[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Harvard School of Public Health (HSPH)\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":269},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,8,0,[8,42,97,122,159,191,219,243],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":4},"100640657","community-gateway-to-health-study-100640657",false,"NCT07592793","Community Gateway to Health Study","Study participants include community health center and community partner staff participating in surveys and interviews about the implementation of the intervention.\n\nInclusion Criteria:\n\n* Community health center staff or community partners\n* Age 18 or older\n\nExclusion Criteria:\n\n* Under 18\n\nPatients will not be individually recruited for the study because the intervention is being offered as part of routine care.",true,"ALL","18 Years",{"count":19,"type":20},100,"ESTIMATED","INTERVENTIONAL",[23],"NA","The goal of this study is to evaluate the impact of a multi-level intervention on cancer prevention and social determinants of health outcomes. This partnership between academic and community-based researchers aims to link community health centers and communities in ways that maximize both civic engagement and participation in cancer control care. The system-level intervention consists of two components: (1) provision of community health center systems-level tools for cancer screening (breast, cervical, colorectal) and tobacco cessation treatment gaps; and (2) digital access screening and navigation. These interventions will be delivered via usual care.",[26,27,28,29],"Breast Cancer Screening","Cervical Cancer Screening","Colon Cancer Screening","Tobacco Cessation","NOT_YET_RECRUITING","2026-05-11",{"date":33,"type":34},"2026-05-18","ACTUAL",{"date":36,"type":20},"2026-06",{"date":38,"type":20},"2029-07",{"name":40,"class":41},"Harvard School of Public Health (HSPH)","OTHER",{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":48,"eligibilityCriteria":49,"healthyVolunteers":15,"sex":16,"minAge":50,"maxAge":51,"enrollmentInfo":52,"targetDuration":4,"studyType":54,"phases":4,"briefSummary":55,"conditions":56,"keywords":73,"overallStatus":87,"whyStopped":4,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":96},"100346729","psychosocial-environmental-and-chronic-disease-trends-in-puerto-rico-100346729","NCT03794531","Psychosocial, Environmental, and Chronic Disease Trends in Puerto Rico","Puerto Rico Observational Study of Psychosocial, Environmental, and Chronic Disease Trends","PROSPECT","Inclusion Criteria:\n\n1. Age 30-75 years old at the time of enrollment\n2. Non-institutionalized\n3. Living in PR at the time of the first interview and the year before and not planning to move from the island within 3 years\n4. Able to answer questions without assistance\n5. Living in a stable dwelling\n\nExclusion Criteria:","30 Years","75 Years",{"count":53,"type":20},2500,"OBSERVATIONAL","The overall goal is to identify trends and longitudinal associations in psychosocial, food-related, and cardiometabolic risk factors that can guide public health priorities and future research needs aimed at reducing cardiovascular-related disparities in Puerto Rico. To this end, investigators will establish 'PROSPECT: Puerto Rico Observational Study of Psychosocial, Environmental, and Chronic disease Trends', an island-wide, longitudinal population cohort of 2,500 adults (30-75 years) in PR recruited with a community-wide sampling strategy, and assessed in a network of several partner clinics across the island. The study will collect comprehensive data on multiple psychosocial, dietary, and food-related factors, CVD biological markers, and medical record data, with follow-up at 2-years, and will assess variations by urban-rural area and by timing before-after Maria.",[57,58,59,60,61,62,63,64,65,66,67,68,69,70,71,72],"Heart Diseases","Type2 Diabetes","Hypertension","Obesity","Dyslipidemias","Metabolic Syndrome","Cardiovascular Diseases","Chronic Disease","Inflammation","Psychological Stress","Physiological Stress","Depressive Symptoms","Coping Behavior","Diet Habit","Lifestyle","Food Insecurity",[74,75,76,77,78,79,80,81,82,83,84,85,86],"Hispanics\u002FLatinos","Minority health","Puerto Rico","Cardiovascular disease","Cardiometabolic health","Chronic disease risk factors","Disaster research","Caribbean and Latin America","Population health","Prospective study","Allostatic load","Food insecurity","Longitudinal study","RECRUITING","2026-04-30",{"date":90,"type":34},"2026-05-05",{"date":92,"type":34},"2019-03-01",{"date":94,"type":20},"2029-04-30",{"name":40,"class":41},1,{"id":98,"slug":99,"hasResults":11,"nctId":100,"briefTitle":101,"officialTitle":101,"acronym":102,"eligibilityCriteria":103,"healthyVolunteers":15,"sex":16,"minAge":104,"maxAge":105,"enrollmentInfo":106,"targetDuration":4,"studyType":21,"phases":108,"briefSummary":109,"conditions":110,"keywords":112,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":114,"lastUpdatePostDateStruct":115,"startDateStruct":117,"completionDateStruct":119,"leadSponsor":121,"locationsCount":96},"100630907","multiple-micronutrient-supplementation-with-digital-layering-among-adolescents-in-tanzania-100630907","NCT07493772","Multiple Micronutrient Supplementation With Digital Layering Among Adolescents in Tanzania","MMSDigitalTZ","Inclusion Criteria:\n\n* Aged 15-19 years at enrollment.\n* Resident in the Dar es Salaam HDSS coverage area.\n* Has access to at least one phone (own or shared within the household; feature phone or smartphone).\n* Demonstrates basic literacy skills sufficient to understand simple written messages.\n* Has capacity to provide informed consent (for those ≥18 years) or assent (for those \\\u003C18 years, with parental\u002Fguardian consent).\n\nExclusion Criteria:\n\n* Currently pregnant.\n* Enrolled in the ARISE-NUTRINT trial.\n* Currently taking iron and folic acid or multiple micronutrient tablets for anemia outside this study.\n* Known to have HIV infection at the time of screening.\n* More than one eligible adolescent per household: if multiple adolescents meet criteria in a household, one will be randomly selected to participate.","15 Years","19 Years",{"count":107,"type":20},1200,[23],"This study is a three-arm, individually randomized controlled trial evaluating the impact of digitally delivered nutrition education, layered onto multiple micronutrient supplementation (MMS), on anemia and related health behaviors among adolescents in Dar es Salaam, Tanzania. A total of 1,200 adolescents aged 15-19 years with access to a phone (own or shared) will be enrolled from the Dar es Salaam Health and Demographic Surveillance System and followed for 9 months, with assessments at baseline, 4 months, and 9 months.\n\nAll participants will receive a brief in-person nutrition education session, printed brochures on adolescent nutrition and anemia, and a 2-month supply of daily MMS tablets with instructions and access to refills (Control arm). In Intervention Arm I, participants will receive the same package plus weekly one-way SMS\u002FWhatsApp messages reinforcing key nutrition content and adherence to MMS and refills. In Intervention Arm II, participants will receive all components of Arm I plus fortnightly, in-person group digital nutrition education sessions that include interactive content and opportunities to co-create and share digital nutrition messages with peers. All participants will receive information on replenishing the tablets. Participants in Intervention Arm I and Intervention Arm II will receive additional nutrition, diet, and physical activity-related messages along with reminders and motivational encouragement to replenish their supplement stocks.\n\nThe primary outcome is anemia prevalence, assessed using hemoglobin concentration and WHO age- and sex-specific cutoffs. Secondary outcomes include moderate\u002Fsevere anemia, hemoglobin levels, adherence to MMS pick-up and consumption, nutrition literacy, dietary diversity, fruit and vegetable intake, physical activity, underweight\u002Foverweight\u002Fobesity, and digital literacy. The trial also includes a mixed-methods process evaluation of feasibility, acceptability, reach, engagement with the digital components, and a cost estimation of the digital strategies.",[111],"Anemia",[113],"Adolescents, multiple micronutrient supplements, RCT, Tanzania","2026-03-20",{"date":116,"type":34},"2026-03-25",{"date":118,"type":20},"2026-05-01",{"date":120,"type":20},"2027-03-31",{"name":40,"class":41},{"id":123,"slug":124,"hasResults":11,"nctId":125,"briefTitle":126,"officialTitle":127,"acronym":128,"eligibilityCriteria":129,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":130,"targetDuration":4,"studyType":21,"phases":132,"briefSummary":133,"conditions":134,"keywords":136,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":151,"lastUpdatePostDateStruct":152,"startDateStruct":154,"completionDateStruct":156,"leadSponsor":158,"locationsCount":96},"100621869","effects-of-whole-fruit-on-blood-sugar-in-people-with-type-2-diabetes-100621869","NCT07376226","Effects of Whole Fruit on Blood Sugar in People With Type 2 Diabetes","Effects of Whole Fruit on Glycemic Control, Liver Fat, and Cardiovascular Disease Risk Factors in Adults With Type 2 Diabetes","FRUIT2","Inclusion Criteria:\n\n* Aged ≥18 years\n* Diagnosed with type 2 diabetes\n* HbA1c between 6.5-12.0%\n* Fasting C-peptide level ≥0.5 ng\u002Fml, indicating the patient does not have beta-cell failure, as measured at screening\n\nExclusion Criteria:\n\n* On insulin\n* Evidence of latent autoimmune diabetes (LADA) or maturity-onset diabetes of the young (MODY)\n* Estimated glomerular filtration rate (eGFR) \\\u003C45 ml\u002Fmin per 1.73 m²\n* Heart attack in the past 6 months or severe\u002Funstable heart failure\n* On weight loss medication, including GLP-1 receptor agonists (e.g., semaglutide, dulaglutide)\n* Change in the dosage of a chronic medication that may affect study endpoints within the past 3 months\n* Clinically significant laboratory abnormality (e.g., abnormal hemoglobin levels)\n* Significant gastrointestinal disease, major gastrointestinal surgery, or gallstones\n* Significant cardiovascular, renal, cardiac, liver, lung, adrenal, or nervous system disease that might compromise participant safety or data validity\n* Evidence of cancer (other than non-melanoma skin cancer) within the last 5 years\n* Lost or gained more than 5 lbs (or more than 2% of body weight if the patient weighs \\>250 lbs) of weight in the past 2 months\n* Pregnant, planning to become pregnant in the next 6 months, or breastfeeding\n* Major psychiatric condition that would affect the ability to participate in the study\n* Not able to eat the provided study meals (e.g., food allergies)\n* Behavioral factors or circumstances that may impede adherence to the dietary intervention\n* Not able to undergo the MRI scan (e.g., due to claustrophobia, implanted metal objects, or body girth ≥60 cm)",{"count":131,"type":20},25,[23],"This study will determine the effects of consuming whole fruit on blood sugar control, liver fat, and cardiovascular health in adults with type 2 diabetes who are not treated with insulin.",[135],"Type 2 Diabetes",[137,138,139,140,141,142,143,144,145,146,147,148,149,150],"type 2 diabetes","whole fruit","dietary intervention","glycemic control","liver fat","continuous glucose monitoring","blood sugar","nutrition","fruit","glucose","insulin","blood pressure","carbohydrates","high-carbohydrate diet","2026-01-30",{"date":153,"type":34},"2026-02-03",{"date":155,"type":20},"2026-04",{"date":157,"type":20},"2028-04",{"name":40,"class":41},{"id":160,"slug":161,"hasResults":11,"nctId":162,"briefTitle":163,"officialTitle":164,"acronym":4,"eligibilityCriteria":165,"healthyVolunteers":11,"sex":16,"minAge":166,"maxAge":167,"enrollmentInfo":168,"targetDuration":4,"studyType":21,"phases":169,"briefSummary":170,"conditions":171,"keywords":178,"overallStatus":87,"whyStopped":4,"lastUpdateSubmitDate":183,"lastUpdatePostDateStruct":184,"startDateStruct":186,"completionDateStruct":188,"leadSponsor":190,"locationsCount":96},"100591585","beat-the-heat-boston-100591585","NCT06982339","Beat the Heat Boston","Beat the Heat: Impacts of Heat on Health in Boston and Strategies to Address Them","Inclusion Criteria:\n\n* reside in Roxbury, Dorchester, East Boston or Mattapan MA\n* age 55-95 years old\n* speak English or Spanish\n* do not have air conditioning in the home\n* living with at least one of the following conditions: chronic CVD (hypertension, hyperlipidemia, diabetes, history of stroke or myocardial infarction, atrial fibrillation, or heart failure), chronic pulmonary disease (asthma, COPD\u002Femphysema, interstitial lung disease), chronic neurologic disease (stroke, Parkinson's disease, or other chronic neurologic conditions), chronic mental health conditions (including anxiety disorder, major depression, bipolar disorder), and\u002For history of hospitalization (defined as spending at least one night in the hospital) for any reason within the past three years.\n\nExclusion Criteria:\n\n\\- Lack a location in their home suitable for installation of the AC unit provided during the research study.","55 Years","95 Years",{"count":19,"type":20},[23],"The goal of this stepped wedge trial is to assess the practical effects of air conditioners on hot weather impacts among older adults. The main questions it aims to answer are:\n\nHow does the presence of an air conditioning unit affect heat stress, heat strain, mental health, and healthcare utilization among older adults who did not previously have access to air conditioning?\n\nHow, and in what conditioners, do older adults use air conditioning once it is installed in their home?\n\nResearchers will compare participants in arms with (A) and without (B) air conditioning units in the first summer season; this will allow them to assess the effect of air conditioners. In the second summer season, both arms will have air conditioning units, but those in the year two distribution arm (B) will receive an electricity subsidy, while those in the year one AC distribution arm (A) will not, allowing researchers to assess the effect of an electricity subsidy.\n\nParticipants will be randomized to receive an air conditioner and financial support for electricity costs in either the first summer season or the second summer season of the study.\n\n* Heat stress, heat strain, mental health, and healthcare utilization will be assessed via participant survey.\n* Air conditioner utilization will be assessed via continuous load monitoring devices.\n* Indoor air temperature will be assessed via continuous data loggers.",[172,173,174,175,176,177],"Hot Weather; Adverse Effect","Heat Effect","Heat Stress","Heat Stroke, Heat Exhaustion","Heat Exposure","Heat Strain",[179,180,181,182],"Cooling","Air conditioner","Heat related illness","stepped wedge","2026-01-21",{"date":185,"type":34},"2026-01-22",{"date":187,"type":34},"2025-05-19",{"date":189,"type":20},"2026-10-15",{"name":40,"class":41},{"id":192,"slug":193,"hasResults":11,"nctId":194,"briefTitle":195,"officialTitle":196,"acronym":197,"eligibilityCriteria":198,"healthyVolunteers":15,"sex":16,"minAge":4,"maxAge":199,"enrollmentInfo":200,"targetDuration":4,"studyType":21,"phases":202,"briefSummary":203,"conditions":204,"keywords":207,"overallStatus":87,"whyStopped":4,"lastUpdateSubmitDate":212,"lastUpdatePostDateStruct":213,"startDateStruct":214,"completionDateStruct":216,"leadSponsor":217,"locationsCount":218},"100574944","lift-up-randomized-controlled-trial-of-fortification-of-human-milk-100574944","NCT06765863","LIFT-UP: Randomized Controlled Trial of Fortification of Human Milk","Low Birthweight and Preterm Infant Feeding Trial and Supportive Care Package (LIFT-UP): Randomized Controlled Trial of In-facility Fortification of Human Milk in India","LIFT-UP RCT","Inclusion Criteria:\n\n* Very LBW (≤1.5kg)\\* or very preterm (≤32 weeks) infants admitted to NICU at study facility within 24 hours of birth for in-born infants and up to 48 hours for out-born\\*\\*\n* Mother and infant alive during screening\n* Mother age 18+ years\n* Lives within catchment areas of the facility\n* Mother intends to stay in catchment area of the study facility for at least 3 months\n* At randomization: Infant receiving at least 60 mL\u002Fkg\u002Fday of human milk\\*\\*\\*\n\nExclusion Criteria:\n\n* Lives outside the defined catchment area\n* Congenital abnormalities or acquired conditions that interfere with feeding or placement of nasogastric\u002Forogastric tube \\[cleft lip\u002Fpalate, toxoplasmosis, other agents, rubella, cytomegalovirus, and herpes (TORCH), Trisomy 21, congenital cardiac defect, neural tube defect, gastrointestinal tract anomalies, hydrocephalus, NEC\\]\n* Severe birth asphyxia\n* Critically ill (i.e. not on enteral feeds)\n* Unknown date of birth and unknown gestational age","48 Hours",{"count":201,"type":20},776,[23],"The goal of the LIFT-UP randomized controlled trial is to evaluate the efficacy of feeding routinely and fortified human milk using a standardized clinical protocol to very low birthweight (VLBW) or very preterm (VPT) infants in the NICU compared to not feeding routinely fortified human milk using the standardized clinical protocol.\n\nThe primary research question is: Will VLBW or VPT infants in the NICU who are fed fortified human milk using a standardized feeding protocol have better growth outcomes by facility discharge and at 3 months of age, less illness by discharge, and decreased mortality by discharge and at one month compared to those who are not routinely fed fortified human milk using the same feeding protocol?",[205,206],"Very Preterm Infant","Very Low Birthweight",[208,209,210,211],"very preterm","very low birthweight","fortification","human milk","2026-01-16",{"date":183,"type":34},{"date":215,"type":34},"2025-01-16",{"date":120,"type":20},{"name":40,"class":41},4,{"id":220,"slug":221,"hasResults":11,"nctId":222,"briefTitle":223,"officialTitle":224,"acronym":4,"eligibilityCriteria":225,"healthyVolunteers":11,"sex":16,"minAge":226,"maxAge":227,"enrollmentInfo":228,"targetDuration":4,"studyType":21,"phases":230,"briefSummary":232,"conditions":233,"keywords":4,"overallStatus":87,"whyStopped":4,"lastUpdateSubmitDate":235,"lastUpdatePostDateStruct":236,"startDateStruct":238,"completionDateStruct":240,"leadSponsor":242,"locationsCount":96},"100523925","phase-3-zinc-supplementation-for-young-infants-with-clinical-severe-infection-in-tanzania-100523925","NCT06102044","Zinc Supplementation for Young Infants With Clinical Severe Infection in Tanzania","Trial of Zinc Supplements for Young Infants With Clinical Severe Infection in Tanzania","Inclusion Criteria:\n\n* Young infants aged 0-59 days\n* Diagnosis of clinical severe infection (CSI)\n* Ability to feed enterally\n* Intend to stay in the study area for 90 days\n* Provided informed consent\n\nExclusion Criteria:\n\n* Prior use of zinc supplements during the current illness\n* Receipt of antibiotics for \\>24 hours before enrollment\n* Diarrhea at enrollment\n* Signs suggestive of serious illness\u002Fcondition that is not clinical severe infection\n* Previously enrolled in the trial\n* Enrolled in other research study","0 Days","59 Days",{"count":229,"type":20},3250,[231],"PHASE3","Bacterial infections among young infants, including sepsis, meningitis, and pneumonia, continue to cause a substantial number of deaths globally. Zinc supplementation in combination with standard antibiotic therapy may represent a new intervention to reduce mortality and improve treatment outcomes for young infants with clinical severe infection.\n\nThe Investigators will conduct a randomized, double-blind, placebo-controlled trial of zinc supplementation among young infants 0-59 days with severe clinical infection. The trial will enroll 3,250 Tanzanian infants hospitalized with clinical severe infection as defined by WHO Integrated Management of Childhood Illness (IMCI) guidelines. Enrolled infants will receive standard clinical management including antibiotics and will be randomized to receive either a 14-day course of twice-daily 5 mg elemental zinc (10 mg per day) or a matching placebo regimen.",[234],"Neonatal Infection","2025-12-05",{"date":237,"type":34},"2025-12-12",{"date":239,"type":34},"2024-12-27",{"date":241,"type":20},"2027-10-30",{"name":40,"class":41},{"id":244,"slug":245,"hasResults":11,"nctId":246,"briefTitle":247,"officialTitle":248,"acronym":249,"eligibilityCriteria":250,"healthyVolunteers":15,"sex":16,"minAge":50,"maxAge":251,"enrollmentInfo":252,"targetDuration":4,"studyType":21,"phases":254,"briefSummary":255,"conditions":256,"keywords":4,"overallStatus":87,"whyStopped":4,"lastUpdateSubmitDate":261,"lastUpdatePostDateStruct":262,"startDateStruct":264,"completionDateStruct":266,"leadSponsor":268,"locationsCount":96},"100513200","culturally-adapted-dietary-clinical-trial-in-pr-100513200","NCT05962372","Culturally Adapted Dietary Clinical Trial in PR","Culturally Adapted Dietary Clinical Trial in PR: Puerto Rico Evaluation of a Culturally Informed Sustainable Intervention for Optimal Nutrition (PRECISION)","PRECISION","Inclusion Criteria:\n\n1. Age 30-65y old at the time of enrollment\n2. Non-institutionalized\n3. Living in PR at the time of recruitment and for at least the previous year and not planning to move from the island within the next 3 years\n4. Able to answer questions without assistance\n5. Having a cellphone with the capacity to receive text messages and be willing to receive daily text messages from the study on the designated cellphone number\n6. Having at least one of the following:\n\n   1. elevated BMI\n   2. elevated waist circumference\n   3. self-reported physician-diagnosed hypertension or use of hypertension medication or measured high blood pressure at the baseline visit\n   4. self-reported physician-diagnosed pre-diabetes or measured pre-diabetes at the baseline visit\n   5. self-reported physician-diagnosed dyslipidemia or use of lipid-lowering agents or laboratory values confirming dyslipidemia\n\nExclusion Criteria:\n\n1. Under 30 or over 65 years of age (on the day of the interview).\n2. Currently not living in Puerto Rico or not lived on the island for at least 1 year or planning to move within 3 years\n3. Institutionalized\n4. Not able to answer questions without assistance\n5. Not having at least 1 of the five listed metabolic criteria\n6. Self-reported physician-diagnosed type 1 or type 2 diabetes or use of diabetes medication (including insulin) or diabetes-diagnosis values confirmed by laboratory\n7. Self-reported pregnancy\n8. Gastrointestinal or chronic condition that would impact eating behaviors or nutritional status\n9. Intolerance or allergies to legumes (i.e.: beans and nuts), vegetable oils (i.e.: corn, olive, canola), or fresh produce\n10. Living with another person participating in the study\n11. Participating in another research study that conflicts with PRECISION","65 Years",{"count":253,"type":20},250,[23],"This project will determine whether a diet culturally adapted to adults in Puerto Rico can effectively decrease cardiometabolic risk factors. This will help define a culturally-appropriate, feasible, and sustainable diet intervention aimed at reducing cardiovascular, type 2 diabetes, and obesity outcomes.",[257,60,59,61,258,259,260],"Diabetes Mellitus, Type 2","High Triglycerides","High Blood Glucose","Abdominal Obesity","2025-07-29",{"date":263,"type":34},"2025-07-31",{"date":265,"type":34},"2024-05-02",{"date":267,"type":20},"2029-05-02",{"name":40,"class":41},""]