[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Hasselt University\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":651},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,23,0,[8,46,79,116,148,175,198,228,258,285,311,339,367,386,417,445,469,497,524,554,578,601,624],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":28,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100637816","gait-adaptability-in-persons-with-ms-having-mild-disability-100637816",false,"NCT07580820","Gait Adaptability in Persons With MS Having Mild Disability","Multidimensional Assessment of Gait Adaptability in Persons Multiple Sclerosis With no to Mild Disability","Inclusion Criteria:\n\n* Age between 18-65 years,\n* confirmed diagnosis of definite MS,\n* relapse free at least 30 days,\n* Expanded Disability Status Scale (EDSS) score between 0 and 3.5\n\nExclusion Criteria:\n\n* Diagnosed with neurological disease other than MS\n* cognitive decline that renders the patient incapable of performing tests and questionnaires.\n* Other neurological, orthopedic, or visual impairments affecting gait",true,"ALL","18 Years","65 Years",{"count":21,"type":22},32,"ESTIMATED","OBSERVATIONAL","Multiple sclerosis (MS) is a chronic inflammatory and neurodegenerative disease of the central nervous system that frequently leads to walking impairment, balance deficits, fatigue, cognitive difficulties, and an increased risk of falls. Importantly, these problems can already be present in the early stages of the disease and may not be adequately captured by standard clinical walking tests, which primarily assess speed or distance. Such tests are often insufficient to reflect the complexity of real-life walking, which requires continuous adaptation to environmental challenges, and attention to internal and external stimuli.\n\nGait adaptability, the ability to modify walking patterns in response to changing and unpredictable demands such as obstacles or sudden perturbations, is critical for safe mobility and fall prevention. Both proactive (anticipatory) and reactive (feedback-driven) gait adaptations are essential for maintaining balance and functional independence. However, gait adaptability and its underlying neural mechanisms remain insufficiently understood in people with MS.\n\nThis study aims to provide a comprehensive assessment of gait adaptability in people with MS by evaluating both proactive and reactive gait adaptations using objective gait measurements and cortical activity recordings. The findings may contribute to the development of more sensitive outcome measures and inform targeted rehabilitation strategies that better reflect real-life mobility demands.\n\nPrimary aims:\n\n• To investigate the behavioral measures and neural correlates of reactive and proactive gait adaptability in pwMS compared to HC\n\nSecondary aims:\n\n* To investigate factors related to gait adaptability\n* To investigate changes in gait adaptability during prolonged walking conditions",[26,27],"Multiple Sclerosis","Healthy Adults",[29,30,31,32],"multiple sclerosis","gait","gait adaptability","balance","RECRUITING","2026-05-05",{"date":36,"type":37},"2026-05-12","ACTUAL",{"date":39,"type":37},"2025-12-05",{"date":41,"type":22},"2026-12-20",{"name":43,"class":44},"Hasselt University","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":4,"eligibilityCriteria":52,"healthyVolunteers":16,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":53,"targetDuration":55,"studyType":23,"phases":4,"briefSummary":56,"conditions":57,"keywords":62,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":78},"100639140","physiotherapy-practice-in-flemish-nursing-homes-100639140","NCT07576751","Physiotherapy Practice in Flemish Nursing Homes","Physiotherapy in Flemish Nursing Homes: Insights Into Practice, Barriers, and Facilitators","Inclusion Criteria:\n\n* None beyond being a licensed physiotherapist working in a Flemish nursing home and willing to participate.\n\nExclusion Criteria:\n\n* None",{"count":54,"type":22},40,"2 Weeks","The goal of this observational study is to evaluate the extent to which physiotherapy sessions in Flemish nursing homes adhere to the IAGG-GARN guidelines and to explore factors influencing clinical practice among physiotherapists.\n\nThe study targets multiple nursing homes across Flanders, with 3 to 5 centers in each of the provinces of Limburg, Antwerp, and Flemish Brabant. This selection ensures variation in geographic location and organizational context. The participants in this study are physiotherapists working in the participating nursing homes.\n\nThe main questions it aims to answer are:\n\n* To what extent do the physiotherapy sessions align with the IAGG-GARN guidelines?\n* Are there differences in physiotherapy session content and volume according to physiotherapist characteristics and resident characteristics?\n* What barriers and facilitators do physiotherapists experience when implementing guideline-based practice in Flemish nursing homes?\n\nResearchers will observe physiotherapy sessions delivered as part of routine care and document session content and duration using structured observation diaries. Participating physiotherapists will also take part in focus groups discussing experiences with guideline implementation, barriers, facilitators, and clinical decision-making.",[58,59,60,61],"Guideline Implementation","Physiotherapy","Nursing Homes","Focus Group",[63,64,65,66,67,68,69],"Physical therapy","Older adults","Geriatrics","Long-term care","Guideline implementation","Focus groups","Clinical practice","2026-05-04",{"date":72,"type":37},"2026-05-08",{"date":74,"type":37},"2026-03-23",{"date":76,"type":22},"2028-12-01",{"name":43,"class":44},3,{"id":80,"slug":81,"hasResults":11,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":85,"eligibilityCriteria":86,"healthyVolunteers":16,"sex":17,"minAge":19,"maxAge":87,"enrollmentInfo":88,"targetDuration":4,"studyType":90,"phases":91,"briefSummary":93,"conditions":94,"keywords":101,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":108,"lastUpdatePostDateStruct":109,"startDateStruct":111,"completionDateStruct":113,"leadSponsor":115,"locationsCount":45},"100633108","acute-power-training-effects-in-older-adults-100633108","NCT07522398","Acute Power Training Effects in Older Adults","Acute Neuromuscular and Physiological Responses to Different Velocity Loss Thresholds During Power Training in Older Adults","APTE-OA","Inclusion criteria:\n\nParticipants must:\n\n* Be 65 to 85 years old.\n* Be able to live independently and perform everyday activities without help.\n* Not have regularly done resistance or strength training in the past year.\n* Be able to understand study instructions and communicate in the study language.\n* Have a recent statement from their treating physician confirming that their heart and blood vessels are healthy enough to safely take part in this study.\n\nExclusion criteria\n\nParticipants will not be eligible if they have any of the following:\n\n* Unstable heart disease, neurological disease, acute infection, or fever.\n* Use of non-steroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen, in the 5 days before the study.\n* Use of whey protein, casein, or amino acid supplements in the month before the study.\n* Acute or chronic injuries to the legs or lower body muscles.\n* Any injury or condition that prevents safe leg extension exercises.\n* Recent lower-limb joint replacement (less than 6 months ago).\n* Dependence on walking aids.\n* Current participation in another interventional trial.","85 Years",{"count":89,"type":22},42,"INTERVENTIONAL",[92],"NA","The goal of this clinical trial is to learn how older adults respond to power training when the level of fatigue during exercise is different. Power training means performing fast movements with moderate loads to improve strength, power and mobility.\n\nThe main questions the study aims to answer are:\n\n* How does the level of fatigue during power training acutely affect strength, movement, and muscle function?\n* How does it affect recovery, muscle soreness, and how hard the exercise feels?\n\nResearchers will compare three power-training sessions with different fatigue levels to see which approach may be safest and most effective for older adults.\n\nParticipants will be healthy older adults aged 65 to 85 years. Each participant will complete three supervised exercise sessions on a leg press machine. The sessions will take place about one week apart.\n\nDuring the study, participants will:\n\n* Perform power training on a pneumatic leg press machine\n* Complete strength and mobility tests before and after exercise\n* Provide small blood samples to measure body responses to exercise\n* Rate how hard the exercise feels\n* Report muscle soreness for up to two days after exercise\n\nThe results may help researchers design safer and more effective power-training programs to improve strength, mobility, and recovery in older adults.",[95,96,97,98,99,100],"Muscle Power","Functional Performance","Older Adults (65 Years and Older)","Neuromuscular Function","Physiological Responses","Healthy Older Adults",[102,103,104,95,105,106,98,96,99,107],"Power Training","Older Adults","Aging","Velocity Loss","Resistance Training","Exercise Fatigue","2026-04-03",{"date":110,"type":37},"2026-04-13",{"date":112,"type":22},"2026-04-20",{"date":114,"type":22},"2027-01",{"name":43,"class":44},{"id":117,"slug":118,"hasResults":11,"nctId":119,"briefTitle":120,"officialTitle":121,"acronym":122,"eligibilityCriteria":123,"healthyVolunteers":11,"sex":17,"minAge":124,"maxAge":125,"enrollmentInfo":126,"targetDuration":4,"studyType":90,"phases":128,"briefSummary":129,"conditions":130,"keywords":132,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":140,"lastUpdatePostDateStruct":141,"startDateStruct":143,"completionDateStruct":145,"leadSponsor":147,"locationsCount":45},"100572536","the-effect-of-exercise-on-the-brain-in-type-2-diabetes-100572536","NCT06734546","The Effect of Exercise on the Brain in Type 2 Diabetes","The Effect of Exercise of High vs. Moderate Intensity on the Brain in Type 2 Diabetes","SAINT","Inclusion Criteria:\n\n* type 2 diabetes\n* no insulin therapy\n* 30-75 years old\n* physically inactive\n\nExclusion Criteria:\n\n* MRI contraindications\n* psychological disorders\n* exogenous insulin therapy\n* history of coma, transient ischemic attack, head trauma, brain tumor, stroke, epilepsy, and other central nervous system diseases that could cause dementia or presence of dementia before T2DM\n* suffering from any disease with significant impact on exercise intervention participation such as: chronic heart disease (e.g. valve insufficiency ≥ grade 2) or significant arrhythmias, cardiac events less than one year ago (myocardial infarction, coronary artery bypass graft, percutaneous coronary intervention), clinical heart failure (oedema, shortness of breath), percutaneous coronary intervention less than one year ago, chronic obstructive pulmonary disease (COPD), cerebrovascular or peripheral vascular disease\n* severe hypertension (\\>160\u002F110 mmHg)\n* ongoing cancer, severe neuropathy (limiting exercise participation)\n* renal disease (GRF \\\u003C45 ml\u002Fmin\u002F1,73 m2)\n* inability to regularly participate in the exercise intervention\n* pregnancy\n* breastfeeding","30 Years","75 Years",{"count":127,"type":22},75,[92],"The goal of this clinical trial is to learn if exercise training of high or moderate intensity is most optimal to improve brain health and prevent neurodegeneration in type 2 diabetes patients. The main question it aims to answer is:\n\nWhat is the effect of exercise training of high vs. moderate intensity on brain metabolism, brain perfusion, and cognition in type 2 diabetes?\n\nResearchers will compare the exercise training groups to a control group without exercise training to determine the effect of exercise training on the brain in type 2 diabetes.\n\nParticipants will exercise for 6 months, 3 times per week. Before and after these 6 months, they will undergo:\n\n* a brain MRI scan\n* cognitive tests\n* blood sampling",[131],"Type 2 Diabetes",[133,134,135,136,137,138,139],"type 2 diabetes","exercise intervention","brain","cognition","neurometabolism","dementia","cerebral perfusion","2026-03-30",{"date":142,"type":37},"2026-03-31",{"date":144,"type":37},"2024-11-08",{"date":146,"type":22},"2027-08",{"name":43,"class":44},{"id":149,"slug":150,"hasResults":11,"nctId":151,"briefTitle":152,"officialTitle":153,"acronym":4,"eligibilityCriteria":154,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":155,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":157,"conditions":158,"keywords":160,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":166,"lastUpdatePostDateStruct":167,"startDateStruct":169,"completionDateStruct":171,"leadSponsor":173,"locationsCount":174},"100631797","measurement-properties-of-the-walking-adaptability-ladder-test-and-foot-tap-test-in-multiple-sclerosis-100631797","NCT07505355","Measurement Properties of the Walking Adaptability Ladder Test and Foot Tap Test in Multiple Sclerosis","Measurement Properties of the Walking Adaptability Ladder Test and Foot Tap Test in People With Multiple Sclerosis With Mild Disability","Inclusion Criteria:\n\n* confirmed diagnosis of definite MS,\n* relapse free at least 30 days,\n* Expanded Disability Status Scale (EDSS) score between 0 and 3.5\n\nExclusion Criteria:\n\n* diagnosed with neurological disease other than MS\n* cognitive decline that renders the patient incapable of performing tests and questionnaires.\n* other neurological, orthopedic, or visual impairments affecting gait",{"count":156,"type":22},100,"Walking and motor control impairments are among the most common manifestations experienced by people with multiple sclerosis (pwMS) and may already be present in individuals with mild disability. Subtle changes in walking performance can reflect early disease progression, highlighting the need for sensitive clinical outcome measures that capture complex, real-world mobility. Commonly used assessments primarily quantify time or distance and may lack sensitivity to detect early or subtle functional changes in daily-life walking. Successful everyday mobility requires gait adaptability, defined as the ability to continuously adjust walking patterns in response to environmental or task-related challenges, including the processing of external perturbations and internal factors such as fatigue, balance confidence, and fear of falling. Despite its clinical relevance, gait adaptability is not specifically addressed by currently validated clinical tests in pwMS. The Walking Adaptability Ladder Test (WALT), which challenges the interaction between step length, cadence, and walking speed through continuous adjustments, and the Foot Tap Test (FTT), which assesses lower limb motor control and rhythmic coordination, have demonstrated promising measurement properties in other populations but have not yet been evaluated in pwMS. The primary aim of this study is to examine the test-retest reliability and construct validity of the WALT and FTT in pwMS with mild disability. Secondary aims include evaluating the measurement properties of the Balance Recovery Scale and the Gait-Specific Attention Scale in pwMS with mild disability, identifying inertial measurement unit-derived metrics that best discriminate pwMS with low disability from healthy controls, and exploring whether relationships between clinical motor test outcomes and self-reported measures provide complementary insights into subtle gait impairments.",[26,159],"Healthy Controls Group - Age and Sex-matched",[29,161,162,163,164,165],"walking","tapping","motor function","walking adaptability","falls","2026-03-26",{"date":168,"type":37},"2026-04-01",{"date":170,"type":37},"2025-11-10",{"date":172,"type":22},"2026-12-01",{"name":43,"class":44},4,{"id":176,"slug":177,"hasResults":11,"nctId":178,"briefTitle":179,"officialTitle":179,"acronym":4,"eligibilityCriteria":180,"healthyVolunteers":11,"sex":17,"minAge":181,"maxAge":18,"enrollmentInfo":182,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":183,"conditions":184,"keywords":186,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":190,"lastUpdatePostDateStruct":191,"startDateStruct":193,"completionDateStruct":195,"leadSponsor":197,"locationsCount":45},"100630339","task-specific-maximal-strength-and-motor-fatigability-during-daily-activities-of-the-arms-and-hands-in-typically-developing-children-100630339","NCT07486388","Task-specific Maximal Strength and Motor Fatigability During Daily Activities of the Arms and Hands in Typically Developing Children","Inclusion Criteria:\n\n* Age between 7 and 18 years\n* Sufficient understanding of the Dutch language to comprehend and perform the test procedures (also applicable to the parents\u002Flegal guardians)\n\nExclusion Criteria:\n\n* Upper limb movement problems within the past 6 months\n* Trauma to the upper limb within the past 6 months","7 Years",{"count":127,"type":22},"The aim of this study is to measure task-specific maximal strength and motor fatigability during functional daily activities involving the upper limbs in typically developing children. The focus is on determining the test-retest reliability of these measurements. In addition, the results are compared with existing data from children with cerebral palsy (CP). Through this comparison, we aim to gain insight into the motor limitations experienced by children with CP when performing everyday tasks.",[185],"Typically Developing Children",[187,188,189],"Motor fatigability","Strength","Upper limbs","2026-03-17",{"date":192,"type":37},"2026-03-20",{"date":194,"type":37},"2025-11-05",{"date":196,"type":22},"2026-07",{"name":43,"class":44},{"id":199,"slug":200,"hasResults":11,"nctId":201,"briefTitle":202,"officialTitle":203,"acronym":204,"eligibilityCriteria":205,"healthyVolunteers":16,"sex":206,"minAge":18,"maxAge":207,"enrollmentInfo":208,"targetDuration":4,"studyType":90,"phases":210,"briefSummary":211,"conditions":212,"keywords":215,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":220,"lastUpdatePostDateStruct":221,"startDateStruct":223,"completionDateStruct":225,"leadSponsor":227,"locationsCount":45},"100379910","the-role-of-proprioceptive-deficits-psychosocial-factors-and-inflammation-in-pregnancy-related-pelvic-girdle-pain-100379910","NCT04226716","The Role of Proprioceptive Deficits, Psychosocial Factors and Inflammation in Pregnancy-related Pelvic Girdle Pain","The Role of Lumbar Proprioceptive Deficits, Psychosocial Factors and Inflammation in Pregnancy-related Pelvic Girdle Pain: a Follow-up Study in Multiparous Pregnant Women","PROFit","Inclusion Criteria Multiparous Women:\n\n* Singleton pregnancy\n* Pregnant of second child or more than second child\n* No current PPGP or did not have PPGP during current pregnancy\n* Willing to provide written informed consent\n\nExclusion Criteria Multiparous Women:\n\n* Pregnant for more than 16 weeks\n* Having current PPGP or having had PPGP during the current pregnancy\n* History of surgery\u002Fmajor trauma to spine or pelvis\n* Surgery\u002Fphysical trauma to the lower limbs more than two years ago and currently still experiencing symptoms such as pain, instability, or stiffness\n* Surgery\u002Fphysical trauma to the lower limbs less than two years ago\n* Specific balance or vestibular disorders\n* A medical diagnosis of a rheumatic condition or being under treatment for such a condition by a rheumatologist\n* Neurological abnormalities (e.g., peripheral neuropathy)\n* Uncorrected visual problems\n* Acute ankle problems\n* Being on absolute or relative bed rest due to pregnancy-related complications\n* Having (had) a formal diagnosis of a psychiatric disorder\n* Non-Dutch speaking\n\nInclusion Criteria Nulliparous Women:\n\n* Age- and BMI- matched to pregnant participants\n* Nulliparous\n* Willing to provide written informed consent\n\nExclusion Criteria Nulliparous Women:\n\n* Having low back or pelvic girdle pain at the time of inclusion or in the six months leading up to inclusion\n* History of chronic low back or pelvic girdle pain\n* History of surgery\u002Fmajor trauma to spine, pelvis and\u002For lower limbs,\n* Specific balance or vestibular disorders\n* Spinal deformities\n* Rheumatic disease\n* Neurological abnormalities\n* Acute ankle problems\n* (A history of) psychiatric disorders\n* Uncorrected visual problems\n* Non-Dutch speaking","FEMALE","40 Years",{"count":209,"type":22},192,[92],"A large proportion of pregnant women develop pregnancy-related low back and\u002For pelvic girdle pain (PPGP), which often does not recover spontaneously postpartum. As a result, 10% of women with PPGP are thus crucial. However, the underlying mechanisms of PPGP are still poorly understood. The main objective of this study is to investigate whether lumbar proprioceptive deficits, a disturbed body perception at the lumbar spine, psychosocial factors (incl. pain-related fear of movement, depression, anxiety and stress) and increased serum concentrations of specific inflammatory mediators are associated with (1) a reduced postural control and (2) the development and\u002For persistence of PPGP in multiparous women during the first and third trimester of pregnancy, and six weeks and six months postpartum.",[213,214],"Pelvic Girdle Pain","Low Back Pain",[216,217,218,219],"Postural control","Body perception","Psychosocial factors","Inflammation","2026-02-27",{"date":222,"type":37},"2026-03-03",{"date":224,"type":37},"2020-06-01",{"date":226,"type":22},"2028-09-30",{"name":43,"class":44},{"id":229,"slug":230,"hasResults":11,"nctId":231,"briefTitle":232,"officialTitle":233,"acronym":234,"eligibilityCriteria":235,"healthyVolunteers":16,"sex":17,"minAge":207,"maxAge":236,"enrollmentInfo":237,"targetDuration":4,"studyType":90,"phases":239,"briefSummary":240,"conditions":241,"keywords":243,"overallStatus":249,"whyStopped":4,"lastUpdateSubmitDate":250,"lastUpdatePostDateStruct":251,"startDateStruct":253,"completionDateStruct":255,"leadSponsor":257,"locationsCount":45},"100625166","sedentary-behaviour-physical-activity-patterns-and-cardiometabolic-health-100625166","NCT07419100","Sedentary Behaviour, Physical Activity Patterns, and Cardiometabolic Health","From Sitting to Moving: How Physical Activity Patterns Can Reduce Sedentary Behaviour and Support Cardiometabolic Health","SPARC","Inclusion Criteria:\n\n* Adults aged 40-70 years\n* Sedentary (\\>9 hours per day)\n* \\\u003C 3 exercise sessions per week\n\nExclusion Criteria:\n\n* Pregnancy or intend to become pregnant\n* Any known contra-indications for physical activity\n* \\>14 alcohol consumptions per week for women and \\>20 alcohol consumptions per week for men\n* Involved in a weight reduction program with an energy restriction diet during the study period\n* No consistent body weight over the past month\n* Diagnosed with any known cardiometabolic health-related disease","70 Years",{"count":238,"type":22},48,[92],"According to the World Health Organization (WHO), chronic diseases are a major global public health concern and the leading cause of mortality worldwide. In the absence of evidence-based actions, the global annual deaths from chronic diseases are projected to rise to 55 million deaths in 2030, accompanied by a substantial increase in socio-economic costs. In this context, the WHO identifies type 2 diabetes mellitus (T2DM) and cardiovascular diseases (CVD) as key chronic conditions of concern related to cardiometabolic health.\n\nBoth sedentary behaviour (SB) and physical inactivity have been recognised as interdependent risk factors for the development of T2DM and CVD. SB refers to any waking behaviour, characterised by a low energy expenditure, while being in a sitting or reclining posture, whereas physical inactivity denotes insufficient levels (\\\u003C150 min per week,) of moderate-to-vigorous physical activity (MVPA). Studies using objective measures have demonstrated that on average Western adults spend 8-12h in SB per day, of which the majority is spent in prolonged sedentary bouts (lasting ≥30 min). In addition, up to 30% of adults worldwide are physically inactive, with higher levels of inactivity in high-income countries. Within this context, it has become evident that excessive prolonged SB, often in combination with physical inactivity, negatively impacts cardiometabolic health, contributing to insulin resistance, increased adiposity, poor lipid profiles and endothelial dysfunction. Given their detrimental effects on T2DM and CVD, strategies aimed at reducing SB and promoting physical activity (PA) warrant further investigation.\n\nReducing and regularly interrupting SB, even with low-intensity PA, alongside sufficient MVPA, is crucial for maintaining a healthy cardiometabolic profile. Reflecting this, the WHO guidelines advise individuals to engage in 150-300 minutes of moderate-intensity physical activity, 75-150 minutes of vigorous-intensity physical activity, or an equivalent combination each week. Notably, the 2020 WHO guidelines also included recommendations on SB for the first time, emphasizing the importance of limiting sedentary time. The WHO states that replacing SB with physical activity of any intensity can yield health benefits. However, these recommendations remain non-prescriptive and somewhat vague, primarily due to a lack of robust scientific evidence on the optimal frequency, intensity, and duration of PA needed to interrupt sedentary time. The absence of specific guidelines on prolonged SB reflects this evidence gap. To support policy development, well-designed randomised controlled trials are needed to evaluate effective and practical strategies for reducing sedentary time.\n\nSo far, the short term cardiometabolic health effects of SB interruptions have been investigated by our research group, laboratory studies of collaborators and other international researchers, demonstrating that; 1) more frequent SB interruptions especially affect glucose metabolism and insulin sensitivity; 2) higher intensity interruptions are associated with cardioprotective adaptations and; 3) longer durations of SB interruptions positively affect lipid metabolism. However, because under real-world conditions frequency, intensity and duration of SB interruptions usually interact, their combined effects on cardiometabolic health need further investigation. Many studies already compared the isolated effects of different SB interruption patterns with respect to frequency, duration and intensity on cardiometabolic health. However, the combined effects of these different approaches matched for energy expenditure are not clear yet. We therefore perform a balanced cross-over study in which the efficacy of distinct activity patterns on cardiometabolic health insulin sensitivity and vascular function) will be compared to a sedentary control condition.",[242],"Healthy Adult Participants",[244,245,246,247,248],"Physical Activity","Intensity","Frequency","Duration","Cardiometabolic health","NOT_YET_RECRUITING","2026-02-10",{"date":252,"type":37},"2026-02-18",{"date":254,"type":22},"2026-03-01",{"date":256,"type":22},"2028-06-01",{"name":43,"class":44},{"id":259,"slug":260,"hasResults":11,"nctId":261,"briefTitle":262,"officialTitle":263,"acronym":204,"eligibilityCriteria":264,"healthyVolunteers":11,"sex":206,"minAge":18,"maxAge":207,"enrollmentInfo":265,"targetDuration":4,"studyType":90,"phases":267,"briefSummary":268,"conditions":269,"keywords":271,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":276,"lastUpdatePostDateStruct":277,"startDateStruct":279,"completionDateStruct":281,"leadSponsor":283,"locationsCount":284},"100576485","proprioceptive-fear-related-and-inflammatory-factors-in-the-persistence-of-pregnancy-related-lumbopelvic-pain-100576485","NCT06785909","Proprioceptive, Fear-related and Inflammatory Factors in the Persistence of Pregnancy-related Lumbopelvic Pain.","The Role of Proprioceptive, Fear-related and Inflammatory Factors in the Persistence of Pregnancy-related Lumbopelvic Pain in Pregnant Women.","Inclusion Criteria:\n\n* Informed consent to participate\n* 18-40 years old\n* Pregnant\n* Singleton pregnancy (confirmed through ultrasound)\n* No current PLPP\n* Dutch- or English-speaking\n\nExclusion Criteria:\n\n* Pregnant for more than 16 weeks\n* Currently experiencing PLPP, or having had PLPP during the index pregnancy\n* History of surgery or major trauma to the spine or pelvis, major trauma or surgery to the lower limbs more than 2 years ago with current residual symptoms (e.g., pain, instability, stiffness), major trauma or surgery to the lower limbs less than 2 years ago\n* Specific vestibular or balance disorders\n* Use of medication that could affect balance (e.g., ototoxic or centrally-acting drugs)\n* Having a medical diagnosis for, being treated by a rheumatologist for, or taking medication for a rheumatic condition\n* (History of) a neurological disorder (e.g., neuropathy)\n* Problems with vision that are not corrected by glasses, contact lenses or surgical eye correction\n* Recent history of ankle problem (e.g., ankle sprain less than 3 weeks ago)\n* Being on absolute\u002Frelative bed rest due to pregnancy complications\n* (History of) inflammatory (e.g., gout, endometriosis), (auto)immune (e.g., lupus, ankylosis spondylitis, rheumatoid arthritis, psoriasis, Crohn's disease, Graves' disease, Hashimoto's thyroiditis, colitis ulcerosa, multiple sclerosis, etc.), hypothyroidism, or cancer.\n* Having (had) a formal diagnosis of a psychiatric disorder (e.g., psychotic disorder).",{"count":266,"type":22},211,[92],"Pregnancy-related lumbopelvic pain (PLPP) affects 50-90% of pregnant women and is often dismissed as a normal part of pregnancy. However, the long-term consequences can be dramatic. Up to 21% of women with PLPP still have pain three years postpartum, and 10% experience disability, poorer quality of life, and lower ability to work 11 years after delivery. Because the multifactorial etiology of PLPP is unclear, prevention and treatment fall short. Previous studies on the causes of PLPP focused on impairments in motor output but ignored that impairments in sensory input (e.g., proprioception, the primary expertise of our research group) often precede motor output problems. Moreover, though psychological factors such as fear (of movement) are known to affect PLPP, their predictive role in PLPP remains understudied. Finally, the role of systemic inflammation in PLPP has yet to be examined, despite recent studies demonstrating its role in the chronification of lumbopelvic pain in the general population.\n\nThis prospective cohort study aims to identify new modifiable predictors for the onset of PLPP during pregnancy and its persistence postpartum. The investigators will compare sensory (proprioception, body perception), fear-related, and inflammatory factors between women with and without PLPP and determine their predictive role in the onset and persistence of PLPP. The results will increase our understanding of the multifactorial etiology of PLPP and help optimize prevention and treatment.",[214,270,213],"Lumbopelvic Pain",[272,273,274,275],"postural control","body perception","psychological factors","inflammation","2025-11-26",{"date":278,"type":37},"2025-12-02",{"date":280,"type":37},"2025-03-03",{"date":282,"type":22},"2028-12-31",{"name":43,"class":44},2,{"id":286,"slug":287,"hasResults":11,"nctId":288,"briefTitle":289,"officialTitle":290,"acronym":4,"eligibilityCriteria":291,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":236,"enrollmentInfo":292,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":294,"conditions":295,"keywords":296,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":303,"lastUpdatePostDateStruct":304,"startDateStruct":306,"completionDateStruct":308,"leadSponsor":310,"locationsCount":78},"100606456","accuracy-of-motor-performance-perception-in-multiple-sclerosis-100606456","NCT07175792","Accuracy of Motor Performance Perception in Multiple Sclerosis","Assessment of Perceptive Accuracy for Motor Performance in Persons With Multiple Sclerosis","Inclusion Criteria:\n\n* age between 18 and 70 years old\n* ability to walk for 6 minutes without rest and without the need of a walking aid\n* ability to repeatedly perform the sit to stand transitions on a standard chair (43cm seat height) without hand support\n\nFor People with Multiple Sclerosis group\n\n* a diagnosis of MS (2017 revisions of the McDonalds criteria)\n* no disease relapses \\>1 month preceding the start of the study\n\nExclusion Criteria:\n\n* cognitive impairment hindering understanding of study instructions\n* ongoing or suspected pregnancy\n* musculoskeletal disorders in the lower limbs\n* cardiovascular red flags for exercise (screened with Physical Activity Readines Questionnaire)\n* other diagnosis for neurological or metabolic disease limiting the full execution of the tests",{"count":293,"type":22},88,"The aim of this study is to characterize perceptive abilities in PwMS compared to controls when performing prolonged functional tasks such as walking and repeated standing from a seated position.\n\nThis study proposes primary and secondary research questions which will be tested in the context of two different newly designed experimental tasks and will be performed in maximum three days.\n\nThe self-reported beliefs over perceptive abilities and the performance in the experimental perceptive tasks will be compared between persons with multiple sclerosis and an equally sized group of age and gender matched healthy controls. The results of this study may uncover specific deficits in the MS population and will help in defining subgroups of patients with weaker perceptive capacities to gauge their motor performance and therefore in need for tailored interventions additional to the standard practice.",[26],[297,298,299,26,300,301,302],"Motor Performance","Task-specific","Perception","Walking","Sit-to-stand","Inteoception","2025-11-18",{"date":305,"type":37},"2025-11-19",{"date":307,"type":37},"2024-12-09",{"date":309,"type":22},"2025-12-09",{"name":43,"class":44},{"id":312,"slug":313,"hasResults":11,"nctId":314,"briefTitle":315,"officialTitle":316,"acronym":4,"eligibilityCriteria":317,"healthyVolunteers":16,"sex":17,"minAge":181,"maxAge":318,"enrollmentInfo":319,"targetDuration":4,"studyType":90,"phases":321,"briefSummary":322,"conditions":323,"keywords":326,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":332,"lastUpdatePostDateStruct":333,"startDateStruct":335,"completionDateStruct":337,"leadSponsor":338,"locationsCount":45},"100577730","movement-strategies-during-balance-tasks-in-children-with-and-without-developmental-coordination-disorder-100577730","NCT06802094","Movement Strategies During Balance Tasks in Children With and Without Developmental Coordination Disorder","Case-Control Research of the Movement Strategies Used During Balance Tasks in Children With and Without Developmental Coordination Disorder","Inclusion Criteria:\n\nFor children with DCD\n\n* Children with the clinical diagnosis of Developmental Coordination Disorder (DCD) based on criteria of the DSM-5 (APA, 2013), diagnosed by a pediatrician.\n* Children who have no formal diagnosis are evaluated by the research team using the diagnostic criteria as outlined in the inclusion criteria, these children will be included as \"suspected of having DCD\"\n* Balance problems need to be present and objectified with the Balance Evaluation Systems Test for Children, second edition (Kids-BESTest-2). (total score below 80%)\n\nFor children without DCD\n\n* Total score at or below the 25th percentile on the Movement Assessment Battery for children, second edition\n* Normal postural control, objectified by the Kids-BESTest-2 (score at or above 80%)\n* Match with children with DCD based on their sex, age and potential comorbidities.\n\nExclusion Criteria:\n\nPresence of:\n\n* Intellectual problems\n* Visual problems\n* Vestibular problems\n* Neurological conditions\n* Not able to follow instructions due to behavioral problems\n* Refuse to participate","12 Years",{"count":320,"type":22},50,[92],"The main objective of the study is to gain insights in how children learn a balance task and whether there is a difference between children with and without Developmental Coordination Disorder. Furthermore, the investigators are interested in the brain activity of these children while learning this new balance task.",[324,325],"Development Coordination Disorder","Typical Developed Children",[216,327,328,329,330,331],"Movement strategies","Brain activity","Postural balance [Mesh]","Pediatrics [Mesh]","Motor Skills Disorders [Mesh]","2025-09-15",{"date":334,"type":37},"2025-09-16",{"date":336,"type":37},"2025-08-18",{"date":146,"type":22},{"name":43,"class":44},{"id":340,"slug":341,"hasResults":11,"nctId":342,"briefTitle":343,"officialTitle":343,"acronym":344,"eligibilityCriteria":345,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":346,"targetDuration":348,"studyType":23,"phases":4,"briefSummary":349,"conditions":350,"keywords":353,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":359,"lastUpdatePostDateStruct":360,"startDateStruct":362,"completionDateStruct":364,"leadSponsor":366,"locationsCount":284},"100576064","structural-characteristics-of-trunk-and-limb-muscles-in-cachectic-colorectal-cancer-patients-100576064","NCT06780423","Structural Characteristics of Trunk and Limb Muscles in Cachectic Colorectal Cancer Patients","CTLm-CCP","Cachectic colorectal cancer patients.\n\nInclusion criteria:\n\n* minimum age of 18 years old\n* unwanted weight loss \\> 5% in the last 6 months OR \\> 2% unwanted weight loss in combination with a BMI \\\u003C 20kg\u002Fm2 OR \\>2% unwanted weight loss in combination with sarcopenia\n* Cachexia staging score (CSS): 5-12\n\nExclusion Criteria:\n\n* Mental of psychological condition\n* Insufficient knowledge of the Dutch language\n* Muscle diseases affecting the spine and lower limbs\n* Bedridden\n\nNon-Cachectic cancer patients.\n\nInclusion criteria:\n\n* minimum age of 18 years old\n* No unwanted weight loss \\> 5% in the last 6 months OR \\> 2% unwanted weight loss in combination with a BMI \\\u003C 20kg\u002Fm2 OR \\>2% unwanted weight loss in combination with sarcopenia\n* Cachexia staging score (CSS): 0-2\n\nExclusion criteria:\n\n* Mental of psychological condition\n* Insufficient knowledge of the Dutch language\n* Muscle diseases affecting the spine and lower limbs\n* Bedridden\n\nHealthy controls.\n\nInclusion criteria:\n\n\\- minimum age of 18 years old\n\nExclusion criteria:\n\n* Mental of psychological condition\n* Insufficient knowledge of the Dutch language\n* Muscle diseases affecting the spine and lower limbs\n* Bedridden",{"count":347,"type":22},60,"2 Days","Until now, cancer is still associated with high morbidity and mortality, and is therefore a big issue for the public health. Colorectal cancer is the second leading cause of cancer death in developed countries. In advanced colorectal cancer, 60% of these patients develop cachexia. The presence of cachexia plays an important role in the high mortality rate of cancer. Cachexia is characterized by involuntary weight loss with loss of skeletal muscle with or without loss of fat mass.\n\nThe aim of this study is to determine the feasibility of taking muscle biopsies of cachectic colorectal cancer patients. Skeletal muscle characteristics will be compared between biopsies of the m. erector spinae and the m. vastus lateralis from cachectic colorectal cancer patients, non-cachectic colorectal cancer patients and healthy controls.\n\n10 cachectic, 25 non-cachectic, and 25 healthy controls will be recruited for this study. It is an observational study, so measurements will be taken at one time point. Interventions\u002Fmeasurements:\n\n* muscle biopsies\n* blood samples\n* 3D freehand ultrasound\n* Short physical performance battery test\n* handgrip strength\n* questionnaires (activity pattern, quality of life)",[351,352],"Colorectal Cancer","Cancer Cachexia",[354,355,356,357,358],"colorectal cancer","cachexia","skeletal muscle","skeletal muscle fibers","capillarization","2025-09-08",{"date":361,"type":37},"2025-09-09",{"date":363,"type":37},"2022-01-23",{"date":365,"type":22},"2025-09-10",{"name":43,"class":44},{"id":368,"slug":369,"hasResults":11,"nctId":370,"briefTitle":371,"officialTitle":372,"acronym":373,"eligibilityCriteria":374,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":375,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":377,"conditions":378,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":359,"lastUpdatePostDateStruct":380,"startDateStruct":381,"completionDateStruct":383,"leadSponsor":385,"locationsCount":45},"100550251","differences-in-extracellular-vesicles-from-adipose-tissue-of-individuals-with-obesity-100550251","NCT06444646","Differences in Extracellular Vesicles From Adipose Tissue of Individuals With Obesity.","The Adipose Tissue and Sex-specific Role of Adipose-derived Extracellular Vesicles in Obesity-related Skeletal Muscle Insulin Resistance.","EVO","Individuals with obesity - Inclusion Criteria:\n\n* Caucasian adults with obesity that have a body mass index (BMI) of at least 35 kg\u002Fm\\^2 and are scheduled for their first bariatric surgery.\n* Final male\u002Ffemale ratio of this study is 1:1\n* Minimal knowledge of Dutch to read and understand the informed consent.\n\nIndividuals with obesity - Exclusion Criteria:\n\n* Smoking and\u002For drug abuse\n* Cardiovascular diseases (including but not limited to implanted aids like a pacemaker or defibrillator)\n* Lung and\u002For kidney diseases\n* Brain and\u002For nerve diseases\n* Malignant diseases (e.g. cancer)\n\nIndividuals without obesity (lean) - inclusion criteria\n\n* Caucasian adults with obesity that have a body mass index (BMI) of between 18 and 24.9 kg\u002Fm\\^2 and are scheduled for abdominal surgery\n* Female only\n* Minimal knowledge of Dutch to read and understand the informed consent.\n\nIndividuals without obesity (lean) - exclusion criteria\n\n* Smoking and\u002For drug abuse\n* Cardiovascular diseases (including but not limited to implanted aids like a pacemaker or defibrillator)\n* Lung and\u002For kidney diseases\n* Brain and\u002For nerve diseases\n* Endocrine diseases like type 2 diabetes\n* Malignant diseases (e.g. cancer)",{"count":376,"type":22},150,"Our society is characterized by a strong increase in the prevalence of obesity, which often causes the development of cardiovascular and metabolic diseases such as type 2 diabetes. The way(s) obesity is responsible for these diseases, is still insufficiently understood. This study therefore examines the content of human fat tissue storage location- and cell type-specific extracellular vesicles (EVs) in lean and obese individuals, and the possible connection with sex, insulin sensitivity, and the blood-brain barrier.",[379],"Obesity",{"date":332,"type":37},{"date":382,"type":37},"2023-02-20",{"date":384,"type":22},"2026-09",{"name":43,"class":44},{"id":387,"slug":388,"hasResults":11,"nctId":389,"briefTitle":390,"officialTitle":391,"acronym":4,"eligibilityCriteria":392,"healthyVolunteers":11,"sex":17,"minAge":393,"maxAge":4,"enrollmentInfo":394,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":395,"conditions":396,"keywords":403,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":409,"lastUpdatePostDateStruct":410,"startDateStruct":412,"completionDateStruct":414,"leadSponsor":416,"locationsCount":45},"100602251","the-effects-of-a-dynamic-arm-support-in-daily-life-100602251","NCT07121075","The Effects of a Dynamic Arm Support in Daily Life","The Effects of a Dynamic Arm Support in Daily Life. A Mixed Methods Study Including the Different Components of the ICF","Inclusion Criteria:\n\n* Age: 16 and oler\n* Being able to understand and comprehend test instructions\n* Using a DAS from Focal Meditech (Balancer, Flowing, Dowing, Gowing 2 or Top Help)\n\nExclusion Criteria:\n\n\u002F","16 Years",{"count":320,"type":22},"The goal of this mixed method study is to learn about how a dynamic arm support device (DAS) helps people with everyday activities. The study focuses on people with neuro(-muscular) conditions, age 16 and older. The research questions that are formulated, are:\n\n* How does a person experience their daily activities, with and without a DAS?\n* What are the contextual (external and personal) factors that influence the use of a DAS?\n\nParticipants will take part in three testing sessions. In each session, they must complete a few questionnaires and participate in an interview. The first time, without DAS. In the second and third session, they will be using their DAS (resp. 3 to 4 weeks and 3 months). The data collection will be executed by phone, digital questionnaires and\u002For paper.",[397,398,399,400,401,402],"Neuromuscular Disease","Neuromuscular Disability","Assistive Technology","Activities of Daily Living","Occupational Therapy","Upper Limb",[404,405,406,407,408],"dynamic arm support","dynamic arm support device","ICF","daily life","outcome measures","2025-08-12",{"date":411,"type":37},"2025-08-13",{"date":413,"type":37},"2024-12-02",{"date":415,"type":22},"2026-08",{"name":43,"class":44},{"id":418,"slug":419,"hasResults":11,"nctId":420,"briefTitle":421,"officialTitle":422,"acronym":4,"eligibilityCriteria":423,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":424,"targetDuration":4,"studyType":90,"phases":426,"briefSummary":427,"conditions":428,"keywords":431,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":437,"lastUpdatePostDateStruct":438,"startDateStruct":440,"completionDateStruct":442,"leadSponsor":444,"locationsCount":45},"100599637","plasma-metabolomics-as-a-tool-to-distinguish-pet-positive-malignant-from-pet-positive-benign-nodules-100599637","NCT07087080","Plasma Metabolomics as a Tool to Distinguish PET-positive Malignant From PET-positive Benign Nodules","Combining PET-CT With a Glutamate-based Blood Test Improves Cancer Diagnosis in Solitary Pulmonary Nodules","Inclusion Criteria:\n\n* patients who undergo a PET-CT scan at ZOL for a lung nodule, who are willing to provide written informed consent\n\nExclusion Criteria:\n\n* no fasting starting 6h prior to blood sampling;\n* medication intake on the morning of blood sampling;\n* fasting blood glucose concentration is higher than 200 mg\u002FdL in the morning of blood sampling;\n* history of cancer during the past five years;\n* treatment for cancer during the past five years.",{"count":425,"type":22},350,[92],"Positron emission tomography-computed tomography (PET-CT) is an important technique in lung cancer staging, where almost no lung lesion goes undetected. However, PET-CT often fails to discriminate between malignant and non-malignant PET-positive solitary pulmonary nodules (SPNs) with a specificity of only 23%. 40-50% of those patients are advised to repeat their CT after three to six months to follow up on their lesions' progression, delaying a clear and correct cancer diagnosis and subsequent therapy. In more than 10% of the patients with an SPN on the PET-CT scan, an uncertain lung cancer diagnosis based on the PET-positive lesion leads to surgery that appears to be unnecessary.\n\nThis project aims to use the plasma glutamate concentration as a biomarker to complement PET-CT in the discrimination between malignant and non-malignant PET-positive SPNs. The investigators will validate a plasma glutamate determination by high- performance liquid chromatography (HPLC) since this test needs to be rapid, cheap, minimally invasive, and available in every hospital. In addition to the analysis of plasma glutamate, other plasma metabolites will be screened to check for other potential biomarkers to discriminate between malignant and non-malignant PET-positive SPNs. Together with the PET-CTs' basic parameters, a quick measurement of fasted plasma glutamate and potentially other biomarker levels right before undergoing a PET-CT scan will support a more rapid lung cancer diagnosis and treatment, resulting in less risk for disease progression. In conclusion, our approach will improve the accuracy of lung cancer diagnosis, and avoid unnecessary surgery.",[429,430],"Solitary Pulmonary Nodules","Lung Cancer",[432,433,434,435,436],"Pulmonary nodules","Lung cancer","Plasma metabolomics","1H-NMR","HPLC","2025-07-29",{"date":439,"type":37},"2025-07-31",{"date":441,"type":37},"2022-03-02",{"date":443,"type":22},"2027-11-01",{"name":43,"class":44},{"id":446,"slug":447,"hasResults":11,"nctId":448,"briefTitle":449,"officialTitle":450,"acronym":451,"eligibilityCriteria":452,"healthyVolunteers":16,"sex":206,"minAge":18,"maxAge":453,"enrollmentInfo":454,"targetDuration":4,"studyType":90,"phases":456,"briefSummary":457,"conditions":458,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":461,"lastUpdatePostDateStruct":462,"startDateStruct":464,"completionDateStruct":466,"leadSponsor":468,"locationsCount":45},"100507521","physical-activity-and-cardiovascular-profile-of-pre-conceptional-women-at-risk-for-ghd-100507521","NCT05888467","Physical Activity and Cardiovascular Profile of Pre-conceptional Women At Risk for GHD","The Impact of Physical Activity on the Cardiovascular Profile of Pre-conceptional Women At Risk for Developing Gestational Hypertensive Disorders in Subsequent Pregnancy.","SPORTY","Inclusion Criteria:\n\n* Women at risk for the development of GHD in subsequent pregnancy based on the presence of at least one of the following risk factors:\n\n  * high body mass index (BMI\\>30 kg\u002Fm²)\n  * a family history of PE (mother, sister)\n  * in the need of assisted reproduction techniques in a previous or subsequent pregnancy\n  * maternal comorbidities: prior PE, diabetes mellitus, chronic hypertension, chronic kidney disease or antiphospholipid syndrome\n* Non-pregnant (as confirmed by a negative pregnancy urine dipstick test)\n* Age ≥ 18 years\n* Being able to understand the Dutch language\n\nExclusion Criteria:\n\nParticipants eligible for this study must not meet any of the following criteria:\n\n* Pregnant at inclusion\n* Not being able to exercise according to physician's decision\n* Suffering from underlying diseases that can affect the CV profile such as oncological diseases coronary heart disease, aortic disease, peripheral arterial disease\n* Participating in another clinical study that may alter the results of this study","50 Years",{"count":455,"type":22},140,[92],"To compare the cardiovascular profile of pre-conceptional women at risk for developing Gestational Hypertensive Disorders in subsequent pregnancy before and after physical activity.",[459,460],"Gestational Hypertension","Cardiovascular Pregnancy Complication","2025-03-21",{"date":463,"type":37},"2025-03-26",{"date":465,"type":37},"2023-05-15",{"date":467,"type":22},"2025-12",{"name":43,"class":44},{"id":470,"slug":471,"hasResults":11,"nctId":472,"briefTitle":473,"officialTitle":474,"acronym":475,"eligibilityCriteria":476,"healthyVolunteers":11,"sex":17,"minAge":19,"maxAge":4,"enrollmentInfo":477,"targetDuration":4,"studyType":90,"phases":478,"briefSummary":479,"conditions":480,"keywords":482,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":489,"lastUpdatePostDateStruct":490,"startDateStruct":492,"completionDateStruct":494,"leadSponsor":496,"locationsCount":174},"100485627","adherence-by-music-to-exercise-in-dementia-group-therapy-100485627","NCT05603533","Adherence by Music to Exercise in Dementia: Group Therapy","The Effectiveness of a Music and Video-based Group Exercise Therapy in Older Adults With Moderate Dementia","AMUSED","Inclusion Criteria:\n\n* Men and women with moderate dementia (MMSE between 12 and 20)\n* Age 65 years or older\n* Resident in nursing home for at least 30 days\n* Able to stand (supported) for 10 seconds with supervision\n\nExclusion Criteria:\n\n* Inadequate functional hearing\n* Uncorrected visual problems\n* Rehabilitating from an orthopedic or neurologic insult\n* Known disability that significantly influences 6 month prognosis",{"count":127,"type":22},[92],"The aim of this study is to asses the effect of a music and video-based group exercise therapy on motivation, physical functioning, cognition and well-being in older adults with moderate dementia.",[481],"Dementia",[483,484,63,485,486,487,488],"Exercise therapy","Rehabilitation","Frailty","Treatment Adherence and Compliance","Cognition","Physical functioning","2024-10-07",{"date":491,"type":37},"2024-10-09",{"date":493,"type":37},"2023-01-09",{"date":495,"type":22},"2025-09",{"name":43,"class":44},{"id":498,"slug":499,"hasResults":11,"nctId":500,"briefTitle":501,"officialTitle":502,"acronym":4,"eligibilityCriteria":503,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":504,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":506,"conditions":507,"keywords":511,"overallStatus":249,"whyStopped":4,"lastUpdateSubmitDate":517,"lastUpdatePostDateStruct":518,"startDateStruct":520,"completionDateStruct":521,"leadSponsor":523,"locationsCount":45},"100564495","sensory-interaction-and-balance-control-during-standing-and-walking-in-healthy-young-and-older-adults-100564495","NCT06629922","Sensory Interaction and Balance Control During Standing and Walking in Healthy Young and Older Adults","Sensory Interaction and Balance Control During Standing and Walking Under Challenging Conditions in Healthy Young and Older Adults","Inclusion Criteria:\n\n* Young adults who: a) aged between 18 to 35 years old and, b) have never been diagnosed with somatosensory, visual, and vestibular deficits as reported by the participants, will be invited to participate. Community-dwelling older adults who: a) are 65 years old and over and, b) have not fallen in the last 12 months will also be invited to participate.\n\nExclusion Criteria:\n\n* having had serious lower extremity injuries or operations in the past year,\n* having any neurological (stroke, epilepsy, Parkinson's disease, etc.), sensory (i.e. peripheral neuropathy, diminished sense of pain, etc.) or motor disorder that can interfere with the results of the study\n* Diagnosed vascular, respiratory, cardiac, orthopedic, or other disorders that affect the subject's ability to exercise safely,\n* Medication affecting exercise tolerance. Additionally, based on the CAREN High-End Systems contraindications and risk factors the following exclusion criteria will be applied to the participants: a) a body weight higher than the 135 kg, b) an inability to properly adjust the harness to the respective body part due to pregnancy, colostomy bags, skin lesions that cannot be protected appropriately and any other reason that prevents a proper, pain-free adjustment of the harness.",{"count":505,"type":22},64,"This project is designed to: a) develop a new test called UHasselt Locomotor Sensory Integration Test (UHLSINT) which would allow us to evaluate sensory interaction process in locomotion assess whether Locomotor CTSIB and to investigate whether UHLSINT is a reliable test to evaluate sensory interaction in both young and older adults, b) evaluate the difference in sensory interaction and balance performance between standing and walking between both young and older adults, c) examine the changes in sensory interaction process under challenging conditions such as perturbations, dual-task, and when both are present between both young and older adults, d) examine the association between overall fall risk defined by the single-large perturbations and sensory interaction processes used during all the trials in both age groups.\n\nIn order to achieve these aims, 10 trials will be conducted:\n\nTrial 1- Single-Large Perturbation in Standing Trial 2- Single-Large Perturbation in Walking Trial 3- Instrumented CTSIB Trial 4- Locomotor CTSIB Trial 5- Instrumented CTSIB + Perturbations Trial 6- Locomotor CTSIB + Perturbations Trial 7- Instrumented CTSIB + Auditory Stroop Test Trial 8- Locomotor CTSIB + Auditory Stroop Test Trial 9- Instrumented CTSIB + Perturbations + Auditory Stroop Test Trial 10- Locomotor CTSIB + Perturbations + Auditory Stroop Test\n\nTwo different treadmill perturbations will be applied in addition to the Instrumented CTSIB and UHLSINT: a) slip perturbations, b) continuous perturbations. An auditory stroop task will be applied in relevant trials.\n\nAll of the trials will be performed in CAREN High-End Systems (Motek Medical BV, Amsterdam, The Netherlands) which is a motion capture system that is equipped with a treadmill mounted on a 6 degree of freedom motion base, a 360º dome-shaped virtual reality (VR) screen, and a marker-based movement analysis system.",[508,509,97,510],"Healthy","Young Adults","Elderly",[512,513,514,32,515,516],"sensory interaction","sensory reweighting","older adults","fall risk","fall","2024-10-04",{"date":519,"type":37},"2024-10-08",{"date":489,"type":22},{"date":522,"type":22},"2026-12-25",{"name":43,"class":44},{"id":525,"slug":526,"hasResults":11,"nctId":527,"briefTitle":528,"officialTitle":529,"acronym":530,"eligibilityCriteria":531,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":532,"targetDuration":4,"studyType":90,"phases":534,"briefSummary":536,"conditions":537,"keywords":540,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":546,"lastUpdatePostDateStruct":547,"startDateStruct":549,"completionDateStruct":551,"leadSponsor":553,"locationsCount":45},"100563145","phase-1-impact-of-the-boost-gait-program-on-gait-recovery-and-functional-mobility-after-stroke-100563145","NCT06612359","Impact of the BOOST GAIT Program on Gait Recovery and Functional Mobility After Stroke","Impact of the BOOST GAIT Program on Gait Recovery and Functional Mobility After Stroke - a Pilot Study Impact Van Het BOOST GAIT Programma Op Het Herstel Van Het Gangbeeld En Functionele Mobiliteit Na Een Beroerte - Een Pilootstudie","BOOST GAIT","Inclusion Criteria:\n\n* A first-ever unilateral stroke, infarction or bleeding\n* Undergoing inpatient rehabilitation in the Jessa hospital, Herk-de-Stad\n* Less than 3 months after stroke onset at the moment of inclusion\n* 18 years of older\n* Berg Balance Scale score 24 or higher (out of 56) at moment of inclusion\n* Timed Up-and-Go score 14 s or higher at moment of inclusion\n* Functional Ambulation Category 3 or higher at moment of inclusion\n* Understanding the goals and procedures of this study and giving informed consent\n\nExclusion Criteria:\n\n* Significant cognitive and\u002For speech impairments that markedly affect the comprehension and execution of instructions",{"count":533,"type":22},12,[535],"PHASE1","The overarching goal is to determine if the BOOST GAIT program can improve functional mobility in patients with stroke who are undergoing inpatient rehabilitation and have some walking function, through the application of augmented therapeutic exercises designed to achieve a normative gait pattern. The evaluation will be conducted using a combination of clinical scales and objective motion sensors that map walking quality and performance during activities of daily living, such as rising from a chair and standing.\n\nIt is acknowledged that this single-group pilot study, which aims to include 12 participants, is insufficiently powered to address the primary objective. A larger parallel-design study is required to definitively address this issue. To help design a larger study, the current objectives are: first, to have realistic expectations regarding recruitment and dropout rates; second, to identify potential barriers to therapy adherence and data collection that may impede the success of a larger study; third, assess the test-retest reliability of sensor-based motion capture of movement quality during walking and related tasks in hemiparetic stroke patients. For the latter objective, the sensor measurements at the end of the intervention will be repeated on two consecutive days.\n\nIn addition to their usual care, participants will undergo additional therapy over a four-week period, with sessions occurring five times per week for one hour as part of the BOOST GAIT program. The BOOST GAIT sessions will be conducted as group-based therapy with four patients and two physiotherapists present to oversee the performance of mobility-specific exercises, including sit-to-stand transfers, standing and stepping, and eventually walking. The rationale for this approach is that the combined effects of augmenting the amount of therapeutic exercises and specifically targeting motor control of the paretic leg will facilitate symmetry during tasks, which in turn will have carry-over effects on safe performance of walking and other mobility tasks.",[538,539],"Stroke with Hemiparesis","Stroke",[541,542,543,544,539,545,300],"Recovery","Gait","Physical exercise","Pilot study","Hemiparesis","2024-09-21",{"date":548,"type":37},"2024-09-25",{"date":550,"type":37},"2024-09-02",{"date":552,"type":22},"2024-12-31",{"name":43,"class":44},{"id":555,"slug":556,"hasResults":11,"nctId":557,"briefTitle":558,"officialTitle":558,"acronym":559,"eligibilityCriteria":560,"healthyVolunteers":16,"sex":17,"minAge":561,"maxAge":562,"enrollmentInfo":563,"targetDuration":4,"studyType":90,"phases":565,"briefSummary":566,"conditions":567,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":570,"lastUpdatePostDateStruct":571,"startDateStruct":573,"completionDateStruct":575,"leadSponsor":577,"locationsCount":45},"100368245","hyperventilation-in-patients-with-chronic-low-back-pain-100368245","NCT04074798","Hyperventilation in Patients With Chronic Low Back Pain","HELBP","Inclusion Criteria Patients:\n\n* Chronic primary low back pain (\\>12 weeks) as diagnosed by a medical doctor\n\nInclusion Criteria Healthy controls:\n\n* No low back pain\n\nExclusion Criteria:\n\n* Insufficient understanding of Dutch language\n* Previous spinal surgery\n* Chronic Obstructive Lung Disease, Interstitial Lung Disease, pulmonary vascular disease, asthma except for exertional asthma\n* Acute cardiovascular or gastrointestinal disorders\n* Neuromuscular disease interfering with normal lower limb or trunk functioning\n* Acute pain or secondary chronic pain\n* Pregnant and lactating women\n* Major psychiatric conditions\n* Acute lower limb problems\n* Vestibular disorders","20 Years","60 Years",{"count":564,"type":22},90,[92],"Low back pain (LBP) is the leading cause of disability worldwide. Impaired postural control is a key factor in the development and maintenance of LBP. Moreover, the prevalence of LBP is associated with impairments in diaphragm function, symptoms of dyspnea, and dysfunctional breathing. However, the association between LBP (and more specifically postural control) and hyperventilation remains unknown. The main objective of this project is to investigate whether the presence of recurrent non-specific LBP is related to the presence of hyperventilation, when classified either objectively by decreased carbon dioxide values (demonstrating hypocapnia) or by symptoms while showing normal carbon dioxide values. Moreover, the investigators will explore whether psychosocial factors play a role in this relation. Subsequently, the investigators will examine whether hyperventilation in LBP patients is related to impaired postural control, and more specifically to a decreased postural contribution of the diaphragm.",[568,569],"Low Back Pain, Recurrent","Hyperventilation Syndrome","2024-08-21",{"date":572,"type":37},"2024-08-22",{"date":574,"type":37},"2020-03-01",{"date":576,"type":22},"2025-07",{"name":43,"class":44},{"id":579,"slug":580,"hasResults":11,"nctId":581,"briefTitle":582,"officialTitle":582,"acronym":583,"eligibilityCriteria":584,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":585,"targetDuration":4,"studyType":90,"phases":587,"briefSummary":588,"conditions":589,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":593,"lastUpdatePostDateStruct":594,"startDateStruct":596,"completionDateStruct":598,"leadSponsor":600,"locationsCount":174},"100553825","technology-supported-high-intensity-training-in-chronic-low-back-pain-the-techno-hit-trial-100553825","NCT06491121","Technology Supported High Intensity Training in Chronic Low Back Pain: the Techno-HIT Trial","TECHNO-HIT","Inclusion Criteria:\n\n* speak Dutch\n* be 18 to 65 years old\n* have nonspecific CLBP defined as chronic primary musculoskeletal pain (ICD-11: MG30.011) in the low back persisting for at least 12 weeks12, whereby fluctuations in pain can be present and pain can be alternated by remission phases. Furthermore, regarding the specification of 'severity', only participants with a profile consisting of a score of \\>20% on the Modified Oswestry disability Index (i.e. 'moderate disability') will be included.\n* have and make use of a working iOS\u002FAndroid smartphone\n\nExclusion Criteria:\n\n* when they have had spinal fusion surgery\n* when they have a musculoskeletal and\u002For chronic disorder aside from CLBP that could affect the correct execution of the therapy program or evaluation of the outcomes\n* when they have severe comorbidities (e.g., paresis or sensory disturbances by neurological causes, diabetes mellitus, rheumatoid arthritis)\n* when they are pregnant\n* when they have ongoing compensation claims\n* when they are not able to attend regular therapy appointments",{"count":586,"type":22},168,[92],"Chronic low back pain (CLBP) is one of the most common chronic musculoskeletal disorder worldwide and is responsible for the highest levels of disability of all diseases. All state-of-the-art guidelines recommend implementing exercise therapy (ET) in CLBP management. Researchers have shown that a novel ET modality, namely high intensity training (HIT), can be valuable. A clinical evaluation study in a larger spectrum of persons with CLBP in a rehabilitation centre setting is essential. Thereby, technology might support HIT.\n\nThe primary goal of this clinical trial is to evaluate the short- and long-term effectiveness of a time contingent individualized High intensity training (HIT) protocol on disability compared to moderate intensity training (MIT) in persons with severely disabling chronic low back pain (CLBP). Secondary goals entail 1) evaluating short- and long-term effectiveness of HIT on psychosocial correlates, central pain processing, and broad physical fitness, 2) investigating additional effects of (prolonged) HIT at home, 3) investigating added value of technology through a mobile (smartphone) and dashboard (computer) application that offers support during home training, 4) evaluating cost-effectiveness of (technology supported) HIT compared to MIT. The main research question\\[s\\] (RQ) it aims to answer are:\n\n* RQ1: To what extent is HIT effective on the short- and long term to improve disability in persons with severely disabling CLBP compared to MIT as used in usual care?\n* RQ2a: To what extent does HIT have a short- and\u002For long-term effect on central pain processing and psychosocial correlates in persons with severely disabling CLBP?\n* RQ2b:To what extent does HIT have a short- and\u002For long-term effect on outcomes related to broad physical fitness in persons with severely disabling CLBP?\n* RQ3a: To what extent does prolonged (technology-supported) HIT at home provide additional training effects in persons with severely disabling CLBP?\n* RQ3b:To what extent does a mobile application that offers support for HIT at home provide added value for treatment outcomes of persons with severely disabling CLBP?\n* RQ3c:To what extent is the techno-HIT application usable and qualitative (assessed by SUS and uMARS) as a therapeutic support mechanism, as evaluated by persons with severely disabling CLBP?\n* RQ4: To what extent is HIT or HIT supported by a mobile application cost effective compared to MIT for patients with severely disabling CLBP?",[590,591,592],"Chronic Low-back Pain","Exercise Therapy","Telerehabilitation","2024-07-03",{"date":595,"type":37},"2024-07-08",{"date":597,"type":37},"2024-05-27",{"date":599,"type":22},"2029-03",{"name":43,"class":44},{"id":602,"slug":603,"hasResults":11,"nctId":604,"briefTitle":605,"officialTitle":605,"acronym":606,"eligibilityCriteria":607,"healthyVolunteers":16,"sex":206,"minAge":18,"maxAge":453,"enrollmentInfo":608,"targetDuration":4,"studyType":90,"phases":610,"briefSummary":611,"conditions":612,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":615,"lastUpdatePostDateStruct":616,"startDateStruct":618,"completionDateStruct":620,"leadSponsor":622,"locationsCount":623},"100324843","limpron-limburg-pre-eclampsia-investigation-100324843","NCT03509272","LimPrOn: Limburg Pre-eclampsia Investigation","LimPrOn","Inclusion Criteria:\n\n* \\> 10 weeks of pregnancy, primipara and multipara\n\nExclusion Criteria:\n\n* \\\u003C 10 weeks of pregnancy and congenital malformations of the fetus",{"count":609,"type":22},2000,[92],"Background:\n\nMultiple adaptations at the cardiovascular system occurs during pregnancy. In the pregnancy condition pre-eclampsia (PE), this adaptations are abnormal. Five to eight percent of all pregnant women worldwide will develop PE.\n\nPE is a pregnancy condition which is characterized with a high blood pressure (\\>140\u002F90 mm Hg) and the occurrence of proteinuria (\\>3g\u002Fdl\u002F24h) after 20 weeks of gestation. When untreated, this condition can have severe complications for both mother and child. It's important to monitor women with a high risk for developing PE for an early detection and treatment of this condition.\n\nFor this reason, a multicenter study is set up with the following applications:\n\n1. NICCOMO and Maternal Venous Doppler Echography: impedance cardiograph and an echography of the heart and veins.\n2. Maltron: bio-electronic impedance analyze\n3. Remote monitoring of the high risk patients to become a more intensive follow-up\n\nNumber of inclusions: 2000 pregnant women from the prenatal consultations of eight different hospitals:",[613,614],"Pregnancy","Pre-eclampsia","2024-04-08",{"date":617,"type":37},"2024-04-09",{"date":619,"type":4},"2016-05",{"date":621,"type":22},"2030-12",{"name":43,"class":44},8,{"id":625,"slug":626,"hasResults":11,"nctId":627,"briefTitle":628,"officialTitle":629,"acronym":630,"eligibilityCriteria":631,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":562,"enrollmentInfo":632,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":633,"conditions":634,"keywords":636,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":643,"lastUpdatePostDateStruct":644,"startDateStruct":646,"completionDateStruct":648,"leadSponsor":650,"locationsCount":284},"100504658","the-forgotten-role-of-back-muscle-characteristics-to-tailor-exercise-therapy-for-recurrent-non-specific-low-back-pain-100504658","NCT05851196","The Forgotten Role of Back Muscle Characteristics to Tailor Exercise Therapy for Recurrent Non-specific Low Back Pain","Back to Back: the Forgotten Role of Back Muscle Characteristics to Tailor Exercise Therapy for Recurrent Non-specific Low Back Pain","Back-to-Back","Inclusion Criteria:\n\nPatients with non-specific low back pain:\n\n* Aged 18-60 years\n* Non-specific low back pain without radicular leg pain\n* Mechanical low back pain with episodes of \\\u003C4 on the numerical pain rating scale and episodes of \\>6 on the numerical pain rating scale\n* Non-specific low back pain for three months or more\n* Score of 20% or more on the Modified Low Back Pain Disability Questionnaire\n* Informed consent to participate\n\nHealthy controls:\n\n* Aged 18-60 years\n* No history of low back pain needing medical treatment or resulting in a limited activity level\n* No low back pain in the previous six months\n* Informed consent to participate\n\nExclusion Criteria:\n\n* Pregnancy\n* Previous trauma or surgery to the spine, pelvis or lower limbs\n* Structural spinal deformity (e.g., scoliosis)\n* Neurological, neuromuscular, respiratory or systemic disease\n* Central sensitization: score of 50\u002F100 or more on the Central Sensitization Inventory\n* Specific vestibular or balance problems\n* Acute lower limb or neck problems\n* Body mass index of 30 kg\u002Fm² or more",{"count":156,"type":22},"Patients with non-specific low back pain will be compared to healthy, age- and sex-matched controls to determine the most discriminating back muscle characteristics and to delineate possible phenotypes of patients with non-specific low back pain showing impaired proprioceptive postural control. Additionally, the group of patients with non-specific low back pain will receive a 16-week, high-load proprioceptive training program. The effects of this training program on the different back muscle characteristics and proprioceptive postural control will be evaluated.",[214,635],"Back Pain Lower Back Chronic",[637,638,639,640,641,642],"Proprioceptive postural control","Muscle volume","Muscle activation","Muscle oxygenation","Muscle fiber type composition","Proprioceptive training","2024-02-26",{"date":645,"type":37},"2024-02-28",{"date":647,"type":37},"2024-01-15",{"date":649,"type":22},"2027-12-31",{"name":43,"class":44},""]