[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Hartford Hospital\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":326},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,11,0,[8,45,73,105,132,167,189,212,238,259,288],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100553325","motivating-increases-in-physical-activity-for-prevention-of-weight-regain-after-metabolic-bariatric-surgery-100553325",false,"NCT06484621","Motivating Increases in Physical Activity for Prevention of Weight Regain After Metabolic Bariatric Surgery","Using Acceptance and Commitment Therapy to Promote Autonomous Motivation for Increased Physical Activity and Improved Weight Loss Maintenance in Bariatric Surgery Patients: A Randomized Trial","Inclusion Criteria:\n\n* Having undergone either a primary Roux-en-Y gastric bypass or sleeve gastrectomy bariatric procedure between 6 and 20 months prior to enrollment\n* Have reached their nadir weight and regained less than 10% of maximum weight lost based on weight measurements\n* Had their surgery performed at Hartford Hospital or another surgical weight loss center within the Hartford HealthCare system.\n* Able to provide consent\n* Willing to engage in and complete the study protocol\n* Able to safely participate in a physical activity program\n\nExclusion Criteria:\n\n* Have regained 10% or more of maximum weight lost based on weight measurements\n* Cannot ambulate independently\n* Do not speak\u002Fread English at a 6th grade level\n* Are pregnant, lactating, less than 6-months postpartum or plan to become pregnant during the course of the study\n* Report current involvement in a weight management program outside of standard care\n* Begin taking a newly prescribed medication for weight loss less than two months prior to study enrollment\n* Begin taking a newly prescribed medication or change the dosage\u002Ffrequency of pre-existing medications that are associated with weight loss\u002Fweight gain but not taken to produce weight loss less than two months prior to study enrollment\n* Report any conditions or plans that would preclude adherence to the study protocol (i.e., plans to relocate, psychiatric problems such as substance use disorder, or terminal illness)","ALL","18 Years","64 Years",{"count":20,"type":21},164,"ESTIMATED","INTERVENTIONAL",[24],"NA","The goal of this clinical trial is to learn if a psychological intervention can increase regular physical activity to help prevent weight regain after metabolic bariatric surgery in adults. The main questions it aims to answer are:\n\n1. Does the psychological intervention increase physical activity?\n2. Does the psychological intervention prevent weight regain?\n3. Does the psychological intervention increase internal motivation for physical activity and acceptance of the discomfort that can come with physical activity?\n\nResearchers will compare the psychological intervention to an educational intervention to see if the psychological intervention works to increase physical activity and prevent weight regain after metabolic bariatric surgery.\n\nParticipants will:\n\n* Complete 12 months of either the psychological or educational intervention. This includes attending online workshops with a small group of participants, completing brief homework assignments, and having individual telephone calls with a counselor.\n* Wear a device to measure physical activity, use an electronic scale to measure body weight, and complete questionnaires at home on five separate occasions over an 18-month period",[27],"Obesity",[29,30,31],"bariatric surgery","weight regain","physical activity","RECRUITING","2025-10-13",{"date":35,"type":36},"2025-10-15","ACTUAL",{"date":38,"type":36},"2024-08-08",{"date":40,"type":21},"2028-12-31",{"name":42,"class":43},"Hartford Hospital","OTHER",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":16,"minAge":53,"maxAge":54,"enrollmentInfo":55,"targetDuration":4,"studyType":22,"phases":57,"briefSummary":59,"conditions":60,"keywords":62,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":44},"100515794","phase-4-multifidus-cervicis-plane-block-vs-sham-block-for-posterior-cervical-spine-fusion-surgery-100515794","NCT05996133","Multifidus Cervicis Plane Block Vs. Sham Block For Posterior Cervical Spine Fusion Surgery","Comparing Multifidus Cervicis Plane Block Vs. Sham Block, In Reducing Postoperative Pain And Opioid Consumption In Patients Undergoing Elective Primary Posterior Cervical Spine Fusion Surgery","MCP","Inclusion Criteria:\n\n1. Patients 40-80 years old, males and females, of any race and any ethnic group.\n2. Patients are scheduled for elective primary posterior cervical spine fusion surgery (CSFS) to be performed by one of the spine surgeons in the study.\n3. Ability to speak and read English\n4. Patients with American Society of Anesthesiology (ASA) physical status score I- IV\n\nExclusion Criteria:\n\n1. Emergency posterior CSFS.\n2. Revision surgery or history of previous cervical spine surgery\n3. History of allergy to local anesthetics or steroids.\n4. Patients who are coagulopathic at the time of surgery\n5. Patients with contraindications to MCP blocks, including but not limited to anatomical abnormality or previous surgical intervention that limits or prevents receiving the blocks\n6. Infection at the site of the block.\n7. Weight \\\u003C 40 kg to avoid local anesthetic toxicity.\n8. Patients on chronic or continuous opioid use of \\> 50 MME (morphine milli-equivalent) per day for at least 30 days within 90 days prior to surgery.\n9. Patients with a history of chronic inflammatory conditions such as multiple sclerosis\n10. Refusal to participate or lack of providing the study consent","40 Years","80 Years",{"count":56,"type":21},38,[58],"PHASE4","The goal of this randomized, double-blinded, clinical trial is to assess the benefit of administering a Multifidus Cervicis Plane (MCP) block compared to a sham block as a method of postoperative pain control in patients undergoing posterior cervical spine fusion surgery. The main question it aims to answer is if the MCP block group will have reduced maximum pain scores during the first 24 postoperative hours compared to the sham block group.\n\nParticipants will receive preoperative bilateral MCP blocks on the back of their neck using the standard of care local anesthetic solution that consists of 30 mLs 0.25% Bupivacaine + 0.5 mL (5 mg) preservative-free Dexamethasone + 0.1 mL Epinephrine (MCP block group). Researchers will compare the MCP block to the preoperative sham block which consists of injecting 3 mL of normal saline into the same area (Sham block group) to compare the postoperative pain scores between the groups as a main objective. The secondary objectives are:\n\n* Postoperative opioid consumption during hospitalization and at 2 weeks after discharge.\n* The amount and type of non-opioid analgesics used during hospitalization.\n* The occurrence of postoperative nausea and vomiting (PONV) and the use of antiemetics.\n* Hospital and Post Anesthesia Care Unit length of stay (LOS).\n* Monitor the safety of the study interventions during hospitalization and readmissions within 30 days of discharge.\n* Patient satisfaction with pain management and overall satisfaction with the surgery experience.",[61],"Cervical Spine Fusion",[63,64],"Posterior cervical spine fusion surgery","Multifidus Cervicis Plane Block","2025-08-29",{"date":67,"type":36},"2025-09-05",{"date":69,"type":36},"2023-12-12",{"date":71,"type":21},"2027-06-30",{"name":42,"class":43},{"id":74,"slug":75,"hasResults":11,"nctId":76,"briefTitle":77,"officialTitle":78,"acronym":79,"eligibilityCriteria":80,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":54,"enrollmentInfo":81,"targetDuration":4,"studyType":22,"phases":83,"briefSummary":84,"conditions":85,"keywords":90,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":44},"100513941","phase-4-liposomal-bupivacainebupivacaine-in-rectus-sheath-blocks-versus-ropivacaine-in-rectus-sheath-blocks-and-catheters-100513941","NCT05972018","Liposomal Bupivacaine\u002FBupivacaine in Rectus Sheath Blocks Versus Ropivacaine in Rectus Sheath Blocks And Catheters","Liposomal Bupivacaine\u002FBupivacaine A Single-Dose Bilateral Rectus Sheath Blocks Versus Ropivacaine in Bilateral Rectus Sheath Blocks And Catheters With Intermittent Hourly Boluses.","EXODUS","Inclusion Criteria:\n\n1. Patients aged 18-80 years\n2. Patients scheduled for elective vascular surgery with an open mid-abdominal laparotomy incision, including abdominal aortic aneurysm repair surgery (AAA), mesenteric artery bypass surgery, and aortobifemoral bypass surgery for aortic occlusive disease.\n3. Patients who are able to speak and read English\n4. Patients with American Society of Anesthesiology (ASA) physical status score I-IV\n5. Patients who are admitted to the hospital and are incidentally discovered to require any of the aforementioned surgeries, being asymptomatic for vascular issues, and having their surgery scheduled no sooner than three days after admission, are also considered eligible.\n\nExclusion Criteria:\n\n1. Emergency vascular reconstruction surgery., patients admitted to the hospital due to symptoms directly associated with their vascular condition, such as severe abdominal pain or a ruptured aneurysm causing bleeding, will be excluded.\n2. Patients with contraindications to RSB, including but not limited to anatomical abnormality, previous surgical intervention that limits or prevents receiving bilateral RSBs, or infection at the injection site.\n3. History of allergy to local anesthetics.\n4. Weight \\\u003C 40 kg, as a combination of 20 mL of Bupivacaine 0.25% with 30 mL of LB is greater than the maximal dose allowed, given concern for local anesthetic toxicity.\n5. Patients who take long-acting opioid medication, or on continuous opioid use \\> 50 MME per day for at least 30 days within 90 days prior to surgery.\n6. Patients who have chronic pain syndrome with a recent preoperative consultation with the chronic pain service. Also, patients with distant metastatic cancers (e.g. bone, lung, brain) confirmed by CT scan.\n7. Patients with current substance abuse, or history of substance abuse within 3 months, this includes any illicit drugs (not including marijuana) or excessive alcohol consumption as defined as 4 or more drinks per day or 8 or more drinks per week for women and 5 or more drinks per day or 15 or more drinks per week for men.\n8. Lack or refusal to sign the study consent.\n9. Patients who are unable to receive postoperative ropivacaine intermittent boluses within the first 5 days after surgery due to issues with their catheter (such as dislodgement, migration, or kinking) will be excluded from the final analysis.\n10. Patients with a plan to undergo abdominal wall surgery, in addition to the vascular surgery that involves a mid-abdomen incision, such as abdominal wall reconstruction surgery. The additional abdominal wall incisions or interventions might have an impact on the study's pain, opioid, and LOS outcomes.",{"count":82,"type":21},14,[58],"The goal of this pilot study is to compare single shot rectus sheath blocks of liposomal bupivacaine\u002Fbupivacaine mixture to bilateral rectus sheath catheters infused with ropivacaine (standard of care at our facility) in patients undergoing vascular surgery with an open mid-abdominal laparotomy incision. This study will assess the safety and feasibility of this approach compared to standard of care.\n\nParticipants will receive either a single dose of liposomal bupivacaine\u002Fbupivacaine mixture intraoperatively at the end of surgery through bilateral rectus sheath blocks (LB\u002FB group) or the standard of care ropivacaine intraoperatively at the end of surgery through bilateral rectus sheath blocks with the insertion of bilateral RS catheter for continuous ropivacaine infusion plus repeated daily boluses (Catheter group; standard care). They will be assessed for differences in the rate of postoperative complications, resources consumed with each intervention, as well as postoperative pain scores, opioid consumption, hospital and PACU length of stay, patient's satisfaction, and quality of recovery, and hospital length of stay.",[86,87,88,89],"Aortic Aneurysm, Abdominal","Abdominal Aortic Occlusion","Aortoiliac Occlusive Disease","Aortic Diseases",[91,92,93,94,95,96],"Open abdominal aortic repair surgery","Rectus Sheath Block","Rectus Sheath Block and Catheter","Liposomal Bupivacaine","Exparel","Ropivacaine continuous infusion","2025-08-28",{"date":99,"type":36},"2025-09-03",{"date":101,"type":36},"2023-10-18",{"date":103,"type":21},"2026-12-30",{"name":42,"class":43},{"id":106,"slug":107,"hasResults":11,"nctId":108,"briefTitle":109,"officialTitle":110,"acronym":111,"eligibilityCriteria":112,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":113,"targetDuration":4,"studyType":22,"phases":115,"briefSummary":116,"conditions":117,"keywords":119,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":124,"lastUpdatePostDateStruct":125,"startDateStruct":127,"completionDateStruct":129,"leadSponsor":131,"locationsCount":44},"100456476","phase-4-bilateral-tap-and-rs-blocks-using-liposomal-bupivacainebupivacaine-vs-regular-bupivacaine-in-laparoscopic-colectomy-100456476","NCT05224089","Bilateral TAP and RS Blocks Using Liposomal Bupivacaine\u002FBupivacaine vs. Regular Bupivacaine in Laparoscopic Colectomy","Bilateral Mid-Abdominal Transverse Abdominis Plane and Rectus Sheath Blocks Comparing The Use of Liposomal Bupivacaine\u002FBupivacaine vs. Regular Bupivacaine in Laparoscopic Colectomy Procedures.","TAPLIP","Inclusion Criteria:\n\n* Patients scheduled for elective laparoscopic colectomy surgery to be performed by one of the 4 colorectal surgeons in the study.\n* English speaking patients\n* Patients with American Society of Anesthesiology (ASA) physical status score I- IV\n\nExclusion Criteria:\n\n1. Emergency laparoscopic colectomy surgery\n2. Patients with distant metastatic cancers (e.g. bone, lung, brain).\n3. Scheduled for multi organs resection surgery in addition to colectomy.\n4. Patients with contraindications to TAP or RS blocks including but not limited to anatomical abnormality, previous surgical intervention that limits or prevents receiving bilateral TAP blocks (e.g. surgical mesh at the site of TAP or RS block), or infection at the injection site.\n5. Current colostomies.\n6. History of allergy to local anesthetics.\n7. Coagulopathy or coagulation disorder. Also patients who are receiving antithrombotic medications as a contraindication to receiving single shot peripheral nerve blockade as per the most recent American Society of Regional Anesthesiology (ASRA) guidelines.16\n8. Weight \\\u003C 40 kg, as 40 mL of Bupivacaine 0.25%, or combination of 20 mL of bupivacaine 0.25% with 20 mL of liposomal bupivacaine is greater than the maximal dose allowed, given concern for local anesthetic toxicity.\n9. Patients who take long acting opioid medication, or on continuous opioid \\> 50 MME per day for at least 30 days within 90 days prior to surgery. Also patients who have chronic pain syndrome with a recent preoperative consultation to the chronic pain service.\n10. Patients with current substance abuse, or history of substance abuse within 3 months, this includes any illicit drugs or excessive alcohol consumption as defined 4 or more drinks per day or 8 or more drinks per week for women and 5 or more drinks per day or 15 or more drinks per week for men.15\n11. Pregnant, nursing, or planning to become pregnant during the study or within 1 month postoperatively\n12. Refusal or lack of providing the study consent",{"count":114,"type":21},114,[58],"This study will be a single center, prospective triple blinded randomized controlled study, comparing the use of liposomal bupivacaine (Exparel) to regular bupivacaine with adjuncts in bilateral mid-abdominal transverse abdominis plane (TAP) blocks for patients undergoing laparoscopic colectomy procedures.",[118],"Bowel Disease",[94,95,120,121,122,123,92],"Bupivacaine","Laparoscopic Colectomy","Transverse Abdominis Plane Blocks (TAP)","Regional anesthesia","2025-03-28",{"date":126,"type":36},"2025-04-02",{"date":128,"type":36},"2022-04-27",{"date":130,"type":21},"2026-02",{"name":42,"class":43},{"id":133,"slug":134,"hasResults":11,"nctId":135,"briefTitle":136,"officialTitle":137,"acronym":4,"eligibilityCriteria":138,"healthyVolunteers":139,"sex":16,"minAge":17,"maxAge":53,"enrollmentInfo":140,"targetDuration":4,"studyType":22,"phases":142,"briefSummary":144,"conditions":145,"keywords":149,"overallStatus":159,"whyStopped":4,"lastUpdateSubmitDate":160,"lastUpdatePostDateStruct":161,"startDateStruct":163,"completionDateStruct":165,"leadSponsor":166,"locationsCount":4},"100428168","early-phase-1-thc--cbd-and-memory-study-100428168","NCT04855526","THC + CBD and Memory Study","Effects of Marijuana on Memory-Related Neurochemistry and Neural Response","Inclusion Criteria:\n\n* Right-handed\n* Prior MJ users (has used MJ at least once in the past year, but no more than 1x\u002Fmonth in the past 12 months)\n* Medically healthy (as determined by medical history and treatment)\n* Adequate comprehension of English in order to complete study materials\n* Acceptable birth control method for women (i.e., no copper IUD or any device that is not MRI safe)\n\nExclusion Criteria:\n\n* Participant currently uses psychoactive medications or substances\n* Psychiatric diagnoses (determined by DSM-V)\n* Participant heavily or regularly uses MJ (more than 1x\u002Fmonth in the past year)\n* Current or past substance dependence (including MJ)\n* Positive urine toxicology screens\n* Positive pregnancy screens\n* MRI contraindications (e.g., heart pacemaker)",true,{"count":141,"type":21},9,[143],"EARLY_PHASE1","Memory deficits are one of the most consistently observed cognitive effects of marijuana use. There is evidence that some decrements attributable to the primary psychoactive ingredient, delta-9-tetrahydrocannabinol (THC), may be attenuated by cannabidiol (CBD). This study will help us learn more about the relationship between THC and CBD consumption with memory processes. A combination of MRI and neuropsychological tests (which are computer and paper\u002Fpencil tasks) will be used to measure the neurocognitive and behavioral impacts of THC and CBD use.",[146,147,148],"Marijuana Use","Cannabis Use","Cannabis Intoxication",[150,151,152,153,154,155,156,157,158],"marijuana","cannabidiol","memory","THC","cannabis","intoxication","MRI","glutamate","MRS","NOT_YET_RECRUITING","2025-03-13",{"date":162,"type":36},"2025-03-17",{"date":164,"type":21},"2025-12-01",{"date":103,"type":21},{"name":42,"class":43},{"id":168,"slug":169,"hasResults":11,"nctId":170,"briefTitle":171,"officialTitle":172,"acronym":4,"eligibilityCriteria":173,"healthyVolunteers":139,"sex":16,"minAge":174,"maxAge":17,"enrollmentInfo":175,"targetDuration":4,"studyType":22,"phases":177,"briefSummary":178,"conditions":179,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":181,"lastUpdatePostDateStruct":182,"startDateStruct":184,"completionDateStruct":186,"leadSponsor":188,"locationsCount":44},"100550377","target-adhd-executive-working-memory-replication-study-100550377","NCT06446284","Target ADHD Executive Working Memory Replication Study","Behavioral and Neural Target Engagement for ADHD Executive Working Memory Training","Inclusion Criteriia:\n\n* Diagnosis of ADHD\n* English speaking\n* Right-handed\n* \\>5th grade reading level\n* \\>80 IQ level\n\nExclusion Criteria:\n\n* Braces, metal or implant devices\n* Brain abnormality, neurological disorder\n* TBI or loss of consciousness\\>30 minutes\n* Diagnosis of Psychosis, Bipolar Disorder, ASD, PTSD, OCD, SUD, Tourette's Disorder","12 Years",{"count":176,"type":21},130,[24],"The proposed study will replicate target engagement as assessed in the first phase while also determining if it correlates with clinically meaningful improvements in ADHD dysfunction",[180],"ADHD","2025-03-03",{"date":183,"type":36},"2025-03-04",{"date":185,"type":36},"2023-12-01",{"date":187,"type":21},"2026-12-01",{"name":42,"class":43},{"id":190,"slug":191,"hasResults":11,"nctId":192,"briefTitle":193,"officialTitle":193,"acronym":194,"eligibilityCriteria":195,"healthyVolunteers":11,"sex":16,"minAge":196,"maxAge":197,"enrollmentInfo":198,"targetDuration":4,"studyType":22,"phases":200,"briefSummary":201,"conditions":202,"keywords":4,"overallStatus":159,"whyStopped":4,"lastUpdateSubmitDate":204,"lastUpdatePostDateStruct":205,"startDateStruct":207,"completionDateStruct":209,"leadSponsor":211,"locationsCount":44},"100559248","testing-a-brief-exercise-intervention-in-hoarding-disorder-100559248","NCT06561659","Testing a Brief Exercise Intervention in Hoarding Disorder","Exercise BDNF","Inclusion Criteria:\n\n* Primary diagnosis of hoarding disorder\n* Age 45-65 years\n\nExclusion Criteria:\n\n* Contraindications to engaging in exercise, including cardiovascular, metabolic, or renal disease, thyroid problems, uncontrolled hypertension\n* Significant mobility issues that would preclude brisk walking\n* Schizophrenia, bipolar disorder, serious suicidal risk, active substance use disorder, and cognitive impairment that may preclude the ability to provide informed consent and\u002For participate in study procedures","45 Years","65 Years",{"count":199,"type":21},22,[24],"Hoarding disorder (HD) is characterized by difficulty discarding personal possessions due to significant emotional distress when parting with personal items. This leads to the accumulation of excessive clutter which compromises the normal use of living spaces. In addition to emotional distress, individuals with HD experience significant impairment in physical health. One study found an 11-fold increase in stroke risk, a 10-fold increase in cancer risk, and a 7-fold increase in cardiovascular disease in individuals with HD relative to a general population comparison group. Patients with HD are also more likely to experience obesity and metabolic diseases such as diabetes. The short-term goal of the proposed study is to determine whether a brief exercise intervention improves discarding-related distress and brain-derived neurotropic factor (BDNF) in individuals with HD relative to a relaxation control condition. Preliminary evidence suggests that BDNF may be associated with greater body mass index and more severe HD symptoms in patients with HD. BDNF is a well-studied growth factor which is involved in neuronal transmission, plasticity, and survival of many neuron systems that have been implicated in psychiatric disorders, including serotonin, glutamate, and dopamine. BDNF has been proposed as a mechanism of exercise interventions for psychiatric disorders, as even one session of exercise has been shown to increase BDNF levels. This study represents an initial first step towards the long-term goal of improving current treatments for HD. This is important because although current cognitive-behavioral treatments (CBT) are effective, only 35% of patients who receive these treatments actually benefit from them. In the proposed pilot study, the investigators will test whether 30 minutes of moderate-intensity exercise reduces the distress associated with discarding and increases BDNF levels in individuals with HD relative to a relaxation control. The investigators will recruit 22 individuals with a primary diagnosis of HD. They will be randomly assigned to exercise or control. Following the intervention, the investigators will assess BDNF via serum. Participants will complete a standardized discarding task which consists of sorting and discarding personal possessions. The central hypothesis is that those in the exercise condition will demonstrate lower distress during the discarding task and greater BDNF levels as compared to those in the relaxation control condition. Should the hypothesis be confirmed, the investigators will be well poised to conduct large-scale clinical trials testing exercise interventions as adjunctive or alternative treatments to standard CBT.",[203],"Hoarding Disorder","2024-08-15",{"date":206,"type":36},"2024-08-20",{"date":208,"type":21},"2024-10",{"date":210,"type":21},"2025-12",{"name":42,"class":43},{"id":213,"slug":214,"hasResults":11,"nctId":215,"briefTitle":216,"officialTitle":217,"acronym":4,"eligibilityCriteria":218,"healthyVolunteers":11,"sex":16,"minAge":219,"maxAge":197,"enrollmentInfo":220,"targetDuration":4,"studyType":22,"phases":222,"briefSummary":223,"conditions":224,"keywords":226,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":229,"lastUpdatePostDateStruct":230,"startDateStruct":232,"completionDateStruct":234,"leadSponsor":236,"locationsCount":237},"100506648","improving-availability-of-intranasal-naloxone-100506648","NCT05877118","Improving Availability of Intranasal Naloxone","Improving Availability of Intranasal Naloxone Rescue for Opioid Overdose","Inclusion Criteria:\n\n-Patients will be in the process of being discharged from Hartford Hospital ED with a naloxone kit prescription following opiate or opioid intoxication\u002Fpoisoning, use of illicit opioids or prescription opioids, or opioid injection use-related conditions\n\nExclusion Criteria:\n\n* Patient has previously received the standard naloxone kit education or has a known allergy to naloxone and\u002For kit constituents\n* Patient or support network does not speak English\n* Patient is in police custody\n* Patient is not being discharged home from the ED.","21 Years",{"count":221,"type":21},84,[24],"While there is a lifesaving medication called naloxone that can reverse the deadly effects of opioid overdose, patients often fail to fill the prescription at the pharmacy when it is prescribed. This is particularly concerning and true in those at the highest risk of death-those who end up in the emergency department for opioid overdose. The goal of this study is to compare the impact of different overdose education on naloxone prescription fill rates in opioid users being discharged from our hospital emergency department. You will receive either (a) written education about naloxone through their MyChart account, or (b) a concise one-page handout and 4-minute video clip reviewed with the participant and a support individual (family\u002Ffriend) prior to discharge.",[225],"Opioid Overdose",[227,228],"Naloxone","Overdose education","2024-06-06",{"date":231,"type":36},"2024-06-07",{"date":233,"type":36},"2024-03-01",{"date":235,"type":21},"2025-12-31",{"name":42,"class":43},2,{"id":239,"slug":240,"hasResults":11,"nctId":241,"briefTitle":242,"officialTitle":243,"acronym":244,"eligibilityCriteria":245,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":246,"enrollmentInfo":247,"targetDuration":4,"studyType":22,"phases":249,"briefSummary":250,"conditions":251,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":252,"lastUpdatePostDateStruct":253,"startDateStruct":254,"completionDateStruct":256,"leadSponsor":258,"locationsCount":44},"100550310","tai-chi-as-a-novel-strategy-to-increase-physical-activity-among-adults-pursuing-metabolic-and-bariatric-surgery-100550310","NCT06445413","Tai Chi as a Novel Strategy to Increase Physical Activity Among Adults Pursuing Metabolic and Bariatric Surgery","Tai Chi as a Novel Strategy to Increase Physical Activity Among Adults Pursuing Metabolic and Bariatric Surgery: A Feasibility and Acceptability Study","ACHIEVE","Inclusion Criteria:\n\n1. Seeking to undergo MBS at HHC.\n2. Be able to give valid informed consent in English. Attending the live, in-person, group TC classes each week is the main component of the intervention. During the classes, the TC instructor will be giving instructions and communicating with the participants in English. It is not practical to having an interpreter during the live classes. Therefore, participation is limited to those who are English speakers.\n3. Be 18-70 years of age.\n4. Have BMI≥35 kg\u002Fm2\n5. Absence of cognitive impairment since participants will need to learn and memorize the TC forms. Must score ≥24 Mini-Mental State Examination.\n6. Be physically inactive defined as performing \\\u003C150 min\u002Fwk of moderate to vigorous intensity PA based on self-report.\n7. Be able to ambulate independently without use of an assistive device.\n8. Be able to complete questionnaires and view TC instructional videos via REDCap.\n9. Be able to commute to one of the HH Medical and Surgical Weight Loss Center clinics to participate in testing sessions and in-person TC classes.\n\nExclusion Criteria:\n\n1. Having severe psychological or physical conditions that may impair their ability to adhere to the study protocol such as uncontrolled mental health issues, and severe arthritis.\n2. Pregnant women.","70 Years",{"count":248,"type":21},24,[24],"The goal of this clinical trial is to evaluate the feasibility and acceptability of a 10-wk hybrid Tai Chi (TC) program with in-person classes and online TC videos among 24 physically inactive adults who are seeking metabolic and bariatric surgery (MBS) in a single-arm trial.\n\nThe aims are:\n\nAim 1: Feasibility: To evaluate whether TC is feasible, defined as a mean attendance rate of ≥70% in-person TC classes attended.\n\nAim 2: Acceptability: To evaluate whether TC is acceptable, defined as a mean rating of ≥4 across 4 acceptability questionnaire items measured on a 5-point Likert scale (e.g., rate \"Tai Chi practice is appealing to me\" on a scale from 1 \\[completely disagree\\] to 5 \\[completely agree\\]).\n\nParticipants will complete four individual in-person visits where they will complete study assessments and ten weekly group in-person Tai Chi classes where they will practice Tai Chi with up to 5 other study participants. Additionally, they will be asked to practice Tai Chi at home with the aid of instructional online videos and log their practice.",[27],"2024-06-04",{"date":229,"type":36},{"date":255,"type":36},"2024-01-22",{"date":257,"type":21},"2025-06-30",{"name":42,"class":43},{"id":260,"slug":261,"hasResults":11,"nctId":262,"briefTitle":263,"officialTitle":264,"acronym":265,"eligibilityCriteria":266,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":267,"enrollmentInfo":268,"targetDuration":4,"studyType":22,"phases":270,"briefSummary":271,"conditions":272,"keywords":274,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":280,"lastUpdatePostDateStruct":281,"startDateStruct":283,"completionDateStruct":285,"leadSponsor":287,"locationsCount":44},"100521374","phase-4-etomidate-versus-propofol-in-cabg-surgery-100521374","NCT06068764","Etomidate Versus Propofol in CABG Surgery","Etomidate Versus Propofol As An Anesthesia Induction Agent For Patients Undergoing CABG Surgery, Assessing Hemodynamic Stability. A Single Blinded, Randomized Controlled Trial.","ETOPRO","Inclusion Criteria:\n\n1. Patients scheduled for elective open coronary arteries bypass graft CABG surgery\n2. Patients with American Society of Anesthesiology (ASA) physical status score I- IV\n3. Patients with the ability to speak and read both English and Spanish\n\nExclusion Criteria:\n\n1. Emergency CABG surgery, STAT cases, and add-on cases.\n2. Refusal or lack of providing the study consent\n3. Patients with a known current adrenocortical insufficiency\n4. A patient who is presenting with any kind of shock, (e.g. septic, hypovolemic, cardiogenic, etc.)\n5. Patients with chronic steroid use (defined as the use of glucocorticoids within 6 months preoperatively)\n6. Patients with a known allergy to etomidate or propofol.\n7. Patients with a known seizure disorder.\n8. Patients who are enrolled in other clinical research studies that can compete with this study.","90 Years",{"count":269,"type":21},300,[58],"The objective of this single-blinded randomized controlled interventional clinical trial is to learn about the efficacy and long-term safety of etomidate compared to propofol as an anesthesia induction agent in patients undergoing coronary artery bypass graft (CABG) surgery. The primary aim of this study is to determine whether patients receiving etomidate or propofol exhibit similar requirements for vasopressor or ionotropic agents during both the intraoperative and postoperative periods.\n\nTo achieve this goal, participants who are scheduled for CABG surgery will be randomly assigned to receive either etomidate or propofol as the principal hypnotic agent. The researchers will then compare the effects of these two anesthesia induction agents on various factors, including the need for hemodynamic support, hemodynamic stability, duration of mechanical ventilation, length of stay in the intensive care unit (ICU), and overall hospital length of stay. Additionally, they will assess whether there are disparities in mortality rates and readmission rates within a 6-month timeframe after the surgery.\n\nBy comparing the outcomes between the two groups, the study aims to provide valuable insights into the potential differences in vasopressor or ionotropic agent requirements between etomidate and propofol. This information can help inform clinical decision-making and potentially optimize anesthesia management strategies for patients undergoing CABG surgery.",[273],"Coronary Artery Disease",[275,276,277,278,279],"CABG surgery","Etomidate","Propofol","general anesthesia induction agenats","cardiothoracic anesthesia","2023-12-27",{"date":282,"type":36},"2023-12-28",{"date":284,"type":36},"2023-12-05",{"date":286,"type":21},"2026-08",{"name":42,"class":43},{"id":289,"slug":290,"hasResults":11,"nctId":291,"briefTitle":292,"officialTitle":293,"acronym":4,"eligibilityCriteria":294,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":295,"enrollmentInfo":296,"targetDuration":4,"studyType":22,"phases":298,"briefSummary":299,"conditions":300,"keywords":307,"overallStatus":159,"whyStopped":4,"lastUpdateSubmitDate":318,"lastUpdatePostDateStruct":319,"startDateStruct":321,"completionDateStruct":323,"leadSponsor":325,"locationsCount":44},"100502624","depuy-synthes-variable-angle-lcp-patella-plating-system-study-100502624","NCT05824676","DePuy Synthes Variable Angle LCP Patella Plating System Study","Utility of the Variable Angle LCP Patella Plating System for Traumatic Patellar Fractures: A Randomized Control Trial","Inclusion Criteria:\n\n* Males and females\n* Age between 18 and 74 years old (inclusive)\n* Patellar fracture\n* Treated at Hartford HealthCare The Bone and Joint Institute or Hartford Hospital\n\nExclusion Criteria:\n\n* Age greater than or equal to 75 or less than 18\n* Patients that are non-ambulatory\u002Flimited ambulation prior to their injury\n* Previous patellar fracture\n* Pre-existing osteoarthritis of the knee\n* Ipsilateral femoral or tibia fractures","74 Years",{"count":297,"type":21},36,[24],"The Depuy Synthes Locking Compression Plate (LCP) Variable Angle Patella Plating System is an FDA approved device. The purpose of this study is to see how well the Depuy Synthes LCP Variable Plating System work in fixing a broken kneecap (patella). Depuy says that the device will improve healing when compared to traditional ways of repairing a broken patella.\n\nThe goal of this randomized control trial is to learn how well the LCP Variable Plating System works to fix a broken patella (kneecap) compared to traditional fixation methods, in male and females, age 18 to 74, with a patellar fracture, and being treated at Hartford HealthCare The Bone and Joint Institute or Hartford Hospital. The main question it aims to answer are:\n\n* To understand if the Depuy Synthes LCP Variable Angle Plating System will provide a better way to help patients recover from a broken patella.\n\nParticipants will evaluated at specific time points: post-op day 1, 6 weeks, 3 months, 6 months, and 12 month post-surgery. Participants will be asked to:\n\n* Complete surveys at all evaluation timepoints.\n* Have x-rays(radiographs) taken at the 6 week, 3 month, 6 month, 9 month, and 1 year timepoints.\n* Participants will have a passive range of motion tests done at 6 week, 3 month, 6 month, 9 month, and 1 year timepoints.\n* Participants would have strength and balance tests done at the 3 month, 6 month, 9 month, and 1 year timepoints.",[301,302,303,304,305,306],"Trauma","Patella Fracture","Knee Cap","Knee Cap Injury","Knee Discomfort","Knee Deformity",[308,309,310,311,312,313,314,315,316,317],"Patella","Plating","trauma","kneecap","injury","knee injuries","knee injury","fracture","break","randomized","2023-04-10",{"date":320,"type":36},"2023-04-21",{"date":322,"type":21},"2023-05",{"date":324,"type":21},"2027-12",{"name":42,"class":43},""]