus":104,"whyStopped":4,"lastUpdateSubmitDate":358,"lastUpdatePostDateStruct":359,"startDateStruct":361,"completionDateStruct":363,"leadSponsor":365,"locationsCount":51},"100582081","effectiveness-of-auxiliary-segmental-lingual-appliances-in-leveling-the-curve-of-wilson-at-second-molars-100582081","NCT06858670","Effectiveness of Auxiliary Segmental Lingual Appliances in Leveling the Curve of Wilson at Second Molars","EASLALCW","Inclusion Criteria:\n\n* Patients undergoing labial fixed orthodontic treatment.\n* Patients exhibiting an excessive (deep) Curve of Wilson at the second molar bilaterally (meaning lingually inclined mandibular second molar).\n* Patients willing to participate and provide informed consent.\n\nExclusion Criteria:\n\n* Patients with limited mouth opening and gagging reflex preventing placement of auxiliary segmental lingual appliances.",{"count":341,"type":22},20,[25],"This study aims to evaluate the effectiveness of auxiliary segmental lingual appliances in leveling the Curve of Wilson at the second molars in patients undergoing labial fixed orthodontic treatment. Patients exhibiting an excessive (deep) Curve of Wilson at the second molar bilaterally (meaning lingually inclined mandibular second molar) will be recruited.. Using a split-mouth design, one side will receive the intervention (auxiliary segmental lingual appliances), while the other side will serve as the control. The variables measured include the Curve of Wilson at the second and first molars, and the distance from the mesiolingual and distolingual cusps of the second molar to the occlusal plane of the first molar. Measurements will be taken on digital impressions at baseline (T0), after leveling with a stainless steel labial archwire (T1), and three months after applying the auxiliary segmental lingual appliances. The effectiveness will be assessed by comparing the two groups.",[345,346,347,348],"Malocclusion","Malocclusion; Displaced or Missing Teeth","Malocclusions","Orthodontic Treatment",[350,351,352,353,354,355,345,356,357],"Auxiliary Segmental Lingual Appliances","Curve of Wilson","Second Molars","Labial Fixed Orthodontic Treatment","Split-Mouth Design","Digital Impressions","Dental Occlusion","Orthodontic Treatment Outcomes","2025-02-27",{"date":360,"type":43},"2025-03-05",{"date":362,"type":22},"2025-03-01",{"date":364,"type":22},"2029-03-01",{"name":49,"class":50},""]